BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID of Ligand PubChem SID of Ligand ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence PDB ID(s) of Target Chain UniProt (SwissProt) Recommended Name of Target Chain UniProt (SwissProt) Entry Name of Target Chain UniProt (SwissProt) Primary ID of Target Chain UniProt (SwissProt) Secondary ID(s) of Target Chain UniProt (SwissProt) Alternative ID(s) of Target Chain UniProt (TrEMBL) Submitted Name of Target Chain UniProt (TrEMBL) Entry Name of Target Chain UniProt (TrEMBL) Primary ID of Target Chain UniProt (TrEMBL) Secondary ID(s) of Target Chain UniProt (TrEMBL) Alternative ID(s) of Target Chain 470769 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(Cl)c2)n(CC2CCCCC2)c1=O InChI=1S/C25H35ClN4O5/c1-16(2)35-20-12-11-18(13-19(20)26)27-22-28-23(32)30(15-25(3,4)21(31)34-5)24(33)29(22)14-17-9-7-6-8-10-17/h11-13,16-17H,6-10,14-15H2,1-5H3,(H,27,28,32) DEKOKCCTTJDCJS-UHFFFAOYSA-N 183373 US9150546, I-547::US9688643, I-547::US9718790, I-0556 P2X purinoceptor 3 Homo sapiens 11 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183373 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183373&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578842 313634773 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470770 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(Cl)c2)n(CC2CCCCC2)c1=O 183374 US9150546, I-548::US9688643, I-548::US9718790, I-0557 P2X purinoceptor 3 Homo sapiens 12 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183374 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183374&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578956 313634774 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470771 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(Cl)c2)n(CC2CCCCCC2)c1=O InChI=1S/C26H37ClN4O5/c1-17(2)36-21-13-12-19(14-20(21)27)28-23-29-24(33)31(16-26(3,4)22(32)35-5)25(34)30(23)15-18-10-8-6-7-9-11-18/h12-14,17-18H,6-11,15-16H2,1-5H3,(H,28,29,33) NEKLZKIZXQWIFI-UHFFFAOYSA-N 183375 US9150546, I-549::US9688643, I-549::US9718790, I-0558 P2X purinoceptor 3 Homo sapiens 19 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183375 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183375&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578662 313634775 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470772 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(Cl)c2)n(CC2CCCC2)c1=O InChI=1S/C24H33ClN4O5/c1-15(2)34-19-11-10-17(12-18(19)25)26-21-27-22(31)29(14-24(3,4)20(30)33-5)23(32)28(21)13-16-8-6-7-9-16/h10-12,15-16H,6-9,13-14H2,1-5H3,(H,26,27,31) HESZPANWMDSMDF-UHFFFAOYSA-N 183376 US9150546, I-550::US9688643, I-550::US9718790, I-0559 P2X purinoceptor 3 Homo sapiens 33 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183376 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183376&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578533 313634776 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470773 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n1CC1CCCCC1 InChI=1S/C24H33ClN4O5/c1-15(2)34-19-11-10-17(12-18(19)25)26-21-27-22(32)29(14-24(3,4)20(30)31)23(33)28(21)13-16-8-6-5-7-9-16/h10-12,15-16H,5-9,13-14H2,1-4H3,(H,30,31)(H,26,27,32) NMNCTROXPGYIOQ-UHFFFAOYSA-N 183377 US9150546, I-551::US9688643, I-551::US9718790, I-0560 P2X purinoceptor 3 Homo sapiens 34 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183377 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183377&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578406 313634777 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470774 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1CC1CCCCC1 183378 US9150546, I-552::US9688643, I-552::US9718790, I-0561 P2X purinoceptor 3 Homo sapiens 23 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183378 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183378&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578395 313634778 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470775 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n1CC1CCCCCC1 InChI=1S/C25H35ClN4O5/c1-16(2)35-20-12-11-18(13-19(20)26)27-22-28-23(33)30(15-25(3,4)21(31)32)24(34)29(22)14-17-9-7-5-6-8-10-17/h11-13,16-17H,5-10,14-15H2,1-4H3,(H,31,32)(H,27,28,33) ZVPWBFOPYYQMCZ-UHFFFAOYSA-N 183379 US9150546, I-553::US9688643, I-553::US9718790, I-0562 P2X purinoceptor 3 Homo sapiens 34 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183379 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183379&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578707 313634779 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470776 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n1CC1CCCC1 InChI=1S/C23H31ClN4O5/c1-14(2)33-18-10-9-16(11-17(18)24)25-20-26-21(31)28(13-23(3,4)19(29)30)22(32)27(20)12-15-7-5-6-8-15/h9-11,14-15H,5-8,12-13H2,1-4H3,(H,29,30)(H,25,26,31) KHYUIQKXCLVOAV-UHFFFAOYSA-N 183380 US9150546, I-554::US9688643, I-554::US9718790, I-0563 P2X purinoceptor 3 Homo sapiens 139 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183380 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183380&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578656 313634780 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470777 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(C)c2)n(CC2CCCCC2)c1=O 183381 US9150546, I-555::US9688643, I-555::US9718790, I-0564 P2X purinoceptor 3 Homo sapiens 13 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183381 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183381&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578401 313634781 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470778 COC(=O)C[C@@H](C)n1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(Cl)c2)n(Cc2ccc(Cl)cc2)c1=O 183382 US9150546, I-556::US9688643, I-556::US9718790, I-0565 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183382 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183382&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578716 313634782 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470779 COC(=O)C[C@@H](C)n1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O 183383 US9150546, I-557::US9688643, I-557::US9718790, I-0566 P2X purinoceptor 3 Homo sapiens 19 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183383 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183383&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578452 313634783 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470780 COC(=O)[C@H](C)Cn1c(=O)[nH]\c(=N/c2ccc3oc(C)cc3c2)n(Cc2ccc(Cl)cc2)c1=O 183384 US9150546, I-558::US9688643, I-558::US9718790, I-0567 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183384 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183384&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578519 313634784 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470781 CC(C)Oc1ccc(cc1C)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1CC1CCCCC1 183385 US9150546, I-559::US9688643, I-559::US9718790, I-0568 P2X purinoceptor 3 Homo sapiens 97 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183385 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183385&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578595 313634785 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470782 COC(=O)C[C@@H](C)n1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O 183386 US9150546, I-560::US9688643, I-560::US9718790, I-0569 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183386 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183386&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578772 313634786 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470783 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n([C@H](C)CC(O)=O)c(=O)n1Cc1ccc(Cl)cc1 183387 US9150546, I-561::US9688643, I-561::US9718790, I-0570 P2X purinoceptor 3 Homo sapiens 8.00 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183387 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183387&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578547 313634787 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470784 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n([C@H](C)CC(O)=O)c(=O)n1Cc1ccc(Cl)cc1 183388 US9150546, I-562::US9688643, I-562::US9718790, I-0571 P2X purinoceptor 3 Homo sapiens 27 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183388 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183388&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578745 313634788 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470785 CC(C)Oc1ccc(cc1C)\N=c1/[nH]c(=O)n([C@H](C)CC(O)=O)c(=O)n1Cc1ccc(Cl)cc1 183389 US9150546, I-563::US9688643, I-563::US9718790, I-0572 P2X purinoceptor 3 Homo sapiens 40 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183389 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183389&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578867 313634789 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470786 C[C@H](Cn1c(=O)[nH]\c(=N/c2ccc3oc(C)cc3c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 183390 US9150546, I-564::US9688643, I-564::US9718790, I-0573 P2X purinoceptor 3 Homo sapiens 48 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183390 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183390&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578819 313634790 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470787 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(nc(=O)n1Cc1ccc(Cl)cc1)N1CCCC1=O InChI=1S/C23H23Cl2N5O3/c1-14(2)33-19-10-9-17(12-18(19)25)26-21-27-22(29-11-3-4-20(29)31)28-23(32)30(21)13-15-5-7-16(24)8-6-15/h5-10,12,14H,3-4,11,13H2,1-2H3,(H,26,27,28,32) AGOKXKCSCRKDNJ-UHFFFAOYSA-N 183391 US9150546, II-012::US9688643, II-012::US9718790, I-0576 P2X purinoceptor 3 Homo sapiens 568 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183391 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183391&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 119099073 313634791 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470788 CCN(CC)c1nc(=O)n(Cc2ccc(Cl)cc2)\c(=N\c2ccc(OC(C)C)c(Cl)c2)[nH]1 InChI=1S/C23H27Cl2N5O2/c1-5-29(6-2)21-27-22(26-18-11-12-20(19(25)13-18)32-15(3)4)30(23(31)28-21)14-16-7-9-17(24)10-8-16/h7-13,15H,5-6,14H2,1-4H3,(H,26,27,28,31) QIYDVXQPYHCHGL-UHFFFAOYSA-N 183392 US9150546, II-013::US9688643, II-013::US9718790, I-0577 P2X purinoceptor 3 Homo sapiens 430 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183392 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183392&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 119099074 313634792 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470789 CCOc1nc(=O)n(Cc2ccc(Cl)cc2)\c(=N\c2ccc(OC(C)C)c(Cl)c2)[nH]1 InChI=1S/C21H22Cl2N4O3/c1-4-29-20-25-19(24-16-9-10-18(17(23)11-16)30-13(2)3)27(21(28)26-20)12-14-5-7-15(22)8-6-14/h5-11,13H,4,12H2,1-3H3,(H,24,25,26,28) INJXKGYCADCMNE-UHFFFAOYSA-N 183393 US9150546, II-014::US9688643, II-014::US9718790, I-0578 P2X purinoceptor 3 Homo sapiens 254 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183393 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183393&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 119099075 313634793 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470790 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(CCC(O)=O)nc(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C22H22Cl2N4O4/c1-13(2)32-18-8-7-16(11-17(18)24)25-21-26-19(9-10-20(29)30)27-22(31)28(21)12-14-3-5-15(23)6-4-14/h3-8,11,13H,9-10,12H2,1-2H3,(H,29,30)(H,25,26,27,31) HSAJOPASXWABBQ-UHFFFAOYSA-N 183394 US9150546, II-015::US9688643, II-015::US9718790, I-0579 P2X purinoceptor 3 Homo sapiens 614 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183394 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183394&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 119099076 313634794 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470558 OCCn1c(=O)nc(Nc2ccc(OC3CCCC3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H25ClN4O4/c24-17-7-5-16(6-8-17)15-28-21(26-22(30)27(13-14-29)23(28)31)25-18-9-11-20(12-10-18)32-19-3-1-2-4-19/h5-12,19,29H,1-4,13-15H2,(H,25,26,30) QCYBCGKXTXODTF-UHFFFAOYSA-N 183162 US9150546, I-322::US9688643, I-322::US9718790, I-0322 P2X purinoceptor 3 Homo sapiens 112 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183162 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183162&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821323 313634562 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470559 CC(C)COc1ccc(Nc2nc(=O)n(CCO)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C22H24ClFN4O4/c1-14(2)13-32-19-8-7-17(11-18(19)24)25-20-26-21(30)27(9-10-29)22(31)28(20)12-15-3-5-16(23)6-4-15/h3-8,11,14,29H,9-10,12-13H2,1-2H3,(H,25,26,30) DCGRXCWZDNUUBX-UHFFFAOYSA-N 183163 US9150546, I-323::US9688643, I-323::US9718790, I-0323 P2X purinoceptor 3 Homo sapiens 148 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183163 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183163&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821442 313634563 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470560 OCCn1c(=O)nc(Nc2ccc(OC3CCOCC3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H25ClN4O5/c24-17-3-1-16(2-4-17)15-28-21(26-22(30)27(11-12-29)23(28)31)25-18-5-7-19(8-6-18)33-20-9-13-32-14-10-20/h1-8,20,29H,9-15H2,(H,25,26,30) KUNJUWMHHWZXFE-UHFFFAOYSA-N 183164 US9150546, I-324::US9688643, I-324::US9718790, I-0324 P2X purinoceptor 3 Homo sapiens 309 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183164 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183164&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821216 313634564 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470561 CC(C)Oc1ccc(Nc2nc(=O)n(CCO)c(=O)[nH]2)cc1F InChI=1S/C14H17FN4O4/c1-8(2)23-11-4-3-9(7-10(11)15)16-12-17-13(21)19(5-6-20)14(22)18-12/h3-4,7-8,20H,5-6H2,1-2H3,(H2,16,17,18,21,22) SIRUOEAXMZXYMV-UHFFFAOYSA-N 183165 US9150546, I-325::US9688643, I-325::US9718790, I-0325 P2X purinoceptor 3 Homo sapiens 665 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183165 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183165&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821351 313634565 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470562 CC(C)Oc1ccc(Nc2nc(=O)n(CCCNC(C)=O)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C24H27ClFN5O4/c1-15(2)35-21-10-9-19(13-20(21)26)28-22-29-23(33)30(12-4-11-27-16(3)32)24(34)31(22)14-17-5-7-18(25)8-6-17/h5-10,13,15H,4,11-12,14H2,1-3H3,(H,27,32)(H,28,29,33) IFZZAWGUWRJMDO-UHFFFAOYSA-N 183166 US9150546, I-326::US9688643, I-326::US9718790, I-0326 P2X purinoceptor 3 Homo sapiens 11 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183166 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183166&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821044 313634566 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470563 CC(C)Cc1ccc(Nc2nc(=O)n(CCO)c(=O)n2Cc2ccc(Cl)cc2)cc1 InChI=1S/C22H25ClN4O3/c1-15(2)13-16-5-9-19(10-6-16)24-20-25-21(29)26(11-12-28)22(30)27(20)14-17-3-7-18(23)8-4-17/h3-10,15,28H,11-14H2,1-2H3,(H,24,25,29) JJEVCTBXYVKJGJ-UHFFFAOYSA-N 183167 US9150546, I-328::US9688643, I-328::US9718790, I-0328 P2X purinoceptor 3 Homo sapiens 124 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183167 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183167&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821364 313634567 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470564 OCCn1c(=O)nc(Nc2ccc(OC(F)F)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C19H17ClF2N4O4/c20-13-3-1-12(2-4-13)11-26-17(24-18(28)25(9-10-27)19(26)29)23-14-5-7-15(8-6-14)30-16(21)22/h1-8,16,27H,9-11H2,(H,23,24,28) RKXQIFCQXRKXAA-UHFFFAOYSA-N 183168 US9150546, I-329::US9688643, I-329::US9718790, I-0329 P2X purinoceptor 3 Homo sapiens 266 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183168 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183168&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821162 313634568 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470565 OCCn1c(=O)nc(Nc2ccc(OCC#N)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C20H18ClN5O4/c21-15-3-1-14(2-4-15)13-26-18(24-19(28)25(10-11-27)20(26)29)23-16-5-7-17(8-6-16)30-12-9-22/h1-8,27H,10-13H2,(H,23,24,28) DAHFGHKKJUUEMZ-UHFFFAOYSA-N 183169 US9150546, I-330::US9688643, I-330::US9718790, I-0330 P2X purinoceptor 3 Homo sapiens 594 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183169 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183169&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821450 313634569 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470566 CC(C)Oc1ccc(Nc2nc(=O)n(CC(C)(C)CN)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C24H29ClFN5O3/c1-15(2)34-20-10-9-18(11-19(20)26)28-21-29-22(32)31(14-24(3,4)13-27)23(33)30(21)12-16-5-7-17(25)8-6-16/h5-11,15H,12-14,27H2,1-4H3,(H,28,29,32) KNTGWOHWZKIFHC-UHFFFAOYSA-N 183170 US9150546, I-331::US9688643, I-331::US9718790, I-0331 P2X purinoceptor 3 Homo sapiens 66 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183170 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183170&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821383 313634570 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470567 CC(C)Oc1ccc(Nc2nc(=O)n(CC(C)(C)CO)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C24H28ClFN4O4/c1-15(2)34-20-10-9-18(11-19(20)26)27-21-28-22(32)30(13-24(3,4)14-31)23(33)29(21)12-16-5-7-17(25)8-6-16/h5-11,15,31H,12-14H2,1-4H3,(H,27,28,32) HGRPNRICIGWDCD-UHFFFAOYSA-N 183171 US9150546, I-332::US9688643, I-332::US9718790, I-0332 P2X purinoceptor 3 Homo sapiens 8.00 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183171 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183171&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821434 313634571 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470568 CC(C)Oc1ccc(Nc2nc(=O)n(CCO)c(=O)n2Cc2ccc(F)cc2)cc1F InChI=1S/C21H22F2N4O4/c1-13(2)31-18-8-7-16(11-17(18)23)24-19-25-20(29)26(9-10-28)21(30)27(19)12-14-3-5-15(22)6-4-14/h3-8,11,13,28H,9-10,12H2,1-2H3,(H,24,25,29) UKLFEXAABNFJMM-UHFFFAOYSA-N 183172 US9150546, I-333::US9688643, I-333::US9718790, I-0333 P2X purinoceptor 3 Homo sapiens 192 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183172 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183172&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821111 313634572 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470569 OCCn1c(=O)nc(Nc2ccc(Oc3ccccc3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H21ClN4O4/c25-18-8-6-17(7-9-18)16-29-22(27-23(31)28(14-15-30)24(29)32)26-19-10-12-21(13-11-19)33-20-4-2-1-3-5-20/h1-13,30H,14-16H2,(H,26,27,31) KLZCINWURKWDQT-UHFFFAOYSA-N 183173 US9150546, I-334::US9688643, I-334::US9718790, I-0334 P2X purinoceptor 3 Homo sapiens 99 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183173 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183173&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76820945 313634573 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470570 CC(C)Oc1ccc(Nc2nc(=O)n(CC3(CO)CC3)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C24H26ClFN4O4/c1-15(2)34-20-8-7-18(11-19(20)26)27-21-28-22(32)30(13-24(14-31)9-10-24)23(33)29(21)12-16-3-5-17(25)6-4-16/h3-8,11,15,31H,9-10,12-14H2,1-2H3,(H,27,28,32) NHPKSMZBRJQQSF-UHFFFAOYSA-N 183174 US9150546, I-335::US9688643, I-335::US9718790, I-0335 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183174 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183174&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821197 313634574 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470571 COC(=O)Cn1c(=O)nc(Nc2ccc(OC(C)C)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C22H22ClFN4O5/c1-13(2)33-18-9-8-16(10-17(18)24)25-20-26-21(30)28(12-19(29)32-3)22(31)27(20)11-14-4-6-15(23)7-5-14/h4-10,13H,11-12H2,1-3H3,(H,25,26,30) FLNMUXWIGQAANO-UHFFFAOYSA-N 183175 US9150546, I-338::US9688643, I-338::US9718790, I-0338 P2X purinoceptor 3 Homo sapiens 53 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183175 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183175&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76820973 313634575 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470572 CC(C)Oc1ccc(Nc2nc(=O)n(CCO)c(=O)n2Cc2ccc(F)c(F)c2)cc1F InChI=1S/C21H21F3N4O4/c1-12(2)32-18-6-4-14(10-17(18)24)25-19-26-20(30)27(7-8-29)21(31)28(19)11-13-3-5-15(22)16(23)9-13/h3-6,9-10,12,29H,7-8,11H2,1-2H3,(H,25,26,30) CUQQYEWTZONCKB-UHFFFAOYSA-N 183176 US9150546, I-339::US9688643, I-339::US9718790, I-0339 P2X purinoceptor 3 Homo sapiens 775 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183176 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183176&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821332 313634576 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470573 CC(C)Oc1ccc(Nc2nc(=O)n(CCO)c(=O)n2Cc2ccc(F)cc2F)cc1F InChI=1S/C21H21F3N4O4/c1-12(2)32-18-6-5-15(10-17(18)24)25-19-26-20(30)27(7-8-29)21(31)28(19)11-13-3-4-14(22)9-16(13)23/h3-6,9-10,12,29H,7-8,11H2,1-2H3,(H,25,26,30) RTZOYNJXYRFCMD-UHFFFAOYSA-N 183177 US9150546, I-340::US9688643, I-340::US9718790, I-0340 P2X purinoceptor 3 Homo sapiens 336 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183177 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183177&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821109 313634577 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470574 CC(C)Oc1ccc(Nc2nc(=O)n(CCO)c(=O)n2Cc2ccc(Cl)c(F)c2)cc1F InChI=1S/C21H21ClF2N4O4/c1-12(2)32-18-6-4-14(10-17(18)24)25-19-26-20(30)27(7-8-29)21(31)28(19)11-13-3-5-15(22)16(23)9-13/h3-6,9-10,12,29H,7-8,11H2,1-2H3,(H,25,26,30) QSZIEXCHKXBPKQ-UHFFFAOYSA-N 183178 US9150546, I-341::US9688643, I-341::US9718790, I-0341 P2X purinoceptor 3 Homo sapiens 149 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183178 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183178&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821011 313634578 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470575 CC(C)Oc1ccc(Nc2nc(=O)n(CCCOC3CCCCO3)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C27H32ClFN4O5/c1-18(2)38-23-12-11-21(16-22(23)29)30-25-31-26(34)32(13-5-15-37-24-6-3-4-14-36-24)27(35)33(25)17-19-7-9-20(28)10-8-19/h7-12,16,18,24H,3-6,13-15,17H2,1-2H3,(H,30,31,34) PZPBYNVUKMXYIV-UHFFFAOYSA-N 183179 US9150546, I-342::US9688643, I-342::US9718790, I-0342 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183179 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183179&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821045 313634579 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470576 COc1ccc(Cn2c(=O)nc(Nc3ccc(OC(C)C)c(F)c3)n(Cc3ccc(Cl)cc3)c2=O)cc1 InChI=1S/C27H26ClFN4O4/c1-17(2)37-24-13-10-21(14-23(24)29)30-25-31-26(34)33(16-19-6-11-22(36-3)12-7-19)27(35)32(25)15-18-4-8-20(28)9-5-18/h4-14,17H,15-16H2,1-3H3,(H,30,31,34) JVNJNDPHOPMJGS-UHFFFAOYSA-N 183180 US9150546, I-343::US9688643, I-343::US9718790, I-0343 P2X purinoceptor 3 Homo sapiens 21 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183180 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183180&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821071 313634580 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470577 CCCCc1ccc(Nc2nc(=O)n(CCO)c(=O)n2Cc2ccc(Cl)cc2)cc1 InChI=1S/C22H25ClN4O3/c1-2-3-4-16-7-11-19(12-8-16)24-20-25-21(29)26(13-14-28)22(30)27(20)15-17-5-9-18(23)10-6-17/h5-12,28H,2-4,13-15H2,1H3,(H,24,25,29) NFHXSNPUKNDNLC-UHFFFAOYSA-N 183181 US9150546, I-344::US9688643, I-344::US9718790, I-0344 P2X purinoceptor 3 Homo sapiens 128 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183181 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183181&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821446 313634581 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470578 CC(C)Oc1ccc(Nc2nc(=O)n(CC=C)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C22H22ClFN4O3/c1-4-11-27-21(29)26-20(25-17-9-10-19(18(24)12-17)31-14(2)3)28(22(27)30)13-15-5-7-16(23)8-6-15/h4-10,12,14H,1,11,13H2,2-3H3,(H,25,26,29) KVIXRQVJVQCDSK-UHFFFAOYSA-N 183182 US9150546, I-346::US9688643, I-346::US9718790, I-0346 P2X purinoceptor 3 Homo sapiens 16 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183182 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183182&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821368 313634582 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470579 CC(C)Oc1ccc(Nc2nc(=O)n(CCO)c(=O)n2Cc2ccc(cc2)[N+]([O-])=O)cc1F InChI=1S/C21H22FN5O6/c1-13(2)33-18-8-5-15(11-17(18)22)23-19-24-20(29)25(9-10-28)21(30)26(19)12-14-3-6-16(7-4-14)27(31)32/h3-8,11,13,28H,9-10,12H2,1-2H3,(H,23,24,29) VPITVNBBSGONIS-UHFFFAOYSA-N 183183 US9150546, I-347::US9688643, I-347::US9718790, I-0347 P2X purinoceptor 3 Homo sapiens 251 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183183 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183183&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821178 313634583 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470580 CCCn1c(=O)nc(Nc2ccc(OC(C)C)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C22H24ClFN4O3/c1-4-11-27-21(29)26-20(25-17-9-10-19(18(24)12-17)31-14(2)3)28(22(27)30)13-15-5-7-16(23)8-6-15/h5-10,12,14H,4,11,13H2,1-3H3,(H,25,26,29) JPYJUMSFDCRFTJ-UHFFFAOYSA-N 183184 US9150546, I-348::US9688643, I-348::US9718790, I-0348 P2X purinoceptor 3 Homo sapiens 13 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183184 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183184&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821127 313634584 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470581 CCCn1c(=O)nc(Nc2ccc(OC(C)C)c(F)c2)n(Cc2ccccc2)c1=O InChI=1S/C22H25FN4O3/c1-4-12-26-21(28)25-20(27(22(26)29)14-16-8-6-5-7-9-16)24-17-10-11-19(18(23)13-17)30-15(2)3/h5-11,13,15H,4,12,14H2,1-3H3,(H,24,25,28) QOJKTYIYEBVLFQ-UHFFFAOYSA-N 183185 US9150546, I-349::US9688643, I-349::US9718790, I-0349 P2X purinoceptor 3 Homo sapiens 113 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183185 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183185&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821075 313634585 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470582 CC(C)Oc1ccc(Nc2nc(=O)n(CCOC3CCCCO3)c(=O)n2Cc2ccc(Cl)cc2)cc1Cl InChI=1S/C26H30Cl2N4O5/c1-17(2)37-22-11-10-20(15-21(22)28)29-24-30-25(33)31(12-14-36-23-5-3-4-13-35-23)26(34)32(24)16-18-6-8-19(27)9-7-18/h6-11,15,17,23H,3-5,12-14,16H2,1-2H3,(H,29,30,33) HYEDLAYHBGAJBN-UHFFFAOYSA-N 183186 US9150546, I-350::US9688643, I-350::US9718790, I-0350 P2X purinoceptor 3 Homo sapiens 10.00 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183186 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183186&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821217 313634586 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470583 CC(C)Oc1ccc(Nc2nc(=O)n(CCO)c(=O)n2Cc2ccc(Cl)cc2)cc1Cl InChI=1S/C21H22Cl2N4O4/c1-13(2)31-18-8-7-16(11-17(18)23)24-19-25-20(29)26(9-10-28)21(30)27(19)12-14-3-5-15(22)6-4-14/h3-8,11,13,28H,9-10,12H2,1-2H3,(H,24,25,29) LVLPRWHJRHKWQM-UHFFFAOYSA-N 183187 US9150546, I-351::US9688643, I-351::US9718790, I-0351 P2X purinoceptor 3 Homo sapiens 15 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183187 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183187&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821305 313634587 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470584 CC(C)Oc1ccc(Nc2nc(=O)n(CCC(=O)NCCO)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C24H27ClFN5O5/c1-15(2)36-20-8-7-18(13-19(20)26)28-22-29-23(34)30(11-9-21(33)27-10-12-32)24(35)31(22)14-16-3-5-17(25)6-4-16/h3-8,13,15,32H,9-12,14H2,1-2H3,(H,27,33)(H,28,29,34) CWCRNKZFRUTYCW-UHFFFAOYSA-N 183188 US9150546, I-352::US9688643, I-352::US9718790, I-0352 P2X purinoceptor 3 Homo sapiens 36 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183188 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183188&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821100 313634588 C04080 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470585 CC(C)Oc1ccc(Nc2nc(=O)n(CC(=O)NCCO)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C23H25ClFN5O5/c1-14(2)35-19-8-7-17(11-18(19)25)27-21-28-22(33)30(13-20(32)26-9-10-31)23(34)29(21)12-15-3-5-16(24)6-4-15/h3-8,11,14,31H,9-10,12-13H2,1-2H3,(H,26,32)(H,27,28,33) ORMVFHWWSZHFJA-UHFFFAOYSA-N 183189 US9150546, I-353::US9688643, I-353::US9718790, I-0353 P2X purinoceptor 3 Homo sapiens 18 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183189 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183189&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 77888221 313634589 C04080 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470586 CCOC(=O)CCn1c(=O)nc(Nc2ccc(OC(C)C)c(Cl)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H26Cl2N4O5/c1-4-34-21(31)11-12-29-23(32)28-22(27-18-9-10-20(19(26)13-18)35-15(2)3)30(24(29)33)14-16-5-7-17(25)8-6-16/h5-10,13,15H,4,11-12,14H2,1-3H3,(H,27,28,32) VHGWQSUSWLECNQ-UHFFFAOYSA-N 183190 US9150546, I-354::US9688643, I-354::US9718790, I-0354 P2X purinoceptor 3 Homo sapiens 8.00 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183190 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183190&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821037 313634590 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470587 CC(C)Oc1ccc(Nc2nc(=O)n(CCC(O)=O)c(=O)n2Cc2ccc(Cl)cc2)cc1Cl InChI=1S/C22H22Cl2N4O5/c1-13(2)33-18-8-7-16(11-17(18)24)25-20-26-21(31)27(10-9-19(29)30)22(32)28(20)12-14-3-5-15(23)6-4-14/h3-8,11,13H,9-10,12H2,1-2H3,(H,29,30)(H,25,26,31) LTHMPYWKRCESAL-UHFFFAOYSA-N 183191 US9150546, I-355::US9688643, I-355::US9718790, I-0355 P2X purinoceptor 3 Homo sapiens 20 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183191 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183191&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821101 313634591 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470588 CCOC(=O)CCn1c(=O)nc(Nc2ccc(OC(C)C)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H26ClFN4O5/c1-4-34-21(31)11-12-29-23(32)28-22(27-18-9-10-20(19(26)13-18)35-15(2)3)30(24(29)33)14-16-5-7-17(25)8-6-16/h5-10,13,15H,4,11-12,14H2,1-3H3,(H,27,28,32) LDMWUXAYSNMZOT-UHFFFAOYSA-N 183192 US9150546, I-356::US9688643, I-356::US9718790, I-0356 P2X purinoceptor 3 Homo sapiens 12 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183192 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183192&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821391 313634592 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470589 OCCCn1c(=O)nc(Nc2cccc(c2)C(F)(F)F)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C20H18ClF3N4O3/c21-15-7-5-13(6-8-15)12-28-17(26-18(30)27(19(28)31)9-2-10-29)25-16-4-1-3-14(11-16)20(22,23)24/h1,3-8,11,29H,2,9-10,12H2,(H,25,26,30) DOVAEUUVRWPLHI-UHFFFAOYSA-N 183193 US9150546, I-357::US9688643, I-357::US9718790, I-0357 P2X purinoceptor 3 Homo sapiens 47 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183193 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183193&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821023 313634593 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470590 CC(C)Cc1ccc(Nc2nc(=O)n(CCCO)c(=O)n2Cc2ccc(Cl)cc2)cc1 InChI=1S/C23H27ClN4O3/c1-16(2)14-17-6-10-20(11-7-17)25-21-26-22(30)27(12-3-13-29)23(31)28(21)15-18-4-8-19(24)9-5-18/h4-11,16,29H,3,12-15H2,1-2H3,(H,25,26,30) KQESQAJPTWDTMT-UHFFFAOYSA-N 183194 US9150546, I-358::US9688643, I-358::US9718790, I-0358 P2X purinoceptor 3 Homo sapiens 55 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183194 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183194&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821234 313634594 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470591 CC(C)Oc1ccc(Nc2nc(=O)n(CCCO)c(=O)n2Cc2ccc(Cl)cc2)cc1 InChI=1S/C22H25ClN4O4/c1-15(2)31-19-10-8-18(9-11-19)24-20-25-21(29)26(12-3-13-28)22(30)27(20)14-16-4-6-17(23)7-5-16/h4-11,15,28H,3,12-14H2,1-2H3,(H,24,25,29) XMOQRFWNARHCLH-UHFFFAOYSA-N 183195 US9150546, I-359::US9688643, I-359::US9718790, I-0359 P2X purinoceptor 3 Homo sapiens 40 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183195 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183195&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821252 313634595 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470592 OCCCn1c(=O)nc(Nc2ccc(OC(F)F)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C20H19ClF2N4O4/c21-14-4-2-13(3-5-14)12-27-18(25-19(29)26(20(27)30)10-1-11-28)24-15-6-8-16(9-7-15)31-17(22)23/h2-9,17,28H,1,10-12H2,(H,24,25,29) YRRWZMDHZPCEJW-UHFFFAOYSA-N 183196 US9150546, I-360::US9688643, I-360::US9718790, I-0360 P2X purinoceptor 3 Homo sapiens 148 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183196 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183196&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821343 313634596 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470593 CCOc1ccc(Nc2nc(=O)n(CCCO)c(=O)n2Cc2ccc(Cl)cc2)cc1 InChI=1S/C21H23ClN4O4/c1-2-30-18-10-8-17(9-11-18)23-19-24-20(28)25(12-3-13-27)21(29)26(19)14-15-4-6-16(22)7-5-15/h4-11,27H,2-3,12-14H2,1H3,(H,23,24,28) MQGOIKGFIRWKLK-UHFFFAOYSA-N 183197 US9150546, I-361::US9688643, I-361::US9718790, I-0361 P2X purinoceptor 3 Homo sapiens 76 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183197 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183197&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821375 313634597 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470594 CC(C)Oc1ccc(Nc2nc(=O)n(CCCO)c(=O)n2Cc2ccc(Cl)cc2)cc1Cl InChI=1S/C22H24Cl2N4O4/c1-14(2)32-19-9-8-17(12-18(19)24)25-20-26-21(30)27(10-3-11-29)22(31)28(20)13-15-4-6-16(23)7-5-15/h4-9,12,14,29H,3,10-11,13H2,1-2H3,(H,25,26,30) CGVREEYRNJNDLQ-UHFFFAOYSA-N 183198 US9150546, I-362::US9688643, I-362::US9718790, I-0362 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183198 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183198&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821189 313634598 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470595 CC(C)Oc1ccc(Nc2nc(=O)n(CCCC(O)=O)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C23H24ClFN4O5/c1-14(2)34-19-10-9-17(12-18(19)25)26-21-27-22(32)28(11-3-4-20(30)31)23(33)29(21)13-15-5-7-16(24)8-6-15/h5-10,12,14H,3-4,11,13H2,1-2H3,(H,30,31)(H,26,27,32) PRGQUPCLZCUZSW-UHFFFAOYSA-N 183199 US9150546, I-363::US9688643, I-363::US9718790, I-0363 P2X purinoceptor 3 Homo sapiens 78 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183199 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183199&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821307 313634599 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470596 CC(C)Oc1ccc(Nc2nc(=O)n(CC(C)(C)C(O)=O)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C24H26ClFN4O5/c1-14(2)35-19-10-9-17(11-18(19)26)27-21-28-22(33)30(13-24(3,4)20(31)32)23(34)29(21)12-15-5-7-16(25)8-6-15/h5-11,14H,12-13H2,1-4H3,(H,31,32)(H,27,28,33) CAYYASMSWISXDA-UHFFFAOYSA-N 183200 US9150546, I-364::US9688643, I-364::US9718790, I-0364 P2X purinoceptor 3 Homo sapiens 30 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183200 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183200&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821363 313634600 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470597 CC(C)Oc1ccc(Nc2nc(=O)n(CCCCO)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C23H26ClFN4O4/c1-15(2)33-20-10-9-18(13-19(20)25)26-21-27-22(31)28(11-3-4-12-30)23(32)29(21)14-16-5-7-17(24)8-6-16/h5-10,13,15,30H,3-4,11-12,14H2,1-2H3,(H,26,27,31) WIVQLHRBUYZELM-UHFFFAOYSA-N 183201 US9150546, I-365::US9688643, I-365::US9718790, I-0365 P2X purinoceptor 3 Homo sapiens 18 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183201 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183201&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821405 313634601 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470598 CC(C)Cc1ccc(Nc2nc(=O)n(CC(CO)CO)c(=O)n2Cc2ccc(Cl)cc2)cc1 InChI=1S/C24H29ClN4O4/c1-16(2)11-17-5-9-21(10-6-17)26-22-27-23(32)29(13-19(14-30)15-31)24(33)28(22)12-18-3-7-20(25)8-4-18/h3-10,16,19,30-31H,11-15H2,1-2H3,(H,26,27,32) DKYDIWXEJZFVMN-UHFFFAOYSA-N 183202 US9150546, I-366::US9688643, I-366::US9718790, I-0366 P2X purinoceptor 3 Homo sapiens 46 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183202 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183202&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821182 313634602 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470599 OCC(CO)Cn1c(=O)nc(Nc2cccc(c2)C(F)(F)F)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C21H20ClF3N4O4/c22-16-6-4-13(5-7-16)9-28-18(26-17-3-1-2-15(8-17)21(23,24)25)27-19(32)29(20(28)33)10-14(11-30)12-31/h1-8,14,30-31H,9-12H2,(H,26,27,32) KCPABKMRFNAYPP-UHFFFAOYSA-N 183203 US9150546, I-367::US9688643, I-367::US9718790, I-0367 P2X purinoceptor 3 Homo sapiens 40 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183203 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183203&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821236 313634603 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470600 CC(C)Oc1ccc(Nc2nc(=O)n(CC(CO)CO)c(=O)n2Cc2ccc(Cl)cc2)cc1 InChI=1S/C23H27ClN4O5/c1-15(2)33-20-9-7-19(8-10-20)25-21-26-22(31)28(12-17(13-29)14-30)23(32)27(21)11-16-3-5-18(24)6-4-16/h3-10,15,17,29-30H,11-14H2,1-2H3,(H,25,26,31) RWDNKWAXZYGNOK-UHFFFAOYSA-N 183204 US9150546, I-368::US9688643, I-368::US9718790, I-0368 P2X purinoceptor 3 Homo sapiens 41 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183204 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183204&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821424 313634604 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470601 CC(C)Oc1ccc(Nc2nc(=O)n(CC(CO)CO)c(=O)n2Cc2ccc(Cl)cc2)cc1Cl InChI=1S/C23H26Cl2N4O5/c1-14(2)34-20-8-7-18(9-19(20)25)26-21-27-22(32)29(11-16(12-30)13-31)23(33)28(21)10-15-3-5-17(24)6-4-15/h3-9,14,16,30-31H,10-13H2,1-2H3,(H,26,27,32) PLKBMAZPUXNVOD-UHFFFAOYSA-N 183205 US9150546, I-369::US9688643, I-369::US9718790, I-0369 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183205 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183205&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821090 313634605 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470602 OCC(CO)Cn1c(=O)nc(Nc2ccc(OC(F)F)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C21H21ClF2N4O5/c22-15-3-1-13(2-4-15)9-27-19(25-16-5-7-17(8-6-16)33-18(23)24)26-20(31)28(21(27)32)10-14(11-29)12-30/h1-8,14,18,29-30H,9-12H2,(H,25,26,31) ZMQLRXDQQRWLTK-UHFFFAOYSA-N 183206 US9150546, I-370::US9688643, I-370::US9718790, I-0370 P2X purinoceptor 3 Homo sapiens 154 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183206 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183206&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821298 313634606 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470603 CCOc1ccc(Nc2nc(=O)n(CC(CO)CO)c(=O)n2Cc2ccc(Cl)cc2)cc1 InChI=1S/C22H25ClN4O5/c1-2-32-19-9-7-18(8-10-19)24-20-25-21(30)27(12-16(13-28)14-29)22(31)26(20)11-15-3-5-17(23)6-4-15/h3-10,16,28-29H,2,11-14H2,1H3,(H,24,25,30) YVGBOPHKOBITOP-UHFFFAOYSA-N 183207 US9150546, I-371::US9688643, I-371::US9718790, I-0371 P2X purinoceptor 3 Homo sapiens 63 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183207 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183207&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821436 313634607 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470604 CC(C)n1c(=O)nc(Nc2ccc(cc2)C#N)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C20H18ClN5O2/c1-13(2)26-19(27)24-18(23-17-9-5-14(11-22)6-10-17)25(20(26)28)12-15-3-7-16(21)8-4-15/h3-10,13H,12H2,1-2H3,(H,23,24,27) NZRBAYNKFGYVJA-UHFFFAOYSA-N 183208 US9150546, I-372::US9688643, I-372::US9718790, I-0372 P2X purinoceptor 3 Homo sapiens 964 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183208 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183208&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821062 313634608 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470605 OCCn1c(=O)nc(Nc2ccc(Cl)c(Cl)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C18H15Cl3N4O3/c19-12-3-1-11(2-4-12)10-25-16(22-13-5-6-14(20)15(21)9-13)23-17(27)24(7-8-26)18(25)28/h1-6,9,26H,7-8,10H2,(H,22,23,27) TYTCSKQWLRQJSW-UHFFFAOYSA-N 183209 US9150546, I-373::US9688643, I-373::US9718790, I-0373 P2X purinoceptor 3 Homo sapiens 185 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183209 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183209&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821272 313634609 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470606 OCCn1c(=O)nc(Nc2ccc(OC3CCCC3)c(Cl)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H24Cl2N4O4/c24-16-7-5-15(6-8-16)14-29-21(27-22(31)28(11-12-30)23(29)32)26-17-9-10-20(19(25)13-17)33-18-3-1-2-4-18/h5-10,13,18,30H,1-4,11-12,14H2,(H,26,27,31) DLYUERWZMWXDRU-UHFFFAOYSA-N 183210 US9150546, I-374::US9688643, I-374::US9718790, I-0374 P2X purinoceptor 3 Homo sapiens 80 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183210 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183210&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821239 313634610 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470607 OCCn1c(=O)nc(Nc2ccc(OC(F)F)c(Cl)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C19H16Cl2F2N4O4/c20-12-3-1-11(2-4-12)10-27-17(25-18(29)26(7-8-28)19(27)30)24-13-5-6-15(14(21)9-13)31-16(22)23/h1-6,9,16,28H,7-8,10H2,(H,24,25,29) YCBOZBOYAOUFQO-UHFFFAOYSA-N 183211 US9150546, I-375::US9688643, I-375::US9718790, I-0375 P2X purinoceptor 3 Homo sapiens 152 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183211 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183211&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821378 313634611 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470608 CS(=O)(=O)Cc1ccc(Nc2nc(=O)n(CCO)c(=O)n2Cc2ccc(Cl)cc2)cc1 InChI=1S/C20H21ClN4O5S/c1-31(29,30)13-15-4-8-17(9-5-15)22-18-23-19(27)24(10-11-26)20(28)25(18)12-14-2-6-16(21)7-3-14/h2-9,26H,10-13H2,1H3,(H,22,23,27) XZEFBCOKWDMSGB-UHFFFAOYSA-N 168573 US9688643, I-377 P2X purinoceptor 3 Homo sapiens 755 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168573 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168573&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821145 363891441 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470609 CC(C)c1cccc(Nc2nc(=O)n(CCO)c(=O)n2Cc2ccc(Cl)cc2)c1 InChI=1S/C21H23ClN4O3/c1-14(2)16-4-3-5-18(12-16)23-19-24-20(28)25(10-11-27)21(29)26(19)13-15-6-8-17(22)9-7-15/h3-9,12,14,27H,10-11,13H2,1-2H3,(H,23,24,28) HHUYYWJOWGZXNS-UHFFFAOYSA-N 183213 US9150546, I-378::US9688643, I-378::US9718790, I-0378 P2X purinoceptor 3 Homo sapiens 347 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183213 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183213&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821174 313634613 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470610 CCCSc1ccc(Nc2nc(=O)n(CCO)c(=O)n2Cc2ccc(Cl)cc2)cc1 InChI=1S/C21H23ClN4O3S/c1-2-13-30-18-9-7-17(8-10-18)23-19-24-20(28)25(11-12-27)21(29)26(19)14-15-3-5-16(22)6-4-15/h3-10,27H,2,11-14H2,1H3,(H,23,24,28) WSXYIBMUMGPQNK-UHFFFAOYSA-N 183214 US9150546, I-379::US9688643, I-379::US9718790, I-0379 P2X purinoceptor 3 Homo sapiens 330 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183214 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183214&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821173 313634614 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470611 CCOC(=O)CCn1c(=O)nc(Nc2ccc(OC(C)C)c(Cl)c2)n(CC2CCCCC2)c1=O InChI=1S/C24H33ClN4O5/c1-4-33-21(30)12-13-28-23(31)27-22(29(24(28)32)15-17-8-6-5-7-9-17)26-18-10-11-20(19(25)14-18)34-16(2)3/h10-11,14,16-17H,4-9,12-13,15H2,1-3H3,(H,26,27,31) NMXZCGVWTFHWPD-UHFFFAOYSA-N 183215 US9150546, I-380::US9688643, I-380::US9718790, I-0380 P2X purinoceptor 3 Homo sapiens 34 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183215 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183215&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821211 313634615 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470612 CC(C)Oc1ccc(Nc2nc(=O)n(CCC(O)=O)c(=O)n2CC2CCCCC2)cc1Cl InChI=1S/C22H29ClN4O5/c1-14(2)32-18-9-8-16(12-17(18)23)24-20-25-21(30)26(11-10-19(28)29)22(31)27(20)13-15-6-4-3-5-7-15/h8-9,12,14-15H,3-7,10-11,13H2,1-2H3,(H,28,29)(H,24,25,30) QKIBFGFDLISDQM-UHFFFAOYSA-N 183216 US9150546, I-382::US9688643, I-382::US9718790, I-0382 P2X purinoceptor 3 Homo sapiens 96 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183216 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183216&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821152 313634616 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470613 OCCn1c(=O)nc(Nc2ccc(OC(F)(F)F)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C19H16ClF3N4O4/c20-13-3-1-12(2-4-13)11-27-16(25-17(29)26(9-10-28)18(27)30)24-14-5-7-15(8-6-14)31-19(21,22)23/h1-8,28H,9-11H2,(H,24,25,29) SPZDSFVDXNQRAX-UHFFFAOYSA-N 183217 US9150546, I-383::US9688643, I-383::US9718790, I-0383 P2X purinoceptor 3 Homo sapiens 532 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183217 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183217&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821098 313634617 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470614 CCCS(=O)c1ccc(Nc2nc(=O)n(CCO)c(=O)n2Cc2ccc(Cl)cc2)cc1 InChI=1S/C21H23ClN4O4S/c1-2-13-31(30)18-9-7-17(8-10-18)23-19-24-20(28)25(11-12-27)21(29)26(19)14-15-3-5-16(22)6-4-15/h3-10,27H,2,11-14H2,1H3,(H,23,24,28) OTAYHRITIADLTG-UHFFFAOYSA-N 183218 US9150546, I-385::US9688643, I-385::US9718790, I-0385 P2X purinoceptor 3 Homo sapiens 908 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183218 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183218&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821286 313634618 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470615 CC(C)Oc1ccc(Nc2nc(=O)n(CCNC(N)=O)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C22H24ClFN6O4/c1-13(2)34-18-8-7-16(11-17(18)24)27-20-28-21(32)29(10-9-26-19(25)31)22(33)30(20)12-14-3-5-15(23)6-4-14/h3-8,11,13H,9-10,12H2,1-2H3,(H3,25,26,31)(H,27,28,32) WGRJWKPPVJDRMX-UHFFFAOYSA-N 183219 US9150546, I-386::US9688643, I-386::US9718790, I-0386 P2X purinoceptor 3 Homo sapiens 41 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183219 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183219&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 77888201 313634619 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470616 CNC(=O)NCCn1c(=O)nc(Nc2ccc(OC(C)C)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H26ClFN6O4/c1-14(2)35-19-9-8-17(12-18(19)25)28-20-29-22(33)30(11-10-27-21(32)26-3)23(34)31(20)13-15-4-6-16(24)7-5-15/h4-9,12,14H,10-11,13H2,1-3H3,(H2,26,27,32)(H,28,29,33) GBKQOARKSUDDPS-UHFFFAOYSA-N 183220 US9150546, I-387::US9688643, I-387::US9718790, I-0387 P2X purinoceptor 3 Homo sapiens 37 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183220 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183220&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 77387734 313634620 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470617 CC(C)Oc1ccc(Nc2nc(=O)n(CCNC(=O)N(C)C)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C24H28ClFN6O4/c1-15(2)36-20-10-9-18(13-19(20)26)28-21-29-23(34)31(12-11-27-22(33)30(3)4)24(35)32(21)14-16-5-7-17(25)8-6-16/h5-10,13,15H,11-12,14H2,1-4H3,(H,27,33)(H,28,29,34) LQVUMSPACOUIKQ-UHFFFAOYSA-N 183221 US9150546, I-388::US9688643, I-388::US9718790, I-0388 P2X purinoceptor 3 Homo sapiens 36 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183221 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183221&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 77888222 313634621 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470618 CCNC(=O)NCCn1c(=O)nc(Nc2ccc(OC(C)C)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H28ClFN6O4/c1-4-27-22(33)28-11-12-31-23(34)30-21(29-18-9-10-20(19(26)13-18)36-15(2)3)32(24(31)35)14-16-5-7-17(25)8-6-16/h5-10,13,15H,4,11-12,14H2,1-3H3,(H2,27,28,33)(H,29,30,34) OPMCGYFGAQSGMM-UHFFFAOYSA-N 183222 US9150546, I-389::US9688643, I-389::US9718790, I-0389 P2X purinoceptor 3 Homo sapiens 64 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183222 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183222&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 77387733 313634622 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470619 CC(C)Oc1ccc(Nc2nc(=O)n(CCNC(=O)NCCO)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C24H28ClFN6O5/c1-15(2)37-20-8-7-18(13-19(20)26)29-21-30-23(35)31(11-9-27-22(34)28-10-12-33)24(36)32(21)14-16-3-5-17(25)6-4-16/h3-8,13,15,33H,9-12,14H2,1-2H3,(H2,27,28,34)(H,29,30,35) UYTSYZVVZRWWPG-UHFFFAOYSA-N 183223 US9150546, I-390::US9688643, I-390::US9718790, I-0390 P2X purinoceptor 3 Homo sapiens 67 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183223 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183223&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 77888253 313634623 C04080 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470620 CC(C)Oc1ccc(Nc2nc(=O)n(CCN3C(=O)CNC3=O)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C24H24ClFN6O5/c1-14(2)37-19-8-7-17(11-18(19)26)28-21-29-23(35)31(10-9-30-20(33)12-27-22(30)34)24(36)32(21)13-15-3-5-16(25)6-4-15/h3-8,11,14H,9-10,12-13H2,1-2H3,(H,27,34)(H,28,29,35) VXBIJNZVTIYGOG-UHFFFAOYSA-N 183224 US9150546, I-391::US9688643, I-391::US9718790, I-0391 P2X purinoceptor 3 Homo sapiens 133 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183224 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183224&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821069 313634624 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470621 CC(C)Oc1ccc(Nc2nc(=O)n(CCNC(=O)NCC(O)=O)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C24H26ClFN6O6/c1-14(2)38-19-8-7-17(11-18(19)26)29-21-30-23(36)31(10-9-27-22(35)28-12-20(33)34)24(37)32(21)13-15-3-5-16(25)6-4-15/h3-8,11,14H,9-10,12-13H2,1-2H3,(H,33,34)(H2,27,28,35)(H,29,30,36) DNZVQLZWGVMZRF-UHFFFAOYSA-N 183225 US9150546, I-392::US9688643, I-392::US9718790, I-0392 P2X purinoceptor 3 Homo sapiens 38 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183225 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183225&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 77388921 313634625 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470622 CC(C)Oc1ccc(Nc2nc(=O)n(C(C)C)c(=O)n2Cc2ccc(Cl)cc2)cn1 InChI=1S/C21H24ClN5O3/c1-13(2)27-20(28)25-19(24-17-9-10-18(23-11-17)30-14(3)4)26(21(27)29)12-15-5-7-16(22)8-6-15/h5-11,13-14H,12H2,1-4H3,(H,24,25,28) ADLQECFGSXQFRO-UHFFFAOYSA-N 183226 US9150546, I-394::US9688643, I-394::US9718790, I-0394 P2X purinoceptor 3 Homo sapiens 435 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183226 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183226&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821185 313634626 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470623 COC(=O)CNC(=O)Cn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H25ClFN5O6/c1-14(2)37-19-9-8-17(10-18(19)26)28-22-29-23(34)31(13-20(32)27-11-21(33)36-3)24(35)30(22)12-15-4-6-16(25)7-5-15/h4-10,14H,11-13H2,1-3H3,(H,27,32)(H,28,29,34) RNYCCLDACFSVPF-UHFFFAOYSA-N 183227 US9150546, I-397::US9688643, I-397::US9718790, I-0396 P2X purinoceptor 3 Homo sapiens 19 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183227 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183227&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 70645186 313634627 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470624 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n(CC(=O)NC(CO)CO)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C24H27ClFN5O6/c1-14(2)37-20-8-7-17(9-19(20)26)28-22-29-23(35)31(11-21(34)27-18(12-32)13-33)24(36)30(22)10-15-3-5-16(25)6-4-15/h3-9,14,18,32-33H,10-13H2,1-2H3,(H,27,34)(H,28,29,35) QLEUXCJJSFSQEI-UHFFFAOYSA-N 183228 US9150546, I-398::US9688643, I-398::US9718790, I-0397 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183228 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183228&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 70645174 313634628 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470625 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(Cl)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H28Cl2N4O5/c1-15(2)36-20-11-10-18(12-19(20)27)28-22-29-23(33)31(14-25(3,4)21(32)35-5)24(34)30(22)13-16-6-8-17(26)9-7-16/h6-12,15H,13-14H2,1-5H3,(H,28,29,33) NEGZBMXAYHSDHD-UHFFFAOYSA-N 183229 US9150546, I-399::US9688643, I-399::US9718790, I-0398 P2X purinoceptor 3 Homo sapiens 8.00 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183229 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183229&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578721 313634629 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470626 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n(CC(=O)NCC(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C23H23ClFN5O6/c1-13(2)36-18-8-7-16(9-17(18)25)27-21-28-22(34)30(12-19(31)26-10-20(32)33)23(35)29(21)11-14-3-5-15(24)6-4-14/h3-9,13H,10-12H2,1-2H3,(H,26,31)(H,32,33)(H,27,28,34) YMEDLYRRZUJVPG-UHFFFAOYSA-N 183230 US9150546, I-400::US9688643, I-400::US9718790, I-0399 P2X purinoceptor 3 Homo sapiens 44 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183230 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183230&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 70645141 313634630 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470627 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C24H26Cl2N4O5/c1-14(2)35-19-10-9-17(11-18(19)26)27-21-28-22(33)30(13-24(3,4)20(31)32)23(34)29(21)12-15-5-7-16(25)8-6-15/h5-11,14H,12-13H2,1-4H3,(H,31,32)(H,27,28,33) JBUWYWPQCDLCBD-UHFFFAOYSA-N 183231 US9150546, I-401::US9688643, I-401::US9718790, I-0400 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183231 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183231&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578683 313634631 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470628 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(cc2)C(=O)C(C)(C)C)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C27H31ClN4O5/c1-26(2,3)21(33)18-9-13-20(14-10-18)29-23-30-24(35)32(16-27(4,5)22(34)37-6)25(36)31(23)15-17-7-11-19(28)12-8-17/h7-14H,15-16H2,1-6H3,(H,29,30,35) SNQFHIXRJZIARK-UHFFFAOYSA-N 183232 US9150546, I-402::US9688643, I-402::US9718790, I-0401 P2X purinoceptor 3 Homo sapiens 443 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183232 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183232&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578510 313634632 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470629 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H28ClFN4O5/c1-15(2)36-20-11-10-18(12-19(20)27)28-22-29-23(33)31(14-25(3,4)21(32)35-5)24(34)30(22)13-16-6-8-17(26)9-7-16/h6-12,15H,13-14H2,1-5H3,(H,28,29,33) HZQKRSDENBOLOY-UHFFFAOYSA-N 183233 US9150546, I-403::US9688643, I-403::US9718790, I-0402 P2X purinoceptor 3 Homo sapiens 15 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183233 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183233&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578492 313634633 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470630 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(F)c2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C26H31FN4O5/c1-16(2)36-21-12-11-19(13-20(21)27)28-23-29-24(33)31(15-26(4,5)22(32)35-6)25(34)30(23)14-18-9-7-17(3)8-10-18/h7-13,16H,14-15H2,1-6H3,(H,28,29,33) MRSBPJQMAXBIJN-UHFFFAOYSA-N 183234 US9150546, I-404::US9688643, I-404::US9718790, I-0403 P2X purinoceptor 3 Homo sapiens 12 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183234 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183234&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578473 313634634 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470631 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n1Cc1ccc(C)cc1 InChI=1S/C25H29FN4O5/c1-15(2)35-20-11-10-18(12-19(20)26)27-22-28-23(33)30(14-25(4,5)21(31)32)24(34)29(22)13-17-8-6-16(3)7-9-17/h6-12,15H,13-14H2,1-5H3,(H,31,32)(H,27,28,33) LJWOBZNJMCMRLJ-UHFFFAOYSA-N 183235 US9150546, I-405::US9688643, I-405::US9718790, I-0404 P2X purinoceptor 3 Homo sapiens 32 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183235 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183235&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578628 313634635 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470632 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n(CCC(C)(C)C(=O)OCc2ccccc2)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C32H34ClFN4O5/c1-21(2)43-27-15-14-25(18-26(27)34)35-29-36-30(40)37(31(41)38(29)19-22-10-12-24(33)13-11-22)17-16-32(3,4)28(39)42-20-23-8-6-5-7-9-23/h5-15,18,21H,16-17,19-20H2,1-4H3,(H,35,36,40) TUOYSYBZHUPNQN-UHFFFAOYSA-N 183236 US9150546, I-406::US9688643, I-406::US9718790, I-0405 P2X purinoceptor 3 Homo sapiens 30 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183236 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183236&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578501 313634636 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470633 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(CCC(C)(C)C(=O)OCc2ccccc2)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C32H34Cl2N4O5/c1-21(2)43-27-15-14-25(18-26(27)34)35-29-36-30(40)37(31(41)38(29)19-22-10-12-24(33)13-11-22)17-16-32(3,4)28(39)42-20-23-8-6-5-7-9-23/h5-15,18,21H,16-17,19-20H2,1-4H3,(H,35,36,40) OOPDFVLJBFXGIN-UHFFFAOYSA-N 183237 US9150546, I-407::US9688643, I-407::US9718790, I-0406 P2X purinoceptor 3 Homo sapiens 27 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183237 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183237&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578925 313634637 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470634 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n1Cc1ccc(C)cc1 InChI=1S/C25H29ClN4O5/c1-15(2)35-20-11-10-18(12-19(20)26)27-22-28-23(33)30(14-25(4,5)21(31)32)24(34)29(22)13-17-8-6-16(3)7-9-17/h6-12,15H,13-14H2,1-5H3,(H,31,32)(H,27,28,33) IEFCYNPWRFXORF-UHFFFAOYSA-N 183238 US9150546, I-408::US9688643, I-408::US9718790, I-0407 P2X purinoceptor 3 Homo sapiens 10.00 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183238 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183238&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578596 313634638 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470635 COC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(F)c2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C24H27FN4O5/c1-15(2)34-20-10-9-18(13-19(20)25)26-22-27-23(31)28(12-11-21(30)33-4)24(32)29(22)14-17-7-5-16(3)6-8-17/h5-10,13,15H,11-12,14H2,1-4H3,(H,26,27,31) PHPQOSGTOXGNRQ-UHFFFAOYSA-N 183239 US9150546, I-409::US9688643, I-409::US9718790, I-0408 P2X purinoceptor 3 Homo sapiens 12 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183239 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183239&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578582 313634639 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470636 COC(=O)Cn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(F)c2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C23H25FN4O5/c1-14(2)33-19-10-9-17(11-18(19)24)25-21-26-22(30)28(13-20(29)32-4)23(31)27(21)12-16-7-5-15(3)6-8-16/h5-11,14H,12-13H2,1-4H3,(H,25,26,30) WSLNIUFYXOOLNG-UHFFFAOYSA-N 183240 US9150546, I-410::US9688643, I-410::US9718790, I-0409 P2X purinoceptor 3 Homo sapiens 44 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183240 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183240&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578811 313634640 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470637 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n(CCC(O)=O)c(=O)n1Cc1ccc(C)cc1 InChI=1S/C23H25FN4O5/c1-14(2)33-19-9-8-17(12-18(19)24)25-21-26-22(31)27(11-10-20(29)30)23(32)28(21)13-16-6-4-15(3)5-7-16/h4-9,12,14H,10-11,13H2,1-3H3,(H,29,30)(H,25,26,31) ISLQRXSYZCSMAZ-UHFFFAOYSA-N 183241 US9150546, I-411::US9688643, I-411::US9718790, I-0410 P2X purinoceptor 3 Homo sapiens 61 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183241 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183241&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578680 313634641 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470638 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n1Cc1ccc(C)c(F)c1 InChI=1S/C25H28F2N4O5/c1-14(2)36-20-9-8-17(11-19(20)27)28-22-29-23(34)31(13-25(4,5)21(32)33)24(35)30(22)12-16-7-6-15(3)18(26)10-16/h6-11,14H,12-13H2,1-5H3,(H,32,33)(H,28,29,34) IBIXQPAHELGEQO-UHFFFAOYSA-N 183242 US9150546, I-413::US9688643, I-413::US9718790, I-0412 P2X purinoceptor 3 Homo sapiens 99 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183242 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183242&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578614 313634642 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470639 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n(CC(=O)NC(CO)CO)c(=O)n1Cc1ccc(C)cc1 InChI=1S/C25H30FN5O6/c1-15(2)37-21-9-8-18(10-20(21)26)28-23-29-24(35)31(12-22(34)27-19(13-32)14-33)25(36)30(23)11-17-6-4-16(3)5-7-17/h4-10,15,19,32-33H,11-14H2,1-3H3,(H,27,34)(H,28,29,35) UEHTZRMWTIRNBJ-UHFFFAOYSA-N 183243 US9150546, I-414::US9688643, I-414::US9718790, I-0413 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183243 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183243&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 70645185 313634643 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470640 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n(CC(=O)NC(C)(C)C(O)=O)c(=O)n1Cc1ccc(C)cc1 InChI=1S/C26H30FN5O6/c1-15(2)38-20-11-10-18(12-19(20)27)28-23-29-24(36)32(14-21(33)30-26(4,5)22(34)35)25(37)31(23)13-17-8-6-16(3)7-9-17/h6-12,15H,13-14H2,1-5H3,(H,30,33)(H,34,35)(H,28,29,36) NTTJRMLBZJXKKV-UHFFFAOYSA-N 183244 US9150546, I-415::US9688643, I-415::US9718790, I-0414 P2X purinoceptor 3 Homo sapiens 314 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183244 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183244&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020931 313634644 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470641 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n(CC(=O)NCC(O)=O)c(=O)n1Cc1ccc(C)cc1 InChI=1S/C24H26FN5O6/c1-14(2)36-19-9-8-17(10-18(19)25)27-22-28-23(34)30(13-20(31)26-11-21(32)33)24(35)29(22)12-16-6-4-15(3)5-7-16/h4-10,14H,11-13H2,1-3H3,(H,26,31)(H,32,33)(H,27,28,34) FEDTXBHBTVGDMW-UHFFFAOYSA-N 183245 US9150546, I-416::US9688643, I-416::US9718790, I-0415 P2X purinoceptor 3 Homo sapiens 35 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183245 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183245&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 70645146 313634645 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470642 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n(CC(=O)N[C@H](C)C(O)=O)c(=O)n1Cc1ccc(C)cc1 183246 US9150546, I-417::US9688643, I-417::US9718790, I-0416 P2X purinoceptor 3 Homo sapiens 35 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183246 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183246&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 70645187 313634646 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470643 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n(CC(=O)N[C@@H](C)C(O)=O)c(=O)n1Cc1ccc(C)cc1 183247 US9150546, I-418::US9688643, I-418::US9718790, I-0417 P2X purinoceptor 3 Homo sapiens 200 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183247 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183247&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 70645188 313634647 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470644 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n(CC(=O)NC2(CC2)C(O)=O)c(=O)n1Cc1ccc(C)cc1 InChI=1S/C26H28FN5O6/c1-15(2)38-20-9-8-18(12-19(20)27)28-23-29-24(36)32(14-21(33)30-26(10-11-26)22(34)35)25(37)31(23)13-17-6-4-16(3)5-7-17/h4-9,12,15H,10-11,13-14H2,1-3H3,(H,30,33)(H,34,35)(H,28,29,36) FYJMAFNQGXRCEC-UHFFFAOYSA-N 183248 US9150546, I-419::US9688643, I-419::US9718790, I-0418 P2X purinoceptor 3 Homo sapiens 71 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183248 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183248&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020393 313634648 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470645 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n(CCC(C)(C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C25H28ClFN4O5/c1-15(2)36-20-10-9-18(13-19(20)27)28-22-29-23(34)30(12-11-25(3,4)21(32)33)24(35)31(22)14-16-5-7-17(26)8-6-16/h5-10,13,15H,11-12,14H2,1-4H3,(H,32,33)(H,28,29,34) GXZHRQJRSCDCAT-UHFFFAOYSA-N 183249 US9150546, I-420::US9688643, I-420::US9718790, I-0419 P2X purinoceptor 3 Homo sapiens 53 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183249 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183249&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578915 313634649 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470646 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(CCC(C)(C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C25H28Cl2N4O5/c1-15(2)36-20-10-9-18(13-19(20)27)28-22-29-23(34)30(12-11-25(3,4)21(32)33)24(35)31(22)14-16-5-7-17(26)8-6-16/h5-10,13,15H,11-12,14H2,1-4H3,(H,32,33)(H,28,29,34) PIKUFVDOUKAUFW-UHFFFAOYSA-N 183250 US9150546, I-421::US9688643, I-421::US9718790, I-0420 P2X purinoceptor 3 Homo sapiens 19 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183250 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183250&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578771 313634650 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470647 CCOC(=O)C1(Cn2c(=O)[nH]\c(=N/c3ccc(OC(C)C)c(F)c3)n(Cc3ccc(Cl)cc3)c2=O)CC1 InChI=1S/C26H28ClFN4O5/c1-4-36-22(33)26(11-12-26)15-32-24(34)30-23(29-19-9-10-21(20(28)13-19)37-16(2)3)31(25(32)35)14-17-5-7-18(27)8-6-17/h5-10,13,16H,4,11-12,14-15H2,1-3H3,(H,29,30,34) RNAJCWWHBFPQGC-UHFFFAOYSA-N 183251 US9150546, I-422::US9688643, I-422::US9718790, I-0421 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183251 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183251&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578741 313634651 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470648 CCOC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(Cl)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H26Cl2N4O5/c1-4-34-21(31)11-12-29-23(32)28-22(27-18-9-10-20(19(26)13-18)35-15(2)3)30(24(29)33)14-16-5-7-17(25)8-6-16/h5-10,13,15H,4,11-12,14H2,1-3H3,(H,27,28,32) VHGWQSUSWLECNQ-UHFFFAOYSA-N 169213 US9688643, I-423 P2X purinoceptor 3 Homo sapiens 4.00 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=169213 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=169213&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578474 363891481 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470649 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n(CC2(CC2)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C24H24ClFN4O5/c1-14(2)35-19-8-7-17(11-18(19)26)27-21-28-22(33)30(13-24(9-10-24)20(31)32)23(34)29(21)12-15-3-5-16(25)6-4-15/h3-8,11,14H,9-10,12-13H2,1-2H3,(H,31,32)(H,27,28,33) SEXDOMXDYBZSNF-UHFFFAOYSA-N 183253 US9150546, I-424::US9688643, I-424::US9718790, I-0423 P2X purinoceptor 3 Homo sapiens 49 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183253 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183253&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578524 313634653 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470650 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(CC2(CC2)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C24H24Cl2N4O5/c1-14(2)35-19-8-7-17(11-18(19)26)27-21-28-22(33)30(13-24(9-10-24)20(31)32)23(34)29(21)12-15-3-5-16(25)6-4-15/h3-8,11,14H,9-10,12-13H2,1-2H3,(H,31,32)(H,27,28,33) HBBCEZGDISQHSJ-UHFFFAOYSA-N 183254 US9150546, I-425::US9688643, I-425::US9718790, I-0424 P2X purinoceptor 3 Homo sapiens 16 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183254 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183254&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578673 313634654 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470651 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(O)c(Cl)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C22H22Cl2N4O5/c1-22(2,18(30)33-3)12-28-20(31)26-19(25-15-8-9-17(29)16(24)10-15)27(21(28)32)11-13-4-6-14(23)7-5-13/h4-10,29H,11-12H2,1-3H3,(H,25,26,31) SXOZPGVWKPWJJP-UHFFFAOYSA-N 183255 US9150546, I-426::US9688643, I-426::US9718790, I-0425 P2X purinoceptor 3 Homo sapiens 211 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183255 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183255&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578584 313634655 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470652 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc3n(C)ccc3c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H26ClN5O4/c1-25(2,21(32)35-4)15-31-23(33)28-22(27-19-9-10-20-17(13-19)11-12-29(20)3)30(24(31)34)14-16-5-7-18(26)8-6-16/h5-13H,14-15H2,1-4H3,(H,27,28,33) XYQHDOWUQZVEED-UHFFFAOYSA-N 183256 BDBM265278::US9150546, I-427::US9688643, I-427 P2X purinoceptor 3 Homo sapiens 678 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183256 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183256&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578784 313634656 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470653 CC(C)(Cn1c(=O)[nH]\c(=N/c2ccc(O)c(Cl)c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O InChI=1S/C21H20Cl2N4O5/c1-21(2,17(29)30)11-27-19(31)25-18(24-14-7-8-16(28)15(23)9-14)26(20(27)32)10-12-3-5-13(22)6-4-12/h3-9,28H,10-11H2,1-2H3,(H,29,30)(H,24,25,31) GIRJLUJEDZDUPQ-UHFFFAOYSA-N 183257 US9150546, I-429::US9688643, I-429::US9718790, I-0428 P2X purinoceptor 3 Homo sapiens 779 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183257 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183257&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578463 313634657 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470654 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H31ClN4O5/c1-16(2)36-21-12-11-20(13-17(21)3)28-23-29-24(33)31(15-26(4,5)22(32)35-6)25(34)30(23)14-18-7-9-19(27)10-8-18/h7-13,16H,14-15H2,1-6H3,(H,28,29,33) HNEFEUVSRBUTDF-UHFFFAOYSA-N 183258 US9150546, I-431::US9688643, I-431::US9718790, I-0430 P2X purinoceptor 3 Homo sapiens 4.00 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183258 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183258&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578498 313634658 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470655 CC(C)Oc1ccc(cc1C)\N=c1/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C25H29ClN4O5/c1-15(2)35-20-11-10-19(12-16(20)3)27-22-28-23(33)30(14-25(4,5)21(31)32)24(34)29(22)13-17-6-8-18(26)9-7-17/h6-12,15H,13-14H2,1-5H3,(H,31,32)(H,27,28,33) QAOVRPBLQVFODI-UHFFFAOYSA-N 183259 US9150546, I-432::US9688643, I-432::US9718790, I-0431 P2X purinoceptor 3 Homo sapiens 26 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183259 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183259&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578521 313634659 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470656 COc1nc(=O)n(Cc2ccc(Cl)cc2)\c(=N\c2ccc(OC(C)C)c(Cl)c2)[nH]1 InChI=1S/C20H20Cl2N4O3/c1-12(2)29-17-9-8-15(10-16(17)22)23-18-24-19(28-3)25-20(27)26(18)11-13-4-6-14(21)7-5-13/h4-10,12H,11H2,1-3H3,(H,23,24,25,27) BLXHTNIMBSZEGS-UHFFFAOYSA-N 183260 US9150546, I-433::US9688643, I-433::US9718790, I-0432 P2X purinoceptor 3 Homo sapiens 199 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183260 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183260&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 119099066 313634660 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470657 CC(C)Oc1ccc(Nc2nc(OCCO)nc(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C21H22ClFN4O4/c1-13(2)31-18-8-7-16(11-17(18)23)24-19-25-20(30-10-9-28)26-21(29)27(19)12-14-3-5-15(22)6-4-14/h3-8,11,13,28H,9-10,12H2,1-2H3,(H,24,25,26,29) PHCRNZGGIOWYGF-UHFFFAOYSA-N 183261 US9150546, II-002::US9688643, II-002::US9718790, I-0434 P2X purinoceptor 3 Homo sapiens 79 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183261 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183261&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578797 313634661 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470658 CC(C)Oc1ccc(Nc2nc(OCCCO)nc(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C22H24ClFN4O4/c1-14(2)32-19-9-8-17(12-18(19)24)25-20-26-21(31-11-3-10-29)27-22(30)28(20)13-15-4-6-16(23)7-5-15/h4-9,12,14,29H,3,10-11,13H2,1-2H3,(H,25,26,27,30) CODUWDUTHTZBMI-UHFFFAOYSA-N 183262 US9150546, II-006::US9688643, II-006::US9718790, I-0438 P2X purinoceptor 3 Homo sapiens 398 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183262 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183262&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578709 313634662 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470659 CC(C)Oc1ccc(Nc2nc(OCC(CO)CO)nc(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C23H26ClFN4O5/c1-14(2)34-20-8-7-18(9-19(20)25)26-21-27-22(33-13-16(11-30)12-31)28-23(32)29(21)10-15-3-5-17(24)6-4-15/h3-9,14,16,30-31H,10-13H2,1-2H3,(H,26,27,28,32) LYDDBGQLQCSRHN-UHFFFAOYSA-N 183263 US9150546, II-008::US9688643, II-008::US9718790, I-0440 P2X purinoceptor 3 Homo sapiens 943 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183263 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183263&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578799 313634663 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470660 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(OCC(O)=O)nc(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C21H20Cl2N4O5/c1-12(2)32-17-8-7-15(9-16(17)23)24-19-25-20(31-11-18(28)29)26-21(30)27(19)10-13-3-5-14(22)6-4-13/h3-9,12H,10-11H2,1-2H3,(H,28,29)(H,24,25,26,30) AIQQRNKMARTPQG-UHFFFAOYSA-N 183264 US9150546, II-009::US9688643, II-009::US9718790, I-0441 P2X purinoceptor 3 Homo sapiens 34 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183264 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183264&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 119099067 313634664 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470661 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(OCC(C)(C)C(O)=O)nc(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C24H26Cl2N4O5/c1-14(2)35-19-10-9-17(11-18(19)26)27-21-28-22(34-13-24(3,4)20(31)32)29-23(33)30(21)12-15-5-7-16(25)8-6-15/h5-11,14H,12-13H2,1-4H3,(H,31,32)(H,27,28,29,33) JDUIQMJXOFCZDY-UHFFFAOYSA-N 183265 US9150546, II-010::US9688643, II-010::US9718790, I-0442 P2X purinoceptor 3 Homo sapiens 349 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183265 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183265&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 119099068 313634665 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470662 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(CC(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C21H20Cl2N4O5/c1-12(2)32-17-8-7-15(9-16(17)23)24-19-25-20(30)27(11-18(28)29)21(31)26(19)10-13-3-5-14(22)6-4-13/h3-9,12H,10-11H2,1-2H3,(H,28,29)(H,24,25,30) VEMXKDNCOMOECJ-UHFFFAOYSA-N 183266 US9150546, I-434::US9688643, I-434::US9718790, I-0443 P2X purinoceptor 3 Homo sapiens 407 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183266 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183266&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578367 313634666 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470663 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(CC(=O)NCC#N)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C23H22Cl2N6O4/c1-14(2)35-19-8-7-17(11-18(19)25)28-21-29-22(33)31(13-20(32)27-10-9-26)23(34)30(21)12-15-3-5-16(24)6-4-15/h3-8,11,14H,10,12-13H2,1-2H3,(H,27,32)(H,28,29,33) YIKMIGBCKDVAHZ-UHFFFAOYSA-N 183267 US9150546, I-435::US9688643, I-435::US9718790, I-0444 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183267 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183267&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 88558797 313634667 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470664 CNC(=O)Cn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(Cl)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C22H23Cl2N5O4/c1-13(2)33-18-9-8-16(10-17(18)24)26-20-27-21(31)29(12-19(30)25-3)22(32)28(20)11-14-4-6-15(23)7-5-14/h4-10,13H,11-12H2,1-3H3,(H,25,30)(H,26,27,31) MECLRPZHYAVFCN-UHFFFAOYSA-N 183268 US9150546, I-436::US9688643, I-436::US9718790, I-0445 P2X purinoceptor 3 Homo sapiens 8.00 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183268 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183268&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020149 313634668 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470665 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(CC(=O)NCCO)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C23H25Cl2N5O5/c1-14(2)35-19-8-7-17(11-18(19)25)27-21-28-22(33)30(13-20(32)26-9-10-31)23(34)29(21)12-15-3-5-16(24)6-4-15/h3-8,11,14,31H,9-10,12-13H2,1-2H3,(H,26,32)(H,27,28,33) BIYJLHSGOGOXOH-UHFFFAOYSA-N 183269 US9150546, I-437::US9688643, I-437::US9718790, I-0446 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183269 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183269&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020741 313634669 C04080 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470666 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(CC(=O)NCC(N)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C23H24Cl2N6O5/c1-13(2)36-18-8-7-16(9-17(18)25)28-21-29-22(34)31(12-20(33)27-10-19(26)32)23(35)30(21)11-14-3-5-15(24)6-4-14/h3-9,13H,10-12H2,1-2H3,(H2,26,32)(H,27,33)(H,28,29,34) PYMAUQBCJZWXQE-UHFFFAOYSA-N 183270 US9150546, I-438::US9688643, I-438::US9718790, I-0447 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183270 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183270&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020742 313634670 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470667 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n(CCC(=O)NCC#N)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C24H24ClFN6O4/c1-15(2)36-20-8-7-18(13-19(20)26)29-22-30-23(34)31(12-9-21(33)28-11-10-27)24(35)32(22)14-16-3-5-17(25)6-4-16/h3-8,13,15H,9,11-12,14H2,1-2H3,(H,28,33)(H,29,30,34) KKWDEJBVLDOLBA-UHFFFAOYSA-N 183271 US9150546, I-439::US9688643, I-439::US9718790, I-0448 P2X purinoceptor 3 Homo sapiens 18 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183271 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183271&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578770 313634671 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470668 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n(CCC(=O)NCC(N)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C24H26ClFN6O5/c1-14(2)37-19-8-7-17(11-18(19)26)29-22-30-23(35)31(10-9-21(34)28-12-20(27)33)24(36)32(22)13-15-3-5-16(25)6-4-15/h3-8,11,14H,9-10,12-13H2,1-2H3,(H2,27,33)(H,28,34)(H,29,30,35) RGZKSIUPCLTSCH-UHFFFAOYSA-N 183272 US9150546, I-440::US9688643, I-440::US9718790, I-0449 P2X purinoceptor 3 Homo sapiens 55 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183272 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183272&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578555 313634672 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470669 CCOc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(CC(C)(C)C(=O)OC)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C24H26Cl2N4O5/c1-5-35-19-11-10-17(12-18(19)26)27-21-28-22(32)30(14-24(2,3)20(31)34-4)23(33)29(21)13-15-6-8-16(25)9-7-15/h6-12H,5,13-14H2,1-4H3,(H,27,28,32) DWLNSOSNBWRGBL-UHFFFAOYSA-N 183273 US9150546, I-441::US9688643, I-441::US9718790, I-0450 P2X purinoceptor 3 Homo sapiens 11 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183273 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183273&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578550 313634673 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470670 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(OC)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H27ClN4O5/c1-15-12-18(10-11-19(15)33-4)26-21-27-22(31)29(14-24(2,3)20(30)34-5)23(32)28(21)13-16-6-8-17(25)9-7-16/h6-12H,13-14H2,1-5H3,(H,26,27,31) XOWYLKBNXGGNSB-UHFFFAOYSA-N 183274 US9150546, I-442::US9688643, I-442::US9718790, I-0451 P2X purinoceptor 3 Homo sapiens 117 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183274 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183274&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578703 313634674 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470671 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2cccc(OC(F)F)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H23ClF2N4O5/c1-23(2,18(31)34-3)13-30-21(32)28-20(27-16-5-4-6-17(11-16)35-19(25)26)29(22(30)33)12-14-7-9-15(24)10-8-14/h4-11,19H,12-13H2,1-3H3,(H,27,28,32) HFCDVAYEMKHXOT-UHFFFAOYSA-N 183275 US9150546, I-443::US9688643, I-443::US9718790, I-0452 P2X purinoceptor 3 Homo sapiens 207 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183275 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183275&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578778 313634675 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470672 COC(=O)c1ccc(Cn2c(=O)[nH]\c(=N/c3ccc(OC(C)C)c(F)c3)n(Cc3ccc(Cl)cc3)c2=O)cc1 InChI=1S/C28H26ClFN4O5/c1-17(2)39-24-13-12-22(14-23(24)30)31-26-32-27(36)34(16-18-4-8-20(9-5-18)25(35)38-3)28(37)33(26)15-19-6-10-21(29)11-7-19/h4-14,17H,15-16H2,1-3H3,(H,31,32,36) ZHMRJAFBBUPXMN-UHFFFAOYSA-N 183276 US9150546, I-444::US9688643, I-444::US9718790, I-0453 P2X purinoceptor 3 Homo sapiens 17 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183276 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183276&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578403 313634676 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470673 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n(Cc2ccc(cc2)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C27H24ClFN4O5/c1-16(2)38-23-12-11-21(13-22(23)29)30-25-31-26(36)33(15-17-3-7-19(8-4-17)24(34)35)27(37)32(25)14-18-5-9-20(28)10-6-18/h3-13,16H,14-15H2,1-2H3,(H,34,35)(H,30,31,36) DNJOLFSVJHMOER-UHFFFAOYSA-N 183277 US9150546, I-445::US9688643, I-445::US9718790, I-0454 P2X purinoceptor 3 Homo sapiens 8.00 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183277 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183277&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578446 313634677 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470674 CCOc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C23H24Cl2N4O5/c1-4-34-18-10-9-16(11-17(18)25)26-20-27-21(32)29(13-23(2,3)19(30)31)22(33)28(20)12-14-5-7-15(24)8-6-14/h5-11H,4,12-13H2,1-3H3,(H,30,31)(H,26,27,32) PYUFNUBNBBFONC-UHFFFAOYSA-N 183278 US9150546, I-446::US9688643, I-446::US9718790, I-0455 P2X purinoceptor 3 Homo sapiens 20 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183278 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183278&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578767 313634678 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470675 COc1ccc(cc1C)\N=c1/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C23H25ClN4O5/c1-14-11-17(9-10-18(14)33-4)25-20-26-21(31)28(13-23(2,3)19(29)30)22(32)27(20)12-15-5-7-16(24)8-6-15/h5-11H,12-13H2,1-4H3,(H,29,30)(H,25,26,31) NWLNPCNCHXEXRK-UHFFFAOYSA-N 183279 US9150546, I-447::US9688643, I-447::US9718790, I-0456 P2X purinoceptor 3 Homo sapiens 279 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183279 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183279&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578879 313634679 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470676 CC(C)(Cn1c(=O)[nH]\c(=N/c2cccc(OC(F)F)c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O InChI=1S/C22H21ClF2N4O5/c1-22(2,17(30)31)12-29-20(32)27-19(26-15-4-3-5-16(10-15)34-18(24)25)28(21(29)33)11-13-6-8-14(23)9-7-13/h3-10,18H,11-12H2,1-2H3,(H,30,31)(H,26,27,32) OUDZDPSOGUVUGK-UHFFFAOYSA-N 183280 US9150546, I-448::US9688643, I-448::US9718790, I-0457 P2X purinoceptor 3 Homo sapiens 388 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183280 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183280&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578657 313634680 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470677 COC(=O)c1cccc(Cn2c(=O)[nH]\c(=N/c3ccc(OC(C)C)c(F)c3)n(Cc3ccc(Cl)cc3)c2=O)c1 InChI=1S/C28H26ClFN4O5/c1-17(2)39-24-12-11-22(14-23(24)30)31-26-32-27(36)34(16-19-5-4-6-20(13-19)25(35)38-3)28(37)33(26)15-18-7-9-21(29)10-8-18/h4-14,17H,15-16H2,1-3H3,(H,31,32,36) HLAKNNMHJAMFON-UHFFFAOYSA-N 183281 US9150546, I-450::US9688643, I-450::US9718790, I-0459 P2X purinoceptor 3 Homo sapiens 36 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183281 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183281&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578760 313634681 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470678 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n(Cc2cccc(c2)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C27H24ClFN4O5/c1-16(2)38-23-11-10-21(13-22(23)29)30-25-31-26(36)33(15-18-4-3-5-19(12-18)24(34)35)27(37)32(25)14-17-6-8-20(28)9-7-17/h3-13,16H,14-15H2,1-2H3,(H,34,35)(H,30,31,36) KRVHHMRULNJILW-UHFFFAOYSA-N 183282 US9150546, I-451::US9688643, I-451::US9718790, I-0460 P2X purinoceptor 3 Homo sapiens 16 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183282 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183282&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578505 313634682 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470679 COC(=O)[C@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O 183283 US9150546, I-452::US9688643, I-452::US9718790, I-0461 P2X purinoceptor 3 Homo sapiens 3.00 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183283 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183283&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578451 313634683 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470680 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O 183284 US9150546, I-453::US9688643, I-453::US9718790, I-0462 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183284 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183284&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578468 313634684 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470681 CCOC(=O)c1ccccc1Cn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C29H28ClFN4O5/c1-4-39-26(36)23-8-6-5-7-20(23)17-35-28(37)33-27(32-22-13-14-25(24(31)15-22)40-18(2)3)34(29(35)38)16-19-9-11-21(30)12-10-19/h5-15,18H,4,16-17H2,1-3H3,(H,32,33,37) OBBYQKMKICRPKD-UHFFFAOYSA-N 183285 US9150546, I-454::US9688643, I-454::US9718790, I-0463 P2X purinoceptor 3 Homo sapiens 24 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183285 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183285&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578850 313634685 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470682 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n(C[C@@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 183286 US9150546, I-455::US9688643, I-455::US9718790, I-0464 P2X purinoceptor 3 Homo sapiens 30 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183286 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183286&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578375 313634686 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470683 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 183287 US9150546, I-456::US9688643, I-456::US9718790, I-0465 P2X purinoceptor 3 Homo sapiens 8.00 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183287 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183287&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578933 313634687 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470684 COC(=O)[C@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(Cl)c2)n(Cc2ccc(Cl)cc2)c1=O 183288 US9150546, I-457::US9688643, I-457::US9718790, I-0466 P2X purinoceptor 3 Homo sapiens 3.00 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183288 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183288&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578609 313634688 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470685 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(Cl)c2)n(Cc2ccc(Cl)cc2)c1=O 183289 US9150546, I-458::US9688643, I-458::US9718790, I-0467 P2X purinoceptor 3 Homo sapiens 4.00 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183289 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183289&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578838 313634689 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470686 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n(Cc2ccccc2C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C27H24ClFN4O5/c1-16(2)38-23-12-11-20(13-22(23)29)30-25-31-26(36)33(15-18-5-3-4-6-21(18)24(34)35)27(37)32(25)14-17-7-9-19(28)10-8-17/h3-13,16H,14-15H2,1-2H3,(H,34,35)(H,30,31,36) DVUTVMVNMJUMHZ-UHFFFAOYSA-N 183290 US9150546, I-459::US9688643, I-459::US9718790, I-0468 P2X purinoceptor 3 Homo sapiens 39 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183290 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183290&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578785 313634690 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470687 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(C[C@@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 183291 US9150546, I-460::US9688643, I-460::US9718790, I-0469 P2X purinoceptor 3 Homo sapiens 16 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183291 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183291&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578529 313634691 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470688 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 183292 US9150546, I-461::US9688643, I-461::US9718790, I-0470 P2X purinoceptor 3 Homo sapiens 9.00 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183292 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183292&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578746 313634692 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470689 CCOc1ccc(cc1C)\N=c1/[nH]c(=O)n(CC(C)(C)C(=O)OC)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C25H29ClN4O5/c1-6-35-20-12-11-19(13-16(20)2)27-22-28-23(32)30(15-25(3,4)21(31)34-5)24(33)29(22)14-17-7-9-18(26)10-8-17/h7-13H,6,14-15H2,1-5H3,(H,27,28,32) JQRLNIOYJHNYAQ-UHFFFAOYSA-N 183293 US9150546, I-462::US9688643, I-462::US9718790, I-0471 P2X purinoceptor 3 Homo sapiens 4.00 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183293 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183293&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578456 313634693 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470690 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(C)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H27ClN4O4/c1-15-6-11-19(12-16(15)2)26-21-27-22(31)29(14-24(3,4)20(30)33-5)23(32)28(21)13-17-7-9-18(25)10-8-17/h6-12H,13-14H2,1-5H3,(H,26,27,31) LCTXMEPCVOFRSI-UHFFFAOYSA-N 183294 US9150546, I-463::US9688643, I-463::US9718790, I-0472 P2X purinoceptor 3 Homo sapiens 74 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183294 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183294&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578368 313634694 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470691 Cc1ccc(cc1C)\N=c1/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C23H25ClN4O4/c1-14-5-10-18(11-15(14)2)25-20-26-21(31)28(13-23(3,4)19(29)30)22(32)27(20)12-16-6-8-17(24)9-7-16/h5-11H,12-13H2,1-4H3,(H,29,30)(H,25,26,31) VETDRJDGGSYGGI-UHFFFAOYSA-N 183295 US9150546, I-464::US9688643, I-464::US9718790, I-0473 P2X purinoceptor 3 Homo sapiens 564 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183295 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183295&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578487 313634695 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470692 CCOc1ccc(cc1C)\N=c1/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C24H27ClN4O5/c1-5-34-19-11-10-18(12-15(19)2)26-21-27-22(32)29(14-24(3,4)20(30)31)23(33)28(21)13-16-6-8-17(25)9-7-16/h6-12H,5,13-14H2,1-4H3,(H,30,31)(H,26,27,32) UAGYKUJNNDRACK-UHFFFAOYSA-N 183296 US9150546, I-465::US9688643, I-465::US9718790, I-0474 P2X purinoceptor 3 Homo sapiens 57 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183296 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183296&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578552 313634696 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470693 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2cccc(Cl)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C22H22Cl2N4O4/c1-22(2,18(29)32-3)13-28-20(30)26-19(25-17-6-4-5-16(24)11-17)27(21(28)31)12-14-7-9-15(23)10-8-14/h4-11H,12-13H2,1-3H3,(H,25,26,30) BGADQIBSLMMIBV-UHFFFAOYSA-N 183297 US9150546, I-466::US9688643, I-466::US9718790, I-0475 P2X purinoceptor 3 Homo sapiens 37 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183297 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183297&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578386 313634697 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470694 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2cccc(OC(F)(F)F)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H22ClF3N4O5/c1-22(2,18(32)35-3)13-31-20(33)29-19(28-16-5-4-6-17(11-16)36-23(25,26)27)30(21(31)34)12-14-7-9-15(24)10-8-14/h4-11H,12-13H2,1-3H3,(H,28,29,33) SPZRXZLQIWQTDM-UHFFFAOYSA-N 183298 US9150546, I-467::US9688643, I-467::US9718790, I-0476 P2X purinoceptor 3 Homo sapiens 37 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183298 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183298&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578889 313634698 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470695 CC(C)(Cn1c(=O)[nH]\c(=N/c2cccc(Cl)c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O InChI=1S/C21H20Cl2N4O4/c1-21(2,17(28)29)12-27-19(30)25-18(24-16-5-3-4-15(23)10-16)26(20(27)31)11-13-6-8-14(22)9-7-13/h3-10H,11-12H2,1-2H3,(H,28,29)(H,24,25,30) VRQZGCHSOQRPQF-UHFFFAOYSA-N 183299 US9150546, I-468::US9688643, I-468::US9718790, I-0477 P2X purinoceptor 3 Homo sapiens 137 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183299 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183299&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578413 313634699 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470696 CC(C)(Cn1c(=O)[nH]\c(=N/c2cccc(OC(F)(F)F)c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O InChI=1S/C22H20ClF3N4O5/c1-21(2,17(31)32)12-30-19(33)28-18(27-15-4-3-5-16(10-15)35-22(24,25)26)29(20(30)34)11-13-6-8-14(23)9-7-13/h3-10H,11-12H2,1-2H3,(H,31,32)(H,27,28,33) OFBGTHRBXJQAKW-UHFFFAOYSA-N 183300 US9150546, I-469::US9688643, I-469::US9718790, I-0478 P2X purinoceptor 3 Homo sapiens 101 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183300 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183300&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578601 313634700 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470697 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc3[nH]ccc3c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H24ClN5O4/c1-24(2,20(31)34-3)14-30-22(32)28-21(27-18-8-9-19-16(12-18)10-11-26-19)29(23(30)33)13-15-4-6-17(25)7-5-15/h4-12,26H,13-14H2,1-3H3,(H,27,28,32) QUUJAAQFGPTNJB-UHFFFAOYSA-N 183301 US9150546, I-470::US9688643, I-470::US9718790, I-0479 P2X purinoceptor 3 Homo sapiens 80 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183301 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183301&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578909 313634701 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470698 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2cccc(c2)C(F)(F)F)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H22ClF3N4O4/c1-22(2,18(32)35-3)13-31-20(33)29-19(28-17-6-4-5-15(11-17)23(25,26)27)30(21(31)34)12-14-7-9-16(24)10-8-14/h4-11H,12-13H2,1-3H3,(H,28,29,33) RKIAQDSYNKVHJJ-UHFFFAOYSA-N 183302 US9150546, I-471::US9688643, I-471::US9718790, I-0480 P2X purinoceptor 3 Homo sapiens 24 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183302 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183302&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578429 313634702 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470699 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(Cl)c(Cl)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C22H21Cl3N4O4/c1-22(2,18(30)33-3)12-29-20(31)27-19(26-15-8-9-16(24)17(25)10-15)28(21(29)32)11-13-4-6-14(23)7-5-13/h4-10H,11-12H2,1-3H3,(H,26,27,31) RDLMYGPENFGHLI-UHFFFAOYSA-N 183303 US9150546, I-472::US9688643, I-472::US9718790, I-0481 P2X purinoceptor 3 Homo sapiens 47 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183303 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183303&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578666 313634703 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470700 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)nc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H28ClN5O5/c1-15(2)35-19-11-10-18(12-26-19)27-21-28-22(32)30(14-24(3,4)20(31)34-5)23(33)29(21)13-16-6-8-17(25)9-7-16/h6-12,15H,13-14H2,1-5H3,(H,27,28,32) BSTAKLZFGBHMOK-UHFFFAOYSA-N 183304 US9150546, I-473::US9688643, I-473::US9718790, I-0482 P2X purinoceptor 3 Homo sapiens 583 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183304 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183304&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578441 313634704 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470701 COC(=O)C(C)n1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O 183305 US9150546, I-474::US9688643, I-474::US9718790, I-0483 P2X purinoceptor 3 Homo sapiens 14 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183305 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183305&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578472 313634705 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470702 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n(C(C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 183306 US9150546, I-475::US9688643, I-475::US9718790, I-0484 P2X purinoceptor 3 Homo sapiens 571 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183306 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183306&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578660 313634706 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470703 CC(C)(Cn1c(=O)[nH]\c(=N/c2cccc(c2)C(F)(F)F)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O InChI=1S/C22H20ClF3N4O4/c1-21(2,17(31)32)12-30-19(33)28-18(27-16-5-3-4-14(10-16)22(24,25)26)29(20(30)34)11-13-6-8-15(23)9-7-13/h3-10H,11-12H2,1-2H3,(H,31,32)(H,27,28,33) GWKWQVXRPIJDAM-UHFFFAOYSA-N 183307 US9150546, I-476::US9688643, I-476::US9718790, I-0485 P2X purinoceptor 3 Homo sapiens 35 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183307 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183307&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578436 313634707 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470704 CC(C)(Cn1c(=O)[nH]\c(=N/c2ccc(Cl)c(Cl)c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O InChI=1S/C21H19Cl3N4O4/c1-21(2,17(29)30)11-28-19(31)26-18(25-14-7-8-15(23)16(24)9-14)27(20(28)32)10-12-3-5-13(22)6-4-12/h3-9H,10-11H2,1-2H3,(H,29,30)(H,25,26,31) VMTZHIZQTJWQIE-UHFFFAOYSA-N 183308 US9150546, I-477::US9688643, I-477::US9718790, I-0486 P2X purinoceptor 3 Homo sapiens 56 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183308 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183308&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578604 313634708 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470705 CC(C)(Cn1c(=O)[nH]\c(=N/c2ccc3[nH]ccc3c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O InChI=1S/C23H22ClN5O4/c1-23(2,19(30)31)13-29-21(32)27-20(26-17-7-8-18-15(11-17)9-10-25-18)28(22(29)33)12-14-3-5-16(24)6-4-14/h3-11,25H,12-13H2,1-2H3,(H,30,31)(H,26,27,32) CISPGXOHZZTVHA-UHFFFAOYSA-N 183309 US9150546, I-478::US9688643, I-478::US9718790, I-0487 P2X purinoceptor 3 Homo sapiens 629 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183309 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183309&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578908 313634709 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470706 COC(=O)[C@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)cc2)n(Cc2ccc(Cl)cc2)c1=O 183310 US9150546, I-479::US9688643, I-479::US9718790, I-0488 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183310 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183310&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578589 313634710 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470707 CCOc1ccc(cc1)\N=c1/[nH]c(=O)n(C[C@@H](C)C(=O)OC)c(=O)n1Cc1ccc(Cl)cc1 183311 US9150546, I-480::US9688643, I-480::US9718790, I-0489 P2X purinoceptor 3 Homo sapiens 12 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183311 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183311&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578937 313634711 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470708 CCOc1ccc(cc1C)\N=c1/[nH]c(=O)n(C[C@@H](C)C(=O)OC)c(=O)n1Cc1ccc(Cl)cc1 183312 US9150546, I-481::US9688643, I-481::US9718790, I-0490 P2X purinoceptor 3 Homo sapiens 12 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183312 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183312&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578417 313634712 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470709 CC(C)Oc1ccc(cc1)\N=c1/[nH]c(=O)n(C[C@@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 183313 US9150546, I-483::US9688643, I-483::US9718790, I-0492 P2X purinoceptor 3 Homo sapiens 100 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183313 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183313&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578892 313634713 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470710 CCOc1ccc(cc1)\N=c1/[nH]c(=O)n(C[C@@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 183314 US9150546, I-484::US9688643, I-484::US9718790, I-0493 P2X purinoceptor 3 Homo sapiens 290 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183314 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183314&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578830 313634714 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470711 CCOc1ccc(cc1C)\N=c1/[nH]c(=O)n(C[C@@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 183315 US9150546, I-485::US9688643, I-485::US9718790, I-0494 P2X purinoceptor 3 Homo sapiens 198 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183315 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183315&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578794 313634715 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470712 CC(C)Oc1ccc(cc1C)\N=c1/[nH]c(=O)n(C[C@@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 183316 US9150546, I-486::US9688643, I-486::US9718790, I-0495 P2X purinoceptor 3 Homo sapiens 42 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183316 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183316&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578773 313634716 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470713 CCOc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(C[C@@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 183317 US9150546, I-487::US9688643, I-487::US9718790, I-0496 P2X purinoceptor 3 Homo sapiens 27 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183317 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183317&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578939 313634717 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470714 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc3oc(C)nc3c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H24ClN5O5/c1-14-26-18-11-17(9-10-19(18)35-14)27-21-28-22(32)30(13-24(2,3)20(31)34-4)23(33)29(21)12-15-5-7-16(25)8-6-15/h5-11H,12-13H2,1-4H3,(H,27,28,32) BWWMLEAJMQPMGW-UHFFFAOYSA-N 183318 US9150546, I-488::US9688643, I-488::US9718790, I-0497 P2X purinoceptor 3 Homo sapiens 124 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183318 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183318&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578565 313634718 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470715 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc3oc(C)cc3c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H25ClN4O5/c1-15-11-17-12-19(9-10-20(17)35-15)27-22-28-23(32)30(14-25(2,3)21(31)34-4)24(33)29(22)13-16-5-7-18(26)8-6-16/h5-12H,13-14H2,1-4H3,(H,27,28,32) GYFNLPAGZFKNSP-UHFFFAOYSA-N 183319 US9150546, I-489::US9688643, I-489::US9718790, I-0498 P2X purinoceptor 3 Homo sapiens 10.00 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183319 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183319&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578659 313634719 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470716 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(CN(C)C)c(Cl)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H29Cl2N5O4/c1-25(2,21(33)36-5)15-32-23(34)29-22(28-19-11-8-17(14-30(3)4)20(27)12-19)31(24(32)35)13-16-6-9-18(26)10-7-16/h6-12H,13-15H2,1-5H3,(H,28,29,34) XHHFQYQVSXWJKI-UHFFFAOYSA-N 183320 US9150546, I-490::US9688643, I-490::US9718790, I-0499 P2X purinoceptor 3 Homo sapiens 46 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183320 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183320&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578600 313634720 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470717 Cc1cc2cc(ccc2o1)\N=c1/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C24H23ClN4O5/c1-14-10-16-11-18(8-9-19(16)34-14)26-21-27-22(32)29(13-24(2,3)20(30)31)23(33)28(21)12-15-4-6-17(25)7-5-15/h4-11H,12-13H2,1-3H3,(H,30,31)(H,26,27,32) BDZSWGJDARTUHN-UHFFFAOYSA-N 183321 US9150546, I-491::US9688643, I-491::US9718790, I-0500 P2X purinoceptor 3 Homo sapiens 27 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183321 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183321&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578954 313634721 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470718 CCn1ccc2cc(ccc12)\N=c1/[nH]c(=O)n(CC(C)(C)C(=O)OC)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C26H28ClN5O4/c1-5-30-13-12-18-14-20(10-11-21(18)30)28-23-29-24(34)32(16-26(2,3)22(33)36-4)25(35)31(23)15-17-6-8-19(27)9-7-17/h6-14H,5,15-16H2,1-4H3,(H,28,29,34) YGKBHZHTBZHKRV-UHFFFAOYSA-N 183322 US9150546, I-492::US9688643, I-492::US9718790, I-0501 P2X purinoceptor 3 Homo sapiens 102 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183322 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183322&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578940 313634722 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470719 CCn1ccc2cc(ccc12)\N=c1/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C25H26ClN5O4/c1-4-29-12-11-17-13-19(9-10-20(17)29)27-22-28-23(34)31(15-25(2,3)21(32)33)24(35)30(22)14-16-5-7-18(26)8-6-16/h5-13H,4,14-15H2,1-3H3,(H,32,33)(H,27,28,34) JOBNQHGVFFAIKQ-UHFFFAOYSA-N 183323 US9150546, I-493::US9688643, I-493::US9718790, I-0502 P2X purinoceptor 3 Homo sapiens 952 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183323 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183323&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578622 313634723 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470720 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc3nc(C)oc3c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H24ClN5O5/c1-14-26-18-10-9-17(11-19(18)35-14)27-21-28-22(32)30(13-24(2,3)20(31)34-4)23(33)29(21)12-15-5-7-16(25)8-6-15/h5-11H,12-13H2,1-4H3,(H,27,28,32) DERUTLWVSXYUBL-UHFFFAOYSA-N 183324 US9150546, I-494::US9688643, I-494::US9718790, I-0503 P2X purinoceptor 3 Homo sapiens 34 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183324 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183324&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578858 313634724 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470721 CN(C)Cc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C24H27Cl2N5O4/c1-24(2,20(32)33)14-31-22(34)28-21(27-18-10-7-16(13-29(3)4)19(26)11-18)30(23(31)35)12-15-5-8-17(25)9-6-15/h5-11H,12-14H2,1-4H3,(H,32,33)(H,27,28,34) CQRVXUVYPUKGAY-UHFFFAOYSA-N 183325 US9150546, I-495::US9688643, I-495::US9718790, I-0504 P2X purinoceptor 3 Homo sapiens 125 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183325 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183325&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578874 313634725 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470722 Cc1nc2ccc(cc2o1)\N=c1/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C23H22ClN5O5/c1-13-25-17-9-8-16(10-18(17)34-13)26-20-27-21(32)29(12-23(2,3)19(30)31)22(33)28(20)11-14-4-6-15(24)7-5-14/h4-10H,11-12H2,1-3H3,(H,30,31)(H,26,27,32) MDIBYOPAIJSTAN-UHFFFAOYSA-N 183326 US9150546, I-496::US9688643, I-496::US9718790, I-0505 P2X purinoceptor 3 Homo sapiens 125 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183326 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183326&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578848 313634726 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470723 Cc1nc2cc(ccc2o1)\N=c1/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C23H22ClN5O5/c1-13-25-17-10-16(8-9-18(17)34-13)26-20-27-21(32)29(12-23(2,3)19(30)31)22(33)28(20)11-14-4-6-15(24)7-5-14/h4-10H,11-12H2,1-3H3,(H,30,31)(H,26,27,32) QXSSRYCKGNMWJG-UHFFFAOYSA-N 183327 US9150546, I-497::US9688643, I-497::US9718790, I-0506 P2X purinoceptor 3 Homo sapiens 458 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183327 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183327&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578615 313634727 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470724 CCOC(=O)CCCn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(Cl)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H28Cl2N4O5/c1-4-35-22(32)6-5-13-30-24(33)29-23(28-19-11-12-21(20(27)14-19)36-16(2)3)31(25(30)34)15-17-7-9-18(26)10-8-17/h7-12,14,16H,4-6,13,15H2,1-3H3,(H,28,29,33) RZCZZXLNXHRKPV-UHFFFAOYSA-N 183328 US9150546, I-498::US9688643, I-498::US9718790, I-0507 P2X purinoceptor 3 Homo sapiens 9.00 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183328 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183328&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578625 313634728 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470725 CC(C)Oc1ccc(cc1C)\N=c1/[nH]c(=O)[nH]c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C20H21ClN4O3/c1-12(2)28-17-9-8-16(10-13(17)3)22-18-23-19(26)24-20(27)25(18)11-14-4-6-15(21)7-5-14/h4-10,12H,11H2,1-3H3,(H2,22,23,24,26,27) BISBPWAYYOPSQX-UHFFFAOYSA-N 183329 US9150546, I-499::US9688643, I-499::US9718790, I-0508 P2X purinoceptor 3 Homo sapiens 137 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183329 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183329&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578699 313634729 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470726 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(CCCC(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C23H24Cl2N4O5/c1-14(2)34-19-10-9-17(12-18(19)25)26-21-27-22(32)28(11-3-4-20(30)31)23(33)29(21)13-15-5-7-16(24)8-6-15/h5-10,12,14H,3-4,11,13H2,1-2H3,(H,30,31)(H,26,27,32) WCZMIXQUMLQDCK-UHFFFAOYSA-N 183330 US9150546, I-500::US9688643, I-500::US9718790, I-0509 P2X purinoceptor 3 Homo sapiens 13 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183330 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183330&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578791 313634730 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470727 Cc1cc2cc(ccc2o1)\N=c1/[nH]c(=O)[nH]c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C19H15ClN4O3/c1-11-8-13-9-15(6-7-16(13)27-11)21-17-22-18(25)23-19(26)24(17)10-12-2-4-14(20)5-3-12/h2-9H,10H2,1H3,(H2,21,22,23,25,26) LINZAOUDZMSNFJ-UHFFFAOYSA-N 183331 US9150546, I-501::US9688643, I-501::US9718790, I-0510 P2X purinoceptor 3 Homo sapiens 191 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183331 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183331&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578605 313634731 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470728 CCOC(=O)CCCn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H31ClN4O5/c1-5-35-23(32)7-6-14-30-25(33)29-24(28-21-12-13-22(18(4)15-21)36-17(2)3)31(26(30)34)16-19-8-10-20(27)11-9-19/h8-13,15,17H,5-7,14,16H2,1-4H3,(H,28,29,33) CHEHAKBBCUEQJD-UHFFFAOYSA-N 183332 US9150546, I-502::US9688643, I-502::US9718790, I-0511 P2X purinoceptor 3 Homo sapiens 20 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183332 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183332&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578821 313634732 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470729 CC(C)Oc1ccc(cc1C)\N=c1/[nH]c(=O)n(CCCC(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C24H27ClN4O5/c1-15(2)34-20-11-10-19(13-16(20)3)26-22-27-23(32)28(12-4-5-21(30)31)24(33)29(22)14-17-6-8-18(25)9-7-17/h6-11,13,15H,4-5,12,14H2,1-3H3,(H,30,31)(H,26,27,32) BXLWUDHFHPTRAG-UHFFFAOYSA-N 183333 US9150546, I-503::US9688643, I-503::US9718790, I-0512 P2X purinoceptor 3 Homo sapiens 50 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183333 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183333&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578619 313634733 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470730 CCOC(=O)CCCn1c(=O)[nH]\c(=N/c2ccc3oc(C)cc3c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H25ClN4O5/c1-3-34-22(31)5-4-12-29-24(32)28-23(27-20-10-11-21-18(14-20)13-16(2)35-21)30(25(29)33)15-17-6-8-19(26)9-7-17/h6-11,13-14H,3-5,12,15H2,1-2H3,(H,27,28,32) NRMCIFMJBUNITC-UHFFFAOYSA-N 183334 US9150546, I-504::US9688643, I-504::US9718790, I-0513 P2X purinoceptor 3 Homo sapiens 15 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183334 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183334&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578890 313634734 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470731 Cc1cc2cc(ccc2o1)\N=c1/[nH]c(=O)n(CCCC(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C23H21ClN4O5/c1-14-11-16-12-18(8-9-19(16)33-14)25-21-26-22(31)27(10-2-3-20(29)30)23(32)28(21)13-15-4-6-17(24)7-5-15/h4-9,11-12H,2-3,10,13H2,1H3,(H,29,30)(H,25,26,31) SPZUYZIZNIODLC-UHFFFAOYSA-N 183335 US9150546, I-505::US9688643, I-505::US9718790, I-0514 P2X purinoceptor 3 Homo sapiens 120 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183335 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183335&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578831 313634735 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470732 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc3n(CC(C)C)ccc3c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C28H32ClN5O4/c1-18(2)15-32-13-12-20-14-22(10-11-23(20)32)30-25-31-26(36)34(17-28(3,4)24(35)38-5)27(37)33(25)16-19-6-8-21(29)9-7-19/h6-14,18H,15-17H2,1-5H3,(H,30,31,36) YVYTXXAKCRMLAS-UHFFFAOYSA-N 183336 US9150546, I-506::US9688643, I-506::US9718790, I-0515 P2X purinoceptor 3 Homo sapiens 279 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183336 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183336&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578514 313634736 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470733 CCCn1ccc2cc(ccc12)\N=c1/[nH]c(=O)n(CC(C)(C)C(=O)OC)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C27H30ClN5O4/c1-5-13-31-14-12-19-15-21(10-11-22(19)31)29-24-30-25(35)33(17-27(2,3)23(34)37-4)26(36)32(24)16-18-6-8-20(28)9-7-18/h6-12,14-15H,5,13,16-17H2,1-4H3,(H,29,30,35) CZJPRYZTVINBPE-UHFFFAOYSA-N 183337 US9150546, I-507::US9688643, I-507::US9718790, I-0516 P2X purinoceptor 3 Homo sapiens 301 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183337 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183337&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578496 313634737 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470734 CC(C)Cn1ccc2cc(ccc12)\N=c1/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C27H30ClN5O4/c1-17(2)14-31-12-11-19-13-21(9-10-22(19)31)29-24-30-25(36)33(16-27(3,4)23(34)35)26(37)32(24)15-18-5-7-20(28)8-6-18/h5-13,17H,14-16H2,1-4H3,(H,34,35)(H,29,30,36) LSTHKOYNWJFZGC-UHFFFAOYSA-N 183338 US9150546, I-508::US9688643, I-508::US9718790, I-0517 P2X purinoceptor 3 Homo sapiens 511 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183338 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183338&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578383 313634738 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470735 CCCn1ccc2cc(ccc12)\N=c1/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C26H28ClN5O4/c1-4-12-30-13-11-18-14-20(9-10-21(18)30)28-23-29-24(35)32(16-26(2,3)22(33)34)25(36)31(23)15-17-5-7-19(27)8-6-17/h5-11,13-14H,4,12,15-16H2,1-3H3,(H,33,34)(H,28,29,35) OWGZMAZZYUSLCJ-UHFFFAOYSA-N 183339 US9150546, I-509::US9688643, I-509::US9718790, I-0518 P2X purinoceptor 3 Homo sapiens 652 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183339 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183339&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578485 313634739 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470736 CSc1cccc(c1)\N=c1/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C22H23ClN4O4S/c1-22(2,18(28)29)13-27-20(30)25-19(24-16-5-4-6-17(11-16)32-3)26(21(27)31)12-14-7-9-15(23)10-8-14/h4-11H,12-13H2,1-3H3,(H,28,29)(H,24,25,30) DQUCQFHPLJOMDY-UHFFFAOYSA-N 183340 US9150546, I-510::US9688643, I-510::US9718790, I-0519 P2X purinoceptor 3 Homo sapiens 98 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183340 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183340&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578919 313634740 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470737 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(F)c2)n(Cc2ccc(C)cc2)c1=O 183341 US9150546, I-515::US9688643, I-515::US9718790, I-0524 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183341 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183341&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578641 313634741 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470738 CCOC(=O)CCCn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(Cl)c2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C26H31ClN4O5/c1-5-35-23(32)7-6-14-30-25(33)29-24(28-20-12-13-22(21(27)15-20)36-17(2)3)31(26(30)34)16-19-10-8-18(4)9-11-19/h8-13,15,17H,5-7,14,16H2,1-4H3,(H,28,29,33) SGZWRROGODEEEX-UHFFFAOYSA-N 183342 US9150546, I-516::US9688643, I-516::US9718790, I-0525 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183342 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183342&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578724 313634742 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470739 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(C)cc1 183343 US9150546, I-517::US9688643, I-517::US9718790, I-0526 P2X purinoceptor 3 Homo sapiens 15 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183343 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183343&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578710 313634743 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470740 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(C)cc1 183344 US9150546, I-518::US9688643, I-518::US9718790, I-0527 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183344 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183344&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578621 313634744 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470741 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(CCCC(O)=O)c(=O)n1Cc1ccc(C)cc1 InChI=1S/C24H27ClN4O5/c1-15(2)34-20-11-10-18(13-19(20)25)26-22-27-23(32)28(12-4-5-21(30)31)24(33)29(22)14-17-8-6-16(3)7-9-17/h6-11,13,15H,4-5,12,14H2,1-3H3,(H,30,31)(H,26,27,32) NXLSNMXBBXKVGK-UHFFFAOYSA-N 183345 US9150546, I-519::US9688643, I-519::US9718790, I-0528 P2X purinoceptor 3 Homo sapiens 12 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183345 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183345&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578649 313634745 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470742 Cc1cc2cc(ccc2o1)\N=c1/[nH]c(=O)n(CCCC(O)=O)c(=O)n1Cc1ccc(C)cc1 InChI=1S/C24H24N4O5/c1-15-5-7-17(8-6-15)14-28-22(25-19-9-10-20-18(13-19)12-16(2)33-20)26-23(31)27(24(28)32)11-3-4-21(29)30/h5-10,12-13H,3-4,11,14H2,1-2H3,(H,29,30)(H,25,26,31) MQVCATJXUIBEEK-UHFFFAOYSA-N 183346 US9150546, I-520::US9688643, I-520::US9718790, I-0529 P2X purinoceptor 3 Homo sapiens 80 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183346 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183346&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578423 313634746 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470743 CCOC(=O)CCCn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(C)c2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C27H34N4O5/c1-6-35-24(32)8-7-15-30-26(33)29-25(28-22-13-14-23(20(5)16-22)36-18(2)3)31(27(30)34)17-21-11-9-19(4)10-12-21/h9-14,16,18H,6-8,15,17H2,1-5H3,(H,28,29,33) CBVQUWBWGAGXAO-UHFFFAOYSA-N 183347 US9150546, I-521::US9688643, I-521::US9718790, I-0530 P2X purinoceptor 3 Homo sapiens 4.00 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183347 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183347&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578914 313634747 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470744 COC(=O)C[C@H](C)n1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(Cl)c2)n(Cc2ccc(Cl)cc2)c1=O 183348 US9150546, I-522::US9688643, I-522::US9718790, I-0531 P2X purinoceptor 3 Homo sapiens 29 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183348 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183348&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578461 313634748 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470745 COC(=O)C[C@H](C)n1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O 183349 US9150546, I-523::US9688643, I-523::US9718790, I-0532 P2X purinoceptor 3 Homo sapiens 72 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183349 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183349&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578435 313634749 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470746 COC(=O)C[C@H](C)n1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O 183350 US9150546, I-524::US9688643, I-524::US9718790, I-0533 P2X purinoceptor 3 Homo sapiens 60 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183350 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183350&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578592 313634750 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470747 CC(C)Oc1ccc(cc1C)\N=c1/[nH]c(=O)n(CCCC(O)=O)c(=O)n1Cc1ccc(C)cc1 InChI=1S/C25H30N4O5/c1-16(2)34-21-12-11-20(14-18(21)4)26-23-27-24(32)28(13-5-6-22(30)31)25(33)29(23)15-19-9-7-17(3)8-10-19/h7-12,14,16H,5-6,13,15H2,1-4H3,(H,30,31)(H,26,27,32) PTNDSIGCKJDYDW-UHFFFAOYSA-N 183351 US9150546, I-525::US9688643, I-525::US9718790, I-0534 P2X purinoceptor 3 Homo sapiens 54 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183351 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183351&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578449 313634751 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470748 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n([C@@H](C)CC(O)=O)c(=O)n1Cc1ccc(Cl)cc1 183352 US9150546, I-526::US9688643, I-526::US9718790, I-0535 P2X purinoceptor 3 Homo sapiens 24 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183352 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183352&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578743 313634752 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470749 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n([C@@H](C)CC(O)=O)c(=O)n1Cc1ccc(Cl)cc1 183353 US9150546, I-527::US9688643, I-527::US9718790, I-0536 P2X purinoceptor 3 Homo sapiens 33 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183353 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183353&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578893 313634753 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470750 CC(C)Oc1ccc(cc1C)\N=c1/[nH]c(=O)n([C@@H](C)CC(O)=O)c(=O)n1Cc1ccc(Cl)cc1 183354 US9150546, I-528::US9688643, I-528::US9718790, I-0537 P2X purinoceptor 3 Homo sapiens 53 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183354 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183354&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578907 313634754 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470751 COC(=O)[C@@H](C)Cn1c(=O)nc(Nc2ccc(OC(C)C)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H27ClN4O5/c1-15(2)34-20-11-9-19(10-12-20)26-22-27-23(31)29(13-16(3)21(30)33-4)24(32)28(22)14-17-5-7-18(25)8-6-17/h5-12,15-16H,13-14H2,1-4H3,(H,26,27,31)/t16-/m0/s1 PNDUVKCLDPNYPJ-INIZCTEOSA-N 183355 US9150546, I-529::US9688643, I-529::US9718790, I-0538 P2X purinoceptor 3 Homo sapiens 22 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183355 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183355&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117900854 313634755 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470752 CCOc1ccc(Nc2nc(=O)n(C[C@H](C)C(=O)OC)c(=O)n2Cc2ccc(Cl)cc2)cc1 InChI=1S/C23H25ClN4O5/c1-4-33-19-11-9-18(10-12-19)25-21-26-22(30)28(13-15(2)20(29)32-3)23(31)27(21)14-16-5-7-17(24)8-6-16/h5-12,15H,4,13-14H2,1-3H3,(H,25,26,30)/t15-/m0/s1 LLXZMQNNOVIISR-HNNXBMFYSA-N 183356 US9150546, I-530::US9688643, I-530::US9718790, I-0539 P2X purinoceptor 3 Homo sapiens 34 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183356 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183356&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 119099069 313634756 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470753 COC(=O)[C@@H](C)Cn1c(=O)nc(Nc2ccc(OC(C)C)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H29ClN4O5/c1-15(2)35-21-11-10-20(12-16(21)3)27-23-28-24(32)30(13-17(4)22(31)34-5)25(33)29(23)14-18-6-8-19(26)9-7-18/h6-12,15,17H,13-14H2,1-5H3,(H,27,28,32)/t17-/m0/s1 GVMFNMJAZZEXOQ-KRWDZBQOSA-N 183357 US9150546, I-531::US9688643, I-531::US9718790, I-0540 P2X purinoceptor 3 Homo sapiens 10.00 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183357 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183357&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 119099070 313634757 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470754 CCOc1ccc(Nc2nc(=O)n(C[C@H](C)C(=O)OC)c(=O)n2Cc2ccc(Cl)cc2)cc1C InChI=1S/C24H27ClN4O5/c1-5-34-20-11-10-19(12-15(20)2)26-22-27-23(31)29(13-16(3)21(30)33-4)24(32)28(22)14-17-6-8-18(25)9-7-17/h6-12,16H,5,13-14H2,1-4H3,(H,26,27,31)/t16-/m0/s1 AHRHHAOVZLVQPW-INIZCTEOSA-N 183358 US9150546, I-532::US9688643, I-532::US9718790, I-0541 P2X purinoceptor 3 Homo sapiens 29 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183358 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183358&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 119099071 313634758 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470755 CCOc1ccc(Nc2nc(=O)n(C[C@H](C)C(=O)OC)c(=O)n2Cc2ccc(Cl)cc2)cc1Cl InChI=1S/C23H24Cl2N4O5/c1-4-34-19-10-9-17(11-18(19)25)26-21-27-22(31)29(12-14(2)20(30)33-3)23(32)28(21)13-15-5-7-16(24)8-6-15/h5-11,14H,4,12-13H2,1-3H3,(H,26,27,31)/t14-/m0/s1 YDMQMBMMHSDJFG-AWEZNQCLSA-N 183359 US9150546, I-533::US9688643, I-533::US9718790, I-0542 P2X purinoceptor 3 Homo sapiens 10.00 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183359 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183359&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 119099072 313634759 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470756 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc3oc(C)cc3c2)n(Cc2ccc(Cl)cc2)c1=O 183360 US9150546, I-534::US9688643, I-534::US9718790, I-0543 P2X purinoceptor 3 Homo sapiens 18 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183360 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183360&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578525 313634760 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470757 CCOc1ccc(cc1)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 183361 US9150546, I-535::US9688643, I-535::US9718790, I-0544 P2X purinoceptor 3 Homo sapiens 52 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183361 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183361&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578651 313634761 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470758 CCOc1ccc(cc1C)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 183362 US9150546, I-536::US9688643, I-536::US9718790, I-0545 P2X purinoceptor 3 Homo sapiens 46 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183362 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183362&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578788 313634762 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470759 CC(C)Oc1ccc(cc1)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 183363 US9150546, I-537::US9688643, I-537::US9718790, I-0546 P2X purinoceptor 3 Homo sapiens 19 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183363 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183363&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578598 313634763 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470760 CC(C)Oc1ccc(cc1C)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 183364 US9150546, I-538::US9688643, I-538::US9718790, I-0547 P2X purinoceptor 3 Homo sapiens 16 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183364 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183364&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578644 313634764 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470761 CCOc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 183365 US9150546, I-539::US9688643, I-539::US9718790, I-0548 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183365 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183365&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578535 313634765 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470762 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc3oc(C)cc3c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 183366 US9150546, I-540::US9688643, I-540::US9718790, I-0549 P2X purinoceptor 3 Homo sapiens 27 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183366 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183366&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578454 313634766 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470763 CC(C)Oc1ccc(cc1)\N=c1/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C24H27ClN4O5/c1-15(2)34-19-11-9-18(10-12-19)26-21-27-22(32)29(14-24(3,4)20(30)31)23(33)28(21)13-16-5-7-17(25)8-6-16/h5-12,15H,13-14H2,1-4H3,(H,30,31)(H,26,27,32) JCPCQJZKKYRYKO-UHFFFAOYSA-N 183367 US9150546, I-541::US9688643, I-541::US9718790, I-0550 P2X purinoceptor 3 Homo sapiens 58 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183367 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183367&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578444 313634767 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470764 CCOc1ccc(cc1)\N=c1/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C23H25ClN4O5/c1-4-33-18-11-9-17(10-12-18)25-20-26-21(31)28(14-23(2,3)19(29)30)22(32)27(20)13-15-5-7-16(24)8-6-15/h5-12H,4,13-14H2,1-3H3,(H,29,30)(H,25,26,31) XUZSADSANSSCJR-UHFFFAOYSA-N 183368 US9150546, I-542::US9688643, I-542::US9718790, I-0551 P2X purinoceptor 3 Homo sapiens 96 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183368 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183368&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578394 313634768 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470765 CC(C)(Cn1c(=O)[nH]\c(=N/c2ccc(OC(F)F)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O InChI=1S/C22H21ClF2N4O5/c1-22(2,17(30)31)12-29-20(32)27-19(26-15-7-9-16(10-8-15)34-18(24)25)28(21(29)33)11-13-3-5-14(23)6-4-13/h3-10,18H,11-12H2,1-2H3,(H,30,31)(H,26,27,32) GYEVZEZSHHFIPQ-UHFFFAOYSA-N 183369 US9150546, I-543::US9688643, I-543::US9718790, I-0552 P2X purinoceptor 3 Homo sapiens 172 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183369 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183369&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578802 313634769 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470766 CSc1ccc(cc1)\N=c1/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C22H23ClN4O4S/c1-22(2,18(28)29)13-27-20(30)25-19(24-16-8-10-17(32-3)11-9-16)26(21(27)31)12-14-4-6-15(23)7-5-14/h4-11H,12-13H2,1-3H3,(H,28,29)(H,24,25,30) CZLXUMOXYGNOSM-UHFFFAOYSA-N 183370 US9150546, I-544::US9688643, I-544::US9718790, I-0553 P2X purinoceptor 3 Homo sapiens 601 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183370 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183370&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578952 313634770 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470767 CC(C)Oc1ccc(Nc2nc(=O)n(CCOC3CCCCO3)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C26H30ClFN4O5/c1-17(2)37-22-11-10-20(15-21(22)28)29-24-30-25(33)31(12-14-36-23-5-3-4-13-35-23)26(34)32(24)16-18-6-8-19(27)9-7-18/h6-11,15,17,23H,3-5,12-14,16H2,1-2H3,(H,29,30,33) RKURIGKRJVTWEA-UHFFFAOYSA-N 183371 US9150546, I-545::US9688643, I-545::US9718790, I-0554 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183371 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183371&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76820961 313634771 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470768 CC(C)Oc1ccc(cc1F)\N=c1/n(C)c(=O)n(CCOC2CCCCO2)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C27H32ClFN4O5/c1-18(2)38-23-12-11-21(16-22(23)29)30-25-31(3)26(34)32(13-15-37-24-6-4-5-14-36-24)27(35)33(25)17-19-7-9-20(28)10-8-19/h7-12,16,18,24H,4-6,13-15,17H2,1-3H3/b30-25+ NYQXKNHJLZHVCJ-QCWLDUFUSA-N 183372 US9150546, I-546::US9688643, I-546::US9718790, I-0555 P2X purinoceptor 3 Homo sapiens 459 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183372 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183372&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578748 313634772 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 187799 OC(=O)c1cc(C(O)=O)c(cc1C(O)=O)C(=O)N(Cc1cccc(Oc2ccccc2)c1)[C@H]1CCCc2ccccc12 InChI=1S/C33H27NO8/c35-30(25-17-27(32(38)39)28(33(40)41)18-26(25)31(36)37)34(29-15-7-10-21-9-4-5-14-24(21)29)19-20-8-6-13-23(16-20)42-22-11-2-1-3-12-22/h1-6,8-9,11-14,16-18,29H,7,10,15,19H2,(H,36,37)(H,38,39)(H,40,41)/t29-/m0/s1 VQGBOYBIENNKMI-LJAQVGFWSA-N 86478 A-317491 P2X purinoceptor 3 Homo sapiens 10.8 PDSP Ki 10.1124/jpet.103.064907 10.7270/Q2SQ8XZR 15024037 Jarvis, MF; Bianchi, B; Uchic, JT; Cartmell, J; Lee, CH; Williams, M; Faltynek, C Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86478 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86478&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 71C 5SVR 9829395 136352527 4115 ZINC03990058 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 187800 Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1 XTWYTFMLZFPYCI-KQYNXXCUSA-N 31995 ADP::Adenosine Diphosphate (ADP)::CHEMBL14830 P2X purinoceptor 3 Homo sapiens 452 PDSP Ki 10.1124/jpet.103.064907 10.7270/Q2SQ8XZR 15024037 Jarvis, MF; Bianchi, B; Uchic, JT; Cartmell, J; Lee, CH; Williams, M; Faltynek, C Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31995 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31995&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 2WQE,3FD6,3IUC,3EHH,3GIF,3I61,3I62,3IN1,3FYH,3IG8 6022 85240621 16761 CHEMBL14830 1712 C03517 ZINC67267160 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 187801 Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)CP(O)(O)=O)[C@@H](O)[C@H]1O InChI=1S/C11H17N5O9P2/c12-9-6-10(14-2-13-9)16(3-15-6)11-8(18)7(17)5(25-11)1-24-27(22,23)4-26(19,20)21/h2-3,5,7-8,11,17-18H,1,4H2,(H,22,23)(H2,12,13,14)(H2,19,20,21)/t5-,7-,8-,11-/m1/s1 OLCWZBFDIYXLAA-IOSLPCCCSA-N 18136 ADP, alpha beta-me::AMPCPP::[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)methyl]phosphonic acid::alpha, beta-methyleneadenosine 5 -diphosphate::cid_92199 P2X purinoceptor 3 Homo sapiens >10000 PDSP Ki 10.1124/jpet.103.064907 10.7270/Q2SQ8XZR 15024037 Jarvis, MF; Bianchi, B; Uchic, JT; Cartmell, J; Lee, CH; Williams, M; Faltynek, C Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18136 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18136&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 1AV5,1DKU,2VQD,5FIT 92199 46518245 40730 5092 ZINC13527614 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 187802 Nc1ncnc2n(cnc12)C1OC(COP(O)(=O)OP(O)(S)=O)C(O)C1O InChI=1S/C10H15N5O9P2S/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(23-10)1-22-25(18,19)24-26(20,21)27/h2-4,6-7,10,16-17H,1H2,(H,18,19)(H2,11,12,13)(H2,20,21,27) HCIKUKNAJRJFOW-UHFFFAOYSA-N 86484 ADP, Beta S::CAS_123848::NSC_123848 P2X purinoceptor 3 Homo sapiens 297 PDSP Ki 10.1124/jpet.103.064907 10.7270/Q2SQ8XZR 15024037 Jarvis, MF; Bianchi, B; Uchic, JT; Cartmell, J; Lee, CH; Williams, M; Faltynek, C Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86484 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86484&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search AT4 2OLK,5O5Z,5WS4,6XIO 6912713 136352533 ZINC96135325 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 187803 Nc1ncnc2n(cnc12)C1OC(COP(O)(=O)OP(O)(=O)OCC2OC(C(O)C2O)n2cnc3c(N)ncnc23)C(O)C1O InChI=1S/C20H26N10O13P2/c21-15-9-17(25-3-23-15)29(5-27-9)19-13(33)11(31)7(41-19)1-39-44(35,36)43-45(37,38)40-2-8-12(32)14(34)20(42-8)30-6-28-10-16(22)24-4-26-18(10)30/h3-8,11-14,19-20,31-34H,1-2H2,(H,35,36)(H,37,38)(H2,21,23,25)(H2,22,24,26) AKDJDUXNKGWGAZ-UHFFFAOYSA-N 86481 AP2A::CAS_0::NSC_0 P2X purinoceptor 3 Homo sapiens >10000 PDSP Ki 10.1124/jpet.103.064907 10.7270/Q2SQ8XZR 15024037 Jarvis, MF; Bianchi, B; Uchic, JT; Cartmell, J; Lee, CH; Williams, M; Faltynek, C Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86481 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86481&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search A2D 2I2D 14464640 136352530 ZINC96135321 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 187804 Nc1ncnc2n(cnc12)C1OC(COP(O)(=O)OP(O)(=O)OP(O)(=O)OC2C(CO)OC(C2O)n2cnc3c(N)ncnc23)C(O)C1O InChI=1S/C20H27N10O16P3/c21-15-9-17(25-3-23-15)29(5-27-9)19-12(33)11(32)8(43-19)2-41-47(35,36)45-49(39,40)46-48(37,38)44-14-7(1-31)42-20(13(14)34)30-6-28-10-16(22)24-4-26-18(10)30/h3-8,11-14,19-20,31-34H,1-2H2,(H,35,36)(H,37,38)(H,39,40)(H2,21,23,25)(H2,22,24,26) IZPYLEWCCHQWIA-UHFFFAOYSA-N 86489 AP3A::CAS_3035419::NSC_3035419 P2X purinoceptor 3 Homo sapiens 1670 PDSP Ki 10.1124/jpet.103.064907 10.7270/Q2SQ8XZR 15024037 Jarvis, MF; Bianchi, B; Uchic, JT; Cartmell, J; Lee, CH; Williams, M; Faltynek, C Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86489 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86489&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 57340615 136352538 ZINC96135333 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 187805 OC1C(COP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(=O)OCC2OC(C(O)C2O)n2cnc3c4nccn4cnc23)OC(C1O)n1cnc2c3nccn3cnc12 InChI=1S/C24H28N10O19P4/c35-15-11(49-23(17(15)37)33-9-27-13-19-25-1-3-31(19)7-29-21(13)33)5-47-54(39,40)51-56(43,44)53-57(45,46)52-55(41,42)48-6-12-16(36)18(38)24(50-12)34-10-28-14-20-26-2-4-32(20)8-30-22(14)34/h1-4,7-12,15-18,23-24,35-38H,5-6H2,(H,39,40)(H,41,42)(H,43,44)(H,45,46) JTINNCIJJZFDBZ-UHFFFAOYSA-N 86483 AP4A::CAS_175692::NSC_175692 P2X purinoceptor 3 Homo sapiens 7.7 PDSP Ki 10.1124/jpet.103.064907 10.7270/Q2SQ8XZR 15024037 Jarvis, MF; Bianchi, B; Uchic, JT; Cartmell, J; Lee, CH; Williams, M; Faltynek, C Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86483 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86483&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 53462972 136352532 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 187806 Nc1ncnc2n(cnc12)C1OC(COP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(=O)OCC2OC(C(O)C2O)n2cnc3c(N)ncnc23)C(O)C1O InChI=1S/C20H29N10O22P5/c21-15-9-17(25-3-23-15)29(5-27-9)19-13(33)11(31)7(47-19)1-45-53(35,36)49-55(39,40)51-57(43,44)52-56(41,42)50-54(37,38)46-2-8-12(32)14(34)20(48-8)30-6-28-10-16(22)24-4-26-18(10)30/h3-8,11-14,19-20,31-34H,1-2H2,(H,35,36)(H,37,38)(H,39,40)(H,41,42)(H,43,44)(H2,21,23,25)(H2,22,24,26) OIMACDRJUANHTJ-UHFFFAOYSA-N 86485 AP5A::CAS_440210::NSC_440210 P2X purinoceptor 3 Homo sapiens 10.4 PDSP Ki 10.1124/jpet.103.064907 10.7270/Q2SQ8XZR 15024037 Jarvis, MF; Bianchi, B; Uchic, JT; Cartmell, J; Lee, CH; Williams, M; Faltynek, C Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86485 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86485&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search AP5 1E4V,1E4Y,4MKH,4MKF,4MKG,5XZ2,5XRU,1ZAK,1AKY,1AKE,5X6J,1P3J,1Z83,1S3G,2RGX,4W5J,4NU0,3DKV,2QAJ,2BZZ,3X2S,3DL0,3HPQ,3HPR,2OO7,5YCF,5YCD,5YCC,5YCB,4QBI,4QBH,4QBG,4QBF,3KTA,4I2I,2ORI,3OTX,6ZJE,5X6L,5X6I,2OSB,2EU8,6HAM,8BQF,3BE4,6HAP,7OWE,4X8L,4X8O,6J5S,3H86,3FB4,3RRJ,2AKY,5G3Z,1ZIP,1ZIN,1ZIO,6PSP,4TYQ,4TYP,5G41,5EJE,3AKY,2P3S,5X6K,3RQ8 2388 136352534 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 187807 Nc1ncnc2n(cnc12)C1OC(COP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(=O)OCC2OC(C(O)C2O)n2cnc3c(N)ncnc23)C(O)C1O InChI=1S/C20H30N10O25P6/c21-15-9-17(25-3-23-15)29(5-27-9)19-13(33)11(31)7(49-19)1-47-56(35,36)51-58(39,40)53-60(43,44)55-61(45,46)54-59(41,42)52-57(37,38)48-2-8-12(32)14(34)20(50-8)30-6-28-10-16(22)24-4-26-18(10)30/h3-8,11-14,19-20,31-34H,1-2H2,(H,35,36)(H,37,38)(H,39,40)(H,41,42)(H,43,44)(H,45,46)(H2,21,23,25)(H2,22,24,26) PZCFFCOJNXGTIM-UHFFFAOYSA-N 86482 AP6A::CAS_123694::NSC_123694 P2X purinoceptor 3 Homo sapiens 4.8 PDSP Ki 10.1124/jpet.103.064907 10.7270/Q2SQ8XZR 15024037 Jarvis, MF; Bianchi, B; Uchic, JT; Cartmell, J; Lee, CH; Williams, M; Faltynek, C Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86482 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86482&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search B6P 3RQH 4179055 136352531 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 187808 Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O InChI=1S/C10H16N5O13P3/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1 ZKHQWZAMYRWXGA-KQYNXXCUSA-N 2 ({[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)phosphonic acid::ATP::Brimonidine ATP::CHEMBL14249 P2X purinoceptor 3 Homo sapiens 14.6 PDSP Ki 10.1124/jpet.103.064907 10.7270/Q2SQ8XZR 15024037 Jarvis, MF; Bianchi, B; Uchic, JT; Cartmell, J; Lee, CH; Williams, M; Faltynek, C Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=2 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=2&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 1A0I,1A49,1A5U,1A82,1AQ2,1ASZ,1ATN,1ATP,1AYL,1B0U,1B38,1B39,1B76,1B8A,1BCP,1C0F,1C0G,1CSN,1D4X,1D9Z,1DEJ,1DO0,1DV2,1DY3,1E24,1E2Q,1E4G,1E79,1E8X,1EE1,1EQY,1ESQ,1ESV,1F2U,1F9A,1FIN,1FMW,1FQ1,1G21,1G3I,1G5T,1G64,1GN8,1GOL,1GTR,1GY3,1GZ3,1GZ4,1H1V,1H1W,1H3E,1H4Q,1H8H,1HCK,1HI1,1HLU,1HP1,1I7L,1II0,1IJJ,1J09,1J1Z,1J21,1J7K,1JI0,1JJV,1JKN,1JST,1JWA,1KAX,1KAY,1KAZ,1KH2,1KJ8,1KJ9,1KMN,1KO5,1KP2,1KP3,1KP8,1KVK,1KXP,1KYI,1L2T,1LCU,1LHR,1LOT,1M83,1MA9,1MAB,1MAU,1MAW,1MB9,1MDU,1MIW,1MJH,1MO8,1MV5,1N48,1N56,1N5I,1N75,1N77,1NBM,1NGE,1NGF,1NGG,1NGH,1NLV,1NM1,1NMD,1NSF,1NSY,1NYR,1O93,1O9T,1OBD,1OJL,1OL6,1OS1,1P8Z,1PHK,1PJ4,1PK8,1PX2,1Q12,1Q24,1Q97,1QHG,1QHH,1QHX,1QL6,1QMZ,1QRS,1QRT,1QRU,1QZ5,1QZ6,1R0X,1R0Z,1R10,1R4N,1R8B,1R9T,1RDQ,1RDW,1RFQ,1RGI,1RYR,1RYS,1S22,1S9I,1S9J,1SU2,1SVM,1SX3,1T44,1TC0,1TF7,1TFW,1TID,1TIL,1TQP,1TWA,1TWH,1TYQ,1U5R,1U5V,1U9I,1UA2,1UEV,1UF9,1V1B,1V3S,1VC9,1VCI,1VJC,1VJD,1W7A,1WKL,1WUA,1X01,1XDN,1XDP,1XEF,1XEX,1XF9,1XFA,1XKV,1XMI,1XMJ,1XNG,1XSC,1Y56,1Y64,1Y8P,1Y8Q,1Y8R,1YAG,1YFR,1YID,1YP3,1YTM,1YUN,1YVN,1YXQ,1Z0S,1Z7E,1ZAO,1ZFN,1ZP9,1ZYD,2A3Z,2A40,2A41,2A42,2A5Y,2A84,2AQX,2ARU,2ASM,2ASO,2ASP,2B6F,2BBO,2BBS,2BBT,2BEK,2BIY,2BTF,2BU2,2BUP,2C01,2C7E,2C8V,2C96,2C9C,2CBZ,2CCH,2CCI,2CG9,2CJA,2CJM,2CV1,2D1K,2DDO,2DRA,2DTO,2DXI,2DXT,2E5Y,2E89,2EG2,2EWW,2F02,2F43,2FAQ,2FF3,2FF6,2FGH,2FGJ,2FGK,2FSG,2FXU,2GBL,2GNK,2GWJ,2GWK,2HF4,2HIX,2HMP,2HMU,2HMW,2HS0,2HVY,2I4O,2IA6,2IAJ,2IDX,2IJM,2ILY,2IVP,2IXE,2IXF,2IXG,2IYW,2J3M,2J9C,2J9E,2J9L,2JAX,2JJX,2NPI,2NT8,2NVU,2NYJ,2O0H,2OAN,2OGX,2OH5,2OH6,2OH7,2OLQ,2OLR,2OOY,2P09,2P0X,2P55,2P9K,2P9S,2PAA,2PAV,2PBD,2PBZ,2PC9,2PHK,2PNN,2PQ1,2PXZ,2PY7,2PZE,2PZF,2PZG,2Q0D,2Q0R,2Q0U,2Q31,2Q36,2Q66,2Q7G,2Q97,2QB8,2QK4,2QKM,2QRD,2QUI,2QXL,2R6G,2R6T,2R6X,2R7L,2R86,2R9V,2RD5,2V51,2V52,2V7Q,2V92,2V9J,2VCP,2VHQ,2VHT,2VT3,2VYP,2W00,2W02,2W5G,2W5I,2YW2,2YWW,2YXU,2Z02,2Z08,2Z1U,2ZAN,2ZDQ,2ZH6,2ZHZ,3B2Q,3BG5,3BJU,3BLQ,3BU5,3BUZ,3C16,3C4W,3C4X,3C5E,3C9R,3CHW,3CI1,3CI4,3CI5,3CIP,3CIS,3CJB,3CJC,3CQD,3CRC,3CYI,3D2E,3D2F,3DAW,3DGL,3DGO,3DNT,3DWL,3DY7,3E1Y,3E7E,3EA0,3EFS,3EIU,3EKS,3EKU,3EL2,3EQB,3ETH,3F5M,3FCC,3FCE,3FDX,3FHX,3FHY,3FKQ,3FPB,3FZF,3G59,3G6V,3GBU,3GNI,3GQK,3GQN,3H1Q,3H5N,3H8V,3HED,3PGK,3PJR,3R1R,4AT1,7AT1,8ICN 5957 11108072 15422 CHEMBL14249 DB00171 1713 C03517 ZINC18456332 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 187809 CSc1nc(N)c2ncn([C@@H]3O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]3O)c2n1 InChI=1S/C11H18N5O13P3S/c1-33-11-14-8(12)5-9(15-11)16(3-13-5)10-7(18)6(17)4(27-10)2-26-31(22,23)29-32(24,25)28-30(19,20)21/h3-4,6-7,10,17-18H,2H2,1H3,(H,22,23)(H,24,25)(H2,12,14,15)(H2,19,20,21)/t4-,6-,7-,10-/m1/s1 XNOBOKJVOTYSJV-KQYNXXCUSA-N 50118232 2-MeSATP::ATP, 2-meS::CHEMBL336208 P2X purinoceptor 3 Homo sapiens 8.2 PDSP Ki 10.1124/jpet.103.064907 10.7270/Q2SQ8XZR 15024037 Jarvis, MF; Bianchi, B; Uchic, JT; Cartmell, J; Lee, CH; Williams, M; Faltynek, C Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118232 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118232&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 6AT 5SVP,5SVM,4PY0 5310983 104011569 CHEMBL336208 C03517 ZINC17654543 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 187810 Nc1ncnc2n(cnc12)C1OC(COP(O)(=O)CP(O)(=O)OP(O)(O)=O)C(O)C1O InChI=1S/C11H18N5O12P3/c12-9-6-10(14-2-13-9)16(3-15-6)11-8(18)7(17)5(27-11)1-26-29(19,20)4-30(21,22)28-31(23,24)25/h2-3,5,7-8,11,17-18H,1,4H2,(H,19,20)(H,21,22)(H2,12,13,14)(H2,23,24,25) CAWZRIXWFRFUQB-UHFFFAOYSA-N 50026203 ({[({[5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)methyl](hydroxy)phosphoryl}oxy)phosphonic acid::ATP, alpha, beta methylene::Adenosine 5'-triphosphate derivative P2X purinoceptor 3 Homo sapiens 9 PDSP Ki 10.1124/jpet.103.064907 10.7270/Q2SQ8XZR 15024037 Jarvis, MF; Bianchi, B; Uchic, JT; Cartmell, J; Lee, CH; Williams, M; Faltynek, C Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50026203 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50026203&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search APC 5ETO,5ETP,5ETT,1IH8,2PZ8,6E0N,3JZ0,2VHC,6KCK,4A3L,4A3M,4A3E,4A3F,2C5U,3NBA,7D4S,4DPG,1S76,3SEQ,6GQR,1N2B,1N2G,1N2E,6VCO,6E0L,6NAK,1WC5,1WC4,6GR1,7UTT,1YBU,1F9H,4IZ9,6UPY,5ETM,5ETS,5ETQ,5ETV,4U0Z,4X4U,4X4V,4X4R,4CWB,5CFS,5CFT,1NUS,1NUT,7XBV,6NML,6ULZ,6FGX,7YY1,6MFW,6MFX,2YYE,5XOG,4RWO,4RWN,6EWZ,5ETR,3IP0,1W48,1W49,1W4A,4I2C,4I2B,4I2E,4I2D,4I2H,5Z79,4USU,2X3F,4EWV,3HD1,4GR5,5F2V,4BY1,2QX0,2ZT6,1TMM,1S26,6N67,5ES7,4L39,3VTH,1RU2,1RU1,6C02,3HSG,4S2Y,4S2X,4CLW,4CLK,4YXJ,3OVA,3LPN,4M5G,4M5N,4M5L,4M5M,4M5J,4M5K,4M5H,4M5I,4BLT,4BLS,5TV8,5OF3,4CM0,1S0V,2PPB,3AMU,3H9J,1TUM,6VD0,1KNY,1Q19,1HQ2,3DAY,3ILJ,3ILO,6P06,5LM3,4CRJ,6GYX,6BLP,5Y0Q,3KUH,3N0Y,4CYU,2BW7,3HD2,5ETK,6D1V,3G5A,1Q0N,2O5J,1VFG,4Q85,1WC0,1WC3,3MCO,4WC2,1JGT,3HT0,3VES,4OYX,5IV3,6GP8,6S84 3104 103935937 ZINC08582307 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 187811 Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](OC(=O)c2ccc(cc2)C(=O)c2ccccc2)[C@H]1O InChI=1S/C24H24N5O15P3/c25-21-17-22(27-11-26-21)29(12-28-17)23-19(31)20(16(41-23)10-40-46(36,37)44-47(38,39)43-45(33,34)35)42-24(32)15-8-6-14(7-9-15)18(30)13-4-2-1-3-5-13/h1-9,11-12,16,19-20,23,31H,10H2,(H,36,37)(H,38,39)(H2,25,26,27)(H2,33,34,35)/t16-,19-,20-,23-/m1/s1 AWJJLYZBWRIBCZ-UGTJMOTHSA-N 86488 ATP, Bz::CAS_81790-82-1::NSC_0 P2X purinoceptor 3 Homo sapiens 7.7 PDSP Ki 10.1124/jpet.103.064907 10.7270/Q2SQ8XZR 15024037 Jarvis, MF; Bianchi, B; Uchic, JT; Cartmell, J; Lee, CH; Williams, M; Faltynek, C Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86488 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86488&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 115205 136352537 1757 C03517 ZINC65731330 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 187812 Nc1ncnc2n(cnc12)[C@H]1CC[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O1 InChI=1S/C10H16N5O11P3/c11-9-8-10(13-4-12-9)15(5-14-8)7-2-1-6(24-7)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h4-7H,1-3H2,(H,19,20)(H,21,22)(H2,11,12,13)(H2,16,17,18)/t6-,7+/m0/s1 OAKPWEUQDVLTCN-NKWVEPMBSA-N 50164644 2',3'-Dideoxyadenosine Triphosphate (Ddatp)::2',3'-dideoxyadenosine triphosphate::ATP,2',3'-dideoxy::CHEMBL1383::[[[5-(6-amino-9H-purin-9-yl)tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxyphosphonic acid::ddA-TP::ddATP P2X purinoceptor 3 Homo sapiens 406 PDSP Ki 10.1124/jpet.103.064907 10.7270/Q2SQ8XZR 15024037 Jarvis, MF; Bianchi, B; Uchic, JT; Cartmell, J; Lee, CH; Williams, M; Faltynek, C Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50164644 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50164644&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search DDS 7D4J,3LWL,3LWM,1QSY,2IMW,5TXM,5TXP,8EFK,3PO5,3THV,4X0P,3PO4 65304 104050360 CHEMBL1383 1709 C03517 ZINC13508937 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 187813 Nc1ncnc2n(cnc12)[C@H]1C[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O1 InChI=1S/C10H16N5O12P3/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(25-7)2-24-29(20,21)27-30(22,23)26-28(17,18)19/h3-7,16H,1-2H2,(H,20,21)(H,22,23)(H2,11,12,13)(H2,17,18,19)/t5-,6+,7+/m0/s1 SUYVUBYJARFZHO-RRKCRQDMSA-N 50118233 2'-deoxyadenosine 5'-(tetrahydrogen triphosphate)::ATP,2'-deoxy::CHEMBL335538::dATP P2X purinoceptor 3 Homo sapiens 180 PDSP Ki 10.1124/jpet.103.064907 10.7270/Q2SQ8XZR 15024037 Jarvis, MF; Bianchi, B; Uchic, JT; Cartmell, J; Lee, CH; Williams, M; Faltynek, C Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118233 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118233&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 15993 104011570 16284 CHEMBL335538 1760 C03517 ZINC08215662 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 187814 Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)C[C@H]1O InChI=1S/C10H16N5O12P3/c11-8-7-9(13-3-12-8)15(4-14-7)10-6(16)1-5(25-10)2-24-29(20,21)27-30(22,23)26-28(17,18)19/h3-6,10,16H,1-2H2,(H,20,21)(H,22,23)(H2,11,12,13)(H2,17,18,19)/t5-,6+,10+/m0/s1 NLIHPCYXRYQPSD-BAJZRUMYSA-N 86487 ATP,3'-deoxy::CAS_0::NSC_0 P2X purinoceptor 3 Homo sapiens 47.3 PDSP Ki 10.1124/jpet.103.064907 10.7270/Q2SQ8XZR 15024037 Jarvis, MF; Bianchi, B; Uchic, JT; Cartmell, J; Lee, CH; Williams, M; Faltynek, C Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86487 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86487&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 3AT 3ERC,3ER9,6K0R,1K90,1Q79,1Q78,4LT6,1FA0,3C23,4YVZ,1XFV,6TF3,4FHY,3N0Z,1F5A,4XJ4 65562 136352536 52316 C03517 ZINC13540910 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 187815 Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)CP(O)(O)=O)[C@@H](O)[C@H]1O InChI=1S/C11H18N5O12P3/c12-9-6-10(14-2-13-9)16(3-15-6)11-8(18)7(17)5(27-11)1-26-31(24,25)28-30(22,23)4-29(19,20)21/h2-3,5,7-8,11,17-18H,1,4H2,(H,22,23)(H,24,25)(H2,12,13,14)(H2,19,20,21)/t5-,7-,8-,11-/m1/s1 UFZTZBNSLXELAL-IOSLPCCCSA-N 18135 ({[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}methyl)phosphonic acid::AMPPCP::ATP,Beta Gamma-me::CHEMBL133463::adenylylmethylenediphosphonate P2X purinoceptor 3 Homo sapiens 387 PDSP Ki 10.1124/jpet.103.064907 10.7270/Q2SQ8XZR 15024037 Jarvis, MF; Bianchi, B; Uchic, JT; Cartmell, J; Lee, CH; Williams, M; Faltynek, C Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18135 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18135&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search ABG 1DAG,1DAH,1E22,1G3R,1GLL,1GQT,1GQY,1I44,1I58,1I5A,1I6I,1IA0,1JBV,1K3A,1KF0,1KJI,1KOF,1LII,1LIJ,1O6Y,1RFT,1SAZ,1T5S,1TZ6,1U54,1VFP,1WTC,1Z2P,1ZYU,2A9Z,2AB8,2ABS,2AFK,2BY4,2C88,2C8K,2DQS,2DWP,2HCB,2HRY,2HS4,2J4J,2OHF,2PKN,2PUL,2PUN,2PVF,2PVY,2PWL,2PY3,2PZ5,2PZP,2PZR,2Q0B 91532 46518244 40532 CHEMBL133463 4236 C13741 ZINC13473520 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 187816 Nc1ncnc2n(cnc12)C1OC(COP(O)(=O)OP(O)(=O)OP(O)(O)=S)C(O)C1O InChI=1S/C10H16N5O12P3S/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(25-10)1-24-28(18,19)26-29(20,21)27-30(22,23)31/h2-4,6-7,10,16-17H,1H2,(H,18,19)(H,20,21)(H2,11,12,13)(H2,22,23,31) NLTUCYMLOPLUHL-UHFFFAOYSA-N 86479 ATP,Gamma S::CAS_440317::NSC_440317 P2X purinoceptor 3 Homo sapiens 40.3 PDSP Ki 10.1124/jpet.103.064907 10.7270/Q2SQ8XZR 15024037 Jarvis, MF; Bianchi, B; Uchic, JT; Cartmell, J; Lee, CH; Williams, M; Faltynek, C Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86479 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86479&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search AGS 1K6M,7SGZ,2W5B,5ZR1,1MO5,1MO4,2PMI,6AHF,4Y12,3HU2,3HU3,3HU1,7NPF,6UI4,7TTS,7VCX,6VVO,4DN5,7NGC,1OYY,5GMD,6LT4,6OAX,6OAY,8DK3,8DK2,4TLB,4TLC,4TLD,4TLE,4TL8,4TL9,5NZZ,2IUT,6E10,6E11,7WAE,7WAD,7WAF,5GRB,7UJ0,7TTR,2OZE,3EQC,3EQD,7FID,4XCL,3VEY,7PT6,7E21,4O1G,1ZUN,6BS4,7NKU,6YK0,6YK1,6JDI,6JDL,2QF7,7RLH,6XLG,6XLH,7JY8,7JY9,7JY5,7JY6,7JY7,4LAC,6WQH,6SL1,6SL0,5EXS,5ZT1,7UIX,7UIW,7UIV,4KRC,8ET3,7MCA,7VAW,8A5O,8A5D,1MRU,7U19,7THV,7THJ,2GA9,5MTV,6XBZ,3E76,6WGI,6WGG,6WGC,3DQW,6Z1F,7W8G,2R8F,4JSP,6WRF,1H7U,1H74,7RLJ,7RLF,7RLC,7RLA,7RL7,6UQO,6UQE,7VCS,7VCV,7VCT,7VCU,7OIM,7UIZ,7UIY,5Z69,5L6W,4NAH,4NAU,7TIB,7TIC,7TID,4DPT,4DPU,4DPW,5H68,6JB1,7TI8,6HRC,6TSZ,7U1A,7U1P,6WSG,6QV1,6QV2,6QV4,7R7S,3ORP,8AMD,6CHS,3AV0,5C1B,5C1A,5C18,7VAX,7VAY,3C4J,4J9V,4KO8,7UQJ,7JQQ,6J7E,5VFP,4KFT,8DR6,8DR4,8DR5,8DR3,8DR0,8DR1,3WRX,6NYB,6T8B,5YWA,5YW9,5YW7,1XPU,1XPR,1XPO,1AUX,6CVL,7YWA,7PBS,7PBR,7PBQ,7PBT,7PBO,7PBN,7PBM,7PBL,6W6J,6W6H,5I9V,5C03,7OTP,3EUK,3EUJ,4KLN,6W6I,6S6V,1QHY,6O1X,6WJN,6WJD,8DQX,8DQW,1W1W,6OF3,6OF2,7US2,1XP8,3ZEU,7STB,6TMX,5F3W,5VJH,6ZIW,7Z6H,7M99,7S5E,1GJV,7ZR1,6W6G,6W6E,5DNY,3QUS,7Z34,7ST9,5OG1,7V3V,7V3U,3KFK,5YKG,5YKF,4IEE,1ISG,5O0Y,7BDI,1KJJ,7PDS,7D8I,7FD5,7FD4,5OFO,8GMT,8GMU,8GMS,7SH2,8EDW,5VFS,5VFR,5VFQ,2XJ9,7FIE,6PP6,6PP7,6PP5,6PP8,8DR7,6DJV,3WRY,6HV9,7EJW,2G2F,5A30,5XG3,1KP8,7RR9,5OEA,7Z11,8EJ4,5IT5,6ZWM,6ZWO,6M6B,3MWY,5V8F,4S0F,6RN4,6RN2,6RN3,1NJF,4CRS,7TFK,7TFJ,7TFI,7TFH,7TFL,7L6N,1XXH,1BIF,8EE6,6F0X,7L9P,6DJU,6T4H,6UKS,6SKY,6SKZ,3T2S,1MMG,5A2W,6QS8,6QS6,6QS7,6QS4,8DQZ,6Q0T,6Q0J,5FTM,5FTN,7NI6,3FZP,6OG1,4UX3,8EFV,8EFY,1SXJ,1SX3,7PBP,7FIZ,7TKU,3EIH,4UYA,2YNJ,6SDX,5ZQM,3W8Q,5O6D,4RF9,6QPW,4BWK,4BWX,4A2B,1UBF,5VYA,5VY9,6XTX,7VB0,4I81,6V4L,2ZRE,2ZRA,2ZRJ,6PO3,6PO1,6POD,6POS,7NFY,5DA9,5DAC,1KWO,1NLY,5YW8,6Z4X,6QUZ,7AKM,2ODW,6XJH,6XJI,3ORT,3ORL,3ORM,3ORO,3ORI,3ORK 2028 136352528 ZINC40552159 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 187817 Nc1ncnc2n(cnc12)C1OC(COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O)C2OC3(OC12)C(=CC(C=C3[N+]([O-])=O)=[N+]([O-])[O-])[N+]([O-])=O InChI=1S/C16H16N8O19P3/c17-13-10-14(19-4-18-13)21(5-20-10)15-12-11(7(39-15)3-38-45(34,35)43-46(36,37)42-44(31,32)33)40-16(41-12)8(23(27)28)1-6(22(25)26)2-9(16)24(29)30/h1-2,4-5,7,11-12,15H,3H2,(H6-,17,18,19,25,26,31,32,33,34,35,36,37)/q-1/p-4 LQZBDVDATBCNNN-UHFFFAOYSA-J 86486 ATP,TNP::CAS_644357::NSC_644357 P2X purinoceptor 3 Homo sapiens 7.5 PDSP Ki 10.1124/jpet.103.064907 10.7270/Q2SQ8XZR 15024037 Jarvis, MF; Bianchi, B; Uchic, JT; Cartmell, J; Lee, CH; Williams, M; Faltynek, C Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86486 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86486&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 22935685 136352535 C03517 ZINC96135329 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 187818 Nc1c(cc(Nc2ccc(Nc3nc(Cl)nc(Nc4ccccc4S(O)(=O)=O)n3)c(c2)S(O)(=O)=O)c2C(=O)c3ccccc3C(=O)c12)S(O)(=O)=O InChI=1S/C29H20ClN7O11S3/c30-27-35-28(33-16-7-3-4-8-19(16)49(40,41)42)37-29(36-27)34-17-10-9-13(11-20(17)50(43,44)45)32-18-12-21(51(46,47)48)24(31)23-22(18)25(38)14-5-1-2-6-15(14)26(23)39/h1-12,32H,31H2,(H,40,41,42)(H,43,44,45)(H,46,47,48)(H2,33,34,35,36,37) YKCWQPZFAFZLBI-UHFFFAOYSA-N 50300129 CHEMBL572528::CIBACRON BLUE::Cibacron Blue 3Ga P2X purinoceptor 3 Homo sapiens 2530 PDSP Ki 10.1124/jpet.103.064907 10.7270/Q2SQ8XZR 15024037 Jarvis, MF; Bianchi, B; Uchic, JT; Cartmell, J; Lee, CH; Williams, M; Faltynek, C Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50300129 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50300129&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search CBD 20GS,3VI7,4CF6,1QRD,3W78 172469 104154490 CHEMBL572528 DB02633 ZINC85427635 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 187819 CN(C(Cc1ccc(OS(=O)(=O)c2cccc3cnccc23)cc1)C(=O)N1CCN(CC1)c1ccccc1)S(=O)(=O)c1cccc2cnccc12 InChI=1S/C38H35N5O6S2/c1-41(50(45,46)36-11-5-7-29-26-39-19-17-33(29)36)35(38(44)43-23-21-42(22-24-43)31-9-3-2-4-10-31)25-28-13-15-32(16-14-28)49-51(47,48)37-12-6-8-30-27-40-20-18-34(30)37/h2-20,26-27,35H,21-25H2,1H3 RJVLFQBBRSMWHX-UHFFFAOYSA-N 50135426 CHEMBL130321::Isoquinoline-5-sulfonic acid 4-[2-[(isoquinoline-5-sulfonyl)-methyl-amino]-3-oxo-3-(4-phenyl-piperazin-1-yl)-propyl]-phenyl ester::KN-62 P2X purinoceptor 3 Homo sapiens >10000 PDSP Ki 10.1124/jpet.103.064907 10.7270/Q2SQ8XZR 15024037 Jarvis, MF; Bianchi, B; Uchic, JT; Cartmell, J; Lee, CH; Williams, M; Faltynek, C Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50135426 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50135426&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 3838 104025794 CHEMBL130321 ZINC04262462 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 187820 Cc1nc(N=Nc2ccc(cc2S(O)(=O)=O)S(O)(=O)=O)c(COP(O)(O)=O)c(C=O)c1O InChI=1S/C14H14N3O12PS2/c1-7-13(19)9(5-18)10(6-29-30(20,21)22)14(15-7)17-16-11-3-2-8(31(23,24)25)4-12(11)32(26,27)28/h2-5,19H,6H2,1H3,(H2,20,21,22)(H,23,24,25)(H,26,27,28) PNFZSRRRZNXSMF-UHFFFAOYSA-N 85043 CAS_149017-66-3::CHEMBL69234::NSC_6093163::PPADS P2X purinoceptor 3 Homo sapiens 3470 PDSP Ki 10.1124/jpet.103.064907 10.7270/Q2SQ8XZR 15024037 Jarvis, MF; Bianchi, B; Uchic, JT; Cartmell, J; Lee, CH; Williams, M; Faltynek, C Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=85043 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=85043&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 5478935 136351143 CHEMBL69234 ZINC18247107 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 187821 Cc1ccc(cc1NC(=O)c1cccc(NC(=O)Nc2cccc(c2)C(=O)Nc2cc(ccc2C)C(=O)Nc2ccc(c3cc(cc(c23)S([O-])(=O)=O)S([O-])(=O)=O)S([O-])(=O)=O)c1)C(=O)Nc1ccc(c2cc(cc(c12)S([O-])(=O)=O)S([O-])(=O)=O)S([O-])(=O)=O InChI=1S/C51H40N6O23S6/c1-25-9-11-29(49(60)54-37-13-15-41(83(69,70)71)35-21-33(81(63,64)65)23-43(45(35)37)85(75,76)77)19-39(25)56-47(58)27-5-3-7-31(17-27)52-51(62)53-32-8-4-6-28(18-32)48(59)57-40-20-30(12-10-26(40)2)50(61)55-38-14-16-42(84(72,73)74)36-22-34(82(66,67)68)24-44(46(36)38)86(78,79)80/h3-24H,1-2H3,(H,54,60)(H,55,61)(H,56,58)(H,57,59)(H2,52,53,62)(H,63,64,65)(H,66,67,68)(H,69,70,71)(H,72,73,74)(H,75,76,77)(H,78,79,80)/p-6 FIAFUQMPZJWCLV-UHFFFAOYSA-H 50000029 4-Methyl-8-{4-methyl-3-[3-(3-{3-[2-methyl-5-(4,6,8-trisulfo-naphthalen-1-ylcarbamoyl)-phenylcarbamoyl]-phenyl}-ureido)-benzoylamino]-benzoylamino}-naphthalene-1,3,5-trisulfonic acid; hexa-kis Sodium salt::5,5',5''-[1,3,6-naphthalenetriyltris(sulfonylimino)]tris[1,3-benzenesulfonate analogue::CHEMBL265502::SURAMIN HEXASODIUM::Suramin sodium::suramin::suramin Na P2X purinoceptor 3 Homo sapiens 1090 PDSP Ki 10.1124/jpet.103.064907 10.7270/Q2SQ8XZR 15024037 Jarvis, MF; Bianchi, B; Uchic, JT; Cartmell, J; Lee, CH; Williams, M; Faltynek, C Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50000029 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50000029&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 3943541 103914728 CHEMBL265502 C07974 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 187822 OC1C(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)OC(C1O)n1ccc(=O)[nH]c1=O InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18) PGAVKCOVUIYSFO-UHFFFAOYSA-N 50023910 ({[({[5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)phosphonic acid::1-(3,4-dihydroxy-5-triphosphoryloxymethyltetrahydro-2-furanyl)-1,2,3,4-tetrahydro-2,4-pyrimidinedione::5-azidouridine-5'-triphosphate derivative::UTP::Uridine triphosphate (UTP) P2X purinoceptor 3 Homo sapiens 2610 PDSP Ki 10.1124/jpet.103.064907 10.7270/Q2SQ8XZR 15024037 Jarvis, MF; Bianchi, B; Uchic, JT; Cartmell, J; Lee, CH; Williams, M; Faltynek, C Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50023910 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50023910&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search UTP 6IKZ,5VZ8,5VZE,5VZB,5VZH,1R8C,2ICX,4J6X,2B56,2B51,1GX6,7RNR,6CZB,6VCP,5U03,1R9S,6AEH,5Z4M,4KH1,4KGZ,7MIG,2BNF,3HIY,4AT9,4ZDJ,4ZDK,7PUB,6P71,6L8K,5IDO,4JST,3HJ1,4RY5,7RL0,2J4L,4FYY,5A9A,3PKY,6KNJ,4FH5,4FHP,6KQL,6HIW,6HIV,6HIZ,5VE7,4JLZ,7N7I,2IM2,2IM3,1V34,7WIZ,8APF,7RMV,4E80,4HOS,4HO9,4HO6,2IKF,3MX5,5WU3,5WU2,2NVZ,4LIL,7X4P,6K32,7MIV,7MIU,7MIF,7MIH,5KAL,4E7C,8AP6,8APC,8APE,8APD,8APG,8APA,8APB,8APK,8APJ,7RH8,1NB6,3OH0,2E9Z,4EP7,1TWF,4F04,8AP9,8APH,6PK4,7MII,7BIX,6OGZ,7WJ4,4BLR,7UO9,4EDR,6UU6,6UUB,6Q2Q,6TZ2,1UEI,2Q0F,6G9W,7YED,2JI5,7BES,4BPW,5Z09,4O8E,7RKH,5A2Y,7MGZ,4FYX,7X4G,7X4Q,7RMK,7BL7,7AOR,7MIP,5W0O,2YU9,5TFF 1181 103934208 C03517 ZINC03875258 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 191790 COc1ccccc1C1N(C(=O)c2[nH]nc(c12)C(C)(C)C)c1ccc(cc1)N(C)C 47079 US8575197, II-008 P2X purinoceptor 3 Homo sapiens 505 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=47079 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=47079&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 112499972 251910842 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 191791 CC(C)C(=O)C1=C(O)C(=O)N(C1c1ccccc1N1CCCC1=O)c1ccc(cc1)-c1noc(C)n1 InChI=1S/C27H26N4O5/c1-15(2)24(33)22-23(19-7-4-5-8-20(19)30-14-6-9-21(30)32)31(27(35)25(22)34)18-12-10-17(11-13-18)26-28-16(3)36-29-26/h4-5,7-8,10-13,15,23,34H,6,9,14H2,1-3H3 CIJFWTJJHFDQFU-UHFFFAOYSA-N 47080 US8575197, I-596 P2X purinoceptor 3 Homo sapiens 668 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=47080 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=47080&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365712 251910843 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224795 COc1ccccc1C1N(C(=O)c2[nH]nc(C(C)=O)c12)c1ccc(cc1)-c1ccsc1 InChI=1S/C24H19N3O3S/c1-14(28)21-20-22(26-25-21)24(29)27(23(20)18-5-3-4-6-19(18)30-2)17-9-7-15(8-10-17)16-11-12-31-13-16/h3-13,23H,1-2H3,(H,25,26) ARNNHNIPNHKWHN-UHFFFAOYSA-N 106275 US8575197, II-188 P2X purinoceptor 3 Homo sapiens 156 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106275 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106275&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58366055 174008586 ZINC96177196 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224796 COc1ccccc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)C)c1ccc(cn1)-c1ccoc1 InChI=1S/C25H24N4O3/c1-25(2,3)23-20-21(27-28-23)24(30)29(22(20)17-7-5-6-8-18(17)31-4)19-10-9-15(13-26-19)16-11-12-32-14-16/h5-14,22H,1-4H3,(H,27,28) JHHFZULEBXULFH-UHFFFAOYSA-N 106334 US8575197, II-247 P2X purinoceptor 3 Homo sapiens 33 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106334 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106334&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365610 174008645 ZINC96177254 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224797 COc1ccccc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)C)c1ccc(cn1)-c1ccsc1 InChI=1S/C25H24N4O2S/c1-25(2,3)23-20-21(27-28-23)24(30)29(22(20)17-7-5-6-8-18(17)31-4)19-10-9-15(13-26-19)16-11-12-32-14-16/h5-14,22H,1-4H3,(H,27,28) ZIPVULUFMGAYPE-UHFFFAOYSA-N 106335 US8575197, II-248 P2X purinoceptor 3 Homo sapiens 13 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106335 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106335&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365907 174008646 ZINC96177255 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224798 COc1ccccc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)CO)c1ccc(cn1)-c1ccoc1 InChI=1S/C25H24N4O4/c1-25(2,14-30)23-20-21(27-28-23)24(31)29(22(20)17-6-4-5-7-18(17)32-3)19-9-8-15(12-26-19)16-10-11-33-13-16/h4-13,22,30H,14H2,1-3H3,(H,27,28) IALCMYQRORYJCE-UHFFFAOYSA-N 106337 US8575197, II-250 P2X purinoceptor 3 Homo sapiens 43 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106337 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106337&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58366026 174008648 ZINC96177257 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224799 COc1ccccc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)CO)c1ccc(cn1)-c1ccsc1 InChI=1S/C25H24N4O3S/c1-25(2,14-30)23-20-21(27-28-23)24(31)29(22(20)17-6-4-5-7-18(17)32-3)19-9-8-15(12-26-19)16-10-11-33-13-16/h4-13,22,30H,14H2,1-3H3,(H,27,28) NJXAWZWSXFWAJD-UHFFFAOYSA-N 106338 US8575197, II-251 P2X purinoceptor 3 Homo sapiens 8 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106338 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106338&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365315 174008649 ZINC96177258 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224800 COc1ccccc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)C)c1ccc(nc1)-c1ccoc1 InChI=1S/C25H24N4O3/c1-25(2,3)23-20-21(27-28-23)24(30)29(22(20)17-7-5-6-8-19(17)31-4)16-9-10-18(26-13-16)15-11-12-32-14-15/h5-14,22H,1-4H3,(H,27,28) DNPNEEZHBAHQJD-UHFFFAOYSA-N 106340 US8575197, II-253 P2X purinoceptor 3 Homo sapiens 20 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106340 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106340&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365747 174008651 ZINC96177260 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224801 COc1ccccc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)C)c1ccc(nc1)-c1ccsc1 InChI=1S/C25H24N4O2S/c1-25(2,3)23-20-21(27-28-23)24(30)29(22(20)17-7-5-6-8-19(17)31-4)16-9-10-18(26-13-16)15-11-12-32-14-15/h5-14,22H,1-4H3,(H,27,28) OIYJBJCEAHVBNG-UHFFFAOYSA-N 106341 US8575197, II-254 P2X purinoceptor 3 Homo sapiens 2 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106341 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106341&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365410 174008652 ZINC96177261 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224802 COc1ccccc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)C)c1ccc(nc1)-c1cccs1 InChI=1S/C25H24N4O2S/c1-25(2,3)23-20-21(27-28-23)24(30)29(22(20)16-8-5-6-9-18(16)31-4)15-11-12-17(26-14-15)19-10-7-13-32-19/h5-14,22H,1-4H3,(H,27,28) PLRRCNGFAOUNCE-UHFFFAOYSA-N 106342 US8575197, II-255 P2X purinoceptor 3 Homo sapiens 3 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106342 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106342&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365442 174008653 ZINC96177262 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224803 COc1ccccc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)C)c1ccc(cn1)-c1cccs1 InChI=1S/C25H24N4O2S/c1-25(2,3)23-20-21(27-28-23)24(30)29(22(20)16-8-5-6-9-17(16)31-4)19-12-11-15(14-26-19)18-10-7-13-32-18/h5-14,22H,1-4H3,(H,27,28) CYBSKVGCUZMFRA-UHFFFAOYSA-N 106343 US8575197, II-256 P2X purinoceptor 3 Homo sapiens 18 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106343 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106343&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365805 174008654 ZINC96177263 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224804 COc1ccccc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)C)c1ccc(cn1)-c1ccco1 InChI=1S/C25H24N4O3/c1-25(2,3)23-20-21(27-28-23)24(30)29(22(20)16-8-5-6-9-18(16)31-4)19-12-11-15(14-26-19)17-10-7-13-32-17/h5-14,22H,1-4H3,(H,27,28) LFNKDZAFKFIZNX-UHFFFAOYSA-N 106344 US8575197, II-257 P2X purinoceptor 3 Homo sapiens 33 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106344 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106344&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58366075 174008655 ZINC96177264 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224805 COc1ccccc1C1N(C(=O)c2n[nH]c(c12)C(C)(CO)CO)c1ccc(cc1)-c1ccon1 InChI=1S/C25H24N4O5/c1-25(13-30,14-31)23-20-21(26-27-23)24(32)29(22(20)17-5-3-4-6-19(17)33-2)16-9-7-15(8-10-16)18-11-12-34-28-18/h3-12,22,30-31H,13-14H2,1-2H3,(H,26,27) JUOGKKFFOPMFTH-UHFFFAOYSA-N 106345 US8575197, II-258 P2X purinoceptor 3 Homo sapiens 304 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106345 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106345&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365765 174008656 ZINC96177265 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224806 COc1ncccc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)C)c1ccc(Br)cn1 InChI=1S/C20H20BrN5O2/c1-20(2,3)17-14-15(24-25-17)19(27)26(13-8-7-11(21)10-23-13)16(14)12-6-5-9-22-18(12)28-4/h5-10,16H,1-4H3,(H,24,25) ADWNQHSDAGSUJD-UHFFFAOYSA-N 106346 US8575197, II-259 P2X purinoceptor 3 Homo sapiens 410 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106346 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106346&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365467 174008657 ZINC96177266 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224807 COc1ncccc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)C)c1ccc(cn1)-c1cccs1 InChI=1S/C24H23N5O2S/c1-24(2,3)21-18-19(27-28-21)23(30)29(20(18)15-7-5-11-25-22(15)31-4)17-10-9-14(13-26-17)16-8-6-12-32-16/h5-13,20H,1-4H3,(H,27,28) HLJVKGCDNMYOEF-UHFFFAOYSA-N 106347 US8575197, II-260 P2X purinoceptor 3 Homo sapiens 36 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106347 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106347&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365336 174008658 ZINC96177267 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224808 COc1ncccc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)C)c1ccc(cn1)-c1ccoc1 InChI=1S/C24H23N5O3/c1-24(2,3)21-18-19(27-28-21)23(30)29(20(18)16-6-5-10-25-22(16)31-4)17-8-7-14(12-26-17)15-9-11-32-13-15/h5-13,20H,1-4H3,(H,27,28) HIJQYWQBFFPIBP-UHFFFAOYSA-N 106348 US8575197, II-261 P2X purinoceptor 3 Homo sapiens 140 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106348 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106348&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58366115 174008659 ZINC96177268 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224809 COc1ncccc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)C)c1ccc(cn1)-c1ccsc1 InChI=1S/C24H23N5O2S/c1-24(2,3)21-18-19(27-28-21)23(30)29(20(18)16-6-5-10-25-22(16)31-4)17-8-7-14(12-26-17)15-9-11-32-13-15/h5-13,20H,1-4H3,(H,27,28) HBNSFXDJZJODHG-UHFFFAOYSA-N 106349 US8575197, II-262 P2X purinoceptor 3 Homo sapiens 39 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106349 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106349&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365468 174008660 ZINC96177269 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224810 COc1ncccc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)C)c1ccc(cn1)-c1ccco1 InChI=1S/C24H23N5O3/c1-24(2,3)21-18-19(27-28-21)23(30)29(20(18)15-7-5-11-25-22(15)31-4)17-10-9-14(13-26-17)16-8-6-12-32-16/h5-13,20H,1-4H3,(H,27,28) XRMCSIFZVBXVPE-UHFFFAOYSA-N 106350 US8575197, II-263 P2X purinoceptor 3 Homo sapiens 108 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106350 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106350&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365599 174008661 ZINC96177270 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224811 COc1ccccc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)CO)c1ccc(cn1)-c1cccs1 InChI=1S/C25H24N4O3S/c1-25(2,14-30)23-20-21(27-28-23)24(31)29(22(20)16-7-4-5-8-17(16)32-3)19-11-10-15(13-26-19)18-9-6-12-33-18/h4-13,22,30H,14H2,1-3H3,(H,27,28) AEDXKDWHWKKOBY-UHFFFAOYSA-N 106351 US8575197, II-264 P2X purinoceptor 3 Homo sapiens 11 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106351 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106351&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365988 174008662 ZINC96177271 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224812 COc1ccccc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)CO)c1ccc(cn1)-c1ccco1 InChI=1S/C25H24N4O4/c1-25(2,14-30)23-20-21(27-28-23)24(31)29(22(20)16-7-4-5-8-18(16)32-3)19-11-10-15(13-26-19)17-9-6-12-33-17/h4-13,22,30H,14H2,1-3H3,(H,27,28) RQTQJXFACSGKJS-UHFFFAOYSA-N 106352 US8575197, II-265 P2X purinoceptor 3 Homo sapiens 31 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106352 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106352&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365445 174008663 ZINC96177272 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224813 COc1ccccc1C1N(C(=O)c2n[nH]c(c12)C(C)(CO)CO)c1ccc(cc1)-c1ccsc1 InChI=1S/C26H25N3O4S/c1-26(14-30,15-31)24-21-22(27-28-24)25(32)29(23(21)19-5-3-4-6-20(19)33-2)18-9-7-16(8-10-18)17-11-12-34-13-17/h3-13,23,30-31H,14-15H2,1-2H3,(H,27,28) OWILRKBPDYZTKU-UHFFFAOYSA-N 106353 US8575197, II-266 P2X purinoceptor 3 Homo sapiens 7 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106353 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106353&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365522 174008664 ZINC96177273 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224814 COc1ncccc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)C)c1ccc(nc1)-c1ccsc1 InChI=1S/C24H23N5O2S/c1-24(2,3)21-18-19(27-28-21)23(30)29(20(18)16-6-5-10-25-22(16)31-4)15-7-8-17(26-12-15)14-9-11-32-13-14/h5-13,20H,1-4H3,(H,27,28) VQVTVRRFKOKARY-UHFFFAOYSA-N 106355 US8575197, II-268 P2X purinoceptor 3 Homo sapiens 24 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106355 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106355&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365800 174008666 ZINC96177275 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224815 COc1ncccc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)C)c1ccc(nc1)-c1ccoc1 InChI=1S/C24H23N5O3/c1-24(2,3)21-18-19(27-28-21)23(30)29(20(18)16-6-5-10-25-22(16)31-4)15-7-8-17(26-12-15)14-9-11-32-13-14/h5-13,20H,1-4H3,(H,27,28) GAFHFEQHNQIHRK-UHFFFAOYSA-N 106356 US8575197, II-269 P2X purinoceptor 3 Homo sapiens 363 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106356 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106356&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365675 174008667 ZINC96177276 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224816 COc1ncccc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)C)c1ccc(nc1)-c1cccs1 InChI=1S/C24H23N5O2S/c1-24(2,3)21-18-19(27-28-21)23(30)29(20(18)15-7-5-11-25-22(15)31-4)14-9-10-16(26-13-14)17-8-6-12-32-17/h5-13,20H,1-4H3,(H,27,28) DPOBFAZXVTXVTO-UHFFFAOYSA-N 106357 US8575197, II-270 P2X purinoceptor 3 Homo sapiens 25 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106357 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106357&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365436 174008668 ZINC96177277 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224817 COc1ncccc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)C)c1ccc(nc1)-c1ccco1 InChI=1S/C24H23N5O3/c1-24(2,3)21-18-19(27-28-21)23(30)29(20(18)15-7-5-11-25-22(15)31-4)14-9-10-16(26-13-14)17-8-6-12-32-17/h5-13,20H,1-4H3,(H,27,28) XMVKTHNWRJIGOA-UHFFFAOYSA-N 106358 US8575197, II-271 P2X purinoceptor 3 Homo sapiens 153 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106358 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106358&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365842 174008669 ZINC96177278 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224818 COc1ccccc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)C)c1ccc(cc1)-c1ccsc1Cl InChI=1S/C26H24ClN3O2S/c1-26(2,3)23-20-21(28-29-23)25(31)30(22(20)18-7-5-6-8-19(18)32-4)16-11-9-15(10-12-16)17-13-14-33-24(17)27/h5-14,22H,1-4H3,(H,28,29) FPSPFIZZDABGCF-UHFFFAOYSA-N 106359 US8575197, II-272 P2X purinoceptor 3 Homo sapiens 392 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106359 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106359&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365458 174008670 ZINC96177279 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224819 COc1ccccc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)C)c1ccc(cc1)-c1csc(C)c1 InChI=1S/C27H27N3O2S/c1-16-14-18(15-33-16)17-10-12-19(13-11-17)30-24(20-8-6-7-9-21(20)32-5)22-23(26(30)31)28-29-25(22)27(2,3)4/h6-15,24H,1-5H3,(H,28,29) NARHETUSVPAYTM-UHFFFAOYSA-N 106361 US8575197, II-274 P2X purinoceptor 3 Homo sapiens 19 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106361 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106361&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58366025 174008672 ZINC96177281 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224820 COc1ccccc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)C)c1ccc(cc1)-c1ccc(C)s1 InChI=1S/C27H27N3O2S/c1-16-10-15-21(33-16)17-11-13-18(14-12-17)30-24(19-8-6-7-9-20(19)32-5)22-23(26(30)31)28-29-25(22)27(2,3)4/h6-15,24H,1-5H3,(H,28,29) ADVXHRDMCHUXKQ-UHFFFAOYSA-N 106362 US8575197, II-275 P2X purinoceptor 3 Homo sapiens 27 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106362 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106362&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365778 174008673 ZINC96177282 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224821 COCCOCc1ncccc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)C)c1ccc(cc1)-c1ccsc1 InChI=1S/C28H30N4O3S/c1-28(2,3)26-23-24(30-31-26)27(33)32(20-9-7-18(8-10-20)19-11-15-36-17-19)25(23)21-6-5-12-29-22(21)16-35-14-13-34-4/h5-12,15,17,25H,13-14,16H2,1-4H3,(H,30,31) AIMGMPQTFBTOJQ-UHFFFAOYSA-N 106364 US8575197, II-277 P2X purinoceptor 3 Homo sapiens 274 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106364 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106364&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365757 174008675 ZINC96177284 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224822 COCCOc1ncccc1C1N(C(=O)c2n[nH]c(C(C)C)c12)c1ccc(cc1)-c1ccsc1 InChI=1S/C26H26N4O3S/c1-16(2)22-21-23(29-28-22)26(31)30(19-8-6-17(7-9-19)18-10-14-34-15-18)24(21)20-5-4-11-27-25(20)33-13-12-32-3/h4-11,14-16,24H,12-13H2,1-3H3,(H,28,29) CFOFWWNVKYJZFM-UHFFFAOYSA-N 106365 US8575197, II-278 P2X purinoceptor 3 Homo sapiens 13 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106365 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106365&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365731 174008676 ZINC96177285 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224823 COCCOc1ncccc1C1N(C(=O)c2n[nH]c(C(C)C)c12)c1ccc(cc1)-c1ccon1 InChI=1S/C25H25N5O4/c1-15(2)21-20-22(28-27-21)25(31)30(17-8-6-16(7-9-17)19-10-12-34-29-19)23(20)18-5-4-11-26-24(18)33-14-13-32-3/h4-12,15,23H,13-14H2,1-3H3,(H,27,28) BUJBNDIUVHYUIF-UHFFFAOYSA-N 106366 US8575197, II-279 P2X purinoceptor 3 Homo sapiens 378 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106366 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106366&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58366140 174008677 ZINC96177286 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224824 COCCOc1ncccc1C1N(C(=O)c2n[nH]c(C(C)C)c12)c1ccc(cc1)-c1noc(C)n1 InChI=1S/C25H26N6O4/c1-14(2)20-19-21(29-28-20)25(32)31(17-9-7-16(8-10-17)23-27-15(3)35-30-23)22(19)18-6-5-11-26-24(18)34-13-12-33-4/h5-11,14,22H,12-13H2,1-4H3,(H,28,29) SKUWSQVEBFRIHW-UHFFFAOYSA-N 106367 US8575197, II-280 P2X purinoceptor 3 Homo sapiens 244 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106367 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106367&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365455 174008678 ZINC96177287 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224825 COCCOc1ncccc1C1N(C(=O)c2n[nH]c(C(C)C)c12)c1ccc(cc1)-c1nc(C)no1 InChI=1S/C25H26N6O4/c1-14(2)20-19-21(29-28-20)25(32)31(17-9-7-16(8-10-17)23-27-15(3)30-35-23)22(19)18-6-5-11-26-24(18)34-13-12-33-4/h5-11,14,22H,12-13H2,1-4H3,(H,28,29) BGUYTVKMPNZEKQ-UHFFFAOYSA-N 106368 US8575197, II-281 P2X purinoceptor 3 Homo sapiens 664 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106368 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106368&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365684 174008679 ZINC96177288 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224076 CCOC(=O)c1ccc(cc1)N1C(C(C(=O)C(C)(C)C)C(=O)C1=O)c1ccccc1OC InChI=1S/C25H27NO6/c1-6-32-24(30)15-11-13-16(14-12-15)26-20(17-9-7-8-10-18(17)31-5)19(21(27)23(26)29)22(28)25(2,3)4/h7-14,19-20H,6H2,1-5H3 XKHNTZZCAORYMH-UHFFFAOYSA-N 105491 US8575197, I-001 P2X purinoceptor 3 Homo sapiens 3.2e+2 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105491 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105491&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808201 174007802 ZINC96176361 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224077 CCC(CC)C1C(C(=O)c2ccc(cc2)C(=O)N(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1noc(C)n1 InChI=1S/C28H30N4O5/c1-6-17(7-2)23-22(24(33)18-8-10-20(11-9-18)27(35)31(4)5)25(34)28(36)32(23)21-14-12-19(13-15-21)26-29-16(3)37-30-26/h8-15,17,22-23H,6-7H2,1-5H3 NFBAEMGMHRZVNJ-UHFFFAOYSA-N 105492 US8575197, I-002 P2X purinoceptor 3 Homo sapiens 2.4e+2 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105492 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105492&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 45141869 174007803 ZINC96176362 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224078 CCC(CC)C1C(C(=O)c2ccc(cc2)C(=O)N(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccon1 InChI=1S/C28H29N3O5/c1-5-17(6-2)24-23(25(32)19-7-9-20(10-8-19)27(34)30(3)4)26(33)28(35)31(24)21-13-11-18(12-14-21)22-15-16-36-29-22/h7-17,23-24H,5-6H2,1-4H3 ZOLTUYLGRNXDDG-UHFFFAOYSA-N 105493 US8575197, I-003 P2X purinoceptor 3 Homo sapiens 40 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105493 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105493&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 45141870 174007804 ZINC96176363 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224079 CCNC(=O)c1ccc(cc1)C(=O)C1C(C(CC)CC)N(C(=O)C1=O)c1ccc(cc1)-c1ccon1 InChI=1S/C28H29N3O5/c1-4-17(5-2)24-23(25(32)19-7-9-20(10-8-19)27(34)29-6-3)26(33)28(35)31(24)21-13-11-18(12-14-21)22-15-16-36-30-22/h7-17,23-24H,4-6H2,1-3H3,(H,29,34) YWOKYOUVNVDYSC-UHFFFAOYSA-N 105494 US8575197, I-004 P2X purinoceptor 3 Homo sapiens 12 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105494 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105494&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 45141685 174007805 ZINC96176364 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224080 CC(C)(C)C(=O)C1=C(O)C(=O)N(C1c1cccc[n+]1[O-])c1ccc(cc1)-c1ccon1 InChI=1S/C23H21N3O5/c1-23(2,3)21(28)18-19(17-6-4-5-12-25(17)30)26(22(29)20(18)27)15-9-7-14(8-10-15)16-11-13-31-24-16/h4-13,19,27H,1-3H3 QCVPDJLEOGRDIR-UHFFFAOYSA-N 105495 US8575197, I-005 P2X purinoceptor 3 Homo sapiens 247 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105495 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105495&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365327 174007806 ZINC96176365 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224081 CCCC(CCC)C1C(C(=O)c2ccc(CO)cc2)C(=O)C(=O)N1c1ccc(cc1)-c1ccon1 InChI=1S/C28H30N2O5/c1-3-5-20(6-4-2)25-24(26(32)21-9-7-18(17-31)8-10-21)27(33)28(34)30(25)22-13-11-19(12-14-22)23-15-16-35-29-23/h7-16,20,24-25,31H,3-6,17H2,1-2H3 QKKGAZVBGRKGPO-UHFFFAOYSA-N 105496 US8575197, I-006 P2X purinoceptor 3 Homo sapiens 27 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105496 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105496&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 45141871 174007807 ZINC96176366 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224082 CCCCC(CCCC)C1C(C(=O)c2ccc(CO)cc2)C(=O)C(=O)N1c1ccc(cc1)-c1ccon1 InChI=1S/C30H34N2O5/c1-3-5-7-22(8-6-4-2)27-26(28(34)23-11-9-20(19-33)10-12-23)29(35)30(36)32(27)24-15-13-21(14-16-24)25-17-18-37-31-25/h9-18,22,26-27,33H,3-8,19H2,1-2H3 DLBSADYRTNZKDY-UHFFFAOYSA-N 105497 US8575197, I-007 P2X purinoceptor 3 Homo sapiens 100 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105497 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105497&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808202 174007808 ZINC96176367 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224083 CCC(CC)C1C(C(=O)c2ccc(cc2)C(=O)NCCO)C(=O)C(=O)N1c1ccc(cc1)-c1ccon1 InChI=1S/C28H29N3O6/c1-3-17(4-2)24-23(25(33)19-5-7-20(8-6-19)27(35)29-14-15-32)26(34)28(36)31(24)21-11-9-18(10-12-21)22-13-16-37-30-22/h5-13,16-17,23-24,32H,3-4,14-15H2,1-2H3,(H,29,35) FRUGYWQPFGZXNP-UHFFFAOYSA-N 105498 US8575197, I-008 P2X purinoceptor 3 Homo sapiens 14 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105498 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105498&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808203 174007809 C04080 ZINC96176368 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224084 COc1ccc(cc1)C(=O)C1C(C2CCCCC2)N(C(=O)C1=O)c1nc2ccc(OC)cc2s1 InChI=1S/C26H26N2O5S/c1-32-17-10-8-16(9-11-17)23(29)21-22(15-6-4-3-5-7-15)28(25(31)24(21)30)26-27-19-13-12-18(33-2)14-20(19)34-26/h8-15,21-22H,3-7H2,1-2H3 HIMHXZLIBPKMSI-UHFFFAOYSA-N 105499 US8575197, I-009 P2X purinoceptor 3 Homo sapiens 14 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105499 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105499&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808204 174007810 ZINC96176369 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224085 COc1ccccc1C1C(C(=O)C(F)(F)F)C(=O)C(=O)N1c1ccc(cc1)-c1ccon1 InChI=1S/C22H15F3N2O5/c1-31-16-5-3-2-4-14(16)18-17(20(29)22(23,24)25)19(28)21(30)27(18)13-8-6-12(7-9-13)15-10-11-32-26-15/h2-11,17-18H,1H3 XYWTWQRTNSXXMQ-UHFFFAOYSA-N 105500 US8575197, I-010 P2X purinoceptor 3 Homo sapiens 595 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105500 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105500&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808205 174007811 ZINC96176370 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224086 COc1cc(F)ccc1C1C(C(=O)C(C)(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccon1 InChI=1S/C25H23FN2O5/c1-25(2,3)23(30)20-21(17-10-7-15(26)13-19(17)32-4)28(24(31)22(20)29)16-8-5-14(6-9-16)18-11-12-33-27-18/h5-13,20-21H,1-4H3 BOLKBVPKOJPKHD-UHFFFAOYSA-N 105501 US8575197, I-011 P2X purinoceptor 3 Homo sapiens 270 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105501 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105501&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808206 174007812 ZINC96176371 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224087 COc1ccc(cc1)C(=O)C1C(C2CCCCC2)N(C(=O)C1=O)c1ccc2[nH]ccc2c1 InChI=1S/C26H26N2O4/c1-32-20-10-7-17(8-11-20)24(29)22-23(16-5-3-2-4-6-16)28(26(31)25(22)30)19-9-12-21-18(15-19)13-14-27-21/h7-16,22-23,27H,2-6H2,1H3 HRYFWJRZVDXNGZ-UHFFFAOYSA-N 105502 US8575197, I-012 P2X purinoceptor 3 Homo sapiens 340 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105502 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105502&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808207 174007813 ZINC96176372 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224088 COc1ccc(cc1)C(=O)C1C(C2CCCCC2)N(C(=O)C1=O)c1ccc(cc1)-c1cccn1C InChI=1S/C29H30N2O4/c1-30-18-6-9-24(30)19-10-14-22(15-11-19)31-26(20-7-4-3-5-8-20)25(28(33)29(31)34)27(32)21-12-16-23(35-2)17-13-21/h6,9-18,20,25-26H,3-5,7-8H2,1-2H3 CSCKBILTKMGMLO-UHFFFAOYSA-N 105504 US8575197, I-014 P2X purinoceptor 3 Homo sapiens 134 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105504 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105504&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808208 174007815 ZINC96176374 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224089 COc1ccc(cc1)C(=O)C1C(C2CCCCC2)N(C(=O)C1=O)c1ccc(cc1)-c1ccco1 InChI=1S/C28H27NO5/c1-33-22-15-11-20(12-16-22)26(30)24-25(19-6-3-2-4-7-19)29(28(32)27(24)31)21-13-9-18(10-14-21)23-8-5-17-34-23/h5,8-17,19,24-25H,2-4,6-7H2,1H3 IZNRADMKQGVGKI-UHFFFAOYSA-N 105505 US8575197, I-015 P2X purinoceptor 3 Homo sapiens 12 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105505 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105505&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808209 174007816 ZINC96176375 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224090 Brc1ccc(cc1)C(=O)C1C(C2CCCCC2)N(C(=O)C1=O)c1ccc(cc1)-c1ccon1 InChI=1S/C26H23BrN2O4/c27-19-10-6-18(7-11-19)24(30)22-23(17-4-2-1-3-5-17)29(26(32)25(22)31)20-12-8-16(9-13-20)21-14-15-33-28-21/h6-15,17,22-23H,1-5H2 LGLKQEOSBZQPJD-UHFFFAOYSA-N 105506 US8575197, I-016 P2X purinoceptor 3 Homo sapiens 79 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105506 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105506&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808210 174007817 ZINC96176376 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224091 CC(C)(C)C(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1ccon1)c1ccccc1OC(F)(F)F InChI=1S/C25H21F3N2O5/c1-24(2,3)22(32)19-20(16-6-4-5-7-18(16)35-25(26,27)28)30(23(33)21(19)31)15-10-8-14(9-11-15)17-12-13-34-29-17/h4-13,19-20H,1-3H3 AYFVDIRYASJJSV-UHFFFAOYSA-N 105509 US8575197, I-019 P2X purinoceptor 3 Homo sapiens 132 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105509 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105509&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808211 174007820 ZINC96176379 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224092 COc1ccc(cc1)C(=O)C1C(C2CCCCC2)N(C(=O)C1=O)c1ccc(cc1)-c1nc(C)no1 InChI=1S/C27H27N3O5/c1-16-28-26(35-29-16)19-8-12-20(13-9-19)30-23(17-6-4-3-5-7-17)22(25(32)27(30)33)24(31)18-10-14-21(34-2)15-11-18/h8-15,17,22-23H,3-7H2,1-2H3 MTFCHTQRYHVELT-UHFFFAOYSA-N 105510 US8575197, I-020 P2X purinoceptor 3 Homo sapiens 21 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105510 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105510&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808212 174007821 ZINC96176380 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224093 COc1ccc(F)cc1C1C(C(=O)C(C)(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccon1 InChI=1S/C25H23FN2O5/c1-25(2,3)23(30)20-21(17-13-15(26)7-10-19(17)32-4)28(24(31)22(20)29)16-8-5-14(6-9-16)18-11-12-33-27-18/h5-13,20-21H,1-4H3 MKGGSNRMAQDKEQ-UHFFFAOYSA-N 105511 US8575197, I-021 P2X purinoceptor 3 Homo sapiens 382 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105511 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105511&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808213 174007822 ZINC96176381 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224094 FC(F)(F)Oc1ccc(cc1)C(=O)C1C(C2CCCCC2)N(C(=O)C1=O)c1ccc(cc1)-c1ccon1 InChI=1S/C27H23F3N2O5/c28-27(29,30)37-20-12-8-18(9-13-20)24(33)22-23(17-4-2-1-3-5-17)32(26(35)25(22)34)19-10-6-16(7-11-19)21-14-15-36-31-21/h6-15,17,22-23H,1-5H2 AEJNJJVEZMZWMV-UHFFFAOYSA-N 105516 US8575197, I-026 P2X purinoceptor 3 Homo sapiens 339 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105516 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105516&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808214 174007827 ZINC96176386 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224095 COc1ccc(cc1)C(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1cc(C)no1)c1ccccc1OC InChI=1S/C29H24N2O6/c1-17-16-24(37-30-17)18-8-12-20(13-9-18)31-26(22-6-4-5-7-23(22)36-3)25(28(33)29(31)34)27(32)19-10-14-21(35-2)15-11-19/h4-16,25-26H,1-3H3 YGFDRVPYXNZANO-UHFFFAOYSA-N 105517 US8575197, I-027 P2X purinoceptor 3 Homo sapiens 40 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105517 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105517&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808215 174007828 ZINC96176387 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224096 COc1ccc(cc1)C(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)C1=NCCS1)c1ccccc1OC InChI=1S/C28H24N2O5S/c1-34-20-13-9-17(10-14-20)25(31)23-24(21-5-3-4-6-22(21)35-2)30(28(33)26(23)32)19-11-7-18(8-12-19)27-29-15-16-36-27/h3-14,23-24H,15-16H2,1-2H3 DMZDHFRORPFZGT-UHFFFAOYSA-N 105518 US8575197, I-028 P2X purinoceptor 3 Homo sapiens 75 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105518 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105518&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808216 174007829 ZINC96176388 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224097 COc1ccc(cc1)C(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1nccs1)c1ccccc1OC InChI=1S/C28H22N2O5S/c1-34-20-13-9-17(10-14-20)25(31)23-24(21-5-3-4-6-22(21)35-2)30(28(33)26(23)32)19-11-7-18(8-12-19)27-29-15-16-36-27/h3-16,23-24H,1-2H3 IWHTVHQDOCLOMB-UHFFFAOYSA-N 105519 US8575197, I-029 P2X purinoceptor 3 Homo sapiens 160 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105519 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105519&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808217 174007830 ZINC96176389 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224098 COc1ccc(cc1)C(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1noc(C)n1)c1ccccc1OC InChI=1S/C28H23N3O6/c1-16-29-27(30-37-16)18-8-12-19(13-9-18)31-24(21-6-4-5-7-22(21)36-3)23(26(33)28(31)34)25(32)17-10-14-20(35-2)15-11-17/h4-15,23-24H,1-3H3 GZAQEEMPLBDWAC-UHFFFAOYSA-N 105520 US8575197, I-030 P2X purinoceptor 3 Homo sapiens 53 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105520 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105520&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808218 174007831 ZINC96176390 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224099 COc1ccccc1C1C(C(=O)C2(CO)CCCCC2)C(=O)C(=O)N1c1ccc(cc1)-c1ccon1 InChI=1S/C28H28N2O6/c1-35-22-8-4-3-7-20(22)24-23(26(33)28(17-31)14-5-2-6-15-28)25(32)27(34)30(24)19-11-9-18(10-12-19)21-13-16-36-29-21/h3-4,7-13,16,23-24,31H,2,5-6,14-15,17H2,1H3 MKNFXMVHPGKFRD-UHFFFAOYSA-N 105521 US8575197, I-031 P2X purinoceptor 3 Homo sapiens 700 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105521 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105521&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808219 174007832 ZINC96176391 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224100 COc1ccc(cc1)C(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1nc(C)no1)c1ccccc1OC InChI=1S/C28H23N3O6/c1-16-29-27(37-30-16)18-8-12-19(13-9-18)31-24(21-6-4-5-7-22(21)36-3)23(26(33)28(31)34)25(32)17-10-14-20(35-2)15-11-17/h4-15,23-24H,1-3H3 KIXSEVQCAAUYQM-UHFFFAOYSA-N 105522 US8575197, I-032 P2X purinoceptor 3 Homo sapiens 160 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105522 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105522&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808220 174007833 ZINC96176392 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224101 COc1ccc(cc1)C(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1nnc(C)o1)c1ccccc1OC InChI=1S/C28H23N3O6/c1-16-29-30-27(37-16)18-8-12-19(13-9-18)31-24(21-6-4-5-7-22(21)36-3)23(26(33)28(31)34)25(32)17-10-14-20(35-2)15-11-17/h4-15,23-24H,1-3H3 DJMIAGLOFZCBFJ-UHFFFAOYSA-N 105523 US8575197, I-033 P2X purinoceptor 3 Homo sapiens 53 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105523 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105523&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808221 174007834 ZINC96176393 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224102 COc1ccc(cc1)C(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1cccnc1)c1ccccc1OC InChI=1S/C30H24N2O5/c1-36-23-15-11-20(12-16-23)28(33)26-27(24-7-3-4-8-25(24)37-2)32(30(35)29(26)34)22-13-9-19(10-14-22)21-6-5-17-31-18-21/h3-18,26-27H,1-2H3 HYGMRXBNVZEGNS-UHFFFAOYSA-N 105524 US8575197, I-034 P2X purinoceptor 3 Homo sapiens 700 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105524 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105524&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808222 174007835 ZINC96176394 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224103 COc1ccccc1C1C(C(=O)C(C)(C)C)C(=O)C(=O)N1c1ccc(cc1)C(C)C InChI=1S/C25H29NO4/c1-15(2)16-11-13-17(14-12-16)26-21(18-9-7-8-10-19(18)30-6)20(22(27)24(26)29)23(28)25(3,4)5/h7-15,20-21H,1-6H3 JTNUDEAZOXGMDZ-UHFFFAOYSA-N 105527 US8575197, I-037 P2X purinoceptor 3 Homo sapiens 954 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105527 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105527&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808223 174007838 ZINC96176397 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224104 COc1ccc2sc(nc2c1)N1C(C(C(=O)C(C)(C)C)C(=O)C1=O)c1ccccc1OC InChI=1S/C24H24N2O5S/c1-24(2,3)21(28)18-19(14-8-6-7-9-16(14)31-5)26(22(29)20(18)27)23-25-15-12-13(30-4)10-11-17(15)32-23/h6-12,18-19H,1-5H3 YNAIYBFLAHWADJ-UHFFFAOYSA-N 105528 US8575197, I-038 P2X purinoceptor 3 Homo sapiens 926 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105528 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105528&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808224 174007839 ZINC96176398 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224105 COc1ccc(cc1)C(=O)C1C(C2CCCCC2)N(C(=O)C1=O)c1ccc(cc1)-c1ccoc1 InChI=1S/C28H27NO5/c1-33-23-13-9-20(10-14-23)26(30)24-25(19-5-3-2-4-6-19)29(28(32)27(24)31)22-11-7-18(8-12-22)21-15-16-34-17-21/h7-17,19,24-25H,2-6H2,1H3 PBRYAQPYDIKDKV-UHFFFAOYSA-N 105529 US8575197, I-039 P2X purinoceptor 3 Homo sapiens 12 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105529 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105529&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808225 174007840 ZINC96176399 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224106 CCCc1ccc(cc1)N1C(C(C(=O)C(C)(C)C)C(=O)C1=O)c1ccccc1OC InChI=1S/C25H29NO4/c1-6-9-16-12-14-17(15-13-16)26-21(18-10-7-8-11-19(18)30-5)20(22(27)24(26)29)23(28)25(2,3)4/h7-8,10-15,20-21H,6,9H2,1-5H3 ODTPWOCZVCYFMI-UHFFFAOYSA-N 105534 US8575197, I-044 P2X purinoceptor 3 Homo sapiens 468 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105534 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105534&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808226 174007845 ZINC96176404 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224107 COc1ccccc1C1C(C(=O)C(C)(C)C)C(=O)C(=O)N1c1ccc(cc1)C(C)(C)C InChI=1S/C26H31NO4/c1-25(2,3)16-12-14-17(15-13-16)27-21(18-10-8-9-11-19(18)31-7)20(22(28)24(27)30)23(29)26(4,5)6/h8-15,20-21H,1-7H3 SZWWTIDHPCRSNF-UHFFFAOYSA-N 105536 US8575197, I-046 P2X purinoceptor 3 Homo sapiens 580 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105536 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105536&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808227 174007847 ZINC96176406 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224108 COc1ccccc1C1C(C(=O)C(C)(C)C)C(=O)C(=O)N1c1ccc(SC(F)(F)F)cc1 InChI=1S/C23H22F3NO4S/c1-22(2,3)20(29)17-18(15-7-5-6-8-16(15)31-4)27(21(30)19(17)28)13-9-11-14(12-10-13)32-23(24,25)26/h5-12,17-18H,1-4H3 WQRARCQQTXVKQD-UHFFFAOYSA-N 105537 US8575197, I-047 P2X purinoceptor 3 Homo sapiens 221 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105537 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105537&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808228 174007848 ZINC96176407 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224109 COc1ccccc1C1C(C(=O)C(C)(C)C)C(=O)C(=O)N1c1ccc(cc1)C(F)(F)F InChI=1S/C23H22F3NO4/c1-22(2,3)20(29)17-18(15-7-5-6-8-16(15)31-4)27(21(30)19(17)28)14-11-9-13(10-12-14)23(24,25)26/h5-12,17-18H,1-4H3 XUWWBHLMWPQBJJ-UHFFFAOYSA-N 105538 US8575197, I-048 P2X purinoceptor 3 Homo sapiens 752 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105538 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105538&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808229 174007849 ZINC96176408 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224110 COCc1ccccc1C1C(C(=O)C(C)(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1cc(C)no1 InChI=1S/C27H28N2O5/c1-16-14-21(34-28-16)17-10-12-19(13-11-17)29-23(20-9-7-6-8-18(20)15-33-5)22(24(30)26(29)32)25(31)27(2,3)4/h6-14,22-23H,15H2,1-5H3 ZXHVYLALSHYKMP-UHFFFAOYSA-N 105540 US8575197, I-050 P2X purinoceptor 3 Homo sapiens 642 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105540 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105540&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808230 174007851 ZINC96176410 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224111 COCc1ccccc1C1C(C(=O)C(C)(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1noc(C)n1 InChI=1S/C26H27N3O5/c1-15-27-24(28-34-15)16-10-12-18(13-11-16)29-21(19-9-7-6-8-17(19)14-33-5)20(22(30)25(29)32)23(31)26(2,3)4/h6-13,20-21H,14H2,1-5H3 OCDRKXTXDXJQBX-UHFFFAOYSA-N 105541 US8575197, I-051 P2X purinoceptor 3 Homo sapiens 277 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105541 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105541&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808231 174007852 ZINC96176411 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224112 COc1ccccc1C1C(C(=O)C(C)(C)C)C(=O)C(=O)N1c1ccc(SC)cc1 InChI=1S/C23H25NO4S/c1-23(2,3)21(26)18-19(16-8-6-7-9-17(16)28-4)24(22(27)20(18)25)14-10-12-15(29-5)13-11-14/h6-13,18-19H,1-5H3 JVBFQJWVXHSZFN-UHFFFAOYSA-N 105542 US8575197, I-052 P2X purinoceptor 3 Homo sapiens 187 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105542 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105542&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808232 174007853 ZINC96176412 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224113 CC(C)(C)C(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1ccon1)c1cccc2OCOc12 InChI=1S/C25H22N2O6/c1-25(2,3)23(29)19-20(16-5-4-6-18-22(16)32-13-31-18)27(24(30)21(19)28)15-9-7-14(8-10-15)17-11-12-33-26-17/h4-12,19-20H,13H2,1-3H3 YWSWDBZWSQIFNV-UHFFFAOYSA-N 105545 US8575197, I-055 P2X purinoceptor 3 Homo sapiens 596 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105545 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105545&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808233 174007856 ZINC96176415 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224114 CSc1ccccc1C1C(C(=O)C(C)(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccon1 InChI=1S/C25H24N2O4S/c1-25(2,3)23(29)20-21(17-7-5-6-8-19(17)32-4)27(24(30)22(20)28)16-11-9-15(10-12-16)18-13-14-31-26-18/h5-14,20-21H,1-4H3 IXABOACWKQLJSD-UHFFFAOYSA-N 105547 US8575197, I-057 P2X purinoceptor 3 Homo sapiens 159 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105547 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105547&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808234 174007858 ZINC96176417 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224115 CC(C)(C)C(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1ccon1)c1ccccc1OCCO InChI=1S/C26H26N2O6/c1-26(2,3)24(31)21-22(18-6-4-5-7-20(18)33-15-13-29)28(25(32)23(21)30)17-10-8-16(9-11-17)19-12-14-34-27-19/h4-12,14,21-22,29H,13,15H2,1-3H3 ZRLMXFBWVIYVAC-UHFFFAOYSA-N 105548 US8575197, I-058 P2X purinoceptor 3 Homo sapiens 82 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105548 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105548&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808235 174007859 ZINC96176418 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224116 CCOc1ccccc1C1C(C(=O)C(C)(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccon1 InChI=1S/C26H26N2O5/c1-5-32-20-9-7-6-8-18(20)22-21(24(30)26(2,3)4)23(29)25(31)28(22)17-12-10-16(11-13-17)19-14-15-33-27-19/h6-15,21-22H,5H2,1-4H3 FGVLJAQVFYZUDP-UHFFFAOYSA-N 105549 US8575197, I-059 P2X purinoceptor 3 Homo sapiens 260 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105549 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105549&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808236 174007860 ZINC96176419 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224117 CC(C)(C)C(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1ccon1)c1ccccc1OC(F)F InChI=1S/C25H22F2N2O5/c1-25(2,3)22(31)19-20(16-6-4-5-7-18(16)34-24(26)27)29(23(32)21(19)30)15-10-8-14(9-11-15)17-12-13-33-28-17/h4-13,19-20,24H,1-3H3 PUPOXPGISMEVTO-UHFFFAOYSA-N 105554 US8575197, I-064 P2X purinoceptor 3 Homo sapiens 137 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105554 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105554&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808237 174007865 ZINC96176424 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224118 COc1ncccc1C1C(C(=O)C(C)(C)C)C(=O)C(=O)N1c1ccc(SC)cc1 InChI=1S/C22H24N2O4S/c1-22(2,3)19(26)16-17(15-7-6-12-23-20(15)28-4)24(21(27)18(16)25)13-8-10-14(29-5)11-9-13/h6-12,16-17H,1-5H3 FOVHZEYFEFEMLU-UHFFFAOYSA-N 105556 US8575197, I-066 P2X purinoceptor 3 Homo sapiens 434 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105556 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105556&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808238 174007867 ZINC96176426 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224119 COc1ccccc1C1C(C(=O)C(C)(C)CO)C(=O)C(=O)N1c1ccc(SC)cc1 InChI=1S/C23H25NO5S/c1-23(2,13-25)21(27)18-19(16-7-5-6-8-17(16)29-3)24(22(28)20(18)26)14-9-11-15(30-4)12-10-14/h5-12,18-19,25H,13H2,1-4H3 MYWMQEBETXCPSE-UHFFFAOYSA-N 105558 US8575197, I-068 P2X purinoceptor 3 Homo sapiens 305 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105558 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105558&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808239 174007869 ZINC96176428 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224120 CN(C)c1ccccc1C1C(C(=O)C(C)(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccon1 InChI=1S/C26H27N3O4/c1-26(2,3)24(31)21-22(18-8-6-7-9-20(18)28(4)5)29(25(32)23(21)30)17-12-10-16(11-13-17)19-14-15-33-27-19/h6-15,21-22H,1-5H3 CSCQYKSWRGHIBK-UHFFFAOYSA-N 105560 US8575197, I-070 P2X purinoceptor 3 Homo sapiens 519 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105560 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105560&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808240 174007871 ZINC96176430 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224121 COc1ccccc1C1C(C(=O)CC(C)(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccon1 InChI=1S/C26H26N2O5/c1-26(2,3)15-20(29)22-23(18-7-5-6-8-21(18)32-4)28(25(31)24(22)30)17-11-9-16(10-12-17)19-13-14-33-27-19/h5-14,22-23H,15H2,1-4H3 XCMNERNWDVDWIX-UHFFFAOYSA-N 105562 US8575197, I-072 P2X purinoceptor 3 Homo sapiens 352 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105562 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105562&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808241 174007873 ZINC96176432 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224122 CC(C)(C)C(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1ccsc1)c1ccccc1OCCO InChI=1S/C27H27NO5S/c1-27(2,3)25(31)22-23(20-6-4-5-7-21(20)33-14-13-29)28(26(32)24(22)30)19-10-8-17(9-11-19)18-12-15-34-16-18/h4-12,15-16,22-23,29H,13-14H2,1-3H3 UYHZJWBZHLZLFQ-UHFFFAOYSA-N 105565 US8575197, I-075 P2X purinoceptor 3 Homo sapiens 13 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105565 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105565&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808242 174007876 ZINC96176435 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224123 COc1ccccc1C1C(C(=O)C(C)(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccoc1 InChI=1S/C26H25NO5/c1-26(2,3)24(29)21-22(19-7-5-6-8-20(19)31-4)27(25(30)23(21)28)18-11-9-16(10-12-18)17-13-14-32-15-17/h5-15,21-22H,1-4H3 VHKPIPAKRFLIBJ-UHFFFAOYSA-N 105567 US8575197, I-077 P2X purinoceptor 3 Homo sapiens 48 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105567 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105567&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808243 174007878 ZINC96176437 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224124 COc1ccccc1C1C(C(=O)C(C)(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccsc1 InChI=1S/C26H25NO4S/c1-26(2,3)24(29)21-22(19-7-5-6-8-20(19)31-4)27(25(30)23(21)28)18-11-9-16(10-12-18)17-13-14-32-15-17/h5-15,21-22H,1-4H3 ONPOYOVKOBUGTR-UHFFFAOYSA-N 105568 US8575197, I-078 P2X purinoceptor 3 Homo sapiens 16 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105568 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105568&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808244 174007879 ZINC96176438 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224125 CC(C)C(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1ccco1)c1ccccc1OCCO InChI=1S/C26H25NO6/c1-16(2)24(29)22-23(19-6-3-4-7-21(19)33-15-13-28)27(26(31)25(22)30)18-11-9-17(10-12-18)20-8-5-14-32-20/h3-12,14,16,22-23,28H,13,15H2,1-2H3 GNYSVKCVQFKSEQ-UHFFFAOYSA-N 105715 US8575197, I-225 P2X purinoceptor 3 Homo sapiens 65 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105715 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105715&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808362 174008026 ZINC96176579 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224126 COCCOc1ccccc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1cccs1 InChI=1S/C27H27NO5S/c1-17(2)25(29)23-24(20-7-4-5-8-21(20)33-15-14-32-3)28(27(31)26(23)30)19-12-10-18(11-13-19)22-9-6-16-34-22/h4-13,16-17,23-24H,14-15H2,1-3H3 BGFJDCRXWCCDIW-UHFFFAOYSA-N 105716 US8575197, I-226 P2X purinoceptor 3 Homo sapiens 12 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105716 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105716&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808363 174008027 ZINC96176580 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224127 COCOc1ccccc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1cccs1 InChI=1S/C26H25NO5S/c1-16(2)24(28)22-23(19-7-4-5-8-20(19)32-15-31-3)27(26(30)25(22)29)18-12-10-17(11-13-18)21-9-6-14-33-21/h4-14,16,22-23H,15H2,1-3H3 AENGQZHQZJXESW-UHFFFAOYSA-N 105717 US8575197, I-227 P2X purinoceptor 3 Homo sapiens 8 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105717 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105717&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808364 174008028 ZINC96176581 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224128 COCCOc1ncccc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1cccs1 InChI=1S/C26H26N2O5S/c1-16(2)23(29)21-22(19-6-4-12-27-25(19)33-14-13-32-3)28(26(31)24(21)30)18-10-8-17(9-11-18)20-7-5-15-34-20/h4-12,15-16,21-22H,13-14H2,1-3H3 RMFVNSWZXMIFOT-UHFFFAOYSA-N 105718 US8575197, I-228 P2X purinoceptor 3 Homo sapiens 15 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105718 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105718&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808365 174008029 ZINC96176582 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224129 CC(C)C(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1cccs1)c1cccnc1OCCO InChI=1S/C25H24N2O5S/c1-15(2)22(29)20-21(18-5-3-11-26-24(18)32-13-12-28)27(25(31)23(20)30)17-9-7-16(8-10-17)19-6-4-14-33-19/h3-11,14-15,20-21,28H,12-13H2,1-2H3 HQKQOHXFHFXYDS-UHFFFAOYSA-N 105719 US8575197, I-229 P2X purinoceptor 3 Homo sapiens 29 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105719 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105719&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808366 174008030 ZINC96176583 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224130 COCOc1ccccc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccco1 InChI=1S/C26H25NO6/c1-16(2)24(28)22-23(19-7-4-5-8-21(19)33-15-31-3)27(26(30)25(22)29)18-12-10-17(11-13-18)20-9-6-14-32-20/h4-14,16,22-23H,15H2,1-3H3 UEWYIKYGYQYLLZ-UHFFFAOYSA-N 105720 US8575197, I-230 P2X purinoceptor 3 Homo sapiens 18 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105720 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105720&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808367 174008031 ZINC96176584 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224131 COCCOc1ccccc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccco1 InChI=1S/C27H27NO6/c1-17(2)25(29)23-24(20-7-4-5-8-22(20)34-16-15-32-3)28(27(31)26(23)30)19-12-10-18(11-13-19)21-9-6-14-33-21/h4-14,17,23-24H,15-16H2,1-3H3 PLUXKLCJBWWQTI-UHFFFAOYSA-N 105721 US8575197, I-231 P2X purinoceptor 3 Homo sapiens 23 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105721 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105721&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808368 174008032 ZINC96176585 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224132 COCOc1ccccc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccoc1 InChI=1S/C26H25NO6/c1-16(2)24(28)22-23(20-6-4-5-7-21(20)33-15-31-3)27(26(30)25(22)29)19-10-8-17(9-11-19)18-12-13-32-14-18/h4-14,16,22-23H,15H2,1-3H3 WQYCSZMNJHLTPM-UHFFFAOYSA-N 105722 US8575197, I-232 P2X purinoceptor 3 Homo sapiens 24 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105722 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105722&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808369 174008033 ZINC96176586 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224133 CC(C)C(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1ccoc1)c1cccnc1OCCO InChI=1S/C25H24N2O6/c1-15(2)22(29)20-21(19-4-3-10-26-24(19)33-13-11-28)27(25(31)23(20)30)18-7-5-16(6-8-18)17-9-12-32-14-17/h3-10,12,14-15,20-21,28H,11,13H2,1-2H3 MPJILDFSNYSRNN-UHFFFAOYSA-N 105723 US8575197, I-233 P2X purinoceptor 3 Homo sapiens 124 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105723 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105723&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808370 174008034 ZINC96176587 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224134 COCCOc1ncccc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccoc1 InChI=1S/C26H26N2O6/c1-16(2)23(29)21-22(20-5-4-11-27-25(20)34-14-13-32-3)28(26(31)24(21)30)19-8-6-17(7-9-19)18-10-12-33-15-18/h4-12,15-16,21-22H,13-14H2,1-3H3 NGQRNTBXPXURAE-UHFFFAOYSA-N 105724 US8575197, I-234 P2X purinoceptor 3 Homo sapiens 56 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105724 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105724&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808371 174008035 ZINC96176588 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224135 COc1ccccc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(-c2ccsc2)c(F)c1 InChI=1S/C25H22FNO4S/c1-14(2)23(28)21-22(18-6-4-5-7-20(18)31-3)27(25(30)24(21)29)16-8-9-17(19(26)12-16)15-10-11-32-13-15/h4-14,21-22H,1-3H3 XMYNOMBEZAEOSY-UHFFFAOYSA-N 105725 US8575197, I-235 P2X purinoceptor 3 Homo sapiens 35 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105725 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105725&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808372 174008036 ZINC96176589 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224136 COc1ccccc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(-c2ccsc2)c(C)c1 InChI=1S/C26H25NO4S/c1-15(2)24(28)22-23(20-7-5-6-8-21(20)31-4)27(26(30)25(22)29)18-9-10-19(16(3)13-18)17-11-12-32-14-17/h5-15,22-23H,1-4H3 KTGGRPKQLMKRDZ-UHFFFAOYSA-N 105726 US8575197, I-236 P2X purinoceptor 3 Homo sapiens 431 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105726 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105726&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808373 174008037 ZINC96176590 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224137 COc1ccccc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(-c2ccsc2)c(N)c1 InChI=1S/C25H24N2O4S/c1-14(2)23(28)21-22(18-6-4-5-7-20(18)31-3)27(25(30)24(21)29)16-8-9-17(19(26)12-16)15-10-11-32-13-15/h4-14,21-22H,26H2,1-3H3 BADDLPDXFCFUNQ-UHFFFAOYSA-N 105727 US8575197, I-237 P2X purinoceptor 3 Homo sapiens 705 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105727 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105727&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808374 174008038 ZINC96176591 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224138 COc1ccccc1C1C(C(=O)CC(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccsc1 InChI=1S/C26H25NO4S/c1-16(2)14-21(28)23-24(20-6-4-5-7-22(20)31-3)27(26(30)25(23)29)19-10-8-17(9-11-19)18-12-13-32-15-18/h4-13,15-16,23-24H,14H2,1-3H3 QYDKUBONZZJGAP-UHFFFAOYSA-N 105729 US8575197, I-239 P2X purinoceptor 3 Homo sapiens 35 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105729 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105729&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808375 174008040 ZINC96176593 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224139 COc1ccccc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(-c2ccsc2)c(O)c1 InChI=1S/C25H23NO5S/c1-14(2)23(28)21-22(18-6-4-5-7-20(18)31-3)26(25(30)24(21)29)16-8-9-17(19(27)12-16)15-10-11-32-13-15/h4-14,21-22,27H,1-3H3 QNHDLMLTZDUTKP-UHFFFAOYSA-N 105730 US8575197, I-240 P2X purinoceptor 3 Homo sapiens 185 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105730 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105730&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808376 174008041 ZINC96176594 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224140 COc1ccccc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(-c2ccsc2)c(CO)c1 InChI=1S/C26H25NO5S/c1-15(2)24(29)22-23(20-6-4-5-7-21(20)32-3)27(26(31)25(22)30)18-8-9-19(17(12-18)13-28)16-10-11-33-14-16/h4-12,14-15,22-23,28H,13H2,1-3H3 DZCFAKASKUVUQS-UHFFFAOYSA-N 105731 US8575197, I-241 P2X purinoceptor 3 Homo sapiens 822 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105731 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105731&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808377 174008042 ZINC96176595 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224141 COc1ccccc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(-c2ccsc2)c(c1)N(C)C InChI=1S/C27H28N2O4S/c1-16(2)25(30)23-24(20-8-6-7-9-22(20)33-5)29(27(32)26(23)31)18-10-11-19(17-12-13-34-15-17)21(14-18)28(3)4/h6-16,23-24H,1-5H3 JVCDTEMQGMMZLQ-UHFFFAOYSA-N 105732 US8575197, I-242 P2X purinoceptor 3 Homo sapiens 357 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105732 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105732&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808378 174008043 ZINC96176596 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224142 CC(C)C(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1ccsc1)c1ccccc1C#N InChI=1S/C25H20N2O3S/c1-15(2)23(28)21-22(20-6-4-3-5-17(20)13-26)27(25(30)24(21)29)19-9-7-16(8-10-19)18-11-12-31-14-18/h3-12,14-15,21-22H,1-2H3 SZDMFRRZRDGLLX-UHFFFAOYSA-N 105734 US8575197, I-244 P2X purinoceptor 3 Homo sapiens 27 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105734 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105734&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808379 174008045 ZINC96176598 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224143 CC(C)C(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1ccsc1)c1ccccc1C(=O)N(C)C InChI=1S/C27H26N2O4S/c1-16(2)24(30)22-23(20-7-5-6-8-21(20)26(32)28(3)4)29(27(33)25(22)31)19-11-9-17(10-12-19)18-13-14-34-15-18/h5-16,22-23H,1-4H3 JYTSUBUYJDFHCX-UHFFFAOYSA-N 105735 US8575197, I-245 P2X purinoceptor 3 Homo sapiens 47 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105735 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105735&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808380 174008046 ZINC96176599 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224144 COCCc1ccccc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccsc1 InChI=1S/C27H27NO4S/c1-17(2)25(29)23-24(22-7-5-4-6-19(22)12-14-32-3)28(27(31)26(23)30)21-10-8-18(9-11-21)20-13-15-33-16-20/h4-11,13,15-17,23-24H,12,14H2,1-3H3 SOHJIDUWHSRCFW-UHFFFAOYSA-N 105737 US8575197, I-247 P2X purinoceptor 3 Homo sapiens 15 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105737 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105737&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808381 174008048 ZINC96176601 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224145 COCCOc1ncccc1C1C(C(=O)CC(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccsc1 InChI=1S/C27H28N2O5S/c1-17(2)15-22(30)23-24(21-5-4-11-28-26(21)34-13-12-33-3)29(27(32)25(23)31)20-8-6-18(7-9-20)19-10-14-35-16-19/h4-11,14,16-17,23-24H,12-13,15H2,1-3H3 RDANHEFVCJWVTR-UHFFFAOYSA-N 105738 US8575197, I-248 P2X purinoceptor 3 Homo sapiens 30 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105738 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105738&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808382 174008049 ZINC96176602 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224146 COCOc1ccccc1C1C(C(=O)CC(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccsc1 InChI=1S/C27H27NO5S/c1-17(2)14-22(29)24-25(21-6-4-5-7-23(21)33-16-32-3)28(27(31)26(24)30)20-10-8-18(9-11-20)19-12-13-34-15-19/h4-13,15,17,24-25H,14,16H2,1-3H3 AOKMEXPCJUCDFG-UHFFFAOYSA-N 105739 US8575197, I-249 P2X purinoceptor 3 Homo sapiens 10 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105739 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105739&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808383 174008050 ZINC96176603 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224147 CC(C)CC(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1ccsc1)c1ccccc1OCCO InChI=1S/C27H27NO5S/c1-17(2)15-22(30)24-25(21-5-3-4-6-23(21)33-13-12-29)28(27(32)26(24)31)20-9-7-18(8-10-20)19-11-14-34-16-19/h3-11,14,16-17,24-25,29H,12-13,15H2,1-2H3 PKCYVCPQLZYCSW-UHFFFAOYSA-N 105740 US8575197, I-250 P2X purinoceptor 3 Homo sapiens 29 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105740 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105740&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808384 174008051 ZINC96176604 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224148 COCCOc1ccccc1C1C(C(=O)CC(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccsc1 InChI=1S/C28H29NO5S/c1-18(2)16-23(30)25-26(22-6-4-5-7-24(22)34-14-13-33-3)29(28(32)27(25)31)21-10-8-19(9-11-21)20-12-15-35-17-20/h4-12,15,17-18,25-26H,13-14,16H2,1-3H3 LEYYWHQDHUHWIO-UHFFFAOYSA-N 105741 US8575197, I-251 P2X purinoceptor 3 Homo sapiens 17 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105741 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105741&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808385 174008052 ZINC96176605 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224149 COCc1ccccc1C1C(C(=O)CC(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccsc1 InChI=1S/C27H27NO4S/c1-17(2)14-23(29)24-25(22-7-5-4-6-19(22)15-32-3)28(27(31)26(24)30)21-10-8-18(9-11-21)20-12-13-33-16-20/h4-13,16-17,24-25H,14-15H2,1-3H3 ACJAHHCOANCIQB-UHFFFAOYSA-N 105742 US8575197, I-252 P2X purinoceptor 3 Homo sapiens 10 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105742 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105742&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808386 174008053 ZINC96176606 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224150 CNC(C(C)C)=C1C(N(C(=O)C1=O)c1ccc(cc1)-c1ccsc1)c1ccc[nH]c1=O InChI=1S/C24H23N3O3S/c1-14(2)20(25-3)19-21(18-5-4-11-26-23(18)29)27(24(30)22(19)28)17-8-6-15(7-9-17)16-10-12-31-13-16/h4-14,21,25H,1-3H3,(H,26,29) FKGCQWVQFNOEJO-UHFFFAOYSA-N 105743 US8575197, I-253 P2X purinoceptor 3 Homo sapiens 193 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105743 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105743&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808387 174008054 ZINC96176607 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224151 COCc1ccccc1[C@H]1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccsc1 InChI=1S/C26H25NO4S/c1-16(2)24(28)22-23(21-7-5-4-6-18(21)14-31-3)27(26(30)25(22)29)20-10-8-17(9-11-20)19-12-13-32-15-19/h4-13,15-16,22-23H,14H2,1-3H3/t22?,23-/m0/s1 WZEWWSYBFASMGA-WCSIJFPASA-N 105744 US8575197, I-254 P2X purinoceptor 3 Homo sapiens 511 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105744 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105744&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808388 174008055 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224152 COCc1ccccc1[C@@H]1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccsc1 InChI=1S/C26H25NO4S/c1-16(2)24(28)22-23(21-7-5-4-6-18(21)14-31-3)27(26(30)25(22)29)20-10-8-17(9-11-20)19-12-13-32-15-19/h4-13,15-16,22-23H,14H2,1-3H3/t22?,23-/m1/s1 WZEWWSYBFASMGA-OZAIVSQSSA-N 105745 US8575197, I-255 P2X purinoceptor 3 Homo sapiens 8 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105745 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105745&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808389 174008056 ZINC96176608 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224153 CC(C)C(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1csc(C)c1)c1ccccc1OCCO InChI=1S/C27H27NO5S/c1-16(2)25(30)23-24(21-6-4-5-7-22(21)33-13-12-29)28(27(32)26(23)31)20-10-8-18(9-11-20)19-14-17(3)34-15-19/h4-11,14-16,23-24,29H,12-13H2,1-3H3 DJSMZYNCBRZCDS-UHFFFAOYSA-N 105746 US8575197, I-256 P2X purinoceptor 3 Homo sapiens 23 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105746 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105746&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808390 174008057 ZINC96176609 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224154 COc1ccccc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1csc(C)c1 InChI=1S/C26H25NO4S/c1-15(2)24(28)22-23(20-7-5-6-8-21(20)31-4)27(26(30)25(22)29)19-11-9-17(10-12-19)18-13-16(3)32-14-18/h5-15,22-23H,1-4H3 CQYHDKFNIFHGOD-UHFFFAOYSA-N 105747 US8575197, I-257 P2X purinoceptor 3 Homo sapiens 37 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105747 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105747&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808391 174008058 ZINC96176610 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224155 CC(C)C(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1ccc(C)s1)c1ccccc1OCCO InChI=1S/C27H27NO5S/c1-16(2)25(30)23-24(20-6-4-5-7-21(20)33-15-14-29)28(27(32)26(23)31)19-11-9-18(10-12-19)22-13-8-17(3)34-22/h4-13,16,23-24,29H,14-15H2,1-3H3 RILDIIWENFCDDH-UHFFFAOYSA-N 105748 US8575197, I-258 P2X purinoceptor 3 Homo sapiens 24 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105748 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105748&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808392 174008059 ZINC96176611 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224156 COc1ccccc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccc(C)s1 InChI=1S/C26H25NO4S/c1-15(2)24(28)22-23(19-7-5-6-8-20(19)31-4)27(26(30)25(22)29)18-12-10-17(11-13-18)21-14-9-16(3)32-21/h5-15,22-23H,1-4H3 PRPFLIWKSDTARP-UHFFFAOYSA-N 105749 US8575197, I-259 P2X purinoceptor 3 Homo sapiens 30 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105749 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105749&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808393 174008060 ZINC96176612 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224157 CC(C)C(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1ccsc1)c1cccnc1Cl InChI=1S/C23H19ClN2O3S/c1-13(2)20(27)18-19(17-4-3-10-25-22(17)24)26(23(29)21(18)28)16-7-5-14(6-8-16)15-9-11-30-12-15/h3-13,18-19H,1-2H3 NTSDKOUHWRNOTR-UHFFFAOYSA-N 105750 US8575197, I-260 P2X purinoceptor 3 Homo sapiens 331 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105750 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105750&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808394 174008061 ZINC96176613 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224158 COCCOc1ccccc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1csc(C)c1 InChI=1S/C28H29NO5S/c1-17(2)26(30)24-25(22-7-5-6-8-23(22)34-14-13-33-4)29(28(32)27(24)31)21-11-9-19(10-12-21)20-15-18(3)35-16-20/h5-12,15-17,24-25H,13-14H2,1-4H3 DCCGJJCZANZDDX-UHFFFAOYSA-N 105751 US8575197, I-261 P2X purinoceptor 3 Homo sapiens 19 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105751 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105751&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808395 174008062 ZINC96176614 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224159 COCOc1ccccc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1csc(C)c1 InChI=1S/C27H27NO5S/c1-16(2)25(29)23-24(21-7-5-6-8-22(21)33-15-32-4)28(27(31)26(23)30)20-11-9-18(10-12-20)19-13-17(3)34-14-19/h5-14,16,23-24H,15H2,1-4H3 CRVYULYXUIGIRL-UHFFFAOYSA-N 105752 US8575197, I-262 P2X purinoceptor 3 Homo sapiens 16 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105752 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105752&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808396 174008063 ZINC96176615 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224160 COCCOc1ccccc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccc(C)s1 InChI=1S/C28H29NO5S/c1-17(2)26(30)24-25(21-7-5-6-8-22(21)34-16-15-33-4)29(28(32)27(24)31)20-12-10-19(11-13-20)23-14-9-18(3)35-23/h5-14,17,24-25H,15-16H2,1-4H3 MJLQIYJLZJBNBG-UHFFFAOYSA-N 105753 US8575197, I-263 P2X purinoceptor 3 Homo sapiens 8 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105753 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105753&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808397 174008064 ZINC96176616 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224161 COCOc1ccccc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccc(C)s1 InChI=1S/C27H27NO5S/c1-16(2)25(29)23-24(20-7-5-6-8-21(20)33-15-32-4)28(27(31)26(23)30)19-12-10-18(11-13-19)22-14-9-17(3)34-22/h5-14,16,23-24H,15H2,1-4H3 GUQCQIPKTJDPNA-UHFFFAOYSA-N 105754 US8575197, I-264 P2X purinoceptor 3 Homo sapiens 14 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105754 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105754&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808398 174008065 ZINC96176617 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224162 COCc1ccccc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1csc(C)c1 InChI=1S/C27H27NO4S/c1-16(2)25(29)23-24(22-8-6-5-7-19(22)14-32-4)28(27(31)26(23)30)21-11-9-18(10-12-21)20-13-17(3)33-15-20/h5-13,15-16,23-24H,14H2,1-4H3 QCJAWEIJBAFKJA-UHFFFAOYSA-N 105755 US8575197, I-265 P2X purinoceptor 3 Homo sapiens 28 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105755 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105755&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808399 174008066 ZINC96176618 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224163 COCc1ccccc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccc(C)s1 InChI=1S/C27H27NO4S/c1-16(2)25(29)23-24(21-8-6-5-7-19(21)15-32-4)28(27(31)26(23)30)20-12-10-18(11-13-20)22-14-9-17(3)33-22/h5-14,16,23-24H,15H2,1-4H3 BYRMHEMRSOPNRI-UHFFFAOYSA-N 105756 US8575197, I-266 P2X purinoceptor 3 Homo sapiens 25 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105756 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105756&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808400 174008067 ZINC96176619 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224164 COCCOc1ncccc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccc(C)s1 InChI=1S/C27H28N2O5S/c1-16(2)24(30)22-23(20-6-5-13-28-26(20)34-15-14-33-4)29(27(32)25(22)31)19-10-8-18(9-11-19)21-12-7-17(3)35-21/h5-13,16,22-23H,14-15H2,1-4H3 QIXPGMREOHTNEW-UHFFFAOYSA-N 105757 US8575197, I-267 P2X purinoceptor 3 Homo sapiens 14 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105757 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105757&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808401 174008068 ZINC96176620 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224165 COCCOc1ncccc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1csc(C)c1 InChI=1S/C27H28N2O5S/c1-16(2)24(30)22-23(21-6-5-11-28-26(21)34-13-12-33-4)29(27(32)25(22)31)20-9-7-18(8-10-20)19-14-17(3)35-15-19/h5-11,14-16,22-23H,12-13H2,1-4H3 WUTNHXSNUCPUJD-UHFFFAOYSA-N 105758 US8575197, I-268 P2X purinoceptor 3 Homo sapiens 32 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105758 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105758&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808402 174008069 ZINC96176621 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224166 COc1ccccc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc2sccc2c1 InChI=1S/C23H21NO4S/c1-13(2)21(25)19-20(16-6-4-5-7-17(16)28-3)24(23(27)22(19)26)15-8-9-18-14(12-15)10-11-29-18/h4-13,19-20H,1-3H3 WXLKBHGQJVVUQB-UHFFFAOYSA-N 105759 US8575197, I-269 P2X purinoceptor 3 Homo sapiens 347 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105759 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105759&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808403 174008070 ZINC96176622 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224167 COCCOc1ccccc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1nc(C)no1 InChI=1S/C26H27N3O6/c1-15(2)23(30)21-22(19-7-5-6-8-20(19)34-14-13-33-4)29(26(32)24(21)31)18-11-9-17(10-12-18)25-27-16(3)28-35-25/h5-12,15,21-22H,13-14H2,1-4H3 OUPOYMKHCZTLMC-UHFFFAOYSA-N 105761 US8575197, I-271 P2X purinoceptor 3 Homo sapiens 542 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105761 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105761&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808404 174008072 ZINC96176624 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224168 COCCOc1ccccc1C1C(C(=O)CC(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1nc(C)no1 InChI=1S/C27H29N3O6/c1-16(2)15-21(31)23-24(20-7-5-6-8-22(20)35-14-13-34-4)30(27(33)25(23)32)19-11-9-18(10-12-19)26-28-17(3)29-36-26/h5-12,16,23-24H,13-15H2,1-4H3 FJLRYXQRAOORHB-UHFFFAOYSA-N 105763 US8575197, I-273 P2X purinoceptor 3 Homo sapiens 491 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105763 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105763&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808405 174008074 ZINC96176626 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224169 COCCOc1ccccc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1noc(C)n1 InChI=1S/C26H27N3O6/c1-15(2)23(30)21-22(19-7-5-6-8-20(19)34-14-13-33-4)29(26(32)24(21)31)18-11-9-17(10-12-18)25-27-16(3)35-28-25/h5-12,15,21-22H,13-14H2,1-4H3 YJTJIPKOZASRDW-UHFFFAOYSA-N 105765 US8575197, I-275 P2X purinoceptor 3 Homo sapiens 172 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105765 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105765&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808406 174008076 ZINC96176628 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224170 COCCOc1ccccc1C1C(C(=O)CC(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1noc(C)n1 InChI=1S/C27H29N3O6/c1-16(2)15-21(31)23-24(20-7-5-6-8-22(20)35-14-13-34-4)30(27(33)25(23)32)19-11-9-18(10-12-19)26-28-17(3)36-29-26/h5-12,16,23-24H,13-15H2,1-4H3 ZNDBQPOMHLTOLM-UHFFFAOYSA-N 105766 US8575197, I-276 P2X purinoceptor 3 Homo sapiens 117 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105766 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105766&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808407 174008077 ZINC96176629 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224171 CC(C)C(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1noc(C)n1)c1ccccc1OCCO InChI=1S/C25H25N3O6/c1-14(2)22(30)20-21(18-6-4-5-7-19(18)33-13-12-29)28(25(32)23(20)31)17-10-8-16(9-11-17)24-26-15(3)34-27-24/h4-11,14,20-21,29H,12-13H2,1-3H3 UBYAYHAIOGZLSH-UHFFFAOYSA-N 105767 US8575197, I-227 P2X purinoceptor 3 Homo sapiens 342 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105767 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105767&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808408 174008078 ZINC96176630 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224172 CC(C)CC(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1noc(C)n1)c1ccccc1OCCO InChI=1S/C26H27N3O6/c1-15(2)14-20(31)22-23(19-6-4-5-7-21(19)34-13-12-30)29(26(33)24(22)32)18-10-8-17(9-11-18)25-27-16(3)35-28-25/h4-11,15,22-23,30H,12-14H2,1-3H3 JMKPOZKTQXTSHP-UHFFFAOYSA-N 105768 US8575197, I-278 P2X purinoceptor 3 Homo sapiens 366 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105768 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105768&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808409 174008079 ZINC96176631 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224173 COc1ccccc1[C@@H]1C(C(=O)CC(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccsc1 InChI=1S/C26H25NO4S/c1-16(2)14-21(28)23-24(20-6-4-5-7-22(20)31-3)27(26(30)25(23)29)19-10-8-17(9-11-19)18-12-13-32-15-18/h4-13,15-16,23-24H,14H2,1-3H3/t23?,24-/m1/s1 QYDKUBONZZJGAP-XMMISQBUSA-N 105769 US8575197, I-279 P2X purinoceptor 3 Homo sapiens 16 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105769 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105769&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808410 174008080 ZINC96176632 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224174 COc1ccccc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1cscn1 InChI=1S/C24H22N2O4S/c1-14(2)22(27)20-21(17-6-4-5-7-19(17)30-3)26(24(29)23(20)28)16-10-8-15(9-11-16)18-12-31-13-25-18/h4-14,20-21H,1-3H3 BCRXJTZFNGBVMI-UHFFFAOYSA-N 105906 US8575197, I-416 P2X purinoceptor 3 Homo sapiens 322 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105906 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105906&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808532 174008217 ZINC96176767 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224175 COCCOc1ccccc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1cscn1 InChI=1S/C26H26N2O5S/c1-16(2)24(29)22-23(19-6-4-5-7-21(19)33-13-12-32-3)28(26(31)25(22)30)18-10-8-17(9-11-18)20-14-34-15-27-20/h4-11,14-16,22-23H,12-13H2,1-3H3 GAEYDCLJIYMQRU-UHFFFAOYSA-N 105907 US8575197, I-417 P2X purinoceptor 3 Homo sapiens 181 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105907 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105907&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808533 174008218 ZINC96176768 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224176 COCc1ccccc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1cscn1 InChI=1S/C25H24N2O4S/c1-15(2)23(28)21-22(19-7-5-4-6-17(19)12-31-3)27(25(30)24(21)29)18-10-8-16(9-11-18)20-13-32-14-26-20/h4-11,13-15,21-22H,12H2,1-3H3 ASXCZCGWGYHYBW-UHFFFAOYSA-N 105908 US8575197, I-418 P2X purinoceptor 3 Homo sapiens 593 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105908 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105908&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808534 174008219 ZINC96176769 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224177 CC(C)Oc1ccccc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1csc(C)c1 InChI=1S/C28H29NO4S/c1-16(2)26(30)24-25(22-8-6-7-9-23(22)33-17(3)4)29(28(32)27(24)31)21-12-10-19(11-13-21)20-14-18(5)34-15-20/h6-17,24-25H,1-5H3 VCQRTADDQXZHAI-UHFFFAOYSA-N 105909 US8575197, I-419 P2X purinoceptor 3 Homo sapiens 32 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105909 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105909&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808535 174008220 ZINC96176770 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224178 COc1ccccc1C1C(C(=O)CC(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1cscn1 InChI=1S/C25H24N2O4S/c1-15(2)12-20(28)22-23(18-6-4-5-7-21(18)31-3)27(25(30)24(22)29)17-10-8-16(9-11-17)19-13-32-14-26-19/h4-11,13-15,22-23H,12H2,1-3H3 OFNMSFCYDODDPE-UHFFFAOYSA-N 105910 US8575197, I-420 P2X purinoceptor 3 Homo sapiens 257 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105910 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105910&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808536 174008221 ZINC96176771 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224179 COCCOc1ccccc1C1C(C(=O)CC(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1cscn1 InChI=1S/C27H28N2O5S/c1-17(2)14-22(30)24-25(20-6-4-5-7-23(20)34-13-12-33-3)29(27(32)26(24)31)19-10-8-18(9-11-19)21-15-35-16-28-21/h4-11,15-17,24-25H,12-14H2,1-3H3 ISUPSOOWBJINCB-UHFFFAOYSA-N 105911 US8575197, I-421 P2X purinoceptor 3 Homo sapiens 191 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105911 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105911&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808537 174008222 ZINC96176772 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224180 COCc1ccccc1C1C(C(=O)CC(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1cscn1 InChI=1S/C26H26N2O4S/c1-16(2)12-22(29)23-24(20-7-5-4-6-18(20)13-32-3)28(26(31)25(23)30)19-10-8-17(9-11-19)21-14-33-15-27-21/h4-11,14-16,23-24H,12-13H2,1-3H3 UBMKPAGMXVDTPO-UHFFFAOYSA-N 105912 US8575197, I-422 P2X purinoceptor 3 Homo sapiens 361 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105912 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105912&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808538 174008223 ZINC96176773 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224181 COCCOc1ccccc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1csc(C)n1 InChI=1S/C27H28N2O5S/c1-16(2)25(30)23-24(20-7-5-6-8-22(20)34-14-13-33-4)29(27(32)26(23)31)19-11-9-18(10-12-19)21-15-35-17(3)28-21/h5-12,15-16,23-24H,13-14H2,1-4H3 YVEFGWILWQLGAP-UHFFFAOYSA-N 105914 US8575197, I-424 P2X purinoceptor 3 Homo sapiens 519 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105914 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105914&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808539 174008225 ZINC96176775 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224182 COCc1ccccc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1csc(C)n1 InChI=1S/C26H26N2O4S/c1-15(2)24(29)22-23(20-8-6-5-7-18(20)13-32-4)28(26(31)25(22)30)19-11-9-17(10-12-19)21-14-33-16(3)27-21/h5-12,14-15,22-23H,13H2,1-4H3 OTFZAARQPOJRMX-UHFFFAOYSA-N 105915 US8575197, I-425 P2X purinoceptor 3 Homo sapiens 697 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105915 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105915&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808540 174008226 ZINC96176776 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224183 COCCOc1ccccc1C1C(C(=O)CC(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1csc(C)n1 InChI=1S/C28H30N2O5S/c1-17(2)15-23(31)25-26(21-7-5-6-8-24(21)35-14-13-34-4)30(28(33)27(25)32)20-11-9-19(10-12-20)22-16-36-18(3)29-22/h5-12,16-17,25-26H,13-15H2,1-4H3 SNBJCOWKKNKKJK-UHFFFAOYSA-N 105917 US8575197, I-427 P2X purinoceptor 3 Homo sapiens 331 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105917 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105917&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808541 174008228 ZINC96176778 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224184 COCc1ccccc1C1C(C(=O)CC(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1csc(C)n1 InChI=1S/C27H28N2O4S/c1-16(2)13-23(30)24-25(21-8-6-5-7-19(21)14-33-4)29(27(32)26(24)31)20-11-9-18(10-12-20)22-15-34-17(3)28-22/h5-12,15-16,24-25H,13-14H2,1-4H3 DJKGFDNQMSISGE-UHFFFAOYSA-N 105918 US8575197, I-428 P2X purinoceptor 3 Homo sapiens 399 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105918 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105918&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808542 174008229 ZINC96176779 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224185 CC(C)C(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1ccsc1)c1ccccc1OCCCO InChI=1S/C27H27NO5S/c1-17(2)25(30)23-24(21-6-3-4-7-22(21)33-14-5-13-29)28(27(32)26(23)31)20-10-8-18(9-11-20)19-12-15-34-16-19/h3-4,6-12,15-17,23-24,29H,5,13-14H2,1-2H3 JMQHHVMETYWQGS-UHFFFAOYSA-N 105919 US8575197, I-429 P2X purinoceptor 3 Homo sapiens 7 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105919 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105919&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808543 174008230 ZINC96176780 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224186 CC(C)CC(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1ccoc1)c1ccccc1C(=O)N(C)C InChI=1S/C28H28N2O5/c1-17(2)15-23(31)24-25(21-7-5-6-8-22(21)27(33)29(3)4)30(28(34)26(24)32)20-11-9-18(10-12-20)19-13-14-35-16-19/h5-14,16-17,24-25H,15H2,1-4H3 QCWGSHWSXHKGAR-UHFFFAOYSA-N 105920 US8575197, I-430 P2X purinoceptor 3 Homo sapiens 153 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105920 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105920&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808544 174008231 ZINC96176781 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224187 CC(C)Oc1ccccc1C1N(C(=O)C(=O)C1=C(C)C(C)C)c1ccc(cc1)-c1nc(C)no1 InChI=1S/C27H29N3O4/c1-15(2)17(5)23-24(21-9-7-8-10-22(21)33-16(3)4)30(27(32)25(23)31)20-13-11-19(12-14-20)26-28-18(6)29-34-26/h7-16,24H,1-6H3 VOMWEELCIKJQJK-UHFFFAOYSA-N 105921 US8575197, I-431 P2X purinoceptor 3 Homo sapiens 232 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105921 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105921&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808545 174008232 ZINC96176782 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224188 COCCOc1ncccc1[C@H]1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccsc1 InChI=1S/C26H26N2O5S/c1-16(2)23(29)21-22(20-5-4-11-27-25(20)33-13-12-32-3)28(26(31)24(21)30)19-8-6-17(7-9-19)18-10-14-34-15-18/h4-11,14-16,21-22H,12-13H2,1-3H3/t21?,22-/m0/s1 IWWLAXGNKQEFNJ-KEKNWZKVSA-N 105923 US8575197, I-433 P2X purinoceptor 3 Homo sapiens 425 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105923 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105923&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808546 174008234 ZINC96176784 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224189 COc1ccccc1C1C(C(=O)CC(C)C)C(=O)C(=O)N1c1ccc(SC)cc1 InChI=1S/C23H25NO4S/c1-14(2)13-18(25)20-21(17-7-5-6-8-19(17)28-3)24(23(27)22(20)26)15-9-11-16(29-4)12-10-15/h5-12,14,20-21H,13H2,1-4H3 KBXXEARFOZLUON-UHFFFAOYSA-N 105924 US8575197, I-434 P2X purinoceptor 3 Homo sapiens 125 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105924 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105924&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808547 174008235 ZINC96176785 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224190 COCCOc1ccccc1C1C(C(=O)CC(C)C)C(=O)C(=O)N1c1ccc(SC)cc1 InChI=1S/C25H29NO5S/c1-16(2)15-20(27)22-23(19-7-5-6-8-21(19)31-14-13-30-3)26(25(29)24(22)28)17-9-11-18(32-4)12-10-17/h5-12,16,22-23H,13-15H2,1-4H3 APBOMCDETILEPU-UHFFFAOYSA-N 105925 US8575197, I-435 P2X purinoceptor 3 Homo sapiens 82 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105925 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105925&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808548 174008236 ZINC96176786 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224191 CSc1ccc(cc1)N1C(C(C(=O)CC(C)C)C(=O)C1=O)c1ccccc1OC(C)C InChI=1S/C25H29NO4S/c1-15(2)14-20(27)22-23(19-8-6-7-9-21(19)30-16(3)4)26(25(29)24(22)28)17-10-12-18(31-5)13-11-17/h6-13,15-16,22-23H,14H2,1-5H3 GMKAXOPFVURWTM-UHFFFAOYSA-N 105926 US8575197, I-436 P2X purinoceptor 3 Homo sapiens 42 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105926 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105926&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808549 174008237 ZINC96176787 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224192 COCc1ccccc1C1C(C(=O)CC(C)C)C(=O)C(=O)N1c1ccc(SC)cc1 InChI=1S/C24H27NO4S/c1-15(2)13-20(26)21-22(19-8-6-5-7-16(19)14-29-3)25(24(28)23(21)27)17-9-11-18(30-4)12-10-17/h5-12,15,21-22H,13-14H2,1-4H3 YCIYEYVXMRFOCL-UHFFFAOYSA-N 105927 US8575197, I-437 P2X purinoceptor 3 Homo sapiens 111 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105927 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105927&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808550 174008238 ZINC96176788 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224193 Cc1nc(no1)-c1ccc(cc1)N1C(C(C(=O)CC2CCCC2)C(=O)C1=O)C1CCCCC1 InChI=1S/C26H31N3O4/c1-16-27-25(28-33-16)19-11-13-20(14-12-19)29-23(18-9-3-2-4-10-18)22(24(31)26(29)32)21(30)15-17-7-5-6-8-17/h11-14,17-18,22-23H,2-10,15H2,1H3 RPQZEADKFQYLGF-UHFFFAOYSA-N 105928 US8575197, I-438 P2X purinoceptor 3 Homo sapiens 490 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105928 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105928&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808551 174008239 ZINC96176789 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224194 COCc1ccccc1C1C(C(=O)CC2CCCC2)C(=O)C(=O)N1c1ccc(cc1)-c1ccsc1 InChI=1S/C29H29NO4S/c1-34-17-21-8-4-5-9-24(21)27-26(25(31)16-19-6-2-3-7-19)28(32)29(33)30(27)23-12-10-20(11-13-23)22-14-15-35-18-22/h4-5,8-15,18-19,26-27H,2-3,6-7,16-17H2,1H3 KFGRQEOIYVDVRS-UHFFFAOYSA-N 105929 US8575197, I-439 P2X purinoceptor 3 Homo sapiens 116 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105929 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105929&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808552 174008240 ZINC96176790 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224195 CCOc1ncccc1C1C(C(=O)CC(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccsc1 InChI=1S/C26H26N2O4S/c1-4-32-25-20(6-5-12-27-25)23-22(21(29)14-16(2)3)24(30)26(31)28(23)19-9-7-17(8-10-19)18-11-13-33-15-18/h5-13,15-16,22-23H,4,14H2,1-3H3 CJQDMJPMOCTECT-UHFFFAOYSA-N 105930 US8575197, I-440 P2X purinoceptor 3 Homo sapiens 35 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105930 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105930&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808553 174008241 ZINC96176791 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224196 CCOc1ncccc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccsc1 InChI=1S/C25H24N2O4S/c1-4-31-24-19(6-5-12-26-24)21-20(22(28)15(2)3)23(29)25(30)27(21)18-9-7-16(8-10-18)17-11-13-32-14-17/h5-15,20-21H,4H2,1-3H3 QDWXFWDYDWKIAZ-UHFFFAOYSA-N 105931 US8575197, I-441 P2X purinoceptor 3 Homo sapiens 13 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105931 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105931&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808554 174008242 ZINC96176792 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224197 CC(C)CC(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1ccsc1)c1ccccc1N1CCOCC1 InChI=1S/C29H30N2O4S/c1-19(2)17-25(32)26-27(23-5-3-4-6-24(23)30-12-14-35-15-13-30)31(29(34)28(26)33)22-9-7-20(8-10-22)21-11-16-36-18-21/h3-11,16,18-19,26-27H,12-15,17H2,1-2H3 IWRZFDVRNKFXFJ-UHFFFAOYSA-N 105932 US8575197, 655 P2X purinoceptor 3 Homo sapiens 5 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105932 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105932&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808555 174008243 ZINC96176793 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224198 CC(C)C(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1ccsc1)c1ccccc1N1CCOCC1 InChI=1S/C28H28N2O4S/c1-18(2)26(31)24-25(22-5-3-4-6-23(22)29-12-14-34-15-13-29)30(28(33)27(24)32)21-9-7-19(8-10-21)20-11-16-35-17-20/h3-11,16-18,24-25H,12-15H2,1-2H3 IYWNJXHUNVRFQZ-UHFFFAOYSA-N 105933 US8575197, I-443 P2X purinoceptor 3 Homo sapiens 6 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105933 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105933&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808556 174008244 ZINC96176794 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224199 CC(C)C(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1noc(C)n1)c1ccccc1OCCCO InChI=1S/C26H27N3O6/c1-15(2)23(31)21-22(19-7-4-5-8-20(19)34-14-6-13-30)29(26(33)24(21)32)18-11-9-17(10-12-18)25-27-16(3)35-28-25/h4-5,7-12,15,21-22,30H,6,13-14H2,1-3H3 NWMQIOZGEVKNNX-UHFFFAOYSA-N 105934 US8575197, I-444 P2X purinoceptor 3 Homo sapiens 172 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105934 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105934&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808557 174008245 ZINC96176795 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224200 CC(C)CC(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1noc(C)n1)c1ccccc1OCCCO InChI=1S/C27H29N3O6/c1-16(2)15-21(32)23-24(20-7-4-5-8-22(20)35-14-6-13-31)30(27(34)25(23)33)19-11-9-18(10-12-19)26-28-17(3)36-29-26/h4-5,7-12,16,23-24,31H,6,13-15H2,1-3H3 SXUHOKFZHAUVIZ-UHFFFAOYSA-N 105935 US8575197, I-445 P2X purinoceptor 3 Homo sapiens 152 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105935 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105935&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808558 174008246 ZINC96176796 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224201 COCCOc1ccccc1C1C(C(=O)CC(C)C)C(=O)C(=O)N1c1ccc(SC(F)(F)F)cc1 InChI=1S/C25H26F3NO5S/c1-15(2)14-19(30)21-22(18-6-4-5-7-20(18)34-13-12-33-3)29(24(32)23(21)31)16-8-10-17(11-9-16)35-25(26,27)28/h4-11,15,21-22H,12-14H2,1-3H3 HQLGEJDRWNHBBU-UHFFFAOYSA-N 105936 US8575197, I-446 P2X purinoceptor 3 Homo sapiens 338 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105936 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105936&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808559 174008247 ZINC96176797 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224202 CC(C)CC(=O)C1C(N(C(=O)C1=O)c1ccc(SC(F)(F)F)cc1)c1ccccc1OC(C)C InChI=1S/C25H26F3NO4S/c1-14(2)13-19(30)21-22(18-7-5-6-8-20(18)33-15(3)4)29(24(32)23(21)31)16-9-11-17(12-10-16)34-25(26,27)28/h5-12,14-15,21-22H,13H2,1-4H3 VEYOYGMFNRBSKR-UHFFFAOYSA-N 105937 US8575197, I-447 P2X purinoceptor 3 Homo sapiens 128 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105937 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105937&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808560 174008248 ZINC96176798 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224203 COCc1ccccc1C1C(C(=O)CC(C)C)C(=O)C(=O)N1c1ccc(SC(F)(F)F)cc1 InChI=1S/C24H24F3NO4S/c1-14(2)12-19(29)20-21(18-7-5-4-6-15(18)13-32-3)28(23(31)22(20)30)16-8-10-17(11-9-16)33-24(25,26)27/h4-11,14,20-21H,12-13H2,1-3H3 IXTIHLWQKCMIRZ-UHFFFAOYSA-N 105938 US8575197, I-448 P2X purinoceptor 3 Homo sapiens 246 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105938 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105938&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808561 174008249 ZINC96176799 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224204 CC(C)COc1ccccc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccsc1 InChI=1S/C28H29NO4S/c1-17(2)15-33-23-8-6-5-7-22(23)25-24(26(30)18(3)4)27(31)28(32)29(25)21-11-9-19(10-12-21)20-13-14-34-16-20/h5-14,16-18,24-25H,15H2,1-4H3 BPZPEKSNXWEDGV-UHFFFAOYSA-N 105939 US8575197, I-449 P2X purinoceptor 3 Homo sapiens 13 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105939 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105939&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808562 174008250 ZINC96176800 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224205 CC(C)COc1ccccc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccon1 InChI=1S/C27H28N2O5/c1-16(2)15-33-22-8-6-5-7-20(22)24-23(25(30)17(3)4)26(31)27(32)29(24)19-11-9-18(10-12-19)21-13-14-34-28-21/h5-14,16-17,23-24H,15H2,1-4H3 LFORNFBTRMDYJX-UHFFFAOYSA-N 105940 US8575197, I-450 P2X purinoceptor 3 Homo sapiens 36 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105940 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105940&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808563 174008251 ZINC96176801 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224206 CC(C)COc1ccccc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1noc(C)n1 InChI=1S/C27H29N3O5/c1-15(2)14-34-21-9-7-6-8-20(21)23-22(24(31)16(3)4)25(32)27(33)30(23)19-12-10-18(11-13-19)26-28-17(5)35-29-26/h6-13,15-16,22-23H,14H2,1-5H3 LDPUCBSBIPMURW-UHFFFAOYSA-N 105941 US8575197, I-451 P2X purinoceptor 3 Homo sapiens 19 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105941 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105941&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808564 174008252 ZINC96176802 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224207 COc1ccc(F)cc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccsc1 InChI=1S/C25H22FNO4S/c1-14(2)23(28)21-22(19-12-17(26)6-9-20(19)31-3)27(25(30)24(21)29)18-7-4-15(5-8-18)16-10-11-32-13-16/h4-14,21-22H,1-3H3 QKISPEOQHCDZQD-UHFFFAOYSA-N 105942 US8575197, I-452 P2X purinoceptor 3 Homo sapiens 26 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105942 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105942&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808565 174008253 ZINC96176803 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224208 COc1ccc(F)cc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1csc(C)c1 InChI=1S/C26H24FNO4S/c1-14(2)24(29)22-23(20-12-18(27)7-10-21(20)32-4)28(26(31)25(22)30)19-8-5-16(6-9-19)17-11-15(3)33-13-17/h5-14,22-23H,1-4H3 JEMFTPKGCWUJPB-UHFFFAOYSA-N 105943 US8575197, I-453 P2X purinoceptor 3 Homo sapiens 41 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105943 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105943&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808566 174008254 ZINC96176804 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224209 COc1ccc(F)cc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccc(C)o1 InChI=1S/C26H24FNO5/c1-14(2)24(29)22-23(19-13-17(27)8-12-21(19)32-4)28(26(31)25(22)30)18-9-6-16(7-10-18)20-11-5-15(3)33-20/h5-14,22-23H,1-4H3 IICAFSQOSKIMNC-UHFFFAOYSA-N 105944 US8575197, I-454 P2X purinoceptor 3 Homo sapiens 36 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105944 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105944&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808567 174008255 ZINC96176805 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224210 COCc1ccccc1[C@@H]1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1csc(C)c1 InChI=1S/C27H27NO4S/c1-16(2)25(29)23-24(22-8-6-5-7-19(22)14-32-4)28(27(31)26(23)30)21-11-9-18(10-12-21)20-13-17(3)33-15-20/h5-13,15-16,23-24H,14H2,1-4H3/t23?,24-/m1/s1 QCJAWEIJBAFKJA-XMMISQBUSA-N 105945 US8575197, I-455 P2X purinoceptor 3 Homo sapiens 14 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105945 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105945&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808568 174008256 ZINC96176806 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224211 CC(C)C(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1ccsc1)c1ccccc1OCC(CO)CO InChI=1S/C28H29NO6S/c1-17(2)26(32)24-25(22-5-3-4-6-23(22)35-15-18(13-30)14-31)29(28(34)27(24)33)21-9-7-19(8-10-21)20-11-12-36-16-20/h3-12,16-18,24-25,30-31H,13-15H2,1-2H3 HESLXJADZGNEMT-UHFFFAOYSA-N 105946 US8575197, I-456 P2X purinoceptor 3 Homo sapiens 6 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105946 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105946&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808569 174008257 ZINC96176807 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224212 COc1ccccc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1cc(C)on1 InChI=1S/C25H24N2O5/c1-14(2)23(28)21-22(18-7-5-6-8-20(18)31-4)27(25(30)24(21)29)17-11-9-16(10-12-17)19-13-15(3)32-26-19/h5-14,21-22H,1-4H3 OHDWAYWKEYWGBW-UHFFFAOYSA-N 105947 US8575197, I-457 P2X purinoceptor 3 Homo sapiens 488 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105947 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105947&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808570 174008258 ZINC96176808 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224213 COCc1ccccc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1cc(C)on1 InChI=1S/C26H26N2O5/c1-15(2)24(29)22-23(20-8-6-5-7-18(20)14-32-4)28(26(31)25(22)30)19-11-9-17(10-12-19)21-13-16(3)33-27-21/h5-13,15,22-23H,14H2,1-4H3 SOSVPCYKPHAMSP-UHFFFAOYSA-N 105948 US8575197, I-458 P2X purinoceptor 3 Homo sapiens 699 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105948 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105948&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808571 174008259 ZINC96176809 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224214 CC(C)Oc1ccccc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)N1CCCC1 InChI=1S/C27H32N2O4/c1-17(2)25(30)23-24(21-9-5-6-10-22(21)33-18(3)4)29(27(32)26(23)31)20-13-11-19(12-14-20)28-15-7-8-16-28/h5-6,9-14,17-18,23-24H,7-8,15-16H2,1-4H3 JZRKCVKMAIYJOI-UHFFFAOYSA-N 105949 US8575197, I-459 P2X purinoceptor 3 Homo sapiens 26 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105949 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105949&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808572 174008260 ZINC96176810 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224215 COc1ccccc1C1C(C(=O)c2cccnc2)C(=O)C(=O)N1c1ccc(cc1)-c1ccsc1 InChI=1S/C27H20N2O4S/c1-33-22-7-3-2-6-21(22)24-23(25(30)18-5-4-13-28-15-18)26(31)27(32)29(24)20-10-8-17(9-11-20)19-12-14-34-16-19/h2-16,23-24H,1H3 XPQHKSKFYZWFPG-UHFFFAOYSA-N 105950 US8575197, I-460 P2X purinoceptor 3 Homo sapiens 103 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105950 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105950&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808573 174008261 ZINC96176811 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224216 COCc1ccccc1C1C(C(=O)c2cccnc2)C(=O)C(=O)N1c1ccc(cc1)-c1ccsc1 InChI=1S/C28H22N2O4S/c1-34-16-20-5-2-3-7-23(20)25-24(26(31)19-6-4-13-29-15-19)27(32)28(33)30(25)22-10-8-18(9-11-22)21-12-14-35-17-21/h2-15,17,24-25H,16H2,1H3 RKOPZJSEYKISDN-UHFFFAOYSA-N 105951 US8575197, I-461 P2X purinoceptor 3 Homo sapiens 36 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105951 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105951&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808574 174008262 ZINC96176812 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224217 COc1ncccc1C1C(C(=O)CC(C)(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccsc1 InChI=1S/C26H26N2O4S/c1-26(2,3)14-20(29)21-22(19-6-5-12-27-24(19)32-4)28(25(31)23(21)30)18-9-7-16(8-10-18)17-11-13-33-15-17/h5-13,15,21-22H,14H2,1-4H3 HBQMRGINWSPKKL-UHFFFAOYSA-N 105952 US8575197, I-462 P2X purinoceptor 3 Homo sapiens 427 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105952 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105952&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808575 174008263 ZINC96176813 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224218 COCCOc1ncccc1C1C(C(=O)CC(C)(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccsc1 InChI=1S/C28H30N2O5S/c1-28(2,3)16-22(31)23-24(21-6-5-12-29-26(21)35-14-13-34-4)30(27(33)25(23)32)20-9-7-18(8-10-20)19-11-15-36-17-19/h5-12,15,17,23-24H,13-14,16H2,1-4H3 GGEJOOVCJBQBPQ-UHFFFAOYSA-N 105953 US8575197, I-463 P2X purinoceptor 3 Homo sapiens 127 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105953 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105953&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808576 174008264 ZINC96176814 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224219 CCc1nc2cc(ccc2o1)N1C(C(C(=O)C(C)C)C(=O)C1=O)c1ccccc1OC(C)C InChI=1S/C26H28N2O5/c1-6-21-27-18-13-16(11-12-20(18)33-21)28-23(17-9-7-8-10-19(17)32-15(4)5)22(24(29)14(2)3)25(30)26(28)31/h7-15,22-23H,6H2,1-5H3 CCNQHDIWJQDMEY-UHFFFAOYSA-N 105954 US8575197, I-464 P2X purinoceptor 3 Homo sapiens 453 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105954 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105954&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808577 174008265 ZINC96176815 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224220 COCCOc1ccccc1[C@@H]1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccc(C)s1 InChI=1S/C28H29NO5S/c1-17(2)26(30)24-25(21-7-5-6-8-22(21)34-16-15-33-4)29(28(32)27(24)31)20-12-10-19(11-13-20)23-14-9-18(3)35-23/h5-14,17,24-25H,15-16H2,1-4H3/t24?,25-/m1/s1 MJLQIYJLZJBNBG-WUBHUQEYSA-N 105955 US8575197, I-465 P2X purinoceptor 3 Homo sapiens 7 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105955 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105955&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808578 174008266 ZINC96176816 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224221 CN(C)C(=O)c1ccccc1C1C(C(=O)CC(C)(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccsc1 InChI=1S/C29H30N2O4S/c1-29(2,3)16-23(32)24-25(21-8-6-7-9-22(21)27(34)30(4)5)31(28(35)26(24)33)20-12-10-18(11-13-20)19-14-15-36-17-19/h6-15,17,24-25H,16H2,1-5H3 UDMBUOHYBXKLPN-UHFFFAOYSA-N 105956 US8575197, I-466 P2X purinoceptor 3 Homo sapiens 260 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105956 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105956&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808579 174008267 ZINC96176817 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224222 COc1ccccc1C1C(C(=O)C(=O)N1c1ccc(cc1)-c1ccc(C)o1)S(=O)(=O)C(C)C InChI=1S/C25H25NO6S/c1-15(2)33(29,30)24-22(19-7-5-6-8-21(19)31-4)26(25(28)23(24)27)18-12-10-17(11-13-18)20-14-9-16(3)32-20/h5-15,22,24H,1-4H3 UPDRUYSWNGGBSI-UHFFFAOYSA-N 105957 US8575197, I-467 P2X purinoceptor 3 Homo sapiens 286 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105957 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105957&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808580 174008268 ZINC96176818 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224223 COc1ccccc1C1C(C(=O)C(C)(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1cccs1 InChI=1S/C26H25NO4S/c1-26(2,3)24(29)21-22(18-8-5-6-9-19(18)31-4)27(25(30)23(21)28)17-13-11-16(12-14-17)20-10-7-15-32-20/h5-15,21-22H,1-4H3 QLQNSLWSLJGHJZ-UHFFFAOYSA-N 105569 US8575197, I-079 P2X purinoceptor 3 Homo sapiens 23 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105569 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105569&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808245 174007880 ZINC96176439 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224224 CC(C)(C)C(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1cccs1)c1ccccc1OCCO InChI=1S/C27H27NO5S/c1-27(2,3)25(31)22-23(19-7-4-5-8-20(19)33-15-14-29)28(26(32)24(22)30)18-12-10-17(11-13-18)21-9-6-16-34-21/h4-13,16,22-23,29H,14-15H2,1-3H3 DVRFHVSHZQINEG-UHFFFAOYSA-N 105570 US8575197, I-080 P2X purinoceptor 3 Homo sapiens 16 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105570 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105570&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808246 174007881 ZINC96176440 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224225 CSc1ccc(cc1)N1C(C(C(=O)C(C)(C)C)C(=O)C1=O)c1ccccc1OCCO InChI=1S/C24H27NO5S/c1-24(2,3)22(28)19-20(17-7-5-6-8-18(17)30-14-13-26)25(23(29)21(19)27)15-9-11-16(31-4)12-10-15/h5-12,19-20,26H,13-14H2,1-4H3 SUFJDWJGTMFJTQ-UHFFFAOYSA-N 105571 US8575197, I-081 P2X purinoceptor 3 Homo sapiens 151 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105571 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105571&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808247 174007882 ZINC96176441 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224226 CC(C)(C)C(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1nccs1)c1ccccc1OCCO InChI=1S/C26H26N2O5S/c1-26(2,3)23(31)20-21(18-6-4-5-7-19(18)33-14-13-29)28(25(32)22(20)30)17-10-8-16(9-11-17)24-27-12-15-34-24/h4-12,15,20-21,29H,13-14H2,1-3H3 MQRJXZJKZGQVCQ-UHFFFAOYSA-N 105572 US8575197, I-082 P2X purinoceptor 3 Homo sapiens 650 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105572 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105572&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808248 174007883 ZINC96176442 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224227 CC(C)(C)C(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1ccco1)c1ccccc1OCCO InChI=1S/C27H27NO6/c1-27(2,3)25(31)22-23(19-7-4-5-8-21(19)34-16-14-29)28(26(32)24(22)30)18-12-10-17(11-13-18)20-9-6-15-33-20/h4-13,15,22-23,29H,14,16H2,1-3H3 SKEXRBMITBEXBW-UHFFFAOYSA-N 105575 US8575197, I-085 P2X purinoceptor 3 Homo sapiens 48 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105575 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105575&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808249 174007886 ZINC96176445 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224228 Cc1nc(no1)-c1ccc(cc1)N1C(C(C(=O)C(C)(C)C)C(=O)C1=O)c1ccccc1OCCO InChI=1S/C26H27N3O6/c1-15-27-24(28-35-15)16-9-11-17(12-10-16)29-21(18-7-5-6-8-19(18)34-14-13-30)20(22(31)25(29)33)23(32)26(2,3)4/h5-12,20-21,30H,13-14H2,1-4H3 MGJSEZZFSOTNSR-UHFFFAOYSA-N 105579 US8575197, I-089 P2X purinoceptor 3 Homo sapiens 700 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105579 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105579&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808250 174007890 ZINC96176449 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224229 Cc1cc(on1)-c1ccc(cc1)N1C(C(C(=O)C(C)(C)C)C(=O)C1=O)c1ccccc1OCCO InChI=1S/C27H28N2O6/c1-16-15-21(35-28-16)17-9-11-18(12-10-17)29-23(19-7-5-6-8-20(19)34-14-13-30)22(24(31)26(29)33)25(32)27(2,3)4/h5-12,15,22-23,30H,13-14H2,1-4H3 ZIDAKXDCAWWKJK-UHFFFAOYSA-N 105580 US8575197, I-090 P2X purinoceptor 3 Homo sapiens 555 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105580 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105580&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808251 174007891 ZINC96176450 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224230 CCc1ccccc1C1C(C(=O)C(C)(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccon1 InChI=1S/C26H26N2O4/c1-5-16-8-6-7-9-19(16)22-21(24(30)26(2,3)4)23(29)25(31)28(22)18-12-10-17(11-13-18)20-14-15-32-27-20/h6-15,21-22H,5H2,1-4H3 MKHYPVJGCJKOBX-UHFFFAOYSA-N 105581 US8575197, I-091 P2X purinoceptor 3 Homo sapiens 341 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105581 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105581&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808252 174007892 ZINC96176451 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224231 COc1ccccc1C1C(C(=O)C(C)(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccco1 InChI=1S/C26H25NO5/c1-26(2,3)24(29)21-22(18-8-5-6-9-20(18)31-4)27(25(30)23(21)28)17-13-11-16(12-14-17)19-10-7-15-32-19/h5-15,21-22H,1-4H3 VHEMYVJLGFHTCK-UHFFFAOYSA-N 105582 US8575197, I-092 P2X purinoceptor 3 Homo sapiens 92 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105582 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105582&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808253 174007893 ZINC96176452 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224232 COc1ccccc1C1C(C(=O)C(C)(C)C)C(=O)C(=O)N1c1ccc(nc1)-c1ccoc1 InChI=1S/C25H24N2O5/c1-25(2,3)23(29)20-21(17-7-5-6-8-19(17)31-4)27(24(30)22(20)28)16-9-10-18(26-13-16)15-11-12-32-14-15/h5-14,20-21H,1-4H3 FDHAYSXROXWARS-UHFFFAOYSA-N 105583 US8575197, I-093 P2X purinoceptor 3 Homo sapiens 756 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105583 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105583&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808254 174007894 ZINC96176453 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224233 COc1ccccc1C1C(C(=O)C(C)(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1cc[nH]c1 InChI=1S/C26H26N2O4/c1-26(2,3)24(30)21-22(19-7-5-6-8-20(19)32-4)28(25(31)23(21)29)18-11-9-16(10-12-18)17-13-14-27-15-17/h5-15,21-22,27H,1-4H3 LLSQMHHWFSTKIE-UHFFFAOYSA-N 105584 US8575197, I-094 P2X purinoceptor 3 Homo sapiens 301 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105584 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105584&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808255 174007895 ZINC96176454 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224234 COc1ccccc1C1C2C(=O)C(C)(C)COC2(O)C(=O)N1c1ccc(cn1)-c1ccsc1 InChI=1S/C25H24N2O5S/c1-24(2)14-32-25(30)20(22(24)28)21(17-6-4-5-7-18(17)31-3)27(23(25)29)19-9-8-15(12-26-19)16-10-11-33-13-16/h4-13,20-21,30H,14H2,1-3H3 LHTPNMKBQSMAPX-UHFFFAOYSA-N 105585 US8575197, I-095 P2X purinoceptor 3 Homo sapiens 195 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105585 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105585&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58366101 174007896 ZINC96176455 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224235 COCCOc1ccccc1C1C(C(=O)C(C)(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccon1 InChI=1S/C27H28N2O6/c1-27(2,3)25(31)22-23(19-7-5-6-8-21(19)34-16-15-33-4)29(26(32)24(22)30)18-11-9-17(10-12-18)20-13-14-35-28-20/h5-14,22-23H,15-16H2,1-4H3 BSMAFXDAUPICOA-UHFFFAOYSA-N 105588 US8575197, I-098 P2X purinoceptor 3 Homo sapiens 370 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105588 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105588&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808256 174007899 ZINC96176458 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224236 COc1ccccc1C1N(C(=O)C(N)=C1C(=O)C(C)(C)C)c1ccc(cc1)-c1ccon1 InChI=1S/C25H25N3O4/c1-25(2,3)23(29)20-21(26)24(30)28(22(20)17-7-5-6-8-19(17)31-4)16-11-9-15(10-12-16)18-13-14-32-27-18/h5-14,22H,26H2,1-4H3 OEAWDJCECNRYGY-UHFFFAOYSA-N 105592 US8575197, I-102 P2X purinoceptor 3 Homo sapiens 134 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105592 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105592&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 73265430 174007903 ZINC96176461 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224237 CC(C)(C)C(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1ccon1)c1ccccc1OCC#N InChI=1S/C26H23N3O5/c1-26(2,3)24(31)21-22(18-6-4-5-7-20(18)33-15-13-27)29(25(32)23(21)30)17-10-8-16(9-11-17)19-12-14-34-28-19/h4-12,14,21-22H,15H2,1-3H3 RJDSCJGURDCQFI-UHFFFAOYSA-N 105593 US8575197, I-103 P2X purinoceptor 3 Homo sapiens 355 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105593 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105593&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808257 174007904 ZINC96176462 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224238 CC(C)(C)C(=O)C1=C(O)C(=O)N(C1c1cccc[n+]1[O-])c1ccc(cc1)-c1ccsc1 InChI=1S/C24H22N2O4S/c1-24(2,3)22(28)19-20(18-6-4-5-12-25(18)30)26(23(29)21(19)27)17-9-7-15(8-10-17)16-11-13-31-14-16/h4-14,20,27H,1-3H3 MISGVPYITHFBLI-UHFFFAOYSA-N 105594 US8575197, I-104 P2X purinoceptor 3 Homo sapiens 424 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105594 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105594&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365687 174007905 ZINC96176463 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224239 CC(C)Oc1ccccc1C1C(C(=O)C(C)(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccon1 InChI=1S/C27H28N2O5/c1-16(2)34-21-9-7-6-8-19(21)23-22(25(31)27(3,4)5)24(30)26(32)29(23)18-12-10-17(11-13-18)20-14-15-33-28-20/h6-16,22-23H,1-5H3 AIJHJHDJVOVJQG-UHFFFAOYSA-N 105595 US8575197, I-105 P2X purinoceptor 3 Homo sapiens 97 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105595 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105595&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808258 174007906 ZINC96176464 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224240 COc1ncccc1C1C(C(=O)C(C)(C)C)C(=O)C(=O)N1c1ccc(nc1)-c1ccsc1 InChI=1S/C24H23N3O4S/c1-24(2,3)21(29)18-19(16-6-5-10-25-22(16)31-4)27(23(30)20(18)28)15-7-8-17(26-12-15)14-9-11-32-13-14/h5-13,18-19H,1-4H3 KUEHHYWBXIVVJF-UHFFFAOYSA-N 105598 US8575197, I-108 P2X purinoceptor 3 Homo sapiens 192 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105598 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105598&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808259 174007909 ZINC96176467 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224241 CC(C)(C)C(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1ccon1)c1ccccc1S(C)(=O)=O InChI=1S/C25H24N2O6S/c1-25(2,3)23(29)20-21(17-7-5-6-8-19(17)34(4,31)32)27(24(30)22(20)28)16-11-9-15(10-12-16)18-13-14-33-26-18/h5-14,20-21H,1-4H3 UDCXPUZLQMFRFI-UHFFFAOYSA-N 105601 US8575197, I-111 P2X purinoceptor 3 Homo sapiens 624 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105601 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105601&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808260 174007912 ZINC96176470 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224242 CC(C)(C)C(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1cccs1)c1cccc[n+]1[O-] InChI=1S/C24H22N2O4S/c1-24(2,3)22(28)19-20(17-7-4-5-13-25(17)30)26(23(29)21(19)27)16-11-9-15(10-12-16)18-8-6-14-31-18/h4-14,19-20H,1-3H3 USYMWIOXJSMHKD-UHFFFAOYSA-N 105602 US8575197, I-112 P2X purinoceptor 3 Homo sapiens 388 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105602 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105602&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808261 174007913 ZINC96176471 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224243 COC(=O)COc1ccccc1C1C(C(=O)C(C)(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1cccs1 InChI=1S/C28H27NO6S/c1-28(2,3)26(32)23-24(19-8-5-6-9-20(19)35-16-22(30)34-4)29(27(33)25(23)31)18-13-11-17(12-14-18)21-10-7-15-36-21/h5-15,23-24H,16H2,1-4H3 ZFRZTMGSTVTHGF-UHFFFAOYSA-N 105603 US8575197, I-113 P2X purinoceptor 3 Homo sapiens 12 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105603 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105603&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808262 174007914 ZINC96176472 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224244 COC(=O)COc1ccccc1C1C(C(=O)C(C)(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccsc1 InChI=1S/C28H27NO6S/c1-28(2,3)26(32)23-24(20-7-5-6-8-21(20)35-15-22(30)34-4)29(27(33)25(23)31)19-11-9-17(10-12-19)18-13-14-36-16-18/h5-14,16,23-24H,15H2,1-4H3 JNOPUACFKNUWKK-UHFFFAOYSA-N 105604 US8575197, I-114 P2X purinoceptor 3 Homo sapiens 12 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105604 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105604&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808263 174007915 ZINC96176473 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224245 COc1ncccc1C1C(C(=O)C(C)(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1cccs1 InChI=1S/C25H24N2O4S/c1-25(2,3)22(29)19-20(17-7-5-13-26-23(17)31-4)27(24(30)21(19)28)16-11-9-15(10-12-16)18-8-6-14-32-18/h5-14,19-20H,1-4H3 PBLWBFXYPFTGGY-UHFFFAOYSA-N 105605 US8575197, I-115 P2X purinoceptor 3 Homo sapiens 108 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105605 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105605&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808264 174007916 ZINC96176474 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224246 COc1ncccc1C1C(C(=O)C(C)(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccsc1 InChI=1S/C25H24N2O4S/c1-25(2,3)22(29)19-20(18-6-5-12-26-23(18)31-4)27(24(30)21(19)28)17-9-7-15(8-10-17)16-11-13-32-14-16/h5-14,19-20H,1-4H3 XYQUSFSJSKTUIS-UHFFFAOYSA-N 105606 US8575197, I-116 P2X purinoceptor 3 Homo sapiens 77 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105606 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105606&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808265 174007917 ZINC96176475 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224247 COc1ncccc1C1C(C(=O)C(C)(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccco1 InChI=1S/C25H24N2O5/c1-25(2,3)22(29)19-20(17-7-5-13-26-23(17)31-4)27(24(30)21(19)28)16-11-9-15(10-12-16)18-8-6-14-32-18/h5-14,19-20H,1-4H3 NHUFTWRRJSHXFE-UHFFFAOYSA-N 105607 US8575197, I-117 P2X purinoceptor 3 Homo sapiens 383 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105607 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105607&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808266 174007918 ZINC96176476 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224248 COc1ncccc1C1C(C(=O)C(C)(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccoc1 InChI=1S/C25H24N2O5/c1-25(2,3)22(29)19-20(18-6-5-12-26-23(18)31-4)27(24(30)21(19)28)17-9-7-15(8-10-17)16-11-13-32-14-16/h5-14,19-20H,1-4H3 LUDKIARNWOLDIR-UHFFFAOYSA-N 105608 US8575197, I-118 P2X purinoceptor 3 Homo sapiens 282 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105608 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105608&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808267 174007919 ZINC96176477 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224249 CC(C)(C)C(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1cccs1)c1ccccc1OCC(O)=O InChI=1S/C27H25NO6S/c1-27(2,3)25(32)22-23(18-7-4-5-8-19(18)34-15-21(29)30)28(26(33)24(22)31)17-12-10-16(11-13-17)20-9-6-14-35-20/h4-14,22-23H,15H2,1-3H3,(H,29,30) ZQVMLJYLJAUYHT-UHFFFAOYSA-N 105609 US8575197, I-119 P2X purinoceptor 3 Homo sapiens 98 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105609 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105609&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808268 174007920 ZINC96176478 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224250 CC(C)(C)C(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1ccsc1)c1ccccc1OCC(O)=O InChI=1S/C27H25NO6S/c1-27(2,3)25(32)22-23(19-6-4-5-7-20(19)34-14-21(29)30)28(26(33)24(22)31)18-10-8-16(9-11-18)17-12-13-35-15-17/h4-13,15,22-23H,14H2,1-3H3,(H,29,30) CPKFYCNPRLIMOP-UHFFFAOYSA-N 105610 US8575197, I-120 P2X purinoceptor 3 Homo sapiens 74 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105610 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105610&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808269 174007921 ZINC96176479 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224251 COc1ncccc1C1C(C(=O)C(C)(C)C)C(=O)C(=O)N1c1ccc(nc1)-c1cccs1 InChI=1S/C24H23N3O4S/c1-24(2,3)21(29)18-19(15-7-5-11-25-22(15)31-4)27(23(30)20(18)28)14-9-10-16(26-13-14)17-8-6-12-32-17/h5-13,18-19H,1-4H3 SLFAUUBWUXTUJK-UHFFFAOYSA-N 105612 US8575197, I-122 P2X purinoceptor 3 Homo sapiens 342 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105612 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105612&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808270 174007923 ZINC96176481 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224252 COCCOc1ccccc1C1C(C(=O)C(C)(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1cccs1 InChI=1S/C28H29NO5S/c1-28(2,3)26(31)23-24(20-8-5-6-9-21(20)34-16-15-33-4)29(27(32)25(23)30)19-13-11-18(12-14-19)22-10-7-17-35-22/h5-14,17,23-24H,15-16H2,1-4H3 XRLZWVMZVVNSFO-UHFFFAOYSA-N 105613 US8575197, I-123 P2X purinoceptor 3 Homo sapiens 13 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105613 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105613&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808271 174007924 ZINC96176482 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224253 COCCOc1ccccc1C1C(C(=O)C(C)(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccsc1 InChI=1S/C28H29NO5S/c1-28(2,3)26(31)23-24(21-7-5-6-8-22(21)34-15-14-33-4)29(27(32)25(23)30)20-11-9-18(10-12-20)19-13-16-35-17-19/h5-13,16-17,23-24H,14-15H2,1-4H3 CLVOUMBEQSSRFP-UHFFFAOYSA-N 105614 US8575197, I-124 P2X purinoceptor 3 Homo sapiens 11 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105614 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105614&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808272 174007925 ZINC96176483 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224254 COc1ccc(cc1)C(=O)C1C(N(C(=O)C1=O)c1nc2cc(OC)ccc2s1)c1ccccc1OCCO InChI=1S/C28H24N2O7S/c1-35-17-9-7-16(8-10-17)25(32)23-24(19-5-3-4-6-21(19)37-14-13-31)30(27(34)26(23)33)28-29-20-15-18(36-2)11-12-22(20)38-28/h3-12,15,23-24,31H,13-14H2,1-2H3 BNFWNIHEMYQOBE-UHFFFAOYSA-N 105615 US8575197, I-125 P2X purinoceptor 3 Homo sapiens 110 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105615 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105615&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808273 174007926 ZINC96176484 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224255 COc1ccc(cc1)C(=O)C1C(N(C(=O)C1=O)c1nc2ccc(OC)cc2s1)c1ccccc1OCCO InChI=1S/C28H24N2O7S/c1-35-17-9-7-16(8-10-17)25(32)23-24(19-5-3-4-6-21(19)37-14-13-31)30(27(34)26(23)33)28-29-20-12-11-18(36-2)15-22(20)38-28/h3-12,15,23-24,31H,13-14H2,1-2H3 MILBEHPYZMEKGY-UHFFFAOYSA-N 105616 US8575197, I-126 P2X purinoceptor 3 Homo sapiens 15 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105616 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105616&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808274 174007927 ZINC96176485 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224256 COc1ccc(cc1)C(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1ccon1)c1ccccc1OCCO InChI=1S/C29H24N2O7/c1-36-21-12-8-19(9-13-21)27(33)25-26(22-4-2-3-5-24(22)37-17-15-32)31(29(35)28(25)34)20-10-6-18(7-11-20)23-14-16-38-30-23/h2-14,16,25-26,32H,15,17H2,1H3 QPHUBOVRINGSEE-UHFFFAOYSA-N 105617 US8575197, I-127 P2X purinoceptor 3 Homo sapiens 49 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105617 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105617&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808275 174007928 ZINC96176486 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224257 COCCOc1ccccc1C1C(C(=O)C(C)(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1nc(C)no1 InChI=1S/C27H29N3O6/c1-16-28-25(36-29-16)17-10-12-18(13-11-17)30-22(19-8-6-7-9-20(19)35-15-14-34-5)21(23(31)26(30)33)24(32)27(2,3)4/h6-13,21-22H,14-15H2,1-5H3 KDKSEGYNWVZVOQ-UHFFFAOYSA-N 105618 US8575197, I-128 P2X purinoceptor 3 Homo sapiens 155 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105618 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105618&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808276 174007929 ZINC96176487 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224258 COCCOc1ccccc1C1C(C(=O)C(C)(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1noc(C)n1 InChI=1S/C27H29N3O6/c1-16-28-25(29-36-16)17-10-12-18(13-11-17)30-22(19-8-6-7-9-20(19)35-15-14-34-5)21(23(31)26(30)33)24(32)27(2,3)4/h6-13,21-22H,14-15H2,1-5H3 NHLAJDIFGLMNSC-UHFFFAOYSA-N 105619 US8575197, I-129 P2X purinoceptor 3 Homo sapiens 91 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105619 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105619&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808277 174007930 ZINC96176488 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224259 COCCOc1ccccc1C1C(C(=O)C(C)(C)C)C(=O)C(=O)N1c1ccc(SC)cc1 InChI=1S/C25H29NO5S/c1-25(2,3)23(28)20-21(18-8-6-7-9-19(18)31-15-14-30-4)26(24(29)22(20)27)16-10-12-17(32-5)13-11-16/h6-13,20-21H,14-15H2,1-5H3 VZBSVCKVBQOUML-UHFFFAOYSA-N 105620 US8575197, I-130 P2X purinoceptor 3 Homo sapiens 476 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105620 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105620&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808278 174007931 ZINC96176489 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224260 COc1ccc(cc1)C(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1ccon1)c1ccc(Br)cc1OC InChI=1S/C28H21BrN2O6/c1-35-20-10-5-17(6-11-20)26(32)24-25(21-12-7-18(29)15-23(21)36-2)31(28(34)27(24)33)19-8-3-16(4-9-19)22-13-14-37-30-22/h3-15,24-25H,1-2H3 VCQDQFUCJBXYPR-UHFFFAOYSA-N 105621 US8575197, I-131 P2X purinoceptor 3 Homo sapiens 251 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105621 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105621&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808279 174007932 ZINC96176490 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224261 COCCOc1ccccc1C1C(C(=O)C(C)(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccco1 InChI=1S/C28H29NO6/c1-28(2,3)26(31)23-24(20-8-5-6-9-22(20)35-17-16-33-4)29(27(32)25(23)30)19-13-11-18(12-14-19)21-10-7-15-34-21/h5-15,23-24H,16-17H2,1-4H3 OXFMKOXMQHVKPB-UHFFFAOYSA-N 105622 US8575197, I-132 P2X purinoceptor 3 Homo sapiens 43 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105622 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105622&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808280 174007933 ZINC96176491 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224262 COC(=O)COc1ccccc1C1C(C(=O)C(C)(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccon1 InChI=1S/C27H26N2O7/c1-27(2,3)25(32)22-23(18-7-5-6-8-20(18)35-15-21(30)34-4)29(26(33)24(22)31)17-11-9-16(10-12-17)19-13-14-36-28-19/h5-14,22-23H,15H2,1-4H3 GASQONKTEMWBOQ-UHFFFAOYSA-N 105623 US8575197, I-133 P2X purinoceptor 3 Homo sapiens 367 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105623 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105623&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808281 174007934 ZINC96176492 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224263 CC(C)(C)C(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1ccon1)c1ccccc1OCC(O)=O InChI=1S/C26H24N2O7/c1-26(2,3)24(32)21-22(17-6-4-5-7-19(17)34-14-20(29)30)28(25(33)23(21)31)16-10-8-15(9-11-16)18-12-13-35-27-18/h4-13,21-22H,14H2,1-3H3,(H,29,30) CVKQUDSUCQHYBN-UHFFFAOYSA-N 105624 US8575197, I-134 P2X purinoceptor 3 Homo sapiens 776 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105624 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105624&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808282 174007935 ZINC96176493 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224264 CN(C)CCOc1ccccc1C1C(C(=O)C(C)(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccsc1 InChI=1S/C29H32N2O4S/c1-29(2,3)27(33)24-25(22-8-6-7-9-23(22)35-16-15-30(4)5)31(28(34)26(24)32)21-12-10-19(11-13-21)20-14-17-36-18-20/h6-14,17-18,24-25H,15-16H2,1-5H3 GHSAQFBEVBKLAC-UHFFFAOYSA-N 105625 US8575197, 239::US8575197, 240 P2X purinoceptor 3 Homo sapiens 15 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105625 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105625&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808283 174007936 ZINC96176494 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224265 CN(C)CCOc1ccccc1C1C(C(=O)C(C)(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccsc1 InChI=1S/C29H32N2O4S/c1-29(2,3)27(33)24-25(22-8-6-7-9-23(22)35-16-15-30(4)5)31(28(34)26(24)32)21-12-10-19(11-13-21)20-14-17-36-18-20/h6-14,17-18,24-25H,15-16H2,1-5H3 GHSAQFBEVBKLAC-UHFFFAOYSA-N 105625 US8575197, 239::US8575197, 240 P2X purinoceptor 3 Homo sapiens 15 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105625 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105625&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808283 174007936 ZINC96176494 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224266 CN(C)CCOc1ccccc1C1C(C(=O)C(C)(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccon1 InChI=1S/C28H31N3O5/c1-28(2,3)26(33)23-24(20-8-6-7-9-22(20)35-17-15-30(4)5)31(27(34)25(23)32)19-12-10-18(11-13-19)21-14-16-36-29-21/h6-14,16,23-24H,15,17H2,1-5H3 MUHDEJKPFFJEOY-UHFFFAOYSA-N 105627 US8575197, I-137 P2X purinoceptor 3 Homo sapiens 615 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105627 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105627&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808284 174007938 ZINC96176495 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224267 COCCOc1ncccc1C1C(C(=O)C(C)(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccsc1 InChI=1S/C27H28N2O5S/c1-27(2,3)24(31)21-22(20-6-5-12-28-25(20)34-14-13-33-4)29(26(32)23(21)30)19-9-7-17(8-10-19)18-11-15-35-16-18/h5-12,15-16,21-22H,13-14H2,1-4H3 DWHHZCDTLINJPJ-UHFFFAOYSA-N 105628 US8575197, I-138 P2X purinoceptor 3 Homo sapiens 16 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105628 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105628&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808285 174007939 ZINC96176496 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224268 COCCOc1ncccc1C1C(C(=O)C(C)(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccon1 InChI=1S/C26H27N3O6/c1-26(2,3)23(31)20-21(18-6-5-12-27-24(18)34-15-14-33-4)29(25(32)22(20)30)17-9-7-16(8-10-17)19-11-13-35-28-19/h5-13,20-21H,14-15H2,1-4H3 HKAJDVBSGPKCBX-UHFFFAOYSA-N 105629 US8575197, I-139 P2X purinoceptor 3 Homo sapiens 930 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105629 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105629&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808286 174007940 ZINC96176497 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224269 Cc1ncccc1C1C(C(=O)C(C)(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1cccs1 InChI=1S/C25H24N2O3S/c1-15-18(7-5-13-26-15)21-20(23(29)25(2,3)4)22(28)24(30)27(21)17-11-9-16(10-12-17)19-8-6-14-31-19/h5-14,20-21H,1-4H3 JJEPLHGQQJKUTF-UHFFFAOYSA-N 105631 US8575197, I-141 P2X purinoceptor 3 Homo sapiens 346 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105631 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105631&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808287 174007942 ZINC96176499 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224270 Cc1ncccc1C1C(C(=O)C(C)(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccco1 InChI=1S/C25H24N2O4/c1-15-18(7-5-13-26-15)21-20(23(29)25(2,3)4)22(28)24(30)27(21)17-11-9-16(10-12-17)19-8-6-14-31-19/h5-14,20-21H,1-4H3 JVXCSRKIMVNCIE-UHFFFAOYSA-N 105632 US8575197, I-142 P2X purinoceptor 3 Homo sapiens 315 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105632 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105632&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808288 174007943 ZINC96176500 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224271 Cc1ncccc1C1C(C(=O)C(C)(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccsc1 InChI=1S/C25H24N2O3S/c1-15-19(6-5-12-26-15)21-20(23(29)25(2,3)4)22(28)24(30)27(21)18-9-7-16(8-10-18)17-11-13-31-14-17/h5-14,20-21H,1-4H3 FALNGXSBXNZBAC-UHFFFAOYSA-N 105633 US8575197, I-143 P2X purinoceptor 3 Homo sapiens 331 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105633 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105633&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808289 174007944 ZINC96176501 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224272 COc1ccccc1[C@H]1C(C(=O)CC(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccsc1 InChI=1S/C26H25NO4S/c1-16(2)14-21(28)23-24(20-6-4-5-7-22(20)31-3)27(26(30)25(23)29)19-10-8-17(9-11-19)18-12-13-32-15-18/h4-13,15-16,23-24H,14H2,1-3H3/t23?,24-/m0/s1 QYDKUBONZZJGAP-CGAIIQECSA-N 105770 US8575197, I-280 P2X purinoceptor 3 Homo sapiens 477 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105770 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105770&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808411 174008081 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224273 COCc1ccccc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(I)cc1 InChI=1S/C22H22INO4/c1-13(2)20(25)18-19(17-7-5-4-6-14(17)12-28-3)24(22(27)21(18)26)16-10-8-15(23)9-11-16/h4-11,13,18-19H,12H2,1-3H3 VFQDZWVJUSDRCA-UHFFFAOYSA-N 105771 US8575197, I-281 P2X purinoceptor 3 Homo sapiens 637 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105771 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105771&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808412 174008082 ZINC96176633 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224274 COCc1ccccc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccccc1 InChI=1S/C28H27NO4/c1-18(2)26(30)24-25(23-12-8-7-11-21(23)17-33-3)29(28(32)27(24)31)22-15-13-20(14-16-22)19-9-5-4-6-10-19/h4-16,18,24-25H,17H2,1-3H3 DADQYROIESRPBD-UHFFFAOYSA-N 105772 US8575197, I-282 P2X purinoceptor 3 Homo sapiens 472 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105772 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105772&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808413 174008083 ZINC96176634 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224275 COCc1ccccc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(s1)-c1ccccc1 InChI=1S/C26H25NO4S/c1-16(2)24(28)22-23(19-12-8-7-11-18(19)15-31-3)27(26(30)25(22)29)21-14-13-20(32-21)17-9-5-4-6-10-17/h4-14,16,22-23H,15H2,1-3H3 RSXZUNOQHINBDN-UHFFFAOYSA-N 105773 US8575197, I-283 P2X purinoceptor 3 Homo sapiens 144 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105773 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105773&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808414 174008084 ZINC96176635 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224276 COc1cccc(c1)C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccsc1 InChI=1S/C25H23NO4S/c1-15(2)23(27)21-22(17-5-4-6-20(13-17)30-3)26(25(29)24(21)28)19-9-7-16(8-10-19)18-11-12-31-14-18/h4-15,21-22H,1-3H3 QLEPVKCHWYTPJD-UHFFFAOYSA-N 105774 US8575197, I-284 P2X purinoceptor 3 Homo sapiens 300 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105774 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105774&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808415 174008085 ZINC96176636 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224277 COc1ccc(cc1)C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccsc1 InChI=1S/C25H23NO4S/c1-15(2)23(27)21-22(17-6-10-20(30-3)11-7-17)26(25(29)24(21)28)19-8-4-16(5-9-19)18-12-13-31-14-18/h4-15,21-22H,1-3H3 BGWBZUWZCXUUHA-UHFFFAOYSA-N 105775 US8575197, I-285 P2X purinoceptor 3 Homo sapiens 648 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105775 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105775&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808416 174008086 ZINC96176637 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224278 COCCOc1cccc(c1)C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccsc1 InChI=1S/C27H27NO5S/c1-17(2)25(29)23-24(19-5-4-6-22(15-19)33-13-12-32-3)28(27(31)26(23)30)21-9-7-18(8-10-21)20-11-14-34-16-20/h4-11,14-17,23-24H,12-13H2,1-3H3 ULNZWHVBUKPXHJ-UHFFFAOYSA-N 105776 US8575197, I-286 P2X purinoceptor 3 Homo sapiens 669 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105776 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105776&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808417 174008087 ZINC96176638 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224279 COc1ccc(cn1)C(=O)C1C(C2COC(C)(C)OC2)N(C(=O)C1=O)c1ccc(cc1)-c1ccsc1 InChI=1S/C27H26N2O6S/c1-27(2)34-13-19(14-35-27)23-22(24(30)17-6-9-21(33-3)28-12-17)25(31)26(32)29(23)20-7-4-16(5-8-20)18-10-11-36-15-18/h4-12,15,19,22-23H,13-14H2,1-3H3 FCBODLDICMEZSC-UHFFFAOYSA-N 105778 US8575197, I-288 P2X purinoceptor 3 Homo sapiens 36 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105778 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105778&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808418 174008089 ZINC96176640 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224280 CC(C)CC(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1ccsc1)c1ccccc1OC(F)F InChI=1S/C26H23F2NO4S/c1-15(2)13-20(30)22-23(19-5-3-4-6-21(19)33-26(27)28)29(25(32)24(22)31)18-9-7-16(8-10-18)17-11-12-34-14-17/h3-12,14-15,22-23,26H,13H2,1-2H3 ILEFDXPWDVJTRY-UHFFFAOYSA-N 105780 US8575197, I-290 P2X purinoceptor 3 Homo sapiens 51 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105780 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105780&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808419 174008091 ZINC96176642 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224281 COc1ncccc1C1C(C(=O)CC(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccsc1 InChI=1S/C25H24N2O4S/c1-15(2)13-20(28)21-22(19-5-4-11-26-24(19)31-3)27(25(30)23(21)29)18-8-6-16(7-9-18)17-10-12-32-14-17/h4-12,14-15,21-22H,13H2,1-3H3 ZITZWZONMAWZEL-UHFFFAOYSA-N 105781 US8575197, I-291 P2X purinoceptor 3 Homo sapiens 130 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105781 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105781&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808420 174008092 ZINC96176643 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224282 CC(C)CC(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1ccsc1)c1ccccc1C(F)(F)F InChI=1S/C26H22F3NO3S/c1-15(2)13-21(31)22-23(19-5-3-4-6-20(19)26(27,28)29)30(25(33)24(22)32)18-9-7-16(8-10-18)17-11-12-34-14-17/h3-12,14-15,22-23H,13H2,1-2H3 AFXQVJKNVUXVFH-UHFFFAOYSA-N 105782 US8575197, I-292 P2X purinoceptor 3 Homo sapiens 127 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105782 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105782&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808421 174008093 ZINC96176644 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224283 CC(C)CC(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1ccsc1)c1ccccc1OC(C)C InChI=1S/C28H29NO4S/c1-17(2)15-23(30)25-26(22-7-5-6-8-24(22)33-18(3)4)29(28(32)27(25)31)21-11-9-19(10-12-21)20-13-14-34-16-20/h5-14,16-18,25-26H,15H2,1-4H3 UPSNYTPRJDPUSK-UHFFFAOYSA-N 105783 US8575197, I-293 P2X purinoceptor 3 Homo sapiens 12 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105783 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105783&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808422 174008094 ZINC96176645 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224284 CC(C)Oc1ccccc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccon1 InChI=1S/C26H26N2O5/c1-15(2)24(29)22-23(19-7-5-6-8-21(19)33-16(3)4)28(26(31)25(22)30)18-11-9-17(10-12-18)20-13-14-32-27-20/h5-16,22-23H,1-4H3 PVPQMQZFOAZKLA-UHFFFAOYSA-N 105785 US8575197, I-295 P2X purinoceptor 3 Homo sapiens 54 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105785 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105785&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808423 174008096 ZINC96176647 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224285 CC(C)C(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1ccon1)c1ccccc1OC(F)F InChI=1S/C24H20F2N2O5/c1-13(2)21(29)19-20(16-5-3-4-6-18(16)33-24(25)26)28(23(31)22(19)30)15-9-7-14(8-10-15)17-11-12-32-27-17/h3-13,19-20,24H,1-2H3 RVXCJHVXGTUSRS-UHFFFAOYSA-N 105786 US8575197, I-296 P2X purinoceptor 3 Homo sapiens 244 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105786 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105786&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808424 174008097 ZINC96176648 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224286 CC(C)C(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1ccon1)c1ccccc1OC(F)(F)F InChI=1S/C24H19F3N2O5/c1-13(2)21(30)19-20(16-5-3-4-6-18(16)34-24(25,26)27)29(23(32)22(19)31)15-9-7-14(8-10-15)17-11-12-33-28-17/h3-13,19-20H,1-2H3 ZUVDHEZQTNDKFX-UHFFFAOYSA-N 105787 US8575197, I-297 P2X purinoceptor 3 Homo sapiens 220 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105787 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105787&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808425 174008098 ZINC96176649 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224287 COCCOc1ccccc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccon1 InChI=1S/C26H26N2O6/c1-16(2)24(29)22-23(19-6-4-5-7-21(19)33-15-14-32-3)28(26(31)25(22)30)18-10-8-17(9-11-18)20-12-13-34-27-20/h4-13,16,22-23H,14-15H2,1-3H3 PNGWRFAKPYKBPW-UHFFFAOYSA-N 105788 US8575197, I-298 P2X purinoceptor 3 Homo sapiens 269 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105788 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105788&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808426 174008099 ZINC96176650 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224288 CC(C)Oc1ccccc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccsc1 InChI=1S/C27H27NO4S/c1-16(2)25(29)23-24(21-7-5-6-8-22(21)32-17(3)4)28(27(31)26(23)30)20-11-9-18(10-12-20)19-13-14-33-15-19/h5-17,23-24H,1-4H3 VJANXHHZFWWTEA-UHFFFAOYSA-N 105789 US8575197, I-299 P2X purinoceptor 3 Homo sapiens 8 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105789 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105789&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808427 174008100 ZINC96176651 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224289 CC(C)C(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1ccsc1)c1ccccc1C(F)(F)F InChI=1S/C25H20F3NO3S/c1-14(2)22(30)20-21(18-5-3-4-6-19(18)25(26,27)28)29(24(32)23(20)31)17-9-7-15(8-10-17)16-11-12-33-13-16/h3-14,20-21H,1-2H3 ZLNUBSPPOVPZQU-UHFFFAOYSA-N 105790 US8575197, I-300 P2X purinoceptor 3 Homo sapiens 114 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105790 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105790&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808428 174008101 ZINC96176652 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224290 CC(C)C(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1ccsc1)c1ccccc1OC(F)F InChI=1S/C25H21F2NO4S/c1-14(2)22(29)20-21(18-5-3-4-6-19(18)32-25(26)27)28(24(31)23(20)30)17-9-7-15(8-10-17)16-11-12-33-13-16/h3-14,20-21,25H,1-2H3 ZXHZLNGNLJWJTF-UHFFFAOYSA-N 105791 US8575197, I-301 P2X purinoceptor 3 Homo sapiens 18 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105791 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105791&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808429 174008102 ZINC96176653 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224291 CC(C)C(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1ccsc1)c1ccccc1OC(F)(F)F InChI=1S/C25H20F3NO4S/c1-14(2)22(30)20-21(18-5-3-4-6-19(18)33-25(26,27)28)29(24(32)23(20)31)17-9-7-15(8-10-17)16-11-12-34-13-16/h3-14,20-21H,1-2H3 KXOGMYDFQLRQOS-UHFFFAOYSA-N 105792 US8575197, I-302 P2X purinoceptor 3 Homo sapiens 34 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105792 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105792&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808430 174008103 ZINC96176654 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224292 COCc1ccccc1C1C(C(=O)CC(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccc(C)s1 InChI=1S/C28H29NO4S/c1-17(2)15-23(30)25-26(22-8-6-5-7-20(22)16-33-4)29(28(32)27(25)31)21-12-10-19(11-13-21)24-14-9-18(3)34-24/h5-14,17,25-26H,15-16H2,1-4H3 YFKHUGFJDPJSKI-UHFFFAOYSA-N 105793 US8575197, I-303 P2X purinoceptor 3 Homo sapiens 31 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105793 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105793&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808431 174008104 ZINC96176655 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224293 COCCOc1ccccc1C1C(C(=O)CC(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccc(C)s1 InChI=1S/C29H31NO5S/c1-18(2)17-23(31)26-27(22-7-5-6-8-24(22)35-16-15-34-4)30(29(33)28(26)32)21-12-10-20(11-13-21)25-14-9-19(3)36-25/h5-14,18,26-27H,15-17H2,1-4H3 HKHJBNPXHHONJN-UHFFFAOYSA-N 105794 US8575197, I-304 P2X purinoceptor 3 Homo sapiens 21 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105794 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105794&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808432 174008105 ZINC96176656 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224294 COCOc1ccccc1C1C(C(=O)CC(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccc(C)s1 InChI=1S/C28H29NO5S/c1-17(2)15-22(30)25-26(21-7-5-6-8-23(21)34-16-33-4)29(28(32)27(25)31)20-12-10-19(11-13-20)24-14-9-18(3)35-24/h5-14,17,25-26H,15-16H2,1-4H3 CLBVDCWGAYSOBN-UHFFFAOYSA-N 105795 US8575197, I-305 P2X purinoceptor 3 Homo sapiens 20 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105795 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105795&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808433 174008106 ZINC96176657 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224295 CC(C)CC(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1ccon1)c1ccccc1OC(C)C InChI=1S/C27H28N2O5/c1-16(2)15-22(30)24-25(20-7-5-6-8-23(20)34-17(3)4)29(27(32)26(24)31)19-11-9-18(10-12-19)21-13-14-33-28-21/h5-14,16-17,24-25H,15H2,1-4H3 VFWANLNSRLCXMF-UHFFFAOYSA-N 105796 US8575197, I-306 P2X purinoceptor 3 Homo sapiens 54 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105796 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105796&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808434 174008107 ZINC96176658 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224296 CC(C)CC(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1ccon1)c1ccccc1OC(F)F InChI=1S/C25H22F2N2O5/c1-14(2)13-19(30)21-22(17-5-3-4-6-20(17)34-25(26)27)29(24(32)23(21)31)16-9-7-15(8-10-16)18-11-12-33-28-18/h3-12,14,21-22,25H,13H2,1-2H3 CQGTYPCRESGDRZ-UHFFFAOYSA-N 105797 US8575197, I-307 P2X purinoceptor 3 Homo sapiens 158 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105797 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105797&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808435 174008108 ZINC96176659 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224297 CC(C)CC(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1ccon1)c1ccccc1OC(F)(F)F InChI=1S/C25H21F3N2O5/c1-14(2)13-19(31)21-22(17-5-3-4-6-20(17)35-25(26,27)28)30(24(33)23(21)32)16-9-7-15(8-10-16)18-11-12-34-29-18/h3-12,14,21-22H,13H2,1-2H3 ZNTYKWOMPCWELZ-UHFFFAOYSA-N 105798 US8575197, I-308 P2X purinoceptor 3 Homo sapiens 193 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105798 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105798&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808436 174008109 ZINC96176660 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224298 COCCOc1ccccc1C1C(C(=O)CC(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccon1 InChI=1S/C27H28N2O6/c1-17(2)16-22(30)24-25(20-6-4-5-7-23(20)34-15-14-33-3)29(27(32)26(24)31)19-10-8-18(9-11-19)21-12-13-35-28-21/h4-13,17,24-25H,14-16H2,1-3H3 XDZLGYYPNGLJMM-UHFFFAOYSA-N 105799 US8575197, I-309 P2X purinoceptor 3 Homo sapiens 182 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105799 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105799&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808437 174008110 ZINC96176661 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224299 COCc1ccccc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1noc(C)n1 InChI=1S/C25H25N3O5/c1-14(2)22(29)20-21(19-8-6-5-7-17(19)13-32-4)28(25(31)23(20)30)18-11-9-16(10-12-18)24-26-15(3)33-27-24/h5-12,14,20-21H,13H2,1-4H3 ZCAWJZZMAJUESN-UHFFFAOYSA-N 105800 US8575197, I-310 P2X purinoceptor 3 Homo sapiens 337 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105800 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105800&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808438 174008111 ZINC96176662 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224300 COCOc1ccccc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1noc(C)n1 InChI=1S/C25H25N3O6/c1-14(2)22(29)20-21(18-7-5-6-8-19(18)33-13-32-4)28(25(31)23(20)30)17-11-9-16(10-12-17)24-26-15(3)34-27-24/h5-12,14,20-21H,13H2,1-4H3 ZPAPOHDKKRFTJL-UHFFFAOYSA-N 105801 US8575197, I-311 P2X purinoceptor 3 Homo sapiens 121 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105801 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105801&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808439 174008112 ZINC96176663 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224301 CC(C)Oc1ccccc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1noc(C)n1 InChI=1S/C26H27N3O5/c1-14(2)23(30)21-22(19-8-6-7-9-20(19)33-15(3)4)29(26(32)24(21)31)18-12-10-17(11-13-18)25-27-16(5)34-28-25/h6-15,21-22H,1-5H3 PRVMAFALULOHPT-UHFFFAOYSA-N 105802 US8575197, I-312 P2X purinoceptor 3 Homo sapiens 54 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105802 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105802&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808440 174008113 ZINC96176664 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224302 CC(C)C(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1noc(C)n1)c1ccccc1OC(F)F InChI=1S/C24H21F2N3O5/c1-12(2)20(30)18-19(16-6-4-5-7-17(16)33-24(25)26)29(23(32)21(18)31)15-10-8-14(9-11-15)22-27-13(3)34-28-22/h4-12,18-19,24H,1-3H3 NPRVBUVVFYCWEC-UHFFFAOYSA-N 105803 US8575197, I-313 P2X purinoceptor 3 Homo sapiens 320 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105803 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105803&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808441 174008114 ZINC96176665 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224303 CC(C)C(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1noc(C)n1)c1ccccc1OC(F)(F)F InChI=1S/C24H20F3N3O5/c1-12(2)20(31)18-19(16-6-4-5-7-17(16)34-24(25,26)27)30(23(33)21(18)32)15-10-8-14(9-11-15)22-28-13(3)35-29-22/h4-12,18-19H,1-3H3 OKGLRRWUCOZLDR-UHFFFAOYSA-N 105804 US8575197, I-314 P2X purinoceptor 3 Homo sapiens 329 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105804 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105804&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808442 174008115 ZINC96176666 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224304 COCc1ccccc1C1C(C(=O)CC(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1noc(C)n1 InChI=1S/C26H27N3O5/c1-15(2)13-21(30)22-23(20-8-6-5-7-18(20)14-33-4)29(26(32)24(22)31)19-11-9-17(10-12-19)25-27-16(3)34-28-25/h5-12,15,22-23H,13-14H2,1-4H3 IVUPFFCTUPRPRN-UHFFFAOYSA-N 105805 US8575197, I-315 P2X purinoceptor 3 Homo sapiens 252 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105805 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105805&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808443 174008116 ZINC96176667 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224305 COCOc1ccccc1C1C(C(=O)CC(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1noc(C)n1 InChI=1S/C26H27N3O6/c1-15(2)13-20(30)22-23(19-7-5-6-8-21(19)34-14-33-4)29(26(32)24(22)31)18-11-9-17(10-12-18)25-27-16(3)35-28-25/h5-12,15,22-23H,13-14H2,1-4H3 PYCXSWQKCWSRJO-UHFFFAOYSA-N 105806 US8575197, I-316 P2X purinoceptor 3 Homo sapiens 130 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105806 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105806&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808444 174008117 ZINC96176668 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224306 CC(C)CC(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1noc(C)n1)c1ccccc1OC(C)C InChI=1S/C27H29N3O5/c1-15(2)14-21(31)23-24(20-8-6-7-9-22(20)34-16(3)4)30(27(33)25(23)32)19-12-10-18(11-13-19)26-28-17(5)35-29-26/h6-13,15-16,23-24H,14H2,1-5H3 VYMDLLSRYYGWOI-UHFFFAOYSA-N 105807 US8575197, I-317 P2X purinoceptor 3 Homo sapiens 73 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105807 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105807&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808445 174008118 ZINC96176669 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224307 CC(C)CC(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1noc(C)n1)c1ccccc1OC(F)F InChI=1S/C25H23F2N3O5/c1-13(2)12-18(31)20-21(17-6-4-5-7-19(17)34-25(26)27)30(24(33)22(20)32)16-10-8-15(9-11-16)23-28-14(3)35-29-23/h4-11,13,20-21,25H,12H2,1-3H3 RMOFAQKRCLUTJW-UHFFFAOYSA-N 105808 US8575197, I-318 P2X purinoceptor 3 Homo sapiens 328 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105808 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105808&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808446 174008119 ZINC96176670 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224308 CC(C)CC(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1noc(C)n1)c1ccccc1OC(F)(F)F InChI=1S/C25H22F3N3O5/c1-13(2)12-18(32)20-21(17-6-4-5-7-19(17)35-25(26,27)28)31(24(34)22(20)33)16-10-8-15(9-11-16)23-29-14(3)36-30-23/h4-11,13,20-21H,12H2,1-3H3 KXGCWBISJYTUDF-UHFFFAOYSA-N 105809 US8575197, I-319 P2X purinoceptor 3 Homo sapiens 222 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105809 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105809&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808447 174008120 ZINC96176671 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224309 COc1ncccc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1csc(C)c1 InChI=1S/C25H24N2O4S/c1-14(2)22(28)20-21(19-6-5-11-26-24(19)31-4)27(25(30)23(20)29)18-9-7-16(8-10-18)17-12-15(3)32-13-17/h5-14,20-21H,1-4H3 JMKFIYHFYVINGZ-UHFFFAOYSA-N 105810 US8575197, I-320 P2X purinoceptor 3 Homo sapiens 274 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105810 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105810&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808448 174008121 ZINC96176672 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224310 CC(C)C(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1csc(C)c1)c1ccccc1OC(F)F InChI=1S/C26H23F2NO4S/c1-14(2)23(30)21-22(19-6-4-5-7-20(19)33-26(27)28)29(25(32)24(21)31)18-10-8-16(9-11-18)17-12-15(3)34-13-17/h4-14,21-22,26H,1-3H3 HMPFXWFMYOPZKQ-UHFFFAOYSA-N 105811 US8575197, I-321 P2X purinoceptor 3 Homo sapiens 70 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105811 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105811&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808449 174008122 ZINC96176673 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224311 CC(C)C(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1csc(C)c1)c1ccccc1OC(F)(F)F InChI=1S/C26H22F3NO4S/c1-14(2)23(31)21-22(19-6-4-5-7-20(19)34-26(27,28)29)30(25(33)24(21)32)18-10-8-16(9-11-18)17-12-15(3)35-13-17/h4-14,21-22H,1-3H3 AGQIFRRDOLHEFN-UHFFFAOYSA-N 105812 US8575197, I-322 P2X purinoceptor 3 Homo sapiens 102 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105812 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105812&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808450 174008123 ZINC96176674 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224312 CC(C)CC(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1ccon1)c1ccccc1OCCO InChI=1S/C26H26N2O6/c1-16(2)15-21(30)23-24(19-5-3-4-6-22(19)33-14-12-29)28(26(32)25(23)31)18-9-7-17(8-10-18)20-11-13-34-27-20/h3-11,13,16,23-24,29H,12,14-15H2,1-2H3 RTEFHYFCPZKXAZ-UHFFFAOYSA-N 105813 US8575197, I-323 P2X purinoceptor 3 Homo sapiens 310 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105813 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105813&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808451 174008124 ZINC96176675 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224313 COCc1ncccc1C1C(C(=O)CC(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccsc1 InChI=1S/C26H26N2O4S/c1-16(2)13-22(29)23-24(20-5-4-11-27-21(20)14-32-3)28(26(31)25(23)30)19-8-6-17(7-9-19)18-10-12-33-15-18/h4-12,15-16,23-24H,13-14H2,1-3H3 XUBWTKXRLKFZEM-UHFFFAOYSA-N 105814 US8575197, I-324 P2X purinoceptor 3 Homo sapiens 109 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105814 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105814&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808452 174008125 ZINC96176676 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224314 COc1cc(F)ccc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccsc1 InChI=1S/C25H22FNO4S/c1-14(2)23(28)21-22(19-9-6-17(26)12-20(19)31-3)27(25(30)24(21)29)18-7-4-15(5-8-18)16-10-11-32-13-16/h4-14,21-22H,1-3H3 GIWSWILVYLQLQK-UHFFFAOYSA-N 105815 US8575197, I-325 P2X purinoceptor 3 Homo sapiens 18 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105815 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105815&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808453 174008126 ZINC96176677 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224315 COc1cc(F)ccc1C1C(C(=O)CC(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccsc1 InChI=1S/C26H24FNO4S/c1-15(2)12-21(29)23-24(20-9-6-18(27)13-22(20)32-3)28(26(31)25(23)30)19-7-4-16(5-8-19)17-10-11-33-14-17/h4-11,13-15,23-24H,12H2,1-3H3 IVVXMIYXZWBHLE-UHFFFAOYSA-N 105816 US8575197, I-326 P2X purinoceptor 3 Homo sapiens 27 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105816 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105816&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808454 174008127 ZINC96176678 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224316 COc1ccccc1C1C(C(=O)CC(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccc(C)s1 InChI=1S/C27H27NO4S/c1-16(2)15-21(29)24-25(20-7-5-6-8-22(20)32-4)28(27(31)26(24)30)19-12-10-18(11-13-19)23-14-9-17(3)33-23/h5-14,16,24-25H,15H2,1-4H3 ZARBBPVJSASOHM-UHFFFAOYSA-N 105817 US8575197, I-327 P2X purinoceptor 3 Homo sapiens 93 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105817 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105817&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808455 174008128 ZINC96176679 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224317 CC(C)CC(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1ccc(C)s1)c1ccccc1OCCO InChI=1S/C28H29NO5S/c1-17(2)16-22(31)25-26(21-6-4-5-7-23(21)34-15-14-30)29(28(33)27(25)32)20-11-9-19(10-12-20)24-13-8-18(3)35-24/h4-13,17,25-26,30H,14-16H2,1-3H3 BZCSSUZSKULUBX-UHFFFAOYSA-N 105818 US8575197, I-328 P2X purinoceptor 3 Homo sapiens 65 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105818 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105818&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808456 174008129 ZINC96176680 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224318 COC1=C(C(N(C1=O)c1ccc(cc1)-c1ccc(C)s1)c1ccccc1OC)C(=O)CC(C)C InChI=1S/C28H29NO4S/c1-17(2)16-22(30)25-26(21-8-6-7-9-23(21)32-4)29(28(31)27(25)33-5)20-13-11-19(12-14-20)24-15-10-18(3)34-24/h6-15,17,26H,16H2,1-5H3 MTUCAQBDKAYILG-UHFFFAOYSA-N 105819 US8575197, I-329 P2X purinoceptor 3 Homo sapiens 578 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105819 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105819&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58366028 174008130 ZINC96176681 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224319 CC(C)CC(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1ccsc1)c1ccccc1OC(F)(F)F InChI=1S/C26H22F3NO4S/c1-15(2)13-20(31)22-23(19-5-3-4-6-21(19)34-26(27,28)29)30(25(33)24(22)32)18-9-7-16(8-10-18)17-11-12-35-14-17/h3-12,14-15,22-23H,13H2,1-2H3 WSHDHVOHIMZCSW-UHFFFAOYSA-N 105820 US8575197, I-330 P2X purinoceptor 3 Homo sapiens 70 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105820 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105820&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808457 174008131 ZINC96176682 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224320 COc1ccc(CC(=O)C2C(C3CCCCC3)N(C(=O)C2=O)c2ccc(cc2)-c2noc(C)n2)cc1 InChI=1S/C28H29N3O5/c1-17-29-27(30-36-17)20-10-12-21(13-11-20)31-25(19-6-4-3-5-7-19)24(26(33)28(31)34)23(32)16-18-8-14-22(35-2)15-9-18/h8-15,19,24-25H,3-7,16H2,1-2H3 GHMLGCILUJTECF-UHFFFAOYSA-N 105821 US8575197, I-331 P2X purinoceptor 3 Homo sapiens 722 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105821 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105821&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808458 174008132 ZINC96176683 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224321 COc1ccccc1C1C(C(=O)C(=O)N1c1ccc(cc1)-c1ccc(C)o1)S(C)(=O)=O InChI=1S/C23H21NO6S/c1-14-8-13-18(30-14)15-9-11-16(12-10-15)24-20(17-6-4-5-7-19(17)29-2)22(31(3,27)28)21(25)23(24)26/h4-13,20,22H,1-3H3 SUDGVLGETKIDTK-UHFFFAOYSA-N 105958 US8575197, I-468 P2X purinoceptor 3 Homo sapiens 467 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105958 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105958&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808581 174008269 ZINC96176819 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224322 Cc1nc(no1)-c1ccc(cc1)N=C1CC(C2CCCCC2)N(C1=O)c1ccc(cc1)-c1noc(C)n1 InChI=1S/C28H28N6O3/c1-17-29-26(32-36-17)20-8-12-22(13-9-20)31-24-16-25(19-6-4-3-5-7-19)34(28(24)35)23-14-10-21(11-15-23)27-30-18(2)37-33-27/h8-15,19,25H,3-7,16H2,1-2H3 IFKLQCDQQTZTDO-UHFFFAOYSA-N 105959 US8575197, I-469 P2X purinoceptor 3 Homo sapiens 646 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105959 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105959&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808582 174008270 ZINC96176820 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224323 CCOC(=O)C(C)(C)C(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1csc(C)c1)c1ccccc1OC InChI=1S/C29H29NO6S/c1-6-36-28(34)29(3,4)26(32)23-24(21-9-7-8-10-22(21)35-5)30(27(33)25(23)31)20-13-11-18(12-14-20)19-15-17(2)37-16-19/h7-16,23-24H,6H2,1-5H3 YKGYDTALUZSYBL-UHFFFAOYSA-N 105960 US8575197, I-470 P2X purinoceptor 3 Homo sapiens 972 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105960 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105960&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808583 174008271 ZINC96176821 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224324 COCCCOc1ncccc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccc(C)o1 InChI=1S/C28H30N2O6/c1-17(2)25(31)23-24(21-7-5-14-29-27(21)35-16-6-15-34-4)30(28(33)26(23)32)20-11-9-19(10-12-20)22-13-8-18(3)36-22/h5,7-14,17,23-24H,6,15-16H2,1-4H3 IQZOFKOKBNLZHH-UHFFFAOYSA-N 105961 US8575197, I-471 P2X purinoceptor 3 Homo sapiens 19 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105961 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105961&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808584 174008272 ZINC96176822 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224325 COCCOc1ncccc1[C@@H]1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccc(C)s1 InChI=1S/C27H28N2O5S/c1-16(2)24(30)22-23(20-6-5-13-28-26(20)34-15-14-33-4)29(27(32)25(22)31)19-10-8-18(9-11-19)21-12-7-17(3)35-21/h5-13,16,22-23H,14-15H2,1-4H3/t22?,23-/m1/s1 QIXPGMREOHTNEW-OZAIVSQSSA-N 105962 US8575197, I-472 P2X purinoceptor 3 Homo sapiens 7 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105962 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105962&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808585 174008273 ZINC96176823 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224326 COc1ccccc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(SC)cc1 InChI=1S/C22H23NO4S/c1-13(2)20(24)18-19(16-7-5-6-8-17(16)27-3)23(22(26)21(18)25)14-9-11-15(28-4)12-10-14/h5-13,18-19H,1-4H3 LRHBKNPAGARXSH-UHFFFAOYSA-N 105963 US8575197, I-473 P2X purinoceptor 3 Homo sapiens 182 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105963 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105963&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808586 174008274 ZINC96176824 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224327 CSc1ccc(cc1)N1C(C(C(=O)C(C)C)C(=O)C1=O)c1ccccc1OC(C)C InChI=1S/C24H27NO4S/c1-14(2)22(26)20-21(18-8-6-7-9-19(18)29-15(3)4)25(24(28)23(20)27)16-10-12-17(30-5)13-11-16/h6-15,20-21H,1-5H3 APNKHTLONHFLJS-UHFFFAOYSA-N 105964 US8575197, I-474 P2X purinoceptor 3 Homo sapiens 71 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105964 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105964&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808587 174008275 ZINC96176825 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224328 COCCOc1ccccc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(SC)cc1 InChI=1S/C24H27NO5S/c1-15(2)22(26)20-21(18-7-5-6-8-19(18)30-14-13-29-3)25(24(28)23(20)27)16-9-11-17(31-4)12-10-16/h5-12,15,20-21H,13-14H2,1-4H3 UBRKIHUMTQKGPQ-UHFFFAOYSA-N 105965 US8575197, I-475 P2X purinoceptor 3 Homo sapiens 181 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105965 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105965&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808588 174008276 ZINC96176826 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224329 CSc1ccc(cc1)N1C(C(C(=O)C(C)C)C(=O)C1=O)c1ccccc1OCCCO InChI=1S/C24H27NO5S/c1-15(2)22(27)20-21(18-7-4-5-8-19(18)30-14-6-13-26)25(24(29)23(20)28)16-9-11-17(31-3)12-10-16/h4-5,7-12,15,20-21,26H,6,13-14H2,1-3H3 XPCGFASPIILZMD-UHFFFAOYSA-N 105966 US8575197, I-476 P2X purinoceptor 3 Homo sapiens 51 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105966 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105966&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808589 174008277 ZINC96176827 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224330 COCc1ccccc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(SC)cc1 InChI=1S/C23H25NO4S/c1-14(2)21(25)19-20(18-8-6-5-7-15(18)13-28-3)24(23(27)22(19)26)16-9-11-17(29-4)12-10-16/h5-12,14,19-20H,13H2,1-4H3 ULMJTQRLTUJPJN-UHFFFAOYSA-N 105967 US8575197, I-477 P2X purinoceptor 3 Homo sapiens 477 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105967 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105967&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808590 174008278 ZINC96176828 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224331 CC(C)C(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1ccc(C)o1)c1cccnc1OCCCO InChI=1S/C27H28N2O6/c1-16(2)24(31)22-23(20-6-4-13-28-26(20)34-15-5-14-30)29(27(33)25(22)32)19-10-8-18(9-11-19)21-12-7-17(3)35-21/h4,6-13,16,22-23,30H,5,14-15H2,1-3H3 WLLHZBMLGAEZOA-UHFFFAOYSA-N 105968 US8575197, I-478 P2X purinoceptor 3 Homo sapiens 34 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105968 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105968&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808591 174008279 ZINC96176829 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224332 CC(C)Oc1ncccc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccc(C)o1 InChI=1S/C27H28N2O5/c1-15(2)24(30)22-23(20-7-6-14-28-26(20)33-16(3)4)29(27(32)25(22)31)19-11-9-18(10-12-19)21-13-8-17(5)34-21/h6-16,22-23H,1-5H3 YGLUIKASCANTOX-UHFFFAOYSA-N 105969 US8575197, I-479 P2X purinoceptor 3 Homo sapiens 10 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105969 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105969&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808592 174008280 ZINC96176830 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224333 COc1ccc(cc1)C(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1cc(C)on1)c1ccccc1OC InChI=1S/C29H24N2O6/c1-17-16-23(30-37-17)18-8-12-20(13-9-18)31-26(22-6-4-5-7-24(22)36-3)25(28(33)29(31)34)27(32)19-10-14-21(35-2)15-11-19/h4-16,25-26H,1-3H3 YWKQDCWUSYLIBF-UHFFFAOYSA-N 105970 US8575197, I-480 P2X purinoceptor 3 Homo sapiens 42 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105970 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105970&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808593 174008281 ZINC96176831 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224334 COCCOc1ccccc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1cc(C)on1 InChI=1S/C27H28N2O6/c1-16(2)25(30)23-24(20-7-5-6-8-22(20)34-14-13-33-4)29(27(32)26(23)31)19-11-9-18(10-12-19)21-15-17(3)35-28-21/h5-12,15-16,23-24H,13-14H2,1-4H3 QTJOJPURCJCXBX-UHFFFAOYSA-N 105971 US8575197, I-481 P2X purinoceptor 3 Homo sapiens 378 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105971 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105971&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808594 174008282 ZINC96176832 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224335 O=C1C(C(C2CCCCC2)N(C1=O)c1ccc(cc1)-c1ccon1)S(=O)(=O)c1ccccc1 InChI=1S/C25H24N2O5S/c28-23-24(33(30,31)20-9-5-2-6-10-20)22(18-7-3-1-4-8-18)27(25(23)29)19-13-11-17(12-14-19)21-15-16-32-26-21/h2,5-6,9-16,18,22,24H,1,3-4,7-8H2 BUKRPEXAGIAUJK-UHFFFAOYSA-N 105972 US8575197, I-482 P2X purinoceptor 3 Homo sapiens 333 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105972 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105972&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808595 174008283 ZINC96176833 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224336 CC(C)C(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1ccc(C)o1)c1cccnc1OCCO InChI=1S/C26H26N2O6/c1-15(2)23(30)21-22(19-5-4-12-27-25(19)33-14-13-29)28(26(32)24(21)31)18-9-7-17(8-10-18)20-11-6-16(3)34-20/h4-12,15,21-22,29H,13-14H2,1-3H3 BMKKRIGAYCXIHA-UHFFFAOYSA-N 105973 US8575197, I-483 P2X purinoceptor 3 Homo sapiens 89 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105973 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105973&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808596 174008284 ZINC96176834 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224337 COCCCOc1ccccc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(SC)cc1 InChI=1S/C25H29NO5S/c1-16(2)23(27)21-22(19-8-5-6-9-20(19)31-15-7-14-30-3)26(25(29)24(21)28)17-10-12-18(32-4)13-11-17/h5-6,8-13,16,21-22H,7,14-15H2,1-4H3 WWDCINWWJYRJFZ-UHFFFAOYSA-N 105974 US8575197, I-484 P2X purinoceptor 3 Homo sapiens 91 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105974 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105974&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808597 174008285 ZINC96176835 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224338 COCCOc1ncccc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(SC)cc1 InChI=1S/C23H26N2O5S/c1-14(2)20(26)18-19(17-6-5-11-24-22(17)30-13-12-29-3)25(23(28)21(18)27)15-7-9-16(31-4)10-8-15/h5-11,14,18-19H,12-13H2,1-4H3 VVUKDICEGXZZHS-UHFFFAOYSA-N 105975 US8575197, I-485 P2X purinoceptor 3 Homo sapiens 218 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105975 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105975&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808598 174008286 ZINC96176836 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224339 CC(C)C(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1ccc(C)o1)c1ccccc1N1CCOCC1 InChI=1S/C29H30N2O5/c1-18(2)27(32)25-26(22-6-4-5-7-23(22)30-14-16-35-17-15-30)31(29(34)28(25)33)21-11-9-20(10-12-21)24-13-8-19(3)36-24/h4-13,18,25-26H,14-17H2,1-3H3 ASXIHKMIYBGFTI-UHFFFAOYSA-N 105976 US8575197, I-486 P2X purinoceptor 3 Homo sapiens 4 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105976 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105976&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808599 174008287 ZINC96176837 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224340 CC(C)C(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1noc(C)n1)c1ccccc1N1CCOCC1 InChI=1S/C27H28N4O5/c1-16(2)24(32)22-23(20-6-4-5-7-21(20)30-12-14-35-15-13-30)31(27(34)25(22)33)19-10-8-18(9-11-19)26-28-17(3)36-29-26/h4-11,16,22-23H,12-15H2,1-3H3 TXJZZCKBGCTMFI-UHFFFAOYSA-N 105977 US8575197, I-487 P2X purinoceptor 3 Homo sapiens 167 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105977 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105977&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808600 174008288 ZINC96176838 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224341 CC(C)CC(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1noc(C)n1)c1ccccc1N1CCOCC1 InChI=1S/C28H30N4O5/c1-17(2)16-23(33)24-25(21-6-4-5-7-22(21)31-12-14-36-15-13-31)32(28(35)26(24)34)20-10-8-19(9-11-20)27-29-18(3)37-30-27/h4-11,17,24-25H,12-16H2,1-3H3 MKEQDRVBAFRSIA-UHFFFAOYSA-N 105978 US8575197, I-488 P2X purinoceptor 3 Homo sapiens 67 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105978 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105978&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808601 174008289 ZINC96176839 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224342 COCCCOc1ccccc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccsc1 InChI=1S/C28H29NO5S/c1-18(2)26(30)24-25(22-7-4-5-8-23(22)34-15-6-14-33-3)29(28(32)27(24)31)21-11-9-19(10-12-21)20-13-16-35-17-20/h4-5,7-13,16-18,24-25H,6,14-15H2,1-3H3 BXKANXOXPFKQIB-UHFFFAOYSA-N 105979 US8575197, I-489 P2X purinoceptor 3 Homo sapiens 6 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105979 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105979&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808602 174008290 ZINC96176840 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224343 COCCCOc1ccccc1C1C(C(=O)CC(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccsc1 InChI=1S/C29H31NO5S/c1-19(2)17-24(31)26-27(23-7-4-5-8-25(23)35-15-6-14-34-3)30(29(33)28(26)32)22-11-9-20(10-12-22)21-13-16-36-18-21/h4-5,7-13,16,18-19,26-27H,6,14-15,17H2,1-3H3 MQKYJLVLBNNQHJ-UHFFFAOYSA-N 105980 US8575197, I-490 P2X purinoceptor 3 Homo sapiens 17 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105980 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105980&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808603 174008291 ZINC96176841 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224344 COCCCOc1ccccc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1noc(C)n1 InChI=1S/C27H29N3O6/c1-16(2)24(31)22-23(20-8-5-6-9-21(20)35-15-7-14-34-4)30(27(33)25(22)32)19-12-10-18(11-13-19)26-28-17(3)36-29-26/h5-6,8-13,16,22-23H,7,14-15H2,1-4H3 OAYMYCUDILBVKA-UHFFFAOYSA-N 105981 US8575197, I-491 P2X purinoceptor 3 Homo sapiens 155 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105981 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105981&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808604 174008292 ZINC96176842 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224345 COCCCOc1ccccc1C1C(C(=O)CC(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1noc(C)n1 InChI=1S/C28H31N3O6/c1-17(2)16-22(32)24-25(21-8-5-6-9-23(21)36-15-7-14-35-4)31(28(34)26(24)33)20-12-10-19(11-13-20)27-29-18(3)37-30-27/h5-6,8-13,17,24-25H,7,14-16H2,1-4H3 MASDIXIQUWEPRS-UHFFFAOYSA-N 105982 US8575197, I-492 P2X purinoceptor 3 Homo sapiens 104 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105982 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105982&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808605 174008293 ZINC96176843 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224346 CC(C)C(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1ccc(C)o1)c1ccccc1CC(=O)N(C)C InChI=1S/C29H30N2O5/c1-17(2)27(33)25-26(22-9-7-6-8-20(22)16-24(32)30(4)5)31(29(35)28(25)34)21-13-11-19(12-14-21)23-15-10-18(3)36-23/h6-15,17,25-26H,16H2,1-5H3 XKPPCNRXBMEQOW-UHFFFAOYSA-N 105983 US8575197, I-493 P2X purinoceptor 3 Homo sapiens 105 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105983 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105983&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808606 174008294 ZINC96176844 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224347 CCN(C)C(=O)c1ccccc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1csc(C)c1 InChI=1S/C29H30N2O4S/c1-6-30(5)28(34)23-10-8-7-9-22(23)25-24(26(32)17(2)3)27(33)29(35)31(25)21-13-11-19(12-14-21)20-15-18(4)36-16-20/h7-17,24-25H,6H2,1-5H3 LDGPBAOTRNHWPT-UHFFFAOYSA-N 105984 US8575197, I-494 P2X purinoceptor 3 Homo sapiens 53 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105984 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105984&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808607 174008295 ZINC96176845 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224348 CCN(C)C(=O)c1ccccc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccc(C)o1 InChI=1S/C29H30N2O5/c1-6-30(5)28(34)22-10-8-7-9-21(22)25-24(26(32)17(2)3)27(33)29(35)31(25)20-14-12-19(13-15-20)23-16-11-18(4)36-23/h7-17,24-25H,6H2,1-5H3 IJYGZJSTHYLUHS-UHFFFAOYSA-N 105985 US8575197, I-495 P2X purinoceptor 3 Homo sapiens 59 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105985 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105985&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808608 174008296 ZINC96176846 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224349 COCCN(C)C(=O)c1ccccc1C1C(C(=O)CC(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccc(C)o1 InChI=1S/C31H34N2O6/c1-19(2)18-25(34)27-28(23-8-6-7-9-24(23)30(36)32(4)16-17-38-5)33(31(37)29(27)35)22-13-11-21(12-14-22)26-15-10-20(3)39-26/h6-15,19,27-28H,16-18H2,1-5H3 UVPMJLLOTIRJPA-UHFFFAOYSA-N 105986 US8575197, I-496 P2X purinoceptor 3 Homo sapiens 55 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105986 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105986&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808609 174008297 ZINC96176847 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224350 COCCN(C)C(=O)c1ccccc1C1C(C(=O)CC(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1csc(C)c1 InChI=1S/C31H34N2O5S/c1-19(2)16-26(34)27-28(24-8-6-7-9-25(24)30(36)32(4)14-15-38-5)33(31(37)29(27)35)23-12-10-21(11-13-23)22-17-20(3)39-18-22/h6-13,17-19,27-28H,14-16H2,1-5H3 UASMMMRYYVQTHF-UHFFFAOYSA-N 105987 US8575197, I-497 P2X purinoceptor 3 Homo sapiens 36 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105987 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105987&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808610 174008298 ZINC96176848 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224351 CC(C)CC(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1ccsc1)c1ccccc1OCC(CO)CO InChI=1S/C29H31NO6S/c1-18(2)13-24(33)26-27(23-5-3-4-6-25(23)36-16-19(14-31)15-32)30(29(35)28(26)34)22-9-7-20(8-10-22)21-11-12-37-17-21/h3-12,17-19,26-27,31-32H,13-16H2,1-2H3 BQVNRSZEHRLEDC-UHFFFAOYSA-N 105988 US8575197, I-498 P2X purinoceptor 3 Homo sapiens 8 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105988 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105988&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808611 174008299 ZINC96176849 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224352 Cc1nc(no1)-c1ccc(cc1)N1C(C(C(=O)C1=O)S(=O)(=O)c1ccccc1)C1CCCCC1 InChI=1S/C25H25N3O5S/c1-16-26-24(27-33-16)18-12-14-19(15-13-18)28-21(17-8-4-2-5-9-17)23(22(29)25(28)30)34(31,32)20-10-6-3-7-11-20/h3,6-7,10-15,17,21,23H,2,4-5,8-9H2,1H3 XZKAXMFBAOMQCC-UHFFFAOYSA-N 105989 US8575197, I-499 P2X purinoceptor 3 Homo sapiens 398 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105989 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105989&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808612 174008300 ZINC96176850 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224353 CC(C)C(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1csc(C)c1)c1ccccc1OCC1OCCO1 InChI=1S/C29H29NO6S/c1-17(2)27(31)25-26(22-6-4-5-7-23(22)36-15-24-34-12-13-35-24)30(29(33)28(25)32)21-10-8-19(9-11-21)20-14-18(3)37-16-20/h4-11,14,16-17,24-26H,12-13,15H2,1-3H3 AUAWYONOHHUUSF-UHFFFAOYSA-N 105990 US8575197, I-500 P2X purinoceptor 3 Homo sapiens 12 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105990 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105990&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808613 174008301 ZINC96176851 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224354 CC(C)C(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1noc(C)n1)c1ccccc1OCC1OCCO1 InChI=1S/C27H27N3O7/c1-15(2)24(31)22-23(19-6-4-5-7-20(19)36-14-21-34-12-13-35-21)30(27(33)25(22)32)18-10-8-17(9-11-18)26-28-16(3)37-29-26/h4-11,15,21-23H,12-14H2,1-3H3 BQPKHWXTNSWBQZ-UHFFFAOYSA-N 105991 US8575197, I-501 P2X purinoceptor 3 Homo sapiens 52 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105991 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105991&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808614 174008302 ZINC96176852 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224355 CC(C)C(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1noc(C)n1)c1ccccc1OC1CCOCC1 InChI=1S/C28H29N3O6/c1-16(2)25(32)23-24(21-6-4-5-7-22(21)36-20-12-14-35-15-13-20)31(28(34)26(23)33)19-10-8-18(9-11-19)27-29-17(3)37-30-27/h4-11,16,20,23-24H,12-15H2,1-3H3 DJPBURYKJXMQIH-UHFFFAOYSA-N 105992 US8575197, I-502 P2X purinoceptor 3 Homo sapiens 67 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105992 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105992&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808615 174008303 ZINC96176853 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224356 CC(C)C(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1noc(C)n1)c1ccccc1OC1CCCC1 InChI=1S/C28H29N3O5/c1-16(2)25(32)23-24(21-10-6-7-11-22(21)35-20-8-4-5-9-20)31(28(34)26(23)33)19-14-12-18(13-15-19)27-29-17(3)36-30-27/h6-7,10-16,20,23-24H,4-5,8-9H2,1-3H3 BLQPRQHUJGJTLV-UHFFFAOYSA-N 105993 US8575197, I-503 P2X purinoceptor 3 Homo sapiens 17 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105993 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105993&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808616 174008304 ZINC96176854 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224357 CC(C)CC(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1ccc(C)s1)c1cccnc1C(=O)OC(C)C InChI=1S/C29H30N2O5S/c1-16(2)15-22(32)24-26(21-7-6-14-30-25(21)29(35)36-17(3)4)31(28(34)27(24)33)20-11-9-19(10-12-20)23-13-8-18(5)37-23/h6-14,16-17,24,26H,15H2,1-5H3 NZRZNSFGOKNWKN-UHFFFAOYSA-N 105994 US8575197, I-504 P2X purinoceptor 3 Homo sapiens 238 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105994 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105994&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808617 174008305 ZINC96176855 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224358 CC(C)CC(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1csc(C)c1)c1ccccc1C(=O)N1CCOCC1 InChI=1S/C31H32N2O5S/c1-19(2)16-26(34)27-28(24-6-4-5-7-25(24)30(36)32-12-14-38-15-13-32)33(31(37)29(27)35)23-10-8-21(9-11-23)22-17-20(3)39-18-22/h4-11,17-19,27-28H,12-16H2,1-3H3 RQEOHLMIPYZKQS-UHFFFAOYSA-N 105995 US8575197, I-505 P2X purinoceptor 3 Homo sapiens 168 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105995 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105995&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808618 174008306 ZINC96176856 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224359 CC(C)CC(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1ccc(C)o1)c1ccccc1C(=O)N1CCOCC1 InChI=1S/C31H32N2O6/c1-19(2)18-25(34)27-28(23-6-4-5-7-24(23)30(36)32-14-16-38-17-15-32)33(31(37)29(27)35)22-11-9-21(10-12-22)26-13-8-20(3)39-26/h4-13,19,27-28H,14-18H2,1-3H3 RBQWCEFENLSKHJ-UHFFFAOYSA-N 105996 US8575197, I-506 P2X purinoceptor 3 Homo sapiens 112 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105996 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105996&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808619 174008307 ZINC96176857 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224360 CC(C)C(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1csc(C)c1)c1ccccc1S(C)(=O)=O InChI=1S/C26H25NO5S2/c1-15(2)24(28)22-23(20-7-5-6-8-21(20)34(4,31)32)27(26(30)25(22)29)19-11-9-17(10-12-19)18-13-16(3)33-14-18/h5-15,22-23H,1-4H3 ORLNUMLQUNFTTB-UHFFFAOYSA-N 105997 US8575197, I-507 P2X purinoceptor 3 Homo sapiens 101 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105997 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105997&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808620 174008308 ZINC96176858 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224361 CC(C)C(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1noc(C)n1)c1ccccc1OCC#N InChI=1S/C25H22N4O5/c1-14(2)22(30)20-21(18-6-4-5-7-19(18)33-13-12-26)29(25(32)23(20)31)17-10-8-16(9-11-17)24-27-15(3)34-28-24/h4-11,14,20-21H,13H2,1-3H3 PNBRABWYKVOMBZ-UHFFFAOYSA-N 105998 US8575197, I-508 P2X purinoceptor 3 Homo sapiens 133 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105998 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105998&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808621 174008309 ZINC96176859 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224362 CSc1ccc(cc1)N1C(C(C(=O)C(C)C)C(=O)C1=O)c1ccccc1OCC#N InChI=1S/C23H22N2O4S/c1-14(2)21(26)19-20(17-6-4-5-7-18(17)29-13-12-24)25(23(28)22(19)27)15-8-10-16(30-3)11-9-15/h4-11,14,19-20H,13H2,1-3H3 VNGSJGGYWNBUGH-UHFFFAOYSA-N 105999 US8575197, I-509 P2X purinoceptor 3 Homo sapiens 247 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105999 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105999&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808622 174008310 ZINC96176860 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224364 CSc1ccc(cc1)N1C(C(C(=O)CC(C)C)C(=O)C1=O)c1ccccc1OCC#N InChI=1S/C24H24N2O4S/c1-15(2)14-19(27)21-22(18-6-4-5-7-20(18)30-13-12-25)26(24(29)23(21)28)16-8-10-17(31-3)11-9-16/h4-11,15,21-22H,13-14H2,1-3H3 NPXVGTAVYGRYGC-UHFFFAOYSA-N 106001 US8575197, I-511 P2X purinoceptor 3 Homo sapiens 117 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106001 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106001&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808624 174008312 ZINC96176862 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224365 CC(C)Oc1ccccc1C1C(C(=O)C2CCCC2)C(=O)C(=O)N1c1ccc(cc1)-c1ccon1 InChI=1S/C28H28N2O5/c1-17(2)35-23-10-6-5-9-21(23)25-24(26(31)19-7-3-4-8-19)27(32)28(33)30(25)20-13-11-18(12-14-20)22-15-16-34-29-22/h5-6,9-17,19,24-25H,3-4,7-8H2,1-2H3 RENLLWOITRALQN-UHFFFAOYSA-N 106002 US8575197, I-512 P2X purinoceptor 3 Homo sapiens 62 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106002 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106002&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808625 174008313 ZINC96176863 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224366 CC(C)COc1ccccc1C1C(C(=O)C2CCCC2)C(=O)C(=O)N1c1ccc(cc1)-c1ccon1 InChI=1S/C29H30N2O5/c1-18(2)17-35-24-10-6-5-9-22(24)26-25(27(32)20-7-3-4-8-20)28(33)29(34)31(26)21-13-11-19(12-14-21)23-15-16-36-30-23/h5-6,9-16,18,20,25-26H,3-4,7-8,17H2,1-2H3 OUIMQXYKCSCRCP-UHFFFAOYSA-N 106003 US8575197, I-513 P2X purinoceptor 3 Homo sapiens 65 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106003 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106003&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808626 174008314 ZINC96176864 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224367 CN(C)C(=O)c1ccccc1C1C(C(=O)C2CCCC2)C(=O)C(=O)N1c1ccc(cc1)-c1ccsc1 InChI=1S/C29H28N2O4S/c1-30(2)28(34)23-10-6-5-9-22(23)25-24(26(32)19-7-3-4-8-19)27(33)29(35)31(25)21-13-11-18(12-14-21)20-15-16-36-17-20/h5-6,9-17,19,24-25H,3-4,7-8H2,1-2H3 YOZXMYMVGJROFZ-UHFFFAOYSA-N 106004 US8575197, I-514 P2X purinoceptor 3 Homo sapiens 138 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106004 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106004&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808627 174008315 ZINC96176865 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224368 CCOc1ncccc1C1C(C(=O)C2CCCC2)C(=O)C(=O)N1c1ccc(cc1)-c1ccsc1 InChI=1S/C27H26N2O4S/c1-2-33-26-21(8-5-14-28-26)23-22(24(30)18-6-3-4-7-18)25(31)27(32)29(23)20-11-9-17(10-12-20)19-13-15-34-16-19/h5,8-16,18,22-23H,2-4,6-7H2,1H3 DRYACHHLTIRGMR-UHFFFAOYSA-N 106005 US8575197, I-515 P2X purinoceptor 3 Homo sapiens 37 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106005 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106005&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808628 174008316 ZINC96176866 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224369 COCc1ccccc1C1C(C(=O)C2CCCC2)C(=O)C(=O)N1c1ccc(cc1)-c1ccsc1 InChI=1S/C28H27NO4S/c1-33-16-20-8-4-5-9-23(20)25-24(26(30)19-6-2-3-7-19)27(31)28(32)29(25)22-12-10-18(11-13-22)21-14-15-34-17-21/h4-5,8-15,17,19,24-25H,2-3,6-7,16H2,1H3 AQRAYRYLDPOBLZ-UHFFFAOYSA-N 106006 US8575197, I-516 P2X purinoceptor 3 Homo sapiens 33 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106006 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106006&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808629 174008317 ZINC96176867 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224370 CC(C)(C)C(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1ccon1)c1ccccc1OCC(N)=O InChI=1S/C26H25N3O6/c1-26(2,3)24(32)21-22(17-6-4-5-7-19(17)34-14-20(27)30)29(25(33)23(21)31)16-10-8-15(9-11-16)18-12-13-35-28-18/h4-13,21-22H,14H2,1-3H3,(H2,27,30) ANJIYUHEOKKGMR-UHFFFAOYSA-N 105634 US8575197, I-144 P2X purinoceptor 3 Homo sapiens 365 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105634 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105634&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808290 174007945 ZINC96176502 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224371 CS(=O)CCOc1ccccc1C1C(C(=O)C(C)(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccsc1 InChI=1S/C28H29NO5S2/c1-28(2,3)26(31)23-24(21-7-5-6-8-22(21)34-14-16-36(4)33)29(27(32)25(23)30)20-11-9-18(10-12-20)19-13-15-35-17-19/h5-13,15,17,23-24H,14,16H2,1-4H3 DIMBCIACPAMNME-UHFFFAOYSA-N 105635 US8575197, I-145 P2X purinoceptor 3 Homo sapiens 16 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105635 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105635&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808291 174007946 ZINC96176503 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224372 CNC(=O)COc1ccccc1C1C(C(=O)C(C)(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccon1 InChI=1S/C27H27N3O6/c1-27(2,3)25(33)22-23(18-7-5-6-8-20(18)35-15-21(31)28-4)30(26(34)24(22)32)17-11-9-16(10-12-17)19-13-14-36-29-19/h5-14,22-23H,15H2,1-4H3,(H,28,31) MMORPGLUHGAUGV-UHFFFAOYSA-N 105636 US8575197, I-146 P2X purinoceptor 3 Homo sapiens 727 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105636 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105636&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808292 174007947 ZINC96176504 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224373 CNC(=O)COc1ccccc1C1C(C(=O)C(C)(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccsc1 InChI=1S/C28H28N2O5S/c1-28(2,3)26(33)23-24(20-7-5-6-8-21(20)35-15-22(31)29-4)30(27(34)25(23)32)19-11-9-17(10-12-19)18-13-14-36-16-18/h5-14,16,23-24H,15H2,1-4H3,(H,29,31) NYUJUCLIXKCVEQ-UHFFFAOYSA-N 105637 US8575197, I-147 P2X purinoceptor 3 Homo sapiens 17 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105637 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105637&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808293 174007948 ZINC96176505 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224374 CN(C)C(=O)COc1ccccc1C1C(C(=O)C(C)(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccsc1 InChI=1S/C29H30N2O5S/c1-29(2,3)27(34)24-25(21-8-6-7-9-22(21)36-16-23(32)30(4)5)31(28(35)26(24)33)20-12-10-18(11-13-20)19-14-15-37-17-19/h6-15,17,24-25H,16H2,1-5H3 JIVITGOBGCDQLY-UHFFFAOYSA-N 105638 US8575197, I-148 P2X purinoceptor 3 Homo sapiens 73 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105638 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105638&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808294 174007949 ZINC96176506 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224375 COCCOc1ncccc1C1C(C(=O)C(C)(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1cccs1 InChI=1S/C27H28N2O5S/c1-27(2,3)24(31)21-22(19-7-5-13-28-25(19)34-15-14-33-4)29(26(32)23(21)30)18-11-9-17(10-12-18)20-8-6-16-35-20/h5-13,16,21-22H,14-15H2,1-4H3 DOEJAYHNWNEGSW-UHFFFAOYSA-N 105639 US8575197, I-149 P2X purinoceptor 3 Homo sapiens 15 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105639 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105639&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808295 174007950 ZINC96176507 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224376 COCCOc1ncccc1C1C(C(=O)C(C)(C)C)C(=O)C(=O)N1c1ccc(SC)cc1 InChI=1S/C24H28N2O5S/c1-24(2,3)21(28)18-19(17-7-6-12-25-22(17)31-14-13-30-4)26(23(29)20(18)27)15-8-10-16(32-5)11-9-15/h6-12,18-19H,13-14H2,1-5H3 CRHJQKCMAHFUPC-UHFFFAOYSA-N 105640 US8575197, I-150 P2X purinoceptor 3 Homo sapiens 415 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105640 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105640&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808296 174007951 ZINC96176508 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224377 CC(C)(C)C(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1ccsc1)c1ccccc1OCC(N)=O InChI=1S/C27H26N2O5S/c1-27(2,3)25(32)22-23(19-6-4-5-7-20(19)34-14-21(28)30)29(26(33)24(22)31)18-10-8-16(9-11-18)17-12-13-35-15-17/h4-13,15,22-23H,14H2,1-3H3,(H2,28,30) QNSMSNWWXJQFGK-UHFFFAOYSA-N 105641 US8575197, I-151 P2X purinoceptor 3 Homo sapiens 8 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105641 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105641&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808297 174007952 ZINC96176509 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224378 CS(=O)CCOc1ccccc1C1C(C(=O)C(C)(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccon1 InChI=1S/C27H28N2O6S/c1-27(2,3)25(31)22-23(19-7-5-6-8-21(19)34-15-16-36(4)33)29(26(32)24(22)30)18-11-9-17(10-12-18)20-13-14-35-28-20/h5-14,22-23H,15-16H2,1-4H3 MLSUHQFQPIWHPZ-UHFFFAOYSA-N 105642 US8575197, I-152 P2X purinoceptor 3 Homo sapiens 219 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105642 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105642&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808298 174007953 ZINC96176510 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224379 COCCOc1ccccc1C1C(C(=O)C(C)(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1cc[nH]c1 InChI=1S/C28H30N2O5/c1-28(2,3)26(32)23-24(21-7-5-6-8-22(21)35-16-15-34-4)30(27(33)25(23)31)20-11-9-18(10-12-20)19-13-14-29-17-19/h5-14,17,23-24,29H,15-16H2,1-4H3 VTCGDJQFSWDBMP-UHFFFAOYSA-N 105643 US8575197, I-153 P2X purinoceptor 3 Homo sapiens 216 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105643 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105643&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808299 174007954 ZINC96176511 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224380 CC(C)(C)C(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1cc[nH]c1)c1ccccc1OCCO InChI=1S/C27H28N2O5/c1-27(2,3)25(32)22-23(20-6-4-5-7-21(20)34-15-14-30)29(26(33)24(22)31)19-10-8-17(9-11-19)18-12-13-28-16-18/h4-13,16,22-23,28,30H,14-15H2,1-3H3 LTYKDRVVAAFCCQ-UHFFFAOYSA-N 105644 US8575197, I-154 P2X purinoceptor 3 Homo sapiens 192 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105644 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105644&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808300 174007955 ZINC96176512 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224381 CC(C)(C)C(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1ccoc1)c1ccccc1OCCO InChI=1S/C27H27NO6/c1-27(2,3)25(31)22-23(20-6-4-5-7-21(20)34-15-13-29)28(26(32)24(22)30)19-10-8-17(9-11-19)18-12-14-33-16-18/h4-12,14,16,22-23,29H,13,15H2,1-3H3 GDFIREXKOFQYQS-UHFFFAOYSA-N 105645 US8575197, I-155 P2X purinoceptor 3 Homo sapiens 35 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105645 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105645&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808301 174007956 ZINC96176513 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224382 COCCOc1ccccc1C1C(C(=O)C(C)(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccoc1 InChI=1S/C28H29NO6/c1-28(2,3)26(31)23-24(21-7-5-6-8-22(21)35-16-15-33-4)29(27(32)25(23)30)20-11-9-18(10-12-20)19-13-14-34-17-19/h5-14,17,23-24H,15-16H2,1-4H3 CMZVXOQOJGOXSB-UHFFFAOYSA-N 105646 US8575197, I-156 P2X purinoceptor 3 Homo sapiens 32 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105646 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105646&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808302 174007957 ZINC96176514 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224383 CC(C)C(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1ccsc1)c1ccccc1OCCN(C)C InChI=1S/C28H30N2O4S/c1-18(2)26(31)24-25(22-7-5-6-8-23(22)34-15-14-29(3)4)30(28(33)27(24)32)21-11-9-19(10-12-21)20-13-16-35-17-20/h5-13,16-18,24-25H,14-15H2,1-4H3 LEKHGLGAPNTVNF-UHFFFAOYSA-N 105647 US8575197, 261::US8575197, 262 P2X purinoceptor 3 Homo sapiens 25 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105647 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105647&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808303 174007958 ZINC96176515 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224384 CC(C)C(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1ccsc1)c1ccccc1OCCN(C)C InChI=1S/C28H30N2O4S/c1-18(2)26(31)24-25(22-7-5-6-8-23(22)34-15-14-29(3)4)30(28(33)27(24)32)21-11-9-19(10-12-21)20-13-16-35-17-20/h5-13,16-18,24-25H,14-15H2,1-4H3 LEKHGLGAPNTVNF-UHFFFAOYSA-N 105647 US8575197, 261::US8575197, 262 P2X purinoceptor 3 Homo sapiens 23 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105647 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105647&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808303 174007958 ZINC96176515 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224385 COc1ccccc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccsc1 InChI=1S/C25H23NO4S/c1-15(2)23(27)21-22(19-6-4-5-7-20(19)30-3)26(25(29)24(21)28)18-10-8-16(9-11-18)17-12-13-31-14-17/h4-15,21-22H,1-3H3 JPZAUDGHXGMCOI-UHFFFAOYSA-N 105649 US8575197, I-159 P2X purinoceptor 3 Homo sapiens 16 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105649 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105649&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808304 174007960 ZINC96176516 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224386 CC(C)C(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1ccsc1)c1ccccc1OCCO InChI=1S/C26H25NO5S/c1-16(2)24(29)22-23(20-5-3-4-6-21(20)32-13-12-28)27(26(31)25(22)30)19-9-7-17(8-10-19)18-11-14-33-15-18/h3-11,14-16,22-23,28H,12-13H2,1-2H3 LVIQIWFYDXOMFV-UHFFFAOYSA-N 105650 US8575197, I-160 P2X purinoceptor 3 Homo sapiens 13 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105650 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105650&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808305 174007961 ZINC96176517 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224387 COCCOc1ccccc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccsc1 InChI=1S/C27H27NO5S/c1-17(2)25(29)23-24(21-6-4-5-7-22(21)33-14-13-32-3)28(27(31)26(23)30)20-10-8-18(9-11-20)19-12-15-34-16-19/h4-12,15-17,23-24H,13-14H2,1-3H3 QLVFSDDQDUQTQP-UHFFFAOYSA-N 105651 US8575197, I-161 P2X purinoceptor 3 Homo sapiens 7 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105651 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105651&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808306 174007962 ZINC96176518 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224388 COCc1ncccc1C1C(C(=O)C(C)(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccsc1 InChI=1S/C26H26N2O4S/c1-26(2,3)24(30)21-22(19-6-5-12-27-20(19)14-32-4)28(25(31)23(21)29)18-9-7-16(8-10-18)17-11-13-33-15-17/h5-13,15,21-22H,14H2,1-4H3 ZHWSHUUPRSHJJO-UHFFFAOYSA-N 105652 US8575197, I-162 P2X purinoceptor 3 Homo sapiens 41 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105652 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105652&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808307 174007963 ZINC96176519 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224389 COCCOc1ncccc1C1C(C(=O)C(C)(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccoc1 InChI=1S/C27H28N2O6/c1-27(2,3)24(31)21-22(20-6-5-12-28-25(20)35-15-14-33-4)29(26(32)23(21)30)19-9-7-17(8-10-19)18-11-13-34-16-18/h5-13,16,21-22H,14-15H2,1-4H3 ASVYEFAALCBOET-UHFFFAOYSA-N 105654 US8575197, I-164 P2X purinoceptor 3 Homo sapiens 74 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105654 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105654&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808308 174007965 ZINC96176521 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224390 CC(C)(C)C(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1ccoc1)c1cccnc1OCCO InChI=1S/C26H26N2O6/c1-26(2,3)23(31)20-21(19-5-4-11-27-24(19)34-14-12-29)28(25(32)22(20)30)18-8-6-16(7-9-18)17-10-13-33-15-17/h4-11,13,15,20-21,29H,12,14H2,1-3H3 PTIQLLBJGHECCZ-UHFFFAOYSA-N 105655 US8575197, I-165 P2X purinoceptor 3 Homo sapiens 95 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105655 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105655&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808309 174007966 ZINC96176522 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224391 CC(C)(C)C(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1ccsc1)c1cccnc1OCCO InChI=1S/C26H26N2O5S/c1-26(2,3)23(31)20-21(19-5-4-11-27-24(19)33-13-12-29)28(25(32)22(20)30)18-8-6-16(7-9-18)17-10-14-34-15-17/h4-11,14-15,20-21,29H,12-13H2,1-3H3 PLGXUQQCRKXKLB-UHFFFAOYSA-N 105656 US8575197, I-166 P2X purinoceptor 3 Homo sapiens 19 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105656 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105656&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808310 174007967 ZINC96176523 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224392 CC(C)C(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1ccsc1)c1ccccc1OCCS(C)=O InChI=1S/C27H27NO5S2/c1-17(2)25(29)23-24(21-6-4-5-7-22(21)33-13-15-35(3)32)28(27(31)26(23)30)20-10-8-18(9-11-20)19-12-14-34-16-19/h4-12,14,16-17,23-24H,13,15H2,1-3H3 GCWKKMVVNFRHLI-UHFFFAOYSA-N 105657 US8575197, I-167 P2X purinoceptor 3 Homo sapiens 13 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105657 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105657&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808311 174007968 ZINC96176524 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224393 COCCOCc1ncccc1C1C(C(=O)C(C)(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccsc1 InChI=1S/C28H30N2O5S/c1-28(2,3)26(32)23-24(21-6-5-12-29-22(21)16-35-14-13-34-4)30(27(33)25(23)31)20-9-7-18(8-10-20)19-11-15-36-17-19/h5-12,15,17,23-24H,13-14,16H2,1-4H3 QSRLPTVHMDFWQP-UHFFFAOYSA-N 105658 US8575197, I-168 P2X purinoceptor 3 Homo sapiens 120 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105658 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105658&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808312 174007969 ZINC96176525 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224394 COCCOc1ncccc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccsc1 InChI=1S/C26H26N2O5S/c1-16(2)23(29)21-22(20-5-4-11-27-25(20)33-13-12-32-3)28(26(31)24(21)30)19-8-6-17(7-9-19)18-10-14-34-15-18/h4-11,14-16,21-22H,12-13H2,1-3H3 IWWLAXGNKQEFNJ-UHFFFAOYSA-N 105659 US8575197, I-169 P2X purinoceptor 3 Homo sapiens 19 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105659 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105659&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808313 174007970 ZINC96176526 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224395 CSc1ccc(cc1)N1C(C(C(=O)C(C)(C)C)C(=O)C1=O)c1cccnc1OCCO InChI=1S/C23H26N2O5S/c1-23(2,3)20(28)17-18(16-6-5-11-24-21(16)30-13-12-26)25(22(29)19(17)27)14-7-9-15(31-4)10-8-14/h5-11,17-18,26H,12-13H2,1-4H3 UONCJCFRSNZYED-UHFFFAOYSA-N 105661 US8575197, I-171 P2X purinoceptor 3 Homo sapiens 610 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105661 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105661&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808314 174007972 ZINC96176528 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224396 CC(C)(C)C(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1cccs1)c1cccnc1OCCO InChI=1S/C26H26N2O5S/c1-26(2,3)23(31)20-21(18-6-4-12-27-24(18)33-14-13-29)28(25(32)22(20)30)17-10-8-16(9-11-17)19-7-5-15-34-19/h4-12,15,20-21,29H,13-14H2,1-3H3 QRUOOAMLMIBOOS-UHFFFAOYSA-N 105662 US8575197, I-172 P2X purinoceptor 3 Homo sapiens 24 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105662 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105662&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808315 174007973 ZINC96176529 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224397 CC(C)(C)C(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1ccco1)c1cccnc1OCCO InChI=1S/C26H26N2O6/c1-26(2,3)23(31)20-21(18-6-4-12-27-24(18)34-15-13-29)28(25(32)22(20)30)17-10-8-16(9-11-17)19-7-5-14-33-19/h4-12,14,20-21,29H,13,15H2,1-3H3 FOHBSWBGONDZEW-UHFFFAOYSA-N 105663 US8575197, I-173 P2X purinoceptor 3 Homo sapiens 137 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105663 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105663&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808316 174007974 ZINC96176530 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224398 COCCOc1ncccc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1noc(C)n1 InChI=1S/C25H26N4O6/c1-14(2)21(30)19-20(18-6-5-11-26-24(18)34-13-12-33-4)29(25(32)22(19)31)17-9-7-16(8-10-17)23-27-15(3)35-28-23/h5-11,14,19-20H,12-13H2,1-4H3 OMKACVRXRXJLOW-UHFFFAOYSA-N 105664 US8575197, I-174 P2X purinoceptor 3 Homo sapiens 572 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105664 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105664&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808317 174007975 ZINC96176531 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224399 CC(C)C(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1ccsc1)c1cccnc1OCCO InChI=1S/C25H24N2O5S/c1-15(2)22(29)20-21(19-4-3-10-26-24(19)32-12-11-28)27(25(31)23(20)30)18-7-5-16(6-8-18)17-9-13-33-14-17/h3-10,13-15,20-21,28H,11-12H2,1-2H3 ZFKJGMNNHWCJSO-UHFFFAOYSA-N 105666 US8575197, I-176 P2X purinoceptor 3 Homo sapiens 46 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105666 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105666&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808318 174007977 ZINC96176533 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224400 CC(C)C(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1noc(C)n1)c1cccnc1OCCO InChI=1S/C24H24N4O6/c1-13(2)20(30)18-19(17-5-4-10-25-23(17)33-12-11-29)28(24(32)21(18)31)16-8-6-15(7-9-16)22-26-14(3)34-27-22/h4-10,13,18-19,29H,11-12H2,1-3H3 GLELIAKIQMPREE-UHFFFAOYSA-N 105668 US8575197, I-178 P2X purinoceptor 3 Homo sapiens 374 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105668 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105668&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808319 174007979 ZINC96176535 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224401 CC(C)C(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1ccon1)c1cccnc1OCCO InChI=1S/C24H23N3O6/c1-14(2)21(29)19-20(17-4-3-10-25-23(17)32-13-11-28)27(24(31)22(19)30)16-7-5-15(6-8-16)18-9-12-33-26-18/h3-10,12,14,19-20,28H,11,13H2,1-2H3 JVQJYPZKQIGGJL-UHFFFAOYSA-N 105669 US8575197, I-179 P2X purinoceptor 3 Homo sapiens 659 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105669 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105669&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808320 174007980 ZINC96176536 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224402 CC(C)(C)C(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1ccsc1)c1ccccc1OCC#N InChI=1S/C27H24N2O4S/c1-27(2,3)25(31)22-23(20-6-4-5-7-21(20)33-14-13-28)29(26(32)24(22)30)19-10-8-17(9-11-19)18-12-15-34-16-18/h4-12,15-16,22-23H,14H2,1-3H3 MMXNRVMVJKJILL-UHFFFAOYSA-N 105670 US8575197, I-180 P2X purinoceptor 3 Homo sapiens 5 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105670 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105670&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808321 174007981 ZINC96176537 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224403 COC(=O)COCc1ncccc1C1C(C(=O)C(C)(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccsc1 InChI=1S/C28H28N2O6S/c1-28(2,3)26(33)23-24(20-6-5-12-29-21(20)14-36-15-22(31)35-4)30(27(34)25(23)32)19-9-7-17(8-10-19)18-11-13-37-16-18/h5-13,16,23-24H,14-15H2,1-4H3 KKEPIHUSMNAPLF-UHFFFAOYSA-N 105671 US8575197, I-181 P2X purinoceptor 3 Homo sapiens 114 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105671 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105671&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808322 174007982 ZINC96176538 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224404 CC(C)C(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1ccsc1)c1ccccc1OCC#N InChI=1S/C26H22N2O4S/c1-16(2)24(29)22-23(20-5-3-4-6-21(20)32-13-12-27)28(26(31)25(22)30)19-9-7-17(8-10-19)18-11-14-33-15-18/h3-11,14-16,22-23H,13H2,1-2H3 HOTAIHKPYKFYBB-UHFFFAOYSA-N 105673 US8575197, I-183 P2X purinoceptor 3 Homo sapiens 4 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105673&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808323 174007984 ZINC96176540 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224405 CC(C)(C)C(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1ccsc1)c1ccccc1C(O)=O InChI=1S/C26H23NO5S/c1-26(2,3)23(29)20-21(18-6-4-5-7-19(18)25(31)32)27(24(30)22(20)28)17-10-8-15(9-11-17)16-12-13-33-14-16/h4-14,20-21H,1-3H3,(H,31,32) UNIWCWKTESBTIJ-UHFFFAOYSA-N 105674 US8575197, I-184 P2X purinoceptor 3 Homo sapiens 163 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105674 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105674&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808324 174007985 ZINC96176541 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224406 CC(C)C(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1ccsc1)c1ccccc1OCC(O)=O InChI=1S/C26H23NO6S/c1-15(2)24(30)22-23(19-5-3-4-6-20(19)33-13-21(28)29)27(26(32)25(22)31)18-9-7-16(8-10-18)17-11-12-34-14-17/h3-12,14-15,22-23H,13H2,1-2H3,(H,28,29) WJCPRPGVJVFDMX-UHFFFAOYSA-N 105675 US8575197, I-185 P2X purinoceptor 3 Homo sapiens 111 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105675 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105675&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808325 174007986 ZINC96176542 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224407 COCc1ccccc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccsc1 InChI=1S/C26H25NO4S/c1-16(2)24(28)22-23(21-7-5-4-6-18(21)14-31-3)27(26(30)25(22)29)20-10-8-17(9-11-20)19-12-13-32-15-19/h4-13,15-16,22-23H,14H2,1-3H3 WZEWWSYBFASMGA-UHFFFAOYSA-N 105676 US8575197, I-186 P2X purinoceptor 3 Homo sapiens 13 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105676 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105676&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808326 174007987 ZINC96176543 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224408 COc1ncccc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccsc1 InChI=1S/C24H22N2O4S/c1-14(2)21(27)19-20(18-5-4-11-25-23(18)30-3)26(24(29)22(19)28)17-8-6-15(7-9-17)16-10-12-31-13-16/h4-14,19-20H,1-3H3 JZIWNRVCAKYHMR-UHFFFAOYSA-N 105677 US8575197, I-187 P2X purinoceptor 3 Homo sapiens 86 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105677 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105677&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808327 174007988 ZINC96176544 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224409 CNC(=O)COc1ccccc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccsc1 InChI=1S/C27H26N2O5S/c1-16(2)25(31)23-24(20-6-4-5-7-21(20)34-14-22(30)28-3)29(27(33)26(23)32)19-10-8-17(9-11-19)18-12-13-35-15-18/h4-13,15-16,23-24H,14H2,1-3H3,(H,28,30) ADEOGMSEYONGTO-UHFFFAOYSA-N 105678 US8575197, I-188 P2X purinoceptor 3 Homo sapiens 22 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105678 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105678&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808328 174007989 ZINC96176545 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224410 CC(C)C(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1ccsc1)c1ccccc1OCC(N)=O InChI=1S/C26H24N2O5S/c1-15(2)24(30)22-23(19-5-3-4-6-20(19)33-13-21(27)29)28(26(32)25(22)31)18-9-7-16(8-10-18)17-11-12-34-14-17/h3-12,14-15,22-23H,13H2,1-2H3,(H2,27,29) RHZCVBGZRQHMMD-UHFFFAOYSA-N 105679 US8575197, I-189 P2X purinoceptor 3 Homo sapiens 14 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105679 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105679&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808329 174007990 ZINC96176546 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224411 CC(C)C(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1ccoc1)c1ccccc1OCCO InChI=1S/C26H25NO6/c1-16(2)24(29)22-23(20-5-3-4-6-21(20)33-14-12-28)27(26(31)25(22)30)19-9-7-17(8-10-19)18-11-13-32-15-18/h3-11,13,15-16,22-23,28H,12,14H2,1-2H3 UGPPTQGKXRFYKI-UHFFFAOYSA-N 105680 US8575197, I-190 P2X purinoceptor 3 Homo sapiens 40 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105680 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105680&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808330 174007991 ZINC96176547 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224412 CC(C)C(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1ccon1)c1ccccc1OCCO InChI=1S/C25H24N2O6/c1-15(2)23(29)21-22(18-5-3-4-6-20(18)32-14-12-28)27(25(31)24(21)30)17-9-7-16(8-10-17)19-11-13-33-26-19/h3-11,13,15,21-22,28H,12,14H2,1-2H3 ILSPJTCPWPUOPY-UHFFFAOYSA-N 105681 US8575197, I-191 P2X purinoceptor 3 Homo sapiens 279 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105681 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105681&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808331 174007992 ZINC96176548 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224413 COc1ccccc1C1C(C(=O)C(C)(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccsc1Cl InChI=1S/C26H24ClNO4S/c1-26(2,3)23(30)20-21(18-7-5-6-8-19(18)32-4)28(25(31)22(20)29)16-11-9-15(10-12-16)17-13-14-33-24(17)27/h5-14,20-21H,1-4H3 BUQWYFSGTMXJCV-UHFFFAOYSA-N 105682 US8575197, I-192 P2X purinoceptor 3 Homo sapiens 612 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105682 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105682&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808332 174007993 ZINC96176549 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224414 COc1ccccc1C1C(C(=O)C(C)(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1cscc1C InChI=1S/C27H27NO4S/c1-16-14-33-15-20(16)17-10-12-18(13-11-17)28-23(19-8-6-7-9-21(19)32-5)22(24(29)26(28)31)25(30)27(2,3)4/h6-15,22-23H,1-5H3 IVUTVUHRHSUUGL-UHFFFAOYSA-N 105683 US8575197, 297 P2X purinoceptor 3 Homo sapiens 994 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105683 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105683&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808333 174007994 ZINC96176550 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224415 COCc1ncccc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccsc1 InChI=1S/C25H24N2O4S/c1-15(2)23(28)21-22(19-5-4-11-26-20(19)13-31-3)27(25(30)24(21)29)18-8-6-16(7-9-18)17-10-12-32-14-17/h4-12,14-15,21-22H,13H2,1-3H3 XKJJXLWTHLAQBT-UHFFFAOYSA-N 105684 US8575197, I-194 P2X purinoceptor 3 Homo sapiens 63 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105684 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105684&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808334 174007995 ZINC96176551 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224416 CC(C)C(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1ccsc1)c1cccnc1OCC(O)=O InChI=1S/C25H22N2O6S/c1-14(2)22(30)20-21(18-4-3-10-26-24(18)33-12-19(28)29)27(25(32)23(20)31)17-7-5-15(6-8-17)16-9-11-34-13-16/h3-11,13-14,20-21H,12H2,1-2H3,(H,28,29) HBEIHLAWJMQKES-UHFFFAOYSA-N 105685 US8575197, I-195 P2X purinoceptor 3 Homo sapiens 235 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105685 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105685&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808335 174007996 ZINC96176552 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224417 COc1ccccc1C1C(C(=O)C(C)(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1csc(C)c1 InChI=1S/C27H27NO4S/c1-16-14-18(15-33-16)17-10-12-19(13-11-17)28-23(20-8-6-7-9-21(20)32-5)22(24(29)26(28)31)25(30)27(2,3)4/h6-15,22-23H,1-5H3 YOXLMZIPXKLUEF-UHFFFAOYSA-N 105687 US8575197, I-197 P2X purinoceptor 3 Homo sapiens 36 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105687 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105687&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808336 174007998 ZINC96176554 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224418 COc1ccccc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccoc1 InChI=1S/C25H23NO5/c1-15(2)23(27)21-22(19-6-4-5-7-20(19)30-3)26(25(29)24(21)28)18-10-8-16(9-11-18)17-12-13-31-14-17/h4-15,21-22H,1-3H3 JCYYMPXQRKTVFQ-UHFFFAOYSA-N 105688 US8575197, I-198 P2X purinoceptor 3 Homo sapiens 64 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105688 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105688&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808337 174007999 ZINC96176555 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224419 COc1ncccc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccc(C)s1 InChI=1S/C25H24N2O4S/c1-14(2)22(28)20-21(18-6-5-13-26-24(18)31-4)27(25(30)23(20)29)17-10-8-16(9-11-17)19-12-7-15(3)32-19/h5-14,20-21H,1-4H3 NTSOSZQJPXPQHI-UHFFFAOYSA-N 105822 US8575197, I-332 P2X purinoceptor 3 Homo sapiens 281 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105822 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105822&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808459 174008133 ZINC96176684 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224420 CC(C)C(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1ccc(C)s1)c1ccccc1OC(F)F InChI=1S/C26H23F2NO4S/c1-14(2)23(30)21-22(18-6-4-5-7-19(18)33-26(27)28)29(25(32)24(21)31)17-11-9-16(10-12-17)20-13-8-15(3)34-20/h4-14,21-22,26H,1-3H3 IJNVFEOYCKBHGT-UHFFFAOYSA-N 105823 US8575197, I-333 P2X purinoceptor 3 Homo sapiens 58 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105823 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105823&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808460 174008134 ZINC96176685 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224421 CC(C)C(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1ccc(C)s1)c1ccccc1OC(F)(F)F InChI=1S/C26H22F3NO4S/c1-14(2)23(31)21-22(18-6-4-5-7-19(18)34-26(27,28)29)30(25(33)24(21)32)17-11-9-16(10-12-17)20-13-8-15(3)35-20/h4-14,21-22H,1-3H3 DZRXXQCKCNGFIH-UHFFFAOYSA-N 105824 US8575197, I-334 P2X purinoceptor 3 Homo sapiens 78 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105824 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105824&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808461 174008135 ZINC96176686 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224422 COc1ncccc1C1C(C(=O)CC(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccc(C)s1 InChI=1S/C26H26N2O4S/c1-15(2)14-20(29)22-23(19-6-5-13-27-25(19)32-4)28(26(31)24(22)30)18-10-8-17(9-11-18)21-12-7-16(3)33-21/h5-13,15,22-23H,14H2,1-4H3 VGIFRMRRHOVYJQ-UHFFFAOYSA-N 105826 US8575197, I-336 P2X purinoceptor 3 Homo sapiens 351 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105826 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105826&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808462 174008137 ZINC96176688 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224423 CC(C)CC(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1ccc(C)s1)c1ccccc1OC(F)F InChI=1S/C27H25F2NO4S/c1-15(2)14-20(31)23-24(19-6-4-5-7-21(19)34-27(28)29)30(26(33)25(23)32)18-11-9-17(10-12-18)22-13-8-16(3)35-22/h4-13,15,23-24,27H,14H2,1-3H3 HDBAFTRXEFAHQL-UHFFFAOYSA-N 105827 US8575197, I-337 P2X purinoceptor 3 Homo sapiens 103 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105827 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105827&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808463 174008138 ZINC96176689 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224424 CC(C)CC(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1ccc(C)s1)c1ccccc1OC(F)(F)F InChI=1S/C27H24F3NO4S/c1-15(2)14-20(32)23-24(19-6-4-5-7-21(19)35-27(28,29)30)31(26(34)25(23)33)18-11-9-17(10-12-18)22-13-8-16(3)36-22/h4-13,15,23-24H,14H2,1-3H3 HDZGIVMLLWKRII-UHFFFAOYSA-N 105828 US8575197, I-338 P2X purinoceptor 3 Homo sapiens 147 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105828 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105828&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808464 174008139 ZINC96176690 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224425 COc1ccccc1C1C(C(=O)CC(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1cc(C)no1 InChI=1S/C26H26N2O5/c1-15(2)13-20(29)23-24(19-7-5-6-8-21(19)32-4)28(26(31)25(23)30)18-11-9-17(10-12-18)22-14-16(3)27-33-22/h5-12,14-15,23-24H,13H2,1-4H3 YQAFMSIZNYISEV-UHFFFAOYSA-N 105829 US8575197, I-339 P2X purinoceptor 3 Homo sapiens 892 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105829 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105829&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808465 174008140 ZINC96176691 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224426 COc1ncccc1C1C(C(=O)CC(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccoc1 InChI=1S/C25H24N2O5/c1-15(2)13-20(28)21-22(19-5-4-11-26-24(19)31-3)27(25(30)23(21)29)18-8-6-16(7-9-18)17-10-12-32-14-17/h4-12,14-15,21-22H,13H2,1-3H3 QCWKXUNELBCBBI-UHFFFAOYSA-N 105830 US8575197, I-340 P2X purinoceptor 3 Homo sapiens 336 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105830 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105830&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808466 174008141 ZINC96176692 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224427 CC(C)CC(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1cc(C)no1)c1ccccc1OC(F)F InChI=1S/C26H24F2N2O5/c1-14(2)12-19(31)22-23(18-6-4-5-7-20(18)34-26(27)28)30(25(33)24(22)32)17-10-8-16(9-11-17)21-13-15(3)29-35-21/h4-11,13-14,22-23,26H,12H2,1-3H3 JIGWPBMBWOWQER-UHFFFAOYSA-N 105831 US8575197, I-341 P2X purinoceptor 3 Homo sapiens 508 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105831 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105831&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808467 174008142 ZINC96176693 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224428 CC(C)CC(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1ccoc1)c1ccccc1OC(F)F InChI=1S/C26H23F2NO5/c1-15(2)13-20(30)22-23(19-5-3-4-6-21(19)34-26(27)28)29(25(32)24(22)31)18-9-7-16(8-10-18)17-11-12-33-14-17/h3-12,14-15,22-23,26H,13H2,1-2H3 OIUWXXOCDKIPFB-UHFFFAOYSA-N 105832 US8575197, I-342 P2X purinoceptor 3 Homo sapiens 67 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105832 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105832&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808468 174008143 ZINC96176694 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224429 CC(C)CC(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1ccoc1)c1ccccc1OC(F)(F)F InChI=1S/C26H22F3NO5/c1-15(2)13-20(31)22-23(19-5-3-4-6-21(19)35-26(27,28)29)30(25(33)24(22)32)18-9-7-16(8-10-18)17-11-12-34-14-17/h3-12,14-15,22-23H,13H2,1-2H3 STSKMHXQSZSFGY-UHFFFAOYSA-N 105833 US8575197, I-343 P2X purinoceptor 3 Homo sapiens 78 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105833 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105833&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808469 174008144 ZINC96176695 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224430 CC(C)CC(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1cc(C)no1)c1ccccc1OC(F)(F)F InChI=1S/C26H23F3N2O5/c1-14(2)12-19(32)22-23(18-6-4-5-7-20(18)35-26(27,28)29)31(25(34)24(22)33)17-10-8-16(9-11-17)21-13-15(3)30-36-21/h4-11,13-14,22-23H,12H2,1-3H3 VMCGWPHGXNFOMY-UHFFFAOYSA-N 105834 US8575197, I-344 P2X purinoceptor 3 Homo sapiens 594 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105834 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105834&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808470 174008145 ZINC96176696 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224431 CC(C)CC(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1cc(C)no1)c1ccccc1OCCO InChI=1S/C27H28N2O6/c1-16(2)14-21(31)24-25(20-6-4-5-7-22(20)34-13-12-30)29(27(33)26(24)32)19-10-8-18(9-11-19)23-15-17(3)28-35-23/h4-11,15-16,24-25,30H,12-14H2,1-3H3 CPDCUEDAFHIEAT-UHFFFAOYSA-N 105835 US8575197, I-345 P2X purinoceptor 3 Homo sapiens 999 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105835 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105835&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808471 174008146 ZINC96176697 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224432 COCCOc1ccccc1C1C(C(=O)CC(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1cc(C)no1 InChI=1S/C28H30N2O6/c1-17(2)15-22(31)25-26(21-7-5-6-8-23(21)35-14-13-34-4)30(28(33)27(25)32)20-11-9-19(10-12-20)24-16-18(3)29-36-24/h5-12,16-17,25-26H,13-15H2,1-4H3 NIDGMTMZMPZFNW-UHFFFAOYSA-N 105836 US8575197, I-346 P2X purinoceptor 3 Homo sapiens 677 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105836 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105836&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808472 174008147 ZINC96176698 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224433 CCOc1ccccc1C1C(C(=O)CC(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccoc1 InChI=1S/C27H27NO5/c1-4-33-23-8-6-5-7-21(23)25-24(22(29)15-17(2)3)26(30)27(31)28(25)20-11-9-18(10-12-20)19-13-14-32-16-19/h5-14,16-17,24-25H,4,15H2,1-3H3 HOUBYRVMHAMDRQ-UHFFFAOYSA-N 105837 US8575197, I-347 P2X purinoceptor 3 Homo sapiens 47 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105837 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105837&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808473 174008148 ZINC96176699 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224434 COCCOc1ccccc1C1C(C(=O)CC(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccoc1 InChI=1S/C28H29NO6/c1-18(2)16-23(30)25-26(22-6-4-5-7-24(22)35-15-14-33-3)29(28(32)27(25)31)21-10-8-19(9-11-21)20-12-13-34-17-20/h4-13,17-18,25-26H,14-16H2,1-3H3 IGGOEYVXTBAWRY-UHFFFAOYSA-N 105838 US8575197, I-348 P2X purinoceptor 3 Homo sapiens 55 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105838 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105838&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808474 174008149 ZINC96176700 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224435 COCOc1ccccc1C1C(C(=O)CC(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccoc1 InChI=1S/C27H27NO6/c1-17(2)14-22(29)24-25(21-6-4-5-7-23(21)34-16-32-3)28(27(31)26(24)30)20-10-8-18(9-11-20)19-12-13-33-15-19/h4-13,15,17,24-25H,14,16H2,1-3H3 WPIBEZVPOZWYSQ-UHFFFAOYSA-N 105839 US8575197, I-349 P2X purinoceptor 3 Homo sapiens 37 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105839 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105839&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808475 174008150 ZINC96176701 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224436 CC(C)CC(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1ccoc1)c1ccccc1OCCO InChI=1S/C27H27NO6/c1-17(2)15-22(30)24-25(21-5-3-4-6-23(21)34-14-12-29)28(27(32)26(24)31)20-9-7-18(8-10-20)19-11-13-33-16-19/h3-11,13,16-17,24-25,29H,12,14-15H2,1-2H3 YSFKDHXDCZEENM-UHFFFAOYSA-N 105840 US8575197, I-350 P2X purinoceptor 3 Homo sapiens 66 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105840 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105840&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808476 174008151 ZINC96176702 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224437 COc1ccccc1C1C(C(=O)CC(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccoc1 InChI=1S/C26H25NO5/c1-16(2)14-21(28)23-24(20-6-4-5-7-22(20)31-3)27(26(30)25(23)29)19-10-8-17(9-11-19)18-12-13-32-15-18/h4-13,15-16,23-24H,14H2,1-3H3 PAHNLOXMQJPRCI-UHFFFAOYSA-N 105841 US8575197, I-351 P2X purinoceptor 3 Homo sapiens 101 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105841 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105841&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808477 174008152 ZINC96176703 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224438 COCc1ccccc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc2n(C)c(C)cc2c1 InChI=1S/C26H28N2O4/c1-15(2)24(29)22-23(20-9-7-6-8-17(20)14-32-5)28(26(31)25(22)30)19-10-11-21-18(13-19)12-16(3)27(21)4/h6-13,15,22-23H,14H2,1-5H3 RVTIOLYHVOWRLI-UHFFFAOYSA-N 105843 US8575197, I-353 P2X purinoceptor 3 Homo sapiens 210 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105843 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105843&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808478 174008154 ZINC96176705 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224439 COCc1ccccc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccco1 InChI=1S/C26H25NO5/c1-16(2)24(28)22-23(20-8-5-4-7-18(20)15-31-3)27(26(30)25(22)29)19-12-10-17(11-13-19)21-9-6-14-32-21/h4-14,16,22-23H,15H2,1-3H3 NMGZEVLLASUZIY-UHFFFAOYSA-N 105844 US8575197, I-354 P2X purinoceptor 3 Homo sapiens 57 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105844 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105844&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808479 174008155 ZINC96176706 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224440 COCc1ccccc1C1C(C(=O)CC(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccco1 InChI=1S/C27H27NO5/c1-17(2)15-22(29)24-25(21-8-5-4-7-19(21)16-32-3)28(27(31)26(24)30)20-12-10-18(11-13-20)23-9-6-14-33-23/h4-14,17,24-25H,15-16H2,1-3H3 CEUQNZWTQYQJKT-UHFFFAOYSA-N 105845 US8575197, I-355 P2X purinoceptor 3 Homo sapiens 44 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105845 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105845&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808480 174008156 ZINC96176707 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224441 COCc1ccccc1[C@@H]1C(C(=O)CC(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccsc1 InChI=1S/C27H27NO4S/c1-17(2)14-23(29)24-25(22-7-5-4-6-19(22)15-32-3)28(27(31)26(24)30)21-10-8-18(9-11-21)20-12-13-33-16-20/h4-13,16-17,24-25H,14-15H2,1-3H3/t24?,25-/m1/s1 ACJAHHCOANCIQB-WUBHUQEYSA-N 105846 US8575197, I-356 P2X purinoceptor 3 Homo sapiens 7 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105846 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105846&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808481 174008157 ZINC96176708 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224442 COCCOc1ncccc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccc(C)o1 InChI=1S/C27H28N2O6/c1-16(2)24(30)22-23(20-6-5-13-28-26(20)34-15-14-33-4)29(27(32)25(22)31)19-10-8-18(9-11-19)21-12-7-17(3)35-21/h5-13,16,22-23H,14-15H2,1-4H3 RHNRIPQNWYXXNY-UHFFFAOYSA-N 105847 US8575197, I-357 P2X purinoceptor 3 Homo sapiens 20 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105847 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105847&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808482 174008158 ZINC96176709 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224443 CC(C)C(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1ccc(C)o1)c1ccccc1OC(F)F InChI=1S/C26H23F2NO5/c1-14(2)23(30)21-22(18-6-4-5-7-20(18)34-26(27)28)29(25(32)24(21)31)17-11-9-16(10-12-17)19-13-8-15(3)33-19/h4-14,21-22,26H,1-3H3 JSSVAFDYCITTLC-UHFFFAOYSA-N 105848 US8575197, I-358 P2X purinoceptor 3 Homo sapiens 25 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105848 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105848&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808483 174008159 ZINC96176710 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224444 CC(C)C(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1ccc(C)o1)c1ccccc1OC(F)(F)F InChI=1S/C26H22F3NO5/c1-14(2)23(31)21-22(18-6-4-5-7-20(18)35-26(27,28)29)30(25(33)24(21)32)17-11-9-16(10-12-17)19-13-8-15(3)34-19/h4-14,21-22H,1-3H3 DJBCEZOWCZXMMC-UHFFFAOYSA-N 105849 US8575197, I-359 P2X purinoceptor 3 Homo sapiens 24 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105849 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105849&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808484 174008160 ZINC96176711 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224445 COCCOc1ncccc1C1C(C(=O)CC(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccc(C)o1 InChI=1S/C28H30N2O6/c1-17(2)16-22(31)24-25(21-6-5-13-29-27(21)35-15-14-34-4)30(28(33)26(24)32)20-10-8-19(9-11-20)23-12-7-18(3)36-23/h5-13,17,24-25H,14-16H2,1-4H3 PNQPHJREMQOXLL-UHFFFAOYSA-N 105850 US8575197, I-360 P2X purinoceptor 3 Homo sapiens 21 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105850 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105850&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808485 174008161 ZINC96176712 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224446 CC(C)CC(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1ccc(C)o1)c1ccccc1OC(F)F InChI=1S/C27H25F2NO5/c1-15(2)14-20(31)23-24(19-6-4-5-7-22(19)35-27(28)29)30(26(33)25(23)32)18-11-9-17(10-12-18)21-13-8-16(3)34-21/h4-13,15,23-24,27H,14H2,1-3H3 WYIMYGDMIGRXKW-UHFFFAOYSA-N 105851 US8575197, I-361 P2X purinoceptor 3 Homo sapiens 48 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105851 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105851&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808486 174008162 ZINC96176713 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224447 CC(C)CC(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1ccc(C)o1)c1ccccc1OC(F)(F)F InChI=1S/C27H24F3NO5/c1-15(2)14-20(32)23-24(19-6-4-5-7-22(19)36-27(28,29)30)31(26(34)25(23)33)18-11-9-17(10-12-18)21-13-8-16(3)35-21/h4-13,15,23-24H,14H2,1-3H3 XCWOMIIGQAFJDG-UHFFFAOYSA-N 105852 US8575197, I-362 P2X purinoceptor 3 Homo sapiens 40 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105852 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105852&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808487 174008163 ZINC96176714 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224448 COCCOc1cc(F)ccc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccsc1 InChI=1S/C27H26FNO5S/c1-16(2)25(30)23-24(21-9-6-19(28)14-22(21)34-12-11-33-3)29(27(32)26(23)31)20-7-4-17(5-8-20)18-10-13-35-15-18/h4-10,13-16,23-24H,11-12H2,1-3H3 DBNGAYHDISVOOK-UHFFFAOYSA-N 105853 US8575197, I-363 P2X purinoceptor 3 Homo sapiens 7 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105853 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105853&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808488 174008164 ZINC96176715 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224449 COCCOc1cc(F)ccc1C1C(C(=O)CC(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccsc1 InChI=1S/C28H28FNO5S/c1-17(2)14-23(31)25-26(22-9-6-20(29)15-24(22)35-12-11-34-3)30(28(33)27(25)32)21-7-4-18(5-8-21)19-10-13-36-16-19/h4-10,13,15-17,25-26H,11-12,14H2,1-3H3 MFHBGVIYHUPDMO-UHFFFAOYSA-N 105854 US8575197, I-364 P2X purinoceptor 3 Homo sapiens 9 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105854 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105854&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808489 174008165 ZINC96176716 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224450 COCCOc1cc(F)ccc1C1C(C(=O)CC(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1noc(C)n1 InChI=1S/C27H28FN3O6/c1-15(2)13-21(32)23-24(20-10-7-18(28)14-22(20)36-12-11-35-4)31(27(34)25(23)33)19-8-5-17(6-9-19)26-29-16(3)37-30-26/h5-10,14-15,23-24H,11-13H2,1-4H3 ZTWFKPMOCOUFNQ-UHFFFAOYSA-N 105855 US8575197, I-365 P2X purinoceptor 3 Homo sapiens 82 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105855 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105855&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808490 174008166 ZINC96176717 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224451 CC(C)CC(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1ccsc1)c1ccccc1OCCCO InChI=1S/C28H29NO5S/c1-18(2)16-23(31)25-26(22-6-3-4-7-24(22)34-14-5-13-30)29(28(33)27(25)32)21-10-8-19(9-11-21)20-12-15-35-17-20/h3-4,6-12,15,17-18,25-26,30H,5,13-14,16H2,1-2H3 HBEHNHJYKUJRST-UHFFFAOYSA-N 105856 US8575197, I-366 P2X purinoceptor 3 Homo sapiens 13 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105856 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105856&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808491 174008167 ZINC96176718 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224452 COCCOc1cc(F)ccc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccoc1 InChI=1S/C27H26FNO6/c1-16(2)25(30)23-24(21-9-6-19(28)14-22(21)35-13-12-33-3)29(27(32)26(23)31)20-7-4-17(5-8-20)18-10-11-34-15-18/h4-11,14-16,23-24H,12-13H2,1-3H3 LZQRURULKXKLSC-UHFFFAOYSA-N 105857 US8575197, I-367 P2X purinoceptor 3 Homo sapiens 19 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105857 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105857&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808492 174008168 ZINC96176719 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224453 COCCOc1cc(F)ccc1C1C(C(=O)CC(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccoc1 InChI=1S/C28H28FNO6/c1-17(2)14-23(31)25-26(22-9-6-20(29)15-24(22)36-13-12-34-3)30(28(33)27(25)32)21-7-4-18(5-8-21)19-10-11-35-16-19/h4-11,15-17,25-26H,12-14H2,1-3H3 LKHXABWGAXRVIH-UHFFFAOYSA-N 105858 US8575197, I-368 P2X purinoceptor 3 Homo sapiens 16 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105858 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105858&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808493 174008169 ZINC96176720 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224454 COCCOc1cc(F)ccc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1noc(C)n1 InChI=1S/C26H26FN3O6/c1-14(2)23(31)21-22(19-10-7-17(27)13-20(19)35-12-11-34-4)30(26(33)24(21)32)18-8-5-16(6-9-18)25-28-15(3)36-29-25/h5-10,13-14,21-22H,11-12H2,1-4H3 VOIPWCSYFDMQRG-UHFFFAOYSA-N 105859 US8575197, I-369 P2X purinoceptor 3 Homo sapiens 91 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105859 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105859&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808494 174008170 ZINC96176721 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224455 CC(C)CC(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1cc(C)no1)c1ccccc1OC(C)C InChI=1S/C28H30N2O5/c1-16(2)14-22(31)25-26(21-8-6-7-9-23(21)34-17(3)4)30(28(33)27(25)32)20-12-10-19(11-13-20)24-15-18(5)29-35-24/h6-13,15-17,25-26H,14H2,1-5H3 SUYMCBLTTLJKJN-UHFFFAOYSA-N 105860 US8575197, I-370 P2X purinoceptor 3 Homo sapiens 194 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105860 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105860&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808495 174008171 ZINC96176722 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224363 CC(C)CC(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1noc(C)n1)c1ccccc1OCC#N InChI=1S/C26H24N4O5/c1-15(2)14-20(31)22-23(19-6-4-5-7-21(19)34-13-12-27)30(26(33)24(22)32)18-10-8-17(9-11-18)25-28-16(3)35-29-25/h4-11,15,22-23H,13-14H2,1-3H3 OCGCVKJTAJIQDJ-UHFFFAOYSA-N 106000 US8575197, I-510 P2X purinoceptor 3 Homo sapiens 174 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106000 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106000&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808623 174008311 ZINC96176861 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224456 COc1ncccc1C1C(C(=O)CC(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1csc(C)c1 InChI=1S/C26H26N2O4S/c1-15(2)12-21(29)22-23(20-6-5-11-27-25(20)32-4)28(26(31)24(22)30)19-9-7-17(8-10-19)18-13-16(3)33-14-18/h5-11,13-15,22-23H,12H2,1-4H3 AMGBRGBAMNFBDL-UHFFFAOYSA-N 105861 US8575197, I-371 P2X purinoceptor 3 Homo sapiens 447 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105861 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105861&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808496 174008172 ZINC96176723 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224457 COCOc1ccccc1C1C(C(=O)CC(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1csc(C)c1 InChI=1S/C28H29NO5S/c1-17(2)13-23(30)25-26(22-7-5-6-8-24(22)34-16-33-4)29(28(32)27(25)31)21-11-9-19(10-12-21)20-14-18(3)35-15-20/h5-12,14-15,17,25-26H,13,16H2,1-4H3 VGDPZYSPNLNGRA-UHFFFAOYSA-N 105862 US8575197, I-372 P2X purinoceptor 3 Homo sapiens 35 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105862 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105862&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808497 174008173 ZINC96176724 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224458 CC(C)CC(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1csc(C)c1)c1ccccc1OC(C)C InChI=1S/C29H31NO4S/c1-17(2)14-24(31)26-27(23-8-6-7-9-25(23)34-18(3)4)30(29(33)28(26)32)22-12-10-20(11-13-22)21-15-19(5)35-16-21/h6-13,15-18,26-27H,14H2,1-5H3 VSCWXXLSQWHNDQ-UHFFFAOYSA-N 105863 US8575197, I-373 P2X purinoceptor 3 Homo sapiens 51 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105863 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105863&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808498 174008174 ZINC96176725 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224459 CC(C)CC(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1csc(C)c1)c1ccccc1OCCO InChI=1S/C28H29NO5S/c1-17(2)14-23(31)25-26(22-6-4-5-7-24(22)34-13-12-30)29(28(33)27(25)32)21-10-8-19(9-11-21)20-15-18(3)35-16-20/h4-11,15-17,25-26,30H,12-14H2,1-3H3 CFQMAXKBAWBIDJ-UHFFFAOYSA-N 105864 US8575197, I-374 P2X purinoceptor 3 Homo sapiens 40 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105864 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105864&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808499 174008175 ZINC96176726 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224460 COCCOc1ccccc1C1C(C(=O)CC(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1csc(C)c1 InChI=1S/C29H31NO5S/c1-18(2)15-24(31)26-27(23-7-5-6-8-25(23)35-14-13-34-4)30(29(33)28(26)32)22-11-9-20(10-12-22)21-16-19(3)36-17-21/h5-12,16-18,26-27H,13-15H2,1-4H3 QEWQEZIOKXTKMW-UHFFFAOYSA-N 105865 US8575197, I-375 P2X purinoceptor 3 Homo sapiens 30 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105865 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105865&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808500 174008176 ZINC96176727 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224461 COCc1ccccc1C1C(C(=O)CC(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1csc(C)c1 InChI=1S/C28H29NO4S/c1-17(2)13-24(30)25-26(23-8-6-5-7-20(23)15-33-4)29(28(32)27(25)31)22-11-9-19(10-12-22)21-14-18(3)34-16-21/h5-12,14,16-17,25-26H,13,15H2,1-4H3 LXVXKAMSOJFKLN-UHFFFAOYSA-N 105866 US8575197, I-376 P2X purinoceptor 3 Homo sapiens 2.5e+2 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105866 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105866&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808501 174008177 ZINC96176728 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224462 CC(C)CC(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1csc(C)c1)c1ccccc1OC(F)F InChI=1S/C27H25F2NO4S/c1-15(2)12-21(31)23-24(20-6-4-5-7-22(20)34-27(28)29)30(26(33)25(23)32)19-10-8-17(9-11-19)18-13-16(3)35-14-18/h4-11,13-15,23-24,27H,12H2,1-3H3 HIMPGSYBADBROJ-UHFFFAOYSA-N 105867 US8575197, I-377 P2X purinoceptor 3 Homo sapiens 148 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105867 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105867&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808502 174008178 ZINC96176729 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224463 CC(C)CC(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1csc(C)c1)c1ccccc1OC(F)(F)F InChI=1S/C27H24F3NO4S/c1-15(2)12-21(32)23-24(20-6-4-5-7-22(20)35-27(28,29)30)31(26(34)25(23)33)19-10-8-17(9-11-19)18-13-16(3)36-14-18/h4-11,13-15,23-24H,12H2,1-3H3 ARKSTEFJRVTLLL-UHFFFAOYSA-N 105868 US8575197, I-378 P2X purinoceptor 3 Homo sapiens 192 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105868 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105868&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808503 174008179 ZINC96176730 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224464 COc1ccccc1C1C(C(=O)CC(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1csc(C)c1 InChI=1S/C27H27NO4S/c1-16(2)13-22(29)24-25(21-7-5-6-8-23(21)32-4)28(27(31)26(24)30)20-11-9-18(10-12-20)19-14-17(3)33-15-19/h5-12,14-16,24-25H,13H2,1-4H3 YTEFPZPGMFQTBQ-UHFFFAOYSA-N 105869 US8575197, I-379 P2X purinoceptor 3 Homo sapiens 118 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105869 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105869&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808504 174008180 ZINC96176731 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224465 COCc1ccccc1C1C(C(=O)CC(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccc(C)o1 InChI=1S/C28H29NO5/c1-17(2)15-23(30)25-26(22-8-6-5-7-20(22)16-33-4)29(28(32)27(25)31)21-12-10-19(11-13-21)24-14-9-18(3)34-24/h5-14,17,25-26H,15-16H2,1-4H3 IQTKFZLBFRXVFW-UHFFFAOYSA-N 105870 US8575197, I-380 P2X purinoceptor 3 Homo sapiens 7 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105870 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105870&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808505 174008181 ZINC96176732 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224466 COCCOc1ccccc1C1C(C(=O)CC(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccc(C)o1 InChI=1S/C29H31NO6/c1-18(2)17-23(31)26-27(22-7-5-6-8-25(22)35-16-15-34-4)30(29(33)28(26)32)21-12-10-20(11-13-21)24-14-9-19(3)36-24/h5-14,18,26-27H,15-17H2,1-4H3 ZTVYUCKLNPZVGG-UHFFFAOYSA-N 105871 US8575197, I-381 P2X purinoceptor 3 Homo sapiens 7 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105871 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105871&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808506 174008182 ZINC96176733 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224467 COCOc1ccccc1C1C(C(=O)CC(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccc(C)o1 InChI=1S/C28H29NO6/c1-17(2)15-22(30)25-26(21-7-5-6-8-24(21)34-16-33-4)29(28(32)27(25)31)20-12-10-19(11-13-20)23-14-9-18(3)35-23/h5-14,17,25-26H,15-16H2,1-4H3 BUHSHKJMVJBYJI-UHFFFAOYSA-N 105872 US8575197, I-382 P2X purinoceptor 3 Homo sapiens 6 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105872 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105872&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808507 174008183 ZINC96176734 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224468 COCCOc1ncccc1C1C(C(=O)C2CCCC2)C(=O)C(=O)N1c1ccc(cc1)-c1ccsc1 InChI=1S/C28H28N2O5S/c1-34-14-15-35-27-22(7-4-13-29-27)24-23(25(31)19-5-2-3-6-19)26(32)28(33)30(24)21-10-8-18(9-11-21)20-12-16-36-17-20/h4,7-13,16-17,19,23-24H,2-3,5-6,14-15H2,1H3 OJMDCDXZFRWSCX-UHFFFAOYSA-N 106007 US8575197, I-517 P2X purinoceptor 3 Homo sapiens 26 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106007 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106007&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808630 174008318 ZINC96176868 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224469 CC(C)Oc1ccccc1C1C(C(=O)C2CCCC2)C(=O)C(=O)N1c1ccc(cc1)-c1noc(C)n1 InChI=1S/C28H29N3O5/c1-16(2)35-22-11-7-6-10-21(22)24-23(25(32)18-8-4-5-9-18)26(33)28(34)31(24)20-14-12-19(13-15-20)27-29-17(3)36-30-27/h6-7,10-16,18,23-24H,4-5,8-9H2,1-3H3 DWTYUMIFNLZGBU-UHFFFAOYSA-N 106008 US8575197, I-518 P2X purinoceptor 3 Homo sapiens 87 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106008 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106008&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808631 174008319 ZINC96176869 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224470 CC(C)COc1ccccc1C1C(C(=O)C2CCCC2)C(=O)C(=O)N1c1ccc(cc1)-c1noc(C)n1 InChI=1S/C29H31N3O5/c1-17(2)16-36-23-11-7-6-10-22(23)25-24(26(33)19-8-4-5-9-19)27(34)29(35)32(25)21-14-12-20(13-15-21)28-30-18(3)37-31-28/h6-7,10-15,17,19,24-25H,4-5,8-9,16H2,1-3H3 YMQRKYQPAORLQK-UHFFFAOYSA-N 106009 US8575197, I-519 P2X purinoceptor 3 Homo sapiens 33 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106009 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106009&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808632 174008320 ZINC96176870 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224471 COCCOc1ncccc1C1C(C(=O)C2CCCC2)C(=O)C(=O)N1c1ccc(cc1)-c1ccon1 InChI=1S/C27H27N3O6/c1-34-15-16-35-26-20(7-4-13-28-26)23-22(24(31)18-5-2-3-6-18)25(32)27(33)30(23)19-10-8-17(9-11-19)21-12-14-36-29-21/h4,7-14,18,22-23H,2-3,5-6,15-16H2,1H3 CFUKEXXUXKVCLB-UHFFFAOYSA-N 106011 US8575197, I-521 P2X purinoceptor 3 Homo sapiens 554 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106011 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106011&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808633 174008322 ZINC96176872 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224472 COCCOc1ncccc1C1C(C(=O)C2CCCC2)C(=O)C(=O)N1c1ccc(cc1)-c1noc(C)n1 InChI=1S/C27H28N4O6/c1-16-29-25(30-37-16)18-9-11-19(12-10-18)31-22(20-8-5-13-28-26(20)36-15-14-35-2)21(24(33)27(31)34)23(32)17-6-3-4-7-17/h5,8-13,17,21-22H,3-4,6-7,14-15H2,1-2H3 ILHBUXWHWVJBHQ-UHFFFAOYSA-N 106013 US8575197, I-523 P2X purinoceptor 3 Homo sapiens 351 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106013 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106013&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808634 174008324 ZINC96176874 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224473 CC(C)C(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1noc(C)n1)c1cccnc1N1CCOCC1 InChI=1S/C26H27N5O5/c1-15(2)22(32)20-21(19-5-4-10-27-25(19)30-11-13-35-14-12-30)31(26(34)23(20)33)18-8-6-17(7-9-18)24-28-16(3)36-29-24/h4-10,15,20-21H,11-14H2,1-3H3 AJRRZUQYBDBDIC-UHFFFAOYSA-N 106014 US8575197, I-524 P2X purinoceptor 3 Homo sapiens 696 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106014 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106014&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808635 174008325 ZINC96176875 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224474 CC(C)C(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1ccsc1)c1cccnc1N1CCOCC1 InChI=1S/C27H27N3O4S/c1-17(2)24(31)22-23(21-4-3-10-28-26(21)29-11-13-34-14-12-29)30(27(33)25(22)32)20-7-5-18(6-8-20)19-9-15-35-16-19/h3-10,15-17,22-23H,11-14H2,1-2H3 COAXCSXMJAQMPD-UHFFFAOYSA-N 106015 US8575197, I-525 P2X purinoceptor 3 Homo sapiens 18 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106015 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106015&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808636 174008326 ZINC96176876 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224475 CC(C)C(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1csc(C)c1)c1ccccc1CC(=O)N1CCCC1 InChI=1S/C31H32N2O4S/c1-19(2)29(35)27-28(25-9-5-4-8-22(25)17-26(34)32-14-6-7-15-32)33(31(37)30(27)36)24-12-10-21(11-13-24)23-16-20(3)38-18-23/h4-5,8-13,16,18-19,27-28H,6-7,14-15,17H2,1-3H3 TZIMETHCTSAIIS-UHFFFAOYSA-N 106016 US8575197, I-526 P2X purinoceptor 3 Homo sapiens 219 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106016 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106016&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808637 174008327 ZINC96176877 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224476 COCc1ccccc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)C1=CCCC1 InChI=1S/C27H29NO4/c1-17(2)25(29)23-24(22-11-7-6-10-20(22)16-32-3)28(27(31)26(23)30)21-14-12-19(13-15-21)18-8-4-5-9-18/h6-8,10-15,17,23-24H,4-5,9,16H2,1-3H3 UTNLYNKGTOGPGR-UHFFFAOYSA-N 106017 US8575197, I-527 P2X purinoceptor 3 Homo sapiens 39 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106017 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106017&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808638 174008328 ZINC96176878 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224477 COCc1ccccc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)C1CCCC1 InChI=1S/C27H31NO4/c1-17(2)25(29)23-24(22-11-7-6-10-20(22)16-32-3)28(27(31)26(23)30)21-14-12-19(13-15-21)18-8-4-5-9-18/h6-7,10-15,17-18,23-24H,4-5,8-9,16H2,1-3H3 VURKUYDYGVBEPS-UHFFFAOYSA-N 106018 US8575197, I-528 P2X purinoceptor 3 Homo sapiens 70 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106018 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106018&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808639 174008329 ZINC96176879 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224478 CCNC(=O)c1ncccc1C1C(C(=O)CC(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccc(C)s1 InChI=1S/C28H29N3O4S/c1-5-29-27(34)24-20(7-6-14-30-24)25-23(21(32)15-16(2)3)26(33)28(35)31(25)19-11-9-18(10-12-19)22-13-8-17(4)36-22/h6-14,16,23,25H,5,15H2,1-4H3,(H,29,34) ZGCAJPUZVIVAHH-UHFFFAOYSA-N 106020 US8575197, I-530 P2X purinoceptor 3 Homo sapiens 237 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106020 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106020&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808640 174008331 ZINC96176881 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224479 COc1ccccc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1csnn1 InChI=1S/C23H21N3O4S/c1-13(2)21(27)19-20(16-6-4-5-7-18(16)30-3)26(23(29)22(19)28)15-10-8-14(9-11-15)17-12-31-25-24-17/h4-13,19-20H,1-3H3 WINOGBIGQXJWOP-UHFFFAOYSA-N 106021 US8575197, I-531 P2X purinoceptor 3 Homo sapiens 286 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106021 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106021&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808641 174008332 ZINC96176882 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224480 COCCOc1ccccc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1csnn1 InChI=1S/C25H25N3O5S/c1-15(2)23(29)21-22(18-6-4-5-7-20(18)33-13-12-32-3)28(25(31)24(21)30)17-10-8-16(9-11-17)19-14-34-27-26-19/h4-11,14-15,21-22H,12-13H2,1-3H3 FYGWOVLFPBULFM-UHFFFAOYSA-N 106022 US8575197, I-532 P2X purinoceptor 3 Homo sapiens 204 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106022 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106022&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808642 174008333 ZINC96176883 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224481 CC(C)Oc1ccccc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1csnn1 InChI=1S/C25H25N3O4S/c1-14(2)23(29)21-22(18-7-5-6-8-20(18)32-15(3)4)28(25(31)24(21)30)17-11-9-16(10-12-17)19-13-33-27-26-19/h5-15,21-22H,1-4H3 MSQUHKPPWOQHIT-UHFFFAOYSA-N 106023 US8575197, I-533 P2X purinoceptor 3 Homo sapiens 33 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106023 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106023&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808643 174008334 ZINC96176884 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224482 CNC(=O)CCc1ccccc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccc(C)o1 InChI=1S/C29H30N2O5/c1-17(2)27(33)25-26(22-8-6-5-7-19(22)12-16-24(32)30-4)31(29(35)28(25)34)21-13-10-20(11-14-21)23-15-9-18(3)36-23/h5-11,13-15,17,25-26H,12,16H2,1-4H3,(H,30,32) FUCYCVHNNUTESR-UHFFFAOYSA-N 106025 US8575197, I-535 P2X purinoceptor 3 Homo sapiens 49 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106025 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106025&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808644 174008336 ZINC96176886 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224483 CC(C)C(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1ccc(C)o1)c1ccccc1CCC(N)=O InChI=1S/C28H28N2O5/c1-16(2)26(32)24-25(21-7-5-4-6-18(21)11-15-23(29)31)30(28(34)27(24)33)20-12-9-19(10-13-20)22-14-8-17(3)35-22/h4-10,12-14,16,24-25H,11,15H2,1-3H3,(H2,29,31) GVNLZMCARKJTTK-UHFFFAOYSA-N 106026 US8575197, I-536 P2X purinoceptor 3 Homo sapiens 32 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106026 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106026&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808645 174008337 ZINC96176887 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224484 CC(C)C(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1ccc(C)o1)c1ccccc1CCC(=O)N(C)C InChI=1S/C30H32N2O5/c1-18(2)28(34)26-27(23-9-7-6-8-20(23)13-17-25(33)31(4)5)32(30(36)29(26)35)22-14-11-21(12-15-22)24-16-10-19(3)37-24/h6-12,14-16,18,26-27H,13,17H2,1-5H3 RSGUGMKSZPUJSI-UHFFFAOYSA-N 106027 US8575197, I-537 P2X purinoceptor 3 Homo sapiens 83 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106027 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106027&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808646 174008338 ZINC96176888 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224485 CC(C)NC(=O)CCc1ccccc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccc(C)o1 InChI=1S/C31H34N2O5/c1-18(2)29(35)27-28(24-9-7-6-8-21(24)13-17-26(34)32-19(3)4)33(31(37)30(27)36)23-14-11-22(12-15-23)25-16-10-20(5)38-25/h6-12,14-16,18-19,27-28H,13,17H2,1-5H3,(H,32,34) UMPWSBHQMHQMDQ-UHFFFAOYSA-N 106028 US8575197, I-538 P2X purinoceptor 3 Homo sapiens 119 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106028 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106028&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808647 174008339 ZINC96176889 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224486 CC(C)OCc1ccccc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1noc(C)n1 InChI=1S/C27H29N3O5/c1-15(2)24(31)22-23(21-9-7-6-8-19(21)14-34-16(3)4)30(27(33)25(22)32)20-12-10-18(11-13-20)26-28-17(5)35-29-26/h6-13,15-16,22-23H,14H2,1-5H3 OJOVGEWECDWIGO-UHFFFAOYSA-N 106029 US8575197, I-539 P2X purinoceptor 3 Homo sapiens 62 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106029 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106029&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808648 174008340 ZINC96176890 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224487 CC(C)OCc1ccccc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccon1 InChI=1S/C27H28N2O5/c1-16(2)25(30)23-24(21-8-6-5-7-19(21)15-33-17(3)4)29(27(32)26(23)31)20-11-9-18(10-12-20)22-13-14-34-28-22/h5-14,16-17,23-24H,15H2,1-4H3 MKPZYSQTJQSPEH-UHFFFAOYSA-N 106030 US8575197, I-540 P2X purinoceptor 3 Homo sapiens 496 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106030 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106030&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808649 174008341 ZINC96176891 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224488 CC(C)OCc1ccccc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccsc1 InChI=1S/C28H29NO4S/c1-17(2)26(30)24-25(23-8-6-5-7-20(23)15-33-18(3)4)29(28(32)27(24)31)22-11-9-19(10-12-22)21-13-14-34-16-21/h5-14,16-18,24-25H,15H2,1-4H3 JUYZNRQKXUURIN-UHFFFAOYSA-N 106031 US8575197, I-541 P2X purinoceptor 3 Homo sapiens 10 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106031 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106031&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808650 174008342 ZINC96176892 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224489 CCOCOc1ccccc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1noc(C)n1 InChI=1S/C26H27N3O6/c1-5-33-14-34-20-9-7-6-8-19(20)22-21(23(30)15(2)3)24(31)26(32)29(22)18-12-10-17(11-13-18)25-27-16(4)35-28-25/h6-13,15,21-22H,5,14H2,1-4H3 HYLCHUWSFDHNEZ-UHFFFAOYSA-N 106032 US8575197, I-542 P2X purinoceptor 3 Homo sapiens 58 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106032 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106032&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808651 174008343 ZINC96176893 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224490 CCOCOc1ccccc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccon1 InChI=1S/C26H26N2O6/c1-4-32-15-33-21-8-6-5-7-19(21)23-22(24(29)16(2)3)25(30)26(31)28(23)18-11-9-17(10-12-18)20-13-14-34-27-20/h5-14,16,22-23H,4,15H2,1-3H3 FZVDJKNMPQFWSB-UHFFFAOYSA-N 106033 US8575197, I-543 P2X purinoceptor 3 Homo sapiens 240 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106033 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106033&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808652 174008344 ZINC96176894 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224491 CCOCOc1ccccc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccsc1 InChI=1S/C27H27NO5S/c1-4-32-16-33-22-8-6-5-7-21(22)24-23(25(29)17(2)3)26(30)27(31)28(24)20-11-9-18(10-12-20)19-13-14-34-15-19/h5-15,17,23-24H,4,16H2,1-3H3 DFNKZHXDRKATOE-UHFFFAOYSA-N 106034 US8575197, I-544 P2X purinoceptor 3 Homo sapiens 8 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106034 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106034&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808653 174008345 ZINC96176895 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224492 CCOCOc1ccccc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1nc(C)no1 InChI=1S/C26H27N3O6/c1-5-33-14-34-20-9-7-6-8-19(20)22-21(23(30)15(2)3)24(31)26(32)29(22)18-12-10-17(11-13-18)25-27-16(4)28-35-25/h6-13,15,21-22H,5,14H2,1-4H3 MAHCGSKWRPIGLE-UHFFFAOYSA-N 106035 US8575197, I-545 P2X purinoceptor 3 Homo sapiens 142 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106035 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106035&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808654 174008346 ZINC96176896 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224493 CC(C)C(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1csc(C)c1)c1ccccc1C(=O)N1CCOCC1 InChI=1S/C30H30N2O5S/c1-18(2)27(33)25-26(23-6-4-5-7-24(23)29(35)31-12-14-37-15-13-31)32(30(36)28(25)34)22-10-8-20(9-11-22)21-16-19(3)38-17-21/h4-11,16-18,25-26H,12-15H2,1-3H3 LIMKOLWRTOHFJA-UHFFFAOYSA-N 106036 US8575197, I-546 P2X purinoceptor 3 Homo sapiens 395 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106036 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106036&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808655 174008347 ZINC96176897 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224494 COCCN(C)C(=O)c1ccccc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1csc(C)c1 InChI=1S/C30H32N2O5S/c1-18(2)27(33)25-26(23-8-6-7-9-24(23)29(35)31(4)14-15-37-5)32(30(36)28(25)34)22-12-10-20(11-13-22)21-16-19(3)38-17-21/h6-13,16-18,25-26H,14-15H2,1-5H3 JMDYZEPSOOVNRQ-UHFFFAOYSA-N 106037 US8575197, I-547 P2X purinoceptor 3 Homo sapiens 217 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106037 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106037&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808656 174008348 ZINC96176898 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224495 CC(C)C(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1ccc(C)o1)c1ccccc1S(C)(=O)=O InChI=1S/C26H25NO6S/c1-15(2)24(28)22-23(19-7-5-6-8-21(19)34(4,31)32)27(26(30)25(22)29)18-12-10-17(11-13-18)20-14-9-16(3)33-20/h5-15,22-23H,1-4H3 PHZQMMYDZVQLJA-UHFFFAOYSA-N 106038 US8575197, I-548 P2X purinoceptor 3 Homo sapiens 77 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106038 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106038&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808657 174008349 ZINC96176899 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224496 CC(C)C(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1ccc(C)o1)c1ccccc1C(=O)N1CCOCC1 InChI=1S/C30H30N2O6/c1-18(2)27(33)25-26(22-6-4-5-7-23(22)29(35)31-14-16-37-17-15-31)32(30(36)28(25)34)21-11-9-20(10-12-21)24-13-8-19(3)38-24/h4-13,18,25-26H,14-17H2,1-3H3 ODXNXQDRNKHLPZ-UHFFFAOYSA-N 106039 US8575197, I-549 P2X purinoceptor 3 Homo sapiens 213 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106039 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106039&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808658 174008350 ZINC96176900 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224497 COCCOc1ncccc1C1C(C(=O)CC(C)C)C(=O)C(=O)N1c1ccc(SC)cc1 InChI=1S/C24H28N2O5S/c1-15(2)14-19(27)20-21(18-6-5-11-25-23(18)31-13-12-30-3)26(24(29)22(20)28)16-7-9-17(32-4)10-8-16/h5-11,15,20-21H,12-14H2,1-4H3 SXWHVKRXHQHWJP-UHFFFAOYSA-N 106040 US8575197, I-550 P2X purinoceptor 3 Homo sapiens 254 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106040 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106040&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808659 174008351 ZINC96176901 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224498 CC(C)C(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1ccsc1)c1ccccc1OCC1OCCO1 InChI=1S/C28H27NO6S/c1-17(2)26(30)24-25(21-5-3-4-6-22(21)35-15-23-33-12-13-34-23)29(28(32)27(24)31)20-9-7-18(8-10-20)19-11-14-36-16-19/h3-11,14,16-17,23-25H,12-13,15H2,1-2H3 SLDZAWLUACADND-UHFFFAOYSA-N 106041 US8575197, I-551 P2X purinoceptor 3 Homo sapiens 5 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106041 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106041&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808660 174008352 ZINC96176902 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224499 CC(C)OCc1ccccc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1nc(C)no1 InChI=1S/C27H29N3O5/c1-15(2)24(31)22-23(21-9-7-6-8-19(21)14-34-16(3)4)30(27(33)25(22)32)20-12-10-18(11-13-20)26-28-17(5)29-35-26/h6-13,15-16,22-23H,14H2,1-5H3 KFSJFGNSRGVBME-UHFFFAOYSA-N 106042 US8575197, I-552 P2X purinoceptor 3 Homo sapiens 186 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106042 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106042&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808661 174008353 ZINC96176903 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224500 COc1ccccc1C1C(C(=O)c2cc[nH]c2)C(=O)C(=O)N1c1ccc(cc1)-c1csc(C)c1 InChI=1S/C27H22N2O4S/c1-16-13-19(15-34-16)17-7-9-20(10-8-17)29-24(21-5-3-4-6-22(21)33-2)23(26(31)27(29)32)25(30)18-11-12-28-14-18/h3-15,23-24,28H,1-2H3 SXVUXZIXKNQBFH-UHFFFAOYSA-N 106043 US8575197, I-553 P2X purinoceptor 3 Homo sapiens 337 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106043 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106043&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808662 174008354 ZINC96176904 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224501 Cc1nc(no1)-c1ccc(cc1)N1C(C(C(=O)c2cc[nH]c2)C(=O)C1=O)C1CCCCC1 InChI=1S/C24H24N4O4/c1-14-26-23(27-32-14)16-7-9-18(10-8-16)28-20(15-5-3-2-4-6-15)19(22(30)24(28)31)21(29)17-11-12-25-13-17/h7-13,15,19-20,25H,2-6H2,1H3 LMXRRFJERDETGQ-UHFFFAOYSA-N 106045 US8575197, I-555 P2X purinoceptor 3 Homo sapiens 579 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106045 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106045&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808663 174008356 ZINC96176906 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224502 COC(=O)C(C)(C)CC(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1ccsc1)c1ccccc1OC InChI=1S/C28H27NO6S/c1-28(2,27(33)35-4)15-21(30)23-24(20-7-5-6-8-22(20)34-3)29(26(32)25(23)31)19-11-9-17(10-12-19)18-13-14-36-16-18/h5-14,16,23-24H,15H2,1-4H3 HCLSMWLRQWRYFK-UHFFFAOYSA-N 106046 US8575197, I-556 P2X purinoceptor 3 Homo sapiens 32 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106046 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106046&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808664 174008357 ZINC96176907 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224503 COc1ccccc1C1C(C(=O)CC(C)(C)C(O)=O)C(=O)C(=O)N1c1ccc(cc1)-c1ccsc1 InChI=1S/C27H25NO6S/c1-27(2,26(32)33)14-20(29)22-23(19-6-4-5-7-21(19)34-3)28(25(31)24(22)30)18-10-8-16(9-11-18)17-12-13-35-15-17/h4-13,15,22-23H,14H2,1-3H3,(H,32,33) NUNLNEMFOKWACI-UHFFFAOYSA-N 106047 US8575197, I-557 P2X purinoceptor 3 Homo sapiens 444 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106047 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106047&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808665 174008358 ZINC96176908 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224504 CSc1ccccc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccsc1 InChI=1S/C25H23NO3S2/c1-15(2)23(27)21-22(19-6-4-5-7-20(19)30-3)26(25(29)24(21)28)18-10-8-16(9-11-18)17-12-13-31-14-17/h4-15,21-22H,1-3H3 UNWFXORQKWJUDQ-UHFFFAOYSA-N 106048 US8575197, I-558 P2X purinoceptor 3 Homo sapiens 8 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106048 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106048&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808666 174008359 ZINC96176909 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224505 CSc1ccccc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1csc(C)c1 InChI=1S/C26H25NO3S2/c1-15(2)24(28)22-23(20-7-5-6-8-21(20)31-4)27(26(30)25(22)29)19-11-9-17(10-12-19)18-13-16(3)32-14-18/h5-15,22-23H,1-4H3 BEDKUORFBQOTKE-UHFFFAOYSA-N 106049 US8575197, I-559 P2X purinoceptor 3 Homo sapiens 40 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106049 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106049&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808667 174008360 ZINC96176910 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224506 COc1ccc(cc1)S(=O)(=O)C1C(C2CCCCC2)N(C(=O)C1=O)c1ccc(cc1)-c1noc(C)n1 InChI=1S/C26H27N3O6S/c1-16-27-25(28-35-16)18-8-10-19(11-9-18)29-22(17-6-4-3-5-7-17)24(23(30)26(29)31)36(32,33)21-14-12-20(34-2)13-15-21/h8-15,17,22,24H,3-7H2,1-2H3 QRMPOCRDIMLCIS-UHFFFAOYSA-N 106050 US8575197, I-560 P2X purinoceptor 3 Homo sapiens 275 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106050 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106050&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808668 174008361 ZINC96176911 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224507 COc1ccccc1C1C(C(=O)C(=O)N1c1ccc(cc1)-c1ccsc1)S(=O)(=O)C(C)C InChI=1S/C24H23NO5S2/c1-15(2)32(28,29)23-21(19-6-4-5-7-20(19)30-3)25(24(27)22(23)26)18-10-8-16(9-11-18)17-12-13-31-14-17/h4-15,21,23H,1-3H3 LQUZRAKUWZBQIJ-UHFFFAOYSA-N 106052 US8575197, I-562 P2X purinoceptor 3 Homo sapiens 101 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106052 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106052&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808669 174008363 ZINC96176913 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224508 COCCOc1ccccc1C1C(C(=O)C(=O)N1c1ccc(cc1)-c1ccsc1)S(=O)(=O)C(C)C InChI=1S/C26H27NO6S2/c1-17(2)35(30,31)25-23(21-6-4-5-7-22(21)33-14-13-32-3)27(26(29)24(25)28)20-10-8-18(9-11-20)19-12-15-34-16-19/h4-12,15-17,23,25H,13-14H2,1-3H3 LHHCBPJQPMFWGL-UHFFFAOYSA-N 106053 US8575197, I-563 P2X purinoceptor 3 Homo sapiens 42 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106053 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106053&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808670 174008364 ZINC96176914 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224509 CC(C)C(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1ccsc1)c1cccnc1OCCCO InChI=1S/C26H26N2O5S/c1-16(2)23(30)21-22(20-5-3-11-27-25(20)33-13-4-12-29)28(26(32)24(21)31)19-8-6-17(7-9-19)18-10-14-34-15-18/h3,5-11,14-16,21-22,29H,4,12-13H2,1-2H3 DSNFZYHIBCAQJG-UHFFFAOYSA-N 106054 US8575197, I-564 P2X purinoceptor 3 Homo sapiens 18 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106054 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106054&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808671 174008365 ZINC96176915 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224510 COCCCOc1ncccc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccsc1 InChI=1S/C27H28N2O5S/c1-17(2)24(30)22-23(21-6-4-12-28-26(21)34-14-5-13-33-3)29(27(32)25(22)31)20-9-7-18(8-10-20)19-11-15-35-16-19/h4,6-12,15-17,22-23H,5,13-14H2,1-3H3 ZIOLTXFNHGPWRY-UHFFFAOYSA-N 106055 US8575197, I-565 P2X purinoceptor 3 Homo sapiens 13 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106055 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106055&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808672 174008366 ZINC96176916 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224511 CC(C)C(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1ccoc1)c1cccnc1OCCCO InChI=1S/C26H26N2O6/c1-16(2)23(30)21-22(20-5-3-11-27-25(20)34-13-4-12-29)28(26(32)24(21)31)19-8-6-17(7-9-19)18-10-14-33-15-18/h3,5-11,14-16,21-22,29H,4,12-13H2,1-2H3 HLEFLACIXPVUBB-UHFFFAOYSA-N 106056 US8575197, I-566 P2X purinoceptor 3 Homo sapiens 61 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106056 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106056&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808673 174008367 ZINC96176917 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224512 COCCCOc1ncccc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccoc1 InChI=1S/C27H28N2O6/c1-17(2)24(30)22-23(21-6-4-12-28-26(21)35-14-5-13-33-3)29(27(32)25(22)31)20-9-7-18(8-10-20)19-11-15-34-16-19/h4,6-12,15-17,22-23H,5,13-14H2,1-3H3 OWCRQTNJUZKZEH-UHFFFAOYSA-N 106057 US8575197, I-567 P2X purinoceptor 3 Homo sapiens 57 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106057 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106057&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808674 174008368 ZINC96176918 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224513 CC(C)C(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1ccc(C)s1)c1cccnc1OCCCO InChI=1S/C27H28N2O5S/c1-16(2)24(31)22-23(20-6-4-13-28-26(20)34-15-5-14-30)29(27(33)25(22)32)19-10-8-18(9-11-19)21-12-7-17(3)35-21/h4,6-13,16,22-23,30H,5,14-15H2,1-3H3 RJVOTTGHTVIXTC-UHFFFAOYSA-N 106058 US8575197, I-568 P2X purinoceptor 3 Homo sapiens 66 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106058 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106058&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808675 174008369 ZINC96176919 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224514 COCCCOc1ncccc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccc(C)s1 InChI=1S/C28H30N2O5S/c1-17(2)25(31)23-24(21-7-5-14-29-27(21)35-16-6-15-34-4)30(28(33)26(23)32)20-11-9-19(10-12-20)22-13-8-18(3)36-22/h5,7-14,17,23-24H,6,15-16H2,1-4H3 PAYUPMDZXNJZNZ-UHFFFAOYSA-N 106059 US8575197, I-569 P2X purinoceptor 3 Homo sapiens 35 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106059 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106059&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808676 174008370 ZINC96176920 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224515 CC(C)C(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1csc(C)c1)c1cccnc1OCCCO InChI=1S/C27H28N2O5S/c1-16(2)24(31)22-23(21-6-4-11-28-26(21)34-13-5-12-30)29(27(33)25(22)32)20-9-7-18(8-10-20)19-14-17(3)35-15-19/h4,6-11,14-16,22-23,30H,5,12-13H2,1-3H3 LEFRMCCOAKONPL-UHFFFAOYSA-N 106060 US8575197, I-570 P2X purinoceptor 3 Homo sapiens 70 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106060 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106060&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808677 174008371 ZINC96176921 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224516 COCCCOc1ncccc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1csc(C)c1 InChI=1S/C28H30N2O5S/c1-17(2)25(31)23-24(22-7-5-12-29-27(22)35-14-6-13-34-4)30(28(33)26(23)32)21-10-8-19(9-11-21)20-15-18(3)36-16-20/h5,7-12,15-17,23-24H,6,13-14H2,1-4H3 KSINMFIWFMBYFM-UHFFFAOYSA-N 106061 US8575197, I-571 P2X purinoceptor 3 Homo sapiens 60 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106061 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106061&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808678 174008372 ZINC96176922 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224517 CNC(=O)COc1ncccc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccsc1 InChI=1S/C26H25N3O5S/c1-15(2)23(31)21-22(19-5-4-11-28-25(19)34-13-20(30)27-3)29(26(33)24(21)32)18-8-6-16(7-9-18)17-10-12-35-14-17/h4-12,14-15,21-22H,13H2,1-3H3,(H,27,30) FIFIJRWQIFUUTN-UHFFFAOYSA-N 105689 US8575197, I-199 P2X purinoceptor 3 Homo sapiens 19 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105689 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105689&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808338 174008000 ZINC96176556 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224518 CC(C)C(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1ccsc1)c1cccnc1OCC(N)=O InChI=1S/C25H23N3O5S/c1-14(2)22(30)20-21(18-4-3-10-27-24(18)33-12-19(26)29)28(25(32)23(20)31)17-7-5-15(6-8-17)16-9-11-34-13-16/h3-11,13-14,20-21H,12H2,1-2H3,(H2,26,29) VIRXPEVSCYJREQ-UHFFFAOYSA-N 105690 US8575197, I-200 P2X purinoceptor 3 Homo sapiens 14 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105690 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105690&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808339 174008001 ZINC96176557 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224519 COCCOc1ccccc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccoc1 InChI=1S/C27H27NO6/c1-17(2)25(29)23-24(21-6-4-5-7-22(21)34-15-14-32-3)28(27(31)26(23)30)20-10-8-18(9-11-20)19-12-13-33-16-19/h4-13,16-17,23-24H,14-15H2,1-3H3 JVZUSRZNNQYJGN-UHFFFAOYSA-N 105691 US8575197, I-201 P2X purinoceptor 3 Homo sapiens 39 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105691 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105691&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808340 174008002 ZINC96176558 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224520 COc1ccccc1[C@@H]1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccoc1 InChI=1S/C25H23NO5/c1-15(2)23(27)21-22(19-6-4-5-7-20(19)30-3)26(25(29)24(21)28)18-10-8-16(9-11-18)17-12-13-31-14-17/h4-15,21-22H,1-3H3/t21?,22-/m1/s1 JCYYMPXQRKTVFQ-FOIFJWKZSA-N 105692 US8575197, I-202 P2X purinoceptor 3 Homo sapiens 40 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105692 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105692&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808341 174008003 ZINC96176559 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224521 COCc1ccccc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccoc1 InChI=1S/C26H25NO5/c1-16(2)24(28)22-23(21-7-5-4-6-19(21)14-31-3)27(26(30)25(22)29)20-10-8-17(9-11-20)18-12-13-32-15-18/h4-13,15-16,22-23H,14H2,1-3H3 PQRKLJLOYFWBMY-UHFFFAOYSA-N 105694 US8575197, I-204 P2X purinoceptor 3 Homo sapiens 43 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105694 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105694&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808342 174008005 ZINC96176560 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224522 COc1ccccc1[C@H]1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccsc1 InChI=1S/C25H23NO4S/c1-15(2)23(27)21-22(19-6-4-5-7-20(19)30-3)26(25(29)24(21)28)18-10-8-16(9-11-18)17-12-13-31-14-17/h4-15,21-22H,1-3H3/t21?,22-/m0/s1 JPZAUDGHXGMCOI-KEKNWZKVSA-N 105696 US8575197, I-206 P2X purinoceptor 3 Homo sapiens 630 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105696 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105696&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808343 174008007 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224523 COc1ccccc1[C@@H]1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccsc1 InChI=1S/C25H23NO4S/c1-15(2)23(27)21-22(19-6-4-5-7-20(19)30-3)26(25(29)24(21)28)18-10-8-16(9-11-18)17-12-13-31-14-17/h4-15,21-22H,1-3H3/t21?,22-/m1/s1 JPZAUDGHXGMCOI-FOIFJWKZSA-N 105697 US8575197, I-207 P2X purinoceptor 3 Homo sapiens 8 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105697 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105697&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808344 174008008 ZINC96176562 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224524 COCCOc1ccccc1[C@@H]1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccoc1 InChI=1S/C27H27NO6/c1-17(2)25(29)23-24(21-6-4-5-7-22(21)34-15-14-32-3)28(27(31)26(23)30)20-10-8-18(9-11-20)19-12-13-33-16-19/h4-13,16-17,23-24H,14-15H2,1-3H3/t23?,24-/m1/s1 JVZUSRZNNQYJGN-XMMISQBUSA-N 105698 US8575197, I-208 P2X purinoceptor 3 Homo sapiens 14 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105698 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105698&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808345 174008009 ZINC96176563 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224525 COCCOc1ccccc1[C@H]1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccoc1 InChI=1S/C27H27NO6/c1-17(2)25(29)23-24(21-6-4-5-7-22(21)34-15-14-32-3)28(27(31)26(23)30)20-10-8-18(9-11-20)19-12-13-33-16-19/h4-13,16-17,23-24H,14-15H2,1-3H3/t23?,24-/m0/s1 JVZUSRZNNQYJGN-CGAIIQECSA-N 105699 US8575197, I-209 P2X purinoceptor 3 Homo sapiens 234 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105699 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105699&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808346 174008010 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224526 COc1ccccc1C1C(C(=O)C(C)(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccc(C)s1 InChI=1S/C27H27NO4S/c1-16-10-15-21(33-16)17-11-13-18(14-12-17)28-23(19-8-6-7-9-20(19)32-5)22(24(29)26(28)31)25(30)27(2,3)4/h6-15,22-23H,1-5H3 PBSLVWJUURDVOM-UHFFFAOYSA-N 105700 US8575197, I-210 P2X purinoceptor 3 Homo sapiens 47 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105700 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105700&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808347 174008011 ZINC96176564 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224527 COc1ccccc1C1C(C(=O)c2ccco2)C(=O)C(=O)N1c1ccc(cc1)-c1ccsc1 InChI=1S/C26H19NO5S/c1-31-20-6-3-2-5-19(20)23-22(24(28)21-7-4-13-32-21)25(29)26(30)27(23)18-10-8-16(9-11-18)17-12-14-33-15-17/h2-15,22-23H,1H3 NIZHMGRAAQADOF-UHFFFAOYSA-N 105701 US8575197, I-211 P2X purinoceptor 3 Homo sapiens 157 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105701 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105701&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808348 174008012 ZINC96176565 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224528 CC(C)C(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1ccsc1)c1ccccc1N(C)C(C)=O InChI=1S/C27H26N2O4S/c1-16(2)25(31)23-24(21-7-5-6-8-22(21)28(4)17(3)30)29(27(33)26(23)32)20-11-9-18(10-12-20)19-13-14-34-15-19/h5-16,23-24H,1-4H3 OJUPVJMMWHZIIR-UHFFFAOYSA-N 105702 US8575197, I-212 P2X purinoceptor 3 Homo sapiens 92 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105702 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105702&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808349 174008013 ZINC96176566 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224529 COCOc1ccccc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccsc1 InChI=1S/C26H25NO5S/c1-16(2)24(28)22-23(20-6-4-5-7-21(20)32-15-31-3)27(26(30)25(22)29)19-10-8-17(9-11-19)18-12-13-33-14-18/h4-14,16,22-23H,15H2,1-3H3 JGVPBWVZQHDUJY-UHFFFAOYSA-N 105703 US8575197, I-213 P2X purinoceptor 3 Homo sapiens 6 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105703 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105703&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808350 174008014 ZINC96176567 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224530 COc1ccccc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1cccs1 InChI=1S/C25H23NO4S/c1-15(2)23(27)21-22(18-7-4-5-8-19(18)30-3)26(25(29)24(21)28)17-12-10-16(11-13-17)20-9-6-14-31-20/h4-15,21-22H,1-3H3 PXNVADZFCVEJCW-UHFFFAOYSA-N 105704 US8575197, I-214 P2X purinoceptor 3 Homo sapiens 22 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105704 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105704&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808351 174008015 ZINC96176568 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224531 COCc1ccccc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1cccs1 InChI=1S/C26H25NO4S/c1-16(2)24(28)22-23(20-8-5-4-7-18(20)15-31-3)27(26(30)25(22)29)19-12-10-17(11-13-19)21-9-6-14-32-21/h4-14,16,22-23H,15H2,1-3H3 GGVOWCTWTHVJOQ-UHFFFAOYSA-N 105705 US8575197, I-215 P2X purinoceptor 3 Homo sapiens 13 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105705 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105705&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808352 174008016 ZINC96176569 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224532 CCOC(=O)C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccsc1 InChI=1S/C21H21NO5S/c1-4-27-21(26)17-16(18(23)12(2)3)19(24)20(25)22(17)15-7-5-13(6-8-15)14-9-10-28-11-14/h5-12,16-17H,4H2,1-3H3 NHFDXXPQLBEGNA-UHFFFAOYSA-N 105706 US8575197, I-216 P2X purinoceptor 3 Homo sapiens 679 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105706 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105706&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808353 174008017 ZINC96176570 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224533 CC(C)C(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1ccsc1)c1ccccc1OCc1nnn[nH]1 InChI=1S/C26H23N5O4S/c1-15(2)24(32)22-23(19-5-3-4-6-20(19)35-13-21-27-29-30-28-21)31(26(34)25(22)33)18-9-7-16(8-10-18)17-11-12-36-14-17/h3-12,14-15,22-23H,13H2,1-2H3,(H,27,28,29,30) HMOKYPSJOISPSI-UHFFFAOYSA-N 105707 US8575197, I-217 P2X purinoceptor 3 Homo sapiens 12 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105707 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105707&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808354 174008018 ZINC96176571 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224534 COc1ccccc1C1C(C(=O)C2CC2)C(=O)C(=O)N1c1ccc(cc1)-c1ccsc1 InChI=1S/C25H21NO4S/c1-30-20-5-3-2-4-19(20)22-21(23(27)16-6-7-16)24(28)25(29)26(22)18-10-8-15(9-11-18)17-12-13-31-14-17/h2-5,8-14,16,21-22H,6-7H2,1H3 FZKBOBXQDJXVGR-UHFFFAOYSA-N 105708 US8575197, I-218 P2X purinoceptor 3 Homo sapiens 73 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105708 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105708&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808355 174008019 ZINC96176572 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224535 CC(C)C(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1ccsc1)c1ccccn1 InChI=1S/C23H20N2O3S/c1-14(2)21(26)19-20(18-5-3-4-11-24-18)25(23(28)22(19)27)17-8-6-15(7-9-17)16-10-12-29-13-16/h3-14,19-20H,1-2H3 VHUQCJPWPCRVMF-UHFFFAOYSA-N 105709 US8575197, I-219 P2X purinoceptor 3 Homo sapiens 324 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105709 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105709&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808356 174008020 ZINC96176573 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224536 CC(C)C(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1ccsc1)c1ccccc1OCC(=N)NO InChI=1S/C26H25N3O5S/c1-15(2)24(30)22-23(19-5-3-4-6-20(19)34-13-21(27)28-33)29(26(32)25(22)31)18-9-7-16(8-10-18)17-11-12-35-14-17/h3-12,14-15,22-23,33H,13H2,1-2H3,(H2,27,28) IKDITXHTDMCRRN-UHFFFAOYSA-N 105710 US8575197, I-220 P2X purinoceptor 3 Homo sapiens 5 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105710 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105710&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808357 174008021 ZINC96176574 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224537 COc1ccccc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(-c2ccsc2)c(OC)c1 InChI=1S/C26H25NO5S/c1-15(2)24(28)22-23(19-7-5-6-8-20(19)31-3)27(26(30)25(22)29)17-9-10-18(21(13-17)32-4)16-11-12-33-14-16/h5-15,22-23H,1-4H3 HTVPXRPDSDDWPE-UHFFFAOYSA-N 105711 US8575197, I-221 P2X purinoceptor 3 Homo sapiens 81 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105711 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105711&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808358 174008022 ZINC96176575 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224538 COCCOc1ccccc1[C@@H]1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccsc1 InChI=1S/C27H27NO5S/c1-17(2)25(29)23-24(21-6-4-5-7-22(21)33-14-13-32-3)28(27(31)26(23)30)20-10-8-18(9-11-20)19-12-15-34-16-19/h4-12,15-17,23-24H,13-14H2,1-3H3/t23?,24-/m1/s1 QLVFSDDQDUQTQP-XMMISQBUSA-N 105712 US8575197, I-222 P2X purinoceptor 3 Homo sapiens 6 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105712 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105712&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808359 174008023 ZINC96176576 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224539 CC(C)C(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1cccs1)c1ccccc1OCCO InChI=1S/C26H25NO5S/c1-16(2)24(29)22-23(19-6-3-4-7-20(19)32-14-13-28)27(26(31)25(22)30)18-11-9-17(10-12-18)21-8-5-15-33-21/h3-12,15-16,22-23,28H,13-14H2,1-2H3 WXNDDTSQBUXWCN-UHFFFAOYSA-N 105713 US8575197, I-223 P2X purinoceptor 3 Homo sapiens 12 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105713 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105713&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808360 174008024 ZINC96176577 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224540 COc1ccccc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccco1 InChI=1S/C25H23NO5/c1-15(2)23(27)21-22(18-7-4-5-8-20(18)30-3)26(25(29)24(21)28)17-12-10-16(11-13-17)19-9-6-14-31-19/h4-15,21-22H,1-3H3 NDHLMKVKIRPOHC-UHFFFAOYSA-N 105714 US8575197, I-224 P2X purinoceptor 3 Homo sapiens 73 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105714 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105714&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808361 174008025 ZINC96176578 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224541 COc1ccccc1C1C(C(=O)CC(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccc(C)o1 InChI=1S/C27H27NO5/c1-16(2)15-21(29)24-25(20-7-5-6-8-23(20)32-4)28(27(31)26(24)30)19-12-10-18(11-13-19)22-14-9-17(3)33-22/h5-14,16,24-25H,15H2,1-4H3 OHFWYOWLZCLVNL-UHFFFAOYSA-N 105873 US8575197, I-383 P2X purinoceptor 3 Homo sapiens 36 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105873 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105873&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808508 174008184 ZINC96176735 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224542 CC(C)CC(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1ccc(C)o1)c1ccccc1OCCO InChI=1S/C28H29NO6/c1-17(2)16-22(31)25-26(21-6-4-5-7-24(21)34-15-14-30)29(28(33)27(25)32)20-11-9-19(10-12-20)23-13-8-18(3)35-23/h4-13,17,25-26,30H,14-16H2,1-3H3 AYOWMFKCJUYFKH-UHFFFAOYSA-N 105874 US8575197, I-384 P2X purinoceptor 3 Homo sapiens 19 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105874 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105874&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808509 174008185 ZINC96176736 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224543 COCc1ccccc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc2sc(C)nc2c1 InChI=1S/C24H24N2O4S/c1-13(2)22(27)20-21(17-8-6-5-7-15(17)12-30-4)26(24(29)23(20)28)16-9-10-19-18(11-16)25-14(3)31-19/h5-11,13,20-21H,12H2,1-4H3 DJMKCXKCKZTOAV-UHFFFAOYSA-N 105875 US8575197, I-385 P2X purinoceptor 3 Homo sapiens 227 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105875 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105875&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808510 174008186 ZINC96176737 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224544 COCCOc1ccccc1C1C(C(=O)CC(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1coc(C)n1 InChI=1S/C28H30N2O6/c1-17(2)15-23(31)25-26(21-7-5-6-8-24(21)35-14-13-34-4)30(28(33)27(25)32)20-11-9-19(10-12-20)22-16-36-18(3)29-22/h5-12,16-17,25-26H,13-15H2,1-4H3 QQNISZJEZSGSOP-UHFFFAOYSA-N 105881 US8575197, I-391 P2X purinoceptor 3 Homo sapiens 684 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105881 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105881&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808511 174008192 ZINC96176743 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224545 COCc1ccccc1C1C(C(=O)CC(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1coc(C)n1 InChI=1S/C27H28N2O5/c1-16(2)13-23(30)24-25(21-8-6-5-7-19(21)14-33-4)29(27(32)26(24)31)20-11-9-18(10-12-20)22-15-34-17(3)28-22/h5-12,15-16,24-25H,13-14H2,1-4H3 FVJSDMZRKNWBMA-UHFFFAOYSA-N 105882 US8575197, I-392 P2X purinoceptor 3 Homo sapiens 946 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105882 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105882&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808512 174008193 ZINC96176744 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224546 COCc1ccccc1[C@@H]1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccc(C)s1 InChI=1S/C27H27NO4S/c1-16(2)25(29)23-24(21-8-6-5-7-19(21)15-32-4)28(27(31)26(23)30)20-12-10-18(11-13-20)22-14-9-17(3)33-22/h5-14,16,23-24H,15H2,1-4H3/t23?,24-/m1/s1 BYRMHEMRSOPNRI-XMMISQBUSA-N 105883 US8575197, I-393 P2X purinoceptor 3 Homo sapiens 15 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105883 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105883&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808513 174008194 ZINC96176745 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224547 COCc1ccccc1[C@@H]1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1cccs1 InChI=1S/C26H25NO4S/c1-16(2)24(28)22-23(20-8-5-4-7-18(20)15-31-3)27(26(30)25(22)29)19-12-10-17(11-13-19)21-9-6-14-32-21/h4-14,16,22-23H,15H2,1-3H3/t22?,23-/m1/s1 GGVOWCTWTHVJOQ-OZAIVSQSSA-N 105884 US8575197, I-394 P2X purinoceptor 3 Homo sapiens 11 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105884 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105884&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808514 174008195 ZINC96176746 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224548 COCCOc1ncccc1[C@@H]1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccsc1 InChI=1S/C26H26N2O5S/c1-16(2)23(29)21-22(20-5-4-11-27-25(20)33-13-12-32-3)28(26(31)24(21)30)19-8-6-17(7-9-19)18-10-14-34-15-18/h4-11,14-16,21-22H,12-13H2,1-3H3/t21?,22-/m1/s1 IWWLAXGNKQEFNJ-FOIFJWKZSA-N 105885 US8575197, I-395 P2X purinoceptor 3 Homo sapiens 6 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105885 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105885&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808515 174008196 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224549 CC(C)Oc1ccccc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccc(C)o1 InChI=1S/C28H29NO5/c1-16(2)26(30)24-25(21-8-6-7-9-23(21)33-17(3)4)29(28(32)27(24)31)20-13-11-19(12-14-20)22-15-10-18(5)34-22/h6-17,24-25H,1-5H3 YJUKXUCMZSELFE-UHFFFAOYSA-N 105886 US8575197, I-396 P2X purinoceptor 3 Homo sapiens 7 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105886 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105886&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808516 174008197 ZINC96176747 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224550 CC(C)C(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1ccc(C)o1)c1ccccc1C(=O)N(C)C InChI=1S/C28H28N2O5/c1-16(2)25(31)23-24(20-8-6-7-9-21(20)27(33)29(4)5)30(28(34)26(23)32)19-13-11-18(12-14-19)22-15-10-17(3)35-22/h6-16,23-24H,1-5H3 QMRUQNAGEQMQEW-UHFFFAOYSA-N 105887 US8575197, I-397 P2X purinoceptor 3 Homo sapiens 122 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105887 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105887&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808517 174008198 ZINC96176748 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224551 CC(C)CC(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1ccc(C)o1)c1ccccc1OC(C)C InChI=1S/C29H31NO5/c1-17(2)16-23(31)26-27(22-8-6-7-9-25(22)34-18(3)4)30(29(33)28(26)32)21-13-11-20(12-14-21)24-15-10-19(5)35-24/h6-15,17-18,26-27H,16H2,1-5H3 HMRKWTLXVNNMRN-UHFFFAOYSA-N 105888 US8575197, I-398 P2X purinoceptor 3 Homo sapiens 14 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105888 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105888&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808518 174008199 ZINC96176749 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224552 CC(C)CC(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1ccc(C)o1)c1ccccc1C(=O)N(C)C InChI=1S/C29H30N2O5/c1-17(2)16-23(32)25-26(21-8-6-7-9-22(21)28(34)30(4)5)31(29(35)27(25)33)20-13-11-19(12-14-20)24-15-10-18(3)36-24/h6-15,17,25-26H,16H2,1-5H3 SGLPUJBJAFWJHW-UHFFFAOYSA-N 105889 US8575197, I-399 P2X purinoceptor 3 Homo sapiens 44 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105889 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105889&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808519 174008200 ZINC96176750 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224553 CC(C)Oc1ccccc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccc(C)s1 InChI=1S/C28H29NO4S/c1-16(2)26(30)24-25(21-8-6-7-9-22(21)33-17(3)4)29(28(32)27(24)31)20-13-11-19(12-14-20)23-15-10-18(5)34-23/h6-17,24-25H,1-5H3 ZZVSBVBMKNATDX-UHFFFAOYSA-N 105890 US8575197, I-400 P2X purinoceptor 3 Homo sapiens 22 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105890 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105890&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808520 174008201 ZINC96176751 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224554 CC(C)C(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1ccc(C)s1)c1ccccc1C(=O)N(C)C InChI=1S/C28H28N2O4S/c1-16(2)25(31)23-24(20-8-6-7-9-21(20)27(33)29(4)5)30(28(34)26(23)32)19-13-11-18(12-14-19)22-15-10-17(3)35-22/h6-16,23-24H,1-5H3 IHZDDHUPFPGNLX-UHFFFAOYSA-N 105891 US8575197, I-401 P2X purinoceptor 3 Homo sapiens 79 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105891 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105891&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808521 174008202 ZINC96176752 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224555 CC(C)CC(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1ccc(C)s1)c1ccccc1OC(C)C InChI=1S/C29H31NO4S/c1-17(2)16-23(31)26-27(22-8-6-7-9-24(22)34-18(3)4)30(29(33)28(26)32)21-13-11-20(12-14-21)25-15-10-19(5)35-25/h6-15,17-18,26-27H,16H2,1-5H3 QRAZEXVOQXQOEZ-UHFFFAOYSA-N 105892 US8575197, I-402 P2X purinoceptor 3 Homo sapiens 80 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105892 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105892&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808522 174008203 ZINC96176753 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224556 CC(C)CC(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1csc(C)c1)c1ccccc1C(=O)N(C)C InChI=1S/C29H30N2O4S/c1-17(2)14-24(32)25-26(22-8-6-7-9-23(22)28(34)30(4)5)31(29(35)27(25)33)21-12-10-19(11-13-21)20-15-18(3)36-16-20/h6-13,15-17,25-26H,14H2,1-5H3 TXDPMWWXOKDALZ-UHFFFAOYSA-N 105894 US8575197, I-404 P2X purinoceptor 3 Homo sapiens 71 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105894 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105894&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808523 174008205 ZINC96176755 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224557 CC(C)CC(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1ccsc1)c1ccccc1C(=O)N(C)C InChI=1S/C28H28N2O4S/c1-17(2)15-23(31)24-25(21-7-5-6-8-22(21)27(33)29(3)4)30(28(34)26(24)32)20-11-9-18(10-12-20)19-13-14-35-16-19/h5-14,16-17,24-25H,15H2,1-4H3 KKAQMIVGIKEKPW-UHFFFAOYSA-N 105895 US8575197, I-405 P2X purinoceptor 3 Homo sapiens 31 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105895 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105895&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808524 174008206 ZINC96176756 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224558 CC(C)CC(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1ccc(C)s1)c1ccccc1C(=O)N(C)C InChI=1S/C29H30N2O4S/c1-17(2)16-23(32)25-26(21-8-6-7-9-22(21)28(34)30(4)5)31(29(35)27(25)33)20-13-11-19(12-14-20)24-15-10-18(3)36-24/h6-15,17,25-26H,16H2,1-5H3 KPEGKBZAPGWVBV-UHFFFAOYSA-N 105896 US8575197, I-406 P2X purinoceptor 3 Homo sapiens 29 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105896 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105896&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808525 174008207 ZINC96176757 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224559 CC(C)CC(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1ccoc1)c1ccccc1OC(C)C InChI=1S/C28H29NO5/c1-17(2)15-23(30)25-26(22-7-5-6-8-24(22)34-18(3)4)29(28(32)27(25)31)21-11-9-19(10-12-21)20-13-14-33-16-20/h5-14,16-18,25-26H,15H2,1-4H3 CJHOCOWNJSYCMX-UHFFFAOYSA-N 105898 US8575197, I-408 P2X purinoceptor 3 Homo sapiens 18 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105898 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105898&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808526 174008209 ZINC96176759 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224560 CC(C)C(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1csc(C)c1)c1ccccc1C(=O)N(C)C InChI=1S/C28H28N2O4S/c1-16(2)25(31)23-24(21-8-6-7-9-22(21)27(33)29(4)5)30(28(34)26(23)32)20-12-10-18(11-13-20)19-14-17(3)35-15-19/h6-16,23-24H,1-5H3 BZZFYJGYSGATEG-UHFFFAOYSA-N 105899 US8575197, I-409 P2X purinoceptor 3 Homo sapiens 177 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105899 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105899&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808527 174008210 ZINC96176760 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224561 COCCOc1ccccc1C1C(C(=O)CC(C)C)C(=O)C(=O)N1c1ccc(cc1)C1=NCCS1 InChI=1S/C27H30N2O5S/c1-17(2)16-21(30)23-24(20-6-4-5-7-22(20)34-14-13-33-3)29(27(32)25(23)31)19-10-8-18(9-11-19)26-28-12-15-35-26/h4-11,17,23-24H,12-16H2,1-3H3 OOHZIIPXCQADAM-UHFFFAOYSA-N 105900 US8575197, I-410 P2X purinoceptor 3 Homo sapiens 151 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105900 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105900&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808528 174008211 ZINC96176761 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224562 COc1ccccc1C1C(C(=O)CC(C)C)C(=O)C(=O)N1c1ccc(cc1)C1=NCCS1 InChI=1S/C25H26N2O4S/c1-15(2)14-19(28)21-22(18-6-4-5-7-20(18)31-3)27(25(30)23(21)29)17-10-8-16(9-11-17)24-26-12-13-32-24/h4-11,15,21-22H,12-14H2,1-3H3 CSPPXPIENWGPNS-UHFFFAOYSA-N 105902 US8575197, I-412 P2X purinoceptor 3 Homo sapiens 310 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105902 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105902&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808529 174008213 ZINC96176763 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224563 CC(C)CC(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)C1=NCCS1)c1ccccc1OC(C)C InChI=1S/C27H30N2O4S/c1-16(2)15-21(30)23-24(20-7-5-6-8-22(20)33-17(3)4)29(27(32)25(23)31)19-11-9-18(10-12-19)26-28-13-14-34-26/h5-12,16-17,23-24H,13-15H2,1-4H3 DUACVKBUNMEQDX-UHFFFAOYSA-N 105903 US8575197, I-413 P2X purinoceptor 3 Homo sapiens 42 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105903 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105903&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808530 174008214 ZINC96176764 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224564 COCc1ccccc1C1C(C(=O)CC(C)C)C(=O)C(=O)N1c1ccc(cc1)C1=NCCS1 InChI=1S/C26H28N2O4S/c1-16(2)14-21(29)22-23(20-7-5-4-6-18(20)15-32-3)28(26(31)24(22)30)19-10-8-17(9-11-19)25-27-12-13-33-25/h4-11,16,22-23H,12-15H2,1-3H3 CWLPUGYCZCEVRS-UHFFFAOYSA-N 105904 US8575197, I-414 P2X purinoceptor 3 Homo sapiens 268 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=105904 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=105904&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808531 174008215 ZINC96176765 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224565 CC(C)CC(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1ccc(C)s1)c1cccnc1C(N)=O InChI=1S/C26H25N3O4S/c1-14(2)13-19(30)21-23(18-5-4-12-28-22(18)25(27)32)29(26(33)24(21)31)17-9-7-16(8-10-17)20-11-6-15(3)34-20/h4-12,14,21,23H,13H2,1-3H3,(H2,27,32) RJDBRBVWSBBYEE-UHFFFAOYSA-N 106062 US8575197, I-572 P2X purinoceptor 3 Homo sapiens 171 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106062 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106062&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808679 174008373 ZINC96176923 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224566 CNC(=O)c1ncccc1C1C(C(=O)CC(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccc(C)s1 InChI=1S/C27H27N3O4S/c1-15(2)14-20(31)22-24(19-6-5-13-29-23(19)26(33)28-4)30(27(34)25(22)32)18-10-8-17(9-11-18)21-12-7-16(3)35-21/h5-13,15,22,24H,14H2,1-4H3,(H,28,33) ZYHYOJHMMXGWLA-UHFFFAOYSA-N 106063 US8575197, I-573 P2X purinoceptor 3 Homo sapiens 123 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106063 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106063&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808680 174008374 ZINC96176924 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224567 CC(C)CC(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1ccc(C)s1)c1cccnc1C(=O)N(C)C InChI=1S/C28H29N3O4S/c1-16(2)15-21(32)23-25(20-7-6-14-29-24(20)27(34)30(4)5)31(28(35)26(23)33)19-11-9-18(10-12-19)22-13-8-17(3)36-22/h6-14,16,23,25H,15H2,1-5H3 GXNMAXBBOZAHFC-UHFFFAOYSA-N 106064 US8575197, I-574 P2X purinoceptor 3 Homo sapiens 280 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106064 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106064&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808681 174008375 ZINC96176925 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224568 CCN(C)C(=O)c1ncccc1C1C(C(=O)CC(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccc(C)s1 InChI=1S/C29H31N3O4S/c1-6-31(5)28(35)25-21(8-7-15-30-25)26-24(22(33)16-17(2)3)27(34)29(36)32(26)20-12-10-19(11-13-20)23-14-9-18(4)37-23/h7-15,17,24,26H,6,16H2,1-5H3 DNVBOEMCMAUILF-UHFFFAOYSA-N 106065 US8575197, I-575 P2X purinoceptor 3 Homo sapiens 252 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106065 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106065&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808682 174008376 ZINC96176926 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224569 CC(C)CC(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1ccc(C)s1)c1cccnc1C(=O)NN(C)C InChI=1S/C28H30N4O4S/c1-16(2)15-21(33)23-25(20-7-6-14-29-24(20)27(35)30-31(4)5)32(28(36)26(23)34)19-11-9-18(10-12-19)22-13-8-17(3)37-22/h6-14,16,23,25H,15H2,1-5H3,(H,30,35) UTOUYPOLMQECDA-UHFFFAOYSA-N 106066 US8575197, I-576 P2X purinoceptor 3 Homo sapiens 237 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106066 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106066&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808683 174008377 ZINC96176927 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224570 CC(C)CC(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1ccc(C)s1)c1cccnc1C(=O)NCC#N InChI=1S/C28H26N4O4S/c1-16(2)15-21(33)23-25(20-5-4-13-30-24(20)27(35)31-14-12-29)32(28(36)26(23)34)19-9-7-18(8-10-19)22-11-6-17(3)37-22/h4-11,13,16,23,25H,14-15H2,1-3H3,(H,31,35) DWWZLOMIGAAQKC-UHFFFAOYSA-N 106067 US8575197, I-577 P2X purinoceptor 3 Homo sapiens 47 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106067 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106067&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808684 174008378 ZINC96176928 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224571 CC(C)CC(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1ccc(C)s1)c1cccnc1C(=O)NC(C)C InChI=1S/C29H31N3O4S/c1-16(2)15-22(33)24-26(21-7-6-14-30-25(21)28(35)31-17(3)4)32(29(36)27(24)34)20-11-9-19(10-12-20)23-13-8-18(5)37-23/h6-14,16-17,24,26H,15H2,1-5H3,(H,31,35) VNXPGDTVXDCEJC-UHFFFAOYSA-N 106068 US8575197, I-578 P2X purinoceptor 3 Homo sapiens 386 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106068 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106068&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808685 174008379 ZINC96176929 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224572 CC(C)CC(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1ccc(C)s1)c1cccnc1C(=O)N1CCCC1 InChI=1S/C30H31N3O4S/c1-18(2)17-23(34)25-27(22-7-6-14-31-26(22)29(36)32-15-4-5-16-32)33(30(37)28(25)35)21-11-9-20(10-12-21)24-13-8-19(3)38-24/h6-14,18,25,27H,4-5,15-17H2,1-3H3 DSIOEIMIAFCEJY-UHFFFAOYSA-N 106069 US8575197, I-579 P2X purinoceptor 3 Homo sapiens 429 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106069 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106069&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808686 174008380 ZINC96176930 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224573 COCCNC(=O)c1ncccc1C1C(C(=O)CC(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccc(C)s1 InChI=1S/C29H31N3O5S/c1-17(2)16-22(33)24-26(21-6-5-13-30-25(21)28(35)31-14-15-37-4)32(29(36)27(24)34)20-10-8-19(9-11-20)23-12-7-18(3)38-23/h5-13,17,24,26H,14-16H2,1-4H3,(H,31,35) QCPUGAZMZLLJIV-UHFFFAOYSA-N 106071 US8575197, I-581 P2X purinoceptor 3 Homo sapiens 466 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106071 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106071&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808687 174008382 ZINC96176932 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224574 COCCN(C)C(=O)c1ncccc1C1C(C(=O)CC(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccc(C)s1 InChI=1S/C30H33N3O5S/c1-18(2)17-23(34)25-27(22-7-6-14-31-26(22)29(36)32(4)15-16-38-5)33(30(37)28(25)35)21-11-9-20(10-12-21)24-13-8-19(3)39-24/h6-14,18,25,27H,15-17H2,1-5H3 GROZJVLBVJYTDQ-UHFFFAOYSA-N 106072 US8575197, I-582 P2X purinoceptor 3 Homo sapiens 359 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106072 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106072&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808688 174008383 ZINC96176933 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224575 CC(C)CC(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1ccc(C)s1)c1cccnc1C(=O)NCCN(C)C InChI=1S/C30H34N4O4S/c1-18(2)17-23(35)25-27(22-7-6-14-31-26(22)29(37)32-15-16-33(4)5)34(30(38)28(25)36)21-11-9-20(10-12-21)24-13-8-19(3)39-24/h6-14,18,25,27H,15-17H2,1-5H3,(H,32,37) GJXRYTKFPOAMPJ-UHFFFAOYSA-N 106073 US8575197, I-583 P2X purinoceptor 3 Homo sapiens 1.0e+2 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106073 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106073&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808689 174008384 ZINC96176934 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224576 CC(C)C(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1csc(C)c1)c1ccccc1C(=O)N(C)CCO InChI=1S/C29H30N2O5S/c1-17(2)26(33)24-25(22-7-5-6-8-23(22)28(35)30(4)13-14-32)31(29(36)27(24)34)21-11-9-19(10-12-21)20-15-18(3)37-16-20/h5-12,15-17,24-25,32H,13-14H2,1-4H3 FIFLEAPMPFILEA-UHFFFAOYSA-N 106074 US8575197, I-584 P2X purinoceptor 3 Homo sapiens 167 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106074 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106074&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808690 174008385 ZINC96176935 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224577 CC(C)C(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1ccc(C)o1)c1ccccc1C(=O)N(C)CCO InChI=1S/C29H30N2O6/c1-17(2)26(33)24-25(21-7-5-6-8-22(21)28(35)30(4)15-16-32)31(29(36)27(24)34)20-12-10-19(11-13-20)23-14-9-18(3)37-23/h5-14,17,24-25,32H,15-16H2,1-4H3 OQUMQPXIQFTAHR-UHFFFAOYSA-N 106075 US8575197, I-585 P2X purinoceptor 3 Homo sapiens 157 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106075 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106075&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808691 174008386 ZINC96176936 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224578 COCCN(C)C(=O)c1ccccc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1ccc(C)o1 InChI=1S/C30H32N2O6/c1-18(2)27(33)25-26(22-8-6-7-9-23(22)29(35)31(4)16-17-37-5)32(30(36)28(25)34)21-13-11-20(12-14-21)24-15-10-19(3)38-24/h6-15,18,25-26H,16-17H2,1-5H3 KDLQDYNCCPDIKO-UHFFFAOYSA-N 106076 US8575197, I-586 P2X purinoceptor 3 Homo sapiens 254 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106076 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106076&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808692 174008387 ZINC96176937 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224579 COc1ccccc1C1N(C(=O)C2=C1C(CC(C)(C)C(=O)O2)=NC)c1ccc(cc1)-c1ccsc1 InChI=1S/C28H26N2O4S/c1-28(2)15-21(29-3)23-24(20-7-5-6-8-22(20)33-4)30(26(31)25(23)34-27(28)32)19-11-9-17(10-12-19)18-13-14-35-16-18/h5-14,16,24H,15H2,1-4H3 BYRKIAPEYJZBGQ-UHFFFAOYSA-N 106077 US8575197, I-587 P2X purinoceptor 3 Homo sapiens 374 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106077 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106077&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365518 174008388 ZINC96176938 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224580 CC(C)C(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1ccon1)c1ccccc1OCC1CC1 InChI=1S/C27H26N2O5/c1-16(2)25(30)23-24(20-5-3-4-6-22(20)33-15-17-7-8-17)29(27(32)26(23)31)19-11-9-18(10-12-19)21-13-14-34-28-21/h3-6,9-14,16-17,23-24H,7-8,15H2,1-2H3 KHXDEFIWKFRPTM-UHFFFAOYSA-N 106078 US8575197, I-588 P2X purinoceptor 3 Homo sapiens 29 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106078 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106078&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808693 174008389 ZINC96176939 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224581 CSc1ccc(cc1)N1C(C(C(=O)C(C)C)C(=O)C1=O)c1ccccc1OCC1CC1 InChI=1S/C25H27NO4S/c1-15(2)23(27)21-22(19-6-4-5-7-20(19)30-14-16-8-9-16)26(25(29)24(21)28)17-10-12-18(31-3)13-11-17/h4-7,10-13,15-16,21-22H,8-9,14H2,1-3H3 AMZRNZZRYMVDCM-UHFFFAOYSA-N 106079 US8575197, I-589 P2X purinoceptor 3 Homo sapiens 32 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106079 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106079&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808694 174008390 ZINC96176940 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224582 CC(C)C(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1ccon1)c1ccccc1OCC1CCOCC1 InChI=1S/C29H30N2O6/c1-18(2)27(32)25-26(22-5-3-4-6-24(22)36-17-19-11-14-35-15-12-19)31(29(34)28(25)33)21-9-7-20(8-10-21)23-13-16-37-30-23/h3-10,13,16,18-19,25-26H,11-12,14-15,17H2,1-2H3 ZUMFXVVUSSIQGF-UHFFFAOYSA-N 106080 US8575197, I-590 P2X purinoceptor 3 Homo sapiens 28 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106080 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106080&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808695 174008391 ZINC96176941 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224583 CSc1ccc(cc1)N1C(C(C(=O)C(C)C)C(=O)C1=O)c1ccccc1OCC1CCOCC1 InChI=1S/C27H31NO5S/c1-17(2)25(29)23-24(28(27(31)26(23)30)19-8-10-20(34-3)11-9-19)21-6-4-5-7-22(21)33-16-18-12-14-32-15-13-18/h4-11,17-18,23-24H,12-16H2,1-3H3 ZERQNWDDVWGKSD-UHFFFAOYSA-N 106081 US8575197, I-591 P2X purinoceptor 3 Homo sapiens 31 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106081 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106081&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808696 174008392 ZINC96176942 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224584 CC(C)C(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1noc(C)n1)c1ccccc1CCC(N)=O InChI=1S/C26H26N4O5/c1-14(2)23(32)21-22(19-7-5-4-6-16(19)10-13-20(27)31)30(26(34)24(21)33)18-11-8-17(9-12-18)25-28-15(3)35-29-25/h4-9,11-12,14,21-22H,10,13H2,1-3H3,(H2,27,31) ASNYAZKDZNXGBL-UHFFFAOYSA-N 106082 US8575197, I-592 P2X purinoceptor 3 Homo sapiens 827 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106082 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106082&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808697 174008393 ZINC96176943 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224585 CNC(=O)CCc1ccccc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1noc(C)n1 InChI=1S/C27H28N4O5/c1-15(2)24(33)22-23(20-8-6-5-7-17(20)11-14-21(32)28-4)31(27(35)25(22)34)19-12-9-18(10-13-19)26-29-16(3)36-30-26/h5-10,12-13,15,22-23H,11,14H2,1-4H3,(H,28,32) XMKJWCABDCDRHE-UHFFFAOYSA-N 106083 US8575197, I-593 P2X purinoceptor 3 Homo sapiens 811 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106083 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106083&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808698 174008394 ZINC96176944 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224586 CC(C)NC(=O)CCc1ccccc1C1C(C(=O)C(C)C)C(=O)C(=O)N1c1ccc(cc1)-c1noc(C)n1 InChI=1S/C29H32N4O5/c1-16(2)26(35)24-25(22-9-7-6-8-19(22)12-15-23(34)30-17(3)4)33(29(37)27(24)36)21-13-10-20(11-14-21)28-31-18(5)38-32-28/h6-11,13-14,16-17,24-25H,12,15H2,1-5H3,(H,30,34) QWXOCLXPZNZCFA-UHFFFAOYSA-N 106084 US8575197, I-594 P2X purinoceptor 3 Homo sapiens 715 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106084 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106084&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808699 174008395 ZINC96176945 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224587 CC(C)C(=O)C1C(N(C(=O)C1=O)c1ccc(cc1)-c1csc(C)c1)c1ccccc1N1CCCC1=O InChI=1S/C29H28N2O4S/c1-17(2)27(33)25-26(22-7-4-5-8-23(22)30-14-6-9-24(30)32)31(29(35)28(25)34)21-12-10-19(11-13-21)20-15-18(3)36-16-20/h4-5,7-8,10-13,15-17,25-26H,6,9,14H2,1-3H3 JTAPFYIQJGFBCZ-UHFFFAOYSA-N 106088 US8575197, I-598 P2X purinoceptor 3 Homo sapiens 785 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106088 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106088&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91808700 174008399 ZINC96176949 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224588 CCCc1ccc(cc1)N1C(c2c(n[nH]c2C(C)(C)C)C1=O)c1ccccc1OC InChI=1S/C25H29N3O2/c1-6-9-16-12-14-17(15-13-16)28-22(18-10-7-8-11-19(18)30-5)20-21(24(28)29)26-27-23(20)25(2,3)4/h7-8,10-15,22H,6,9H2,1-5H3,(H,26,27) FALSDNZMYFWPCC-UHFFFAOYSA-N 106089 US8575197, II-001 P2X purinoceptor 3 Homo sapiens 104 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106089 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106089&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365930 174008400 ZINC96176950 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224589 COc1ccccc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)C)c1ccc(OC(C)C)cc1 InChI=1S/C25H29N3O3/c1-15(2)31-17-13-11-16(12-14-17)28-22(18-9-7-8-10-19(18)30-6)20-21(24(28)29)26-27-23(20)25(3,4)5/h7-15,22H,1-6H3,(H,26,27) KUSZBSACZKSBEU-UHFFFAOYSA-N 106090 US8575197, II-002 P2X purinoceptor 3 Homo sapiens 217 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106090 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106090&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365943 174008401 ZINC96176951 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224590 COc1ccccc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)C)c1ccc(cc1)C(C)(C)C InChI=1S/C26H31N3O2/c1-25(2,3)16-12-14-17(15-13-16)29-22(18-10-8-9-11-19(18)31-7)20-21(24(29)30)27-28-23(20)26(4,5)6/h8-15,22H,1-7H3,(H,27,28) JXQLSSXSIXTLMR-UHFFFAOYSA-N 106091 US8575197, II-003 P2X purinoceptor 3 Homo sapiens 140 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106091 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106091&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365917 174008402 ZINC96176952 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224591 COc1ccccc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)C)c1ccc(SC(F)(F)F)cc1 InChI=1S/C23H22F3N3O2S/c1-22(2,3)20-17-18(27-28-20)21(30)29(19(17)15-7-5-6-8-16(15)31-4)13-9-11-14(12-10-13)32-23(24,25)26/h5-12,19H,1-4H3,(H,27,28) VIBFDGBSFLBUNC-UHFFFAOYSA-N 106092 US8575197, II-004 P2X purinoceptor 3 Homo sapiens 378 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106092 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106092&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365866 174008403 ZINC96176953 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224592 CC(C)(C)c1[nH]nc2C(=O)N(C(c12)c1cccc2OCOc12)c1ccc(cc1)-c1ccon1 InChI=1S/C25H22N4O4/c1-25(2,3)23-19-20(26-27-23)24(30)29(15-9-7-14(8-10-15)17-11-12-33-28-17)21(19)16-5-4-6-18-22(16)32-13-31-18/h4-12,21H,13H2,1-3H3,(H,26,27) WGCFRXSUAXISFM-UHFFFAOYSA-N 106094 US8575197, II-006 P2X purinoceptor 3 Homo sapiens 245 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106094 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106094&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365426 174008405 ZINC96176955 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224593 COc1ncccc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)C)c1ccc(SC)cc1 InChI=1S/C22H24N4O2S/c1-22(2,3)19-16-17(24-25-19)21(27)26(13-8-10-14(29-5)11-9-13)18(16)15-7-6-12-23-20(15)28-4/h6-12,18H,1-5H3,(H,24,25) KGBDFGPALQILEO-UHFFFAOYSA-N 106095 US8575197, II-009 P2X purinoceptor 3 Homo sapiens 62 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106095 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106095&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365961 174008406 ZINC96176956 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224594 COc1ccccc1C1N(C(=O)c2[nH]nc(c12)C(C)(C)COC(C)=O)c1ccc(SC)cc1 InChI=1S/C25H27N3O4S/c1-15(29)32-14-25(2,3)23-20-21(26-27-23)24(30)28(16-10-12-17(33-5)13-11-16)22(20)18-8-6-7-9-19(18)31-4/h6-13,22H,14H2,1-5H3,(H,26,27) SQFAVZAQOVRYFZ-UHFFFAOYSA-N 106097 US8575197, II-010 P2X purinoceptor 3 Homo sapiens 134 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106097 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106097&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365844 174008408 ZINC96176958 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224595 COc1ccccc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)CO)c1ccc(SC)cc1 InChI=1S/C23H25N3O3S/c1-23(2,13-27)21-18-19(24-25-21)22(28)26(14-9-11-15(30-4)12-10-14)20(18)16-7-5-6-8-17(16)29-3/h5-12,20,27H,13H2,1-4H3,(H,24,25) HSVWUSCRFDJAKR-UHFFFAOYSA-N 106096 US8575197, II-009 P2X purinoceptor 3 Homo sapiens 54 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106096 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106096&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58366019 174008407 ZINC96176957 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224596 COc1ccccc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)CO)c1ccc(cc1)N(C)C InChI=1S/C24H28N4O3/c1-24(2,14-29)22-19-20(25-26-22)23(30)28(16-12-10-15(11-13-16)27(3)4)21(19)17-8-6-7-9-18(17)31-5/h6-13,21,29H,14H2,1-5H3,(H,25,26) MPZLYTVFEBBXHY-UHFFFAOYSA-N 106098 US8575197, II-011 P2X purinoceptor 3 Homo sapiens 319 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106098 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106098&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365856 174008409 ZINC96176959 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224597 CC(C)(C)c1[nH]nc2C(=O)N(C(c12)c1ccccc1OCCO)c1ccc(cc1)-c1cccs1 InChI=1S/C27H27N3O3S/c1-27(2,3)25-22-23(28-29-25)26(32)30(18-12-10-17(11-13-18)21-9-6-16-34-21)24(22)19-7-4-5-8-20(19)33-15-14-31/h4-13,16,24,31H,14-15H2,1-3H3,(H,28,29) DQHJZOIZGSZQMO-UHFFFAOYSA-N 106099 US8575197, II-012 P2X purinoceptor 3 Homo sapiens 4 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106099 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106099&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58366123 174008410 ZINC96176960 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224598 CSc1ccc(cc1)N1C(c2c(n[nH]c2C(C)(C)C)C1=O)c1ccccc1OCCO InChI=1S/C24H27N3O3S/c1-24(2,3)22-19-20(25-26-22)23(29)27(15-9-11-16(31-4)12-10-15)21(19)17-7-5-6-8-18(17)30-14-13-28/h5-12,21,28H,13-14H2,1-4H3,(H,25,26) MMXZDNSHYURFMJ-UHFFFAOYSA-N 106100 US8575197, II-013 P2X purinoceptor 3 Homo sapiens 19 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106100 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106100&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365466 174008411 ZINC96176961 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224599 CC(C)(C)c1[nH]nc2C(=O)N(C(c12)c1ccccc1OCCO)c1ccc(cc1)-c1nccs1 InChI=1S/C26H26N4O3S/c1-26(2,3)23-20-21(28-29-23)25(32)30(17-10-8-16(9-11-17)24-27-12-15-34-24)22(20)18-6-4-5-7-19(18)33-14-13-31/h4-12,15,22,31H,13-14H2,1-3H3,(H,28,29) VAQTVLCOUFGXRC-UHFFFAOYSA-N 106101 US8575197, II-014 P2X purinoceptor 3 Homo sapiens 17 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106101 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106101&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365915 174008412 ZINC96176962 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224600 Cc1cc(on1)-c1ccc(cc1)N1C(c2c(n[nH]c2C(C)(C)C)C1=O)c1ccccc1OCCO InChI=1S/C27H28N4O4/c1-16-15-21(35-30-16)17-9-11-18(12-10-17)31-24(19-7-5-6-8-20(19)34-14-13-32)22-23(26(31)33)28-29-25(22)27(2,3)4/h5-12,15,24,32H,13-14H2,1-4H3,(H,28,29) ISTBTHZTOYXVNX-UHFFFAOYSA-N 106102 US8575197, II-015 P2X purinoceptor 3 Homo sapiens 87 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106102 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106102&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365722 174008413 ZINC96176963 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224601 Cc1noc(n1)-c1ccc(cc1)N1C(c2c(n[nH]c2C(C)(C)C)C1=O)c1ccccc1OCCO InChI=1S/C26H27N5O4/c1-15-27-24(35-30-15)16-9-11-17(12-10-16)31-22(18-7-5-6-8-19(18)34-14-13-32)20-21(25(31)33)28-29-23(20)26(2,3)4/h5-12,22,32H,13-14H2,1-4H3,(H,28,29) ZTPMMFVRWCDEJP-UHFFFAOYSA-N 106103 US8575197, II-016 P2X purinoceptor 3 Homo sapiens 158 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106103 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106103&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365840 174008414 ZINC96176964 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224602 Cc1nc(no1)-c1ccc(cc1)N1C(c2c(n[nH]c2C(C)(C)C)C1=O)c1ccccc1OCCO InChI=1S/C26H27N5O4/c1-15-27-24(30-35-15)16-9-11-17(12-10-16)31-22(18-7-5-6-8-19(18)34-14-13-32)20-21(25(31)33)28-29-23(20)26(2,3)4/h5-12,22,32H,13-14H2,1-4H3,(H,28,29) AFIVPBIBCPBTTF-UHFFFAOYSA-N 106104 US8575197, II-017 P2X purinoceptor 3 Homo sapiens 54 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106104 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106104&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365980 174008415 ZINC96176965 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224603 COCCOc1ccccc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)C)c1ccc(cc1)-c1ccon1 InChI=1S/C27H28N4O4/c1-27(2,3)25-22-23(28-29-25)26(32)31(18-11-9-17(10-12-18)20-13-14-35-30-20)24(22)19-7-5-6-8-21(19)34-16-15-33-4/h5-14,24H,15-16H2,1-4H3,(H,28,29) SXDOFXNNQAYGLT-UHFFFAOYSA-N 106105 US8575197, II-018 P2X purinoceptor 3 Homo sapiens 22 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106105 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106105&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365422 174008416 ZINC96176966 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224604 CC(C)Oc1ccccc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)C)c1ccc(cc1)-c1ccon1 InChI=1S/C27H28N4O3/c1-16(2)34-21-9-7-6-8-19(21)24-22-23(28-29-25(22)27(3,4)5)26(32)31(24)18-12-10-17(11-13-18)20-14-15-33-30-20/h6-16,24H,1-5H3,(H,28,29) KSPMIQNTDYYZMP-UHFFFAOYSA-N 106106 US8575197, II-019 P2X purinoceptor 3 Homo sapiens 21 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106106 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106106&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365901 174008417 ZINC96176967 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224605 COC(=O)COc1ccccc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)C)c1ccc(cc1)-c1ccsc1 InChI=1S/C28H27N3O4S/c1-28(2,3)26-23-24(29-30-26)27(33)31(19-11-9-17(10-12-19)18-13-14-36-16-18)25(23)20-7-5-6-8-21(20)35-15-22(32)34-4/h5-14,16,25H,15H2,1-4H3,(H,29,30) RUOLDQNVJUXQKG-UHFFFAOYSA-N 106107 US8575197, II-020 P2X purinoceptor 3 Homo sapiens 8 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106107 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106107&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365850 174008418 ZINC96176968 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224606 COC(=O)COc1ccccc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)C)c1ccc(cc1)-c1cccs1 InChI=1S/C28H27N3O4S/c1-28(2,3)26-23-24(29-30-26)27(33)31(18-13-11-17(12-14-18)21-10-7-15-36-21)25(23)19-8-5-6-9-20(19)35-16-22(32)34-4/h5-15,25H,16H2,1-4H3,(H,29,30) FHQBEGHLQHWYMW-UHFFFAOYSA-N 106108 US8575197, II-021 P2X purinoceptor 3 Homo sapiens 9 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106108 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106108&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365486 174008419 ZINC96176969 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224607 CC(C)(C)c1[nH]nc2C(=O)N(C(c12)c1ccccc1OCC(O)=O)c1ccc(cc1)-c1cccs1 InChI=1S/C27H25N3O4S/c1-27(2,3)25-22-23(28-29-25)26(33)30(17-12-10-16(11-13-17)20-9-6-14-35-20)24(22)18-7-4-5-8-19(18)34-15-21(31)32/h4-14,24H,15H2,1-3H3,(H,28,29)(H,31,32) YCUUITOZSGLOPG-UHFFFAOYSA-N 106109 US8575197, II-022 P2X purinoceptor 3 Homo sapiens 4 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106109 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106109&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365960 174008420 ZINC96176970 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224608 CC(C)(C)c1[nH]nc2C(=O)N(C(c12)c1ccccc1OCC(O)=O)c1ccc(cc1)-c1ccsc1 InChI=1S/C27H25N3O4S/c1-27(2,3)25-22-23(28-29-25)26(33)30(18-10-8-16(9-11-18)17-12-13-35-15-17)24(22)19-6-4-5-7-20(19)34-14-21(31)32/h4-13,15,24H,14H2,1-3H3,(H,28,29)(H,31,32) NVUIDYCJJZAUMQ-UHFFFAOYSA-N 106110 US8575197, II-023 P2X purinoceptor 3 Homo sapiens 4 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106110 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106110&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365512 174008421 ZINC96176971 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224609 COCCOc1ccccc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)C)c1ccc(cc1)-c1nc(C)no1 InChI=1S/C27H29N5O4/c1-16-28-25(36-31-16)17-10-12-18(13-11-17)32-23(19-8-6-7-9-20(19)35-15-14-34-5)21-22(26(32)33)29-30-24(21)27(2,3)4/h6-13,23H,14-15H2,1-5H3,(H,29,30) FQFHIZLVKBLDRY-UHFFFAOYSA-N 106111 US8575197, II-024 P2X purinoceptor 3 Homo sapiens 62 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106111 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106111&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365579 174008422 ZINC96176972 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224610 COCCOc1ccccc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)C)c1ccc(cc1)-c1noc(C)n1 InChI=1S/C27H29N5O4/c1-16-28-25(31-36-16)17-10-12-18(13-11-17)32-23(19-8-6-7-9-20(19)35-15-14-34-5)21-22(26(32)33)29-30-24(21)27(2,3)4/h6-13,23H,14-15H2,1-5H3,(H,29,30) QOHPXKWSSCLZNB-UHFFFAOYSA-N 106112 US8575197, II-025 P2X purinoceptor 3 Homo sapiens 15 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106112 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106112&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58366059 174008423 ZINC96176973 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224611 COCCOc1ccccc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)C)c1ccc(SC)cc1 InChI=1S/C25H29N3O3S/c1-25(2,3)23-20-21(26-27-23)24(29)28(16-10-12-17(32-5)13-11-16)22(20)18-8-6-7-9-19(18)31-15-14-30-4/h6-13,22H,14-15H2,1-5H3,(H,26,27) ANWIVJUHTPJFEF-UHFFFAOYSA-N 106113 US8575197, II-026 P2X purinoceptor 3 Homo sapiens 23 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106113 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106113&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365543 174008424 ZINC96176974 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224612 COCCOc1ccccc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)C)c1ccc(cc1)-c1ccco1 InChI=1S/C28H29N3O4/c1-28(2,3)26-23-24(29-30-26)27(32)31(19-13-11-18(12-14-19)21-10-7-15-34-21)25(23)20-8-5-6-9-22(20)35-17-16-33-4/h5-15,25H,16-17H2,1-4H3,(H,29,30) IXJRQALXBCFYOA-UHFFFAOYSA-N 106114 US8575197, II-027 P2X purinoceptor 3 Homo sapiens 8 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106114 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106114&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365349 174008425 ZINC96176975 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224613 COC(=O)COc1ccccc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)C)c1ccc(cc1)-c1ccon1 InChI=1S/C27H26N4O5/c1-27(2,3)25-22-23(28-29-25)26(33)31(17-11-9-16(10-12-17)19-13-14-36-30-19)24(22)18-7-5-6-8-20(18)35-15-21(32)34-4/h5-14,24H,15H2,1-4H3,(H,28,29) UOXOKSKEZHXFDR-UHFFFAOYSA-N 106115 US8575197, II-028 P2X purinoceptor 3 Homo sapiens 14 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106115 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106115&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58366072 174008426 ZINC96176976 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224614 CC(C)(C)c1[nH]nc2C(=O)N(C(c12)c1ccccc1OCC(O)=O)c1ccc(cc1)-c1ccon1 InChI=1S/C26H24N4O5/c1-26(2,3)24-21-22(27-28-24)25(33)30(16-10-8-15(9-11-16)18-12-13-35-29-18)23(21)17-6-4-5-7-19(17)34-14-20(31)32/h4-13,23H,14H2,1-3H3,(H,27,28)(H,31,32) RPPBNXPYURTLBF-UHFFFAOYSA-N 106116 US8575197, II-029 P2X purinoceptor 3 Homo sapiens 90 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106116 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106116&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365453 174008427 ZINC96176977 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224615 CN(C)CCOc1ccccc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)C)c1ccc(cc1)-c1ccon1 InChI=1S/C28H31N5O3/c1-28(2,3)26-23-24(29-30-26)27(34)33(19-12-10-18(11-13-19)21-14-16-36-31-21)25(23)20-8-6-7-9-22(20)35-17-15-32(4)5/h6-14,16,25H,15,17H2,1-5H3,(H,29,30) AOODNRAQGKZQCH-UHFFFAOYSA-N 106117 US8575197, II-030 P2X purinoceptor 3 Homo sapiens 128 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106117 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106117&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365592 174008428 ZINC96176978 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224616 CN(C)CCOc1ccccc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)C)c1ccc(cc1)-c1ccsc1 InChI=1S/C29H32N4O2S/c1-29(2,3)27-24-25(30-31-27)28(34)33(21-12-10-19(11-13-21)20-14-17-36-18-20)26(24)22-8-6-7-9-23(22)35-16-15-32(4)5/h6-14,17-18,26H,15-16H2,1-5H3,(H,30,31) PKNHUPGZFBLNGU-UHFFFAOYSA-N 106118 US8575197, II-031 P2X purinoceptor 3 Homo sapiens 18 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106118 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106118&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58366046 174008429 ZINC96176979 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224617 COCCOc1ncccc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)C)c1ccc(cc1)-c1ccsc1 InChI=1S/C27H28N4O3S/c1-27(2,3)24-21-22(29-30-24)26(32)31(19-9-7-17(8-10-19)18-11-15-35-16-18)23(21)20-6-5-12-28-25(20)34-14-13-33-4/h5-12,15-16,23H,13-14H2,1-4H3,(H,29,30) RFXZHGWUTCELJF-UHFFFAOYSA-N 106119 US8575197, II-032 P2X purinoceptor 3 Homo sapiens 6 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106119 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106119&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365938 174008430 ZINC96176980 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224618 COCCOc1ncccc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)C)c1ccc(cc1)-c1ccon1 InChI=1S/C26H27N5O4/c1-26(2,3)23-20-21(28-29-23)25(32)31(17-9-7-16(8-10-17)19-11-13-35-30-19)22(20)18-6-5-12-27-24(18)34-15-14-33-4/h5-13,22H,14-15H2,1-4H3,(H,28,29) KVYQZIAMRWHCNO-UHFFFAOYSA-N 106120 US8575197, II-033 P2X purinoceptor 3 Homo sapiens 117 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106120 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106120&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365462 174008431 ZINC96176981 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224619 COCCOc1ncccc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)C)c1ccc(SC)cc1 InChI=1S/C24H28N4O3S/c1-24(2,3)21-18-19(26-27-21)23(29)28(15-8-10-16(32-5)11-9-15)20(18)17-7-6-12-25-22(17)31-14-13-30-4/h6-12,20H,13-14H2,1-5H3,(H,26,27) CHBZTRURSBWCFA-UHFFFAOYSA-N 106121 US8575197, II-034 P2X purinoceptor 3 Homo sapiens 46 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106121 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106121&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365996 174008432 ZINC96177042 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224620 COCCOc1ncccc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)C)c1ccc(cc1)-c1cccs1 InChI=1S/C27H28N4O3S/c1-27(2,3)24-21-22(29-30-24)26(32)31(18-11-9-17(10-12-18)20-8-6-16-35-20)23(21)19-7-5-13-28-25(19)34-15-14-33-4/h5-13,16,23H,14-15H2,1-4H3,(H,29,30) IGNFJDNVGAINND-UHFFFAOYSA-N 106122 US8575197, II-035 P2X purinoceptor 3 Homo sapiens 6 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106122 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106122&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365370 174008433 ZINC96177043 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224621 CC(C)(C)c1[nH]nc2C(=O)N(C(c12)c1cccnc1OCCO)c1ccc(cc1)-c1ccon1 InChI=1S/C25H25N5O4/c1-25(2,3)22-19-20(27-28-22)24(32)30(16-8-6-15(7-9-16)18-10-13-34-29-18)21(19)17-5-4-11-26-23(17)33-14-12-31/h4-11,13,21,31H,12,14H2,1-3H3,(H,27,28) XFZGLEOUXGDKAH-UHFFFAOYSA-N 106123 US8575197, II-036 P2X purinoceptor 3 Homo sapiens 231 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106123 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106123&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365567 174008434 ZINC96177044 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224622 COCCOc1ncccc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)C)c1ccc(cc1)-c1ccco1 InChI=1S/C27H28N4O4/c1-27(2,3)24-21-22(29-30-24)26(32)31(18-11-9-17(10-12-18)20-8-6-14-34-20)23(21)19-7-5-13-28-25(19)35-16-15-33-4/h5-14,23H,15-16H2,1-4H3,(H,29,30) MDYOQZJPINRNRF-UHFFFAOYSA-N 106124 US8575197, II-037 P2X purinoceptor 3 Homo sapiens 8 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106124 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106124&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365981 174008435 ZINC96177045 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224623 COCCOc1ncccc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)C)c1ccc(cc1)-c1ccoc1 InChI=1S/C27H28N4O4/c1-27(2,3)24-21-22(29-30-24)26(32)31(19-9-7-17(8-10-19)18-11-13-34-16-18)23(21)20-6-5-12-28-25(20)35-15-14-33-4/h5-13,16,23H,14-15H2,1-4H3,(H,29,30) FDOYZEALWJTEFT-UHFFFAOYSA-N 106125 US8575197, II-038 P2X purinoceptor 3 Homo sapiens 14 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106125 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106125&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365372 174008436 ZINC96177046 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224624 CC(C)(C)c1[nH]nc2C(=O)N(C(c12)c1cccnc1OCCO)c1ccc(cc1)-c1ccsc1 InChI=1S/C26H26N4O3S/c1-26(2,3)23-20-21(28-29-23)25(32)30(18-8-6-16(7-9-18)17-10-14-34-15-17)22(20)19-5-4-11-27-24(19)33-13-12-31/h4-11,14-15,22,31H,12-13H2,1-3H3,(H,28,29) ZOYLDVUFRKUGDA-UHFFFAOYSA-N 106126 US8575197, II-039 P2X purinoceptor 3 Homo sapiens 5 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106126 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106126&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365795 174008437 ZINC96177047 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224625 CSc1ccc(cc1)N1C(c2c(n[nH]c2C(C)(C)C)C1=O)c1cccnc1OCCO InChI=1S/C23H26N4O3S/c1-23(2,3)20-17-18(25-26-20)22(29)27(14-7-9-15(31-4)10-8-14)19(17)16-6-5-11-24-21(16)30-13-12-28/h5-11,19,28H,12-13H2,1-4H3,(H,25,26) DFXLELIWAPYXSN-UHFFFAOYSA-N 106127 US8575197, II-070 P2X purinoceptor 3 Homo sapiens 70 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106127 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106127&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58366057 174008438 ZINC96177048 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224626 CC(C)(C)c1[nH]nc2C(=O)N(C(c12)c1cccnc1OCCO)c1ccc(cc1)-c1ccoc1 InChI=1S/C26H26N4O4/c1-26(2,3)23-20-21(28-29-23)25(32)30(18-8-6-16(7-9-18)17-10-13-33-15-17)22(20)19-5-4-11-27-24(19)34-14-12-31/h4-11,13,15,22,31H,12,14H2,1-3H3,(H,28,29) YYBCKQIFBIXSHM-UHFFFAOYSA-N 106128 US8575197, II-041 P2X purinoceptor 3 Homo sapiens 27 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106128 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106128&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365382 174008439 ZINC96177049 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224627 CC(C)(C)c1[nH]nc2C(=O)N(C(c12)c1cccnc1OCCO)c1ccc(cc1)-c1cccs1 InChI=1S/C26H26N4O3S/c1-26(2,3)23-20-21(28-29-23)25(32)30(17-10-8-16(9-11-17)19-7-5-15-34-19)22(20)18-6-4-12-27-24(18)33-14-13-31/h4-12,15,22,31H,13-14H2,1-3H3,(H,28,29) BUPBOFCIXFNJHI-UHFFFAOYSA-N 106129 US8575197, II-042 P2X purinoceptor 3 Homo sapiens 10 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106129 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106129&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365947 174008440 ZINC96177050 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224628 CC(C)(C)c1[nH]nc2C(=O)N(C(c12)c1cccnc1OCCO)c1ccc(cc1)-c1ccco1 InChI=1S/C26H26N4O4/c1-26(2,3)23-20-21(28-29-23)25(32)30(17-10-8-16(9-11-17)19-7-5-14-33-19)22(20)18-6-4-12-27-24(18)34-15-13-31/h4-12,14,22,31H,13,15H2,1-3H3,(H,28,29) AWAIMBFESXPWIU-UHFFFAOYSA-N 106130 US8575197, II-043 P2X purinoceptor 3 Homo sapiens 17 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106130 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106130&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365869 174008441 ZINC96177051 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224629 CC(C)c1[nH]nc2C(=O)N(C(c12)c1cccnc1OCCO)c1ccc(cc1)-c1ccon1 InChI=1S/C24H23N5O4/c1-14(2)20-19-21(27-26-20)24(31)29(16-7-5-15(6-8-16)18-9-12-33-28-18)22(19)17-4-3-10-25-23(17)32-13-11-30/h3-10,12,14,22,30H,11,13H2,1-2H3,(H,26,27) LBTWUUYWXYVXLJ-UHFFFAOYSA-N 106131 US8575197, II-044 P2X purinoceptor 3 Homo sapiens 582 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106131 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106131&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365514 174008442 ZINC96177052 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224630 CC(C)c1[nH]nc2C(=O)N(C(c12)c1cccnc1OCCO)c1ccc(cc1)-c1ccsc1 InChI=1S/C25H24N4O3S/c1-15(2)21-20-22(28-27-21)25(31)29(18-7-5-16(6-8-18)17-9-13-33-14-17)23(20)19-4-3-10-26-24(19)32-12-11-30/h3-10,13-15,23,30H,11-12H2,1-2H3,(H,27,28) CHIGAIXOKHDICR-UHFFFAOYSA-N 106132 US8575197, II-045 P2X purinoceptor 3 Homo sapiens 16 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106132 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106132&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365357 174008443 ZINC96177053 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224631 CC(C)c1[nH]nc2C(=O)N(C(c12)c1cccnc1OCCO)c1ccc(cc1)-c1noc(C)n1 InChI=1S/C24H24N6O4/c1-13(2)19-18-20(28-27-19)24(32)30(21(18)17-5-4-10-25-23(17)33-12-11-31)16-8-6-15(7-9-16)22-26-14(3)34-29-22/h4-10,13,21,31H,11-12H2,1-3H3,(H,27,28) XFPBYLPQTDYFHA-UHFFFAOYSA-N 106133 US8575197, II-046 P2X purinoceptor 3 Homo sapiens 861 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106133 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106133&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365810 174008444 ZINC96177054 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224632 CC(C)c1[nH]nc2C(=O)N(C(c12)c1ccccc1OCC(O)=O)c1ccc(cc1)-c1ccsc1 InChI=1S/C26H23N3O4S/c1-15(2)23-22-24(28-27-23)26(32)29(18-9-7-16(8-10-18)17-11-12-34-14-17)25(22)19-5-3-4-6-20(19)33-13-21(30)31/h3-12,14-15,25H,13H2,1-2H3,(H,27,28)(H,30,31) OTLSKRUOCPZQCN-UHFFFAOYSA-N 106134 US8575197, II-047 P2X purinoceptor 3 Homo sapiens 11 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106134 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106134&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365490 174008445 ZINC96177055 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224633 COc1ncccc1C1N(C(=O)c2n[nH]c(C(C)C)c12)c1ccc(cc1)-c1ccsc1 InChI=1S/C24H22N4O2S/c1-14(2)20-19-21(27-26-20)24(29)28(22(19)18-5-4-11-25-23(18)30-3)17-8-6-15(7-9-17)16-10-12-31-13-16/h4-14,22H,1-3H3,(H,26,27) QDBONWOFRYJWRD-UHFFFAOYSA-N 106135 US8575197, II-048 P2X purinoceptor 3 Homo sapiens 57 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106135 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106135&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365764 174008446 ZINC96177056 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224634 CNC(=O)COc1ccccc1C1N(C(=O)c2n[nH]c(C(C)C)c12)c1ccc(cc1)-c1ccsc1 InChI=1S/C27H26N4O3S/c1-16(2)24-23-25(30-29-24)27(33)31(19-10-8-17(9-11-19)18-12-13-35-15-18)26(23)20-6-4-5-7-21(20)34-14-22(32)28-3/h4-13,15-16,26H,14H2,1-3H3,(H,28,32)(H,29,30) NHJIZRDAMMERMA-UHFFFAOYSA-N 106136 US8575197, II-049 P2X purinoceptor 3 Homo sapiens 11 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106136 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106136&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68275843 174008447 ZINC96177057 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224635 CC(C)c1[nH]nc2C(=O)N(C(c12)c1ccccc1OCC(N)=O)c1ccc(cc1)-c1ccsc1 InChI=1S/C26H24N4O3S/c1-15(2)23-22-24(29-28-23)26(32)30(18-9-7-16(8-10-18)17-11-12-34-14-17)25(22)19-5-3-4-6-20(19)33-13-21(27)31/h3-12,14-15,25H,13H2,1-2H3,(H2,27,31)(H,28,29) ZVHZSKXNLRWBFX-UHFFFAOYSA-N 106137 US8575197, II-050 P2X purinoceptor 3 Homo sapiens 7 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106137 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106137&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365510 174008448 ZINC96177058 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224636 CC(C)c1[nH]nc2C(=O)N(C(c12)c1ccccc1NS(C)(=O)=O)c1ccc(cc1)-c1ccsc1 InChI=1S/C25H24N4O3S2/c1-15(2)22-21-23(27-26-22)25(30)29(18-10-8-16(9-11-18)17-12-13-33-14-17)24(21)19-6-4-5-7-20(19)28-34(3,31)32/h4-15,24,28H,1-3H3,(H,26,27) YJRUZNCQTSGJNQ-UHFFFAOYSA-N 106175 US8575197, II-088 P2X purinoceptor 3 Homo sapiens 4 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106175 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106175&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365779 174008486 ZINC96177096 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224637 CC(C)c1[nH]nc2C(=O)N(C(c12)c1ccccc1C(O)=O)c1ccc(cc1)-c1ccsc1 InChI=1S/C25H21N3O3S/c1-14(2)21-20-22(27-26-21)24(29)28(23(20)18-5-3-4-6-19(18)25(30)31)17-9-7-15(8-10-17)16-11-12-32-13-16/h3-14,23H,1-2H3,(H,26,27)(H,30,31) YRJSKMMHUPVTKA-UHFFFAOYSA-N 106176 US8575197, II-089 P2X purinoceptor 3 Homo sapiens 107 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106176 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106176&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365314 174008487 ZINC96177097 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224638 CC(C)c1[nH]nc2C(=O)N(C(c12)c1ccccc1C(N)=O)c1ccc(cc1)-c1ccsc1 InChI=1S/C25H22N4O2S/c1-14(2)21-20-22(28-27-21)25(31)29(23(20)18-5-3-4-6-19(18)24(26)30)17-9-7-15(8-10-17)16-11-12-32-13-16/h3-14,23H,1-2H3,(H2,26,30)(H,27,28) DSQQPWKIIKFGHE-UHFFFAOYSA-N 106177 US8575197, II-090 P2X purinoceptor 3 Homo sapiens 2 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106177 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106177&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58366016 174008488 ZINC96177098 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224639 CC(C)c1[nH]nc2C(=O)N(C(c12)c1ccccc1C(=O)NCCO)c1ccc(cc1)-c1ccsc1 InChI=1S/C27H26N4O3S/c1-16(2)23-22-24(30-29-23)27(34)31(19-9-7-17(8-10-19)18-11-14-35-15-18)25(22)20-5-3-4-6-21(20)26(33)28-12-13-32/h3-11,14-16,25,32H,12-13H2,1-2H3,(H,28,33)(H,29,30) RCFYYASKAVHZDW-UHFFFAOYSA-N 106178 US8575197, II-091 P2X purinoceptor 3 Homo sapiens 2 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106178 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106178&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365822 174008489 C04080 ZINC96177099 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224640 CNC(=O)c1ccccc1C1N(C(=O)c2n[nH]c(C(C)C)c12)c1ccc(cc1)-c1ccsc1 InChI=1S/C26H24N4O2S/c1-15(2)22-21-23(29-28-22)26(32)30(18-10-8-16(9-11-18)17-12-13-33-14-17)24(21)19-6-4-5-7-20(19)25(31)27-3/h4-15,24H,1-3H3,(H,27,31)(H,28,29) DSCOIBVZANWSKU-UHFFFAOYSA-N 106179 US8575197, II-092 P2X purinoceptor 3 Homo sapiens 2 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106179 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106179&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365249 174008490 ZINC96177100 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224641 CC(C)c1[nH]nc2C(=O)N(C(c12)c1ccccc1C(=O)N(C)C)c1ccc(cc1)-c1ccsc1 InChI=1S/C27H26N4O2S/c1-16(2)23-22-24(29-28-23)27(33)31(19-11-9-17(10-12-19)18-13-14-34-15-18)25(22)20-7-5-6-8-21(20)26(32)30(3)4/h5-16,25H,1-4H3,(H,28,29) ISGGDMRGCDKPJX-UHFFFAOYSA-N 106180 US8575197, II-093 P2X purinoceptor 3 Homo sapiens 2 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106180 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106180&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365482 174008491 ZINC96177101 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224642 CC(C)c1[nH]nc2C(=O)N(C(c12)c1ccccc1CC(O)=O)c1ccc(cc1)-c1ccsc1 InChI=1S/C26H23N3O3S/c1-15(2)23-22-24(28-27-23)26(32)29(19-9-7-16(8-10-19)18-11-12-33-14-18)25(22)20-6-4-3-5-17(20)13-21(30)31/h3-12,14-15,25H,13H2,1-2H3,(H,27,28)(H,30,31) XVJYEHITWWUQQF-UHFFFAOYSA-N 106181 US8575197, II-094 P2X purinoceptor 3 Homo sapiens 65 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106181 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106181&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365425 174008492 ZINC96177102 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224643 COC(=O)Nc1ccccc1C1N(C(=O)c2n[nH]c(C(C)C)c12)c1ccc(cc1)-c1ccsc1 InChI=1S/C26H24N4O3S/c1-15(2)22-21-23(29-28-22)25(31)30(18-10-8-16(9-11-18)17-12-13-34-14-17)24(21)19-6-4-5-7-20(19)27-26(32)33-3/h4-15,24H,1-3H3,(H,27,32)(H,28,29) YGTCAQPCCOMLKZ-UHFFFAOYSA-N 106182 US8575197, II-095 P2X purinoceptor 3 Homo sapiens 12 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106182 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106182&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365967 174008493 ZINC96177103 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224644 COc1ccccc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)C)c1ccc(cc1)C(F)(F)F InChI=1S/C23H22F3N3O2/c1-22(2,3)20-17-18(27-28-20)21(30)29(14-11-9-13(10-12-14)23(24,25)26)19(17)15-7-5-6-8-16(15)31-4/h5-12,19H,1-4H3,(H,27,28) VKSJTQBDRNQZMX-UHFFFAOYSA-N 106183 US8575197, II-096 P2X purinoceptor 3 Homo sapiens 223 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106183 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106183&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68276954 174008494 ZINC96177104 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224645 COc1ccccc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)C)c1ccc(OC(F)(F)F)cc1 InChI=1S/C23H22F3N3O3/c1-22(2,3)20-17-18(27-28-20)21(30)29(19(17)15-7-5-6-8-16(15)31-4)13-9-11-14(12-10-13)32-23(24,25)26/h5-12,19H,1-4H3,(H,27,28) VFOVBHAOXBOJFO-UHFFFAOYSA-N 106184 US8575197, II-097 P2X purinoceptor 3 Homo sapiens 358 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106184 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106184&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68275907 174008495 ZINC96177105 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224646 COc1ccc(cc1)N1C(c2c(n[nH]c2C(C)(C)C)C1=O)c1ccccc1OC InChI=1S/C23H25N3O3/c1-23(2,3)21-18-19(24-25-21)22(27)26(14-10-12-15(28-4)13-11-14)20(18)16-8-6-7-9-17(16)29-5/h6-13,20H,1-5H3,(H,24,25) KMBGLBYJMAKWHP-UHFFFAOYSA-N 106185 US8575197, II-098 P2X purinoceptor 3 Homo sapiens 761 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106185 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106185&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68275840 174008496 ZINC96177106 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224647 CSc1ccccc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)C)c1ccc(cc1)-c1ccon1 InChI=1S/C25H24N4O2S/c1-25(2,3)23-20-21(26-27-23)24(30)29(22(20)17-7-5-6-8-19(17)32-4)16-11-9-15(10-12-16)18-13-14-31-28-18/h5-14,22H,1-4H3,(H,26,27) YJJCGORFWUJNGD-UHFFFAOYSA-N 106186 US8575197, II-099 P2X purinoceptor 3 Homo sapiens 46 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106186 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106186&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365984 174008497 ZINC96177107 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224648 CC(C)(C)c1[nH]nc2C(=O)N(C(c12)c1ccccc1OCCO)c1ccc(cc1)-c1ccon1 InChI=1S/C26H26N4O4/c1-26(2,3)24-21-22(27-28-24)25(32)30(17-10-8-16(9-11-17)19-12-14-34-29-19)23(21)18-6-4-5-7-20(18)33-15-13-31/h4-12,14,23,31H,13,15H2,1-3H3,(H,27,28) KULIBONXHNHSRK-UHFFFAOYSA-N 106187 US8575197, II-100 P2X purinoceptor 3 Homo sapiens 31 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106187 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106187&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365447 174008498 ZINC96177108 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224649 CCOc1ccccc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)C)c1ccc(cc1)-c1ccon1 InChI=1S/C26H26N4O3/c1-5-32-20-9-7-6-8-18(20)23-21-22(27-28-24(21)26(2,3)4)25(31)30(23)17-12-10-16(11-13-17)19-14-15-33-29-19/h6-15,23H,5H2,1-4H3,(H,27,28) UFOSBJIKHIBKKU-UHFFFAOYSA-N 106188 US8575197, II-101 P2X purinoceptor 3 Homo sapiens 27 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106188 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106188&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365290 174008499 ZINC96177109 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224650 CC(C)(C)c1[nH]nc2C(=O)N(C(c12)c1ccccc1OC(F)F)c1ccc(cc1)-c1ccon1 InChI=1S/C25H22F2N4O3/c1-25(2,3)22-19-20(28-29-22)23(32)31(15-10-8-14(9-11-15)17-12-13-33-30-17)21(19)16-6-4-5-7-18(16)34-24(26)27/h4-13,21,24H,1-3H3,(H,28,29) GQPLVHZLHUCXTB-UHFFFAOYSA-N 106189 US8575197, II-102 P2X purinoceptor 3 Homo sapiens 76 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106189 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106189&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365492 174008500 ZINC96177110 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224651 CC(C)(C)c1[nH]nc2C(=O)N(C(c12)c1ccccc1OCCO)c1ccc(cc1)-c1ccsc1 InChI=1S/C27H27N3O3S/c1-27(2,3)25-22-23(28-29-25)26(32)30(19-10-8-17(9-11-19)18-12-15-34-16-18)24(22)20-6-4-5-7-21(20)33-14-13-31/h4-12,15-16,24,31H,13-14H2,1-3H3,(H,28,29) CCSOXNWHQHQFNO-UHFFFAOYSA-N 106191 US8575197, II-104 P2X purinoceptor 3 Homo sapiens 3 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106191 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106191&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365493 174008502 ZINC96177112 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224652 CC(C)(C)c1[nH]nc2C(=O)N(C(c12)c1ccccc1OCCO)c1ccc(cc1)-c1ccco1 InChI=1S/C27H27N3O4/c1-27(2,3)25-22-23(28-29-25)26(32)30(18-12-10-17(11-13-18)20-9-6-15-33-20)24(22)19-7-4-5-8-21(19)34-16-14-31/h4-13,15,24,31H,14,16H2,1-3H3,(H,28,29) BUURJHHBTKPWAL-UHFFFAOYSA-N 106192 US8575197, II-105 P2X purinoceptor 3 Homo sapiens 13 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106192 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106192&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58366069 174008503 ZINC96177113 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224653 CCc1ccccc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)C)c1ccc(cc1)-c1ccon1 InChI=1S/C26H26N4O2/c1-5-16-8-6-7-9-19(16)23-21-22(27-28-24(21)26(2,3)4)25(31)30(23)18-12-10-17(11-13-18)20-14-15-32-29-20/h6-15,23H,5H2,1-4H3,(H,27,28) WTWTVBWYWPXEPN-UHFFFAOYSA-N 106193 US8575197, II-106 P2X purinoceptor 3 Homo sapiens 226 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106193 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106193&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58366031 174008504 ZINC96177114 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224654 CC(C)(C)c1[nH]nc2C(=O)N(C(c12)c1ccccc1O)c1ccc(cc1)-c1ccon1 InChI=1S/C24H22N4O3/c1-24(2,3)22-19-20(25-26-22)23(30)28(21(19)16-6-4-5-7-18(16)29)15-10-8-14(9-11-15)17-12-13-31-27-17/h4-13,21,29H,1-3H3,(H,25,26) HMGGXXSYTOSHMX-UHFFFAOYSA-N 106194 US8575197, II-107 P2X purinoceptor 3 Homo sapiens 114 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106194 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106194&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365320 174008505 ZINC96177115 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224655 CC(C)(C)c1[nH]nc2C(=O)N(C(c12)c1ccccc1OCC#N)c1ccc(cc1)-c1ccon1 InChI=1S/C26H23N5O3/c1-26(2,3)24-21-22(28-29-24)25(32)31(17-10-8-16(9-11-17)19-12-14-34-30-19)23(21)18-6-4-5-7-20(18)33-15-13-27/h4-12,14,23H,15H2,1-3H3,(H,28,29) AALOCCXFNCWWFK-UHFFFAOYSA-N 106195 US8575197, II-108 P2X purinoceptor 3 Homo sapiens 15 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106195 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106195&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58366109 174008506 ZINC96177116 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224656 COc1ncccc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)CO)c1ccc(cc1)-c1ccsc1 InChI=1S/C25H24N4O3S/c1-25(2,14-30)22-19-20(27-28-22)24(31)29(21(19)18-5-4-11-26-23(18)32-3)17-8-6-15(7-9-17)16-10-12-33-13-16/h4-13,21,30H,14H2,1-3H3,(H,27,28) KWKGJUMLJHHNHN-UHFFFAOYSA-N 106196 US8575197, II-109 P2X purinoceptor 3 Homo sapiens 21 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106196 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106196&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365399 174008507 ZINC96177117 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224657 COc1ncccc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)CO)c1ccc(cc1)-c1cccs1 InChI=1S/C25H24N4O3S/c1-25(2,14-30)22-19-20(27-28-22)24(31)29(21(19)17-6-4-12-26-23(17)32-3)16-10-8-15(9-11-16)18-7-5-13-33-18/h4-13,21,30H,14H2,1-3H3,(H,27,28) NIUCMAZZRREORL-UHFFFAOYSA-N 106197 US8575197, II-110 P2X purinoceptor 3 Homo sapiens 24 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106197 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106197&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58366087 174008508 ZINC96177118 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224658 COc1ncccc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)CO)c1ccc(cc1)-c1ccco1 InChI=1S/C25H24N4O4/c1-25(2,14-30)22-19-20(27-28-22)24(31)29(21(19)17-6-4-12-26-23(17)32-3)16-10-8-15(9-11-16)18-7-5-13-33-18/h4-13,21,30H,14H2,1-3H3,(H,27,28) SKWLIVLURVOKAK-UHFFFAOYSA-N 106198 US8575197, II-111 P2X purinoceptor 3 Homo sapiens 91 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106198 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106198&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365683 174008509 ZINC96177119 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224659 CC(C)(C)c1[nH]nc2C(=O)N(C(c12)c1ccccc1S(C)(=O)=O)c1ccc(cc1)-c1ccon1 InChI=1S/C25H24N4O4S/c1-25(2,3)23-20-21(26-27-23)24(30)29(16-11-9-15(10-12-16)18-13-14-33-28-18)22(20)17-7-5-6-8-19(17)34(4,31)32/h5-14,22H,1-4H3,(H,26,27) YCKZWNVBHPDDDZ-UHFFFAOYSA-N 106199 US8575197, II-112 P2X purinoceptor 3 Homo sapiens 389 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106199 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106199&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365969 174008510 ZINC96177120 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224660 CC(C)(C)c1[nH]nc2C(=O)N(C(c12)c1ccccc1CO)c1ccc(cc1)-c1ccon1 InChI=1S/C25H24N4O3/c1-25(2,3)23-20-21(26-27-23)24(31)29(22(20)18-7-5-4-6-16(18)14-30)17-10-8-15(9-11-17)19-12-13-32-28-19/h4-13,22,30H,14H2,1-3H3,(H,26,27) AXBYIFMRGRWDOZ-UHFFFAOYSA-N 106200 US8575197, II-113 P2X purinoceptor 3 Homo sapiens 838 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106200 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106200&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365790 174008511 ZINC96177121 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224661 COCCOc1ccccc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)C)c1ccc(cc1)-c1cccs1 InChI=1S/C28H29N3O3S/c1-28(2,3)26-23-24(29-30-26)27(32)31(19-13-11-18(12-14-19)22-10-7-17-35-22)25(23)20-8-5-6-9-21(20)34-16-15-33-4/h5-14,17,25H,15-16H2,1-4H3,(H,29,30) CNPCVPBUMBNFJT-UHFFFAOYSA-N 106201 US8575197, II-114 P2X purinoceptor 3 Homo sapiens 12 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106201 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106201&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365680 174008512 ZINC96177122 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224662 COCCOc1ccccc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)C)c1ccc(cc1)-c1ccsc1 InChI=1S/C28H29N3O3S/c1-28(2,3)26-23-24(29-30-26)27(32)31(20-11-9-18(10-12-20)19-13-16-35-17-19)25(23)21-7-5-6-8-22(21)34-15-14-33-4/h5-13,16-17,25H,14-15H2,1-4H3,(H,29,30) QAMBHHJUAKBDON-UHFFFAOYSA-N 106202 US8575197, II-115 P2X purinoceptor 3 Homo sapiens 11 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106202 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106202&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365816 174008513 ZINC96177123 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224663 COc1ccc(cc1)-c1n[nH]c2C(=O)N(C(c12)c1ccccc1OCCO)c1nc2cc(OC)ccc2s1 InChI=1S/C28H24N4O5S/c1-35-17-9-7-16(8-10-17)24-23-25(31-30-24)27(34)32(26(23)19-5-3-4-6-21(19)37-14-13-33)28-29-20-15-18(36-2)11-12-22(20)38-28/h3-12,15,26,33H,13-14H2,1-2H3,(H,30,31) IYTYWVOUFWKUAK-UHFFFAOYSA-N 106204 US8575197, II-117 P2X purinoceptor 3 Homo sapiens 348 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106204 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106204&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365427 174008515 ZINC96177125 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224664 COc1ccc(cc1)-c1n[nH]c2C(=O)N(C(c12)c1ccccc1OCCO)c1nc2ccc(OC)cc2s1 InChI=1S/C28H24N4O5S/c1-35-17-9-7-16(8-10-17)24-23-25(31-30-24)27(34)32(26(23)19-5-3-4-6-21(19)37-14-13-33)28-29-20-12-11-18(36-2)15-22(20)38-28/h3-12,15,26,33H,13-14H2,1-2H3,(H,30,31) UPKKEMWTPBCPJG-UHFFFAOYSA-N 106205 US8575197, II-118 P2X purinoceptor 3 Homo sapiens 429 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106205 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106205&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365344 174008516 ZINC96177126 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224665 CN(C)c1ccccc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)C)c1ccc(cc1)-c1ccon1 InChI=1S/C26H27N5O2/c1-26(2,3)24-21-22(27-28-24)25(32)31(23(21)18-8-6-7-9-20(18)30(4)5)17-12-10-16(11-13-17)19-14-15-33-29-19/h6-15,23H,1-5H3,(H,27,28) IUILRNVCPMSUEG-UHFFFAOYSA-N 106206 US8575197, II-119 P2X purinoceptor 3 Homo sapiens 137 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106206 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106206&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365494 174008517 ZINC96177127 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224666 Cc1ncccc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)C)c1ccc(cc1)-c1cccs1 InChI=1S/C25H24N4OS/c1-15-18(7-5-13-26-15)22-20-21(27-28-23(20)25(2,3)4)24(30)29(22)17-11-9-16(10-12-17)19-8-6-14-31-19/h5-14,22H,1-4H3,(H,27,28) ZVPBSAWVQXYSJT-UHFFFAOYSA-N 106208 US8575197, II-121 P2X purinoceptor 3 Homo sapiens 464 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106208 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106208&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365603 174008519 ZINC96177129 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224667 Cc1ncccc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)C)c1ccc(cc1)-c1ccsc1 InChI=1S/C25H24N4OS/c1-15-19(6-5-12-26-15)22-20-21(27-28-23(20)25(2,3)4)24(30)29(22)18-9-7-16(8-10-18)17-11-13-31-14-17/h5-14,22H,1-4H3,(H,27,28) APAMFMKKIZBEKY-UHFFFAOYSA-N 106210 US8575197, II-123 P2X purinoceptor 3 Homo sapiens 431 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106210 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106210&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365978 174008521 ZINC96177131 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224668 CC(C)(C)c1[nH]nc2C(=O)N(C(c12)c1ccccc1OCCO)c1ccc(cc1)-c1ccoc1 InChI=1S/C27H27N3O4/c1-27(2,3)25-22-23(28-29-25)26(32)30(19-10-8-17(9-11-19)18-12-14-33-16-18)24(22)20-6-4-5-7-21(20)34-15-13-31/h4-12,14,16,24,31H,13,15H2,1-3H3,(H,28,29) JJICKBNLZQIFLK-UHFFFAOYSA-N 106211 US8575197, II-124 P2X purinoceptor 3 Homo sapiens 8 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106211 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106211&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58366084 174008522 ZINC96177132 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224669 COCCOc1ccccc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)C)c1ccc(cc1)-c1ccoc1 InChI=1S/C28H29N3O4/c1-28(2,3)26-23-24(29-30-26)27(32)31(20-11-9-18(10-12-20)19-13-14-34-17-19)25(23)21-7-5-6-8-22(21)35-16-15-33-4/h5-14,17,25H,15-16H2,1-4H3,(H,29,30) VLPNEZPEXSQOFN-UHFFFAOYSA-N 106212 US8575197, II-125 P2X purinoceptor 3 Homo sapiens 10 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106212 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106212&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365859 174008523 ZINC96177133 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224670 COCc1ncccc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)C)c1ccc(cc1)-c1ccsc1 InChI=1S/C26H26N4O2S/c1-26(2,3)24-21-22(28-29-24)25(31)30(23(21)19-6-5-12-27-20(19)14-32-4)18-9-7-16(8-10-18)17-11-13-33-15-17/h5-13,15,23H,14H2,1-4H3,(H,28,29) FZEUJUURRSQMNT-UHFFFAOYSA-N 106213 US8575197, II-126 P2X purinoceptor 3 Homo sapiens 221 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106213 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106213&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365560 174008524 ZINC96177134 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224671 CC(C)c1[nH]nc2C(=O)N(C(c12)c1ccccc1OCC#N)c1ccc(cc1)-c1ccsc1 InChI=1S/C26H22N4O2S/c1-16(2)23-22-24(29-28-23)26(31)30(19-9-7-17(8-10-19)18-11-14-33-15-18)25(22)20-5-3-4-6-21(20)32-13-12-27/h3-11,14-16,25H,13H2,1-2H3,(H,28,29) HKPAJFOFYHKKOW-UHFFFAOYSA-N 106214 US8575197, II-127 P2X purinoceptor 3 Homo sapiens 4 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106214 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106214&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365775 174008525 ZINC96177135 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224672 COC(=O)COCc1ncccc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)C)c1ccc(cc1)-c1ccsc1 InChI=1S/C28H28N4O4S/c1-28(2,3)26-23-24(30-31-26)27(34)32(19-9-7-17(8-10-19)18-11-13-37-16-18)25(23)20-6-5-12-29-21(20)14-36-15-22(33)35-4/h5-13,16,25H,14-15H2,1-4H3,(H,30,31) XDVBZOBDIKEWLI-UHFFFAOYSA-N 106215 US8575197, II-128 P2X purinoceptor 3 Homo sapiens 216 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106215 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106215&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365934 174008526 ZINC96177136 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224673 COCCOc1ccccc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)CO)c1ccc(cc1)-c1ccsc1 InChI=1S/C28H29N3O4S/c1-28(2,17-32)26-23-24(29-30-26)27(33)31(20-10-8-18(9-11-20)19-12-15-36-16-19)25(23)21-6-4-5-7-22(21)35-14-13-34-3/h4-12,15-16,25,32H,13-14,17H2,1-3H3,(H,29,30) POCNVSJBRFTFHL-UHFFFAOYSA-N 106217 US8575197, II-130 P2X purinoceptor 3 Homo sapiens 4 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106217 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106217&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365697 174008528 ZINC96177138 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224674 CC(C)(C)c1[nH]nc2C(=O)N(C(c12)c1ccccc1C(O)=O)c1ccc(cc1)-c1ccsc1 InChI=1S/C26H23N3O3S/c1-26(2,3)23-20-21(27-28-23)24(30)29(22(20)18-6-4-5-7-19(18)25(31)32)17-10-8-15(9-11-17)16-12-13-33-14-16/h4-14,22H,1-3H3,(H,27,28)(H,31,32) ISMCPEVLAKCDII-UHFFFAOYSA-N 106218 US8575197, II-131 P2X purinoceptor 3 Homo sapiens 88 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106218 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106218&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365588 174008529 ZINC96177139 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224675 COCCOc1ccccc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)CO)c1ccc(cc1)-c1ccon1 InChI=1S/C27H28N4O5/c1-27(2,16-32)25-22-23(28-29-25)26(33)31(18-10-8-17(9-11-18)20-12-13-36-30-20)24(22)19-6-4-5-7-21(19)35-15-14-34-3/h4-13,24,32H,14-16H2,1-3H3,(H,28,29) YNWWYVMHHXNAGJ-UHFFFAOYSA-N 106219 US8575197, II-132 P2X purinoceptor 3 Homo sapiens 141 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106219 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106219&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365397 174008530 ZINC96177140 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224676 COCc1ncccc1C1N(C(=O)c2n[nH]c(C(C)C)c12)c1ccc(cc1)-c1ccsc1 InChI=1S/C25H24N4O2S/c1-15(2)22-21-23(28-27-22)25(30)29(24(21)19-5-4-11-26-20(19)13-31-3)18-8-6-16(7-9-18)17-10-12-32-14-17/h4-12,14-15,24H,13H2,1-3H3,(H,27,28) PXTONIJFNVUFLN-UHFFFAOYSA-N 106220 US8575197, II-133 P2X purinoceptor 3 Homo sapiens 116 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106220 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106220&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365985 174008531 ZINC96177141 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224677 COc1ccccc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)CO)c1ccc(cc1)-c1cc(C)no1 InChI=1S/C26H26N4O4/c1-15-13-20(34-29-15)16-9-11-17(12-10-16)30-23(18-7-5-6-8-19(18)33-4)21-22(25(30)32)27-28-24(21)26(2,3)14-31/h5-13,23,31H,14H2,1-4H3,(H,27,28) RRGVDRVUDCUKHI-UHFFFAOYSA-N 106223 US8575197, II-136 P2X purinoceptor 3 Homo sapiens 55 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106223 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106223&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365661 174008534 ZINC96177144 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224678 COc1ccccc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)CO)c1ccc(cc1)-c1noc(C)n1 InChI=1S/C25H25N5O4/c1-14-26-23(29-34-14)15-9-11-16(12-10-15)30-21(17-7-5-6-8-18(17)33-4)19-20(24(30)32)27-28-22(19)25(2,3)13-31/h5-12,21,31H,13H2,1-4H3,(H,27,28) RYDPAQSRYQSWJJ-UHFFFAOYSA-N 106224 US8575197, II-137 P2X purinoceptor 3 Homo sapiens 148 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106224 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106224&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365871 174008535 ZINC96177145 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224679 COc1ccccc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)CO)c1ccc(cc1)-c1nc(C)no1 InChI=1S/C25H25N5O4/c1-14-26-23(34-29-14)15-9-11-16(12-10-15)30-21(17-7-5-6-8-18(17)33-4)19-20(24(30)32)27-28-22(19)25(2,3)13-31/h5-12,21,31H,13H2,1-4H3,(H,27,28) AYBDPRBWSXRQEE-UHFFFAOYSA-N 106225 US8575197, II-138 P2X purinoceptor 3 Homo sapiens 44 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106225 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106225&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365576 174008536 ZINC96177146 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224680 COc1ccccc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)CO)c1nc2ccccc2s1 InChI=1S/C23H22N4O3S/c1-23(2,12-28)20-17-18(25-26-20)21(29)27(19(17)13-8-4-6-10-15(13)30-3)22-24-14-9-5-7-11-16(14)31-22/h4-11,19,28H,12H2,1-3H3,(H,25,26) HDEXQVWSOCKBNV-UHFFFAOYSA-N 106226 US8575197, II-139 P2X purinoceptor 3 Homo sapiens 332 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106226 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106226&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365756 174008537 ZINC96177147 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224681 COc1ccccc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)CO)c1ccc(cc1)-c1nccs1 InChI=1S/C25H24N4O3S/c1-25(2,14-30)22-19-20(27-28-22)24(31)29(21(19)17-6-4-5-7-18(17)32-3)16-10-8-15(9-11-16)23-26-12-13-33-23/h4-13,21,30H,14H2,1-3H3,(H,27,28) PHAKDAHZFLAFIN-UHFFFAOYSA-N 106228 US8575197, II-141 P2X purinoceptor 3 Homo sapiens 22 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106228 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106228&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365924 174008539 ZINC96177149 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224682 COc1ccc2nc(sc2c1)N1C(c2c(n[nH]c2C(C)(C)CO)C1=O)c1ccccc1OC InChI=1S/C24H24N4O4S/c1-24(2,12-29)21-18-19(26-27-21)22(30)28(20(18)14-7-5-6-8-16(14)32-4)23-25-15-10-9-13(31-3)11-17(15)33-23/h5-11,20,29H,12H2,1-4H3,(H,26,27) WTIVHFPUPJVWIN-UHFFFAOYSA-N 106229 US8575197, II-142 P2X purinoceptor 3 Homo sapiens 104 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106229 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106229&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58366022 174008540 ZINC96177150 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224683 CCC(CC)(CO)c1[nH]nc2C(=O)N(C(c12)c1ccccc1OC)c1ccc(cc1)-c1ccon1 InChI=1S/C27H28N4O4/c1-4-27(5-2,16-32)25-22-23(28-29-25)26(33)31(24(22)19-8-6-7-9-21(19)34-3)18-12-10-17(11-13-18)20-14-15-35-30-20/h6-15,24,32H,4-5,16H2,1-3H3,(H,28,29) CPRIYILBXUAUBQ-UHFFFAOYSA-N 106232 US8575197, II-145 P2X purinoceptor 3 Homo sapiens 33 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106232 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106232&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365716 174008543 ZINC96177153 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224684 CNc1cc(on1)-c1ccc(cc1)N1C(c2c(n[nH]c2C(C)(C)C)C1=O)c1ccccc1OC InChI=1S/C26H27N5O3/c1-26(2,3)24-21-22(28-29-24)25(32)31(23(21)17-8-6-7-9-18(17)33-5)16-12-10-15(11-13-16)19-14-20(27-4)30-34-19/h6-14,23H,1-5H3,(H,27,30)(H,28,29) NQNPIFHZFZCZCS-UHFFFAOYSA-N 106233 US8575197, II-146 P2X purinoceptor 3 Homo sapiens 416 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106233 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106233&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365957 174008544 ZINC96177154 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224685 COc1ccccc1C1N(Cc2n[nH]c(C(C)C)c12)C(=O)Nc1ccc(cc1)-c1ccsc1 InChI=1S/C26H26N4O2S/c1-16(2)24-23-21(28-29-24)14-30(25(23)20-6-4-5-7-22(20)32-3)26(31)27-19-10-8-17(9-11-19)18-12-13-33-15-18/h4-13,15-16,25H,14H2,1-3H3,(H,27,31)(H,28,29) XYPAWMBGBRFICK-UHFFFAOYSA-N 106276 US8575197, II-189 P2X purinoceptor 3 Homo sapiens 897 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106276 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106276&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365909 174008587 ZINC96177197 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224686 COc1ncccc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)C)c1ccc(cc1)-c1cc(C)no1 InChI=1S/C25H25N5O3/c1-14-13-18(33-29-14)15-8-10-16(11-9-15)30-21(17-7-6-12-26-23(17)32-5)19-20(24(30)31)27-28-22(19)25(2,3)4/h6-13,21H,1-5H3,(H,27,28) QDQNBHXVLBPGGG-UHFFFAOYSA-N 106278 US8575197, II-191 P2X purinoceptor 3 Homo sapiens 322 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106278 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106278&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365629 174008589 ZINC96177199 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224687 COc1ncccc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)C)c1ccc(cc1)C1=NCCS1 InChI=1S/C24H25N5O2S/c1-24(2,3)20-17-18(27-28-20)23(30)29(19(17)16-6-5-11-25-21(16)31-4)15-9-7-14(8-10-15)22-26-12-13-32-22/h5-11,19H,12-13H2,1-4H3,(H,27,28) ALJZSPJFCTZKJK-UHFFFAOYSA-N 106279 US8575197, II-192 P2X purinoceptor 3 Homo sapiens 222 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106279 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106279&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58366007 174008590 ZINC96177200 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224688 COc1ncccc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)C)c1ccc(cc1)-c1nccs1 InChI=1S/C24H23N5O2S/c1-24(2,3)20-17-18(27-28-20)23(30)29(19(17)16-6-5-11-25-21(16)31-4)15-9-7-14(8-10-15)22-26-12-13-32-22/h5-13,19H,1-4H3,(H,27,28) NITBIKGZLOSRIX-UHFFFAOYSA-N 106280 US8575197, II-193 P2X purinoceptor 3 Homo sapiens 195 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106280 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106280&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365237 174008591 ZINC96177201 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224689 COc1ncccc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)C)c1ccc(cc1)-c1noc(C)n1 InChI=1S/C24H24N6O3/c1-13-26-21(29-33-13)14-8-10-15(11-9-14)30-19(16-7-6-12-25-22(16)32-5)17-18(23(30)31)27-28-20(17)24(2,3)4/h6-12,19H,1-5H3,(H,27,28) AKXTXVFUHJCOLA-UHFFFAOYSA-N 106281 US8575197, II-194 P2X purinoceptor 3 Homo sapiens 392 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106281 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106281&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58366096 174008592 ZINC96177202 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224690 COc1ncccc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)C)c1ccc(cc1)-c1nc(C)no1 InChI=1S/C24H24N6O3/c1-13-26-21(33-29-13)14-8-10-15(11-9-14)30-19(16-7-6-12-25-22(16)32-5)17-18(23(30)31)27-28-20(17)24(2,3)4/h6-12,19H,1-5H3,(H,27,28) DLGLUTUWPMORCF-UHFFFAOYSA-N 106282 US8575197, II-195 P2X purinoceptor 3 Homo sapiens 944 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106282 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106282&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365853 174008593 ZINC96177203 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224691 COc1ccccc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)C)c1ccc(C)cc1 InChI=1S/C23H25N3O2/c1-14-10-12-15(13-11-14)26-20(16-8-6-7-9-17(16)28-5)18-19(22(26)27)24-25-21(18)23(2,3)4/h6-13,20H,1-5H3,(H,24,25) NLLIPZAMDOVPBL-UHFFFAOYSA-N 106283 US8575197, II-196 P2X purinoceptor 3 Homo sapiens 783 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106283 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106283&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365771 174008594 ZINC96177204 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224692 COc1ccccc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)C)c1ccc(cc1)C(C)C InChI=1S/C25H29N3O2/c1-15(2)16-11-13-17(14-12-16)28-22(18-9-7-8-10-19(18)30-6)20-21(24(28)29)26-27-23(20)25(3,4)5/h7-15,22H,1-6H3,(H,26,27) FYEUFXSBGXVIFB-UHFFFAOYSA-N 106284 US8575197, II-197 P2X purinoceptor 3 Homo sapiens 106 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106284 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106284&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365504 174008595 ZINC96177205 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224693 COc1ccc(cc1)C1(CC1)c1[nH]nc2C(=O)N(C(c12)c1ccccc1OC)c1ccc(cc1)-c1ccon1 InChI=1S/C31H26N4O4/c1-37-22-13-9-20(10-14-22)31(16-17-31)29-26-27(32-33-29)30(36)35(28(26)23-5-3-4-6-25(23)38-2)21-11-7-19(8-12-21)24-15-18-39-34-24/h3-15,18,28H,16-17H2,1-2H3,(H,32,33) GKIWWGQPYVIAHH-UHFFFAOYSA-N 106285 US8575197, II-198 P2X purinoceptor 3 Homo sapiens 123 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106285 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106285&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365381 174008596 ZINC96177206 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224694 COc1ccccc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)c1ccccc1)c1ccc(cc1)-c1ccon1 InChI=1S/C30H26N4O3/c1-30(2,20-9-5-4-6-10-20)28-25-26(31-32-28)29(35)34(27(25)22-11-7-8-12-24(22)36-3)21-15-13-19(14-16-21)23-17-18-37-33-23/h4-18,27H,1-3H3,(H,31,32) AWPBWVLEIVSJAU-UHFFFAOYSA-N 106286 US8575197, II-199 P2X purinoceptor 3 Homo sapiens 113 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106286 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106286&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365796 174008597 ZINC96177207 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224695 COc1ccc(cc1)-c1n[nH]c2C(=O)N(Cc3cc(C)on3)C(C3CCCCC3)c12 InChI=1S/C23H26N4O3/c1-14-12-17(26-30-14)13-27-22(16-6-4-3-5-7-16)19-20(24-25-21(19)23(27)28)15-8-10-18(29-2)11-9-15/h8-12,16,22H,3-7,13H2,1-2H3,(H,24,25) OKAAPLDBZGJDAG-UHFFFAOYSA-N 106287 US8575197, II-200 P2X purinoceptor 3 Homo sapiens 448 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106287 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106287&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365627 174008598 ZINC96177208 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224696 COc1ccccc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)C)c1ccc(SC)cc1 InChI=1S/C23H25N3O2S/c1-23(2,3)21-18-19(24-25-21)22(27)26(14-10-12-15(29-5)13-11-14)20(18)16-8-6-7-9-17(16)28-4/h6-13,20H,1-5H3,(H,24,25) IUQRETOXVYWLAA-UHFFFAOYSA-N 106288 US8575197, II-201 P2X purinoceptor 3 Homo sapiens 33 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106288 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106288&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365950 174008599 ZINC96177209 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224697 COc1ccccc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)C)c1ccc(cc1)N(C)C InChI=1S/C24H28N4O2/c1-24(2,3)22-19-20(25-26-22)23(29)28(16-13-11-15(12-14-16)27(4)5)21(19)17-9-7-8-10-18(17)30-6/h7-14,21H,1-6H3,(H,25,26) XNOYSEZNLJXOGH-UHFFFAOYSA-N 106289 US8575197, II-202 P2X purinoceptor 3 Homo sapiens 76 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106289 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106289&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58366032 174008600 ZINC96177210 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224698 COc1ccccc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)C)c1ccc(cc1)-c1ccco1 InChI=1S/C26H25N3O3/c1-26(2,3)24-21-22(27-28-24)25(30)29(23(21)18-8-5-6-9-20(18)31-4)17-13-11-16(12-14-17)19-10-7-15-32-19/h5-15,23H,1-4H3,(H,27,28) ZBGOUGRLAHUUQI-UHFFFAOYSA-N 106290 US8575197, II-203 P2X purinoceptor 3 Homo sapiens 28 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106290 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106290&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58366080 174008601 ZINC96177211 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224699 COc1ccccc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)C)c1ccc(cc1)-c1ccsc1 InChI=1S/C26H25N3O2S/c1-26(2,3)24-21-22(27-28-24)25(30)29(23(21)19-7-5-6-8-20(19)31-4)18-11-9-16(10-12-18)17-13-14-32-15-17/h5-15,23H,1-4H3,(H,27,28) IJIRNLYMFCQLQL-UHFFFAOYSA-N 106291 US8575197, II-204 P2X purinoceptor 3 Homo sapiens 17 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106291 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106291&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365787 174008602 ZINC96177212 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224700 COc1ccccc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)C)c1ccc(cc1)-c1cccn1C InChI=1S/C27H28N4O2/c1-27(2,3)25-22-23(28-29-25)26(32)31(24(22)19-9-6-7-11-21(19)33-5)18-14-12-17(13-15-18)20-10-8-16-30(20)4/h6-16,24H,1-5H3,(H,28,29) JQYMLKCSVZQTPC-UHFFFAOYSA-N 106292 US8575197, II-205 P2X purinoceptor 3 Homo sapiens 811 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106292 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106292&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365987 174008603 ZINC96177213 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224701 COc1ccccc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)C)c1ccc(cc1)-c1ccccc1 InChI=1S/C28H27N3O2/c1-28(2,3)26-23-24(29-30-26)27(32)31(25(23)21-12-8-9-13-22(21)33-4)20-16-14-19(15-17-20)18-10-6-5-7-11-18/h5-17,25H,1-4H3,(H,29,30) AXUZDWAYBCAXLE-UHFFFAOYSA-N 106295 US8575197, II-208 P2X purinoceptor 3 Homo sapiens 112 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106295 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106295&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58366033 174008606 ZINC96177215 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224702 COc1ccccc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)C)c1ccc(cc1)-c1ncco1 InChI=1S/C25H24N4O3/c1-25(2,3)22-19-20(27-28-22)24(30)29(21(19)17-7-5-6-8-18(17)31-4)16-11-9-15(10-12-16)23-26-13-14-32-23/h5-14,21H,1-4H3,(H,27,28) LWHAQVIKMODEMM-UHFFFAOYSA-N 106296 US8575197, II-209 P2X purinoceptor 3 Homo sapiens 87 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106296 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106296&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58366024 174008607 ZINC96177216 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224703 COc1ncccc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)C)c1ccc(Br)cc1 InChI=1S/C21H21BrN4O2/c1-21(2,3)18-15-16(24-25-18)20(27)26(13-9-7-12(22)8-10-13)17(15)14-6-5-11-23-19(14)28-4/h5-11,17H,1-4H3,(H,24,25) JCWBTVPDEBKHMV-UHFFFAOYSA-N 106297 US8575197, II-210 P2X purinoceptor 3 Homo sapiens 811 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106297 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106297&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365341 174008608 ZINC96177217 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224704 COc1ccccc1C1N(C(=O)c2c1c(nn2C(=O)OC(C)(C)C)C(C)(C)C)c1ccc(Br)cc1 InChI=1S/C27H30BrN3O4/c1-26(2,3)23-20-21(18-10-8-9-11-19(18)34-7)30(17-14-12-16(28)13-15-17)24(32)22(20)31(29-23)25(33)35-27(4,5)6/h8-15,21H,1-7H3 YHVVVUUKCWSVQF-UHFFFAOYSA-N 106298 US8575197, II-211 P2X purinoceptor 3 Homo sapiens 135 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106298 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106298&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365681 174008609 ZINC96177218 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224705 COc1ccccc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)C)c1ccc(Br)cc1 InChI=1S/C22H22BrN3O2/c1-22(2,3)20-17-18(24-25-20)21(27)26(14-11-9-13(23)10-12-14)19(17)15-7-5-6-8-16(15)28-4/h5-12,19H,1-4H3,(H,24,25) SFDLZQOWHIXMER-UHFFFAOYSA-N 106299 US8575197, II-212 P2X purinoceptor 3 Homo sapiens 238 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106299 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106299&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365507 174008610 ZINC96177219 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224706 COc1ccccc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)C)c1ccc(cc1)-c1cccs1 InChI=1S/C26H25N3O2S/c1-26(2,3)24-21-22(27-28-24)25(30)29(23(21)18-8-5-6-9-19(18)31-4)17-13-11-16(12-14-17)20-10-7-15-32-20/h5-15,23H,1-4H3,(H,27,28) DRVADFAYXAOOKM-UHFFFAOYSA-N 106300 US8575197, II-213 P2X purinoceptor 3 Homo sapiens 11 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106300 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106300&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58366088 174008611 ZINC96177220 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224707 COc1ccccc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)CO)c1ccc(cc1)-c1ccco1 InChI=1S/C26H25N3O4/c1-26(2,15-30)24-21-22(27-28-24)25(31)29(23(21)18-7-4-5-8-20(18)32-3)17-12-10-16(11-13-17)19-9-6-14-33-19/h4-14,23,30H,15H2,1-3H3,(H,27,28) LMQYOZHEGQIRAZ-UHFFFAOYSA-N 106302 US8575197, II-215 P2X purinoceptor 3 Homo sapiens 15 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106302 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106302&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365951 174008613 ZINC96177222 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224708 COc1ccccc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)CO)c1ccc(Br)cc1 InChI=1S/C22H22BrN3O3/c1-22(2,12-27)20-17-18(24-25-20)21(28)26(14-10-8-13(23)9-11-14)19(17)15-6-4-5-7-16(15)29-3/h4-11,19,27H,12H2,1-3H3,(H,24,25) DGMVNSUVNQWTDU-UHFFFAOYSA-N 106303 US8575197, II-216 P2X purinoceptor 3 Homo sapiens 473 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106303 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106303&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365275 174008614 ZINC96177223 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224709 COc1ccccc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)CO)c1ccc(cc1)-c1ccsc1 InChI=1S/C26H25N3O3S/c1-26(2,15-30)24-21-22(27-28-24)25(31)29(23(21)19-6-4-5-7-20(19)32-3)18-10-8-16(9-11-18)17-12-13-33-14-17/h4-14,23,30H,15H2,1-3H3,(H,27,28) LOUCUHNCGCXYRF-UHFFFAOYSA-N 106304 US8575197, II-217 P2X purinoceptor 3 Homo sapiens 3 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106304 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106304&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365251 174008615 ZINC96177224 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224710 COc1ccccc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)CO)c1ccc(cc1)-c1cccs1 InChI=1S/C26H25N3O3S/c1-26(2,15-30)24-21-22(27-28-24)25(31)29(23(21)18-7-4-5-8-19(18)32-3)17-12-10-16(11-13-17)20-9-6-14-33-20/h4-14,23,30H,15H2,1-3H3,(H,27,28) DPTCSHBJFKDBDZ-UHFFFAOYSA-N 106305 US8575197, II-218 P2X purinoceptor 3 Homo sapiens 5 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106305 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106305&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365487 174008616 ZINC96177225 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224711 COc1ccccc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)CO)c1ccc(cc1)-c1ccoc1 InChI=1S/C26H25N3O4/c1-26(2,15-30)24-21-22(27-28-24)25(31)29(23(21)19-6-4-5-7-20(19)32-3)18-10-8-16(9-11-18)17-12-13-33-14-17/h4-14,23,30H,15H2,1-3H3,(H,27,28) WERHYZDXUWDKJM-UHFFFAOYSA-N 106306 US8575197, II-219 P2X purinoceptor 3 Homo sapiens 14 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106306 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106306&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365551 174008617 ZINC96177226 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224712 COc1ncccc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)C)c1ccc(cc1)-c1ccoc1 InChI=1S/C25H24N4O3/c1-25(2,3)22-19-20(27-28-22)24(30)29(21(19)18-6-5-12-26-23(18)31-4)17-9-7-15(8-10-17)16-11-13-32-14-16/h5-14,21H,1-4H3,(H,27,28) NFVFXFSBPPIFRH-UHFFFAOYSA-N 106307 US8575197, II-220 P2X purinoceptor 3 Homo sapiens 69 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106307 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106307&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365837 174008618 ZINC96177227 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224713 COc1ncccc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)C)c1ccc(cc1)-c1ccsc1 InChI=1S/C25H24N4O2S/c1-25(2,3)22-19-20(27-28-22)24(30)29(21(19)18-6-5-12-26-23(18)31-4)17-9-7-15(8-10-17)16-11-13-32-14-16/h5-14,21H,1-4H3,(H,27,28) LSSUSQHCQGYITH-UHFFFAOYSA-N 106310 US8575197, II-223 P2X purinoceptor 3 Homo sapiens 23 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106310 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106310&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365601 174008621 ZINC96177230 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224714 COc1ncccc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)C)c1ccc(cc1)-c1cccs1 InChI=1S/C25H24N4O2S/c1-25(2,3)22-19-20(27-28-22)24(30)29(21(19)17-7-5-13-26-23(17)31-4)16-11-9-15(10-12-16)18-8-6-14-32-18/h5-14,21H,1-4H3,(H,27,28) UVPNUKVCVOTRBQ-UHFFFAOYSA-N 106311 US8575197, II-224 P2X purinoceptor 3 Homo sapiens 31 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106311 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106311&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365958 174008622 ZINC96177231 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224715 COc1ccc(cc1)-c1n[nH]c2C(=O)N(CCc3ccco3)C(c12)c1ccccc1OC InChI=1S/C25H23N3O4/c1-30-17-11-9-16(10-12-17)22-21-23(27-26-22)25(29)28(14-13-18-6-5-15-32-18)24(21)19-7-3-4-8-20(19)31-2/h3-12,15,24H,13-14H2,1-2H3,(H,26,27) GOAZOMQLBVFWJP-UHFFFAOYSA-N 106312 US8575197, II-225 P2X purinoceptor 3 Homo sapiens 979 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106312 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106312&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365460 174008623 ZINC96177232 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224716 COc1ccccc1[C@H]1N(C(=O)c2n[nH]c(c12)C(C)(C)CO)c1ccc(cc1)-c1ccon1 InChI=1S/C25H24N4O4/c1-25(2,14-30)23-20-21(26-27-23)24(31)29(22(20)17-6-4-5-7-19(17)32-3)16-10-8-15(9-11-16)18-12-13-33-28-18/h4-13,22,30H,14H2,1-3H3,(H,26,27)/t22-/m1/s1 FZHVSOARDFCKBS-JOCHJYFZSA-N 106314 US8575197, II-227 P2X purinoceptor 3 Homo sapiens 34 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106314 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106314&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365720 174008625 ZINC96177234 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224717 COC(=O)n1nc(c2C(N(C(=O)c12)c1ccc(Br)cc1)c1ccccc1OC)C(C)(C)C InChI=1S/C24H24BrN3O4/c1-24(2,3)21-18-19(16-8-6-7-9-17(16)31-4)27(15-12-10-14(25)11-13-15)22(29)20(18)28(26-21)23(30)32-5/h6-13,19H,1-5H3 OHWKLOJVIJDUNM-UHFFFAOYSA-N 106316 US8575197, II-229 P2X purinoceptor 3 Homo sapiens 82 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106316 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106316&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365944 174008627 ZINC96177236 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224718 COc1ccc(cc1)-c1n[nH]c2C(=O)N(CCCc3ccco3)C(c12)c1ccccc1OC InChI=1S/C26H25N3O4/c1-31-18-13-11-17(12-14-18)23-22-24(28-27-23)26(30)29(15-5-7-19-8-6-16-33-19)25(22)20-9-3-4-10-21(20)32-2/h3-4,6,8-14,16,25H,5,7,15H2,1-2H3,(H,27,28) VPIORGQQTUCDAT-UHFFFAOYSA-N 106318 US8575197, II-231 P2X purinoceptor 3 Homo sapiens 344 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106318 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106318&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365429 174008629 ZINC96177238 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224719 COc1ccccc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)CO)c1ccc(cc1)-c1cc[nH]c1 InChI=1S/C26H26N4O3/c1-26(2,15-31)24-21-22(28-29-24)25(32)30(23(21)19-6-4-5-7-20(19)33-3)18-10-8-16(9-11-18)17-12-13-27-14-17/h4-14,23,27,31H,15H2,1-3H3,(H,28,29) MESOWKYWFARCJO-UHFFFAOYSA-N 106319 US8575197, II-232 P2X purinoceptor 3 Homo sapiens 16 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106319 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106319&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365347 174008630 ZINC96177239 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224720 CC(C)c1[nH]nc2C(=O)N(C(c12)c1ccccn1)c1ccc(cc1)-c1ccsc1 InChI=1S/C23H20N4OS/c1-14(2)20-19-21(26-25-20)23(28)27(22(19)18-5-3-4-11-24-18)17-8-6-15(7-9-17)16-10-12-29-13-16/h3-14,22H,1-2H3,(H,25,26) ZLTKSWVKSNFZRX-UHFFFAOYSA-N 106320 US8575197, II-233 P2X purinoceptor 3 Homo sapiens 92 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106320 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106320&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58366110 174008631 ZINC96177240 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224721 CC(C)(CO)c1[nH]nc2C(=O)N(C(c12)c1ccccn1)c1ccc(cc1)-c1ccsc1 InChI=1S/C24H22N4O2S/c1-24(2,14-29)22-19-20(26-27-22)23(30)28(21(19)18-5-3-4-11-25-18)17-8-6-15(7-9-17)16-10-12-31-13-16/h3-13,21,29H,14H2,1-2H3,(H,26,27) AGUGIXYYNHCLBD-UHFFFAOYSA-N 106321 US8575197, II-234 P2X purinoceptor 3 Homo sapiens 130 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106321 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106321&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365983 174008632 ZINC96177241 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224722 COc1ccccc1C1N(C(=O)c2n[nH]c(C(C)C)c12)c1ccc(-c2ccsc2)c(OC)c1 InChI=1S/C26H25N3O3S/c1-15(2)23-22-24(28-27-23)26(30)29(25(22)19-7-5-6-8-20(19)31-3)17-9-10-18(21(13-17)32-4)16-11-12-33-14-16/h5-15,25H,1-4H3,(H,27,28) ZVNNDSSYZMNCAG-UHFFFAOYSA-N 106322 US8575197, II-235 P2X purinoceptor 3 Homo sapiens 17 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106322 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106322&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58366010 174008633 ZINC96177242 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224723 CC(C)c1[nH]nc2C(=O)N(C(c12)c1ccccc1OC(CO)CO)c1ccc(cc1)-c1ccsc1 InChI=1S/C27H27N3O4S/c1-16(2)24-23-25(29-28-24)27(33)30(19-9-7-17(8-10-19)18-11-12-35-15-18)26(23)21-5-3-4-6-22(21)34-20(13-31)14-32/h3-12,15-16,20,26,31-32H,13-14H2,1-2H3,(H,28,29) ORYUFZWTSCZXOY-UHFFFAOYSA-N 106323 US8575197, II-236 P2X purinoceptor 3 Homo sapiens 5 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106323 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106323&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365253 174008634 ZINC96177243 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224724 COc1ccccc1C1N(C(=O)c2n[nH]c(C(C)C)c12)c1ccc(-c2ccsc2)c(NC(C)=O)c1 InChI=1S/C27H26N4O3S/c1-15(2)24-23-25(30-29-24)27(33)31(26(23)20-7-5-6-8-22(20)34-4)18-9-10-19(17-11-12-35-14-17)21(13-18)28-16(3)32/h5-15,26H,1-4H3,(H,28,32)(H,29,30) KSQVGFPVKMSAMF-UHFFFAOYSA-N 106324 US8575197, II-237 P2X purinoceptor 3 Homo sapiens 853 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106324 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106324&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365376 174008635 ZINC96177244 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224725 COc1ccccc1C1N(C(=O)c2n[nH]c(C(C)C)c12)c1ccc(-c2ccsc2)c(F)c1 InChI=1S/C25H22FN3O2S/c1-14(2)22-21-23(28-27-22)25(30)29(24(21)18-6-4-5-7-20(18)31-3)16-8-9-17(19(26)12-16)15-10-11-32-13-15/h4-14,24H,1-3H3,(H,27,28) PIFKEMFZXUIVTR-UHFFFAOYSA-N 106325 US8575197, II-238 P2X purinoceptor 3 Homo sapiens 19 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106325 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106325&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58366054 174008636 ZINC96177245 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224726 COc1ccccc1C1N(C(=O)c2n[nH]c(C(C)C)c12)c1ccc(-c2ccsc2)c(C)c1 InChI=1S/C26H25N3O2S/c1-15(2)23-22-24(28-27-23)26(30)29(25(22)20-7-5-6-8-21(20)31-4)18-9-10-19(16(3)13-18)17-11-12-32-14-17/h5-15,25H,1-4H3,(H,27,28) QCHDCGSWGJDCBU-UHFFFAOYSA-N 106326 US8575197, II-239 P2X purinoceptor 3 Homo sapiens 205 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106326 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106326&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365630 174008637 ZINC96177246 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224727 COc1ccccc1C1N(C(=O)c2n[nH]c(C(C)C)c12)c1ccc(-c2ccsc2)c(N)c1 InChI=1S/C25H24N4O2S/c1-14(2)22-21-23(28-27-22)25(30)29(24(21)18-6-4-5-7-20(18)31-3)16-8-9-17(19(26)12-16)15-10-11-32-13-15/h4-14,24H,26H2,1-3H3,(H,27,28) VWFDSJHVQDPLLO-UHFFFAOYSA-N 106327 US8575197, II-240 P2X purinoceptor 3 Homo sapiens 116 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106327 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106327&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365269 174008638 ZINC96177247 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224728 COC(=O)c1cc(ccc1-c1ccsc1)N1C(c2c([nH]nc2C1=O)C(C)C)c1ccccc1OC InChI=1S/C27H25N3O4S/c1-15(2)23-22-24(29-28-23)26(31)30(25(22)19-7-5-6-8-21(19)33-3)17-9-10-18(16-11-12-35-14-16)20(13-17)27(32)34-4/h5-15,25H,1-4H3,(H,28,29) CBJFCYPAYLSOHC-UHFFFAOYSA-N 106328 US8575197, II-241 P2X purinoceptor 3 Homo sapiens 213 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106328 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106328&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365571 174008639 ZINC96177248 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224729 COc1ccccc1C1N(C(=O)c2n[nH]c(C(C)C)c12)c1ccc(-c2ccsc2)c(c1)C(N)=O InChI=1S/C26H24N4O3S/c1-14(2)22-21-23(29-28-22)26(32)30(24(21)18-6-4-5-7-20(18)33-3)16-8-9-17(15-10-11-34-13-15)19(12-16)25(27)31/h4-14,24H,1-3H3,(H2,27,31)(H,28,29) KNSMRLFZPWFOIS-UHFFFAOYSA-N 106329 US8575197, II-242 P2X purinoceptor 3 Homo sapiens 152 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106329 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106329&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365446 174008640 ZINC96177249 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224730 COc1ccccc1C1N(C(=O)c2n[nH]c(C(C)C)c12)c1ccc(-c2ccsc2)c(CO)c1 InChI=1S/C26H25N3O3S/c1-15(2)23-22-24(28-27-23)26(31)29(25(22)20-6-4-5-7-21(20)32-3)18-8-9-19(17(12-18)13-30)16-10-11-33-14-16/h4-12,14-15,25,30H,13H2,1-3H3,(H,27,28) RUVAAUVNDXHTED-UHFFFAOYSA-N 106330 US8575197, II-243 P2X purinoceptor 3 Homo sapiens 138 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106330 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106330&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365559 174008641 ZINC96177250 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224731 COc1ccccc1C1N(C(=O)c2n[nH]c(C(C)C)c12)c1ccc(-c2ccsc2)c(c1)N(C)C InChI=1S/C27H28N4O2S/c1-16(2)24-23-25(29-28-24)27(32)31(26(23)20-8-6-7-9-22(20)33-5)18-10-11-19(17-12-13-34-15-17)21(14-18)30(3)4/h6-16,26H,1-5H3,(H,28,29) ZZSOJMVNNWGVTK-UHFFFAOYSA-N 106331 US8575197, II-244 P2X purinoceptor 3 Homo sapiens 144 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106331 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106331&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365653 174008642 ZINC96177251 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224732 CC(C)c1[nH]nc2C(=O)N(C(c12)c1ccccc1OCCS(C)(=O)=O)c1ccc(cc1)-c1ccsc1 InChI=1S/C27H27N3O4S2/c1-17(2)24-23-25(29-28-24)27(31)30(20-10-8-18(9-11-20)19-12-14-35-16-19)26(23)21-6-4-5-7-22(21)34-13-15-36(3,32)33/h4-12,14,16-17,26H,13,15H2,1-3H3,(H,28,29) IQEUQZTZOVJAAI-UHFFFAOYSA-N 106332 US8575197, II-245 P2X purinoceptor 3 Homo sapiens 6 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106332 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106332&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365456 174008643 ZINC96177252 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224733 COc1ccccc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)C)c1ccc(Br)cn1 InChI=1S/C21H21BrN4O2/c1-21(2,3)19-16-17(24-25-19)20(27)26(15-10-9-12(22)11-23-15)18(16)13-7-5-6-8-14(13)28-4/h5-11,18H,1-4H3,(H,24,25) MOUQUSSXULGVJU-UHFFFAOYSA-N 106333 US8575197, II-246 P2X purinoceptor 3 Homo sapiens 871 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106333 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106333&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365322 174008644 ZINC96177253 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224734 CC(C)c1[nH]nc2C(=O)N(C(c12)c1ccccc1OCC(=O)NN)c1ccc(cc1)-c1ccsc1 InChI=1S/C26H25N5O3S/c1-15(2)23-22-24(30-29-23)26(33)31(18-9-7-16(8-10-18)17-11-12-35-14-17)25(22)19-5-3-4-6-20(19)34-13-21(32)28-27/h3-12,14-15,25H,13,27H2,1-2H3,(H,28,32)(H,29,30) DHZHKWIQYOMQDP-UHFFFAOYSA-N 106138 US8575197, II-051 P2X purinoceptor 3 Homo sapiens 5 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106138 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106138&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68275797 174008449 ZINC96177059 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224735 CC(C)c1[nH]nc2C(=O)N(C(c12)c1cccnc1OCC(O)=O)c1ccc(cc1)-c1ccsc1 InChI=1S/C25H22N4O4S/c1-14(2)21-20-22(28-27-21)25(32)29(17-7-5-15(6-8-17)16-9-11-34-13-16)23(20)18-4-3-10-26-24(18)33-12-19(30)31/h3-11,13-14,23H,12H2,1-2H3,(H,27,28)(H,30,31) BDOZHEBVXSRUBI-UHFFFAOYSA-N 106139 US8575197, II-052 P2X purinoceptor 3 Homo sapiens 33 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106139 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106139&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365483 174008450 ZINC96177060 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224736 CNC(=O)COc1ncccc1C1N(C(=O)c2n[nH]c(C(C)C)c12)c1ccc(cc1)-c1ccsc1 InChI=1S/C26H25N5O3S/c1-15(2)22-21-23(30-29-22)26(33)31(18-8-6-16(7-9-18)17-10-12-35-14-17)24(21)19-5-4-11-28-25(19)34-13-20(32)27-3/h4-12,14-15,24H,13H2,1-3H3,(H,27,32)(H,29,30) XKZQXBAFNOPWMO-UHFFFAOYSA-N 106140 US8575197, II-053 P2X purinoceptor 3 Homo sapiens 35 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106140 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106140&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58366038 174008451 ZINC96177061 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224737 CC(C)c1[nH]nc2C(=O)N(C(c12)c1cccnc1OCC(N)=O)c1ccc(cc1)-c1ccsc1 InChI=1S/C25H23N5O3S/c1-14(2)21-20-22(29-28-21)25(32)30(17-7-5-15(6-8-17)16-9-11-34-13-16)23(20)18-4-3-10-27-24(18)33-12-19(26)31/h3-11,13-14,23H,12H2,1-2H3,(H2,26,31)(H,28,29) KITUTIUOONDNBY-UHFFFAOYSA-N 106141 US8575197, II-054 P2X purinoceptor 3 Homo sapiens 26 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106141 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106141&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365297 174008452 ZINC96177062 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224738 COc1ccc(cc1)-c1n[nH]c2C(=O)N(C(C3CCCCC3)c12)c1ccc2[nH]ccc2c1 InChI=1S/C26H26N4O2/c1-32-20-10-7-16(8-11-20)23-22-24(29-28-23)26(31)30(25(22)17-5-3-2-4-6-17)19-9-12-21-18(15-19)13-14-27-21/h7-15,17,25,27H,2-6H2,1H3,(H,28,29) SEESTDWSGXROMT-UHFFFAOYSA-N 106142 US8575197, II-055 P2X purinoceptor 3 Homo sapiens 548 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106142 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106142&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365923 174008453 ZINC96177063 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224739 CCOC(=O)c1ccc(cc1)N1C(c2c(n[nH]c2C(C)(C)C)C1=O)c1ccccc1OC InChI=1S/C25H27N3O4/c1-6-32-24(30)15-11-13-16(14-12-15)28-21(17-9-7-8-10-18(17)31-5)19-20(23(28)29)26-27-22(19)25(2,3)4/h7-14,21H,6H2,1-5H3,(H,26,27) ZQIRBVQPHGRYRK-UHFFFAOYSA-N 106144 US8575197, II-057 P2X purinoceptor 3 Homo sapiens 17 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106144 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106144&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365762 174008455 ZINC96177065 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224740 CC(C)(C)c1n[nH]c2C(=O)N(C(c12)c1cccc[n+]1[O-])c1ccc(cc1)-c1cc[o+][n-]1 InChI=1S/C23H21N5O3/c1-23(2,3)21-18-19(24-25-21)22(29)28(20(18)17-6-4-5-12-27(17)30)15-9-7-14(8-10-15)16-11-13-31-26-16/h4-13,20H,1-3H3,(H,24,25) IHUVVDYSRIKCEA-UHFFFAOYSA-N 106145 US8575197, II-058 P2X purinoceptor 3 Homo sapiens 494 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106145 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106145&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365820 174008456 ZINC96177066 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224741 COc1cc(F)ccc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)C)c1ccc(cc1)-c1ccon1 InChI=1S/C25H23FN4O3/c1-25(2,3)23-20-21(27-28-23)24(31)30(22(20)17-10-7-15(26)13-19(17)32-4)16-8-5-14(6-9-16)18-11-12-33-29-18/h5-13,22H,1-4H3,(H,27,28) LBRFJCIIPJRSQN-UHFFFAOYSA-N 106146 US8575197, II-059 P2X purinoceptor 3 Homo sapiens 46 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106146 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106146&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58366035 174008457 ZINC96177067 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224742 COc1cccc(OC)c1C1N(C(=O)c2n[nH]c(c12)C(C)(C)C)c1ccc(cc1)-c1ccon1 InChI=1S/C26H26N4O4/c1-26(2,3)24-21-22(27-28-24)25(31)30(16-11-9-15(10-12-16)17-13-14-34-29-17)23(21)20-18(32-4)7-6-8-19(20)33-5/h6-14,23H,1-5H3,(H,27,28) WCCXFFLJPHNRDB-UHFFFAOYSA-N 106147 US8575197, II-060 P2X purinoceptor 3 Homo sapiens 538 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106147 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106147&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365443 174008458 ZINC96177068 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224743 CC(C)(C)c1[nH]nc2C(=O)N(C(c12)c1ccccc1OC(F)(F)F)c1ccc(cc1)-c1ccon1 InChI=1S/C25H21F3N4O3/c1-24(2,3)22-19-20(29-30-22)23(33)32(15-10-8-14(9-11-15)17-12-13-34-31-17)21(19)16-6-4-5-7-18(16)35-25(26,27)28/h4-13,21H,1-3H3,(H,29,30) MMUPKNYVRZDQOY-UHFFFAOYSA-N 106148 US8575197, II-061 P2X purinoceptor 3 Homo sapiens 166 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106148 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106148&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365772 174008459 ZINC96177069 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224744 COc1ccc(F)cc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)C)c1ccc(cc1)-c1ccon1 InChI=1S/C25H23FN4O3/c1-25(2,3)23-20-21(27-28-23)24(31)30(22(20)17-13-15(26)7-10-19(17)32-4)16-8-5-14(6-9-16)18-11-12-33-29-18/h5-13,22H,1-4H3,(H,27,28) POSLWHBYLLKDOK-UHFFFAOYSA-N 106149 US8575197, II-062 P2X purinoceptor 3 Homo sapiens 112 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106149 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106149&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365333 174008460 ZINC96177070 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224745 COc1ccccc1C1N(C(=O)c2n[nH]c(c12)C1(CO)CCCCC1)c1ccc(cc1)-c1ccon1 InChI=1S/C28H28N4O4/c1-35-22-8-4-3-7-20(22)25-23-24(29-30-26(23)28(17-33)14-5-2-6-15-28)27(34)32(25)19-11-9-18(10-12-19)21-13-16-36-31-21/h3-4,7-13,16,25,33H,2,5-6,14-15,17H2,1H3,(H,29,30) JMXLSNYYPJBULK-UHFFFAOYSA-N 106151 US8575197, II-064 P2X purinoceptor 3 Homo sapiens 75 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106151 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106151&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365566 174008462 ZINC96177072 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224746 COc1ccccc1C1N(Cc2n[nH]c(C(C)C)c12)c1ccc(cc1)-c1ccsc1 InChI=1S/C25H25N3OS/c1-16(2)24-23-21(26-27-24)14-28(25(23)20-6-4-5-7-22(20)29-3)19-10-8-17(9-11-19)18-12-13-30-15-18/h4-13,15-16,25H,14H2,1-3H3,(H,26,27) DTXRJGKAECMPJW-UHFFFAOYSA-N 106154 US8575197, II-067 P2X purinoceptor 3 Homo sapiens 153 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106154 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106154&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365966 174008465 ZINC96177075 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224747 COCc1ccccc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)C)c1ccc(cc1)-c1cc(C)no1 InChI=1S/C27H28N4O3/c1-16-14-21(34-30-16)17-10-12-19(13-11-17)31-24(20-9-7-6-8-18(20)15-33-5)22-23(26(31)32)28-29-25(22)27(2,3)4/h6-14,24H,15H2,1-5H3,(H,28,29) BFLRPVQLWNWKCX-UHFFFAOYSA-N 106155 US8575197, II-068 P2X purinoceptor 3 Homo sapiens 508 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106155 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106155&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365808 174008466 ZINC96177076 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224748 COCc1ccccc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)C)c1ccc(cc1)-c1noc(C)n1 InChI=1S/C26H27N5O3/c1-15-27-24(30-34-15)16-10-12-18(13-11-16)31-22(19-9-7-6-8-17(19)14-33-5)20-21(25(31)32)28-29-23(20)26(2,3)4/h6-13,22H,14H2,1-5H3,(H,28,29) ZCABCNTZSKYKFR-UHFFFAOYSA-N 106156 US8575197, II-069 P2X purinoceptor 3 Homo sapiens 414 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106156 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106156&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365607 174008467 ZINC96177077 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224749 COc1ccccc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)C)c1ccc(CN(C)C)cc1 InChI=1S/C25H30N4O2/c1-25(2,3)23-20-21(26-27-23)24(30)29(17-13-11-16(12-14-17)15-28(4)5)22(20)18-9-7-8-10-19(18)31-6/h7-14,22H,15H2,1-6H3,(H,26,27) MAENUSOLJGIHQJ-UHFFFAOYSA-N 106159 US8575197, II-072 P2X purinoceptor 3 Homo sapiens 739 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106159 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106159&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365350 174008470 ZINC96177080 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224750 COc1ccccc1C1N(C(=O)c2n[nH]c(CC(C)(C)C)c12)c1ccc(cc1)-c1ccon1 InChI=1S/C26H26N4O3/c1-26(2,3)15-20-22-23(28-27-20)25(31)30(24(22)18-7-5-6-8-21(18)32-4)17-11-9-16(10-12-17)19-13-14-33-29-19/h5-14,24H,15H2,1-4H3,(H,27,28) WWDHYUSDBHRABX-UHFFFAOYSA-N 106160 US8575197, II-073 P2X purinoceptor 3 Homo sapiens 105 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106160 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106160&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58366149 174008471 ZINC96177081 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224751 CC(C)(C)c1n[nH]c2C(=O)N(C(c12)c1cccc[n+]1[O-])c1ccc(cc1)-c1ccsc1 InChI=1S/C24H22N4O2S/c1-24(2,3)22-19-20(25-26-22)23(29)28(21(19)18-6-4-5-12-27(18)30)17-9-7-15(8-10-17)16-11-13-31-14-16/h4-14,21H,1-3H3,(H,25,26) YWAJAOSMBKUQGW-UHFFFAOYSA-N 106161 US8575197, II-074 P2X purinoceptor 3 Homo sapiens 32 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106161 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106161&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365334 174008472 ZINC96177082 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224752 CC(C)(C)c1[nH]nc2C(=O)N(C(c12)c1ccccc1OCC(N)=O)c1ccc(cc1)-c1ccon1 InChI=1S/C26H25N5O4/c1-26(2,3)24-21-22(28-29-24)25(33)31(16-10-8-15(9-11-16)18-12-13-35-30-18)23(21)17-6-4-5-7-19(17)34-14-20(27)32/h4-13,23H,14H2,1-3H3,(H2,27,32)(H,28,29) YKWUFTGCFBCSOU-UHFFFAOYSA-N 106162 US8575197, II-075 P2X purinoceptor 3 Homo sapiens 153 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106162 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106162&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365511 174008473 ZINC96177083 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224753 CS(=O)CCOc1ccccc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)C)c1ccc(cc1)-c1ccsc1 InChI=1S/C28H29N3O3S2/c1-28(2,3)26-23-24(29-30-26)27(32)31(20-11-9-18(10-12-20)19-13-15-35-17-19)25(23)21-7-5-6-8-22(21)34-14-16-36(4)33/h5-13,15,17,25H,14,16H2,1-4H3,(H,29,30) KLNMVNYXFOBDEA-UHFFFAOYSA-N 106163 US8575197, II-076 P2X purinoceptor 3 Homo sapiens 12 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106163 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106163&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365509 174008474 ZINC96177084 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224754 CNC(=O)COc1ccccc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)C)c1ccc(cc1)-c1ccon1 InChI=1S/C27H27N5O4/c1-27(2,3)25-22-23(29-30-25)26(34)32(17-11-9-16(10-12-17)19-13-14-36-31-19)24(22)18-7-5-6-8-20(18)35-15-21(33)28-4/h5-14,24H,15H2,1-4H3,(H,28,33)(H,29,30) XNODKRDDVCLGGQ-UHFFFAOYSA-N 106164 US8575197, II-077 P2X purinoceptor 3 Homo sapiens 237 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106164 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106164&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58366132 174008475 ZINC96177085 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224755 CC(C)c1[nH]nc2C(=O)N(C(c12)c1ccccc1OCCN(C)C)c1ccc(cc1)-c1ccsc1 InChI=1S/C28H30N4O2S/c1-18(2)25-24-26(30-29-25)28(33)32(21-11-9-19(10-12-21)20-13-16-35-17-20)27(24)22-7-5-6-8-23(22)34-15-14-31(3)4/h5-13,16-18,27H,14-15H2,1-4H3,(H,29,30) BLHVQYLBFKUZOV-UHFFFAOYSA-N 106165 US8575197, II-078 P2X purinoceptor 3 Homo sapiens 16 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106165 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106165&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365671 174008476 ZINC96177086 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224756 COc1ccccc1C1N(C(=O)c2n[nH]c(C(C)C)c12)c1ccc(cc1)-c1ccsc1 InChI=1S/C25H23N3O2S/c1-15(2)22-21-23(27-26-22)25(29)28(24(21)19-6-4-5-7-20(19)30-3)18-10-8-16(9-11-18)17-12-13-31-14-17/h4-15,24H,1-3H3,(H,26,27) VBMQGLDMEBMZSP-UHFFFAOYSA-N 106166 US8575197, II-079 P2X purinoceptor 3 Homo sapiens 11 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106166 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106166&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365339 174008477 ZINC96177087 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224757 CC(C)c1[nH]nc2C(=O)N(C(c12)c1ccccc1OCCS(C)=O)c1ccc(cc1)-c1ccsc1 InChI=1S/C27H27N3O3S2/c1-17(2)24-23-25(29-28-24)27(31)30(20-10-8-18(9-11-20)19-12-14-34-16-19)26(23)21-6-4-5-7-22(21)33-13-15-35(3)32/h4-12,14,16-17,26H,13,15H2,1-3H3,(H,28,29) CUXHNVOSINIFPX-UHFFFAOYSA-N 106167 US8575197, II-080 P2X purinoceptor 3 Homo sapiens 11 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106167 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106167&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365497 174008478 ZINC96177088 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224758 CC(C)c1[nH]nc2C(=O)N(C(c12)c1ccccc1N)c1ccc(cc1)-c1ccsc1 InChI=1S/C24H22N4OS/c1-14(2)21-20-22(27-26-21)24(29)28(23(20)18-5-3-4-6-19(18)25)17-9-7-15(8-10-17)16-11-12-30-13-16/h3-14,23H,25H2,1-2H3,(H,26,27) SMGDZPVXWRFQIZ-UHFFFAOYSA-N 106168 US8575197, II-081 P2X purinoceptor 3 Homo sapiens 189 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106168 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106168&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365457 174008479 ZINC96177089 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224759 CC(C)c1[nH]nc2C(=O)N(C(c12)c1ccccc1N(C)C(C)=O)c1ccc(cc1)-c1ccsc1 InChI=1S/C27H26N4O2S/c1-16(2)24-23-25(29-28-24)27(33)31(20-11-9-18(10-12-20)19-13-14-34-15-19)26(23)21-7-5-6-8-22(21)30(4)17(3)32/h5-16,26H,1-4H3,(H,28,29) RTEPNEPDVWGNFR-UHFFFAOYSA-N 106169 US8575197, II-082 P2X purinoceptor 3 Homo sapiens 44 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106169 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106169&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365968 174008480 ZINC96177090 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224760 COc1ccccc1C1N(C(=O)c2n[nH]c(C3CC3)c12)c1ccc(cc1)-c1ccsc1 InChI=1S/C25H21N3O2S/c1-30-20-5-3-2-4-19(20)24-21-22(16-6-7-16)26-27-23(21)25(29)28(24)18-10-8-15(9-11-18)17-12-13-31-14-17/h2-5,8-14,16,24H,6-7H2,1H3,(H,26,27) AQUTUFGFJLCBPZ-UHFFFAOYSA-N 106170 US8575197, II-083 P2X purinoceptor 3 Homo sapiens 24 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106170 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106170&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365799 174008481 ZINC96177091 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224761 CC(C)c1[nH]nc2C(=O)N(C(c12)c1ccccc1CN(C)C)c1ccc(cc1)-c1ccsc1 InChI=1S/C27H28N4OS/c1-17(2)24-23-25(29-28-24)27(32)31(21-11-9-18(10-12-21)20-13-14-33-16-20)26(23)22-8-6-5-7-19(22)15-30(3)4/h5-14,16-17,26H,15H2,1-4H3,(H,28,29) NXNZWHDHFFXHOJ-UHFFFAOYSA-N 106171 US8575197, II-084 P2X purinoceptor 3 Homo sapiens 18 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106171 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106171&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365815 174008482 ZINC96177092 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224762 CC(C)c1[nH]nc2C(=O)N(C(c12)c1ccccc1NC(C)=O)c1ccc(cc1)-c1ccsc1 InChI=1S/C26H24N4O2S/c1-15(2)23-22-24(29-28-23)26(32)30(19-10-8-17(9-11-19)18-12-13-33-14-18)25(22)20-6-4-5-7-21(20)27-16(3)31/h4-15,25H,1-3H3,(H,27,31)(H,28,29) HVXHQUYUNMTUGG-UHFFFAOYSA-N 106172 US8575197, II-085 P2X purinoceptor 3 Homo sapiens 23 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106172 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106172&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365242 174008483 ZINC96177093 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224763 CC(C)c1[nH]nc2C(=O)N(C(c12)c1ccccc1CO)c1ccc(cc1)-c1ccsc1 InChI=1S/C25H23N3O2S/c1-15(2)22-21-23(27-26-22)25(30)28(24(21)20-6-4-3-5-17(20)13-29)19-9-7-16(8-10-19)18-11-12-31-14-18/h3-12,14-15,24,29H,13H2,1-2H3,(H,26,27) NOYKQNZKAJDOJG-UHFFFAOYSA-N 106173 US8575197, II-086 P2X purinoceptor 3 Homo sapiens 32 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106173 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106173&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365745 174008484 ZINC96177094 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224764 CC(C)c1[nH]nc2C(=O)N(C(c12)c1ccccc1NC(N)=O)c1ccc(cc1)-c1ccsc1 InChI=1S/C25H23N5O2S/c1-14(2)21-20-22(29-28-21)24(31)30(17-9-7-15(8-10-17)16-11-12-33-13-16)23(20)18-5-3-4-6-19(18)27-25(26)32/h3-14,23H,1-2H3,(H,28,29)(H3,26,27,32) RFNCKXSIOPEZIU-UHFFFAOYSA-N 106174 US8575197, II-087 P2X purinoceptor 3 Homo sapiens 9 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106174 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106174&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365361 174008485 ZINC96177095 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224765 COc1ccccc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)C)c1ccc(cc1)-c1cc(NC(C)=O)no1 InChI=1S/C27H27N5O4/c1-15(33)28-21-14-20(36-31-21)16-10-12-17(13-11-16)32-24(18-8-6-7-9-19(18)35-5)22-23(26(32)34)29-30-25(22)27(2,3)4/h6-14,24H,1-5H3,(H,29,30)(H,28,31,33) PCPRTCJOTAPBEV-UHFFFAOYSA-N 106234 US8575197, II-147 P2X purinoceptor 3 Homo sapiens 977 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106234 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106234&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58366068 174008545 ZINC96177155 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224766 COc1ccccc1C1N(C(=O)c2[nH]nc(c12)C(F)(F)F)c1ccc(cc1)-c1ccon1 InChI=1S/C22H15F3N4O3/c1-31-16-5-3-2-4-14(16)19-17-18(26-27-20(17)22(23,24)25)21(30)29(19)13-8-6-12(7-9-13)15-10-11-32-28-15/h2-11,19H,1H3,(H,26,27) CRHARBBGOHVXEO-UHFFFAOYSA-N 106235 US8575197, II-148 P2X purinoceptor 3 Homo sapiens 311 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106235 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106235&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58366049 174008546 ZINC96177156 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224767 COc1ccccc1C1N(C(=O)c2n[nH]c(C(C)=C)c12)c1ccc(cc1)-c1ccon1 InChI=1S/C24H20N4O3/c1-14(2)21-20-22(26-25-21)24(29)28(23(20)17-6-4-5-7-19(17)30-3)16-10-8-15(9-11-16)18-12-13-31-27-18/h4-13,23H,1H2,2-3H3,(H,25,26) VWIZIEQYYHQKQM-UHFFFAOYSA-N 106236 US8575197, II-149 P2X purinoceptor 3 Homo sapiens 377 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106236 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106236&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365754 174008547 ZINC96177157 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224768 COc1ccccc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)C)c1ccc(cc1)C(C)(C)O InChI=1S/C25H29N3O3/c1-24(2,3)22-19-20(26-27-22)23(29)28(16-13-11-15(12-14-16)25(4,5)30)21(19)17-9-7-8-10-18(17)31-6/h7-14,21,30H,1-6H3,(H,26,27) ILUZOIBPEBHOQH-UHFFFAOYSA-N 106238 US8575197, II-151 P2X purinoceptor 3 Homo sapiens 650 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106238 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106238&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365289 174008549 ZINC96177159 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224769 COc1ccccc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)C)c1ccc(cc1)C(C)=O InChI=1S/C24H25N3O3/c1-14(28)15-10-12-16(13-11-15)27-21(17-8-6-7-9-18(17)30-5)19-20(23(27)29)25-26-22(19)24(2,3)4/h6-13,21H,1-5H3,(H,25,26) FCVIPWKIFDNAMQ-UHFFFAOYSA-N 106242 US8575197, II-155 P2X purinoceptor 3 Homo sapiens 322 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106242 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106242&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365414 174008553 ZINC96177163 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224770 CO\N=C(\C)c1ccc(cc1)N1C(c2c(n[nH]c2C(C)(C)C)C1=O)c1ccccc1OC InChI=1S/C25H28N4O3/c1-15(28-32-6)16-11-13-17(14-12-16)29-22(18-9-7-8-10-19(18)31-5)20-21(24(29)30)26-27-23(20)25(2,3)4/h7-14,22H,1-6H3,(H,26,27)/b28-15- SUSXTKKRRKSDCU-MBTHVWNTSA-N 106243 US8575197, II-156 P2X purinoceptor 3 Homo sapiens 412 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106243 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106243&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365411 174008554 ZINC96177164 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224771 COc1ccccc1C1N(C(=O)c2[nH]nc(c12)C(C)(C)C(O)=O)c1ccc(cc1)-c1ccon1 InChI=1S/C25H22N4O5/c1-25(2,24(31)32)22-19-20(26-27-22)23(30)29(21(19)16-6-4-5-7-18(16)33-3)15-10-8-14(9-11-15)17-12-13-34-28-17/h4-13,21H,1-3H3,(H,26,27)(H,31,32) DDOPVGMUOWTKNK-UHFFFAOYSA-N 106244 US8575197, II-157 P2X purinoceptor 3 Homo sapiens 524 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106244 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106244&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365612 174008555 ZINC96177165 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224772 CNC(=O)C(C)(C)c1n[nH]c2C(=O)N(C(c12)c1ccccc1OC)c1ccc(cc1)-c1ccon1 InChI=1S/C26H25N5O4/c1-26(2,25(33)27-3)23-20-21(28-29-23)24(32)31(22(20)17-7-5-6-8-19(17)34-4)16-11-9-15(10-12-16)18-13-14-35-30-18/h5-14,22H,1-4H3,(H,27,33)(H,28,29) JVMACEIIAGASHP-UHFFFAOYSA-N 106245 US8575197, II-158 P2X purinoceptor 3 Homo sapiens 650 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106245 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106245&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365247 174008556 ZINC96177166 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224773 COc1ccccc1C1N(C(=O)c2[nH]nc(c12)C(C)(C)C(=O)N(C)C)c1ccc(cc1)-c1ccon1 InChI=1S/C27H27N5O4/c1-27(2,26(34)31(3)4)24-21-22(28-29-24)25(33)32(23(21)18-8-6-7-9-20(18)35-5)17-12-10-16(11-13-17)19-14-15-36-30-19/h6-15,23H,1-5H3,(H,28,29) ICHJYVZRVXNKCH-UHFFFAOYSA-N 106246 US8575197, II-159 P2X purinoceptor 3 Homo sapiens 360 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106246 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106246&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365303 174008557 ZINC96177167 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224774 COc1ccccc1C1N(C(=O)c2[nH]nc(c12)C(C)(C)C(O)=O)c1ccc(cc1)-c1cccs1 InChI=1S/C26H23N3O4S/c1-26(2,25(31)32)23-20-21(27-28-23)24(30)29(22(20)17-7-4-5-8-18(17)33-3)16-12-10-15(11-13-16)19-9-6-14-34-19/h4-14,22H,1-3H3,(H,27,28)(H,31,32) SNOCJUWHSZHBSZ-UHFFFAOYSA-N 106250 US8575197, II-163 P2X purinoceptor 3 Homo sapiens 34 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106250 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106250&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365884 174008561 ZINC96177171 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224775 CC(C)(C)c1[nH]nc2C(=O)N(C(c12)c1cccc[n+]1[O-])c1ccc(cc1)-c1cccs1 InChI=1S/C24H22N4O2S/c1-24(2,3)22-19-20(25-26-22)23(29)28(21(19)17-7-4-5-13-27(17)30)16-11-9-15(10-12-16)18-8-6-14-31-18/h4-14,21H,1-3H3,(H,25,26) ZTFNFNRVSHTOCP-UHFFFAOYSA-N 106251 US8575197, II-164 P2X purinoceptor 3 Homo sapiens 36 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106251 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106251&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58366048 174008562 ZINC96177172 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224776 COc1ccccc1C1N(C(=O)c2[nH]nc(c12)C(C)(C)C(O)=O)c1ccc(cc1)-c1ccsc1 InChI=1S/C26H23N3O4S/c1-26(2,25(31)32)23-20-21(27-28-23)24(30)29(22(20)18-6-4-5-7-19(18)33-3)17-10-8-15(9-11-17)16-12-13-34-14-16/h4-14,22H,1-3H3,(H,27,28)(H,31,32) OUCSBKHLAPPJKF-UHFFFAOYSA-N 106252 US8575197, II-165 P2X purinoceptor 3 Homo sapiens 41 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106252 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106252&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365874 174008563 ZINC96177173 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224777 CN(C)C(=O)COc1ccccc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)C)c1ccc(cc1)-c1ccsc1 InChI=1S/C29H30N4O3S/c1-29(2,3)27-24-25(30-31-27)28(35)33(20-12-10-18(11-13-20)19-14-15-37-17-19)26(24)21-8-6-7-9-22(21)36-16-23(34)32(4)5/h6-15,17,26H,16H2,1-5H3,(H,30,31) RPDMWVRCIMYXQN-UHFFFAOYSA-N 106253 US8575197, II-166 P2X purinoceptor 3 Homo sapiens 7 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106253 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106253&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365851 174008564 ZINC96177174 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224778 CNC(=O)COc1ccccc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)C)c1ccc(cc1)-c1ccsc1 InChI=1S/C28H28N4O3S/c1-28(2,3)26-23-24(30-31-26)27(34)32(19-11-9-17(10-12-19)18-13-14-36-16-18)25(23)20-7-5-6-8-21(20)35-15-22(33)29-4/h5-14,16,25H,15H2,1-4H3,(H,29,33)(H,30,31) VOFGOKVYRRNVAA-UHFFFAOYSA-N 106254 US8575197, II-167 P2X purinoceptor 3 Homo sapiens 5 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106254 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106254&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365773 174008565 ZINC96177175 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224779 CS(=O)CCOc1ccccc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)C)c1ccc(cc1)-c1ccon1 InChI=1S/C27H28N4O4S/c1-27(2,3)25-22-23(28-29-25)26(32)31(18-11-9-17(10-12-18)20-13-14-35-30-20)24(22)19-7-5-6-8-21(19)34-15-16-36(4)33/h5-14,24H,15-16H2,1-4H3,(H,28,29) IQPORZKSIUGYLE-UHFFFAOYSA-N 106255 US8575197, II-168 P2X purinoceptor 3 Homo sapiens 101 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106255 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106255&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365617 174008566 ZINC96177176 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224780 CC(C)(C)c1[nH]nc2C(=O)N(C(c12)c1ccccc1OCC(N)=O)c1ccc(cc1)-c1ccsc1 InChI=1S/C27H26N4O3S/c1-27(2,3)25-22-23(29-30-25)26(33)31(18-10-8-16(9-11-18)17-12-13-35-15-17)24(22)19-6-4-5-7-20(19)34-14-21(28)32/h4-13,15,24H,14H2,1-3H3,(H2,28,32)(H,29,30) SZQXBQNWIQDXPC-UHFFFAOYSA-N 106256 US8575197, II-169 P2X purinoceptor 3 Homo sapiens 4 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106256 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106256&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365784 174008567 ZINC96177177 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224781 CNC(=O)C(C)(C)c1n[nH]c2C(=O)N(C(c12)c1ccccc1OC)c1ccc(cc1)-c1ccsc1 InChI=1S/C27H26N4O3S/c1-27(2,26(33)28-3)24-21-22(29-30-24)25(32)31(23(21)19-7-5-6-8-20(19)34-4)18-11-9-16(10-12-18)17-13-14-35-15-17/h5-15,23H,1-4H3,(H,28,33)(H,29,30) FNLVQWMLAOTHFC-UHFFFAOYSA-N 106257 US8575197, II-170 P2X purinoceptor 3 Homo sapiens 34 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106257 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106257&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58366043 174008568 ZINC96177178 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224782 CC(C)(C)c1[nH]nc2C(=O)N(C(c12)c1ccccc1OCCNS(C)(=O)=O)c1ccc(cc1)-c1ccsc1 InChI=1S/C28H30N4O4S2/c1-28(2,3)26-23-24(30-31-26)27(33)32(20-11-9-18(10-12-20)19-13-16-37-17-19)25(23)21-7-5-6-8-22(21)36-15-14-29-38(4,34)35/h5-13,16-17,25,29H,14-15H2,1-4H3,(H,30,31) TXMNFPYPGLEXQP-UHFFFAOYSA-N 106258 US8575197, II-171 P2X purinoceptor 3 Homo sapiens 7 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106258 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106258&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68276950 174008569 ZINC96177179 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224783 COc1ccccc1C1N(C(=O)c2[nH]nc(c12)C(C)(C)C(=O)N(C)C)c1ccc(cc1)-c1ccsc1 InChI=1S/C28H28N4O3S/c1-28(2,27(34)31(3)4)25-22-23(29-30-25)26(33)32(24(22)20-8-6-7-9-21(20)35-5)19-12-10-17(11-13-19)18-14-15-36-16-18/h6-16,24H,1-5H3,(H,29,30) XJDCIMZLASNJIE-UHFFFAOYSA-N 106259 US8575197, II-172 P2X purinoceptor 3 Homo sapiens 11 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106259 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106259&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365920 174008570 ZINC96177180 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224784 CC(C)(C)c1[nH]nc2C(=O)N(C(c12)c1ccccc1OCC#N)c1ccc(cc1)-c1ccsc1 InChI=1S/C27H24N4O2S/c1-27(2,3)25-22-23(29-30-25)26(32)31(19-10-8-17(9-11-19)18-12-15-34-16-18)24(22)20-6-4-5-7-21(20)33-14-13-28/h4-12,15-16,24H,14H2,1-3H3,(H,29,30) YBJLWRFYSBDGMC-UHFFFAOYSA-N 106260 US8575197, II-173 P2X purinoceptor 3 Homo sapiens 4 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106260 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106260&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365792 174008571 ZINC96177181 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224785 CC(C)(C)c1[nH]nc2C(=O)N(C(c12)c1ccccc1OCc1nnn[nH]1)c1ccc(cc1)-c1ccsc1 InChI=1S/C27H25N7O2S/c1-27(2,3)25-22-23(30-31-25)26(35)34(18-10-8-16(9-11-18)17-12-13-37-15-17)24(22)19-6-4-5-7-20(19)36-14-21-28-32-33-29-21/h4-13,15,24H,14H2,1-3H3,(H,30,31)(H,28,29,32,33) ODRDXISBDWRQIB-UHFFFAOYSA-N 106261 US8575197, II-174 P2X purinoceptor 3 Homo sapiens 3 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106261 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106261&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365628 174008572 ZINC96177182 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224786 CC(C)c1[nH]nc2C(=O)N(C(c12)c1ccccc1OCc1nnn[nH]1)c1ccc(cc1)-c1ccsc1 InChI=1S/C26H23N7O2S/c1-15(2)23-22-24(30-29-23)26(34)33(18-9-7-16(8-10-18)17-11-12-36-14-17)25(22)19-5-3-4-6-20(19)35-13-21-27-31-32-28-21/h3-12,14-15,25H,13H2,1-2H3,(H,29,30)(H,27,28,31,32) MGOSAUNYFOBIMR-UHFFFAOYSA-N 106262 US8575197, II-175 P2X purinoceptor 3 Homo sapiens 3 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106262 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106262&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365326 174008573 ZINC96177183 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224787 CC(C)c1[nH]nc2C(=O)N(C(c12)c1ccccc1OCCNC(C)=O)c1ccc(cc1)-c1ccsc1 InChI=1S/C28H28N4O3S/c1-17(2)25-24-26(31-30-25)28(34)32(21-10-8-19(9-11-21)20-12-15-36-16-20)27(24)22-6-4-5-7-23(22)35-14-13-29-18(3)33/h4-12,15-17,27H,13-14H2,1-3H3,(H,29,33)(H,30,31) MUGSMTPEWDAYCM-UHFFFAOYSA-N 106263 US8575197, II-176 P2X purinoceptor 3 Homo sapiens 10 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106263 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106263&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365279 174008574 ZINC96177184 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224788 COc1ccccc1C1N(C(=O)c2[nH]nc(-c3ccco3)c12)c1ccc(cc1)-c1ccsc1 InChI=1S/C26H19N3O3S/c1-31-20-6-3-2-5-19(20)25-22-23(21-7-4-13-32-21)27-28-24(22)26(30)29(25)18-10-8-16(9-11-18)17-12-14-33-15-17/h2-15,25H,1H3,(H,27,28) CFAHOOMYUWGZCG-UHFFFAOYSA-N 106265 US8575197, II-178 P2X purinoceptor 3 Homo sapiens 149 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106265 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106265&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365870 174008576 ZINC96177186 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224789 COc1ccccc1C1N(C(=O)c2[nH]nc(C(=O)N(C)C)c12)c1ccc(cc1)-c1ccsc1 InChI=1S/C25H22N4O3S/c1-28(2)24(30)21-20-22(27-26-21)25(31)29(23(20)18-6-4-5-7-19(18)32-3)17-10-8-15(9-11-17)16-12-13-33-14-16/h4-14,23H,1-3H3,(H,26,27) FNYZKTQJNRCIFV-UHFFFAOYSA-N 106267 US8575197, II-180 P2X purinoceptor 3 Homo sapiens 262 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106267 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106267&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365578 174008578 ZINC96177188 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224790 CNC(=O)c1n[nH]c2C(=O)N(C(c12)c1ccccc1OC)c1ccc(cc1)-c1ccsc1 InChI=1S/C24H20N4O3S/c1-25-23(29)20-19-21(27-26-20)24(30)28(22(19)17-5-3-4-6-18(17)31-2)16-9-7-14(8-10-16)15-11-12-32-13-15/h3-13,22H,1-2H3,(H,25,29)(H,26,27) ONUWLLJMHDGJQP-UHFFFAOYSA-N 106268 US8575197, II-181 P2X purinoceptor 3 Homo sapiens 301 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106268 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106268&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58366041 174008579 ZINC96177189 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224791 COc1ccccc1C1N(C(=O)c2[nH]nc(CO)c12)c1ccc(cc1)-c1ccsc1 InChI=1S/C23H19N3O3S/c1-29-19-5-3-2-4-17(19)22-20-18(12-27)24-25-21(20)23(28)26(22)16-8-6-14(7-9-16)15-10-11-30-13-15/h2-11,13,22,27H,12H2,1H3,(H,24,25) WMZYLHLHTSBKPW-UHFFFAOYSA-N 106269 US8575197, II-182 P2X purinoceptor 3 Homo sapiens 60 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106269 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106269&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365591 174008580 ZINC96177190 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224792 CCOC(=O)C1N(C(=O)c2n[nH]c(C(C)C)c12)c1ccc(cc1)-c1ccsc1 InChI=1S/C21H21N3O3S/c1-4-27-21(26)19-16-17(12(2)3)22-23-18(16)20(25)24(19)15-7-5-13(6-8-15)14-9-10-28-11-14/h5-12,19H,4H2,1-3H3,(H,22,23) FCYQUHJPWLCGAB-UHFFFAOYSA-N 106270 US8575197, II-183 P2X purinoceptor 3 Homo sapiens 460 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106270 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106270&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365935 174008581 ZINC96177191 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224793 CC(C)c1[nH]nc2C(=O)N(C(c12)c1ccccc1OCC(C)(C)O)c1ccc(cc1)-c1ccsc1 InChI=1S/C28H29N3O3S/c1-17(2)24-23-25(30-29-24)27(32)31(20-11-9-18(10-12-20)19-13-14-35-15-19)26(23)21-7-5-6-8-22(21)34-16-28(3,4)33/h5-15,17,26,33H,16H2,1-4H3,(H,29,30) JIXBBGQQGKPOBZ-UHFFFAOYSA-N 106271 US8575197, II-184 P2X purinoceptor 3 Homo sapiens 12 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106271 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106271&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365847 174008582 ZINC96177192 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 224794 CC(C)c1[nH]nc2C(=O)N(C(c12)c1ccccc1OCC(=N)NO)c1ccc(cc1)-c1ccsc1 InChI=1S/C26H25N5O3S/c1-15(2)23-22-24(29-28-23)26(32)31(18-9-7-16(8-10-18)17-11-12-35-14-17)25(22)19-5-3-4-6-20(19)34-13-21(27)30-33/h3-12,14-15,25,33H,13H2,1-2H3,(H2,27,30)(H,28,29) DNMIHHCPGLMLJL-UHFFFAOYSA-N 106272 US8575197, II-185 P2X purinoceptor 3 Homo sapiens 11 US Patent 10.7270/Q2CN72KP aid1800140 US8575197 Kai, H; Taoda, Y; Endoh, T; Asahi, K; Tobinaga, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106272 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106272&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365529 174008583 ZINC96177193 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 244264 CC(Nc1ncnc2CCN(Cc12)c1ccc(C)cn1)c1cccc(F)c1 InChI=1S/C21H22FN5/c1-14-6-7-20(23-11-14)27-9-8-19-18(12-27)21(25-13-24-19)26-15(2)16-4-3-5-17(22)10-16/h3-7,10-11,13,15H,8-9,12H2,1-2H3,(H,24,25,26) GJAUWURFLVNMPO-UHFFFAOYSA-N 118107 US8653091, 2 P2X purinoceptor 3 Homo sapiens 56 US Patent 10.7270/Q20G3HTJ aid1800362 US8653091 Wei, Z; Kincaid, J; Kelly, MG; O'Mahony, DJ; Kaub, C Evotec AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118107 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118107&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 25033010 199998491 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 244265 CC(Nc1ncnc2CCN(Cc12)c1ccc(C)cn1)c1cccc(c1)C(F)(F)F InChI=1S/C22H22F3N5/c1-14-6-7-20(26-11-14)30-9-8-19-18(12-30)21(28-13-27-19)29-15(2)16-4-3-5-17(10-16)22(23,24)25/h3-7,10-11,13,15H,8-9,12H2,1-2H3,(H,27,28,29) RDXICZFIIAPTMJ-UHFFFAOYSA-N 118109 US8653091, 4 P2X purinoceptor 3 Homo sapiens 301 US Patent 10.7270/Q20G3HTJ aid1800362 US8653091 Wei, Z; Kincaid, J; Kelly, MG; O'Mahony, DJ; Kaub, C Evotec AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118109 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118109&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 25033012 199998493 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 244266 CC(Nc1ncnc2CCN(Cc12)c1ccc(C)cn1)c1ccc(cc1)S(C)(=O)=O InChI=1S/C22H25N5O2S/c1-15-4-9-21(23-12-15)27-11-10-20-19(13-27)22(25-14-24-20)26-16(2)17-5-7-18(8-6-17)30(3,28)29/h4-9,12,14,16H,10-11,13H2,1-3H3,(H,24,25,26) VEHRIESAOMHDBK-UHFFFAOYSA-N 118110 US8653091, 5 P2X purinoceptor 3 Homo sapiens 128 US Patent 10.7270/Q20G3HTJ aid1800362 US8653091 Wei, Z; Kincaid, J; Kelly, MG; O'Mahony, DJ; Kaub, C Evotec AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118110 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118110&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 25033013 199998494 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 244267 C[C@H](Nc1ncnc2CCN(Cc12)c1ccc(C)cn1)c1ccc(Cl)cc1 InChI=1S/C21H22ClN5/c1-14-3-8-20(23-11-14)27-10-9-19-18(12-27)21(25-13-24-19)26-15(2)16-4-6-17(22)7-5-16/h3-8,11,13,15H,9-10,12H2,1-2H3,(H,24,25,26)/t15-/m0/s1 NAJWMPSVESSMGN-HNNXBMFYSA-N 118111 US8653091, 6 P2X purinoceptor 3 Homo sapiens >7200 US Patent 10.7270/Q20G3HTJ aid1800362 US8653091 Wei, Z; Kincaid, J; Kelly, MG; O'Mahony, DJ; Kaub, C Evotec AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118111 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118111&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 25033014 199998495 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 244268 C[C@@H](Nc1ncnc2CCN(Cc12)c1ccc(C)cn1)c1ccc(Cl)cc1 InChI=1S/C21H22ClN5/c1-14-3-8-20(23-11-14)27-10-9-19-18(12-27)21(25-13-24-19)26-15(2)16-4-6-17(22)7-5-16/h3-8,11,13,15H,9-10,12H2,1-2H3,(H,24,25,26)/t15-/m1/s1 NAJWMPSVESSMGN-OAHLLOKOSA-N 118112 US8653091, 7 P2X purinoceptor 3 Homo sapiens 48 US Patent 10.7270/Q20G3HTJ aid1800362 US8653091 Wei, Z; Kincaid, J; Kelly, MG; O'Mahony, DJ; Kaub, C Evotec AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118112 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118112&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 25033086 199998496 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 244269 C[C@@H](Nc1ncnc2CCN(Cc12)c1ccc(C)cn1)c1ccccc1 InChI=1S/C21H23N5/c1-15-8-9-20(22-12-15)26-11-10-19-18(13-26)21(24-14-23-19)25-16(2)17-6-4-3-5-7-17/h3-9,12,14,16H,10-11,13H2,1-2H3,(H,23,24,25)/t16-/m1/s1 PODLAPNQWXJKQM-MRXNPFEDSA-N 118113 US8653091, 8 P2X purinoceptor 3 Homo sapiens 73 US Patent 10.7270/Q20G3HTJ aid1800362 US8653091 Wei, Z; Kincaid, J; Kelly, MG; O'Mahony, DJ; Kaub, C Evotec AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118113 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118113&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 25033087 199998497 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 244270 CC(Nc1ncnc2CCN(Cc12)c1ccc(C)cn1)c1ccncc1 InChI=1S/C20H22N6/c1-14-3-4-19(22-11-14)26-10-7-18-17(12-26)20(24-13-23-18)25-15(2)16-5-8-21-9-6-16/h3-6,8-9,11,13,15H,7,10,12H2,1-2H3,(H,23,24,25) QVWXUUHKIMGPFG-UHFFFAOYSA-N 118114 US8653091, 9 P2X purinoceptor 3 Homo sapiens 212 US Patent 10.7270/Q20G3HTJ aid1800362 US8653091 Wei, Z; Kincaid, J; Kelly, MG; O'Mahony, DJ; Kaub, C Evotec AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118114 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118114&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 25033088 199998498 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 244271 CC(Nc1ncnc2CCN(Cc12)c1ccc(C)cn1)c1ccccn1 InChI=1S/C20H22N6/c1-14-6-7-19(22-11-14)26-10-8-18-16(12-26)20(24-13-23-18)25-15(2)17-5-3-4-9-21-17/h3-7,9,11,13,15H,8,10,12H2,1-2H3,(H,23,24,25) UUWHBMBIWZIRLD-UHFFFAOYSA-N 118115 US8653091, 10 P2X purinoceptor 3 Homo sapiens 123 US Patent 10.7270/Q20G3HTJ aid1800362 US8653091 Wei, Z; Kincaid, J; Kelly, MG; O'Mahony, DJ; Kaub, C Evotec AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118115 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118115&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 25033089 199998499 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 244272 CC(Nc1ncnc2CCN(Cc12)c1ccc(C)cn1)c1cccnc1 InChI=1S/C20H22N6/c1-14-5-6-19(22-10-14)26-9-7-18-17(12-26)20(24-13-23-18)25-15(2)16-4-3-8-21-11-16/h3-6,8,10-11,13,15H,7,9,12H2,1-2H3,(H,23,24,25) KHKPRVFTDKPHCV-UHFFFAOYSA-N 118116 US8653091, 11 P2X purinoceptor 3 Homo sapiens 63 US Patent 10.7270/Q20G3HTJ aid1800362 US8653091 Wei, Z; Kincaid, J; Kelly, MG; O'Mahony, DJ; Kaub, C Evotec AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118116 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118116&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 25033090 199998500 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 244273 CC(Nc1ncnc2CCN(Cc12)c1ccc(C)cn1)c1ccccc1F InChI=1S/C21H22FN5/c1-14-7-8-20(23-11-14)27-10-9-19-17(12-27)21(25-13-24-19)26-15(2)16-5-3-4-6-18(16)22/h3-8,11,13,15H,9-10,12H2,1-2H3,(H,24,25,26) GGDAJJXTRCEWJF-UHFFFAOYSA-N 118117 US8653091, 12 P2X purinoceptor 3 Homo sapiens 88 US Patent 10.7270/Q20G3HTJ aid1800362 US8653091 Wei, Z; Kincaid, J; Kelly, MG; O'Mahony, DJ; Kaub, C Evotec AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118117 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118117&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 25033091 199998501 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 244274 CCc1ccc(cc1)C(C)Nc1ncnc2CCN(Cc12)c1ccc(C)cn1 InChI=1S/C23H27N5/c1-4-18-6-8-19(9-7-18)17(3)27-23-20-14-28(12-11-21(20)25-15-26-23)22-10-5-16(2)13-24-22/h5-10,13,15,17H,4,11-12,14H2,1-3H3,(H,25,26,27) WTEFMFHLHIXCDB-UHFFFAOYSA-N 118118 US8653091, 13 P2X purinoceptor 3 Homo sapiens 603 US Patent 10.7270/Q20G3HTJ aid1800362 US8653091 Wei, Z; Kincaid, J; Kelly, MG; O'Mahony, DJ; Kaub, C Evotec AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118118 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118118&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 25033092 199998502 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 244275 COc1ccccc1C(C)Nc1ncnc2CCN(Cc12)c1ccc(C)cn1 InChI=1S/C22H25N5O/c1-15-8-9-21(23-12-15)27-11-10-19-18(13-27)22(25-14-24-19)26-16(2)17-6-4-5-7-20(17)28-3/h4-9,12,14,16H,10-11,13H2,1-3H3,(H,24,25,26) KCOZDLJGLHTDIQ-UHFFFAOYSA-N 118119 US8653091, 14 P2X purinoceptor 3 Homo sapiens 137 US Patent 10.7270/Q20G3HTJ aid1800362 US8653091 Wei, Z; Kincaid, J; Kelly, MG; O'Mahony, DJ; Kaub, C Evotec AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118119 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118119&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 25033175 199998503 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 244276 CC(Nc1ncnc2CCN(Cc12)c1ccc(C)cn1)c1ccccc1Cl InChI=1S/C21H22ClN5/c1-14-7-8-20(23-11-14)27-10-9-19-17(12-27)21(25-13-24-19)26-15(2)16-5-3-4-6-18(16)22/h3-8,11,13,15H,9-10,12H2,1-2H3,(H,24,25,26) YCUDKFILFQRHLI-UHFFFAOYSA-N 118120 US8653091, 15 P2X purinoceptor 3 Homo sapiens 125 US Patent 10.7270/Q20G3HTJ aid1800362 US8653091 Wei, Z; Kincaid, J; Kelly, MG; O'Mahony, DJ; Kaub, C Evotec AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118120 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118120&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 25033176 199998504 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 244277 CC(Nc1ncnc2CCN(Cc12)c1ccc(C)cn1)c1cccc(Cl)c1 InChI=1S/C21H22ClN5/c1-14-6-7-20(23-11-14)27-9-8-19-18(12-27)21(25-13-24-19)26-15(2)16-4-3-5-17(22)10-16/h3-7,10-11,13,15H,8-9,12H2,1-2H3,(H,24,25,26) IUPSCNROFMBCEW-UHFFFAOYSA-N 118121 US8653091, 16 P2X purinoceptor 3 Homo sapiens 119 US Patent 10.7270/Q20G3HTJ aid1800362 US8653091 Wei, Z; Kincaid, J; Kelly, MG; O'Mahony, DJ; Kaub, C Evotec AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118121 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118121&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 25033177 199998505 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 244278 CC(Nc1ncnc2CCN(Cc12)c1ccc(C)cn1)c1cc(F)cc(F)c1 InChI=1S/C21H21F2N5/c1-13-3-4-20(24-10-13)28-6-5-19-18(11-28)21(26-12-25-19)27-14(2)15-7-16(22)9-17(23)8-15/h3-4,7-10,12,14H,5-6,11H2,1-2H3,(H,25,26,27) STMMULZVHSKPDR-UHFFFAOYSA-N 118122 US8653091, 17 P2X purinoceptor 3 Homo sapiens 52 US Patent 10.7270/Q20G3HTJ aid1800362 US8653091 Wei, Z; Kincaid, J; Kelly, MG; O'Mahony, DJ; Kaub, C Evotec AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118122 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118122&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 25033178 199998506 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 244279 CC(Nc1ncnc2CCN(Cc12)c1ccc(C)cn1)c1ccc(F)cc1F InChI=1S/C21H21F2N5/c1-13-3-6-20(24-10-13)28-8-7-19-17(11-28)21(26-12-25-19)27-14(2)16-5-4-15(22)9-18(16)23/h3-6,9-10,12,14H,7-8,11H2,1-2H3,(H,25,26,27) HUNKNRMFRKNUAR-UHFFFAOYSA-N 118123 US8653091, 18 P2X purinoceptor 3 Homo sapiens 50 US Patent 10.7270/Q20G3HTJ aid1800362 US8653091 Wei, Z; Kincaid, J; Kelly, MG; O'Mahony, DJ; Kaub, C Evotec AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118123 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118123&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 25033179 199998507 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 244280 COc1ccc(cc1F)C(C)Nc1ncnc2CCN(Cc12)c1ccc(C)cn1 InChI=1S/C22H24FN5O/c1-14-4-7-21(24-11-14)28-9-8-19-17(12-28)22(26-13-25-19)27-15(2)16-5-6-20(29-3)18(23)10-16/h4-7,10-11,13,15H,8-9,12H2,1-3H3,(H,25,26,27) DQEIWRKPVLQBJW-UHFFFAOYSA-N 118126 US8653091, 21 P2X purinoceptor 3 Homo sapiens 80 US Patent 10.7270/Q20G3HTJ aid1800362 US8653091 Wei, Z; Kincaid, J; Kelly, MG; O'Mahony, DJ; Kaub, C Evotec AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118126 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118126&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 25033251 199998510 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 244281 CC(Nc1ncnc2CCN(Cc12)c1ccc(C)cn1)c1ccc(cc1)C(F)(F)F InChI=1S/C22H22F3N5/c1-14-3-8-20(26-11-14)30-10-9-19-18(12-30)21(28-13-27-19)29-15(2)16-4-6-17(7-5-16)22(23,24)25/h3-8,11,13,15H,9-10,12H2,1-2H3,(H,27,28,29) KPQNVEFDANSNEJ-UHFFFAOYSA-N 118131 US8653091, 26 P2X purinoceptor 3 Homo sapiens 245 US Patent 10.7270/Q20G3HTJ aid1800362 US8653091 Wei, Z; Kincaid, J; Kelly, MG; O'Mahony, DJ; Kaub, C Evotec AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118131 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118131&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 25033256 199998515 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 244282 CC(Nc1ncnc2CCN(Cc12)c1ccc(C)cn1)c1ccc(Cl)cc1Cl InChI=1S/C21H21Cl2N5/c1-13-3-6-20(24-10-13)28-8-7-19-17(11-28)21(26-12-25-19)27-14(2)16-5-4-15(22)9-18(16)23/h3-6,9-10,12,14H,7-8,11H2,1-2H3,(H,25,26,27) CLBSVPYCZLWSCF-UHFFFAOYSA-N 118132 US8653091, 27 P2X purinoceptor 3 Homo sapiens 415 US Patent 10.7270/Q20G3HTJ aid1800362 US8653091 Wei, Z; Kincaid, J; Kelly, MG; O'Mahony, DJ; Kaub, C Evotec AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118132 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118132&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 25033331 199998516 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 244283 CC(Nc1ncnc2CCN(Cc12)c1ccc(C)cn1)c1ccc(Br)cc1 InChI=1S/C21H22BrN5/c1-14-3-8-20(23-11-14)27-10-9-19-18(12-27)21(25-13-24-19)26-15(2)16-4-6-17(22)7-5-16/h3-8,11,13,15H,9-10,12H2,1-2H3,(H,24,25,26) YVOGFFAHHJCXSZ-UHFFFAOYSA-N 118133 US8653091, 28 P2X purinoceptor 3 Homo sapiens 212 US Patent 10.7270/Q20G3HTJ aid1800362 US8653091 Wei, Z; Kincaid, J; Kelly, MG; O'Mahony, DJ; Kaub, C Evotec AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118133 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118133&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 25033332 199998517 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 244284 Cc1ccc(nc1)N1CCc2ncnc(NC(CCO)c3ccccc3)c2C1 InChI=1S/C22H25N5O/c1-16-7-8-21(23-13-16)27-11-9-20-18(14-27)22(25-15-24-20)26-19(10-12-28)17-5-3-2-4-6-17/h2-8,13,15,19,28H,9-12,14H2,1H3,(H,24,25,26) DMPAJVSIPCPEOU-UHFFFAOYSA-N 118137 US8653091, 32 P2X purinoceptor 3 Homo sapiens 143 US Patent 10.7270/Q20G3HTJ aid1800362 US8653091 Wei, Z; Kincaid, J; Kelly, MG; O'Mahony, DJ; Kaub, C Evotec AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118137 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118137&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 25033336 199998521 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 244285 C[C@@H](Nc1ncnc2CCN(Cc12)c1ccc(C)cn1)c1ccc(C)cc1 InChI=1S/C22H25N5/c1-15-4-7-18(8-5-15)17(3)26-22-19-13-27(11-10-20(19)24-14-25-22)21-9-6-16(2)12-23-21/h4-9,12,14,17H,10-11,13H2,1-3H3,(H,24,25,26)/t17-/m1/s1 JSQPMXXGCBUZST-QGZVFWFLSA-N 118139 US8653091, 34 P2X purinoceptor 3 Homo sapiens 47 US Patent 10.7270/Q20G3HTJ aid1800362 US8653091 Wei, Z; Kincaid, J; Kelly, MG; O'Mahony, DJ; Kaub, C Evotec AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118139 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118139&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 25033409 199998523 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 244286 CCC(Nc1ncnc2CCN(Cc12)c1ccc(C)cn1)c1ccccc1 InChI=1S/C22H25N5/c1-3-19(17-7-5-4-6-8-17)26-22-18-14-27(12-11-20(18)24-15-25-22)21-10-9-16(2)13-23-21/h4-10,13,15,19H,3,11-12,14H2,1-2H3,(H,24,25,26) XVVMIRNQEFEULE-UHFFFAOYSA-N 118141 US8653091, 36 P2X purinoceptor 3 Homo sapiens 397 US Patent 10.7270/Q20G3HTJ aid1800362 US8653091 Wei, Z; Kincaid, J; Kelly, MG; O'Mahony, DJ; Kaub, C Evotec AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118141 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118141&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 25033411 199998525 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 244287 Cc1ccc(nc1)N1CCc2ncnc(N[C@H](CO)c3ccccc3)c2C1 InChI=1S/C21H23N5O/c1-15-7-8-20(22-11-15)26-10-9-18-17(12-26)21(24-14-23-18)25-19(13-27)16-5-3-2-4-6-16/h2-8,11,14,19,27H,9-10,12-13H2,1H3,(H,23,24,25)/t19-/m1/s1 RKPAFGOLZJQTPL-LJQANCHMSA-N 118142 US8653091, 37 P2X purinoceptor 3 Homo sapiens 161 US Patent 10.7270/Q20G3HTJ aid1800362 US8653091 Wei, Z; Kincaid, J; Kelly, MG; O'Mahony, DJ; Kaub, C Evotec AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118142 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118142&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 25033412 199998526 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 244288 CC(Nc1ncnc2CCN(Cc12)c1ccc(C)cn1)c1ccc(Cl)c(F)c1 InChI=1S/C21H21ClFN5/c1-13-3-6-20(24-10-13)28-8-7-19-16(11-28)21(26-12-25-19)27-14(2)15-4-5-17(22)18(23)9-15/h3-6,9-10,12,14H,7-8,11H2,1-2H3,(H,25,26,27) CNUGQOFQIIDDCR-UHFFFAOYSA-N 118144 US8653091, 39 P2X purinoceptor 3 Homo sapiens 43 US Patent 10.7270/Q20G3HTJ aid1800362 US8653091 Wei, Z; Kincaid, J; Kelly, MG; O'Mahony, DJ; Kaub, C Evotec AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118144 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118144&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 25033414 199998528 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 244289 C[C@@H](Nc1ncnc2CCN(Cc12)c1ccc(Cl)cn1)c1ccc(Cl)cc1 InChI=1S/C20H19Cl2N5/c1-13(14-2-4-15(21)5-3-14)26-20-17-11-27(9-8-18(17)24-12-25-20)19-7-6-16(22)10-23-19/h2-7,10,12-13H,8-9,11H2,1H3,(H,24,25,26)/t13-/m1/s1 CJYBSPSAYUVDMV-CYBMUJFWSA-N 118145 US8653091, 40 P2X purinoceptor 3 Homo sapiens 344 US Patent 10.7270/Q20G3HTJ aid1800362 US8653091 Wei, Z; Kincaid, J; Kelly, MG; O'Mahony, DJ; Kaub, C Evotec AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118145 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118145&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 25033493 199998529 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 244290 CC[C@@H](Nc1ncnc2CCN(Cc12)c1ccc(C)cn1)c1ccccc1 InChI=1S/C22H25N5/c1-3-19(17-7-5-4-6-8-17)26-22-18-14-27(12-11-20(18)24-15-25-22)21-10-9-16(2)13-23-21/h4-10,13,15,19H,3,11-12,14H2,1-2H3,(H,24,25,26)/t19-/m1/s1 XVVMIRNQEFEULE-LJQANCHMSA-N 118147 US8653091, 42 P2X purinoceptor 3 Homo sapiens 408 US Patent 10.7270/Q20G3HTJ aid1800362 US8653091 Wei, Z; Kincaid, J; Kelly, MG; O'Mahony, DJ; Kaub, C Evotec AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118147 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118147&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 25033495 199998531 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 244291 COc1ccc(cc1)[C@@H](C)Nc1ncnc2CCN(Cc12)c1ccc(C)cn1 InChI=1S/C22H25N5O/c1-15-4-9-21(23-12-15)27-11-10-20-19(13-27)22(25-14-24-20)26-16(2)17-5-7-18(28-3)8-6-17/h4-9,12,14,16H,10-11,13H2,1-3H3,(H,24,25,26)/t16-/m1/s1 YGIOSPPWRLVBJP-MRXNPFEDSA-N 118148 US8653091, 43 P2X purinoceptor 3 Homo sapiens 181 US Patent 10.7270/Q20G3HTJ aid1800362 US8653091 Wei, Z; Kincaid, J; Kelly, MG; O'Mahony, DJ; Kaub, C Evotec AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118148 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118148&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 25033496 199998532 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 244292 CC[C@H](Nc1ncnc2CCN(Cc12)c1ccc(C)cn1)c1ccccc1 InChI=1S/C22H25N5/c1-3-19(17-7-5-4-6-8-17)26-22-18-14-27(12-11-20(18)24-15-25-22)21-10-9-16(2)13-23-21/h4-10,13,15,19H,3,11-12,14H2,1-2H3,(H,24,25,26)/t19-/m0/s1 XVVMIRNQEFEULE-IBGZPJMESA-N 118150 US8653091, 45 P2X purinoceptor 3 Homo sapiens >10000 US Patent 10.7270/Q20G3HTJ aid1800362 US8653091 Wei, Z; Kincaid, J; Kelly, MG; O'Mahony, DJ; Kaub, C Evotec AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118150 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118150&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 25033498 199998534 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 244293 COc1cccc(c1)[C@@H](C)Nc1ncnc2CCN(Cc12)c1ccc(C)cn1 InChI=1S/C22H25N5O/c1-15-7-8-21(23-12-15)27-10-9-20-19(13-27)22(25-14-24-20)26-16(2)17-5-4-6-18(11-17)28-3/h4-8,11-12,14,16H,9-10,13H2,1-3H3,(H,24,25,26)/t16-/m1/s1 BSHIAFMHMKJSPC-MRXNPFEDSA-N 118152 US8653091, 47 P2X purinoceptor 3 Homo sapiens 21 US Patent 10.7270/Q20G3HTJ aid1800362 US8653091 Wei, Z; Kincaid, J; Kelly, MG; O'Mahony, DJ; Kaub, C Evotec AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118152 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118152&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 25033573 199998536 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 244294 C[C@@H](Nc1ncnc2CCN(Cc12)c1ccc(C)cn1)c1ccc(F)cc1 InChI=1S/C21H22FN5/c1-14-3-8-20(23-11-14)27-10-9-19-18(12-27)21(25-13-24-19)26-15(2)16-4-6-17(22)7-5-16/h3-8,11,13,15H,9-10,12H2,1-2H3,(H,24,25,26)/t15-/m1/s1 DUPYPBQTFOKCSC-OAHLLOKOSA-N 118154 US8653091, 49 P2X purinoceptor 3 Homo sapiens 19 US Patent 10.7270/Q20G3HTJ aid1800362 US8653091 Wei, Z; Kincaid, J; Kelly, MG; O'Mahony, DJ; Kaub, C Evotec AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118154 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118154&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 25033097 199998538 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 244295 C[C@@H](Nc1ncnc2CCN(Cc12)c1ccc(C)cn1)c1ccc(nc1)C(F)(F)F InChI=1S/C21H21F3N6/c1-13-3-6-19(26-9-13)30-8-7-17-16(11-30)20(28-12-27-17)29-14(2)15-4-5-18(25-10-15)21(22,23)24/h3-6,9-10,12,14H,7-8,11H2,1-2H3,(H,27,28,29)/t14-/m1/s1 ICLOKAIXSUXTKZ-CQSZACIVSA-N 118155 US8653091, 50 P2X purinoceptor 3 Homo sapiens 15 US Patent 10.7270/Q20G3HTJ aid1800362 US8653091 Wei, Z; Kincaid, J; Kelly, MG; O'Mahony, DJ; Kaub, C Evotec AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118155 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118155&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 25033574 199998539 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 244296 C[C@H](Nc1ncnc2CCN(Cc12)c1ccc(Cl)cn1)c1ccc(nc1)C(F)(F)F InChI=1S/C20H18ClF3N6/c1-12(13-2-4-17(25-8-13)20(22,23)24)29-19-15-10-30(7-6-16(15)27-11-28-19)18-5-3-14(21)9-26-18/h2-5,8-9,11-12H,6-7,10H2,1H3,(H,27,28,29)/t12-/m0/s1 VCVJHUNWPOOPQN-LBPRGKRZSA-N 118156 US8653091, 51 P2X purinoceptor 3 Homo sapiens >10000 US Patent 10.7270/Q20G3HTJ aid1800362 US8653091 Wei, Z; Kincaid, J; Kelly, MG; O'Mahony, DJ; Kaub, C Evotec AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118156 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118156&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 25033575 199998540 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 244297 C[C@@H](Nc1ncnc2CCN(Cc12)c1ccc(Cl)cn1)c1ccc(nc1)C(F)(F)F InChI=1S/C20H18ClF3N6/c1-12(13-2-4-17(25-8-13)20(22,23)24)29-19-15-10-30(7-6-16(15)27-11-28-19)18-5-3-14(21)9-26-18/h2-5,8-9,11-12H,6-7,10H2,1H3,(H,27,28,29)/t12-/m1/s1 VCVJHUNWPOOPQN-GFCCVEGCSA-N 118157 US8653091, 52 P2X purinoceptor 3 Homo sapiens 33 US Patent 10.7270/Q20G3HTJ aid1800362 US8653091 Wei, Z; Kincaid, J; Kelly, MG; O'Mahony, DJ; Kaub, C Evotec AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118157 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118157&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 25033576 199998541 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 244298 FC(F)(F)c1ccc(cn1)[C@H](Nc1ncnc2CCN(Cc12)c1ccc(Cl)cn1)C1CC1 InChI=1S/C22H20ClF3N6/c23-15-4-6-19(28-10-15)32-8-7-17-16(11-32)21(30-12-29-17)31-20(13-1-2-13)14-3-5-18(27-9-14)22(24,25)26/h3-6,9-10,12-13,20H,1-2,7-8,11H2,(H,29,30,31)/t20-/m1/s1 CMEYRTUYGFNHBD-HXUWFJFHSA-N 118158 US8653091, 53 P2X purinoceptor 3 Homo sapiens 3555 US Patent 10.7270/Q20G3HTJ aid1800362 US8653091 Wei, Z; Kincaid, J; Kelly, MG; O'Mahony, DJ; Kaub, C Evotec AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118158 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118158&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 25033577 199998542 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 244299 FC(F)(F)c1ccc(cn1)[C@@H](Nc1ncnc2CCN(Cc12)c1ccc(Cl)cn1)C1CC1 InChI=1S/C22H20ClF3N6/c23-15-4-6-19(28-10-15)32-8-7-17-16(11-32)21(30-12-29-17)31-20(13-1-2-13)14-3-5-18(27-9-14)22(24,25)26/h3-6,9-10,12-13,20H,1-2,7-8,11H2,(H,29,30,31)/t20-/m0/s1 CMEYRTUYGFNHBD-FQEVSTJZSA-N 118159 US8653091, 54 P2X purinoceptor 3 Homo sapiens >10000 US Patent 10.7270/Q20G3HTJ aid1800362 US8653091 Wei, Z; Kincaid, J; Kelly, MG; O'Mahony, DJ; Kaub, C Evotec AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118159 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118159&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 25033578 199998543 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 244300 Cc1ccc(nc1)N1CCc2ncnc(N[C@H](CO)c3ccc(cc3)C(F)(F)F)c2C1 InChI=1S/C22H22F3N5O/c1-14-2-7-20(26-10-14)30-9-8-18-17(11-30)21(28-13-27-18)29-19(12-31)15-3-5-16(6-4-15)22(23,24)25/h2-7,10,13,19,31H,8-9,11-12H2,1H3,(H,27,28,29)/t19-/m1/s1 XTUGYSDHPHABIN-LJQANCHMSA-N 118160 US8653091, 55 P2X purinoceptor 3 Homo sapiens 158 US Patent 10.7270/Q20G3HTJ aid1800362 US8653091 Wei, Z; Kincaid, J; Kelly, MG; O'Mahony, DJ; Kaub, C Evotec AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118160 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118160&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 25032423 199998544 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 244301 Cc1ccc(nc1)N1CCc2ncnc(NC(CCO)c3ccc(nc3)C(F)(F)F)c2C1 InChI=1S/C22H23F3N6O/c1-14-2-5-20(27-10-14)31-8-6-18-16(12-31)21(29-13-28-18)30-17(7-9-32)15-3-4-19(26-11-15)22(23,24)25/h2-5,10-11,13,17,32H,6-9,12H2,1H3,(H,28,29,30) JYXGOVPRQNIYKV-UHFFFAOYSA-N 118161 US8653091, 56 P2X purinoceptor 3 Homo sapiens 67 US Patent 10.7270/Q20G3HTJ aid1800362 US8653091 Wei, Z; Kincaid, J; Kelly, MG; O'Mahony, DJ; Kaub, C Evotec AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118161 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118161&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 25032346 199998545 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 244302 COc1ccc(cn1)[C@@H](CCO)Nc1ncnc2CCN(Cc12)c1ccc(Cl)cn1 InChI=1S/C21H23ClN6O2/c1-30-20-5-2-14(10-24-20)17(7-9-29)27-21-16-12-28(8-6-18(16)25-13-26-21)19-4-3-15(22)11-23-19/h2-5,10-11,13,17,29H,6-9,12H2,1H3,(H,25,26,27)/t17-/m1/s1 SGUGDZUWFAUPNY-QGZVFWFLSA-N 118162 US8653091, 57 P2X purinoceptor 3 Homo sapiens 103 US Patent 10.7270/Q20G3HTJ aid1800362 US8653091 Wei, Z; Kincaid, J; Kelly, MG; O'Mahony, DJ; Kaub, C Evotec AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118162 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118162&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 25032347 199998546 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 244303 COc1ccc(cn1)[C@@H](CCO)Nc1ncnc2CCN(Cc12)c1ccc(C)cn1 InChI=1S/C22H26N6O2/c1-15-3-5-20(23-11-15)28-9-7-19-17(13-28)22(26-14-25-19)27-18(8-10-29)16-4-6-21(30-2)24-12-16/h3-6,11-12,14,18,29H,7-10,13H2,1-2H3,(H,25,26,27)/t18-/m1/s1 PUIPLPMBTAVSBG-GOSISDBHSA-N 118163 US8653091, 58 P2X purinoceptor 3 Homo sapiens 29 US Patent 10.7270/Q20G3HTJ aid1800362 US8653091 Wei, Z; Kincaid, J; Kelly, MG; O'Mahony, DJ; Kaub, C Evotec AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118163 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118163&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 25032348 199998547 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 244304 COc1ccc(cn1)[C@@H](CO)Nc1ncnc2CCN(Cc12)c1ccc(Cl)cn1 InChI=1S/C20H21ClN6O2/c1-29-19-5-2-13(8-23-19)17(11-28)26-20-15-10-27(7-6-16(15)24-12-25-20)18-4-3-14(21)9-22-18/h2-5,8-9,12,17,28H,6-7,10-11H2,1H3,(H,24,25,26)/t17-/m1/s1 WPBBTBJCOJRQNE-QGZVFWFLSA-N 118164 US8653091, 59 P2X purinoceptor 3 Homo sapiens 90 US Patent 10.7270/Q20G3HTJ aid1800362 US8653091 Wei, Z; Kincaid, J; Kelly, MG; O'Mahony, DJ; Kaub, C Evotec AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118164 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118164&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 25032349 199998548 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 244305 COc1ccc(cn1)[C@@H](CO)Nc1ncnc2CCN(Cc12)c1ccc(C)cn1 InChI=1S/C21H24N6O2/c1-14-3-5-19(22-9-14)27-8-7-17-16(11-27)21(25-13-24-17)26-18(12-28)15-4-6-20(29-2)23-10-15/h3-6,9-10,13,18,28H,7-8,11-12H2,1-2H3,(H,24,25,26)/t18-/m1/s1 COHPLRFPNJNJIX-GOSISDBHSA-N 118165 US8653091, 60 P2X purinoceptor 3 Homo sapiens 27 US Patent 10.7270/Q20G3HTJ aid1800362 US8653091 Wei, Z; Kincaid, J; Kelly, MG; O'Mahony, DJ; Kaub, C Evotec AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118165 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118165&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 25032350 199998549 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 244306 Cc1ccc(nc1)N1CCc2ncnc(N[C@H](CCO)c3ccc(C)nc3)c2C1 InChI=1S/C22H26N6O/c1-15-3-6-21(24-11-15)28-9-7-20-18(13-28)22(26-14-25-20)27-19(8-10-29)17-5-4-16(2)23-12-17/h3-6,11-12,14,19,29H,7-10,13H2,1-2H3,(H,25,26,27)/t19-/m1/s1 SSNDZSZPTDFBHC-LJQANCHMSA-N 118166 US8653091, 61 P2X purinoceptor 3 Homo sapiens 28 US Patent 10.7270/Q20G3HTJ aid1800362 US8653091 Wei, Z; Kincaid, J; Kelly, MG; O'Mahony, DJ; Kaub, C Evotec AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118166 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118166&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 25032351 199998550 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 244307 Cc1ccc(nc1)N1CCc2ncnc(NC(CO)c3cccnc3)c2C1 InChI=1S/C20H22N6O/c1-14-4-5-19(22-9-14)26-8-6-17-16(11-26)20(24-13-23-17)25-18(12-27)15-3-2-7-21-10-15/h2-5,7,9-10,13,18,27H,6,8,11-12H2,1H3,(H,23,24,25) DTQUOODAYMQTHN-UHFFFAOYSA-N 118167 US8653091, 62 P2X purinoceptor 3 Homo sapiens 272 US Patent 10.7270/Q20G3HTJ aid1800362 US8653091 Wei, Z; Kincaid, J; Kelly, MG; O'Mahony, DJ; Kaub, C Evotec AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118167 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118167&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 25032424 199998551 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 244308 Cc1ccc(nc1)N1CCc2ncnc(N[C@H](CCO)c3ccc(nc3)C(F)(F)F)c2C1 InChI=1S/C22H23F3N6O/c1-14-2-5-20(27-10-14)31-8-6-18-16(12-31)21(29-13-28-18)30-17(7-9-32)15-3-4-19(26-11-15)22(23,24)25/h2-5,10-11,13,17,32H,6-9,12H2,1H3,(H,28,29,30)/t17-/m1/s1 JYXGOVPRQNIYKV-QGZVFWFLSA-N 118168 US8653091, 63 P2X purinoceptor 3 Homo sapiens 24 US Patent 10.7270/Q20G3HTJ aid1800362 US8653091 Wei, Z; Kincaid, J; Kelly, MG; O'Mahony, DJ; Kaub, C Evotec AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118168 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118168&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 25032425 199998552 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 244309 C[C@@H](Nc1ncnc2CCN(Cc12)c1ccc(C)cn1)c1cnc(C)nc1 InChI=1S/C20H23N7/c1-13-4-5-19(23-8-13)27-7-6-18-17(11-27)20(25-12-24-18)26-14(2)16-9-21-15(3)22-10-16/h4-5,8-10,12,14H,6-7,11H2,1-3H3,(H,24,25,26)/t14-/m1/s1 XNAFMMCWOUXFDU-CQSZACIVSA-N 118169 US8653091, 64 P2X purinoceptor 3 Homo sapiens 17 US Patent 10.7270/Q20G3HTJ aid1800362 US8653091 Wei, Z; Kincaid, J; Kelly, MG; O'Mahony, DJ; Kaub, C Evotec AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118169 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118169&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 24995216 199998553 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330863 CC(C)n1c(=O)nc(Nc2cccc(c2)C(F)(F)F)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C20H18ClF3N4O2/c1-12(2)28-18(29)26-17(25-16-5-3-4-14(10-16)20(22,23)24)27(19(28)30)11-13-6-8-15(21)9-7-13/h3-10,12H,11H2,1-2H3,(H,25,26,29) UUGKLNMQRWYVRO-UHFFFAOYSA-N 183070 US9150546, I-020::US9688643, I-020::US9718790, I-0020 P2X purinoceptor 3 Homo sapiens 389 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183070 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183070&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821112 313634470 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330864 CC(C)n1c(=O)nc(Nc2cccc(c2)C(F)(F)F)n(Cc2ccc(C)cc2)c1=O InChI=1S/C21H21F3N4O2/c1-13(2)28-19(29)26-18(25-17-6-4-5-16(11-17)21(22,23)24)27(20(28)30)12-15-9-7-14(3)8-10-15/h4-11,13H,12H2,1-3H3,(H,25,26,29) YOKVDDNYLFEVNF-UHFFFAOYSA-N 183071 US9150546, I-021::US9688643, I-021::US9718790, I-0021 P2X purinoceptor 3 Homo sapiens 197 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183071 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183071&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 75237521 313634471 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330865 CCCCn1c(=O)nc(Nc2cccc(c2)C(F)(F)F)n(Cc2ccc(C)cc2)c1=O InChI=1S/C22H23F3N4O2/c1-3-4-12-28-20(30)27-19(26-18-7-5-6-17(13-18)22(23,24)25)29(21(28)31)14-16-10-8-15(2)9-11-16/h5-11,13H,3-4,12,14H2,1-2H3,(H,26,27,30) CSTQVHSGLNKRJV-UHFFFAOYSA-N 183072 US9150546, I-029::US9688643, I-029::US9718790, I-0029 P2X purinoceptor 3 Homo sapiens 595 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183072 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183072&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 75237553 313634472 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330866 Cc1ccc(Cn2c(Nc3cccc(c3)C(F)(F)F)nc(=O)n(c2=O)C(C)(C)C)cc1 InChI=1S/C22H23F3N4O2/c1-14-8-10-15(11-9-14)13-28-18(27-19(30)29(20(28)31)21(2,3)4)26-17-7-5-6-16(12-17)22(23,24)25/h5-12H,13H2,1-4H3,(H,26,27,30) GSQTVLOBZSWCFK-UHFFFAOYSA-N 183073 US9150546, I-097::US9688643, I-097::US9718790, I-0097 P2X purinoceptor 3 Homo sapiens 505 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183073 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183073&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821135 313634473 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330867 CC(C)n1c(=O)nc(Nc2ccc(Oc3ccccc3)cc2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C26H26N4O3/c1-18(2)30-25(31)28-24(29(26(30)32)17-20-11-9-19(3)10-12-20)27-21-13-15-23(16-14-21)33-22-7-5-4-6-8-22/h4-16,18H,17H2,1-3H3,(H,27,28,31) WTXITHIOEDHEDI-UHFFFAOYSA-N 183074 US9150546, I-116::US9688643, I-116::US9718790, I-0116 P2X purinoceptor 3 Homo sapiens 484 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183074 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183074&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821393 313634474 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330868 CC(C)n1c(=O)nc(Nc2cccc(Cl)c2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C20H21ClN4O2/c1-13(2)25-19(26)23-18(22-17-6-4-5-16(21)11-17)24(20(25)27)12-15-9-7-14(3)8-10-15/h4-11,13H,12H2,1-3H3,(H,22,23,26) JDTYNPPCONPDCJ-UHFFFAOYSA-N 183075 US9150546, I-117::US9688643, I-117::US9718790, I-0117 P2X purinoceptor 3 Homo sapiens 387 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183075 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183075&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76820975 313634475 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330869 CSc1cccc(Nc2nc(=O)n(C(C)C)c(=O)n2Cc2ccc(C)cc2)c1 InChI=1S/C21H24N4O2S/c1-14(2)25-20(26)23-19(22-17-6-5-7-18(12-17)28-4)24(21(25)27)13-16-10-8-15(3)9-11-16/h5-12,14H,13H2,1-4H3,(H,22,23,26) SERAWUWTGODSSL-UHFFFAOYSA-N 183076 US9150546, I-118::US9688643, I-118::US9718790, I-0118 P2X purinoceptor 3 Homo sapiens 231 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183076 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183076&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 75237596 313634476 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330870 CC(C)Oc1ccc(Nc2nc(=O)n(C(C)C)c(=O)n2Cc2ccc(C)cc2)cc1 InChI=1S/C23H28N4O3/c1-15(2)27-22(28)25-21(24-19-10-12-20(13-11-19)30-16(3)4)26(23(27)29)14-18-8-6-17(5)7-9-18/h6-13,15-16H,14H2,1-5H3,(H,24,25,28) SFHXKQUAZHFZDZ-UHFFFAOYSA-N 183077 US9150546, I-121::US9688643, I-121::US9718790, I-0121 P2X purinoceptor 3 Homo sapiens 246 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183077 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183077&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821026 313634477 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330871 CC(C)n1c(=O)nc(Nc2ccc3[nH]ccc3c2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C22H23N5O2/c1-14(2)27-21(28)25-20(24-18-8-9-19-17(12-18)10-11-23-19)26(22(27)29)13-16-6-4-15(3)5-7-16/h4-12,14,23H,13H2,1-3H3,(H,24,25,28) VFEADJKRJBHYRS-UHFFFAOYSA-N 183078 US9150546, I-123::US9688643, I-123::US9718790, I-0123 P2X purinoceptor 3 Homo sapiens 815 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183078 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183078&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 75237597 313634478 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330872 CC(C)n1c(=O)nc(Nc2cccc(c2)C(F)(F)F)n(Cc2ccc(F)cc2)c1=O InChI=1S/C20H18F4N4O2/c1-12(2)28-18(29)26-17(25-16-5-3-4-14(10-16)20(22,23)24)27(19(28)30)11-13-6-8-15(21)9-7-13/h3-10,12H,11H2,1-2H3,(H,25,26,29) MSMVJAKQZYUCKV-UHFFFAOYSA-N 183079 US9150546, I-126::US9688643, I-126::US9718790, I-0126 P2X purinoceptor 3 Homo sapiens 689 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183079 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183079&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821386 313634479 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330873 CC(C)n1c(=O)nc(Nc2ccc(Oc3ccccc3)cc2)n(Cc2ccc(F)cc2)c1=O InChI=1S/C25H23FN4O3/c1-17(2)30-24(31)28-23(29(25(30)32)16-18-8-10-19(26)11-9-18)27-20-12-14-22(15-13-20)33-21-6-4-3-5-7-21/h3-15,17H,16H2,1-2H3,(H,27,28,31) CNSNAAGHAOMOPM-UHFFFAOYSA-N 183080 US9150546, I-128::US9688643, I-128::US9718790, I-0128 P2X purinoceptor 3 Homo sapiens 840 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183080 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183080&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821421 313634480 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330874 CSc1cccc(Nc2nc(=O)n(C(C)C)c(=O)n2Cc2ccc(F)cc2)c1 InChI=1S/C20H21FN4O2S/c1-13(2)25-19(26)23-18(22-16-5-4-6-17(11-16)28-3)24(20(25)27)12-14-7-9-15(21)10-8-14/h4-11,13H,12H2,1-3H3,(H,22,23,26) KUHNCTZRZIHMNZ-UHFFFAOYSA-N 183081 US9150546, I-130::US9688643, I-130::US9718790, I-0130 P2X purinoceptor 3 Homo sapiens 953 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183081 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183081&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821143 313634481 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330875 CC(C)Oc1ccc(Nc2nc(=O)n(C(C)C)c(=O)n2Cc2ccc(F)cc2)cc1 InChI=1S/C22H25FN4O3/c1-14(2)27-21(28)25-20(24-18-9-11-19(12-10-18)30-15(3)4)26(22(27)29)13-16-5-7-17(23)8-6-16/h5-12,14-15H,13H2,1-4H3,(H,24,25,28) CFGDBJCENZPXFT-UHFFFAOYSA-N 183082 US9150546, I-133::US9688643, I-133::US9718790, I-0133 P2X purinoceptor 3 Homo sapiens 339 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183082 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183082&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821219 313634482 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330876 CCn1c(=O)nc(Nc2cccc(c2)C(F)(F)F)n(Cc2ccc(F)cc2)c1=O InChI=1S/C19H16F4N4O2/c1-2-26-17(28)25-16(24-15-5-3-4-13(10-15)19(21,22)23)27(18(26)29)11-12-6-8-14(20)9-7-12/h3-10H,2,11H2,1H3,(H,24,25,28) VQUSPBTZXROEJD-UHFFFAOYSA-N 183083 US9150546, I-138::US9688643, I-138::US9718790, I-0138 P2X purinoceptor 3 Homo sapiens 619 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183083 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183083&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821341 313634483 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330877 CCn1c(=O)nc(Nc2ccc(Oc3ccccc3)cc2)n(Cc2ccc(F)cc2)c1=O InChI=1S/C24H21FN4O3/c1-2-28-23(30)27-22(29(24(28)31)16-17-8-10-18(25)11-9-17)26-19-12-14-21(15-13-19)32-20-6-4-3-5-7-20/h3-15H,2,16H2,1H3,(H,26,27,30) XYDHNFAHHWQXIT-UHFFFAOYSA-N 183084 US9150546, I-141::US9688643, I-141::US9718790, I-0141 P2X purinoceptor 3 Homo sapiens 685 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183084 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183084&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76820951 313634484 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330878 CC(C)n1c(=O)nc(Nc2cccc(c2)C(F)(F)F)n(Cc2ccc(Cl)cn2)c1=O InChI=1S/C19H17ClF3N5O2/c1-11(2)28-17(29)26-16(25-14-5-3-4-12(8-14)19(21,22)23)27(18(28)30)10-15-7-6-13(20)9-24-15/h3-9,11H,10H2,1-2H3,(H,25,26,29) YBSHZIGUKUOWCU-UHFFFAOYSA-N 183085 US9150546, I-162::US9688643, I-162::US9718790, I-0162 P2X purinoceptor 3 Homo sapiens 379 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183085 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183085&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821366 313634485 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330879 CC(C)n1c(=O)nc(Nc2ccc(Oc3ccccc3)cc2)n(Cc2ccc(Cl)cn2)c1=O InChI=1S/C24H22ClN5O3/c1-16(2)30-23(31)28-22(29(24(30)32)15-19-9-8-17(25)14-26-19)27-18-10-12-21(13-11-18)33-20-6-4-3-5-7-20/h3-14,16H,15H2,1-2H3,(H,27,28,31) BJIFHYQSYDRPLS-UHFFFAOYSA-N 183086 US9150546, I-164::US9688643, I-164::US9718790, I-0164 P2X purinoceptor 3 Homo sapiens 860 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183086 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183086&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821170 313634486 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330880 CC(C)n1c(=O)nc(Nc2cccc(OC(F)(F)F)c2)n(Cc2ccc(F)cc2)c1=O InChI=1S/C20H18F4N4O3/c1-12(2)28-18(29)26-17(25-15-4-3-5-16(10-15)31-20(22,23)24)27(19(28)30)11-13-6-8-14(21)9-7-13/h3-10,12H,11H2,1-2H3,(H,25,26,29) CFHUZVXARLKACN-UHFFFAOYSA-N 183087 US9150546, I-181::US9688643, I-181::US9718790, I-0181 P2X purinoceptor 3 Homo sapiens 985 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183087 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183087&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821033 313634487 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330881 CC(C)n1c(=O)nc(Nc2cccc(F)c2)n(Cc2ccc(F)cc2)c1=O InChI=1S/C19H18F2N4O2/c1-12(2)25-18(26)23-17(22-16-5-3-4-15(21)10-16)24(19(25)27)11-13-6-8-14(20)9-7-13/h3-10,12H,11H2,1-2H3,(H,22,23,26) PLOUZYMGEYTAOO-UHFFFAOYSA-N 183088 US9150546, I-182::US9688643, I-182::US9718790, I-0182 P2X purinoceptor 3 Homo sapiens 714 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183088 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183088&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821334 313634488 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330882 CC(C)Oc1ccc(Nc2nc(=O)n(C(C)C)c(=O)n2Cc2ccc(Cl)cc2)cc1 InChI=1S/C22H25ClN4O3/c1-14(2)27-21(28)25-20(24-18-9-11-19(12-10-18)30-15(3)4)26(22(27)29)13-16-5-7-17(23)8-6-16/h5-12,14-15H,13H2,1-4H3,(H,24,25,28) KRYNINNUFDZTED-UHFFFAOYSA-N 183089 US9150546, I-200::US9688643, I-200::US9718790, I-0200 P2X purinoceptor 3 Homo sapiens 128 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183089 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183089&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821207 313634489 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330883 CC(C)Oc1ccc(Nc2nc(=O)n(C(C)C)c(=O)n2Cc2ccc(F)cc2)cc1Cl InChI=1S/C22H24ClFN4O3/c1-13(2)28-21(29)26-20(25-17-9-10-19(18(23)11-17)31-14(3)4)27(22(28)30)12-15-5-7-16(24)8-6-15/h5-11,13-14H,12H2,1-4H3,(H,25,26,29) OWVXHUYXGFSYQY-UHFFFAOYSA-N 183090 US9150546, I-203::US9688643, I-203::US9718790, I-0203 P2X purinoceptor 3 Homo sapiens 110 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183090 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183090&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821264 313634490 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330884 CC(C)Oc1ccc(Nc2nc(=O)n(C(C)C)c(=O)n2Cc2ccc(F)cc2)cc1C(F)(F)F InChI=1S/C23H24F4N4O3/c1-13(2)31-21(32)29-20(30(22(31)33)12-15-5-7-16(24)8-6-15)28-17-9-10-19(34-14(3)4)18(11-17)23(25,26)27/h5-11,13-14H,12H2,1-4H3,(H,28,29,32) PTPBSADSFRUMGB-UHFFFAOYSA-N 183091 US9150546, I-204::US9688643, I-204::US9718790, I-0204 P2X purinoceptor 3 Homo sapiens 558 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183091 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183091&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821243 313634491 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330885 CC(C)Oc1ccc(Nc2nc(=O)n(C(C)C)c(=O)n2Cc2ccc(C)c(F)c2)cc1 InChI=1S/C23H27FN4O3/c1-14(2)28-22(29)26-21(25-18-8-10-19(11-9-18)31-15(3)4)27(23(28)30)13-17-7-6-16(5)20(24)12-17/h6-12,14-15H,13H2,1-5H3,(H,25,26,29) VXLKRVZZJMGIRW-UHFFFAOYSA-N 183092 US9150546, I-217::US9688643, I-217::US9718790, I-0217 P2X purinoceptor 3 Homo sapiens 268 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183092 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183092&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821277 313634492 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330886 CC(C)Oc1ccc(Nc2nc(=O)n(C(C)C)c(=O)n2Cc2ccc(C)c(c2)[N+]([O-])=O)cc1 InChI=1S/C23H27N5O5/c1-14(2)27-22(29)25-21(24-18-8-10-19(11-9-18)33-15(3)4)26(23(27)30)13-17-7-6-16(5)20(12-17)28(31)32/h6-12,14-15H,13H2,1-5H3,(H,24,25,29) DOEKZSQEACUAEJ-UHFFFAOYSA-N 183093 US9150546, I-218::US9688643, I-218::US9718790, I-0218 P2X purinoceptor 3 Homo sapiens 505 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183093 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183093&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 119099065 313634493 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330887 COC(=O)c1ccc(Nc2nc(=O)n(C(C)C)c(=O)n2Cc2ccc(F)cc2)cc1 InChI=1S/C21H21FN4O4/c1-13(2)26-20(28)24-19(23-17-10-6-15(7-11-17)18(27)30-3)25(21(26)29)12-14-4-8-16(22)9-5-14/h4-11,13H,12H2,1-3H3,(H,23,24,28) YCUSQGGRWIFGSQ-UHFFFAOYSA-N 183094 US9150546, I-221::US9688643, I-221::US9718790, I-0221 P2X purinoceptor 3 Homo sapiens 276 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183094 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183094&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821180 313634494 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330888 CC(C)n1c(=O)nc(NC(C)c2ccc(Cl)cc2)n(Cc2ccc(F)cc2)c1=O InChI=1S/C21H22ClFN4O2/c1-13(2)27-20(28)25-19(24-14(3)16-6-8-17(22)9-7-16)26(21(27)29)12-15-4-10-18(23)11-5-15/h4-11,13-14H,12H2,1-3H3,(H,24,25,28) AXDGKTCQGHHSCD-UHFFFAOYSA-N 183095 US9150546, I-223::US9688643, I-223::US9718790, I-0223 P2X purinoceptor 3 Homo sapiens 909 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183095 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183095&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821409 313634495 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330889 CC(C)Oc1ccc(Nc2nc(=O)n(C(C)C)c(=O)n2Cc2ccc(F)cc2)cc1C#N InChI=1S/C23H24FN5O3/c1-14(2)29-22(30)27-21(28(23(29)31)13-16-5-7-18(24)8-6-16)26-19-9-10-20(32-15(3)4)17(11-19)12-25/h5-11,14-15H,13H2,1-4H3,(H,26,27,30) RBEZCVPCKGYRNI-UHFFFAOYSA-N 183096 US9150546, I-227::US9688643, I-227::US9718790, I-0227 P2X purinoceptor 3 Homo sapiens 970 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183096 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183096&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821362 313634496 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330890 CC(C)Oc1ccc(Nc2nc(=O)n(C(C)C)c(=O)n2Cc2ccc(Cl)cc2)cc1Cl InChI=1S/C22H24Cl2N4O3/c1-13(2)28-21(29)26-20(25-17-9-10-19(18(24)11-17)31-14(3)4)27(22(28)30)12-15-5-7-16(23)8-6-15/h5-11,13-14H,12H2,1-4H3,(H,25,26,29) VRNDXKXJUGXSQA-UHFFFAOYSA-N 183097 US9150546, I-228::US9688643, I-228::US9718790, I-0228 P2X purinoceptor 3 Homo sapiens 31 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183097 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183097&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821066 313634497 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330891 CC(C)Oc1ccc(Nc2nc(=O)n(C(C)C)c(=O)n2Cc2ccc(Cl)cn2)cc1Cl InChI=1S/C21H23Cl2N5O3/c1-12(2)28-20(29)26-19(25-15-7-8-18(17(23)9-15)31-13(3)4)27(21(28)30)11-16-6-5-14(22)10-24-16/h5-10,12-13H,11H2,1-4H3,(H,25,26,29) AVXMYJGDEUEZIL-UHFFFAOYSA-N 183098 US9150546, I-234::US9688643, I-234::US9718790, I-0234 P2X purinoceptor 3 Homo sapiens 298 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183098 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183098&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821195 313634498 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330892 CC(C)Oc1ccc(Nc2nc(=O)n(C(C)C)c(=O)n2Cc2ccc(Cl)nc2)cc1Cl InChI=1S/C21H23Cl2N5O3/c1-12(2)28-20(29)26-19(25-15-6-7-17(16(22)9-15)31-13(3)4)27(21(28)30)11-14-5-8-18(23)24-10-14/h5-10,12-13H,11H2,1-4H3,(H,25,26,29) OKKVOHSWYVTAHO-UHFFFAOYSA-N 183099 US9150546, I-235::US9688643, I-235::US9718790, I-0235 P2X purinoceptor 3 Homo sapiens 985 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183099 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183099&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821064 313634499 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330893 COCCOc1ccc(Nc2nc(=O)n(C(C)C)c(=O)n2Cc2ccc(Cl)cc2)cc1Cl InChI=1S/C22H24Cl2N4O4/c1-14(2)28-21(29)26-20(27(22(28)30)13-15-4-6-16(23)7-5-15)25-17-8-9-19(18(24)12-17)32-11-10-31-3/h4-9,12,14H,10-11,13H2,1-3H3,(H,25,26,29) IAQHVVYKMDVUFT-UHFFFAOYSA-N 183100 US9150546, I-237::US9688643, I-237::US9718790, I-0237 P2X purinoceptor 3 Homo sapiens 230 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183100 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183100&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821247 313634500 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330894 COC(=O)c1ccc(Nc2nc(=O)n(C(C)C)c(=O)n2Cc2ccc(F)cc2)cc1Cl InChI=1S/C21H20ClFN4O4/c1-12(2)27-20(29)25-19(24-15-8-9-16(17(22)10-15)18(28)31-3)26(21(27)30)11-13-4-6-14(23)7-5-13/h4-10,12H,11H2,1-3H3,(H,24,25,29) UPIQRRIDCVZSEU-UHFFFAOYSA-N 183101 US9150546, I-238::US9688643, I-238::US9718790, I-0238 P2X purinoceptor 3 Homo sapiens 658 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183101 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183101&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76820978 313634501 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330895 CC(C)n1c(=O)nc(Nc2ccc(OC3CCOCC3)c(Cl)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H26Cl2N4O4/c1-15(2)30-23(31)28-22(29(24(30)32)14-16-3-5-17(25)6-4-16)27-18-7-8-21(20(26)13-18)34-19-9-11-33-12-10-19/h3-8,13,15,19H,9-12,14H2,1-2H3,(H,27,28,31) DDNUNYHYRGZFMC-UHFFFAOYSA-N 183102 US9150546, I-239::US9688643, I-239::US9718790, I-0239 P2X purinoceptor 3 Homo sapiens 116 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183102 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183102&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821040 313634502 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330896 CC(C)n1c(=O)nc(Nc2ccc(Oc3ccccc3)c(Cl)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H22Cl2N4O3/c1-16(2)31-24(32)29-23(30(25(31)33)15-17-8-10-18(26)11-9-17)28-19-12-13-22(21(27)14-19)34-20-6-4-3-5-7-20/h3-14,16H,15H2,1-2H3,(H,28,29,32) NFSZOFAKVQXYIY-UHFFFAOYSA-N 183103 US9150546, I-240::US9688643, I-240 P2X purinoceptor 3 Homo sapiens 953 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183103 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183103&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821125 313634503 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330897 CCOC(=O)COc1ccc(Nc2nc(=O)n(C(C)C)c(=O)n2Cc2ccc(Cl)cc2)cc1Cl InChI=1S/C23H24Cl2N4O5/c1-4-33-20(30)13-34-19-10-9-17(11-18(19)25)26-21-27-22(31)29(14(2)3)23(32)28(21)12-15-5-7-16(24)8-6-15/h5-11,14H,4,12-13H2,1-3H3,(H,26,27,31) YECJAZONJNUKOF-UHFFFAOYSA-N 183104 US9150546, I-241::US9688643, I-241::US9718790, I-0241 P2X purinoceptor 3 Homo sapiens 447 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183104 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183104&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821187 313634504 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330898 CC(C)n1c(=O)nc(Nc2ccc(OC3CCNCC3)c(Cl)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H27Cl2N5O3/c1-15(2)31-23(32)29-22(30(24(31)33)14-16-3-5-17(25)6-4-16)28-18-7-8-21(20(26)13-18)34-19-9-11-27-12-10-19/h3-8,13,15,19,27H,9-12,14H2,1-2H3,(H,28,29,32) LBCWOSHEBIVJGF-UHFFFAOYSA-N 183105 US9150546, I-242::US9688643, I-242::US9718790, I-0242 P2X purinoceptor 3 Homo sapiens 787 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183105 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183105&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76820942 313634505 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330899 COc1ccc(Nc2nc(=O)n(C(C)C)c(=O)n2Cc2ccc(Cl)cc2)cc1Cl InChI=1S/C20H20Cl2N4O3/c1-12(2)26-19(27)24-18(23-15-8-9-17(29-3)16(22)10-15)25(20(26)28)11-13-4-6-14(21)7-5-13/h4-10,12H,11H2,1-3H3,(H,23,24,27) MOCLUEIBJVFEID-UHFFFAOYSA-N 183106 US9150546, I-243::US9688643, I-243::US9718790, I-0243 P2X purinoceptor 3 Homo sapiens 450 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183106 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183106&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821167 313634506 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330900 CC(C)Oc1ccc(Nc2nc(=O)n(C(C)C)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C22H24ClFN4O3/c1-13(2)28-21(29)26-20(25-17-9-10-19(18(24)11-17)31-14(3)4)27(22(28)30)12-15-5-7-16(23)8-6-15/h5-11,13-14H,12H2,1-4H3,(H,25,26,29) NEEKIVKPSARQCC-UHFFFAOYSA-N 183107 US9150546, I-244::US9688643, I-244::US9718790, I-0244 P2X purinoceptor 3 Homo sapiens 45 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183107 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183107&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821359 313634507 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330901 CC(C)Oc1ccc(Nc2nc(=O)n(C(C)C)c(=O)n2Cc2ccc(Cl)cc2)cc1C#N InChI=1S/C23H24ClN5O3/c1-14(2)29-22(30)27-21(28(23(29)31)13-16-5-7-18(24)8-6-16)26-19-9-10-20(32-15(3)4)17(11-19)12-25/h5-11,14-15H,13H2,1-4H3,(H,26,27,30) XNSXTWGZTGQSMH-UHFFFAOYSA-N 183108 US9150546, I-245::US9688643, I-245::US9718790, I-0245 P2X purinoceptor 3 Homo sapiens 168 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183108 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183108&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76820964 313634508 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330902 CC(C)n1c(=O)nc(Nc2ccc3[nH]c(=O)oc3c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C20H18ClN5O4/c1-11(2)26-18(27)24-17(22-14-7-8-15-16(9-14)30-19(28)23-15)25(20(26)29)10-12-3-5-13(21)6-4-12/h3-9,11H,10H2,1-2H3,(H,23,28)(H,22,24,27) BRLFUVYLTKDYOS-UHFFFAOYSA-N 183109 US9150546, I-246::US9688643, I-246::US9718790, I-0246 P2X purinoceptor 3 Homo sapiens 996 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183109 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183109&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 77888198 313634509 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330903 COC(=O)c1ccc(Nc2nc(=O)n(C(C)C)c(=O)n2Cc2ccc(Cl)cc2)cc1 InChI=1S/C21H21ClN4O4/c1-13(2)26-20(28)24-19(23-17-10-6-15(7-11-17)18(27)30-3)25(21(26)29)12-14-4-8-16(22)9-5-14/h4-11,13H,12H2,1-3H3,(H,23,24,28) UDKRZHKBWBJIRH-UHFFFAOYSA-N 183110 US9150546, I-248::US9688643, I-248::US9718790, I-0248 P2X purinoceptor 3 Homo sapiens 420 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183110 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183110&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821342 313634510 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330904 CC(C)Oc1ccc(Nc2nc(=O)n(C(C)C)c(=O)n2Cc2ccc(Cl)s2)cc1F InChI=1S/C20H22ClFN4O3S/c1-11(2)26-19(27)24-18(25(20(26)28)10-14-6-8-17(21)30-14)23-13-5-7-16(15(22)9-13)29-12(3)4/h5-9,11-12H,10H2,1-4H3,(H,23,24,27) VRGLWZSDHZCAOI-UHFFFAOYSA-N 183111 US9150546, I-254::US9688643, I-254::US9718790, I-0254 P2X purinoceptor 3 Homo sapiens 144 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183111 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183111&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821021 313634511 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330905 CC(C)NC(=O)c1ccc(Nc2nc(=O)n(C(C)C)c(=O)n2Cc2ccc(Cl)cc2)cc1 InChI=1S/C23H26ClN5O3/c1-14(2)25-20(30)17-7-11-19(12-8-17)26-21-27-22(31)29(15(3)4)23(32)28(21)13-16-5-9-18(24)10-6-16/h5-12,14-15H,13H2,1-4H3,(H,25,30)(H,26,27,31) SIGZERSAIQXHMB-UHFFFAOYSA-N 183112 US9150546, I-255::US9688643, I-255::US9718790, I-0255 P2X purinoceptor 3 Homo sapiens 520 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183112 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183112&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821432 313634512 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330906 CC(C)CNC(=O)c1ccc(Nc2nc(=O)n(C(C)C)c(=O)n2Cc2ccc(Cl)cc2)cc1 InChI=1S/C24H28ClN5O3/c1-15(2)13-26-21(31)18-7-11-20(12-8-18)27-22-28-23(32)30(16(3)4)24(33)29(22)14-17-5-9-19(25)10-6-17/h5-12,15-16H,13-14H2,1-4H3,(H,26,31)(H,27,28,32) HXHVMCCJJHMFTF-UHFFFAOYSA-N 183113 US9150546, I-256::US9688643, I-256::US9718790, I-0256 P2X purinoceptor 3 Homo sapiens 867 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183113 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183113&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821253 313634513 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330907 CC(C)n1c(=O)nc(Nc2ccc(cc2)C(=O)NC2CC2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H24ClN5O3/c1-14(2)29-22(31)27-21(28(23(29)32)13-15-3-7-17(24)8-4-15)26-19-9-5-16(6-10-19)20(30)25-18-11-12-18/h3-10,14,18H,11-13H2,1-2H3,(H,25,30)(H,26,27,31) KLIMXRDHTVGIJE-UHFFFAOYSA-N 183114 US9150546, I-257::US9688643, I-257::US9718790, I-0257 P2X purinoceptor 3 Homo sapiens 682 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183114 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183114&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821283 313634514 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330908 CC(C)n1c(=O)nc(Nc2ccc(cc2)C(=O)NCC2CC2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H26ClN5O3/c1-15(2)30-23(32)28-22(29(24(30)33)14-17-5-9-19(25)10-6-17)27-20-11-7-18(8-12-20)21(31)26-13-16-3-4-16/h5-12,15-16H,3-4,13-14H2,1-2H3,(H,26,31)(H,27,28,32) WGVHUASKTDZQAF-UHFFFAOYSA-N 183115 US9150546, I-258::US9688643, I-258::US9718790, I-0258 P2X purinoceptor 3 Homo sapiens 683 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183115 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183115&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821435 313634515 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330909 CC(C)n1c(=O)nc(Nc2ccc(cc2)C(=O)Nc2ccccc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H24ClN5O3/c1-17(2)32-25(34)30-24(31(26(32)35)16-18-8-12-20(27)13-9-18)29-22-14-10-19(11-15-22)23(33)28-21-6-4-3-5-7-21/h3-15,17H,16H2,1-2H3,(H,28,33)(H,29,30,34) SOXGLRSLVYLHIY-UHFFFAOYSA-N 183116 US9150546, I-266::US9688643, I-266 P2X purinoceptor 3 Homo sapiens 861 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183116 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183116&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821321 313634516 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330910 CC(C)Oc1ccc(Nc2nc(=O)[nH]c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C19H18ClFN4O3/c1-11(2)28-16-8-7-14(9-15(16)21)22-17-23-18(26)24-19(27)25(17)10-12-3-5-13(20)6-4-12/h3-9,11H,10H2,1-2H3,(H2,22,23,24,26,27) AJVAAPSNYAVHDF-UHFFFAOYSA-N 183117 US9150546, I-269::US9688643, I-269::US9718790, I-0269 P2X purinoceptor 3 Homo sapiens 415 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183117 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183117&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76820948 313634517 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330911 COc1cc(Cl)ccc1Cn1c(Nc2ccc(OC(C)C)c(F)c2)nc(=O)n(C(C)C)c1=O InChI=1S/C23H26ClFN4O4/c1-13(2)29-22(30)27-21(26-17-8-9-19(18(25)11-17)33-14(3)4)28(23(29)31)12-15-6-7-16(24)10-20(15)32-5/h6-11,13-14H,12H2,1-5H3,(H,26,27,30) GTFVMMIIRJHQNA-UHFFFAOYSA-N 183118 US9150546, I-270::US9688643, I-270::US9718790, I-0270 P2X purinoceptor 3 Homo sapiens 271 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183118 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183118&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821318 313634518 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330912 CC(C)Oc1ccc(Nc2nc(=O)n(CC3CC3)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C23H24ClFN4O3/c1-14(2)32-20-10-9-18(11-19(20)25)26-21-27-22(30)29(13-15-3-4-15)23(31)28(21)12-16-5-7-17(24)8-6-16/h5-11,14-15H,3-4,12-13H2,1-2H3,(H,26,27,30) KWLZBQHILCASGJ-UHFFFAOYSA-N 183119 US9150546, I-271::US9688643, I-271::US9718790, I-0271 P2X purinoceptor 3 Homo sapiens 32 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183119 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183119&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821043 313634519 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330913 CC(C)Oc1ccc(Nc2nc(=O)n(CCN(C)C)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C23H27ClFN5O3/c1-15(2)33-20-10-9-18(13-19(20)25)26-21-27-22(31)29(12-11-28(3)4)23(32)30(21)14-16-5-7-17(24)8-6-16/h5-10,13,15H,11-12,14H2,1-4H3,(H,26,27,31) UCAYJQSCZMASBW-UHFFFAOYSA-N 183120 US9150546, I-272::US9688643, I-272::US9718790, I-0272 P2X purinoceptor 3 Homo sapiens 180 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183120 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183120&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821009 313634520 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330914 CC(C)Oc1ccc(Nc2nc(=O)n(CCO)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C21H22ClFN4O4/c1-13(2)31-18-8-7-16(11-17(18)23)24-19-25-20(29)26(9-10-28)21(30)27(19)12-14-3-5-15(22)6-4-14/h3-8,11,13,28H,9-10,12H2,1-2H3,(H,24,25,29) XKUBPFCGXISTNR-UHFFFAOYSA-N 183121 US9150546, I-273::US9688643, I-273::US9718790, I-0273 P2X purinoceptor 3 Homo sapiens 38 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183121 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183121&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821279 313634521 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330915 CC(C)Oc1ccc(Nc2nc(=O)n(CC(C)(CO)CO)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C24H28ClFN4O5/c1-15(2)35-20-9-8-18(10-19(20)26)27-21-28-22(33)30(12-24(3,13-31)14-32)23(34)29(21)11-16-4-6-17(25)7-5-16/h4-10,15,31-32H,11-14H2,1-3H3,(H,27,28,33) UTJLWFYQRDUGFC-UHFFFAOYSA-N 183122 US9150546, I-274::US9688643, I-274::US9718790, I-0274 P2X purinoceptor 3 Homo sapiens 9 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183122 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183122&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76388509 313634522 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330916 CC(C)Oc1ccc(Nc2nc(=O)n(CC3CCOCC3)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C25H28ClFN4O4/c1-16(2)35-22-8-7-20(13-21(22)27)28-23-29-24(32)31(15-18-9-11-34-12-10-18)25(33)30(23)14-17-3-5-19(26)6-4-17/h3-8,13,16,18H,9-12,14-15H2,1-2H3,(H,28,29,32) KMGNDJHSKCRYEF-UHFFFAOYSA-N 183123 US9150546, I-275::US9688643, I-275::US9718790, I-0275 P2X purinoceptor 3 Homo sapiens 21 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183123 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183123&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821452 313634523 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330917 CC(C)Oc1ccc(Nc2nc(=O)n(CC(CO)CO)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C23H26ClFN4O5/c1-14(2)34-20-8-7-18(9-19(20)25)26-21-27-22(32)29(11-16(12-30)13-31)23(33)28(21)10-15-3-5-17(24)6-4-15/h3-9,14,16,30-31H,10-13H2,1-2H3,(H,26,27,32) RUZOIAXGYPSNOT-UHFFFAOYSA-N 183124 US9150546, I-276::US9688643, I-276::US9718790, I-0276 P2X purinoceptor 3 Homo sapiens 12 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183124 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183124&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821269 313634524 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330918 CCn1c(=O)nc(Nc2ccc(OC(C)C)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C21H22ClFN4O3/c1-4-26-20(28)25-19(24-16-9-10-18(17(23)11-16)30-13(2)3)27(21(26)29)12-14-5-7-15(22)8-6-14/h5-11,13H,4,12H2,1-3H3,(H,24,25,28) ZFOLLFDANAKBTB-UHFFFAOYSA-N 183125 US9150546, I-277::US9688643, I-277::US9718790, I-0277 P2X purinoceptor 3 Homo sapiens 38 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183125 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183125&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821275 313634525 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330919 OCCn1c(=O)nc(Nc2ccc(cc2)-c2ccon2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C21H18ClN5O4/c22-16-5-1-14(2-6-16)13-27-19(24-20(29)26(10-11-28)21(27)30)23-17-7-3-15(4-8-17)18-9-12-31-25-18/h1-9,12,28H,10-11,13H2,(H,23,24,29) IBYTZLXTXPKYSB-UHFFFAOYSA-N 183126 US9150546, I-278::US9688643, I-278::US9718790, I-0278 P2X purinoceptor 3 Homo sapiens 931 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183126 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183126&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821140 313634526 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330920 COCCn1c(=O)nc(Nc2ccc(OC(C)C)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C22H24ClFN4O4/c1-14(2)32-19-9-8-17(12-18(19)24)25-20-26-21(29)27(10-11-31-3)22(30)28(20)13-15-4-6-16(23)7-5-15/h4-9,12,14H,10-11,13H2,1-3H3,(H,25,26,29) LFPJLMIAJIYGIU-UHFFFAOYSA-N 183127 US9150546, I-280::US9688643, I-280::US9718790, I-0280 P2X purinoceptor 3 Homo sapiens 30 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183127 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183127&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821447 313634527 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330921 CC(C)Oc1ccc(Nc2nc(=O)n(CCN3CCOCC3)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C25H29ClFN5O4/c1-17(2)36-22-8-7-20(15-21(22)27)28-23-29-24(33)31(10-9-30-11-13-35-14-12-30)25(34)32(23)16-18-3-5-19(26)6-4-18/h3-8,15,17H,9-14,16H2,1-2H3,(H,28,29,33) TVASFVKDNGFONS-UHFFFAOYSA-N 183128 US9150546, I-281::US9688643, I-281::US9718790, I-0281 P2X purinoceptor 3 Homo sapiens 12 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183128 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183128&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821220 313634528 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330922 CC(C)Oc1ccc(Nc2nc(=O)n(CCN3CCCCC3)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C26H31ClFN5O3/c1-18(2)36-23-11-10-21(16-22(23)28)29-24-30-25(34)32(15-14-31-12-4-3-5-13-31)26(35)33(24)17-19-6-8-20(27)9-7-19/h6-11,16,18H,3-5,12-15,17H2,1-2H3,(H,29,30,34) AQIFGVPXDZVNGA-UHFFFAOYSA-N 183129 US9150546, I-282::US9688643, I-282::US9718790, I-0282 P2X purinoceptor 3 Homo sapiens 27 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183129 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183129&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821381 313634529 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330923 CC(C)Oc1ccc(Nc2nc(=O)n(CC(F)(F)C(O)=O)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C22H20ClF3N4O5/c1-12(2)35-17-8-7-15(9-16(17)24)27-19-28-20(33)30(11-22(25,26)18(31)32)21(34)29(19)10-13-3-5-14(23)6-4-13/h3-9,12H,10-11H2,1-2H3,(H,31,32)(H,27,28,33) IXCROGNFOOAIDL-UHFFFAOYSA-N 183130 US9150546, I-283::US9688643, I-283::US9718790, I-0283 P2X purinoceptor 3 Homo sapiens 19 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183130 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183130&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821358 313634530 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330924 CC(C)Oc1ccc(Nc2nc(=O)n(CC(O)=O)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C21H20ClFN4O5/c1-12(2)32-17-8-7-15(9-16(17)23)24-19-25-20(30)27(11-18(28)29)21(31)26(19)10-13-3-5-14(22)6-4-13/h3-9,12H,10-11H2,1-2H3,(H,28,29)(H,24,25,30) PLIWLWCQSVFBEL-UHFFFAOYSA-N 183131 US9150546, I-284::US9688643, I-284::US9718790, I-0284 P2X purinoceptor 3 Homo sapiens 629 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183131 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183131&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76820980 313634531 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330925 CC(C)Oc1ccc(Nc2nc(=O)n(CCCO)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C22H24ClFN4O4/c1-14(2)32-19-9-8-17(12-18(19)24)25-20-26-21(30)27(10-3-11-29)22(31)28(20)13-15-4-6-16(23)7-5-15/h4-9,12,14,29H,3,10-11,13H2,1-2H3,(H,25,26,30) NOTRDLDWXSPKCF-UHFFFAOYSA-N 183132 US9150546, I-285::US9688643, I-285::US9718790, I-0285 P2X purinoceptor 3 Homo sapiens 14 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183132 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183132&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821080 313634532 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330926 CC(C)Oc1ccc(Nc2nc(=O)n(C(CO)CO)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C22H24ClFN4O5/c1-13(2)33-19-8-7-16(9-18(19)24)25-20-26-21(31)28(17(11-29)12-30)22(32)27(20)10-14-3-5-15(23)6-4-14/h3-9,13,17,29-30H,10-12H2,1-2H3,(H,25,26,31) MSADNIYDADHRDA-UHFFFAOYSA-N 183133 US9150546, I-286::US9688643, I-286::US9718790, I-0286 P2X purinoceptor 3 Homo sapiens 277 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183133 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183133&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821257 313634533 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330927 Clc1ccc(Cn2c(Nc3ccc(cc3)-c3ccon3)nc(=O)n(CCN3CCOCC3)c2=O)cc1 InChI=1S/C25H25ClN6O4/c26-20-5-1-18(2-6-20)17-32-23(27-21-7-3-19(4-8-21)22-9-14-36-29-22)28-24(33)31(25(32)34)11-10-30-12-15-35-16-13-30/h1-9,14H,10-13,15-17H2,(H,27,28,33) HZBDYVIANCHSDU-UHFFFAOYSA-N 183134 US9150546, I-287::US9688643, I-287::US9718790, I-0287 P2X purinoceptor 3 Homo sapiens 222 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183134 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183134&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821177 313634534 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330928 CC(C)Oc1ccc(Nc2nc(=O)n(CC#N)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C21H19ClFN5O3/c1-13(2)31-18-8-7-16(11-17(18)23)25-19-26-20(29)27(10-9-24)21(30)28(19)12-14-3-5-15(22)6-4-14/h3-8,11,13H,10,12H2,1-2H3,(H,25,26,29) SHZBDZQJVOICIK-UHFFFAOYSA-N 183135 US9150546, I-288::US9688643, I-288::US9718790, I-0288 P2X purinoceptor 3 Homo sapiens 93 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183135 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183135&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821284 313634535 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330929 CC(C)Oc1ccc(Nc2nc(=O)n(CCC(O)=O)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C22H22ClFN4O5/c1-13(2)33-18-8-7-16(11-17(18)24)25-20-26-21(31)27(10-9-19(29)30)22(32)28(20)12-14-3-5-15(23)6-4-14/h3-8,11,13H,9-10,12H2,1-2H3,(H,29,30)(H,25,26,31) MCTZNTUJEJXMFG-UHFFFAOYSA-N 183136 US9150546, I-289::US9688643, I-289::US9718790, I-0289 P2X purinoceptor 3 Homo sapiens 66 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183136 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183136&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821389 313634536 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330930 CC(C)Oc1ccc(Nc2nc(=O)n(CCN)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C21H23ClFN5O3/c1-13(2)31-18-8-7-16(11-17(18)23)25-19-26-20(29)27(10-9-24)21(30)28(19)12-14-3-5-15(22)6-4-14/h3-8,11,13H,9-10,12,24H2,1-2H3,(H,25,26,29) SAZRRLWYPWSLHE-UHFFFAOYSA-N 183137 US9150546, I-290::US9688643, I-290::US9718790, I-0290 P2X purinoceptor 3 Homo sapiens 266 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183137 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183137&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821151 313634537 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330931 CC(C)Oc1ccc(Nc2nc(=O)n(CCC#N)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C22H21ClFN5O3/c1-14(2)32-19-9-8-17(12-18(19)24)26-20-27-21(30)28(11-3-10-25)22(31)29(20)13-15-4-6-16(23)7-5-15/h4-9,12,14H,3,11,13H2,1-2H3,(H,26,27,30) MUAVUCGFIWKKLX-UHFFFAOYSA-N 183138 US9150546, I-291::US9688643, I-291::US9718790, I-0291 P2X purinoceptor 3 Homo sapiens 9 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183138 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183138&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821316 313634538 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330932 CC(C)Oc1ccc(Nc2nc(=O)n(CCNC(C)=O)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C23H25ClFN5O4/c1-14(2)34-20-9-8-18(12-19(20)25)27-21-28-22(32)29(11-10-26-15(3)31)23(33)30(21)13-16-4-6-17(24)7-5-16/h4-9,12,14H,10-11,13H2,1-3H3,(H,26,31)(H,27,28,32) VLKNEIAWFTVSEB-UHFFFAOYSA-N 183139 US9150546, I-292::US9688643, I-292::US9718790, I-0292 P2X purinoceptor 3 Homo sapiens 34 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183139 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183139&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 77393823 313634539 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330933 CC(C)Oc1ccc(Nc2nc(=O)n(CC(=O)N(C)C)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C23H25ClFN5O4/c1-14(2)34-19-10-9-17(11-18(19)25)26-21-27-22(32)30(13-20(31)28(3)4)23(33)29(21)12-15-5-7-16(24)8-6-15/h5-11,14H,12-13H2,1-4H3,(H,26,27,32) RCVSMVSKFKNQJB-UHFFFAOYSA-N 183140 US9150546, I-293::US9688643, I-293::US9718790, I-0293 P2X purinoceptor 3 Homo sapiens 351 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183140 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183140&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821093 313634540 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330934 CNC(=O)Cn1c(=O)nc(Nc2ccc(OC(C)C)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C22H23ClFN5O4/c1-13(2)33-18-9-8-16(10-17(18)24)26-20-27-21(31)29(12-19(30)25-3)22(32)28(20)11-14-4-6-15(23)7-5-14/h4-10,13H,11-12H2,1-3H3,(H,25,30)(H,26,27,31) PCFINRYADQXVKE-UHFFFAOYSA-N 183141 US9150546, I-294::US9688643, I-294::US9718790, I-0294 P2X purinoceptor 3 Homo sapiens 40 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183141 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183141&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76820949 313634541 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330935 CC(C)Oc1ccc(Nc2nc(=O)n(CC(N)=O)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C21H21ClFN5O4/c1-12(2)32-17-8-7-15(9-16(17)23)25-19-26-20(30)28(11-18(24)29)21(31)27(19)10-13-3-5-14(22)6-4-13/h3-9,12H,10-11H2,1-2H3,(H2,24,29)(H,25,26,30) XUQJWMNWTZFCLU-UHFFFAOYSA-N 183142 US9150546, I-295::US9688643, I-295::US9718790, I-0295 P2X purinoceptor 3 Homo sapiens 46 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183142 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183142&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821065 313634542 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330936 CC(C)Oc1ccc(Nc2nc(=O)n(C(C)=O)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C21H20ClFN4O4/c1-12(2)31-18-9-8-16(10-17(18)23)24-19-25-20(29)27(13(3)28)21(30)26(19)11-14-4-6-15(22)7-5-14/h4-10,12H,11H2,1-3H3,(H,24,25,29) TZVHQOORWPGESA-UHFFFAOYSA-N 183143 US9150546, I-296::US9688643, I-296::US9718790, I-0296 P2X purinoceptor 3 Homo sapiens 176 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183143 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183143&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821385 313634543 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330937 CC(C)Oc1ccc(Nc2nc(=O)n(CCC(=O)N(C)C)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C24H27ClFN5O4/c1-15(2)35-20-10-9-18(13-19(20)26)27-22-28-23(33)30(12-11-21(32)29(3)4)24(34)31(22)14-16-5-7-17(25)8-6-16/h5-10,13,15H,11-12,14H2,1-4H3,(H,27,28,33) SNURGCWNVNKCDB-UHFFFAOYSA-N 183144 US9150546, I-297::US9688643, I-297::US9718790, I-0297 P2X purinoceptor 3 Homo sapiens 45 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183144 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183144&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821416 313634544 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330938 CNC(=O)CCn1c(=O)nc(Nc2ccc(OC(C)C)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H25ClFN5O4/c1-14(2)34-19-9-8-17(12-18(19)25)27-21-28-22(32)29(11-10-20(31)26-3)23(33)30(21)13-15-4-6-16(24)7-5-15/h4-9,12,14H,10-11,13H2,1-3H3,(H,26,31)(H,27,28,32) XGSOCLWAPUYZQU-UHFFFAOYSA-N 183145 US9150546, I-298::US9688643, I-298::US9718790, I-0298 P2X purinoceptor 3 Homo sapiens 27 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183145 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183145&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821333 313634545 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330939 CC(C)Oc1ccc(Nc2nc(=O)n(CCC(N)=O)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C22H23ClFN5O4/c1-13(2)33-18-8-7-16(11-17(18)24)26-20-27-21(31)28(10-9-19(25)30)22(32)29(20)12-14-3-5-15(23)6-4-14/h3-8,11,13H,9-10,12H2,1-2H3,(H2,25,30)(H,26,27,31) UFFMZHJMYPBKRN-UHFFFAOYSA-N 183146 US9150546, I-299::US9688643, I-299::US9718790, I-0299 P2X purinoceptor 3 Homo sapiens 46 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183146 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183146&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821155 313634546 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330940 CC(C)Oc1ccc(Nc2nc(=O)n(Cc3ccccn3)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C25H23ClFN5O3/c1-16(2)35-22-11-10-19(13-21(22)27)29-23-30-24(33)32(15-20-5-3-4-12-28-20)25(34)31(23)14-17-6-8-18(26)9-7-17/h3-13,16H,14-15H2,1-2H3,(H,29,30,33) XXENJCJYUMNOPR-UHFFFAOYSA-N 183147 US9150546, I-300::US9688643, I-300::US9718790, I-0300 P2X purinoceptor 3 Homo sapiens 25 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183147 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183147&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821289 313634547 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330941 CC(C)Oc1ccc(Nc2nc(=O)n(Cc3ccccc3)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C26H24ClFN4O3/c1-17(2)35-23-13-12-21(14-22(23)28)29-24-30-25(33)32(16-18-6-4-3-5-7-18)26(34)31(24)15-19-8-10-20(27)11-9-19/h3-14,17H,15-16H2,1-2H3,(H,29,30,33) CRXFJQFRHPYGEW-UHFFFAOYSA-N 183148 US9150546, I-301::US9688643, I-301::US9718790, I-0301 P2X purinoceptor 3 Homo sapiens 48 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183148 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183148&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821148 313634548 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330942 COc1ccc(Nc2nc(=O)n(CCO)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C19H18ClFN4O4/c1-29-16-7-6-14(10-15(16)21)22-17-23-18(27)24(8-9-26)19(28)25(17)11-12-2-4-13(20)5-3-12/h2-7,10,26H,8-9,11H2,1H3,(H,22,23,27) VQLURVNMKVRPBI-UHFFFAOYSA-N 183149 US9150546, I-305::US9688643, I-305::US9718790, I-0305 P2X purinoceptor 3 Homo sapiens 946 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183149 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183149&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821291 313634549 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330943 CCOc1ccc(Nc2nc(=O)n(CCO)c(=O)n2Cc2ccc(Cl)cc2)cc1 InChI=1S/C20H21ClN4O4/c1-2-29-17-9-7-16(8-10-17)22-18-23-19(27)24(11-12-26)20(28)25(18)13-14-3-5-15(21)6-4-14/h3-10,26H,2,11-13H2,1H3,(H,22,23,27) PCNUGCNYROAAGW-UHFFFAOYSA-N 183150 US9150546, I-307::US9688643, I-307::US9718790, I-0307 P2X purinoceptor 3 Homo sapiens 250 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183150 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183150&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821438 313634550 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330944 OCCn1c(=O)nc(Nc2cccc(OC(F)(F)F)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C19H16ClF3N4O4/c20-13-6-4-12(5-7-13)11-27-16(25-17(29)26(8-9-28)18(27)30)24-14-2-1-3-15(10-14)31-19(21,22)23/h1-7,10,28H,8-9,11H2,(H,24,25,29) SZPOVAGBNOSRKL-UHFFFAOYSA-N 183151 US9150546, I-309::US9688643, I-309::US9718790, I-0309 P2X purinoceptor 3 Homo sapiens 357 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183151 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183151&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821085 313634551 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330945 CC(C)Oc1ccc(Nc2nc(=O)n(C(F)F)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C20H18ClF3N4O3/c1-11(2)31-16-8-7-14(9-15(16)22)25-18-26-19(29)28(17(23)24)20(30)27(18)10-12-3-5-13(21)6-4-12/h3-9,11,17H,10H2,1-2H3,(H,25,26,29) UKOOLOVTENGDOT-UHFFFAOYSA-N 183152 US9150546, I-310::US9688643, I-310::US9718790, I-0310 P2X purinoceptor 3 Homo sapiens 389 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183152 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183152&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821325 313634552 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330946 OCCn1c(=O)nc(Nc2ccc(cc2)N2CCCCC2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H26ClN5O3/c24-18-6-4-17(5-7-18)16-29-21(26-22(31)28(14-15-30)23(29)32)25-19-8-10-20(11-9-19)27-12-2-1-3-13-27/h4-11,30H,1-3,12-16H2,(H,25,26,31) OJQRPQPOPGAGNZ-UHFFFAOYSA-N 183153 US9150546, I-311::US9688643, I-311::US9718790, I-0311 P2X purinoceptor 3 Homo sapiens 142 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183153 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183153&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821457 313634553 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330947 CCOc1ccc(Nc2nc(=O)n(CCO)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C20H20ClFN4O4/c1-2-30-17-8-7-15(11-16(17)22)23-18-24-19(28)25(9-10-27)20(29)26(18)12-13-3-5-14(21)6-4-13/h3-8,11,27H,2,9-10,12H2,1H3,(H,23,24,28) UVRGSNWJIMHPJR-UHFFFAOYSA-N 183154 US9150546, I-312::US9688643, I-312::US9718790, I-0312 P2X purinoceptor 3 Homo sapiens 104 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183154 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183154&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76820982 313634554 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330948 OCCn1c(=O)nc(Nc2cccc(c2)C(F)(F)F)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C19H16ClF3N4O3/c20-14-6-4-12(5-7-14)11-27-16(25-17(29)26(8-9-28)18(27)30)24-15-3-1-2-13(10-15)19(21,22)23/h1-7,10,28H,8-9,11H2,(H,24,25,29) GNJMVKXDASLTBV-UHFFFAOYSA-N 183155 US9150546, I-313::US9688643, I-313::US9718790, I-0313 P2X purinoceptor 3 Homo sapiens 178 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183155 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183155&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821293 313634555 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330949 OCCn1c(=O)nc(Nc2cccc(c2)-c2ccon2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C21H18ClN5O4/c22-16-6-4-14(5-7-16)13-27-19(24-20(29)26(9-10-28)21(27)30)23-17-3-1-2-15(12-17)18-8-11-31-25-18/h1-8,11-12,28H,9-10,13H2,(H,23,24,29) DDPKJFUGSSHNQH-UHFFFAOYSA-N 183156 US9150546, I-314::US9688643, I-314::US9718790, I-0314 P2X purinoceptor 3 Homo sapiens 555 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183156 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183156&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821005 313634556 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330950 OCCn1c(=O)nc(Nc2ccc(c(F)c2)C(F)(F)F)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C19H15ClF4N4O3/c20-12-3-1-11(2-4-12)10-28-16(26-17(30)27(7-8-29)18(28)31)25-13-5-6-14(15(21)9-13)19(22,23)24/h1-6,9,29H,7-8,10H2,(H,25,26,30) DGUIURWTUWHUDG-UHFFFAOYSA-N 183157 US9150546, I-315::US9688643, I-315::US9718790, I-0315 P2X purinoceptor 3 Homo sapiens 183 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183157 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183157&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821237 313634557 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330951 OCCn1c(=O)nc(Nc2ccc(F)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C18H15ClF2N4O3/c19-12-3-1-11(2-4-12)10-25-16(22-13-5-6-14(20)15(21)9-13)23-17(27)24(7-8-26)18(25)28/h1-6,9,26H,7-8,10H2,(H,22,23,27) SPLPIBKXRGJGLE-UHFFFAOYSA-N 183158 US9150546, I-316::US9688643, I-316::US9718790, I-0316 P2X purinoceptor 3 Homo sapiens 712 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183158 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183158&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821214 313634558 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330952 CC(C)Oc1ccc(Nc2nc(=O)n(CCCN)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C22H25ClFN5O3/c1-14(2)32-19-9-8-17(12-18(19)24)26-20-27-21(30)28(11-3-10-25)22(31)29(20)13-15-4-6-16(23)7-5-15/h4-9,12,14H,3,10-11,13,25H2,1-2H3,(H,26,27,30) OIMNDBFRVLTWKG-UHFFFAOYSA-N 183159 US9150546, I-317::US9688643, I-317::US9718790, I-0317 P2X purinoceptor 3 Homo sapiens 137 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183159 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183159&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821352 313634559 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330953 CC(C)Oc1ccc(Nc2nc(=O)n(CCO)c(=O)n2Cc2ccc(Cl)cc2)cc1 InChI=1S/C21H23ClN4O4/c1-14(2)30-18-9-7-17(8-10-18)23-19-24-20(28)25(11-12-27)21(29)26(19)13-15-3-5-16(22)6-4-15/h3-10,14,27H,11-13H2,1-2H3,(H,23,24,28) WNEKFDBSKZECEH-UHFFFAOYSA-N 183160 US9150546, I-320::US9688643, I-320::US9718790, I-0320 P2X purinoceptor 3 Homo sapiens 83 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183160 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183160&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821401 313634560 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330954 CCCOc1ccc(Nc2nc(=O)n(CCO)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C21H22ClFN4O4/c1-2-11-31-18-8-7-16(12-17(18)23)24-19-25-20(29)26(9-10-28)21(30)27(19)13-14-3-5-15(22)6-4-14/h3-8,12,28H,2,9-11,13H2,1H3,(H,24,25,29) IAXQCPJUCZINLK-UHFFFAOYSA-N 183161 US9150546, I-321::US9688643, I-321::US9718790, I-0321 P2X purinoceptor 3 Homo sapiens 33 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183161 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183161&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821099 313634561 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330955 OCCn1c(=O)nc(Nc2ccc(OC3CCCC3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H25ClN4O4/c24-17-7-5-16(6-8-17)15-28-21(26-22(30)27(13-14-29)23(28)31)25-18-9-11-20(12-10-18)32-19-3-1-2-4-19/h5-12,19,29H,1-4,13-15H2,(H,25,26,30) QCYBCGKXTXODTF-UHFFFAOYSA-N 183162 US9150546, I-322::US9688643, I-322::US9718790, I-0322 P2X purinoceptor 3 Homo sapiens 112 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183162 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183162&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821323 313634562 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330956 CC(C)COc1ccc(Nc2nc(=O)n(CCO)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C22H24ClFN4O4/c1-14(2)13-32-19-8-7-17(11-18(19)24)25-20-26-21(30)27(9-10-29)22(31)28(20)12-15-3-5-16(23)6-4-15/h3-8,11,14,29H,9-10,12-13H2,1-2H3,(H,25,26,30) DCGRXCWZDNUUBX-UHFFFAOYSA-N 183163 US9150546, I-323::US9688643, I-323::US9718790, I-0323 P2X purinoceptor 3 Homo sapiens 148 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183163 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183163&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821442 313634563 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330957 OCCn1c(=O)nc(Nc2ccc(OC3CCOCC3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H25ClN4O5/c24-17-3-1-16(2-4-17)15-28-21(26-22(30)27(11-12-29)23(28)31)25-18-5-7-19(8-6-18)33-20-9-13-32-14-10-20/h1-8,20,29H,9-15H2,(H,25,26,30) KUNJUWMHHWZXFE-UHFFFAOYSA-N 183164 US9150546, I-324::US9688643, I-324::US9718790, I-0324 P2X purinoceptor 3 Homo sapiens 309 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183164 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183164&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821216 313634564 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330958 CC(C)Oc1ccc(Nc2nc(=O)n(CCO)c(=O)[nH]2)cc1F InChI=1S/C14H17FN4O4/c1-8(2)23-11-4-3-9(7-10(11)15)16-12-17-13(21)19(5-6-20)14(22)18-12/h3-4,7-8,20H,5-6H2,1-2H3,(H2,16,17,18,21,22) SIRUOEAXMZXYMV-UHFFFAOYSA-N 183165 US9150546, I-325::US9688643, I-325::US9718790, I-0325 P2X purinoceptor 3 Homo sapiens 665 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183165 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183165&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821351 313634565 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330959 CC(C)Oc1ccc(Nc2nc(=O)n(CCCNC(C)=O)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C24H27ClFN5O4/c1-15(2)35-21-10-9-19(13-20(21)26)28-22-29-23(33)30(12-4-11-27-16(3)32)24(34)31(22)14-17-5-7-18(25)8-6-17/h5-10,13,15H,4,11-12,14H2,1-3H3,(H,27,32)(H,28,29,33) IFZZAWGUWRJMDO-UHFFFAOYSA-N 183166 US9150546, I-326::US9688643, I-326::US9718790, I-0326 P2X purinoceptor 3 Homo sapiens 11 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183166 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183166&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821044 313634566 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330960 CC(C)Cc1ccc(Nc2nc(=O)n(CCO)c(=O)n2Cc2ccc(Cl)cc2)cc1 InChI=1S/C22H25ClN4O3/c1-15(2)13-16-5-9-19(10-6-16)24-20-25-21(29)26(11-12-28)22(30)27(20)14-17-3-7-18(23)8-4-17/h3-10,15,28H,11-14H2,1-2H3,(H,24,25,29) JJEVCTBXYVKJGJ-UHFFFAOYSA-N 183167 US9150546, I-328::US9688643, I-328::US9718790, I-0328 P2X purinoceptor 3 Homo sapiens 124 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183167 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183167&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821364 313634567 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330961 OCCn1c(=O)nc(Nc2ccc(OC(F)F)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C19H17ClF2N4O4/c20-13-3-1-12(2-4-13)11-26-17(24-18(28)25(9-10-27)19(26)29)23-14-5-7-15(8-6-14)30-16(21)22/h1-8,16,27H,9-11H2,(H,23,24,28) RKXQIFCQXRKXAA-UHFFFAOYSA-N 183168 US9150546, I-329::US9688643, I-329::US9718790, I-0329 P2X purinoceptor 3 Homo sapiens 266 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183168 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183168&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821162 313634568 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330962 OCCn1c(=O)nc(Nc2ccc(OCC#N)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C20H18ClN5O4/c21-15-3-1-14(2-4-15)13-26-18(24-19(28)25(10-11-27)20(26)29)23-16-5-7-17(8-6-16)30-12-9-22/h1-8,27H,10-13H2,(H,23,24,28) DAHFGHKKJUUEMZ-UHFFFAOYSA-N 183169 US9150546, I-330::US9688643, I-330::US9718790, I-0330 P2X purinoceptor 3 Homo sapiens 594 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183169 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183169&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821450 313634569 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330963 CC(C)Oc1ccc(Nc2nc(=O)n(CC(C)(C)CN)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C24H29ClFN5O3/c1-15(2)34-20-10-9-18(11-19(20)26)28-21-29-22(32)31(14-24(3,4)13-27)23(33)30(21)12-16-5-7-17(25)8-6-16/h5-11,15H,12-14,27H2,1-4H3,(H,28,29,32) KNTGWOHWZKIFHC-UHFFFAOYSA-N 183170 US9150546, I-331::US9688643, I-331::US9718790, I-0331 P2X purinoceptor 3 Homo sapiens 66 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183170 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183170&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821383 313634570 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330964 CC(C)Oc1ccc(Nc2nc(=O)n(CC(C)(C)CO)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C24H28ClFN4O4/c1-15(2)34-20-10-9-18(11-19(20)26)27-21-28-22(32)30(13-24(3,4)14-31)23(33)29(21)12-16-5-7-17(25)8-6-16/h5-11,15,31H,12-14H2,1-4H3,(H,27,28,32) HGRPNRICIGWDCD-UHFFFAOYSA-N 183171 US9150546, I-332::US9688643, I-332::US9718790, I-0332 P2X purinoceptor 3 Homo sapiens 8 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183171 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183171&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821434 313634571 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330965 CC(C)Oc1ccc(Nc2nc(=O)n(CCO)c(=O)n2Cc2ccc(F)cc2)cc1F InChI=1S/C21H22F2N4O4/c1-13(2)31-18-8-7-16(11-17(18)23)24-19-25-20(29)26(9-10-28)21(30)27(19)12-14-3-5-15(22)6-4-14/h3-8,11,13,28H,9-10,12H2,1-2H3,(H,24,25,29) UKLFEXAABNFJMM-UHFFFAOYSA-N 183172 US9150546, I-333::US9688643, I-333::US9718790, I-0333 P2X purinoceptor 3 Homo sapiens 192 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183172 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183172&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821111 313634572 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330966 OCCn1c(=O)nc(Nc2ccc(Oc3ccccc3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H21ClN4O4/c25-18-8-6-17(7-9-18)16-29-22(27-23(31)28(14-15-30)24(29)32)26-19-10-12-21(13-11-19)33-20-4-2-1-3-5-20/h1-13,30H,14-16H2,(H,26,27,31) KLZCINWURKWDQT-UHFFFAOYSA-N 183173 US9150546, I-334::US9688643, I-334::US9718790, I-0334 P2X purinoceptor 3 Homo sapiens 99 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183173 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183173&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76820945 313634573 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330967 CC(C)Oc1ccc(Nc2nc(=O)n(CC3(CO)CC3)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C24H26ClFN4O4/c1-15(2)34-20-8-7-18(11-19(20)26)27-21-28-22(32)30(13-24(14-31)9-10-24)23(33)29(21)12-16-3-5-17(25)6-4-16/h3-8,11,15,31H,9-10,12-14H2,1-2H3,(H,27,28,32) NHPKSMZBRJQQSF-UHFFFAOYSA-N 183174 US9150546, I-335::US9688643, I-335::US9718790, I-0335 P2X purinoceptor 3 Homo sapiens 7 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183174 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183174&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821197 313634574 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330968 COC(=O)Cn1c(=O)nc(Nc2ccc(OC(C)C)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C22H22ClFN4O5/c1-13(2)33-18-9-8-16(10-17(18)24)25-20-26-21(30)28(12-19(29)32-3)22(31)27(20)11-14-4-6-15(23)7-5-14/h4-10,13H,11-12H2,1-3H3,(H,25,26,30) FLNMUXWIGQAANO-UHFFFAOYSA-N 183175 US9150546, I-338::US9688643, I-338::US9718790, I-0338 P2X purinoceptor 3 Homo sapiens 53 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183175 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183175&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76820973 313634575 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330969 CC(C)Oc1ccc(Nc2nc(=O)n(CCO)c(=O)n2Cc2ccc(F)c(F)c2)cc1F InChI=1S/C21H21F3N4O4/c1-12(2)32-18-6-4-14(10-17(18)24)25-19-26-20(30)27(7-8-29)21(31)28(19)11-13-3-5-15(22)16(23)9-13/h3-6,9-10,12,29H,7-8,11H2,1-2H3,(H,25,26,30) CUQQYEWTZONCKB-UHFFFAOYSA-N 183176 US9150546, I-339::US9688643, I-339::US9718790, I-0339 P2X purinoceptor 3 Homo sapiens 775 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183176 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183176&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821332 313634576 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330970 CC(C)Oc1ccc(Nc2nc(=O)n(CCO)c(=O)n2Cc2ccc(F)cc2F)cc1F InChI=1S/C21H21F3N4O4/c1-12(2)32-18-6-5-15(10-17(18)24)25-19-26-20(30)27(7-8-29)21(31)28(19)11-13-3-4-14(22)9-16(13)23/h3-6,9-10,12,29H,7-8,11H2,1-2H3,(H,25,26,30) RTZOYNJXYRFCMD-UHFFFAOYSA-N 183177 US9150546, I-340::US9688643, I-340::US9718790, I-0340 P2X purinoceptor 3 Homo sapiens 336 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183177 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183177&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821109 313634577 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330971 CC(C)Oc1ccc(Nc2nc(=O)n(CCO)c(=O)n2Cc2ccc(Cl)c(F)c2)cc1F InChI=1S/C21H21ClF2N4O4/c1-12(2)32-18-6-4-14(10-17(18)24)25-19-26-20(30)27(7-8-29)21(31)28(19)11-13-3-5-15(22)16(23)9-13/h3-6,9-10,12,29H,7-8,11H2,1-2H3,(H,25,26,30) QSZIEXCHKXBPKQ-UHFFFAOYSA-N 183178 US9150546, I-341::US9688643, I-341::US9718790, I-0341 P2X purinoceptor 3 Homo sapiens 149 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183178 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183178&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821011 313634578 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330972 CC(C)Oc1ccc(Nc2nc(=O)n(CCCOC3CCCCO3)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C27H32ClFN4O5/c1-18(2)38-23-12-11-21(16-22(23)29)30-25-31-26(34)32(13-5-15-37-24-6-3-4-14-36-24)27(35)33(25)17-19-7-9-20(28)10-8-19/h7-12,16,18,24H,3-6,13-15,17H2,1-2H3,(H,30,31,34) PZPBYNVUKMXYIV-UHFFFAOYSA-N 183179 US9150546, I-342::US9688643, I-342::US9718790, I-0342 P2X purinoceptor 3 Homo sapiens 5 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183179 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183179&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821045 313634579 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330973 COc1ccc(Cn2c(=O)nc(Nc3ccc(OC(C)C)c(F)c3)n(Cc3ccc(Cl)cc3)c2=O)cc1 InChI=1S/C27H26ClFN4O4/c1-17(2)37-24-13-10-21(14-23(24)29)30-25-31-26(34)33(16-19-6-11-22(36-3)12-7-19)27(35)32(25)15-18-4-8-20(28)9-5-18/h4-14,17H,15-16H2,1-3H3,(H,30,31,34) JVNJNDPHOPMJGS-UHFFFAOYSA-N 183180 US9150546, I-343::US9688643, I-343::US9718790, I-0343 P2X purinoceptor 3 Homo sapiens 21 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183180 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183180&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821071 313634580 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330974 CCCCc1ccc(Nc2nc(=O)n(CCO)c(=O)n2Cc2ccc(Cl)cc2)cc1 InChI=1S/C22H25ClN4O3/c1-2-3-4-16-7-11-19(12-8-16)24-20-25-21(29)26(13-14-28)22(30)27(20)15-17-5-9-18(23)10-6-17/h5-12,28H,2-4,13-15H2,1H3,(H,24,25,29) NFHXSNPUKNDNLC-UHFFFAOYSA-N 183181 US9150546, I-344::US9688643, I-344::US9718790, I-0344 P2X purinoceptor 3 Homo sapiens 128 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183181 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183181&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821446 313634581 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330975 CC(C)Oc1ccc(Nc2nc(=O)n(CC=C)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C22H22ClFN4O3/c1-4-11-27-21(29)26-20(25-17-9-10-19(18(24)12-17)31-14(2)3)28(22(27)30)13-15-5-7-16(23)8-6-15/h4-10,12,14H,1,11,13H2,2-3H3,(H,25,26,29) KVIXRQVJVQCDSK-UHFFFAOYSA-N 183182 US9150546, I-346::US9688643, I-346::US9718790, I-0346 P2X purinoceptor 3 Homo sapiens 16 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183182 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183182&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821368 313634582 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330976 CC(C)Oc1ccc(Nc2nc(=O)n(CCO)c(=O)n2Cc2ccc(cc2)[N+]([O-])=O)cc1F InChI=1S/C21H22FN5O6/c1-13(2)33-18-8-5-15(11-17(18)22)23-19-24-20(29)25(9-10-28)21(30)26(19)12-14-3-6-16(7-4-14)27(31)32/h3-8,11,13,28H,9-10,12H2,1-2H3,(H,23,24,29) VPITVNBBSGONIS-UHFFFAOYSA-N 183183 US9150546, I-347::US9688643, I-347::US9718790, I-0347 P2X purinoceptor 3 Homo sapiens 251 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183183 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183183&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821178 313634583 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330977 CCCn1c(=O)nc(Nc2ccc(OC(C)C)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C22H24ClFN4O3/c1-4-11-27-21(29)26-20(25-17-9-10-19(18(24)12-17)31-14(2)3)28(22(27)30)13-15-5-7-16(23)8-6-15/h5-10,12,14H,4,11,13H2,1-3H3,(H,25,26,29) JPYJUMSFDCRFTJ-UHFFFAOYSA-N 183184 US9150546, I-348::US9688643, I-348::US9718790, I-0348 P2X purinoceptor 3 Homo sapiens 13 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183184 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183184&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821127 313634584 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330978 CCCn1c(=O)nc(Nc2ccc(OC(C)C)c(F)c2)n(Cc2ccccc2)c1=O InChI=1S/C22H25FN4O3/c1-4-12-26-21(28)25-20(27(22(26)29)14-16-8-6-5-7-9-16)24-17-10-11-19(18(23)13-17)30-15(2)3/h5-11,13,15H,4,12,14H2,1-3H3,(H,24,25,28) QOJKTYIYEBVLFQ-UHFFFAOYSA-N 183185 US9150546, I-349::US9688643, I-349::US9718790, I-0349 P2X purinoceptor 3 Homo sapiens 113 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183185 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183185&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821075 313634585 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330979 CC(C)Oc1ccc(Nc2nc(=O)n(CCOC3CCCCO3)c(=O)n2Cc2ccc(Cl)cc2)cc1Cl InChI=1S/C26H30Cl2N4O5/c1-17(2)37-22-11-10-20(15-21(22)28)29-24-30-25(33)31(12-14-36-23-5-3-4-13-35-23)26(34)32(24)16-18-6-8-19(27)9-7-18/h6-11,15,17,23H,3-5,12-14,16H2,1-2H3,(H,29,30,33) HYEDLAYHBGAJBN-UHFFFAOYSA-N 183186 US9150546, I-350::US9688643, I-350::US9718790, I-0350 P2X purinoceptor 3 Homo sapiens 10 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183186 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183186&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821217 313634586 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330980 CC(C)Oc1ccc(Nc2nc(=O)n(CCO)c(=O)n2Cc2ccc(Cl)cc2)cc1Cl InChI=1S/C21H22Cl2N4O4/c1-13(2)31-18-8-7-16(11-17(18)23)24-19-25-20(29)26(9-10-28)21(30)27(19)12-14-3-5-15(22)6-4-14/h3-8,11,13,28H,9-10,12H2,1-2H3,(H,24,25,29) LVLPRWHJRHKWQM-UHFFFAOYSA-N 183187 US9150546, I-351::US9688643, I-351::US9718790, I-0351 P2X purinoceptor 3 Homo sapiens 15 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183187 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183187&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821305 313634587 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330981 CC(C)Oc1ccc(Nc2nc(=O)n(CCC(=O)NCCO)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C24H27ClFN5O5/c1-15(2)36-20-8-7-18(13-19(20)26)28-22-29-23(34)30(11-9-21(33)27-10-12-32)24(35)31(22)14-16-3-5-17(25)6-4-16/h3-8,13,15,32H,9-12,14H2,1-2H3,(H,27,33)(H,28,29,34) CWCRNKZFRUTYCW-UHFFFAOYSA-N 183188 US9150546, I-352::US9688643, I-352::US9718790, I-0352 P2X purinoceptor 3 Homo sapiens 36 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183188 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183188&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821100 313634588 C04080 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330982 CC(C)Oc1ccc(Nc2nc(=O)n(CC(=O)NCCO)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C23H25ClFN5O5/c1-14(2)35-19-8-7-17(11-18(19)25)27-21-28-22(33)30(13-20(32)26-9-10-31)23(34)29(21)12-15-3-5-16(24)6-4-15/h3-8,11,14,31H,9-10,12-13H2,1-2H3,(H,26,32)(H,27,28,33) ORMVFHWWSZHFJA-UHFFFAOYSA-N 183189 US9150546, I-353::US9688643, I-353::US9718790, I-0353 P2X purinoceptor 3 Homo sapiens 18 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183189 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183189&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 77888221 313634589 C04080 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330983 CCOC(=O)CCn1c(=O)nc(Nc2ccc(OC(C)C)c(Cl)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H26Cl2N4O5/c1-4-34-21(31)11-12-29-23(32)28-22(27-18-9-10-20(19(26)13-18)35-15(2)3)30(24(29)33)14-16-5-7-17(25)8-6-16/h5-10,13,15H,4,11-12,14H2,1-3H3,(H,27,28,32) VHGWQSUSWLECNQ-UHFFFAOYSA-N 183190 US9150546, I-354::US9688643, I-354::US9718790, I-0354 P2X purinoceptor 3 Homo sapiens 8 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183190 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183190&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821037 313634590 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330984 CC(C)Oc1ccc(Nc2nc(=O)n(CCC(O)=O)c(=O)n2Cc2ccc(Cl)cc2)cc1Cl InChI=1S/C22H22Cl2N4O5/c1-13(2)33-18-8-7-16(11-17(18)24)25-20-26-21(31)27(10-9-19(29)30)22(32)28(20)12-14-3-5-15(23)6-4-14/h3-8,11,13H,9-10,12H2,1-2H3,(H,29,30)(H,25,26,31) LTHMPYWKRCESAL-UHFFFAOYSA-N 183191 US9150546, I-355::US9688643, I-355::US9718790, I-0355 P2X purinoceptor 3 Homo sapiens 20 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183191 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183191&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821101 313634591 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330985 CCOC(=O)CCn1c(=O)nc(Nc2ccc(OC(C)C)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H26ClFN4O5/c1-4-34-21(31)11-12-29-23(32)28-22(27-18-9-10-20(19(26)13-18)35-15(2)3)30(24(29)33)14-16-5-7-17(25)8-6-16/h5-10,13,15H,4,11-12,14H2,1-3H3,(H,27,28,32) LDMWUXAYSNMZOT-UHFFFAOYSA-N 183192 US9150546, I-356::US9688643, I-356::US9718790, I-0356 P2X purinoceptor 3 Homo sapiens 12 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183192 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183192&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821391 313634592 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330986 OCCCn1c(=O)nc(Nc2cccc(c2)C(F)(F)F)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C20H18ClF3N4O3/c21-15-7-5-13(6-8-15)12-28-17(26-18(30)27(19(28)31)9-2-10-29)25-16-4-1-3-14(11-16)20(22,23)24/h1,3-8,11,29H,2,9-10,12H2,(H,25,26,30) DOVAEUUVRWPLHI-UHFFFAOYSA-N 183193 US9150546, I-357::US9688643, I-357::US9718790, I-0357 P2X purinoceptor 3 Homo sapiens 47 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183193 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183193&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821023 313634593 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330987 CC(C)Cc1ccc(Nc2nc(=O)n(CCCO)c(=O)n2Cc2ccc(Cl)cc2)cc1 InChI=1S/C23H27ClN4O3/c1-16(2)14-17-6-10-20(11-7-17)25-21-26-22(30)27(12-3-13-29)23(31)28(21)15-18-4-8-19(24)9-5-18/h4-11,16,29H,3,12-15H2,1-2H3,(H,25,26,30) KQESQAJPTWDTMT-UHFFFAOYSA-N 183194 US9150546, I-358::US9688643, I-358::US9718790, I-0358 P2X purinoceptor 3 Homo sapiens 55 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183194 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183194&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821234 313634594 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330988 CC(C)Oc1ccc(Nc2nc(=O)n(CCCO)c(=O)n2Cc2ccc(Cl)cc2)cc1 InChI=1S/C22H25ClN4O4/c1-15(2)31-19-10-8-18(9-11-19)24-20-25-21(29)26(12-3-13-28)22(30)27(20)14-16-4-6-17(23)7-5-16/h4-11,15,28H,3,12-14H2,1-2H3,(H,24,25,29) XMOQRFWNARHCLH-UHFFFAOYSA-N 183195 US9150546, I-359::US9688643, I-359::US9718790, I-0359 P2X purinoceptor 3 Homo sapiens 40 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183195 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183195&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821252 313634595 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330989 OCCCn1c(=O)nc(Nc2ccc(OC(F)F)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C20H19ClF2N4O4/c21-14-4-2-13(3-5-14)12-27-18(25-19(29)26(20(27)30)10-1-11-28)24-15-6-8-16(9-7-15)31-17(22)23/h2-9,17,28H,1,10-12H2,(H,24,25,29) YRRWZMDHZPCEJW-UHFFFAOYSA-N 183196 US9150546, I-360::US9688643, I-360::US9718790, I-0360 P2X purinoceptor 3 Homo sapiens 148 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183196 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183196&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821343 313634596 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330990 CCOc1ccc(Nc2nc(=O)n(CCCO)c(=O)n2Cc2ccc(Cl)cc2)cc1 InChI=1S/C21H23ClN4O4/c1-2-30-18-10-8-17(9-11-18)23-19-24-20(28)25(12-3-13-27)21(29)26(19)14-15-4-6-16(22)7-5-15/h4-11,27H,2-3,12-14H2,1H3,(H,23,24,28) MQGOIKGFIRWKLK-UHFFFAOYSA-N 183197 US9150546, I-361::US9688643, I-361::US9718790, I-0361 P2X purinoceptor 3 Homo sapiens 76 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183197 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183197&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821375 313634597 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330991 CC(C)Oc1ccc(Nc2nc(=O)n(CCCO)c(=O)n2Cc2ccc(Cl)cc2)cc1Cl InChI=1S/C22H24Cl2N4O4/c1-14(2)32-19-9-8-17(12-18(19)24)25-20-26-21(30)27(10-3-11-29)22(31)28(20)13-15-4-6-16(23)7-5-15/h4-9,12,14,29H,3,10-11,13H2,1-2H3,(H,25,26,30) CGVREEYRNJNDLQ-UHFFFAOYSA-N 183198 US9150546, I-362::US9688643, I-362::US9718790, I-0362 P2X purinoceptor 3 Homo sapiens 7 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183198 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183198&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821189 313634598 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330992 CC(C)Oc1ccc(Nc2nc(=O)n(CCCC(O)=O)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C23H24ClFN4O5/c1-14(2)34-19-10-9-17(12-18(19)25)26-21-27-22(32)28(11-3-4-20(30)31)23(33)29(21)13-15-5-7-16(24)8-6-15/h5-10,12,14H,3-4,11,13H2,1-2H3,(H,30,31)(H,26,27,32) PRGQUPCLZCUZSW-UHFFFAOYSA-N 183199 US9150546, I-363::US9688643, I-363::US9718790, I-0363 P2X purinoceptor 3 Homo sapiens 78 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183199 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183199&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821307 313634599 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330993 CC(C)Oc1ccc(Nc2nc(=O)n(CC(C)(C)C(O)=O)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C24H26ClFN4O5/c1-14(2)35-19-10-9-17(11-18(19)26)27-21-28-22(33)30(13-24(3,4)20(31)32)23(34)29(21)12-15-5-7-16(25)8-6-15/h5-11,14H,12-13H2,1-4H3,(H,31,32)(H,27,28,33) CAYYASMSWISXDA-UHFFFAOYSA-N 183200 US9150546, I-364::US9688643, I-364::US9718790, I-0364 P2X purinoceptor 3 Homo sapiens 30 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183200 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183200&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821363 313634600 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330994 CC(C)Oc1ccc(Nc2nc(=O)n(CCCCO)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C23H26ClFN4O4/c1-15(2)33-20-10-9-18(13-19(20)25)26-21-27-22(31)28(11-3-4-12-30)23(32)29(21)14-16-5-7-17(24)8-6-16/h5-10,13,15,30H,3-4,11-12,14H2,1-2H3,(H,26,27,31) WIVQLHRBUYZELM-UHFFFAOYSA-N 183201 US9150546, I-365::US9688643, I-365::US9718790, I-0365 P2X purinoceptor 3 Homo sapiens 18 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183201 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183201&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821405 313634601 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330995 CC(C)Cc1ccc(Nc2nc(=O)n(CC(CO)CO)c(=O)n2Cc2ccc(Cl)cc2)cc1 InChI=1S/C24H29ClN4O4/c1-16(2)11-17-5-9-21(10-6-17)26-22-27-23(32)29(13-19(14-30)15-31)24(33)28(22)12-18-3-7-20(25)8-4-18/h3-10,16,19,30-31H,11-15H2,1-2H3,(H,26,27,32) DKYDIWXEJZFVMN-UHFFFAOYSA-N 183202 US9150546, I-366::US9688643, I-366::US9718790, I-0366 P2X purinoceptor 3 Homo sapiens 46 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183202 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183202&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821182 313634602 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330996 OCC(CO)Cn1c(=O)nc(Nc2cccc(c2)C(F)(F)F)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C21H20ClF3N4O4/c22-16-6-4-13(5-7-16)9-28-18(26-17-3-1-2-15(8-17)21(23,24)25)27-19(32)29(20(28)33)10-14(11-30)12-31/h1-8,14,30-31H,9-12H2,(H,26,27,32) KCPABKMRFNAYPP-UHFFFAOYSA-N 183203 US9150546, I-367::US9688643, I-367::US9718790, I-0367 P2X purinoceptor 3 Homo sapiens 40 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183203 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183203&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821236 313634603 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330997 CC(C)Oc1ccc(Nc2nc(=O)n(CC(CO)CO)c(=O)n2Cc2ccc(Cl)cc2)cc1 InChI=1S/C23H27ClN4O5/c1-15(2)33-20-9-7-19(8-10-20)25-21-26-22(31)28(12-17(13-29)14-30)23(32)27(21)11-16-3-5-18(24)6-4-16/h3-10,15,17,29-30H,11-14H2,1-2H3,(H,25,26,31) RWDNKWAXZYGNOK-UHFFFAOYSA-N 183204 US9150546, I-368::US9688643, I-368::US9718790, I-0368 P2X purinoceptor 3 Homo sapiens 41 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183204 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183204&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821424 313634604 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330998 CC(C)Oc1ccc(Nc2nc(=O)n(CC(CO)CO)c(=O)n2Cc2ccc(Cl)cc2)cc1Cl InChI=1S/C23H26Cl2N4O5/c1-14(2)34-20-8-7-18(9-19(20)25)26-21-27-22(32)29(11-16(12-30)13-31)23(33)28(21)10-15-3-5-17(24)6-4-15/h3-9,14,16,30-31H,10-13H2,1-2H3,(H,26,27,32) PLKBMAZPUXNVOD-UHFFFAOYSA-N 183205 US9150546, I-369::US9688643, I-369::US9718790, I-0369 P2X purinoceptor 3 Homo sapiens 7 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183205 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183205&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821090 313634605 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 330999 OCC(CO)Cn1c(=O)nc(Nc2ccc(OC(F)F)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C21H21ClF2N4O5/c22-15-3-1-13(2-4-15)9-27-19(25-16-5-7-17(8-6-16)33-18(23)24)26-20(31)28(21(27)32)10-14(11-29)12-30/h1-8,14,18,29-30H,9-12H2,(H,25,26,31) ZMQLRXDQQRWLTK-UHFFFAOYSA-N 183206 US9150546, I-370::US9688643, I-370::US9718790, I-0370 P2X purinoceptor 3 Homo sapiens 154 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183206 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183206&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821298 313634606 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331000 CCOc1ccc(Nc2nc(=O)n(CC(CO)CO)c(=O)n2Cc2ccc(Cl)cc2)cc1 InChI=1S/C22H25ClN4O5/c1-2-32-19-9-7-18(8-10-19)24-20-25-21(30)27(12-16(13-28)14-29)22(31)26(20)11-15-3-5-17(23)6-4-15/h3-10,16,28-29H,2,11-14H2,1H3,(H,24,25,30) YVGBOPHKOBITOP-UHFFFAOYSA-N 183207 US9150546, I-371::US9688643, I-371::US9718790, I-0371 P2X purinoceptor 3 Homo sapiens 63 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183207 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183207&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821436 313634607 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331001 CC(C)n1c(=O)nc(Nc2ccc(cc2)C#N)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C20H18ClN5O2/c1-13(2)26-19(27)24-18(23-17-9-5-14(11-22)6-10-17)25(20(26)28)12-15-3-7-16(21)8-4-15/h3-10,13H,12H2,1-2H3,(H,23,24,27) NZRBAYNKFGYVJA-UHFFFAOYSA-N 183208 US9150546, I-372::US9688643, I-372::US9718790, I-0372 P2X purinoceptor 3 Homo sapiens 964 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183208 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183208&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821062 313634608 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331002 OCCn1c(=O)nc(Nc2ccc(Cl)c(Cl)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C18H15Cl3N4O3/c19-12-3-1-11(2-4-12)10-25-16(22-13-5-6-14(20)15(21)9-13)23-17(27)24(7-8-26)18(25)28/h1-6,9,26H,7-8,10H2,(H,22,23,27) TYTCSKQWLRQJSW-UHFFFAOYSA-N 183209 US9150546, I-373::US9688643, I-373::US9718790, I-0373 P2X purinoceptor 3 Homo sapiens 185 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183209 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183209&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821272 313634609 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331003 OCCn1c(=O)nc(Nc2ccc(OC3CCCC3)c(Cl)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H24Cl2N4O4/c24-16-7-5-15(6-8-16)14-29-21(27-22(31)28(11-12-30)23(29)32)26-17-9-10-20(19(25)13-17)33-18-3-1-2-4-18/h5-10,13,18,30H,1-4,11-12,14H2,(H,26,27,31) DLYUERWZMWXDRU-UHFFFAOYSA-N 183210 US9150546, I-374::US9688643, I-374::US9718790, I-0374 P2X purinoceptor 3 Homo sapiens 80 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183210 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183210&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821239 313634610 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331004 OCCn1c(=O)nc(Nc2ccc(OC(F)F)c(Cl)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C19H16Cl2F2N4O4/c20-12-3-1-11(2-4-12)10-27-17(25-18(29)26(7-8-28)19(27)30)24-13-5-6-15(14(21)9-13)31-16(22)23/h1-6,9,16,28H,7-8,10H2,(H,24,25,29) YCBOZBOYAOUFQO-UHFFFAOYSA-N 183211 US9150546, I-375::US9688643, I-375::US9718790, I-0375 P2X purinoceptor 3 Homo sapiens 152 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183211 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183211&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821378 313634611 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331005 CS(=O)(=O)Nc1ccc(Nc2nc(=O)n(CCO)c(=O)n2Cc2ccc(Cl)cc2)cc1 InChI=1S/C19H20ClN5O5S/c1-31(29,30)23-16-8-6-15(7-9-16)21-17-22-18(27)24(10-11-26)19(28)25(17)12-13-2-4-14(20)5-3-13/h2-9,23,26H,10-12H2,1H3,(H,21,22,27) GOQQKNNSEKHBIT-UHFFFAOYSA-N 183212 US9150546, I-377::US9718790, I-0377 P2X purinoceptor 3 Homo sapiens 755 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183212 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183212&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 77388326 313634612 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331006 CC(C)c1cccc(Nc2nc(=O)n(CCO)c(=O)n2Cc2ccc(Cl)cc2)c1 InChI=1S/C21H23ClN4O3/c1-14(2)16-4-3-5-18(12-16)23-19-24-20(28)25(10-11-27)21(29)26(19)13-15-6-8-17(22)9-7-15/h3-9,12,14,27H,10-11,13H2,1-2H3,(H,23,24,28) HHUYYWJOWGZXNS-UHFFFAOYSA-N 183213 US9150546, I-378::US9688643, I-378::US9718790, I-0378 P2X purinoceptor 3 Homo sapiens 347 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183213 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183213&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821174 313634613 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331007 CCCSc1ccc(Nc2nc(=O)n(CCO)c(=O)n2Cc2ccc(Cl)cc2)cc1 InChI=1S/C21H23ClN4O3S/c1-2-13-30-18-9-7-17(8-10-18)23-19-24-20(28)25(11-12-27)21(29)26(19)14-15-3-5-16(22)6-4-15/h3-10,27H,2,11-14H2,1H3,(H,23,24,28) WSXYIBMUMGPQNK-UHFFFAOYSA-N 183214 US9150546, I-379::US9688643, I-379::US9718790, I-0379 P2X purinoceptor 3 Homo sapiens 330 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183214 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183214&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821173 313634614 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331008 CCOC(=O)CCn1c(=O)nc(Nc2ccc(OC(C)C)c(Cl)c2)n(CC2CCCCC2)c1=O InChI=1S/C24H33ClN4O5/c1-4-33-21(30)12-13-28-23(31)27-22(29(24(28)32)15-17-8-6-5-7-9-17)26-18-10-11-20(19(25)14-18)34-16(2)3/h10-11,14,16-17H,4-9,12-13,15H2,1-3H3,(H,26,27,31) NMXZCGVWTFHWPD-UHFFFAOYSA-N 183215 US9150546, I-380::US9688643, I-380::US9718790, I-0380 P2X purinoceptor 3 Homo sapiens 34 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183215 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183215&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821211 313634615 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331009 CC(C)Oc1ccc(Nc2nc(=O)n(CCC(O)=O)c(=O)n2CC2CCCCC2)cc1Cl InChI=1S/C22H29ClN4O5/c1-14(2)32-18-9-8-16(12-17(18)23)24-20-25-21(30)26(11-10-19(28)29)22(31)27(20)13-15-6-4-3-5-7-15/h8-9,12,14-15H,3-7,10-11,13H2,1-2H3,(H,28,29)(H,24,25,30) QKIBFGFDLISDQM-UHFFFAOYSA-N 183216 US9150546, I-382::US9688643, I-382::US9718790, I-0382 P2X purinoceptor 3 Homo sapiens 96 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183216 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183216&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821152 313634616 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331010 OCCn1c(=O)nc(Nc2ccc(OC(F)(F)F)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C19H16ClF3N4O4/c20-13-3-1-12(2-4-13)11-27-16(25-17(29)26(9-10-28)18(27)30)24-14-5-7-15(8-6-14)31-19(21,22)23/h1-8,28H,9-11H2,(H,24,25,29) SPZDSFVDXNQRAX-UHFFFAOYSA-N 183217 US9150546, I-383::US9688643, I-383::US9718790, I-0383 P2X purinoceptor 3 Homo sapiens 532 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183217 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183217&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821098 313634617 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331011 CCCS(=O)c1ccc(Nc2nc(=O)n(CCO)c(=O)n2Cc2ccc(Cl)cc2)cc1 InChI=1S/C21H23ClN4O4S/c1-2-13-31(30)18-9-7-17(8-10-18)23-19-24-20(28)25(11-12-27)21(29)26(19)14-15-3-5-16(22)6-4-15/h3-10,27H,2,11-14H2,1H3,(H,23,24,28) OTAYHRITIADLTG-UHFFFAOYSA-N 183218 US9150546, I-385::US9688643, I-385::US9718790, I-0385 P2X purinoceptor 3 Homo sapiens 908 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183218 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183218&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821286 313634618 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331012 CC(C)Oc1ccc(Nc2nc(=O)n(CCNC(N)=O)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C22H24ClFN6O4/c1-13(2)34-18-8-7-16(11-17(18)24)27-20-28-21(32)29(10-9-26-19(25)31)22(33)30(20)12-14-3-5-15(23)6-4-14/h3-8,11,13H,9-10,12H2,1-2H3,(H3,25,26,31)(H,27,28,32) WGRJWKPPVJDRMX-UHFFFAOYSA-N 183219 US9150546, I-386::US9688643, I-386::US9718790, I-0386 P2X purinoceptor 3 Homo sapiens 41 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183219 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183219&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 77888201 313634619 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331013 CNC(=O)NCCn1c(=O)nc(Nc2ccc(OC(C)C)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H26ClFN6O4/c1-14(2)35-19-9-8-17(12-18(19)25)28-20-29-22(33)30(11-10-27-21(32)26-3)23(34)31(20)13-15-4-6-16(24)7-5-15/h4-9,12,14H,10-11,13H2,1-3H3,(H2,26,27,32)(H,28,29,33) GBKQOARKSUDDPS-UHFFFAOYSA-N 183220 US9150546, I-387::US9688643, I-387::US9718790, I-0387 P2X purinoceptor 3 Homo sapiens 37 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183220 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183220&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 77387734 313634620 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331014 CC(C)Oc1ccc(Nc2nc(=O)n(CCNC(=O)N(C)C)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C24H28ClFN6O4/c1-15(2)36-20-10-9-18(13-19(20)26)28-21-29-23(34)31(12-11-27-22(33)30(3)4)24(35)32(21)14-16-5-7-17(25)8-6-16/h5-10,13,15H,11-12,14H2,1-4H3,(H,27,33)(H,28,29,34) LQVUMSPACOUIKQ-UHFFFAOYSA-N 183221 US9150546, I-388::US9688643, I-388::US9718790, I-0388 P2X purinoceptor 3 Homo sapiens 36 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183221 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183221&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 77888222 313634621 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331015 CCNC(=O)NCCn1c(=O)nc(Nc2ccc(OC(C)C)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H28ClFN6O4/c1-4-27-22(33)28-11-12-31-23(34)30-21(29-18-9-10-20(19(26)13-18)36-15(2)3)32(24(31)35)14-16-5-7-17(25)8-6-16/h5-10,13,15H,4,11-12,14H2,1-3H3,(H2,27,28,33)(H,29,30,34) OPMCGYFGAQSGMM-UHFFFAOYSA-N 183222 US9150546, I-389::US9688643, I-389::US9718790, I-0389 P2X purinoceptor 3 Homo sapiens 64 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183222 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183222&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 77387733 313634622 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331016 CC(C)Oc1ccc(Nc2nc(=O)n(CCNC(=O)NCCO)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C24H28ClFN6O5/c1-15(2)37-20-8-7-18(13-19(20)26)29-21-30-23(35)31(11-9-27-22(34)28-10-12-33)24(36)32(21)14-16-3-5-17(25)6-4-16/h3-8,13,15,33H,9-12,14H2,1-2H3,(H2,27,28,34)(H,29,30,35) UYTSYZVVZRWWPG-UHFFFAOYSA-N 183223 US9150546, I-390::US9688643, I-390::US9718790, I-0390 P2X purinoceptor 3 Homo sapiens 67 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183223 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183223&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 77888253 313634623 C04080 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331017 CC(C)Oc1ccc(Nc2nc(=O)n(CCN3C(=O)CNC3=O)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C24H24ClFN6O5/c1-14(2)37-19-8-7-17(11-18(19)26)28-21-29-23(35)31(10-9-30-20(33)12-27-22(30)34)24(36)32(21)13-15-3-5-16(25)6-4-15/h3-8,11,14H,9-10,12-13H2,1-2H3,(H,27,34)(H,28,29,35) VXBIJNZVTIYGOG-UHFFFAOYSA-N 183224 US9150546, I-391::US9688643, I-391::US9718790, I-0391 P2X purinoceptor 3 Homo sapiens 133 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183224 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183224&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821069 313634624 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331018 CC(C)Oc1ccc(Nc2nc(=O)n(CCNC(=O)NCC(O)=O)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C24H26ClFN6O6/c1-14(2)38-19-8-7-17(11-18(19)26)29-21-30-23(36)31(10-9-27-22(35)28-12-20(33)34)24(37)32(21)13-15-3-5-16(25)6-4-15/h3-8,11,14H,9-10,12-13H2,1-2H3,(H,33,34)(H2,27,28,35)(H,29,30,36) DNZVQLZWGVMZRF-UHFFFAOYSA-N 183225 US9150546, I-392::US9688643, I-392::US9718790, I-0392 P2X purinoceptor 3 Homo sapiens 38 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183225 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183225&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 77388921 313634625 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331019 CC(C)Oc1ccc(Nc2nc(=O)n(C(C)C)c(=O)n2Cc2ccc(Cl)cc2)cn1 InChI=1S/C21H24ClN5O3/c1-13(2)27-20(28)25-19(24-17-9-10-18(23-11-17)30-14(3)4)26(21(27)29)12-15-5-7-16(22)8-6-15/h5-11,13-14H,12H2,1-4H3,(H,24,25,28) ADLQECFGSXQFRO-UHFFFAOYSA-N 183226 US9150546, I-394::US9688643, I-394::US9718790, I-0394 P2X purinoceptor 3 Homo sapiens 435 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183226 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183226&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821185 313634626 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331020 COC(=O)CNC(=O)Cn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H25ClFN5O6/c1-14(2)37-19-9-8-17(10-18(19)26)28-22-29-23(34)31(13-20(32)27-11-21(33)36-3)24(35)30(22)12-15-4-6-16(25)7-5-15/h4-10,14H,11-13H2,1-3H3,(H,27,32)(H,28,29,34) RNYCCLDACFSVPF-UHFFFAOYSA-N 183227 US9150546, I-397::US9688643, I-397::US9718790, I-0396 P2X purinoceptor 3 Homo sapiens 19 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183227 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183227&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 70645186 313634627 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331021 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n(CC(=O)NC(CO)CO)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C24H27ClFN5O6/c1-14(2)37-20-8-7-17(9-19(20)26)28-22-29-23(35)31(11-21(34)27-18(12-32)13-33)24(36)30(22)10-15-3-5-16(25)6-4-15/h3-9,14,18,32-33H,10-13H2,1-2H3,(H,27,34)(H,28,29,35) QLEUXCJJSFSQEI-UHFFFAOYSA-N 183228 US9150546, I-398::US9688643, I-398::US9718790, I-0397 P2X purinoceptor 3 Homo sapiens 7 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183228 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183228&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 70645174 313634628 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331022 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(Cl)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H28Cl2N4O5/c1-15(2)36-20-11-10-18(12-19(20)27)28-22-29-23(33)31(14-25(3,4)21(32)35-5)24(34)30(22)13-16-6-8-17(26)9-7-16/h6-12,15H,13-14H2,1-5H3,(H,28,29,33) NEGZBMXAYHSDHD-UHFFFAOYSA-N 183229 US9150546, I-399::US9688643, I-399::US9718790, I-0398 P2X purinoceptor 3 Homo sapiens 8 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183229 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183229&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578721 313634629 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331023 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n(CC(=O)NCC(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C23H23ClFN5O6/c1-13(2)36-18-8-7-16(9-17(18)25)27-21-28-22(34)30(12-19(31)26-10-20(32)33)23(35)29(21)11-14-3-5-15(24)6-4-14/h3-9,13H,10-12H2,1-2H3,(H,26,31)(H,32,33)(H,27,28,34) YMEDLYRRZUJVPG-UHFFFAOYSA-N 183230 US9150546, I-400::US9688643, I-400::US9718790, I-0399 P2X purinoceptor 3 Homo sapiens 44 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183230 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183230&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 70645141 313634630 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331024 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C24H26Cl2N4O5/c1-14(2)35-19-10-9-17(11-18(19)26)27-21-28-22(33)30(13-24(3,4)20(31)32)23(34)29(21)12-15-5-7-16(25)8-6-15/h5-11,14H,12-13H2,1-4H3,(H,31,32)(H,27,28,33) JBUWYWPQCDLCBD-UHFFFAOYSA-N 183231 US9150546, I-401::US9688643, I-401::US9718790, I-0400 P2X purinoceptor 3 Homo sapiens 7 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183231 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183231&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578683 313634631 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331025 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(cc2)C(=O)C(C)(C)C)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C27H31ClN4O5/c1-26(2,3)21(33)18-9-13-20(14-10-18)29-23-30-24(35)32(16-27(4,5)22(34)37-6)25(36)31(23)15-17-7-11-19(28)12-8-17/h7-14H,15-16H2,1-6H3,(H,29,30,35) SNQFHIXRJZIARK-UHFFFAOYSA-N 183232 US9150546, I-402::US9688643, I-402::US9718790, I-0401 P2X purinoceptor 3 Homo sapiens 443 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183232 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183232&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578510 313634632 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331026 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H28ClFN4O5/c1-15(2)36-20-11-10-18(12-19(20)27)28-22-29-23(33)31(14-25(3,4)21(32)35-5)24(34)30(22)13-16-6-8-17(26)9-7-16/h6-12,15H,13-14H2,1-5H3,(H,28,29,33) HZQKRSDENBOLOY-UHFFFAOYSA-N 183233 US9150546, I-403::US9688643, I-403::US9718790, I-0402 P2X purinoceptor 3 Homo sapiens 15 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183233 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183233&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578492 313634633 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331027 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(F)c2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C26H31FN4O5/c1-16(2)36-21-12-11-19(13-20(21)27)28-23-29-24(33)31(15-26(4,5)22(32)35-6)25(34)30(23)14-18-9-7-17(3)8-10-18/h7-13,16H,14-15H2,1-6H3,(H,28,29,33) MRSBPJQMAXBIJN-UHFFFAOYSA-N 183234 US9150546, I-404::US9688643, I-404::US9718790, I-0403 P2X purinoceptor 3 Homo sapiens 12 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183234 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183234&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578473 313634634 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331028 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n1Cc1ccc(C)cc1 InChI=1S/C25H29FN4O5/c1-15(2)35-20-11-10-18(12-19(20)26)27-22-28-23(33)30(14-25(4,5)21(31)32)24(34)29(22)13-17-8-6-16(3)7-9-17/h6-12,15H,13-14H2,1-5H3,(H,31,32)(H,27,28,33) LJWOBZNJMCMRLJ-UHFFFAOYSA-N 183235 US9150546, I-405::US9688643, I-405::US9718790, I-0404 P2X purinoceptor 3 Homo sapiens 32 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183235 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183235&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578628 313634635 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331029 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n(CCC(C)(C)C(=O)OCc2ccccc2)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C32H34ClFN4O5/c1-21(2)43-27-15-14-25(18-26(27)34)35-29-36-30(40)37(31(41)38(29)19-22-10-12-24(33)13-11-22)17-16-32(3,4)28(39)42-20-23-8-6-5-7-9-23/h5-15,18,21H,16-17,19-20H2,1-4H3,(H,35,36,40) TUOYSYBZHUPNQN-UHFFFAOYSA-N 183236 US9150546, I-406::US9688643, I-406::US9718790, I-0405 P2X purinoceptor 3 Homo sapiens 30 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183236 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183236&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578501 313634636 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331030 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(CCC(C)(C)C(=O)OCc2ccccc2)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C32H34Cl2N4O5/c1-21(2)43-27-15-14-25(18-26(27)34)35-29-36-30(40)37(31(41)38(29)19-22-10-12-24(33)13-11-22)17-16-32(3,4)28(39)42-20-23-8-6-5-7-9-23/h5-15,18,21H,16-17,19-20H2,1-4H3,(H,35,36,40) OOPDFVLJBFXGIN-UHFFFAOYSA-N 183237 US9150546, I-407::US9688643, I-407::US9718790, I-0406 P2X purinoceptor 3 Homo sapiens 27 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183237 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183237&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578925 313634637 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331031 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n1Cc1ccc(C)cc1 InChI=1S/C25H29ClN4O5/c1-15(2)35-20-11-10-18(12-19(20)26)27-22-28-23(33)30(14-25(4,5)21(31)32)24(34)29(22)13-17-8-6-16(3)7-9-17/h6-12,15H,13-14H2,1-5H3,(H,31,32)(H,27,28,33) IEFCYNPWRFXORF-UHFFFAOYSA-N 183238 US9150546, I-408::US9688643, I-408::US9718790, I-0407 P2X purinoceptor 3 Homo sapiens 10 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183238 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183238&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578596 313634638 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331032 COC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(F)c2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C24H27FN4O5/c1-15(2)34-20-10-9-18(13-19(20)25)26-22-27-23(31)28(12-11-21(30)33-4)24(32)29(22)14-17-7-5-16(3)6-8-17/h5-10,13,15H,11-12,14H2,1-4H3,(H,26,27,31) PHPQOSGTOXGNRQ-UHFFFAOYSA-N 183239 US9150546, I-409::US9688643, I-409::US9718790, I-0408 P2X purinoceptor 3 Homo sapiens 12 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183239 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183239&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578582 313634639 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331033 COC(=O)Cn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(F)c2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C23H25FN4O5/c1-14(2)33-19-10-9-17(11-18(19)24)25-21-26-22(30)28(13-20(29)32-4)23(31)27(21)12-16-7-5-15(3)6-8-16/h5-11,14H,12-13H2,1-4H3,(H,25,26,30) WSLNIUFYXOOLNG-UHFFFAOYSA-N 183240 US9150546, I-410::US9688643, I-410::US9718790, I-0409 P2X purinoceptor 3 Homo sapiens 44 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183240 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183240&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578811 313634640 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331034 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n(CCC(O)=O)c(=O)n1Cc1ccc(C)cc1 InChI=1S/C23H25FN4O5/c1-14(2)33-19-9-8-17(12-18(19)24)25-21-26-22(31)27(11-10-20(29)30)23(32)28(21)13-16-6-4-15(3)5-7-16/h4-9,12,14H,10-11,13H2,1-3H3,(H,29,30)(H,25,26,31) ISLQRXSYZCSMAZ-UHFFFAOYSA-N 183241 US9150546, I-411::US9688643, I-411::US9718790, I-0410 P2X purinoceptor 3 Homo sapiens 61 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183241 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183241&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578680 313634641 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331035 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n1Cc1ccc(C)c(F)c1 InChI=1S/C25H28F2N4O5/c1-14(2)36-20-9-8-17(11-19(20)27)28-22-29-23(34)31(13-25(4,5)21(32)33)24(35)30(22)12-16-7-6-15(3)18(26)10-16/h6-11,14H,12-13H2,1-5H3,(H,32,33)(H,28,29,34) IBIXQPAHELGEQO-UHFFFAOYSA-N 183242 US9150546, I-413::US9688643, I-413::US9718790, I-0412 P2X purinoceptor 3 Homo sapiens 99 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183242 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183242&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578614 313634642 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331036 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n(CC(=O)NC(CO)CO)c(=O)n1Cc1ccc(C)cc1 InChI=1S/C25H30FN5O6/c1-15(2)37-21-9-8-18(10-20(21)26)28-23-29-24(35)31(12-22(34)27-19(13-32)14-33)25(36)30(23)11-17-6-4-16(3)5-7-17/h4-10,15,19,32-33H,11-14H2,1-3H3,(H,27,34)(H,28,29,35) UEHTZRMWTIRNBJ-UHFFFAOYSA-N 183243 US9150546, I-414::US9688643, I-414::US9718790, I-0413 P2X purinoceptor 3 Homo sapiens 7 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183243 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183243&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 70645185 313634643 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331037 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n(CC(=O)NC(C)(C)C(O)=O)c(=O)n1Cc1ccc(C)cc1 InChI=1S/C26H30FN5O6/c1-15(2)38-20-11-10-18(12-19(20)27)28-23-29-24(36)32(14-21(33)30-26(4,5)22(34)35)25(37)31(23)13-17-8-6-16(3)7-9-17/h6-12,15H,13-14H2,1-5H3,(H,30,33)(H,34,35)(H,28,29,36) NTTJRMLBZJXKKV-UHFFFAOYSA-N 183244 US9150546, I-415::US9688643, I-415::US9718790, I-0414 P2X purinoceptor 3 Homo sapiens 314 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183244 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183244&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020931 313634644 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331038 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n(CC(=O)NCC(O)=O)c(=O)n1Cc1ccc(C)cc1 InChI=1S/C24H26FN5O6/c1-14(2)36-19-9-8-17(10-18(19)25)27-22-28-23(34)30(13-20(31)26-11-21(32)33)24(35)29(22)12-16-6-4-15(3)5-7-16/h4-10,14H,11-13H2,1-3H3,(H,26,31)(H,32,33)(H,27,28,34) FEDTXBHBTVGDMW-UHFFFAOYSA-N 183245 US9150546, I-416::US9688643, I-416::US9718790, I-0415 P2X purinoceptor 3 Homo sapiens 35 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183245 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183245&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 70645146 313634645 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331039 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n(CC(=O)N[C@H](C)C(O)=O)c(=O)n1Cc1ccc(C)cc1 183246 US9150546, I-417::US9688643, I-417::US9718790, I-0416 P2X purinoceptor 3 Homo sapiens 35 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183246 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183246&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 70645187 313634646 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331040 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n(CC(=O)N[C@@H](C)C(O)=O)c(=O)n1Cc1ccc(C)cc1 183247 US9150546, I-418::US9688643, I-418::US9718790, I-0417 P2X purinoceptor 3 Homo sapiens 200 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183247 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183247&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 70645188 313634647 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331041 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n(CC(=O)NC2(CC2)C(O)=O)c(=O)n1Cc1ccc(C)cc1 InChI=1S/C26H28FN5O6/c1-15(2)38-20-9-8-18(12-19(20)27)28-23-29-24(36)32(14-21(33)30-26(10-11-26)22(34)35)25(37)31(23)13-17-6-4-16(3)5-7-17/h4-9,12,15H,10-11,13-14H2,1-3H3,(H,30,33)(H,34,35)(H,28,29,36) FYJMAFNQGXRCEC-UHFFFAOYSA-N 183248 US9150546, I-419::US9688643, I-419::US9718790, I-0418 P2X purinoceptor 3 Homo sapiens 71 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183248 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183248&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020393 313634648 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331042 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n(CCC(C)(C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C25H28ClFN4O5/c1-15(2)36-20-10-9-18(13-19(20)27)28-22-29-23(34)30(12-11-25(3,4)21(32)33)24(35)31(22)14-16-5-7-17(26)8-6-16/h5-10,13,15H,11-12,14H2,1-4H3,(H,32,33)(H,28,29,34) GXZHRQJRSCDCAT-UHFFFAOYSA-N 183249 US9150546, I-420::US9688643, I-420::US9718790, I-0419 P2X purinoceptor 3 Homo sapiens 53 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183249 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183249&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578915 313634649 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331043 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(CCC(C)(C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C25H28Cl2N4O5/c1-15(2)36-20-10-9-18(13-19(20)27)28-22-29-23(34)30(12-11-25(3,4)21(32)33)24(35)31(22)14-16-5-7-17(26)8-6-16/h5-10,13,15H,11-12,14H2,1-4H3,(H,32,33)(H,28,29,34) PIKUFVDOUKAUFW-UHFFFAOYSA-N 183250 US9150546, I-421::US9688643, I-421::US9718790, I-0420 P2X purinoceptor 3 Homo sapiens 19 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183250 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183250&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578771 313634650 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331044 CCOC(=O)C1(Cn2c(=O)[nH]\c(=N/c3ccc(OC(C)C)c(F)c3)n(Cc3ccc(Cl)cc3)c2=O)CC1 InChI=1S/C26H28ClFN4O5/c1-4-36-22(33)26(11-12-26)15-32-24(34)30-23(29-19-9-10-21(20(28)13-19)37-16(2)3)31(25(32)35)14-17-5-7-18(27)8-6-17/h5-10,13,16H,4,11-12,14-15H2,1-3H3,(H,29,30,34) RNAJCWWHBFPQGC-UHFFFAOYSA-N 183251 US9150546, I-422::US9688643, I-422::US9718790, I-0421 P2X purinoceptor 3 Homo sapiens 6 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183251 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183251&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578741 313634651 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331045 CCOC(=O)C1(Cn2c(=O)[nH]\c(=N/c3ccc(OC(C)C)c(Cl)c3)n(Cc3ccc(Cl)cc3)c2=O)CC1 InChI=1S/C26H28Cl2N4O5/c1-4-36-22(33)26(11-12-26)15-32-24(34)30-23(29-19-9-10-21(20(28)13-19)37-16(2)3)31(25(32)35)14-17-5-7-18(27)8-6-17/h5-10,13,16H,4,11-12,14-15H2,1-3H3,(H,29,30,34) OMQZQMMOKOGJNF-UHFFFAOYSA-N 183252 US9150546, I-423::US9718790, I-0422 P2X purinoceptor 3 Homo sapiens 4 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183252 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183252&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578896 313634652 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331046 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n(CC2(CC2)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C24H24ClFN4O5/c1-14(2)35-19-8-7-17(11-18(19)26)27-21-28-22(33)30(13-24(9-10-24)20(31)32)23(34)29(21)12-15-3-5-16(25)6-4-15/h3-8,11,14H,9-10,12-13H2,1-2H3,(H,31,32)(H,27,28,33) SEXDOMXDYBZSNF-UHFFFAOYSA-N 183253 US9150546, I-424::US9688643, I-424::US9718790, I-0423 P2X purinoceptor 3 Homo sapiens 49 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183253 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183253&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578524 313634653 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331047 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(CC2(CC2)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C24H24Cl2N4O5/c1-14(2)35-19-8-7-17(11-18(19)26)27-21-28-22(33)30(13-24(9-10-24)20(31)32)23(34)29(21)12-15-3-5-16(25)6-4-15/h3-8,11,14H,9-10,12-13H2,1-2H3,(H,31,32)(H,27,28,33) HBBCEZGDISQHSJ-UHFFFAOYSA-N 183254 US9150546, I-425::US9688643, I-425::US9718790, I-0424 P2X purinoceptor 3 Homo sapiens 16 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183254 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183254&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578673 313634654 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331048 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(O)c(Cl)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C22H22Cl2N4O5/c1-22(2,18(30)33-3)12-28-20(31)26-19(25-15-8-9-17(29)16(24)10-15)27(21(28)32)11-13-4-6-14(23)7-5-13/h4-10,29H,11-12H2,1-3H3,(H,25,26,31) SXOZPGVWKPWJJP-UHFFFAOYSA-N 183255 US9150546, I-426::US9688643, I-426::US9718790, I-0425 P2X purinoceptor 3 Homo sapiens 211 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183255 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183255&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578584 313634655 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331049 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc3n(C)ccc3c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H26ClN5O4/c1-25(2,21(32)35-4)15-31-23(33)28-22(27-19-9-10-20-17(13-19)11-12-29(20)3)30(24(31)34)14-16-5-7-18(26)8-6-16/h5-13H,14-15H2,1-4H3,(H,27,28,33) XYQHDOWUQZVEED-UHFFFAOYSA-N 183256 BDBM265278::US9150546, I-427::US9688643, I-427 P2X purinoceptor 3 Homo sapiens 678 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183256 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183256&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578784 313634656 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331050 CC(C)(Cn1c(=O)[nH]\c(=N/c2ccc(O)c(Cl)c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O InChI=1S/C21H20Cl2N4O5/c1-21(2,17(29)30)11-27-19(31)25-18(24-14-7-8-16(28)15(23)9-14)26(20(27)32)10-12-3-5-13(22)6-4-12/h3-9,28H,10-11H2,1-2H3,(H,29,30)(H,24,25,31) GIRJLUJEDZDUPQ-UHFFFAOYSA-N 183257 US9150546, I-429::US9688643, I-429::US9718790, I-0428 P2X purinoceptor 3 Homo sapiens 779 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183257 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183257&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578463 313634657 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331051 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H31ClN4O5/c1-16(2)36-21-12-11-20(13-17(21)3)28-23-29-24(33)31(15-26(4,5)22(32)35-6)25(34)30(23)14-18-7-9-19(27)10-8-18/h7-13,16H,14-15H2,1-6H3,(H,28,29,33) HNEFEUVSRBUTDF-UHFFFAOYSA-N 183258 US9150546, I-431::US9688643, I-431::US9718790, I-0430 P2X purinoceptor 3 Homo sapiens 4 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183258 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183258&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578498 313634658 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331052 CC(C)Oc1ccc(cc1C)\N=c1/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C25H29ClN4O5/c1-15(2)35-20-11-10-19(12-16(20)3)27-22-28-23(33)30(14-25(4,5)21(31)32)24(34)29(22)13-17-6-8-18(26)9-7-17/h6-12,15H,13-14H2,1-5H3,(H,31,32)(H,27,28,33) QAOVRPBLQVFODI-UHFFFAOYSA-N 183259 US9150546, I-432::US9688643, I-432::US9718790, I-0431 P2X purinoceptor 3 Homo sapiens 26 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183259 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183259&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578521 313634659 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331053 COc1nc(=O)n(Cc2ccc(Cl)cc2)\c(=N\c2ccc(OC(C)C)c(Cl)c2)[nH]1 InChI=1S/C20H20Cl2N4O3/c1-12(2)29-17-9-8-15(10-16(17)22)23-18-24-19(28-3)25-20(27)26(18)11-13-4-6-14(21)7-5-13/h4-10,12H,11H2,1-3H3,(H,23,24,25,27) BLXHTNIMBSZEGS-UHFFFAOYSA-N 183260 US9150546, I-433::US9688643, I-433::US9718790, I-0432 P2X purinoceptor 3 Homo sapiens 199 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183260 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183260&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 119099066 313634660 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331054 CC(C)Oc1ccc(Nc2nc(OCCO)nc(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C21H22ClFN4O4/c1-13(2)31-18-8-7-16(11-17(18)23)24-19-25-20(30-10-9-28)26-21(29)27(19)12-14-3-5-15(22)6-4-14/h3-8,11,13,28H,9-10,12H2,1-2H3,(H,24,25,26,29) PHCRNZGGIOWYGF-UHFFFAOYSA-N 183261 US9150546, II-002::US9688643, II-002::US9718790, I-0434 P2X purinoceptor 3 Homo sapiens 79 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183261 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183261&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578797 313634661 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331055 CC(C)Oc1ccc(Nc2nc(OCCCO)nc(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C22H24ClFN4O4/c1-14(2)32-19-9-8-17(12-18(19)24)25-20-26-21(31-11-3-10-29)27-22(30)28(20)13-15-4-6-16(23)7-5-15/h4-9,12,14,29H,3,10-11,13H2,1-2H3,(H,25,26,27,30) CODUWDUTHTZBMI-UHFFFAOYSA-N 183262 US9150546, II-006::US9688643, II-006::US9718790, I-0438 P2X purinoceptor 3 Homo sapiens 398 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183262 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183262&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578709 313634662 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331056 CC(C)Oc1ccc(Nc2nc(OCC(CO)CO)nc(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C23H26ClFN4O5/c1-14(2)34-20-8-7-18(9-19(20)25)26-21-27-22(33-13-16(11-30)12-31)28-23(32)29(21)10-15-3-5-17(24)6-4-15/h3-9,14,16,30-31H,10-13H2,1-2H3,(H,26,27,28,32) LYDDBGQLQCSRHN-UHFFFAOYSA-N 183263 US9150546, II-008::US9688643, II-008::US9718790, I-0440 P2X purinoceptor 3 Homo sapiens 943 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183263 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183263&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578799 313634663 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331057 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(OCC(O)=O)nc(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C21H20Cl2N4O5/c1-12(2)32-17-8-7-15(9-16(17)23)24-19-25-20(31-11-18(28)29)26-21(30)27(19)10-13-3-5-14(22)6-4-13/h3-9,12H,10-11H2,1-2H3,(H,28,29)(H,24,25,26,30) AIQQRNKMARTPQG-UHFFFAOYSA-N 183264 US9150546, II-009::US9688643, II-009::US9718790, I-0441 P2X purinoceptor 3 Homo sapiens 34 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183264 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183264&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 119099067 313634664 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331058 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(OCC(C)(C)C(O)=O)nc(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C24H26Cl2N4O5/c1-14(2)35-19-10-9-17(11-18(19)26)27-21-28-22(34-13-24(3,4)20(31)32)29-23(33)30(21)12-15-5-7-16(25)8-6-15/h5-11,14H,12-13H2,1-4H3,(H,31,32)(H,27,28,29,33) JDUIQMJXOFCZDY-UHFFFAOYSA-N 183265 US9150546, II-010::US9688643, II-010::US9718790, I-0442 P2X purinoceptor 3 Homo sapiens 349 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183265 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183265&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 119099068 313634665 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331059 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(CC(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C21H20Cl2N4O5/c1-12(2)32-17-8-7-15(9-16(17)23)24-19-25-20(30)27(11-18(28)29)21(31)26(19)10-13-3-5-14(22)6-4-13/h3-9,12H,10-11H2,1-2H3,(H,28,29)(H,24,25,30) VEMXKDNCOMOECJ-UHFFFAOYSA-N 183266 US9150546, I-434::US9688643, I-434::US9718790, I-0443 P2X purinoceptor 3 Homo sapiens 407 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183266 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183266&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578367 313634666 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331060 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(CC(=O)NCC#N)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C23H22Cl2N6O4/c1-14(2)35-19-8-7-17(11-18(19)25)28-21-29-22(33)31(13-20(32)27-10-9-26)23(34)30(21)12-15-3-5-16(24)6-4-15/h3-8,11,14H,10,12-13H2,1-2H3,(H,27,32)(H,28,29,33) YIKMIGBCKDVAHZ-UHFFFAOYSA-N 183267 US9150546, I-435::US9688643, I-435::US9718790, I-0444 P2X purinoceptor 3 Homo sapiens 6 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183267 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183267&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 88558797 313634667 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331061 CNC(=O)Cn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(Cl)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C22H23Cl2N5O4/c1-13(2)33-18-9-8-16(10-17(18)24)26-20-27-21(31)29(12-19(30)25-3)22(32)28(20)11-14-4-6-15(23)7-5-14/h4-10,13H,11-12H2,1-3H3,(H,25,30)(H,26,27,31) MECLRPZHYAVFCN-UHFFFAOYSA-N 183268 US9150546, I-436::US9688643, I-436::US9718790, I-0445 P2X purinoceptor 3 Homo sapiens 8 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183268 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183268&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020149 313634668 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331062 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(CC(=O)NCCO)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C23H25Cl2N5O5/c1-14(2)35-19-8-7-17(11-18(19)25)27-21-28-22(33)30(13-20(32)26-9-10-31)23(34)29(21)12-15-3-5-16(24)6-4-15/h3-8,11,14,31H,9-10,12-13H2,1-2H3,(H,26,32)(H,27,28,33) BIYJLHSGOGOXOH-UHFFFAOYSA-N 183269 US9150546, I-437::US9688643, I-437::US9718790, I-0446 P2X purinoceptor 3 Homo sapiens 6 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183269 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183269&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020741 313634669 C04080 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331063 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(CC(=O)NCC(N)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C23H24Cl2N6O5/c1-13(2)36-18-8-7-16(9-17(18)25)28-21-29-22(34)31(12-20(33)27-10-19(26)32)23(35)30(21)11-14-3-5-15(24)6-4-14/h3-9,13H,10-12H2,1-2H3,(H2,26,32)(H,27,33)(H,28,29,34) PYMAUQBCJZWXQE-UHFFFAOYSA-N 183270 US9150546, I-438::US9688643, I-438::US9718790, I-0447 P2X purinoceptor 3 Homo sapiens 5 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183270 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183270&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020742 313634670 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331064 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n(CCC(=O)NCC#N)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C24H24ClFN6O4/c1-15(2)36-20-8-7-18(13-19(20)26)29-22-30-23(34)31(12-9-21(33)28-11-10-27)24(35)32(22)14-16-3-5-17(25)6-4-16/h3-8,13,15H,9,11-12,14H2,1-2H3,(H,28,33)(H,29,30,34) KKWDEJBVLDOLBA-UHFFFAOYSA-N 183271 US9150546, I-439::US9688643, I-439::US9718790, I-0448 P2X purinoceptor 3 Homo sapiens 18 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183271 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183271&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578770 313634671 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331065 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n(CCC(=O)NCC(N)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C24H26ClFN6O5/c1-14(2)37-19-8-7-17(11-18(19)26)29-22-30-23(35)31(10-9-21(34)28-12-20(27)33)24(36)32(22)13-15-3-5-16(25)6-4-15/h3-8,11,14H,9-10,12-13H2,1-2H3,(H2,27,33)(H,28,34)(H,29,30,35) RGZKSIUPCLTSCH-UHFFFAOYSA-N 183272 US9150546, I-440::US9688643, I-440::US9718790, I-0449 P2X purinoceptor 3 Homo sapiens 55 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183272 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183272&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578555 313634672 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331066 CCOc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(CC(C)(C)C(=O)OC)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C24H26Cl2N4O5/c1-5-35-19-11-10-17(12-18(19)26)27-21-28-22(32)30(14-24(2,3)20(31)34-4)23(33)29(21)13-15-6-8-16(25)9-7-15/h6-12H,5,13-14H2,1-4H3,(H,27,28,32) DWLNSOSNBWRGBL-UHFFFAOYSA-N 183273 US9150546, I-441::US9688643, I-441::US9718790, I-0450 P2X purinoceptor 3 Homo sapiens 11 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183273 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183273&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578550 313634673 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331067 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(OC)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H27ClN4O5/c1-15-12-18(10-11-19(15)33-4)26-21-27-22(31)29(14-24(2,3)20(30)34-5)23(32)28(21)13-16-6-8-17(25)9-7-16/h6-12H,13-14H2,1-5H3,(H,26,27,31) XOWYLKBNXGGNSB-UHFFFAOYSA-N 183274 US9150546, I-442::US9688643, I-442::US9718790, I-0451 P2X purinoceptor 3 Homo sapiens 117 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183274 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183274&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578703 313634674 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331068 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2cccc(OC(F)F)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H23ClF2N4O5/c1-23(2,18(31)34-3)13-30-21(32)28-20(27-16-5-4-6-17(11-16)35-19(25)26)29(22(30)33)12-14-7-9-15(24)10-8-14/h4-11,19H,12-13H2,1-3H3,(H,27,28,32) HFCDVAYEMKHXOT-UHFFFAOYSA-N 183275 US9150546, I-443::US9688643, I-443::US9718790, I-0452 P2X purinoceptor 3 Homo sapiens 207 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183275 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183275&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578778 313634675 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331069 COC(=O)c1ccc(Cn2c(=O)[nH]\c(=N/c3ccc(OC(C)C)c(F)c3)n(Cc3ccc(Cl)cc3)c2=O)cc1 InChI=1S/C28H26ClFN4O5/c1-17(2)39-24-13-12-22(14-23(24)30)31-26-32-27(36)34(16-18-4-8-20(9-5-18)25(35)38-3)28(37)33(26)15-19-6-10-21(29)11-7-19/h4-14,17H,15-16H2,1-3H3,(H,31,32,36) ZHMRJAFBBUPXMN-UHFFFAOYSA-N 183276 US9150546, I-444::US9688643, I-444::US9718790, I-0453 P2X purinoceptor 3 Homo sapiens 17 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183276 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183276&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578403 313634676 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331070 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n(Cc2ccc(cc2)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C27H24ClFN4O5/c1-16(2)38-23-12-11-21(13-22(23)29)30-25-31-26(36)33(15-17-3-7-19(8-4-17)24(34)35)27(37)32(25)14-18-5-9-20(28)10-6-18/h3-13,16H,14-15H2,1-2H3,(H,34,35)(H,30,31,36) DNJOLFSVJHMOER-UHFFFAOYSA-N 183277 US9150546, I-445::US9688643, I-445::US9718790, I-0454 P2X purinoceptor 3 Homo sapiens 8 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183277 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183277&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578446 313634677 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331071 CCOc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C23H24Cl2N4O5/c1-4-34-18-10-9-16(11-17(18)25)26-20-27-21(32)29(13-23(2,3)19(30)31)22(33)28(20)12-14-5-7-15(24)8-6-14/h5-11H,4,12-13H2,1-3H3,(H,30,31)(H,26,27,32) PYUFNUBNBBFONC-UHFFFAOYSA-N 183278 US9150546, I-446::US9688643, I-446::US9718790, I-0455 P2X purinoceptor 3 Homo sapiens 20 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183278 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183278&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578767 313634678 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331072 COc1ccc(cc1C)\N=c1/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C23H25ClN4O5/c1-14-11-17(9-10-18(14)33-4)25-20-26-21(31)28(13-23(2,3)19(29)30)22(32)27(20)12-15-5-7-16(24)8-6-15/h5-11H,12-13H2,1-4H3,(H,29,30)(H,25,26,31) NWLNPCNCHXEXRK-UHFFFAOYSA-N 183279 US9150546, I-447::US9688643, I-447::US9718790, I-0456 P2X purinoceptor 3 Homo sapiens 279 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183279 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183279&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578879 313634679 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331073 CC(C)(Cn1c(=O)[nH]\c(=N/c2cccc(OC(F)F)c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O InChI=1S/C22H21ClF2N4O5/c1-22(2,17(30)31)12-29-20(32)27-19(26-15-4-3-5-16(10-15)34-18(24)25)28(21(29)33)11-13-6-8-14(23)9-7-13/h3-10,18H,11-12H2,1-2H3,(H,30,31)(H,26,27,32) OUDZDPSOGUVUGK-UHFFFAOYSA-N 183280 US9150546, I-448::US9688643, I-448::US9718790, I-0457 P2X purinoceptor 3 Homo sapiens 388 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183280 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183280&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578657 313634680 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331074 COC(=O)c1cccc(Cn2c(=O)[nH]\c(=N/c3ccc(OC(C)C)c(F)c3)n(Cc3ccc(Cl)cc3)c2=O)c1 InChI=1S/C28H26ClFN4O5/c1-17(2)39-24-12-11-22(14-23(24)30)31-26-32-27(36)34(16-19-5-4-6-20(13-19)25(35)38-3)28(37)33(26)15-18-7-9-21(29)10-8-18/h4-14,17H,15-16H2,1-3H3,(H,31,32,36) HLAKNNMHJAMFON-UHFFFAOYSA-N 183281 US9150546, I-450::US9688643, I-450::US9718790, I-0459 P2X purinoceptor 3 Homo sapiens 36 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183281 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183281&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578760 313634681 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331075 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n(Cc2cccc(c2)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C27H24ClFN4O5/c1-16(2)38-23-11-10-21(13-22(23)29)30-25-31-26(36)33(15-18-4-3-5-19(12-18)24(34)35)27(37)32(25)14-17-6-8-20(28)9-7-17/h3-13,16H,14-15H2,1-2H3,(H,34,35)(H,30,31,36) KRVHHMRULNJILW-UHFFFAOYSA-N 183282 US9150546, I-451::US9688643, I-451::US9718790, I-0460 P2X purinoceptor 3 Homo sapiens 16 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183282 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183282&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578505 313634682 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331076 COC(=O)[C@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O 183283 US9150546, I-452::US9688643, I-452::US9718790, I-0461 P2X purinoceptor 3 Homo sapiens 3 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183283 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183283&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578451 313634683 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331077 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O 183284 US9150546, I-453::US9688643, I-453::US9718790, I-0462 P2X purinoceptor 3 Homo sapiens 5 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183284 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183284&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578468 313634684 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331078 CCOC(=O)c1ccccc1Cn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C29H28ClFN4O5/c1-4-39-26(36)23-8-6-5-7-20(23)17-35-28(37)33-27(32-22-13-14-25(24(31)15-22)40-18(2)3)34(29(35)38)16-19-9-11-21(30)12-10-19/h5-15,18H,4,16-17H2,1-3H3,(H,32,33,37) OBBYQKMKICRPKD-UHFFFAOYSA-N 183285 US9150546, I-454::US9688643, I-454::US9718790, I-0463 P2X purinoceptor 3 Homo sapiens 24 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183285 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183285&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578850 313634685 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331079 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n(C[C@@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 183286 US9150546, I-455::US9688643, I-455::US9718790, I-0464 P2X purinoceptor 3 Homo sapiens 30 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183286 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183286&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578375 313634686 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331080 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 183287 US9150546, I-456::US9688643, I-456::US9718790, I-0465 P2X purinoceptor 3 Homo sapiens 8 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183287 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183287&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578933 313634687 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331081 COC(=O)[C@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(Cl)c2)n(Cc2ccc(Cl)cc2)c1=O 183288 US9150546, I-457::US9688643, I-457::US9718790, I-0466 P2X purinoceptor 3 Homo sapiens 3 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183288 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183288&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578609 313634688 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331082 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(Cl)c2)n(Cc2ccc(Cl)cc2)c1=O 183289 US9150546, I-458::US9688643, I-458::US9718790, I-0467 P2X purinoceptor 3 Homo sapiens 4 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183289 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183289&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578838 313634689 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331083 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n(Cc2ccccc2C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C27H24ClFN4O5/c1-16(2)38-23-12-11-20(13-22(23)29)30-25-31-26(36)33(15-18-5-3-4-6-21(18)24(34)35)27(37)32(25)14-17-7-9-19(28)10-8-17/h3-13,16H,14-15H2,1-2H3,(H,34,35)(H,30,31,36) DVUTVMVNMJUMHZ-UHFFFAOYSA-N 183290 US9150546, I-459::US9688643, I-459::US9718790, I-0468 P2X purinoceptor 3 Homo sapiens 39 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183290 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183290&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578785 313634690 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331084 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(C[C@@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 183291 US9150546, I-460::US9688643, I-460::US9718790, I-0469 P2X purinoceptor 3 Homo sapiens 16 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183291 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183291&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578529 313634691 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331085 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 183292 US9150546, I-461::US9688643, I-461::US9718790, I-0470 P2X purinoceptor 3 Homo sapiens 9 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183292 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183292&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578746 313634692 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331086 CCOc1ccc(cc1C)\N=c1/[nH]c(=O)n(CC(C)(C)C(=O)OC)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C25H29ClN4O5/c1-6-35-20-12-11-19(13-16(20)2)27-22-28-23(32)30(15-25(3,4)21(31)34-5)24(33)29(22)14-17-7-9-18(26)10-8-17/h7-13H,6,14-15H2,1-5H3,(H,27,28,32) JQRLNIOYJHNYAQ-UHFFFAOYSA-N 183293 US9150546, I-462::US9688643, I-462::US9718790, I-0471 P2X purinoceptor 3 Homo sapiens 4 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183293 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183293&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578456 313634693 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331087 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(C)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H27ClN4O4/c1-15-6-11-19(12-16(15)2)26-21-27-22(31)29(14-24(3,4)20(30)33-5)23(32)28(21)13-17-7-9-18(25)10-8-17/h6-12H,13-14H2,1-5H3,(H,26,27,31) LCTXMEPCVOFRSI-UHFFFAOYSA-N 183294 US9150546, I-463::US9688643, I-463::US9718790, I-0472 P2X purinoceptor 3 Homo sapiens 74 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183294 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183294&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578368 313634694 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331088 Cc1ccc(cc1C)\N=c1/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C23H25ClN4O4/c1-14-5-10-18(11-15(14)2)25-20-26-21(31)28(13-23(3,4)19(29)30)22(32)27(20)12-16-6-8-17(24)9-7-16/h5-11H,12-13H2,1-4H3,(H,29,30)(H,25,26,31) VETDRJDGGSYGGI-UHFFFAOYSA-N 183295 US9150546, I-464::US9688643, I-464::US9718790, I-0473 P2X purinoceptor 3 Homo sapiens 564 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183295 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183295&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578487 313634695 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331089 CCOc1ccc(cc1C)\N=c1/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C24H27ClN4O5/c1-5-34-19-11-10-18(12-15(19)2)26-21-27-22(32)29(14-24(3,4)20(30)31)23(33)28(21)13-16-6-8-17(25)9-7-16/h6-12H,5,13-14H2,1-4H3,(H,30,31)(H,26,27,32) UAGYKUJNNDRACK-UHFFFAOYSA-N 183296 US9150546, I-465::US9688643, I-465::US9718790, I-0474 P2X purinoceptor 3 Homo sapiens 57 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183296 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183296&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578552 313634696 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331090 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2cccc(Cl)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C22H22Cl2N4O4/c1-22(2,18(29)32-3)13-28-20(30)26-19(25-17-6-4-5-16(24)11-17)27(21(28)31)12-14-7-9-15(23)10-8-14/h4-11H,12-13H2,1-3H3,(H,25,26,30) BGADQIBSLMMIBV-UHFFFAOYSA-N 183297 US9150546, I-466::US9688643, I-466::US9718790, I-0475 P2X purinoceptor 3 Homo sapiens 37 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183297 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183297&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578386 313634697 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331091 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2cccc(OC(F)(F)F)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H22ClF3N4O5/c1-22(2,18(32)35-3)13-31-20(33)29-19(28-16-5-4-6-17(11-16)36-23(25,26)27)30(21(31)34)12-14-7-9-15(24)10-8-14/h4-11H,12-13H2,1-3H3,(H,28,29,33) SPZRXZLQIWQTDM-UHFFFAOYSA-N 183298 US9150546, I-467::US9688643, I-467::US9718790, I-0476 P2X purinoceptor 3 Homo sapiens 37 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183298 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183298&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578889 313634698 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331092 CC(C)(Cn1c(=O)[nH]\c(=N/c2cccc(Cl)c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O InChI=1S/C21H20Cl2N4O4/c1-21(2,17(28)29)12-27-19(30)25-18(24-16-5-3-4-15(23)10-16)26(20(27)31)11-13-6-8-14(22)9-7-13/h3-10H,11-12H2,1-2H3,(H,28,29)(H,24,25,30) VRQZGCHSOQRPQF-UHFFFAOYSA-N 183299 US9150546, I-468::US9688643, I-468::US9718790, I-0477 P2X purinoceptor 3 Homo sapiens 137 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183299 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183299&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578413 313634699 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331093 CC(C)(Cn1c(=O)[nH]\c(=N/c2cccc(OC(F)(F)F)c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O InChI=1S/C22H20ClF3N4O5/c1-21(2,17(31)32)12-30-19(33)28-18(27-15-4-3-5-16(10-15)35-22(24,25)26)29(20(30)34)11-13-6-8-14(23)9-7-13/h3-10H,11-12H2,1-2H3,(H,31,32)(H,27,28,33) OFBGTHRBXJQAKW-UHFFFAOYSA-N 183300 US9150546, I-469::US9688643, I-469::US9718790, I-0478 P2X purinoceptor 3 Homo sapiens 101 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183300 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183300&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578601 313634700 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331094 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc3[nH]ccc3c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H24ClN5O4/c1-24(2,20(31)34-3)14-30-22(32)28-21(27-18-8-9-19-16(12-18)10-11-26-19)29(23(30)33)13-15-4-6-17(25)7-5-15/h4-12,26H,13-14H2,1-3H3,(H,27,28,32) QUUJAAQFGPTNJB-UHFFFAOYSA-N 183301 US9150546, I-470::US9688643, I-470::US9718790, I-0479 P2X purinoceptor 3 Homo sapiens 80 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183301 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183301&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578909 313634701 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331095 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2cccc(c2)C(F)(F)F)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H22ClF3N4O4/c1-22(2,18(32)35-3)13-31-20(33)29-19(28-17-6-4-5-15(11-17)23(25,26)27)30(21(31)34)12-14-7-9-16(24)10-8-14/h4-11H,12-13H2,1-3H3,(H,28,29,33) RKIAQDSYNKVHJJ-UHFFFAOYSA-N 183302 US9150546, I-471::US9688643, I-471::US9718790, I-0480 P2X purinoceptor 3 Homo sapiens 24 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183302 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183302&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578429 313634702 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331096 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(Cl)c(Cl)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C22H21Cl3N4O4/c1-22(2,18(30)33-3)12-29-20(31)27-19(26-15-8-9-16(24)17(25)10-15)28(21(29)32)11-13-4-6-14(23)7-5-13/h4-10H,11-12H2,1-3H3,(H,26,27,31) RDLMYGPENFGHLI-UHFFFAOYSA-N 183303 US9150546, I-472::US9688643, I-472::US9718790, I-0481 P2X purinoceptor 3 Homo sapiens 47 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183303 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183303&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578666 313634703 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331097 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)nc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H28ClN5O5/c1-15(2)35-19-11-10-18(12-26-19)27-21-28-22(32)30(14-24(3,4)20(31)34-5)23(33)29(21)13-16-6-8-17(25)9-7-16/h6-12,15H,13-14H2,1-5H3,(H,27,28,32) BSTAKLZFGBHMOK-UHFFFAOYSA-N 183304 US9150546, I-473::US9688643, I-473::US9718790, I-0482 P2X purinoceptor 3 Homo sapiens 583 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183304 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183304&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578441 313634704 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331098 COC(=O)C(C)n1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O 183305 US9150546, I-474::US9688643, I-474::US9718790, I-0483 P2X purinoceptor 3 Homo sapiens 14 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183305 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183305&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578472 313634705 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331099 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n(C(C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 183306 US9150546, I-475::US9688643, I-475::US9718790, I-0484 P2X purinoceptor 3 Homo sapiens 571 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183306 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183306&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578660 313634706 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331100 CC(C)(Cn1c(=O)[nH]\c(=N/c2cccc(c2)C(F)(F)F)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O InChI=1S/C22H20ClF3N4O4/c1-21(2,17(31)32)12-30-19(33)28-18(27-16-5-3-4-14(10-16)22(24,25)26)29(20(30)34)11-13-6-8-15(23)9-7-13/h3-10H,11-12H2,1-2H3,(H,31,32)(H,27,28,33) GWKWQVXRPIJDAM-UHFFFAOYSA-N 183307 US9150546, I-476::US9688643, I-476::US9718790, I-0485 P2X purinoceptor 3 Homo sapiens 35 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183307 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183307&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578436 313634707 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331101 CC(C)(Cn1c(=O)[nH]\c(=N/c2ccc(Cl)c(Cl)c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O InChI=1S/C21H19Cl3N4O4/c1-21(2,17(29)30)11-28-19(31)26-18(25-14-7-8-15(23)16(24)9-14)27(20(28)32)10-12-3-5-13(22)6-4-12/h3-9H,10-11H2,1-2H3,(H,29,30)(H,25,26,31) VMTZHIZQTJWQIE-UHFFFAOYSA-N 183308 US9150546, I-477::US9688643, I-477::US9718790, I-0486 P2X purinoceptor 3 Homo sapiens 56 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183308 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183308&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578604 313634708 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331102 CC(C)(Cn1c(=O)[nH]\c(=N/c2ccc3[nH]ccc3c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O InChI=1S/C23H22ClN5O4/c1-23(2,19(30)31)13-29-21(32)27-20(26-17-7-8-18-15(11-17)9-10-25-18)28(22(29)33)12-14-3-5-16(24)6-4-14/h3-11,25H,12-13H2,1-2H3,(H,30,31)(H,26,27,32) CISPGXOHZZTVHA-UHFFFAOYSA-N 183309 US9150546, I-478::US9688643, I-478::US9718790, I-0487 P2X purinoceptor 3 Homo sapiens 629 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183309 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183309&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578908 313634709 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331103 COC(=O)[C@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)cc2)n(Cc2ccc(Cl)cc2)c1=O 183310 US9150546, I-479::US9688643, I-479::US9718790, I-0488 P2X purinoceptor 3 Homo sapiens 7 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183310 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183310&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578589 313634710 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331104 CCOc1ccc(cc1)\N=c1/[nH]c(=O)n(C[C@@H](C)C(=O)OC)c(=O)n1Cc1ccc(Cl)cc1 183311 US9150546, I-480::US9688643, I-480::US9718790, I-0489 P2X purinoceptor 3 Homo sapiens 12 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183311 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183311&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578937 313634711 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331105 CCOc1ccc(cc1C)\N=c1/[nH]c(=O)n(C[C@@H](C)C(=O)OC)c(=O)n1Cc1ccc(Cl)cc1 183312 US9150546, I-481::US9688643, I-481::US9718790, I-0490 P2X purinoceptor 3 Homo sapiens 12 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183312 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183312&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578417 313634712 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331106 CC(C)Oc1ccc(cc1)\N=c1/[nH]c(=O)n(C[C@@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 183313 US9150546, I-483::US9688643, I-483::US9718790, I-0492 P2X purinoceptor 3 Homo sapiens 100 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183313 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183313&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578892 313634713 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331107 CCOc1ccc(cc1)\N=c1/[nH]c(=O)n(C[C@@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 183314 US9150546, I-484::US9688643, I-484::US9718790, I-0493 P2X purinoceptor 3 Homo sapiens 290 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183314 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183314&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578830 313634714 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331108 CCOc1ccc(cc1C)\N=c1/[nH]c(=O)n(C[C@@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 183315 US9150546, I-485::US9688643, I-485::US9718790, I-0494 P2X purinoceptor 3 Homo sapiens 198 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183315 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183315&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578794 313634715 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331109 CC(C)Oc1ccc(cc1C)\N=c1/[nH]c(=O)n(C[C@@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 183316 US9150546, I-486::US9688643, I-486::US9718790, I-0495 P2X purinoceptor 3 Homo sapiens 42 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183316 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183316&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578773 313634716 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331110 CCOc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(C[C@@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 183317 US9150546, I-487::US9688643, I-487::US9718790, I-0496 P2X purinoceptor 3 Homo sapiens 27 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183317 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183317&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578939 313634717 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331111 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc3oc(C)nc3c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H24ClN5O5/c1-14-26-18-11-17(9-10-19(18)35-14)27-21-28-22(32)30(13-24(2,3)20(31)34-4)23(33)29(21)12-15-5-7-16(25)8-6-15/h5-11H,12-13H2,1-4H3,(H,27,28,32) BWWMLEAJMQPMGW-UHFFFAOYSA-N 183318 US9150546, I-488::US9688643, I-488::US9718790, I-0497 P2X purinoceptor 3 Homo sapiens 124 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183318 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183318&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578565 313634718 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331112 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc3oc(C)cc3c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H25ClN4O5/c1-15-11-17-12-19(9-10-20(17)35-15)27-22-28-23(32)30(14-25(2,3)21(31)34-4)24(33)29(22)13-16-5-7-18(26)8-6-16/h5-12H,13-14H2,1-4H3,(H,27,28,32) GYFNLPAGZFKNSP-UHFFFAOYSA-N 183319 US9150546, I-489::US9688643, I-489::US9718790, I-0498 P2X purinoceptor 3 Homo sapiens 10 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183319 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183319&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578659 313634719 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331113 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(CN(C)C)c(Cl)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H29Cl2N5O4/c1-25(2,21(33)36-5)15-32-23(34)29-22(28-19-11-8-17(14-30(3)4)20(27)12-19)31(24(32)35)13-16-6-9-18(26)10-7-16/h6-12H,13-15H2,1-5H3,(H,28,29,34) XHHFQYQVSXWJKI-UHFFFAOYSA-N 183320 US9150546, I-490::US9688643, I-490::US9718790, I-0499 P2X purinoceptor 3 Homo sapiens 46 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183320 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183320&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578600 313634720 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331114 Cc1cc2cc(ccc2o1)\N=c1/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C24H23ClN4O5/c1-14-10-16-11-18(8-9-19(16)34-14)26-21-27-22(32)29(13-24(2,3)20(30)31)23(33)28(21)12-15-4-6-17(25)7-5-15/h4-11H,12-13H2,1-3H3,(H,30,31)(H,26,27,32) BDZSWGJDARTUHN-UHFFFAOYSA-N 183321 US9150546, I-491::US9688643, I-491::US9718790, I-0500 P2X purinoceptor 3 Homo sapiens 27 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183321 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183321&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578954 313634721 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331115 CCn1ccc2cc(ccc12)\N=c1/[nH]c(=O)n(CC(C)(C)C(=O)OC)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C26H28ClN5O4/c1-5-30-13-12-18-14-20(10-11-21(18)30)28-23-29-24(34)32(16-26(2,3)22(33)36-4)25(35)31(23)15-17-6-8-19(27)9-7-17/h6-14H,5,15-16H2,1-4H3,(H,28,29,34) YGKBHZHTBZHKRV-UHFFFAOYSA-N 183322 US9150546, I-492::US9688643, I-492::US9718790, I-0501 P2X purinoceptor 3 Homo sapiens 102 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183322 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183322&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578940 313634722 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331116 CCn1ccc2cc(ccc12)\N=c1/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C25H26ClN5O4/c1-4-29-12-11-17-13-19(9-10-20(17)29)27-22-28-23(34)31(15-25(2,3)21(32)33)24(35)30(22)14-16-5-7-18(26)8-6-16/h5-13H,4,14-15H2,1-3H3,(H,32,33)(H,27,28,34) JOBNQHGVFFAIKQ-UHFFFAOYSA-N 183323 US9150546, I-493::US9688643, I-493::US9718790, I-0502 P2X purinoceptor 3 Homo sapiens 952 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183323 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183323&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578622 313634723 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331117 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc3nc(C)oc3c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H24ClN5O5/c1-14-26-18-10-9-17(11-19(18)35-14)27-21-28-22(32)30(13-24(2,3)20(31)34-4)23(33)29(21)12-15-5-7-16(25)8-6-15/h5-11H,12-13H2,1-4H3,(H,27,28,32) DERUTLWVSXYUBL-UHFFFAOYSA-N 183324 US9150546, I-494::US9688643, I-494::US9718790, I-0503 P2X purinoceptor 3 Homo sapiens 34 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183324 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183324&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578858 313634724 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331118 CN(C)Cc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C24H27Cl2N5O4/c1-24(2,20(32)33)14-31-22(34)28-21(27-18-10-7-16(13-29(3)4)19(26)11-18)30(23(31)35)12-15-5-8-17(25)9-6-15/h5-11H,12-14H2,1-4H3,(H,32,33)(H,27,28,34) CQRVXUVYPUKGAY-UHFFFAOYSA-N 183325 US9150546, I-495::US9688643, I-495::US9718790, I-0504 P2X purinoceptor 3 Homo sapiens 125 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183325 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183325&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578874 313634725 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331119 Cc1nc2ccc(cc2o1)\N=c1/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C23H22ClN5O5/c1-13-25-17-9-8-16(10-18(17)34-13)26-20-27-21(32)29(12-23(2,3)19(30)31)22(33)28(20)11-14-4-6-15(24)7-5-14/h4-10H,11-12H2,1-3H3,(H,30,31)(H,26,27,32) MDIBYOPAIJSTAN-UHFFFAOYSA-N 183326 US9150546, I-496::US9688643, I-496::US9718790, I-0505 P2X purinoceptor 3 Homo sapiens 125 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183326 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183326&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578848 313634726 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331120 Cc1nc2cc(ccc2o1)\N=c1/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C23H22ClN5O5/c1-13-25-17-10-16(8-9-18(17)34-13)26-20-27-21(32)29(12-23(2,3)19(30)31)22(33)28(20)11-14-4-6-15(24)7-5-14/h4-10H,11-12H2,1-3H3,(H,30,31)(H,26,27,32) QXSSRYCKGNMWJG-UHFFFAOYSA-N 183327 US9150546, I-497::US9688643, I-497::US9718790, I-0506 P2X purinoceptor 3 Homo sapiens 458 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183327 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183327&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578615 313634727 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331121 CCOC(=O)CCCn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(Cl)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H28Cl2N4O5/c1-4-35-22(32)6-5-13-30-24(33)29-23(28-19-11-12-21(20(27)14-19)36-16(2)3)31(25(30)34)15-17-7-9-18(26)10-8-17/h7-12,14,16H,4-6,13,15H2,1-3H3,(H,28,29,33) RZCZZXLNXHRKPV-UHFFFAOYSA-N 183328 US9150546, I-498::US9688643, I-498::US9718790, I-0507 P2X purinoceptor 3 Homo sapiens 9 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183328 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183328&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578625 313634728 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331122 CC(C)Oc1ccc(cc1C)\N=c1/[nH]c(=O)[nH]c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C20H21ClN4O3/c1-12(2)28-17-9-8-16(10-13(17)3)22-18-23-19(26)24-20(27)25(18)11-14-4-6-15(21)7-5-14/h4-10,12H,11H2,1-3H3,(H2,22,23,24,26,27) BISBPWAYYOPSQX-UHFFFAOYSA-N 183329 US9150546, I-499::US9688643, I-499::US9718790, I-0508 P2X purinoceptor 3 Homo sapiens 137 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183329 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183329&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578699 313634729 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331123 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(CCCC(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C23H24Cl2N4O5/c1-14(2)34-19-10-9-17(12-18(19)25)26-21-27-22(32)28(11-3-4-20(30)31)23(33)29(21)13-15-5-7-16(24)8-6-15/h5-10,12,14H,3-4,11,13H2,1-2H3,(H,30,31)(H,26,27,32) WCZMIXQUMLQDCK-UHFFFAOYSA-N 183330 US9150546, I-500::US9688643, I-500::US9718790, I-0509 P2X purinoceptor 3 Homo sapiens 13 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183330 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183330&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578791 313634730 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331124 Cc1cc2cc(ccc2o1)\N=c1/[nH]c(=O)[nH]c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C19H15ClN4O3/c1-11-8-13-9-15(6-7-16(13)27-11)21-17-22-18(25)23-19(26)24(17)10-12-2-4-14(20)5-3-12/h2-9H,10H2,1H3,(H2,21,22,23,25,26) LINZAOUDZMSNFJ-UHFFFAOYSA-N 183331 US9150546, I-501::US9688643, I-501::US9718790, I-0510 P2X purinoceptor 3 Homo sapiens 191 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183331 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183331&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578605 313634731 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331125 CCOC(=O)CCCn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H31ClN4O5/c1-5-35-23(32)7-6-14-30-25(33)29-24(28-21-12-13-22(18(4)15-21)36-17(2)3)31(26(30)34)16-19-8-10-20(27)11-9-19/h8-13,15,17H,5-7,14,16H2,1-4H3,(H,28,29,33) CHEHAKBBCUEQJD-UHFFFAOYSA-N 183332 US9150546, I-502::US9688643, I-502::US9718790, I-0511 P2X purinoceptor 3 Homo sapiens 20 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183332 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183332&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578821 313634732 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331126 CC(C)Oc1ccc(cc1C)\N=c1/[nH]c(=O)n(CCCC(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C24H27ClN4O5/c1-15(2)34-20-11-10-19(13-16(20)3)26-22-27-23(32)28(12-4-5-21(30)31)24(33)29(22)14-17-6-8-18(25)9-7-17/h6-11,13,15H,4-5,12,14H2,1-3H3,(H,30,31)(H,26,27,32) BXLWUDHFHPTRAG-UHFFFAOYSA-N 183333 US9150546, I-503::US9688643, I-503::US9718790, I-0512 P2X purinoceptor 3 Homo sapiens 50 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183333 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183333&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578619 313634733 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331127 CCOC(=O)CCCn1c(=O)[nH]\c(=N/c2ccc3oc(C)cc3c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H25ClN4O5/c1-3-34-22(31)5-4-12-29-24(32)28-23(27-20-10-11-21-18(14-20)13-16(2)35-21)30(25(29)33)15-17-6-8-19(26)9-7-17/h6-11,13-14H,3-5,12,15H2,1-2H3,(H,27,28,32) NRMCIFMJBUNITC-UHFFFAOYSA-N 183334 US9150546, I-504::US9688643, I-504::US9718790, I-0513 P2X purinoceptor 3 Homo sapiens 15 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183334 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183334&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578890 313634734 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331128 Cc1cc2cc(ccc2o1)\N=c1/[nH]c(=O)n(CCCC(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C23H21ClN4O5/c1-14-11-16-12-18(8-9-19(16)33-14)25-21-26-22(31)27(10-2-3-20(29)30)23(32)28(21)13-15-4-6-17(24)7-5-15/h4-9,11-12H,2-3,10,13H2,1H3,(H,29,30)(H,25,26,31) SPZUYZIZNIODLC-UHFFFAOYSA-N 183335 US9150546, I-505::US9688643, I-505::US9718790, I-0514 P2X purinoceptor 3 Homo sapiens 120 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183335 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183335&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578831 313634735 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331129 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc3n(CC(C)C)ccc3c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C28H32ClN5O4/c1-18(2)15-32-13-12-20-14-22(10-11-23(20)32)30-25-31-26(36)34(17-28(3,4)24(35)38-5)27(37)33(25)16-19-6-8-21(29)9-7-19/h6-14,18H,15-17H2,1-5H3,(H,30,31,36) YVYTXXAKCRMLAS-UHFFFAOYSA-N 183336 US9150546, I-506::US9688643, I-506::US9718790, I-0515 P2X purinoceptor 3 Homo sapiens 279 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183336 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183336&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578514 313634736 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331130 CCCn1ccc2cc(ccc12)\N=c1/[nH]c(=O)n(CC(C)(C)C(=O)OC)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C27H30ClN5O4/c1-5-13-31-14-12-19-15-21(10-11-22(19)31)29-24-30-25(35)33(17-27(2,3)23(34)37-4)26(36)32(24)16-18-6-8-20(28)9-7-18/h6-12,14-15H,5,13,16-17H2,1-4H3,(H,29,30,35) CZJPRYZTVINBPE-UHFFFAOYSA-N 183337 US9150546, I-507::US9688643, I-507::US9718790, I-0516 P2X purinoceptor 3 Homo sapiens 301 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183337 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183337&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578496 313634737 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331131 CC(C)Cn1ccc2cc(ccc12)\N=c1/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C27H30ClN5O4/c1-17(2)14-31-12-11-19-13-21(9-10-22(19)31)29-24-30-25(36)33(16-27(3,4)23(34)35)26(37)32(24)15-18-5-7-20(28)8-6-18/h5-13,17H,14-16H2,1-4H3,(H,34,35)(H,29,30,36) LSTHKOYNWJFZGC-UHFFFAOYSA-N 183338 US9150546, I-508::US9688643, I-508::US9718790, I-0517 P2X purinoceptor 3 Homo sapiens 511 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183338 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183338&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578383 313634738 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331132 CCCn1ccc2cc(ccc12)\N=c1/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C26H28ClN5O4/c1-4-12-30-13-11-18-14-20(9-10-21(18)30)28-23-29-24(35)32(16-26(2,3)22(33)34)25(36)31(23)15-17-5-7-19(27)8-6-17/h5-11,13-14H,4,12,15-16H2,1-3H3,(H,33,34)(H,28,29,35) OWGZMAZZYUSLCJ-UHFFFAOYSA-N 183339 US9150546, I-509::US9688643, I-509::US9718790, I-0518 P2X purinoceptor 3 Homo sapiens 652 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183339 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183339&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578485 313634739 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331133 CSc1cccc(c1)\N=c1/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C22H23ClN4O4S/c1-22(2,18(28)29)13-27-20(30)25-19(24-16-5-4-6-17(11-16)32-3)26(21(27)31)12-14-7-9-15(23)10-8-14/h4-11H,12-13H2,1-3H3,(H,28,29)(H,24,25,30) DQUCQFHPLJOMDY-UHFFFAOYSA-N 183340 US9150546, I-510::US9688643, I-510::US9718790, I-0519 P2X purinoceptor 3 Homo sapiens 98 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183340 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183340&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578919 313634740 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331134 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(F)c2)n(Cc2ccc(C)cc2)c1=O 183341 US9150546, I-515::US9688643, I-515::US9718790, I-0524 P2X purinoceptor 3 Homo sapiens 6 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183341 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183341&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578641 313634741 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331135 CCOC(=O)CCCn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(Cl)c2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C26H31ClN4O5/c1-5-35-23(32)7-6-14-30-25(33)29-24(28-20-12-13-22(21(27)15-20)36-17(2)3)31(26(30)34)16-19-10-8-18(4)9-11-19/h8-13,15,17H,5-7,14,16H2,1-4H3,(H,28,29,33) SGZWRROGODEEEX-UHFFFAOYSA-N 183342 US9150546, I-516::US9688643, I-516::US9718790, I-0525 P2X purinoceptor 3 Homo sapiens 5 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183342 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183342&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578724 313634742 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331136 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(C)cc1 183343 US9150546, I-517::US9688643, I-517::US9718790, I-0526 P2X purinoceptor 3 Homo sapiens 15 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183343 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183343&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578710 313634743 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331137 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(C)cc1 183344 US9150546, I-518::US9688643, I-518::US9718790, I-0527 P2X purinoceptor 3 Homo sapiens 7 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183344 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183344&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578621 313634744 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331138 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(CCCC(O)=O)c(=O)n1Cc1ccc(C)cc1 InChI=1S/C24H27ClN4O5/c1-15(2)34-20-11-10-18(13-19(20)25)26-22-27-23(32)28(12-4-5-21(30)31)24(33)29(22)14-17-8-6-16(3)7-9-17/h6-11,13,15H,4-5,12,14H2,1-3H3,(H,30,31)(H,26,27,32) NXLSNMXBBXKVGK-UHFFFAOYSA-N 183345 US9150546, I-519::US9688643, I-519::US9718790, I-0528 P2X purinoceptor 3 Homo sapiens 12 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183345 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183345&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578649 313634745 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331139 Cc1cc2cc(ccc2o1)\N=c1/[nH]c(=O)n(CCCC(O)=O)c(=O)n1Cc1ccc(C)cc1 InChI=1S/C24H24N4O5/c1-15-5-7-17(8-6-15)14-28-22(25-19-9-10-20-18(13-19)12-16(2)33-20)26-23(31)27(24(28)32)11-3-4-21(29)30/h5-10,12-13H,3-4,11,14H2,1-2H3,(H,29,30)(H,25,26,31) MQVCATJXUIBEEK-UHFFFAOYSA-N 183346 US9150546, I-520::US9688643, I-520::US9718790, I-0529 P2X purinoceptor 3 Homo sapiens 80 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183346 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183346&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578423 313634746 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331140 CCOC(=O)CCCn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(C)c2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C27H34N4O5/c1-6-35-24(32)8-7-15-30-26(33)29-25(28-22-13-14-23(20(5)16-22)36-18(2)3)31(27(30)34)17-21-11-9-19(4)10-12-21/h9-14,16,18H,6-8,15,17H2,1-5H3,(H,28,29,33) CBVQUWBWGAGXAO-UHFFFAOYSA-N 183347 US9150546, I-521::US9688643, I-521::US9718790, I-0530 P2X purinoceptor 3 Homo sapiens 4 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183347 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183347&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578914 313634747 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331141 COC(=O)C[C@H](C)n1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(Cl)c2)n(Cc2ccc(Cl)cc2)c1=O 183348 US9150546, I-522::US9688643, I-522::US9718790, I-0531 P2X purinoceptor 3 Homo sapiens 29 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183348 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183348&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578461 313634748 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331142 COC(=O)C[C@H](C)n1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O 183349 US9150546, I-523::US9688643, I-523::US9718790, I-0532 P2X purinoceptor 3 Homo sapiens 72 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183349 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183349&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578435 313634749 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331143 COC(=O)C[C@H](C)n1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O 183350 US9150546, I-524::US9688643, I-524::US9718790, I-0533 P2X purinoceptor 3 Homo sapiens 60 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183350 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183350&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578592 313634750 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331144 CC(C)Oc1ccc(cc1C)\N=c1/[nH]c(=O)n(CCCC(O)=O)c(=O)n1Cc1ccc(C)cc1 InChI=1S/C25H30N4O5/c1-16(2)34-21-12-11-20(14-18(21)4)26-23-27-24(32)28(13-5-6-22(30)31)25(33)29(23)15-19-9-7-17(3)8-10-19/h7-12,14,16H,5-6,13,15H2,1-4H3,(H,30,31)(H,26,27,32) PTNDSIGCKJDYDW-UHFFFAOYSA-N 183351 US9150546, I-525::US9688643, I-525::US9718790, I-0534 P2X purinoceptor 3 Homo sapiens 54 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183351 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183351&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578449 313634751 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331145 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n([C@@H](C)CC(O)=O)c(=O)n1Cc1ccc(Cl)cc1 183352 US9150546, I-526::US9688643, I-526::US9718790, I-0535 P2X purinoceptor 3 Homo sapiens 24 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183352 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183352&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578743 313634752 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331146 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n([C@@H](C)CC(O)=O)c(=O)n1Cc1ccc(Cl)cc1 183353 US9150546, I-527::US9688643, I-527::US9718790, I-0536 P2X purinoceptor 3 Homo sapiens 33 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183353 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183353&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578893 313634753 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331147 CC(C)Oc1ccc(cc1C)\N=c1/[nH]c(=O)n([C@@H](C)CC(O)=O)c(=O)n1Cc1ccc(Cl)cc1 183354 US9150546, I-528::US9688643, I-528::US9718790, I-0537 P2X purinoceptor 3 Homo sapiens 53 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183354 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183354&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578907 313634754 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331148 COC(=O)[C@@H](C)Cn1c(=O)nc(Nc2ccc(OC(C)C)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H27ClN4O5/c1-15(2)34-20-11-9-19(10-12-20)26-22-27-23(31)29(13-16(3)21(30)33-4)24(32)28(22)14-17-5-7-18(25)8-6-17/h5-12,15-16H,13-14H2,1-4H3,(H,26,27,31)/t16-/m0/s1 PNDUVKCLDPNYPJ-INIZCTEOSA-N 183355 US9150546, I-529::US9688643, I-529::US9718790, I-0538 P2X purinoceptor 3 Homo sapiens 22 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183355 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183355&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117900854 313634755 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331149 CCOc1ccc(Nc2nc(=O)n(C[C@H](C)C(=O)OC)c(=O)n2Cc2ccc(Cl)cc2)cc1 InChI=1S/C23H25ClN4O5/c1-4-33-19-11-9-18(10-12-19)25-21-26-22(30)28(13-15(2)20(29)32-3)23(31)27(21)14-16-5-7-17(24)8-6-16/h5-12,15H,4,13-14H2,1-3H3,(H,25,26,30)/t15-/m0/s1 LLXZMQNNOVIISR-HNNXBMFYSA-N 183356 US9150546, I-530::US9688643, I-530::US9718790, I-0539 P2X purinoceptor 3 Homo sapiens 34 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183356 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183356&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 119099069 313634756 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331150 COC(=O)[C@@H](C)Cn1c(=O)nc(Nc2ccc(OC(C)C)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H29ClN4O5/c1-15(2)35-21-11-10-20(12-16(21)3)27-23-28-24(32)30(13-17(4)22(31)34-5)25(33)29(23)14-18-6-8-19(26)9-7-18/h6-12,15,17H,13-14H2,1-5H3,(H,27,28,32)/t17-/m0/s1 GVMFNMJAZZEXOQ-KRWDZBQOSA-N 183357 US9150546, I-531::US9688643, I-531::US9718790, I-0540 P2X purinoceptor 3 Homo sapiens 10 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183357 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183357&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 119099070 313634757 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331151 CCOc1ccc(Nc2nc(=O)n(C[C@H](C)C(=O)OC)c(=O)n2Cc2ccc(Cl)cc2)cc1C InChI=1S/C24H27ClN4O5/c1-5-34-20-11-10-19(12-15(20)2)26-22-27-23(31)29(13-16(3)21(30)33-4)24(32)28(22)14-17-6-8-18(25)9-7-17/h6-12,16H,5,13-14H2,1-4H3,(H,26,27,31)/t16-/m0/s1 AHRHHAOVZLVQPW-INIZCTEOSA-N 183358 US9150546, I-532::US9688643, I-532::US9718790, I-0541 P2X purinoceptor 3 Homo sapiens 29 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183358 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183358&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 119099071 313634758 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331152 CCOc1ccc(Nc2nc(=O)n(C[C@H](C)C(=O)OC)c(=O)n2Cc2ccc(Cl)cc2)cc1Cl InChI=1S/C23H24Cl2N4O5/c1-4-34-19-10-9-17(11-18(19)25)26-21-27-22(31)29(12-14(2)20(30)33-3)23(32)28(21)13-15-5-7-16(24)8-6-15/h5-11,14H,4,12-13H2,1-3H3,(H,26,27,31)/t14-/m0/s1 YDMQMBMMHSDJFG-AWEZNQCLSA-N 183359 US9150546, I-533::US9688643, I-533::US9718790, I-0542 P2X purinoceptor 3 Homo sapiens 10 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183359 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183359&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 119099072 313634759 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331153 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc3oc(C)cc3c2)n(Cc2ccc(Cl)cc2)c1=O 183360 US9150546, I-534::US9688643, I-534::US9718790, I-0543 P2X purinoceptor 3 Homo sapiens 18 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183360 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183360&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578525 313634760 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331154 CCOc1ccc(cc1)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 183361 US9150546, I-535::US9688643, I-535::US9718790, I-0544 P2X purinoceptor 3 Homo sapiens 52 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183361 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183361&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578651 313634761 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331155 CCOc1ccc(cc1C)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 183362 US9150546, I-536::US9688643, I-536::US9718790, I-0545 P2X purinoceptor 3 Homo sapiens 46 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183362 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183362&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578788 313634762 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331156 CC(C)Oc1ccc(cc1)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 183363 US9150546, I-537::US9688643, I-537::US9718790, I-0546 P2X purinoceptor 3 Homo sapiens 19 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183363 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183363&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578598 313634763 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331157 CC(C)Oc1ccc(cc1C)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 183364 US9150546, I-538::US9688643, I-538::US9718790, I-0547 P2X purinoceptor 3 Homo sapiens 16 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183364 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183364&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578644 313634764 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331158 CCOc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 183365 US9150546, I-539::US9688643, I-539::US9718790, I-0548 P2X purinoceptor 3 Homo sapiens 7 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183365 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183365&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578535 313634765 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331159 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc3oc(C)cc3c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 183366 US9150546, I-540::US9688643, I-540::US9718790, I-0549 P2X purinoceptor 3 Homo sapiens 27 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183366 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183366&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578454 313634766 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331160 CC(C)Oc1ccc(cc1)\N=c1/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C24H27ClN4O5/c1-15(2)34-19-11-9-18(10-12-19)26-21-27-22(32)29(14-24(3,4)20(30)31)23(33)28(21)13-16-5-7-17(25)8-6-16/h5-12,15H,13-14H2,1-4H3,(H,30,31)(H,26,27,32) JCPCQJZKKYRYKO-UHFFFAOYSA-N 183367 US9150546, I-541::US9688643, I-541::US9718790, I-0550 P2X purinoceptor 3 Homo sapiens 58 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183367 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183367&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578444 313634767 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331161 CCOc1ccc(cc1)\N=c1/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C23H25ClN4O5/c1-4-33-18-11-9-17(10-12-18)25-20-26-21(31)28(14-23(2,3)19(29)30)22(32)27(20)13-15-5-7-16(24)8-6-15/h5-12H,4,13-14H2,1-3H3,(H,29,30)(H,25,26,31) XUZSADSANSSCJR-UHFFFAOYSA-N 183368 US9150546, I-542::US9688643, I-542::US9718790, I-0551 P2X purinoceptor 3 Homo sapiens 96 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183368 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183368&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578394 313634768 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331162 CC(C)(Cn1c(=O)[nH]\c(=N/c2ccc(OC(F)F)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O InChI=1S/C22H21ClF2N4O5/c1-22(2,17(30)31)12-29-20(32)27-19(26-15-7-9-16(10-8-15)34-18(24)25)28(21(29)33)11-13-3-5-14(23)6-4-13/h3-10,18H,11-12H2,1-2H3,(H,30,31)(H,26,27,32) GYEVZEZSHHFIPQ-UHFFFAOYSA-N 183369 US9150546, I-543::US9688643, I-543::US9718790, I-0552 P2X purinoceptor 3 Homo sapiens 172 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183369 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183369&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578802 313634769 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331163 CSc1ccc(cc1)\N=c1/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C22H23ClN4O4S/c1-22(2,18(28)29)13-27-20(30)25-19(24-16-8-10-17(32-3)11-9-16)26(21(27)31)12-14-4-6-15(23)7-5-14/h4-11H,12-13H2,1-3H3,(H,28,29)(H,24,25,30) CZLXUMOXYGNOSM-UHFFFAOYSA-N 183370 US9150546, I-544::US9688643, I-544::US9718790, I-0553 P2X purinoceptor 3 Homo sapiens 601 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183370 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183370&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578952 313634770 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331164 CC(C)Oc1ccc(Nc2nc(=O)n(CCOC3CCCCO3)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C26H30ClFN4O5/c1-17(2)37-22-11-10-20(15-21(22)28)29-24-30-25(33)31(12-14-36-23-5-3-4-13-35-23)26(34)32(24)16-18-6-8-19(27)9-7-18/h6-11,15,17,23H,3-5,12-14,16H2,1-2H3,(H,29,30,33) RKURIGKRJVTWEA-UHFFFAOYSA-N 183371 US9150546, I-545::US9688643, I-545::US9718790, I-0554 P2X purinoceptor 3 Homo sapiens 6 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183371 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183371&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76820961 313634771 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331165 CC(C)Oc1ccc(cc1F)\N=c1/n(C)c(=O)n(CCOC2CCCCO2)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C27H32ClFN4O5/c1-18(2)38-23-12-11-21(16-22(23)29)30-25-31(3)26(34)32(13-15-37-24-6-4-5-14-36-24)27(35)33(25)17-19-7-9-20(28)10-8-19/h7-12,16,18,24H,4-6,13-15,17H2,1-3H3/b30-25+ NYQXKNHJLZHVCJ-QCWLDUFUSA-N 183372 US9150546, I-546::US9688643, I-546::US9718790, I-0555 P2X purinoceptor 3 Homo sapiens 459 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183372 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183372&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578748 313634772 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331166 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(Cl)c2)n(CC2CCCCC2)c1=O InChI=1S/C25H35ClN4O5/c1-16(2)35-20-12-11-18(13-19(20)26)27-22-28-23(32)30(15-25(3,4)21(31)34-5)24(33)29(22)14-17-9-7-6-8-10-17/h11-13,16-17H,6-10,14-15H2,1-5H3,(H,27,28,32) DEKOKCCTTJDCJS-UHFFFAOYSA-N 183373 US9150546, I-547::US9688643, I-547::US9718790, I-0556 P2X purinoceptor 3 Homo sapiens 11 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183373 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183373&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578842 313634773 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331167 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(Cl)c2)n(CC2CCCCC2)c1=O 183374 US9150546, I-548::US9688643, I-548::US9718790, I-0557 P2X purinoceptor 3 Homo sapiens 12 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183374 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183374&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578956 313634774 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331168 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(Cl)c2)n(CC2CCCCCC2)c1=O InChI=1S/C26H37ClN4O5/c1-17(2)36-21-13-12-19(14-20(21)27)28-23-29-24(33)31(16-26(3,4)22(32)35-5)25(34)30(23)15-18-10-8-6-7-9-11-18/h12-14,17-18H,6-11,15-16H2,1-5H3,(H,28,29,33) NEKLZKIZXQWIFI-UHFFFAOYSA-N 183375 US9150546, I-549::US9688643, I-549::US9718790, I-0558 P2X purinoceptor 3 Homo sapiens 19 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183375 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183375&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578662 313634775 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331169 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(Cl)c2)n(CC2CCCC2)c1=O InChI=1S/C24H33ClN4O5/c1-15(2)34-19-11-10-17(12-18(19)25)26-21-27-22(31)29(14-24(3,4)20(30)33-5)23(32)28(21)13-16-8-6-7-9-16/h10-12,15-16H,6-9,13-14H2,1-5H3,(H,26,27,31) HESZPANWMDSMDF-UHFFFAOYSA-N 183376 US9150546, I-550::US9688643, I-550::US9718790, I-0559 P2X purinoceptor 3 Homo sapiens 33 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183376 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183376&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578533 313634776 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331170 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n1CC1CCCCC1 InChI=1S/C24H33ClN4O5/c1-15(2)34-19-11-10-17(12-18(19)25)26-21-27-22(32)29(14-24(3,4)20(30)31)23(33)28(21)13-16-8-6-5-7-9-16/h10-12,15-16H,5-9,13-14H2,1-4H3,(H,30,31)(H,26,27,32) NMNCTROXPGYIOQ-UHFFFAOYSA-N 183377 US9150546, I-551::US9688643, I-551::US9718790, I-0560 P2X purinoceptor 3 Homo sapiens 34 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183377 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183377&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578406 313634777 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331171 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1CC1CCCCC1 183378 US9150546, I-552::US9688643, I-552::US9718790, I-0561 P2X purinoceptor 3 Homo sapiens 23 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183378 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183378&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578395 313634778 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331172 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n1CC1CCCCCC1 InChI=1S/C25H35ClN4O5/c1-16(2)35-20-12-11-18(13-19(20)26)27-22-28-23(33)30(15-25(3,4)21(31)32)24(34)29(22)14-17-9-7-5-6-8-10-17/h11-13,16-17H,5-10,14-15H2,1-4H3,(H,31,32)(H,27,28,33) ZVPWBFOPYYQMCZ-UHFFFAOYSA-N 183379 US9150546, I-553::US9688643, I-553::US9718790, I-0562 P2X purinoceptor 3 Homo sapiens 34 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183379 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183379&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578707 313634779 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331173 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n1CC1CCCC1 InChI=1S/C23H31ClN4O5/c1-14(2)33-18-10-9-16(11-17(18)24)25-20-26-21(31)28(13-23(3,4)19(29)30)22(32)27(20)12-15-7-5-6-8-15/h9-11,14-15H,5-8,12-13H2,1-4H3,(H,29,30)(H,25,26,31) KHYUIQKXCLVOAV-UHFFFAOYSA-N 183380 US9150546, I-554::US9688643, I-554::US9718790, I-0563 P2X purinoceptor 3 Homo sapiens 139 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183380 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183380&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578656 313634780 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331174 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(C)c2)n(CC2CCCCC2)c1=O 183381 US9150546, I-555::US9688643, I-555::US9718790, I-0564 P2X purinoceptor 3 Homo sapiens 13 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183381 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183381&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578401 313634781 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331175 COC(=O)C[C@@H](C)n1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(Cl)c2)n(Cc2ccc(Cl)cc2)c1=O 183382 US9150546, I-556::US9688643, I-556::US9718790, I-0565 P2X purinoceptor 3 Homo sapiens 5 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183382 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183382&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578716 313634782 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331176 COC(=O)C[C@@H](C)n1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O 183383 US9150546, I-557::US9688643, I-557::US9718790, I-0566 P2X purinoceptor 3 Homo sapiens 19 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183383 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183383&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578452 313634783 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331177 COC(=O)[C@H](C)Cn1c(=O)[nH]\c(=N/c2ccc3oc(C)cc3c2)n(Cc2ccc(Cl)cc2)c1=O 183384 US9150546, I-558::US9688643, I-558::US9718790, I-0567 P2X purinoceptor 3 Homo sapiens 5 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183384 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183384&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578519 313634784 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331178 CC(C)Oc1ccc(cc1C)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1CC1CCCCC1 183385 US9150546, I-559::US9688643, I-559::US9718790, I-0568 P2X purinoceptor 3 Homo sapiens 97 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183385 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183385&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578595 313634785 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331179 COC(=O)C[C@@H](C)n1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O 183386 US9150546, I-560::US9688643, I-560::US9718790, I-0569 P2X purinoceptor 3 Homo sapiens 7 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183386 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183386&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578772 313634786 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331180 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n([C@H](C)CC(O)=O)c(=O)n1Cc1ccc(Cl)cc1 183387 US9150546, I-561::US9688643, I-561::US9718790, I-0570 P2X purinoceptor 3 Homo sapiens 8 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183387 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183387&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578547 313634787 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331181 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n([C@H](C)CC(O)=O)c(=O)n1Cc1ccc(Cl)cc1 183388 US9150546, I-562::US9688643, I-562::US9718790, I-0571 P2X purinoceptor 3 Homo sapiens 27 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183388 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183388&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578745 313634788 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331182 CC(C)Oc1ccc(cc1C)\N=c1/[nH]c(=O)n([C@H](C)CC(O)=O)c(=O)n1Cc1ccc(Cl)cc1 183389 US9150546, I-563::US9688643, I-563::US9718790, I-0572 P2X purinoceptor 3 Homo sapiens 40 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183389 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183389&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578867 313634789 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331183 C[C@H](Cn1c(=O)[nH]\c(=N/c2ccc3oc(C)cc3c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 183390 US9150546, I-564::US9688643, I-564::US9718790, I-0573 P2X purinoceptor 3 Homo sapiens 48 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183390 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183390&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578819 313634790 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331184 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(nc(=O)n1Cc1ccc(Cl)cc1)N1CCCC1=O InChI=1S/C23H23Cl2N5O3/c1-14(2)33-19-10-9-17(12-18(19)25)26-21-27-22(29-11-3-4-20(29)31)28-23(32)30(21)13-15-5-7-16(24)8-6-15/h5-10,12,14H,3-4,11,13H2,1-2H3,(H,26,27,28,32) AGOKXKCSCRKDNJ-UHFFFAOYSA-N 183391 US9150546, II-012::US9688643, II-012::US9718790, I-0576 P2X purinoceptor 3 Homo sapiens 568 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183391 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183391&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 119099073 313634791 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331185 CCN(CC)c1nc(=O)n(Cc2ccc(Cl)cc2)\c(=N\c2ccc(OC(C)C)c(Cl)c2)[nH]1 InChI=1S/C23H27Cl2N5O2/c1-5-29(6-2)21-27-22(26-18-11-12-20(19(25)13-18)32-15(3)4)30(23(31)28-21)14-16-7-9-17(24)10-8-16/h7-13,15H,5-6,14H2,1-4H3,(H,26,27,28,31) QIYDVXQPYHCHGL-UHFFFAOYSA-N 183392 US9150546, II-013::US9688643, II-013::US9718790, I-0577 P2X purinoceptor 3 Homo sapiens 430 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183392 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183392&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 119099074 313634792 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331186 CCOc1nc(=O)n(Cc2ccc(Cl)cc2)\c(=N\c2ccc(OC(C)C)c(Cl)c2)[nH]1 InChI=1S/C21H22Cl2N4O3/c1-4-29-20-25-19(24-16-9-10-18(17(23)11-16)30-13(2)3)27(21(28)26-20)12-14-5-7-15(22)8-6-14/h5-11,13H,4,12H2,1-3H3,(H,24,25,26,28) INJXKGYCADCMNE-UHFFFAOYSA-N 183393 US9150546, II-014::US9688643, II-014::US9718790, I-0578 P2X purinoceptor 3 Homo sapiens 254 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183393 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183393&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 119099075 313634793 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 331187 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(CCC(O)=O)nc(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C22H22Cl2N4O4/c1-13(2)32-18-8-7-16(11-17(18)24)25-21-26-19(9-10-20(29)30)27-22(31)28(21)12-14-3-5-15(23)6-4-14/h3-8,11,13H,9-10,12H2,1-2H3,(H,29,30)(H,25,26,27,31) HSAJOPASXWABBQ-UHFFFAOYSA-N 183394 US9150546, II-015::US9688643, II-015::US9718790, I-0579 P2X purinoceptor 3 Homo sapiens 614 7.5 37.00 C US Patent 10.7270/Q2416VV1 aid1801698 US9150546 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183394 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183394&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 119099076 313634794 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349224 CCNC(=O)Nc1cnc(Nc2ccc(OC(C)C)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H25ClFN5O3/c1-4-26-23(32)29-19-12-27-22(28-17-9-10-20(18(25)11-17)33-14(2)3)30(21(19)31)13-15-5-7-16(24)8-6-15/h5-12,14H,4,13H2,1-3H3,(H,27,28)(H2,26,29,32) HCVONQVEGXHJOH-UHFFFAOYSA-N 196330 US9212130, I-250 P2X purinoceptor 3 Homo sapiens 7 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196330 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196330&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68017270 318471677 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349225 CC(C)Oc1ccc(Nc2ncc(NS(C)(=O)=O)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C21H22ClFN4O4S/c1-13(2)31-19-9-8-16(10-17(19)23)25-21-24-11-18(26-32(3,29)30)20(28)27(21)12-14-4-6-15(22)7-5-14/h4-11,13,26H,12H2,1-3H3,(H,24,25) NQWNLRGJRPFZOD-UHFFFAOYSA-N 196332 US9212130, I-252 P2X purinoceptor 3 Homo sapiens 62 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196332 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196332&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68017272 318471678 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349226 CC(C)Oc1ccc(Nc2ncc(N(S(C)(=O)=O)S(C)(=O)=O)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C22H24ClFN4O6S2/c1-14(2)34-20-10-9-17(11-18(20)24)26-22-25-12-19(28(35(3,30)31)36(4,32)33)21(29)27(22)13-15-5-7-16(23)8-6-15/h5-12,14H,13H2,1-4H3,(H,25,26) VZZCIFSQDDQFGD-UHFFFAOYSA-N 196333 US9212130, I-253 P2X purinoceptor 3 Homo sapiens 536 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196333 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196333&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118579551 318471679 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349227 CC(C)Oc1ccc(Nc2ncc(NC(=O)C(O)=O)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C22H20ClFN4O5/c1-12(2)33-18-8-7-15(9-16(18)24)26-22-25-10-17(27-19(29)21(31)32)20(30)28(22)11-13-3-5-14(23)6-4-13/h3-10,12H,11H2,1-2H3,(H,25,26)(H,27,29)(H,31,32) UONGHTJEASBJFW-UHFFFAOYSA-N 196334 US9212130, I-254 P2X purinoceptor 3 Homo sapiens 20 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196334 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196334&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68017323 318471680 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349228 CC(C)Oc1ccc(Nc2ncc(C(=O)OC(C)(C)C)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C25H27ClFN3O4/c1-15(2)33-21-11-10-18(12-20(21)27)29-24-28-13-19(23(32)34-25(3,4)5)22(31)30(24)14-16-6-8-17(26)9-7-16/h6-13,15H,14H2,1-5H3,(H,28,29) LCCWYCXWSAOPNJ-UHFFFAOYSA-N 196335 US9212130, I-255 P2X purinoceptor 3 Homo sapiens 54 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196335 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196335&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68017324 318471681 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349229 CC(C)Oc1ccc(Nc2nccc(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C20H19ClFN3O2/c1-13(2)27-18-8-7-16(11-17(18)22)24-20-23-10-9-19(26)25(20)12-14-3-5-15(21)6-4-14/h3-11,13H,12H2,1-2H3,(H,23,24) IQWOBBGEEOCATH-UHFFFAOYSA-N 196336 US9212130, I-256 P2X purinoceptor 3 Homo sapiens 732 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196336 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196336&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 122197900 318471682 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349230 CC(C)Oc1ccc(Nc2ncc(Br)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C20H18BrClFN3O2/c1-12(2)28-18-8-7-15(9-17(18)23)25-20-24-10-16(21)19(27)26(20)11-13-3-5-14(22)6-4-13/h3-10,12H,11H2,1-2H3,(H,24,25) NNVNKRFKCUZLQW-UHFFFAOYSA-N 196337 US9212130, I-257 P2X purinoceptor 3 Homo sapiens 319 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196337 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196337&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68017322 318471683 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349231 CC(C)Oc1ccc(Nc2ncc(C(N)=O)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C21H20ClFN4O3/c1-12(2)30-18-8-7-15(9-17(18)23)26-21-25-10-16(19(24)28)20(29)27(21)11-13-3-5-14(22)6-4-13/h3-10,12H,11H2,1-2H3,(H2,24,28)(H,25,26) GHZMEQHDNWCEFY-UHFFFAOYSA-N 196338 US9212130, I-258 P2X purinoceptor 3 Homo sapiens 47 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196338 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196338&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118579552 318471684 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349232 CC(C)Oc1ccc(Nc2ncc(C#N)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C21H18ClFN4O2/c1-13(2)29-19-8-7-17(9-18(19)23)26-21-25-11-15(10-24)20(28)27(21)12-14-3-5-16(22)6-4-14/h3-9,11,13H,12H2,1-2H3,(H,25,26) LMQGJOREBCDSAM-UHFFFAOYSA-N 196339 US9212130, I-259 P2X purinoceptor 3 Homo sapiens 436 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196339 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196339&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118579553 318471685 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349233 CCCC(=O)Nc1cnc(Nc2ccc(OC(C)C)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H26ClFN4O3/c1-4-5-22(31)29-20-13-27-24(28-18-10-11-21(19(26)12-18)33-15(2)3)30(23(20)32)14-16-6-8-17(25)9-7-16/h6-13,15H,4-5,14H2,1-3H3,(H,27,28)(H,29,31) DBZPQGVFBGUQNE-UHFFFAOYSA-N 196340 US9212130, I-260 P2X purinoceptor 3 Homo sapiens 15 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196340 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196340&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118579706 318471686 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349234 CCc1nc2ccc(Nc3ncc(NC(=O)C4CCOCC4)c(=O)n3Cc3ccc(Cl)cc3)cc2s1 InChI=1S/C26H26ClN5O3S/c1-2-23-30-20-8-7-19(13-22(20)36-23)29-26-28-14-21(31-24(33)17-9-11-35-12-10-17)25(34)32(26)15-16-3-5-18(27)6-4-16/h3-8,13-14,17H,2,9-12,15H2,1H3,(H,28,29)(H,31,33) ATZLLSUYPSQXJL-UHFFFAOYSA-N 196342 US9212130, I-262 P2X purinoceptor 3 Homo sapiens 3 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196342 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196342&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 89744962 318471687 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349235 CCOC(=O)Nc1cnc(Nc2ccc(OC(C)C)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H24ClFN4O4/c1-4-32-23(31)28-19-12-26-22(27-17-9-10-20(18(25)11-17)33-14(2)3)29(21(19)30)13-15-5-7-16(24)8-6-15/h5-12,14H,4,13H2,1-3H3,(H,26,27)(H,28,31) WRLUAXOBEFHAFS-UHFFFAOYSA-N 196343 US9212130, I-263 P2X purinoceptor 3 Homo sapiens 33 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196343 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196343&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68017101 318471688 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349236 Cc1nc2ccc(Nc3ncc(NC(=O)C4CCOCC4)c(=O)n3Cc3ccc(Cl)cc3)cc2s1 InChI=1S/C25H24ClN5O3S/c1-15-28-20-7-6-19(12-22(20)35-15)29-25-27-13-21(30-23(32)17-8-10-34-11-9-17)24(33)31(25)14-16-2-4-18(26)5-3-16/h2-7,12-13,17H,8-11,14H2,1H3,(H,27,29)(H,30,32) NVGBIWGDDMSVEP-UHFFFAOYSA-N 196344 US9212130, I-264 P2X purinoceptor 3 Homo sapiens 4 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196344 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196344&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68017097 318471689 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349237 Cc1ccc(Oc2ccc(Nc3ncc(NC(=O)C4CCOCC4)c(=O)n3Cc3ccc(Cl)cc3)cc2)cn1 InChI=1S/C29H28ClN5O4/c1-19-2-9-25(16-31-19)39-24-10-7-23(8-11-24)33-29-32-17-26(34-27(36)21-12-14-38-15-13-21)28(37)35(29)18-20-3-5-22(30)6-4-20/h2-11,16-17,21H,12-15,18H2,1H3,(H,32,33)(H,34,36) NSFSMCRLIJEAOT-UHFFFAOYSA-N 196345 US9212130, I-265 P2X purinoceptor 3 Homo sapiens 1 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196345 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196345&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68017092 318471690 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349238 CC(C)Oc1ccc(Nc2ncc(C(=O)NNC=O)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C22H21ClFN5O4/c1-13(2)33-19-8-7-16(9-18(19)24)27-22-25-10-17(20(31)28-26-12-30)21(32)29(22)11-14-3-5-15(23)6-4-14/h3-10,12-13H,11H2,1-2H3,(H,25,27)(H,26,30)(H,28,31) QXISTNQQINZQSA-UHFFFAOYSA-N 196346 US9212130, I-266 P2X purinoceptor 3 Homo sapiens 55 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196346 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196346&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118579695 318471691 C06049 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349239 CC(C)Oc1ccc(Nc2ncc(NC(=O)C(C)(C)OC(C)=O)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C26H28ClFN4O5/c1-15(2)36-22-11-10-19(12-20(22)28)30-25-29-13-21(31-24(35)26(4,5)37-16(3)33)23(34)32(25)14-17-6-8-18(27)9-7-17/h6-13,15H,14H2,1-5H3,(H,29,30)(H,31,35) POOYGSVGMAKYME-UHFFFAOYSA-N 196347 US9212130, I-267 P2X purinoceptor 3 Homo sapiens 25 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196347 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196347&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68017094 318471692 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349240 CC(C)Oc1ccc(Nc2ncc(NC(=O)C(C)(C)O)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C24H26ClFN4O4/c1-14(2)34-20-10-9-17(11-18(20)26)28-23-27-12-19(29-22(32)24(3,4)33)21(31)30(23)13-15-5-7-16(25)8-6-15/h5-12,14,33H,13H2,1-4H3,(H,27,28)(H,29,32) YDCAAUVLQJTEAD-UHFFFAOYSA-N 196348 US9212130, I-268 P2X purinoceptor 3 Homo sapiens 4 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196348 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196348&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68017112 318471693 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349241 CC(C)Oc1ccc(Nc2ncc(NC(=O)CCO)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C23H24ClFN4O4/c1-14(2)33-20-8-7-17(11-18(20)25)27-23-26-12-19(28-21(31)9-10-30)22(32)29(23)13-15-3-5-16(24)6-4-15/h3-8,11-12,14,30H,9-10,13H2,1-2H3,(H,26,27)(H,28,31) MQZJOFBWROXNIT-UHFFFAOYSA-N 196349 US9212130, I-269 P2X purinoceptor 3 Homo sapiens 31 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196349 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196349&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118579707 318471694 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349242 CC(C)Oc1ccc(Nc2ncc(NC(=O)C3CCN(CC3)C(C)=O)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C28H31ClFN5O4/c1-17(2)39-25-9-8-22(14-23(25)30)32-28-31-15-24(27(38)35(28)16-19-4-6-21(29)7-5-19)33-26(37)20-10-12-34(13-11-20)18(3)36/h4-9,14-15,17,20H,10-13,16H2,1-3H3,(H,31,32)(H,33,37) AZUWQMZDQYEUJE-UHFFFAOYSA-N 196350 US9212130, I-270 P2X purinoceptor 3 Homo sapiens 10 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196350 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196350&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68017088 318471695 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349243 CC(C)Oc1ccc(Nc2ncc(C(=O)NNC(=O)OC(C)(C)C)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C26H29ClFN5O5/c1-15(2)37-21-11-10-18(12-20(21)28)30-24-29-13-19(22(34)31-32-25(36)38-26(3,4)5)23(35)33(24)14-16-6-8-17(27)9-7-16/h6-13,15H,14H2,1-5H3,(H,29,30)(H,31,34)(H,32,36) GZNSKBRBGCPJJE-UHFFFAOYSA-N 196351 US9212130, I-271 P2X purinoceptor 3 Homo sapiens 29 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196351 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196351&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118579555 318471696 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349244 CC(C)Oc1ccc(Nc2ncc(C(=O)NN)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C21H21ClFN5O3/c1-12(2)31-18-8-7-15(9-17(18)23)26-21-25-10-16(19(29)27-24)20(30)28(21)11-13-3-5-14(22)6-4-13/h3-10,12H,11,24H2,1-2H3,(H,25,26)(H,27,29) USIVTWSMDODPLL-UHFFFAOYSA-N 196352 US9212130, I-272 P2X purinoceptor 3 Homo sapiens 104 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196352 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196352&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68017099 318471697 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349245 COc1cc(ccn1)C(=O)Nc1cnc(Nc2ccc(OC(C)C)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C27H25ClFN5O4/c1-16(2)38-23-9-8-20(13-21(23)29)32-27-31-14-22(33-25(35)18-10-11-30-24(12-18)37-3)26(36)34(27)15-17-4-6-19(28)7-5-17/h4-14,16H,15H2,1-3H3,(H,31,32)(H,33,35) HRHGYSVBEHDGTM-UHFFFAOYSA-N 196353 US9212130, I-273 P2X purinoceptor 3 Homo sapiens 95 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196353 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196353&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 89634958 318471698 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349246 COc1ccc(cn1)C(=O)Nc1cnc(Nc2ccc(OC(C)C)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C27H25ClFN5O4/c1-16(2)38-23-10-9-20(12-21(23)29)32-27-31-14-22(33-25(35)18-6-11-24(37-3)30-13-18)26(36)34(27)15-17-4-7-19(28)8-5-17/h4-14,16H,15H2,1-3H3,(H,31,32)(H,33,35) XARRKDFAEBEYLC-UHFFFAOYSA-N 196354 US9212130, I-274 P2X purinoceptor 3 Homo sapiens 66 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196354 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196354&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118579696 318471699 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349247 CC(C)Oc1ccc(Nc2ncc(NC(=O)c3cc[nH]c(=O)c3)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C26H23ClFN5O4/c1-15(2)37-22-8-7-19(12-20(22)28)31-26-30-13-21(32-24(35)17-9-10-29-23(34)11-17)25(36)33(26)14-16-3-5-18(27)6-4-16/h3-13,15H,14H2,1-2H3,(H,29,34)(H,30,31)(H,32,35) HILIDHHXTWZWIY-UHFFFAOYSA-N 196355 US9212130, I-275 P2X purinoceptor 3 Homo sapiens 11 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196355 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196355&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 122197901 318471700 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349248 CC(C)Oc1ccc(Nc2ncc(NC(=O)c3ccc(=O)[nH]c3)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C26H23ClFN5O4/c1-15(2)37-22-9-8-19(11-20(22)28)31-26-30-13-21(32-24(35)17-5-10-23(34)29-12-17)25(36)33(26)14-16-3-6-18(27)7-4-16/h3-13,15H,14H2,1-2H3,(H,29,34)(H,30,31)(H,32,35) YJMFWXFMNRGRJS-UHFFFAOYSA-N 196356 US9212130, I-276 P2X purinoceptor 3 Homo sapiens 32 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196356 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196356&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 77387284 318471701 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349249 CC(C)Oc1ccc(Nc2ncc(NC(N)=O)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C21H21ClFN5O3/c1-12(2)31-18-8-7-15(9-16(18)23)26-21-25-10-17(27-20(24)30)19(29)28(21)11-13-3-5-14(22)6-4-13/h3-10,12H,11H2,1-2H3,(H,25,26)(H3,24,27,30) DVBHLQKCAIHXHA-UHFFFAOYSA-N 196357 US9212130, I-277 P2X purinoceptor 3 Homo sapiens 49 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196357 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196357&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68017412 318471702 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349250 CC(C)Oc1ccc(Nc2ncc(NC(=O)N3CCOCC3)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C25H27ClFN5O4/c1-16(2)36-22-8-7-19(13-20(22)27)29-24-28-14-21(30-25(34)31-9-11-35-12-10-31)23(33)32(24)15-17-3-5-18(26)6-4-17/h3-8,13-14,16H,9-12,15H2,1-2H3,(H,28,29)(H,30,34) BNYLBWZEXYTLPY-UHFFFAOYSA-N 196358 US9212130, I-278 P2X purinoceptor 3 Homo sapiens 16 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196358 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196358&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68017409 318471703 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349251 CC(C)Oc1ccc(Nc2ncc(NC(=O)c3ccn(C)c(=O)c3)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C27H25ClFN5O4/c1-16(2)38-23-9-8-20(13-21(23)29)31-27-30-14-22(32-25(36)18-10-11-33(3)24(35)12-18)26(37)34(27)15-17-4-6-19(28)7-5-17/h4-14,16H,15H2,1-3H3,(H,30,31)(H,32,36) CGKBGYBXUUGOHM-UHFFFAOYSA-N 196359 US9212130, I-279 P2X purinoceptor 3 Homo sapiens 139 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196359 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196359&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68017405 318471704 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349252 Cc1nc2ccc(Nc3ncc(C)c(=O)n3Cc3ccc(Cl)cc3)cc2s1 InChI=1S/C20H17ClN4OS/c1-12-10-22-20(24-16-7-8-17-18(9-16)27-13(2)23-17)25(19(12)26)11-14-3-5-15(21)6-4-14/h3-10H,11H2,1-2H3,(H,22,24) JDENGEWOANKKQI-UHFFFAOYSA-N 196360 US9212130, I-280 P2X purinoceptor 3 Homo sapiens 237 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196360 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196360&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68017406 318471705 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349253 CCOC(=O)c1cn(Cc2ccc(Cl)cc2)c(Nc2ccc3nc(C)sc3c2)nc1=O InChI=1S/C22H19ClN4O3S/c1-3-30-21(29)17-12-27(11-14-4-6-15(23)7-5-14)22(26-20(17)28)25-16-8-9-18-19(10-16)31-13(2)24-18/h4-10,12H,3,11H2,1-2H3,(H,25,26,28) CLHVMZPUJJWLIC-UHFFFAOYSA-N 196361 US9212130, I-282 P2X purinoceptor 3 Homo sapiens 272 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196361 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196361&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68017401 318471706 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349254 Cc1nc2ccc(Nc3nc(=O)c(cn3Cc3ccc(Cl)cc3)C(=O)NC3CCOCC3)cc2s1 InChI=1S/C25H24ClN5O3S/c1-15-27-21-7-6-19(12-22(21)35-15)29-25-30-24(33)20(23(32)28-18-8-10-34-11-9-18)14-31(25)13-16-2-4-17(26)5-3-16/h2-7,12,14,18H,8-11,13H2,1H3,(H,28,32)(H,29,30,33) RFULHYICTIXNHL-UHFFFAOYSA-N 196364 US9212130, I-286 P2X purinoceptor 3 Homo sapiens 8 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196364 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196364&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118579556 318471707 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349255 CC(C)Oc1ccc(Nc2ncc(NC(=O)C3COC(C)(C)OC3)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C27H30ClFN4O5/c1-16(2)38-23-10-9-20(11-21(23)29)31-26-30-12-22(32-24(34)18-14-36-27(3,4)37-15-18)25(35)33(26)13-17-5-7-19(28)8-6-17/h5-12,16,18H,13-15H2,1-4H3,(H,30,31)(H,32,34) YQBGEHTUPQIGTQ-UHFFFAOYSA-N 196365 US9212130, I-287 P2X purinoceptor 3 Homo sapiens 23 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196365 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196365&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118579712 318471708 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349256 CC(C)Oc1ccc(Nc2ncc(NC(=O)C(CO)CO)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C24H26ClFN4O5/c1-14(2)35-21-8-7-18(9-19(21)26)28-24-27-10-20(29-22(33)16(12-31)13-32)23(34)30(24)11-15-3-5-17(25)6-4-15/h3-10,14,16,31-32H,11-13H2,1-2H3,(H,27,28)(H,29,33) ONDCUQVSXINORB-UHFFFAOYSA-N 196366 US9212130, I-288 P2X purinoceptor 3 Homo sapiens 17 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196366 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196366&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118579700 318471709 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349257 CC(C)Oc1ccc(Nc2ncc(NC(=O)NC3CCOCC3)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C26H29ClFN5O4/c1-16(2)37-23-8-7-20(13-21(23)28)30-25-29-14-22(32-26(35)31-19-9-11-36-12-10-19)24(34)33(25)15-17-3-5-18(27)6-4-17/h3-8,13-14,16,19H,9-12,15H2,1-2H3,(H,29,30)(H2,31,32,35) ROCUOQVBCCJGKW-UHFFFAOYSA-N 196367 US9212130, I-289 P2X purinoceptor 3 Homo sapiens 7 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196367 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196367&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118579702 318471710 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349258 CC(C)Oc1ccc(Nc2ncc(NC(=O)C(C)(C)C#N)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C25H25ClFN5O3/c1-15(2)35-21-10-9-18(11-19(21)27)30-24-29-12-20(31-23(34)25(3,4)14-28)22(33)32(24)13-16-5-7-17(26)8-6-16/h5-12,15H,13H2,1-4H3,(H,29,30)(H,31,34) FLFYOIOPBSDLIG-UHFFFAOYSA-N 196368 US9212130, I-290 P2X purinoceptor 3 Homo sapiens 23 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196368 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196368&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118579701 318471711 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349259 CC(=O)Nc1cnc(Nc2ccc(Oc3ccc(C)nc3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H22ClN5O3/c1-16-3-10-22(13-27-16)34-21-11-8-20(9-12-21)30-25-28-14-23(29-17(2)32)24(33)31(25)15-18-4-6-19(26)7-5-18/h3-14H,15H2,1-2H3,(H,28,30)(H,29,32) ZYRNRFSTCMJJEM-UHFFFAOYSA-N 196369 US9212130, I-291 P2X purinoceptor 3 Homo sapiens 43 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196369 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196369&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68017264 318471712 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349260 Cc1ccc(Oc2ccc(Nc3ncc(N)c(=O)n3Cc3ccc(Cl)cc3)cc2)cn1 InChI=1S/C23H20ClN5O2/c1-15-2-9-20(12-26-15)31-19-10-7-18(8-11-19)28-23-27-13-21(25)22(30)29(23)14-16-3-5-17(24)6-4-16/h2-13H,14,25H2,1H3,(H,27,28) JHQSNQSSCJPLKW-UHFFFAOYSA-N 196370 US9212130, I-292 P2X purinoceptor 3 Homo sapiens 433 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196370 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196370&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68017258 318471713 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349261 CC(=O)OC(C)(C)C(=O)Nc1cnc(Nc2ccc(Oc3ccc(C)nc3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C29H28ClN5O5/c1-18-5-12-24(15-31-18)39-23-13-10-22(11-14-23)33-28-32-16-25(34-27(38)29(3,4)40-19(2)36)26(37)35(28)17-20-6-8-21(30)9-7-20/h5-16H,17H2,1-4H3,(H,32,33)(H,34,38) NUIIRMLVEBUJKP-UHFFFAOYSA-N 196371 US9212130, I-293 P2X purinoceptor 3 Homo sapiens 14 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196371 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196371&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68017253 318471714 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349262 Cc1ccc(Oc2ccc(Nc3ncc(NC(=O)C4COC(C)(C)OC4)c(=O)n3Cc3ccc(Cl)cc3)cc2)cn1 InChI=1S/C30H30ClN5O5/c1-19-4-11-25(14-32-19)41-24-12-9-23(10-13-24)34-29-33-15-26(35-27(37)21-17-39-30(2,3)40-18-21)28(38)36(29)16-20-5-7-22(31)8-6-20/h4-15,21H,16-18H2,1-3H3,(H,33,34)(H,35,37) IQPVOGTTXKTILA-UHFFFAOYSA-N 196372 US9212130, I-294 P2X purinoceptor 3 Homo sapiens 9 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196372 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196372&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118579697 318471715 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349263 Cc1ccc(Oc2ccc(Nc3ncc(NC(=O)C(C)(C)O)c(=O)n3Cc3ccc(Cl)cc3)cc2)cn1 InChI=1S/C27H26ClN5O4/c1-17-4-11-22(14-29-17)37-21-12-9-20(10-13-21)31-26-30-15-23(32-25(35)27(2,3)36)24(34)33(26)16-18-5-7-19(28)8-6-18/h4-15,36H,16H2,1-3H3,(H,30,31)(H,32,35) VOFMKFSKGXTQFF-UHFFFAOYSA-N 196373 US9212130, I-295 P2X purinoceptor 3 Homo sapiens 2 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196373 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196373&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68017268 318471716 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349264 CC(=O)Nc1cnc(Nc2ccc3nc(C)sc3c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C21H18ClN5O2S/c1-12(28)24-18-10-23-21(26-16-7-8-17-19(9-16)30-13(2)25-17)27(20(18)29)11-14-3-5-15(22)6-4-14/h3-10H,11H2,1-2H3,(H,23,26)(H,24,28) XMYFTCXACGNAEF-UHFFFAOYSA-N 196375 US9212130, I-297 P2X purinoceptor 3 Homo sapiens 112 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196375 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196375&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68017275 318471718 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349265 Cc1ccc(Oc2ccc(Nc3ncc(NC(=O)C(CO)CO)c(=O)n3Cc3ccc(Cl)cc3)cc2)cn1 InChI=1S/C27H26ClN5O5/c1-17-2-9-23(12-29-17)38-22-10-7-21(8-11-22)31-27-30-13-24(32-25(36)19(15-34)16-35)26(37)33(27)14-18-3-5-20(28)6-4-18/h2-13,19,34-35H,14-16H2,1H3,(H,30,31)(H,32,36) UDXYDKVTYNXTLJ-UHFFFAOYSA-N 196374 BDBM196434::US9212130, I-298 P2X purinoceptor 3 Homo sapiens 8 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196374 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196374&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118579711 318471717 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349266 Cc1nc2ccc(Nc3nc(=O)c(cn3Cc3ccc(Cl)cc3)C(=O)NCCCO)cc2s1 InChI=1S/C23H22ClN5O3S/c1-14-26-19-8-7-17(11-20(19)33-14)27-23-28-22(32)18(21(31)25-9-2-10-30)13-29(23)12-15-3-5-16(24)6-4-15/h3-8,11,13,30H,2,9-10,12H2,1H3,(H,25,31)(H,27,28,32) CMBYEVOLGKBKLR-UHFFFAOYSA-N 196377 US9212130, I-299 P2X purinoceptor 3 Homo sapiens 111 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196377 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196377&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68017274 318471719 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349267 COCCCNC(=O)c1cn(Cc2ccc(Cl)cc2)c(Nc2ccc3nc(C)sc3c2)nc1=O InChI=1S/C24H24ClN5O3S/c1-15-27-20-9-8-18(12-21(20)34-15)28-24-29-23(32)19(22(31)26-10-3-11-33-2)14-30(24)13-16-4-6-17(25)7-5-16/h4-9,12,14H,3,10-11,13H2,1-2H3,(H,26,31)(H,28,29,32) AFLSKGUQFLOENU-UHFFFAOYSA-N 196378 US9212130, I-300 P2X purinoceptor 3 Homo sapiens 164 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196378 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196378&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118579557 318471720 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349268 Cc1nc2ccc(Nc3nc(=O)c(cn3Cc3ccc(Cl)cc3)C(=O)NCCC#N)cc2s1 InChI=1S/C23H19ClN6O2S/c1-14-27-19-8-7-17(11-20(19)33-14)28-23-29-22(32)18(21(31)26-10-2-9-25)13-30(23)12-15-3-5-16(24)6-4-15/h3-8,11,13H,2,10,12H2,1H3,(H,26,31)(H,28,29,32) OINOSOYRIAGLBW-UHFFFAOYSA-N 196379 US9212130, I-301 P2X purinoceptor 3 Homo sapiens 123 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196379 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196379&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 89634803 318471721 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349269 CC(=O)N1CCC(CC1)NC(=O)c1cn(Cc2ccc(Cl)cc2)c(Nc2ccc3nc(C)sc3c2)nc1=O InChI=1S/C27H27ClN6O3S/c1-16-29-23-8-7-21(13-24(23)38-16)31-27-32-26(37)22(15-34(27)14-18-3-5-19(28)6-4-18)25(36)30-20-9-11-33(12-10-20)17(2)35/h3-8,13,15,20H,9-12,14H2,1-2H3,(H,30,36)(H,31,32,37) ZLUHYGAMDMVLGT-UHFFFAOYSA-N 196380 US9212130, I-302 P2X purinoceptor 3 Homo sapiens 87 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196380 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196380&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68017263 318471722 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349270 COC(=O)c1cncc(Oc2ccc(Nc3ncc(NC(=O)C4CCOCC4)c(=O)n3Cc3ccc(Cl)cc3)cc2)c1 InChI=1S/C30H28ClN5O6/c1-40-29(39)21-14-25(16-32-15-21)42-24-8-6-23(7-9-24)34-30-33-17-26(35-27(37)20-10-12-41-13-11-20)28(38)36(30)18-19-2-4-22(31)5-3-19/h2-9,14-17,20H,10-13,18H2,1H3,(H,33,34)(H,35,37) NPFRLWSLFSIPLW-UHFFFAOYSA-N 196382 US9212130, I-304 P2X purinoceptor 3 Homo sapiens 2 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196382 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196382&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 71661257 318471723 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349271 OC(=O)c1cncc(Oc2ccc(Nc3ncc(NC(=O)C4CCOCC4)c(=O)n3Cc3ccc(Cl)cc3)cc2)c1 InChI=1S/C29H26ClN5O6/c30-21-3-1-18(2-4-21)17-35-27(37)25(34-26(36)19-9-11-40-12-10-19)16-32-29(35)33-22-5-7-23(8-6-22)41-24-13-20(28(38)39)14-31-15-24/h1-8,13-16,19H,9-12,17H2,(H,32,33)(H,34,36)(H,38,39) ZYHFWXNADNMYEJ-UHFFFAOYSA-N 196383 US9212130, I-305 P2X purinoceptor 3 Homo sapiens 4 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196383 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196383&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68017108 318471724 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349272 Cc1nc2ccc(Nc3ncc(Br)c(=O)n3Cc3ccc(Cl)cc3)cc2s1 InChI=1S/C19H14BrClN4OS/c1-11-23-16-7-6-14(8-17(16)27-11)24-19-22-9-15(20)18(26)25(19)10-12-2-4-13(21)5-3-12/h2-9H,10H2,1H3,(H,22,24) HPFVEDYMTTWLFH-UHFFFAOYSA-N 196384 US9212130, I-306 P2X purinoceptor 3 Homo sapiens 207 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196384 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196384&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68017109 318471725 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349273 CC(C)NC(=O)c1cn(Cc2ccc(Cl)cc2)c(Nc2ccc3nc(C)sc3c2)nc1=O InChI=1S/C23H22ClN5O2S/c1-13(2)25-21(30)18-12-29(11-15-4-6-16(24)7-5-15)23(28-22(18)31)27-17-8-9-19-20(10-17)32-14(3)26-19/h4-10,12-13H,11H2,1-3H3,(H,25,30)(H,27,28,31) WLQNBGAFJXJBBZ-UHFFFAOYSA-N 196385 US9212130, I-307 P2X purinoceptor 3 Homo sapiens 40 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196385 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196385&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 89634942 318471726 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349274 Cc1nc2ccc(Nc3nc(=O)c(cn3Cc3ccc(Cl)cc3)C(=O)NC3COC3)cc2s1 InChI=1S/C23H20ClN5O3S/c1-13-25-19-7-6-16(8-20(19)33-13)27-23-28-22(31)18(21(30)26-17-11-32-12-17)10-29(23)9-14-2-4-15(24)5-3-14/h2-8,10,17H,9,11-12H2,1H3,(H,26,30)(H,27,28,31) FMLVFJNZISLAEK-UHFFFAOYSA-N 196386 US9212130, I-308 P2X purinoceptor 3 Homo sapiens 133 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196386 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196386&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68017111 318471727 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349275 Cc1nc2ccc(Nc3nc(=O)c(cn3Cc3ccc(Cl)cc3)C(=O)NC3CC3)cc2s1 InChI=1S/C23H20ClN5O2S/c1-13-25-19-9-8-17(10-20(19)32-13)27-23-28-22(31)18(21(30)26-16-6-7-16)12-29(23)11-14-2-4-15(24)5-3-14/h2-5,8-10,12,16H,6-7,11H2,1H3,(H,26,30)(H,27,28,31) DSTIXJOFQYEFGR-UHFFFAOYSA-N 196387 US9212130, I-309 P2X purinoceptor 3 Homo sapiens 61 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196387 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196387&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68017117 318471728 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349276 CN(C)NC(=O)c1cn(Cc2ccc(Cl)cc2)c(Nc2ccc3nc(C)sc3c2)nc1=O InChI=1S/C22H21ClN6O2S/c1-13-24-18-9-8-16(10-19(18)32-13)25-22-26-20(30)17(21(31)27-28(2)3)12-29(22)11-14-4-6-15(23)7-5-14/h4-10,12H,11H2,1-3H3,(H,27,31)(H,25,26,30) FYBAFVXPBQQWHD-UHFFFAOYSA-N 196388 US9212130, I-310 P2X purinoceptor 3 Homo sapiens 132 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196388 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196388&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 56836219 318471729 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349277 Fc1cc(Oc2ccc(Nc3ncc(NC(=O)C4CCOCC4)c(=O)n3Cc3ccc(Cl)cc3)cc2)cnc1Cl InChI=1S/C28H24Cl2FN5O4/c29-19-3-1-17(2-4-19)16-36-27(38)24(35-26(37)18-9-11-39-12-10-18)15-33-28(36)34-20-5-7-21(8-6-20)40-22-13-23(31)25(30)32-14-22/h1-8,13-15,18H,9-12,16H2,(H,33,34)(H,35,37) RURMEKBLRVDTLI-UHFFFAOYSA-N 196389 US9212130, I-311 P2X purinoceptor 3 Homo sapiens 4 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196389 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196389&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 89744959 318471730 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349278 CSc1ccc(Cn2c(Nc3ccc4nc(C)sc4c3)ncc(NC(=O)C3CCOCC3)c2=O)cc1 InChI=1S/C26H27N5O3S2/c1-16-28-21-8-5-19(13-23(21)36-16)29-26-27-14-22(30-24(32)18-9-11-34-12-10-18)25(33)31(26)15-17-3-6-20(35-2)7-4-17/h3-8,13-14,18H,9-12,15H2,1-2H3,(H,27,29)(H,30,32) ISQJMNFKBGYXRR-UHFFFAOYSA-N 196390 US9212130, I-312 P2X purinoceptor 3 Homo sapiens 11 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196390 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196390&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 89635358 318471731 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349279 Cc1ncc(Oc2ccc(Nc3ncc(NC(=O)C4CCOCC4)c(=O)n3Cc3ccc(Cl)cc3)cc2)cc1F InChI=1S/C29H27ClFN5O4/c1-18-25(31)14-24(15-32-18)40-23-8-6-22(7-9-23)34-29-33-16-26(35-27(37)20-10-12-39-13-11-20)28(38)36(29)17-19-2-4-21(30)5-3-19/h2-9,14-16,20H,10-13,17H2,1H3,(H,33,34)(H,35,37) ZVPQVQJLRDZIEG-UHFFFAOYSA-N 196391 US9212130, I-313 P2X purinoceptor 3 Homo sapiens 3 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196391 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196391&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118579704 318471732 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349280 CCn1c(=O)cc(Nc2ccc(Oc3cncc(c3)C(=O)OC)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H23ClN4O5/c1-3-30-24(32)13-23(31(26(30)34)16-17-4-6-19(27)7-5-17)29-20-8-10-21(11-9-20)36-22-12-18(14-28-15-22)25(33)35-2/h4-15,29H,3,16H2,1-2H3 CULUFVRCYXIIPK-UHFFFAOYSA-N 196392 US9212130, I-314 P2X purinoceptor 3 Homo sapiens 35 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196392 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196392&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 122197902 318471733 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349281 CCn1c(=O)cc(Nc2ccc(Oc3cncc(c3)C(O)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H21ClN4O5/c1-2-29-23(31)12-22(30(25(29)34)15-16-3-5-18(26)6-4-16)28-19-7-9-20(10-8-19)35-21-11-17(24(32)33)13-27-14-21/h3-14,28H,2,15H2,1H3,(H,32,33) JSPXJADQVJHJKX-UHFFFAOYSA-N 196393 US9212130, I-315 P2X purinoceptor 3 Homo sapiens 6 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196393 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196393&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 122197903 318471734 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349282 CCn1c(=O)cc(Nc2ccc(Oc3ccnc(c3)C(=O)OC)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H23ClN4O5/c1-3-30-24(32)15-23(31(26(30)34)16-17-4-6-18(27)7-5-17)29-19-8-10-20(11-9-19)36-21-12-13-28-22(14-21)25(33)35-2/h4-15,29H,3,16H2,1-2H3 AAGLKYQMOXIBDS-UHFFFAOYSA-N 196394 US9212130, I-316 P2X purinoceptor 3 Homo sapiens 9 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196394 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196394&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 77387282 318471735 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349283 CCn1c(=O)cc(Nc2ccc(Oc3ccnc(c3)C(O)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H21ClN4O5/c1-2-29-23(31)14-22(30(25(29)34)15-16-3-5-17(26)6-4-16)28-18-7-9-19(10-8-18)35-20-11-12-27-21(13-20)24(32)33/h3-14,28H,2,15H2,1H3,(H,32,33) CMHLBSGBYSOXAO-UHFFFAOYSA-N 196395 US9212130, I-317 P2X purinoceptor 3 Homo sapiens 3 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196395 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196395&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 122197904 318471736 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349284 Cc1nc2ccc(Nc3ncc(NC(=O)OC(C)(C)C)c(=O)n3Cc3ccc(Cl)cc3)cc2s1 InChI=1S/C24H24ClN5O3S/c1-14-27-18-10-9-17(11-20(18)34-14)28-22-26-12-19(29-23(32)33-24(2,3)4)21(31)30(22)13-15-5-7-16(25)8-6-15/h5-12H,13H2,1-4H3,(H,26,28)(H,29,32) MUUUPKPQDOLNNJ-UHFFFAOYSA-N 196396 US9212130, I-318 P2X purinoceptor 3 Homo sapiens 9 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196396 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196396&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118579709 318471737 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349285 Cc1nc2ccc(Nc3ncc(NC(=O)OCc4ccccc4)c(=O)n3Cc3ccc(Cl)cc3)cc2s1 InChI=1S/C27H22ClN5O3S/c1-17-30-22-12-11-21(13-24(22)37-17)31-26-29-14-23(32-27(35)36-16-19-5-3-2-4-6-19)25(34)33(26)15-18-7-9-20(28)10-8-18/h2-14H,15-16H2,1H3,(H,29,31)(H,32,35) CICZWABLEDFVSB-UHFFFAOYSA-N 196397 US9212130, I-319 P2X purinoceptor 3 Homo sapiens 105 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196397 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196397&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 89634809 318471738 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349286 CCC1C(=O)N\C(=N/c2ccc(OC(C)C)cc2)N(Cc2ccc(Cl)cc2)C1=O InChI=1S/C22H24ClN3O3/c1-4-19-20(27)25-22(24-17-9-11-18(12-10-17)29-14(2)3)26(21(19)28)13-15-5-7-16(23)8-6-15/h5-12,14,19H,4,13H2,1-3H3,(H,24,25,27) XGPQUZZKSLWFAZ-UHFFFAOYSA-N 196399 US9212130, I-323 P2X purinoceptor 3 Homo sapiens 207 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196399 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196399&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118579558 318471739 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349287 CCC1(CC)C(=O)N\C(=N/c2ccc(OC(C)C)cc2)N(Cc2ccc(Cl)cc2)C1=O InChI=1S/C24H28ClN3O3/c1-5-24(6-2)21(29)27-23(26-19-11-13-20(14-12-19)31-16(3)4)28(22(24)30)15-17-7-9-18(25)10-8-17/h7-14,16H,5-6,15H2,1-4H3,(H,26,27,29) BGQVJXBPHUBKEL-UHFFFAOYSA-N 196403 US9212130, I-327 P2X purinoceptor 3 Homo sapiens 867 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196403 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196403&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68016936 318471740 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349288 CC(C)Oc1ccc(Nc2nc(C)c(Cc3ccccc3)c(=O)n2Cc2ccc(Cl)cc2)cc1 InChI=1S/C28H28ClN3O2/c1-19(2)34-25-15-13-24(14-16-25)31-28-30-20(3)26(17-21-7-5-4-6-8-21)27(33)32(28)18-22-9-11-23(29)12-10-22/h4-16,19H,17-18H2,1-3H3,(H,30,31) XMOCQSQYEOIEDE-UHFFFAOYSA-N 196406 US9212130, I-330 P2X purinoceptor 3 Homo sapiens 350 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196406 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196406&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118579561 318471741 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349289 CC(C)NC(=O)c1c(O)[nH]\c(=N/c2ccc(OC(C)C)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H27ClN4O4/c1-14(2)26-21(30)20-22(31)28-24(27-18-9-11-19(12-10-18)33-15(3)4)29(23(20)32)13-16-5-7-17(25)8-6-16/h5-12,14-15,31H,13H2,1-4H3,(H,26,30)(H,27,28) BPPURWLTFULGLD-UHFFFAOYSA-N 196407 US9212130, I-332 P2X purinoceptor 3 Homo sapiens 504 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196407 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196407&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 122197905 318471742 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349290 COC(=O)CCNC(=O)c1c(O)[nH]\c(=N/c2ccc(OC(C)C)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H27ClN4O6/c1-15(2)36-19-10-8-18(9-11-19)28-25-29-23(33)21(22(32)27-13-12-20(31)35-3)24(34)30(25)14-16-4-6-17(26)7-5-16/h4-11,15,33H,12-14H2,1-3H3,(H,27,32)(H,28,29) QYSVEKWFAFLDKW-UHFFFAOYSA-N 196408 US9212130, I-333 P2X purinoceptor 3 Homo sapiens 115 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196408 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196408&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 122197906 318471743 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349291 CCOC(=O)c1c(O)[nH]\c(=N/c2ccc(OC(C)C)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H24ClN3O5/c1-4-31-22(30)19-20(28)26-23(25-17-9-11-18(12-10-17)32-14(2)3)27(21(19)29)13-15-5-7-16(24)8-6-15/h5-12,14,28H,4,13H2,1-3H3,(H,25,26) NQNUCTNKJZLHJY-UHFFFAOYSA-N 196409 US9212130, I-334 P2X purinoceptor 3 Homo sapiens 188 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196409 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196409&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 122197907 318471744 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349292 CC(C)Oc1ccc(cc1)\N=c1/[nH]c(O)c(NC(C)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C22H23ClN4O4/c1-13(2)31-18-10-8-17(9-11-18)25-22-26-20(29)19(24-14(3)28)21(30)27(22)12-15-4-6-16(23)7-5-15/h4-11,13,29H,12H2,1-3H3,(H,24,28)(H,25,26) FGMQBFQGTVIINC-UHFFFAOYSA-N 196413 US9212130, I-339 P2X purinoceptor 3 Homo sapiens 518 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196413 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196413&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 122197908 318471745 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349293 CC(C)Oc1ccc(cc1)\N=c1/[nH]c(O)c(NC(=O)C(C)C)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C24H27ClN4O4/c1-14(2)21(30)27-20-22(31)28-24(26-18-9-11-19(12-10-18)33-15(3)4)29(23(20)32)13-16-5-7-17(25)8-6-16/h5-12,14-15,31H,13H2,1-4H3,(H,26,28)(H,27,30) LHRKURKRZCIWED-UHFFFAOYSA-N 196415 US9212130, I-341 P2X purinoceptor 3 Homo sapiens 681 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196415 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196415&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 122197909 318471746 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349294 Cc1nc2ccc(Nc3nc(C)cc(=O)n3Cc3ccc(Cl)cc3)cc2s1 InChI=1S/C20H17ClN4OS/c1-12-9-19(26)25(11-14-3-5-15(21)6-4-14)20(22-12)24-16-7-8-17-18(10-16)27-13(2)23-17/h3-10H,11H2,1-2H3,(H,22,24) YUYIXPLTLLDFPR-UHFFFAOYSA-N 196416 US9212130, I-343 P2X purinoceptor 3 Homo sapiens 694 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196416 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196416&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 122197910 318471747 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349295 CCOC(=O)c1c(C)nc(Nc2ccc3nc(C)sc3c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H21ClN4O3S/c1-4-31-22(30)20-13(2)25-23(27-17-9-10-18-19(11-17)32-14(3)26-18)28(21(20)29)12-15-5-7-16(24)8-6-15/h5-11H,4,12H2,1-3H3,(H,25,27) RNBJTMSLCTZHTO-UHFFFAOYSA-N 196417 US9212130, I-345 P2X purinoceptor 3 Homo sapiens 273 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196417 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196417&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68017127 318471748 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349296 Cc1nc2ccc(Nc3nc(C)c(C(N)=O)c(=O)n3Cc3ccc(Cl)cc3)cc2s1 InChI=1S/C21H18ClN5O2S/c1-11-18(19(23)28)20(29)27(10-13-3-5-14(22)6-4-13)21(24-11)26-15-7-8-16-17(9-15)30-12(2)25-16/h3-9H,10H2,1-2H3,(H2,23,28)(H,24,26) KSRYBMYKPHYNQP-UHFFFAOYSA-N 196419 US9212130, I-347 P2X purinoceptor 3 Homo sapiens 182 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196419 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196419&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 89634813 318471749 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349297 Cc1nc2ccc(Nc3nc(C)c(NC(=O)OC(C)(C)C)c(=O)n3Cc3ccc(Cl)cc3)cc2s1 InChI=1S/C25H26ClN5O3S/c1-14-21(30-24(33)34-25(3,4)5)22(32)31(13-16-6-8-17(26)9-7-16)23(27-14)29-18-10-11-19-20(12-18)35-15(2)28-19/h6-12H,13H2,1-5H3,(H,27,29)(H,30,33) XWNRRNIBXHOVJE-UHFFFAOYSA-N 196420 US9212130, I-348 P2X purinoceptor 3 Homo sapiens 105 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196420 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196420&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 89634812 318471750 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349298 Cc1nc2ccc(Nc3nc(C)c(Br)c(=O)n3Cc3ccc(Cl)cc3)cc2s1 InChI=1S/C20H16BrClN4OS/c1-11-18(21)19(27)26(10-13-3-5-14(22)6-4-13)20(23-11)25-15-7-8-16-17(9-15)28-12(2)24-16/h3-9H,10H2,1-2H3,(H,23,25) LZUSAOIIQCQWLJ-UHFFFAOYSA-N 196421 US9212130, I-349 P2X purinoceptor 3 Homo sapiens 280 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196421 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196421&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68017414 318471751 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349299 Cc1nc2ccc(Nc3nc(C)c(C=C)c(=O)n3Cc3ccc(Cl)cc3)cc2s1 InChI=1S/C22H19ClN4OS/c1-4-18-13(2)24-22(26-17-9-10-19-20(11-17)29-14(3)25-19)27(21(18)28)12-15-5-7-16(23)8-6-15/h4-11H,1,12H2,2-3H3,(H,24,26) UENJOPXGRSZDGL-UHFFFAOYSA-N 196422 US9212130, I-350 P2X purinoceptor 3 Homo sapiens 385 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196422 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196422&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68017408 318471752 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349300 CCc1c(C)nc(Nc2ccc3nc(C)sc3c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C22H21ClN4OS/c1-4-18-13(2)24-22(26-17-9-10-19-20(11-17)29-14(3)25-19)27(21(18)28)12-15-5-7-16(23)8-6-15/h5-11H,4,12H2,1-3H3,(H,24,26) ZIKSGGNJJUSOSE-UHFFFAOYSA-N 196423 US9212130, I-351 P2X purinoceptor 3 Homo sapiens 146 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196423 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196423&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68017133 318471753 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349301 COC(=O)CCCn1c(=O)cc(Nc2ccc3nc(C)sc3c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H23ClN4O4S/c1-15-26-19-10-9-18(12-20(19)34-15)27-21-13-22(30)28(11-3-4-23(31)33-2)24(32)29(21)14-16-5-7-17(25)8-6-16/h5-10,12-13,27H,3-4,11,14H2,1-2H3 DHZIGKYQJDTWLU-UHFFFAOYSA-N 196424 US9212130, I-352 P2X purinoceptor 3 Homo sapiens 24 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196424 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196424&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 77387240 318471754 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349302 Cc1nc2ccc(Nc3cc(=O)n(CCOC4CCCCO4)c(=O)n3Cc3ccc(Cl)cc3)cc2s1 InChI=1S/C26H27ClN4O4S/c1-17-28-21-10-9-20(14-22(21)36-17)29-23-15-24(32)30(11-13-35-25-4-2-3-12-34-25)26(33)31(23)16-18-5-7-19(27)8-6-18/h5-10,14-15,25,29H,2-4,11-13,16H2,1H3 XOXXESRXRZQZID-UHFFFAOYSA-N 196425 US9212130, I-353 P2X purinoceptor 3 Homo sapiens 9 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196425 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196425&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 77387236 318471755 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349303 Cc1nc2ccc(Nc3cc(=O)n(CCCC(O)=O)c(=O)n3Cc3ccc(Cl)cc3)cc2s1 InChI=1S/C23H21ClN4O4S/c1-14-25-18-9-8-17(11-19(18)33-14)26-20-12-21(29)27(10-2-3-22(30)31)23(32)28(20)13-15-4-6-16(24)7-5-15/h4-9,11-12,26H,2-3,10,13H2,1H3,(H,30,31) LUFABAAUOWLYPU-UHFFFAOYSA-N 196426 US9212130, I-354 P2X purinoceptor 3 Homo sapiens 94 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196426 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196426&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 77387242 318471756 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349304 Cc1nc2ccc(Nc3cc(=O)n(CCO)c(=O)n3Cc3ccc(Cl)cc3)cc2s1 InChI=1S/C21H19ClN4O3S/c1-13-23-17-7-6-16(10-18(17)30-13)24-19-11-20(28)25(8-9-27)21(29)26(19)12-14-2-4-15(22)5-3-14/h2-7,10-11,24,27H,8-9,12H2,1H3 IPOSHTYERHXXPX-UHFFFAOYSA-N 196427 US9212130, I-355 P2X purinoceptor 3 Homo sapiens 57 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196427 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196427&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 77387241 318471757 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349305 COC(=O)c1cccc(Oc2ccc(Nc3ncc(NC(=O)C4CCOCC4)c(=O)n3Cc3ccc(Cl)cc3)cc2)c1 InChI=1S/C31H29ClN4O6/c1-40-30(39)22-3-2-4-26(17-22)42-25-11-9-24(10-12-25)34-31-33-18-27(35-28(37)21-13-15-41-16-14-21)29(38)36(31)19-20-5-7-23(32)8-6-20/h2-12,17-18,21H,13-16,19H2,1H3,(H,33,34)(H,35,37) CXZKTQNNMDFKFQ-UHFFFAOYSA-N 196429 US9212130, I-357 P2X purinoceptor 3 Homo sapiens 3 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196429 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196429&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68017105 318471759 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349306 CC(=O)N1CCC(CC1)C(=O)Nc1cnc(Nc2ccc3nc(C)sc3c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C27H27ClN6O3S/c1-16-30-22-8-7-21(13-24(22)38-16)31-27-29-14-23(26(37)34(27)15-18-3-5-20(28)6-4-18)32-25(36)19-9-11-33(12-10-19)17(2)35/h3-8,13-14,19H,9-12,15H2,1-2H3,(H,29,31)(H,32,36) RXMCLPXWNZFJFG-UHFFFAOYSA-N 196428 BDBM196435::US9212130, I-358 P2X purinoceptor 3 Homo sapiens 16 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196428 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196428&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68017103 318471758 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349307 OC(=O)c1cccc(Oc2ccc(Nc3ncc(NC(=O)C4CCOCC4)c(=O)n3Cc3ccc(Cl)cc3)cc2)c1 InChI=1S/C30H27ClN4O6/c31-22-6-4-19(5-7-22)18-35-28(37)26(34-27(36)20-12-14-40-15-13-20)17-32-30(35)33-23-8-10-24(11-9-23)41-25-3-1-2-21(16-25)29(38)39/h1-11,16-17,20H,12-15,18H2,(H,32,33)(H,34,36)(H,38,39) SEPAQBAWODPTDE-UHFFFAOYSA-N 196431 US9212130, I-359 P2X purinoceptor 3 Homo sapiens 2 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196431 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196431&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 89634977 318471760 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349308 Cc1nc2ccc(Nc3ncc(NC(=O)C(C)(C)O)c(=O)n3Cc3ccc(Cl)cc3)cc2s1 InChI=1S/C23H22ClN5O3S/c1-13-26-17-9-8-16(10-19(17)33-13)27-22-25-11-18(28-21(31)23(2,3)32)20(30)29(22)12-14-4-6-15(24)7-5-14/h4-11,32H,12H2,1-3H3,(H,25,27)(H,28,31) JSHDWRXELILDKN-UHFFFAOYSA-N 196432 US9212130, I-360 P2X purinoceptor 3 Homo sapiens 3 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196432 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196432&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68017106 318471761 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349309 Cc1nc2ccc(Nc3ncc(NC(=O)C(CO)CO)c(=O)n3Cc3ccc(Cl)cc3)cc2s1 InChI=1S/C23H22ClN5O4S/c1-13-26-18-7-6-17(8-20(18)34-13)27-23-25-9-19(28-21(32)15(11-30)12-31)22(33)29(23)10-14-2-4-16(24)5-3-14/h2-9,15,30-31H,10-12H2,1H3,(H,25,27)(H,28,32) YAMBSFZFOWWFPC-UHFFFAOYSA-N 196433 US9212130, I-361 P2X purinoceptor 3 Homo sapiens 10 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196433 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196433&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68017123 318471762 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349310 Cc1ccc(Oc2ccc(Nc3ncc(NC(=O)C(CO)CO)c(=O)n3Cc3ccc(Cl)cc3)cc2)cn1 InChI=1S/C27H26ClN5O5/c1-17-2-9-23(12-29-17)38-22-10-7-21(8-11-22)31-27-30-13-24(32-25(36)19(15-34)16-35)26(37)33(27)14-18-3-5-20(28)6-4-18/h2-13,19,34-35H,14-16H2,1H3,(H,30,31)(H,32,36) UDXYDKVTYNXTLJ-UHFFFAOYSA-N 196374 BDBM196434::US9212130, I-298 P2X purinoceptor 3 Homo sapiens 7 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196374 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196374&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118579711 318471717 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349311 CC(=O)N1CCC(CC1)C(=O)Nc1cnc(Nc2ccc3nc(C)sc3c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C27H27ClN6O3S/c1-16-30-22-8-7-21(13-24(22)38-16)31-27-29-14-23(26(37)34(27)15-18-3-5-20(28)6-4-18)32-25(36)19-9-11-33(12-10-19)17(2)35/h3-8,13-14,19H,9-12,15H2,1-2H3,(H,29,31)(H,32,36) RXMCLPXWNZFJFG-UHFFFAOYSA-N 196428 BDBM196435::US9212130, I-358 P2X purinoceptor 3 Homo sapiens 18 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196428 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196428&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68017103 318471758 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349131 CC(C)Oc1ccc(Nc2[nH]c(=O)n(C)c(=O)c2Cc2ccc(Cl)cc2)cc1F InChI=1S/C21H21ClFN3O3/c1-12(2)29-18-9-8-15(11-17(18)23)24-19-16(20(27)26(3)21(28)25-19)10-13-4-6-14(22)7-5-13/h4-9,11-12,24H,10H2,1-3H3,(H,25,28) CCXNBDNVJDRULE-UHFFFAOYSA-N 196163 US9212130, I-001 P2X purinoceptor 3 Homo sapiens 901 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196163 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196163&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 77387261 318471584 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349132 CC(C)Oc1ccc(Nc2cc(=O)n(Cc3ccc(Cl)cc3)c(=O)n2Cc2ccc(Cl)cc2)cc1Cl InChI=1S/C27H24Cl3N3O3/c1-17(2)36-24-12-11-22(13-23(24)30)31-25-14-26(34)33(16-19-5-9-21(29)10-6-19)27(35)32(25)15-18-3-7-20(28)8-4-18/h3-14,17,31H,15-16H2,1-2H3 SFNDWMBCHONQMH-UHFFFAOYSA-N 196164 US9212130, I-005 P2X purinoceptor 3 Homo sapiens 238 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196164 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196164&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 77387259 318471585 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349133 COC(=O)C(C)(C)Cn1c(=O)cc(Nc2ccc(OC(C)C)c(Cl)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H29Cl2N3O5/c1-16(2)36-21-11-10-19(12-20(21)28)29-22-13-23(32)31(15-26(3,4)24(33)35-5)25(34)30(22)14-17-6-8-18(27)9-7-17/h6-13,16,29H,14-15H2,1-5H3 UBVNWKCSINJECR-UHFFFAOYSA-N 196165 US9212130, I-010 P2X purinoceptor 3 Homo sapiens 10 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196165 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196165&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 122197887 318471586 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349134 CC(C)Oc1ccc(Nc2cc(=O)n(CC(C)(C)C(O)=O)c(=O)n2Cc2ccc(Cl)cc2)cc1Cl InChI=1S/C25H27Cl2N3O5/c1-15(2)35-20-10-9-18(11-19(20)27)28-21-12-22(31)30(14-25(3,4)23(32)33)24(34)29(21)13-16-5-7-17(26)8-6-16/h5-12,15,28H,13-14H2,1-4H3,(H,32,33) UDRHHHSZLITCJH-UHFFFAOYSA-N 196166 US9212130, I-012 P2X purinoceptor 3 Homo sapiens 6 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196166 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196166&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 122197888 318471587 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349135 CC(C)Oc1ccc(Nc2[nH]c(=O)n(Cc3ccccc3)c(=O)c2Cc2ccc(C)cc2)cc1 InChI=1S/C28H29N3O3/c1-19(2)34-24-15-13-23(14-16-24)29-26-25(17-21-11-9-20(3)10-12-21)27(32)31(28(33)30-26)18-22-7-5-4-6-8-22/h4-16,19,29H,17-18H2,1-3H3,(H,30,33) WBHUFTNKRDUTKV-UHFFFAOYSA-N 196168 US9212130, I-014 P2X purinoceptor 3 Homo sapiens 404 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196168 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196168&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76416924 318471588 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349136 COC(=O)C(C)(C)Cn1c(=O)cc(Nc2ccc(OC(C)C)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H29ClFN3O5/c1-16(2)36-21-11-10-19(12-20(21)28)29-22-13-23(32)31(15-26(3,4)24(33)35-5)25(34)30(22)14-17-6-8-18(27)9-7-17/h6-13,16,29H,14-15H2,1-5H3 HCMWYPAKRJDJFK-UHFFFAOYSA-N 196169 US9212130, I-020 P2X purinoceptor 3 Homo sapiens 28 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196169 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196169&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76416925 318471589 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349137 CC(C)Oc1ccc(Nc2cc(=O)n(CC(C)(C)C(O)=O)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C25H27ClFN3O5/c1-15(2)35-20-10-9-18(11-19(20)27)28-21-12-22(31)30(14-25(3,4)23(32)33)24(34)29(21)13-16-5-7-17(26)8-6-16/h5-12,15,28H,13-14H2,1-4H3,(H,32,33) AIRHRKODYULVSV-UHFFFAOYSA-N 196170 US9212130, I-021 P2X purinoceptor 3 Homo sapiens 19 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196170 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196170&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76416926 318471590 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349138 CC(C)Oc1ccc(Nc2ncc(Cc3ccccc3)c(=O)n2Cc2ccc(Cl)cc2)cc1Cl InChI=1S/C27H25Cl2N3O2/c1-18(2)34-25-13-12-23(15-24(25)29)31-27-30-16-21(14-19-6-4-3-5-7-19)26(33)32(27)17-20-8-10-22(28)11-9-20/h3-13,15-16,18H,14,17H2,1-2H3,(H,30,31) NERSLJAFUQKZFM-UHFFFAOYSA-N 196171 US9212130, I-022 P2X purinoceptor 3 Homo sapiens 147 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196171 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196171&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 56836152 318471591 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349139 CC(C)Oc1ccc(NC2=NC(=O)\C(=C\c3ccccc3)C(=O)N2Cc2ccc(Cl)cc2)cc1Cl InChI=1S/C27H24Cl2N3O3/c1-17(2)35-24-13-12-21(15-23(24)29)30-27-31-25(33)22(14-18-6-4-3-5-7-18)26(34)32(27)16-19-8-10-20(28)11-9-19/h3-13,15,17H,14,16H2,1-2H3,(H,30,31,33) UWEHJAIYCXCVRQ-UHFFFAOYSA-N 196172 US9212130, I-023 P2X purinoceptor 3 Homo sapiens 148 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196172 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196172&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 122362657 318471592 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349140 CCOC(=O)c1cn(Cc2ccccc2)c(=O)cc1Nc1ccc(OC(C)C)c(Cl)c1 InChI=1S/C24H25ClN2O4/c1-4-30-24(29)19-15-27(14-17-8-6-5-7-9-17)23(28)13-21(19)26-18-10-11-22(20(25)12-18)31-16(2)3/h5-13,15-16,26H,4,14H2,1-3H3 LTBWKCKIQBPDIS-UHFFFAOYSA-N 196177 US9212130, I-046 P2X purinoceptor 3 Homo sapiens 395 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196177 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196177&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68017241 318471593 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349141 CCOC(=O)c1cn(Cc2ccccc2)c(Nc2ccc(OC(C)C)c(Cl)c2)cc1=O InChI=1S/C24H25ClN2O4/c1-4-30-24(29)19-15-27(14-17-8-6-5-7-9-17)23(13-21(19)28)26-18-10-11-22(20(25)12-18)31-16(2)3/h5-13,15-16,26H,4,14H2,1-3H3 XAWFGZRPGJEWJK-UHFFFAOYSA-N 196178 US9212130, I-049 P2X purinoceptor 3 Homo sapiens 796 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196178 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196178&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68016945 318471594 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349142 CCOC(=O)c1cn(Cc2ccccc2)c(=O)cc1Nc1ccc(OC(C)C)c(Nc2ccc(OC(C)C)c(Cl)c2)c1 InChI=1S/C33H36ClN3O5/c1-6-40-33(39)26-20-37(19-23-10-8-7-9-11-23)32(38)18-28(26)35-25-13-15-31(42-22(4)5)29(17-25)36-24-12-14-30(27(34)16-24)41-21(2)3/h7-18,20-22,35-36H,6,19H2,1-5H3 KRDZDLBPVHRLFB-UHFFFAOYSA-N 196185 US9212130, I-061 P2X purinoceptor 3 Homo sapiens 748 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196185 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196185&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68016955 318471595 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349143 CC(C)Oc1ccc(Nc2ccc(Cc3nc(oc(=O)c3Cl)N(C)C)cc2)cc1F InChI=1S/C22H23ClFN3O3/c1-13(2)29-19-10-9-16(12-17(19)24)25-15-7-5-14(6-8-15)11-18-20(23)21(28)30-22(26-18)27(3)4/h5-10,12-13,25H,11H2,1-4H3 DQSNKUAFFZYXBT-UHFFFAOYSA-N 196187 US9212130, I-063 P2X purinoceptor 3 Homo sapiens 688 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196187 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196187&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 89771317 318471596 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349144 CC(C)Oc1ccc(Nc2cc(=O)n(Cc3ccccc3)cc2C(=O)c2ccc(Cl)cc2)cc1Cl InChI=1S/C28H24Cl2N2O3/c1-18(2)35-26-13-12-22(14-24(26)30)31-25-15-27(33)32(16-19-6-4-3-5-7-19)17-23(25)28(34)20-8-10-21(29)11-9-20/h3-15,17-18,31H,16H2,1-2H3 UMTVTBGUEAWLPY-UHFFFAOYSA-N 196189 US9212130, I-065 P2X purinoceptor 3 Homo sapiens 128 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196189 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196189&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68016942 318471597 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349145 CC(C)Oc1ccc(Nc2cc(=O)n(Cc3ccccc3)cc2Cc2ccc(Cl)cc2)cc1Cl InChI=1S/C28H26Cl2N2O2/c1-19(2)34-27-13-12-24(15-25(27)30)31-26-16-28(33)32(17-21-6-4-3-5-7-21)18-22(26)14-20-8-10-23(29)11-9-20/h3-13,15-16,18-19,31H,14,17H2,1-2H3 KNUPBPULGWIMID-UHFFFAOYSA-N 196190 US9212130, I-067 P2X purinoceptor 3 Homo sapiens 310 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196190 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196190&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68016947 318471598 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349146 CC(C)Oc1ccc(Nc2cc(=O)n(Cc3ccccc3)cc2C(O)c2ccc(Cl)cc2)cc1Cl InChI=1S/C28H26Cl2N2O3/c1-18(2)35-26-13-12-22(14-24(26)30)31-25-15-27(33)32(16-19-6-4-3-5-7-19)17-23(25)28(34)20-8-10-21(29)11-9-20/h3-15,17-18,28,31,34H,16H2,1-2H3 FZDMDOGNQVRGMD-UHFFFAOYSA-N 196191 US9212130, I-068 P2X purinoceptor 3 Homo sapiens 105 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196191 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196191&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68016948 318471599 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349147 CC(C)Oc1ccc(NC2SC(Oc3ccccc3)=N\C2=C/c2ccc(Cl)cc2)cc1F InChI=1S/C25H22ClFN2O2S/c1-16(2)30-23-13-12-19(15-21(23)27)28-24-22(14-17-8-10-18(26)11-9-17)29-25(32-24)31-20-6-4-3-5-7-20/h3-16,24,28H,1-2H3/b22-14- OQTIRFJXCFMMTL-HMAPJEAMSA-N 196192 US9212130, I-069 P2X purinoceptor 3 Homo sapiens 402 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196192 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196192&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68016944 318471600 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349148 CC(C)Oc1ccc(Nc2oc(Cc3ccccc3)nc2Cc2ccc(Cl)cc2)cc1F InChI=1S/C26H24ClFN2O2/c1-17(2)31-24-13-12-21(16-22(24)28)29-26-23(14-19-8-10-20(27)11-9-19)30-25(32-26)15-18-6-4-3-5-7-18/h3-13,16-17,29H,14-15H2,1-2H3 FZIJDMIOALLJKA-UHFFFAOYSA-N 196193 US9212130, I-070 P2X purinoceptor 3 Homo sapiens 635 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196193 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196193&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 56836018 318471601 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349149 CCNc1ccc(Nc2ccc(OC(C)C)cc2)c(Cc2ccc(Cl)cc2)c1 InChI=1S/C24H27ClN2O/c1-4-26-22-11-14-24(19(16-22)15-18-5-7-20(25)8-6-18)27-21-9-12-23(13-10-21)28-17(2)3/h5-14,16-17,26-27H,4,15H2,1-3H3 WDCMUMISDFNJDI-UHFFFAOYSA-N 196194 US9212130, I-071 P2X purinoceptor 3 Homo sapiens 502 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196194 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196194&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 56836014 318471602 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349150 CCc1cnc(Nc2ccc(OC(C)C)c(F)c2)c(Oc2ccc(C)cc2)n1 InChI=1S/C22H24FN3O2/c1-5-16-13-24-21(22(26-16)28-18-9-6-15(4)7-10-18)25-17-8-11-20(19(23)12-17)27-14(2)3/h6-14H,5H2,1-4H3,(H,24,25) IOLKBHLNOBDENA-UHFFFAOYSA-N 196195 US9212130, I-072 P2X purinoceptor 3 Homo sapiens 749 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196195 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196195&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68017296 318471603 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349151 CC(C)Oc1ccc(Nc2cc(=O)n(CC3COC(C)(C)OC3)c(=O)n2Cc2ccc(Cl)cc2)cc1Cl InChI=1S/C27H31Cl2N3O5/c1-17(2)37-23-10-9-21(11-22(23)29)30-24-12-25(33)32(14-19-15-35-27(3,4)36-16-19)26(34)31(24)13-18-5-7-20(28)8-6-18/h5-12,17,19,30H,13-16H2,1-4H3 DLSHZIRJDCEFBR-UHFFFAOYSA-N 196199 US9212130, I-094 P2X purinoceptor 3 Homo sapiens 5 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196199 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196199&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 77387277 318471604 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349152 COC(=O)[C@@H](C)Cn1c(=O)cc(Nc2ccc(OC(C)C)c(Cl)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H27Cl2N3O5/c1-15(2)35-21-10-9-19(11-20(21)27)28-22-12-23(31)30(13-16(3)24(32)34-4)25(33)29(22)14-17-5-7-18(26)8-6-17/h5-12,15-16,28H,13-14H2,1-4H3/t16-/m0/s1 HUVQXXDHIFQXDI-INIZCTEOSA-N 196200 US9212130, I-095 P2X purinoceptor 3 Homo sapiens 16 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196200 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196200&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 122197889 318471605 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349153 CC(C)Oc1ccc(Nc2nc(=O)c(\C=C\C(O)=O)cn2Cc2ccc(Cl)cc2)cc1Cl InChI=1S/C23H21Cl2N3O4/c1-14(2)32-20-9-8-18(11-19(20)25)26-23-27-22(31)16(5-10-21(29)30)13-28(23)12-15-3-6-17(24)7-4-15/h3-11,13-14H,12H2,1-2H3,(H,29,30)(H,26,27,31)/b10-5+ JXQDOHFLERSFHT-BJMVGYQFSA-N 196201 US9212130, I-097 P2X purinoceptor 3 Homo sapiens 307 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196201 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196201&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68017382 318471606 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349154 CCOC(=O)\C=C\c1cn(Cc2ccc(Cl)cc2)c(Nc2ccc(OC(C)C)c(Cl)c2)nc1=O InChI=1S/C25H25Cl2N3O4/c1-4-33-23(31)12-7-18-15-30(14-17-5-8-19(26)9-6-17)25(29-24(18)32)28-20-10-11-22(21(27)13-20)34-16(2)3/h5-13,15-16H,4,14H2,1-3H3,(H,28,29,32)/b12-7+ PKWQQXSIRJHTMG-KPKJPENVSA-N 196202 US9212130, I-098 P2X purinoceptor 3 Homo sapiens 233 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196202 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196202&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68017410 318471607 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349155 CC(C)Oc1ccc(Nc2cc(=O)n(CC(CO)CO)c(=O)n2Cc2ccc(Cl)cc2)cc1Cl InChI=1S/C24H27Cl2N3O5/c1-15(2)34-21-8-7-19(9-20(21)26)27-22-10-23(32)29(12-17(13-30)14-31)24(33)28(22)11-16-3-5-18(25)6-4-16/h3-10,15,17,27,30-31H,11-14H2,1-2H3 LGKDQLYJDKJISM-UHFFFAOYSA-N 196203 US9212130, I-099 P2X purinoceptor 3 Homo sapiens 6 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196203 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196203&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 77387275 318471608 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349156 CC(C)Oc1ccc(Nc2cc(=O)n(C[C@H](C)C(O)=O)c(=O)n2Cc2ccc(Cl)cc2)cc1Cl InChI=1S/C24H25Cl2N3O5/c1-14(2)34-20-9-8-18(10-19(20)26)27-21-11-22(30)29(12-15(3)23(31)32)24(33)28(21)13-16-4-6-17(25)7-5-16/h4-11,14-15,27H,12-13H2,1-3H3,(H,31,32)/t15-/m0/s1 WYJUFOUPGARUPX-HNNXBMFYSA-N 196204 US9212130, I-100 P2X purinoceptor 3 Homo sapiens 9 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196204 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196204&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 122197890 318471609 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349157 COC(=O)CCCn1c(=O)cc(Nc2ccc(OC(C)C)c(Cl)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H27Cl2N3O5/c1-16(2)35-21-11-10-19(13-20(21)27)28-22-14-23(31)29(12-4-5-24(32)34-3)25(33)30(22)15-17-6-8-18(26)9-7-17/h6-11,13-14,16,28H,4-5,12,15H2,1-3H3 IJSSNGPIOBEDSG-UHFFFAOYSA-N 196205 US9212130, I-103 P2X purinoceptor 3 Homo sapiens 14 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196205 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196205&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 122197891 318471610 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349158 COC(=O)Cn1c(=O)cc(Nc2ccc(OC(C)C)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H23ClFN3O5/c1-14(2)33-19-9-8-17(10-18(19)25)26-20-11-21(29)28(13-22(30)32-3)23(31)27(20)12-15-4-6-16(24)7-5-15/h4-11,14,26H,12-13H2,1-3H3 VXCLKDJVSMOYIR-UHFFFAOYSA-N 196206 US9212130, I-104 P2X purinoceptor 3 Homo sapiens 96 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196206 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196206&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 77387253 318471611 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349159 CC(C)Oc1ccc(Nc2cc(=O)n(CC(O)=O)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C22H21ClFN3O5/c1-13(2)32-18-8-7-16(9-17(18)24)25-19-10-20(28)27(12-21(29)30)22(31)26(19)11-14-3-5-15(23)6-4-14/h3-10,13,25H,11-12H2,1-2H3,(H,29,30) ADPDYZYWVZWHLV-UHFFFAOYSA-N 196207 US9212130, I-105 P2X purinoceptor 3 Homo sapiens 412 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196207 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196207&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 77387279 318471612 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349160 CC(C)Oc1ccc(Nc2cc(=O)n(CCCC(O)=O)c(=O)n2Cc2ccc(Cl)cc2)cc1Cl InChI=1S/C24H25Cl2N3O5/c1-15(2)34-20-10-9-18(12-19(20)26)27-21-13-22(30)28(11-3-4-23(31)32)24(33)29(21)14-16-5-7-17(25)8-6-16/h5-10,12-13,15,27H,3-4,11,14H2,1-2H3,(H,31,32) QIJQSCRAGIBWKA-UHFFFAOYSA-N 196208 US9212130, I-106 P2X purinoceptor 3 Homo sapiens 34 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196208 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196208&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 77387247 318471613 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349161 COC(=O)C(C)(C)Cn1c(=O)cc(Nc2cccc(c2)C(F)(F)F)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H23ClF3N3O4/c1-23(2,21(33)35-3)14-31-20(32)12-19(29-18-6-4-5-16(11-18)24(26,27)28)30(22(31)34)13-15-7-9-17(25)10-8-15/h4-12,29H,13-14H2,1-3H3 QTWXAVBBCCUZJH-UHFFFAOYSA-N 196209 US9212130, I-107 P2X purinoceptor 3 Homo sapiens 51 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196209 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196209&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 122197892 318471614 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349162 COC(=O)C(C)(C)Cn1c(=O)cc(Nc2cccc(n2)C(F)(F)F)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H22ClF3N4O4/c1-22(2,20(33)35-3)13-31-19(32)11-18(29-17-6-4-5-16(28-17)23(25,26)27)30(21(31)34)12-14-7-9-15(24)10-8-14/h4-11H,12-13H2,1-3H3,(H,28,29) SNRADYNYKKMZLZ-UHFFFAOYSA-N 196210 US9212130, I-108 P2X purinoceptor 3 Homo sapiens 61 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196210 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196210&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 122197893 318471615 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349163 CC(C)Oc1ccc(Nc2nc(OCCO)c3ccccc3c2C(=O)c2ccc(Cl)cc2)cc1F InChI=1S/C27H24ClFN2O4/c1-16(2)35-23-12-11-19(15-22(23)29)30-26-24(25(33)17-7-9-18(28)10-8-17)20-5-3-4-6-21(20)27(31-26)34-14-13-32/h3-12,15-16,32H,13-14H2,1-2H3,(H,30,31) KQMRTDWCNSEZFD-UHFFFAOYSA-N 196212 US9212130, I-110 P2X purinoceptor 3 Homo sapiens 405 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196212 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196212&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68016915 318471616 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349164 CC(C)Oc1ccc(NC2=CC(O)N(CC(=O)NC(CO)CO)C(=O)N2Cc2ccc(Cl)cc2)cc1F InChI=1S/C25H30ClFN4O6/c1-15(2)37-21-8-7-18(9-20(21)27)28-22-10-24(35)31(12-23(34)29-19(13-32)14-33)25(36)30(22)11-16-3-5-17(26)6-4-16/h3-10,15,19,24,28,32-33,35H,11-14H2,1-2H3,(H,29,34) SXUHAKLDTAIIIC-UHFFFAOYSA-N 196213 US9212130, I-111 P2X purinoceptor 3 Homo sapiens 11 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196213 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196213&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118579713 318471617 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349165 CC(C)Oc1ccc(NC2=CC(O)N(CC(=O)NCCO)C(=O)N2Cc2ccc(Cl)cc2)cc1F InChI=1S/C24H28ClFN4O5/c1-15(2)35-20-8-7-18(11-19(20)26)28-21-12-23(33)30(14-22(32)27-9-10-31)24(34)29(21)13-16-3-5-17(25)6-4-16/h3-8,11-12,15,23,28,31,33H,9-10,13-14H2,1-2H3,(H,27,32) KRDNVSPAJVFRND-UHFFFAOYSA-N 196214 US9212130, I-112 P2X purinoceptor 3 Homo sapiens 14 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196214 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196214&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118579698 318471618 C04080 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349166 CC(C)(CN1C(O)C=C(Nc2cccc(c2)C(F)(F)F)N(Cc2ccc(Cl)cc2)C1=O)C(O)=O InChI=1S/C23H23ClF3N3O4/c1-22(2,20(32)33)13-30-19(31)11-18(28-17-5-3-4-15(10-17)23(25,26)27)29(21(30)34)12-14-6-8-16(24)9-7-14/h3-11,19,28,31H,12-13H2,1-2H3,(H,32,33) DQAKUNBTVJPUFG-UHFFFAOYSA-N 196215 US9212130, I-113 P2X purinoceptor 3 Homo sapiens 72 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196215 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196215&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 89771321 318471619 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349167 CC(C)(CN1C(O)C=C(Nc2cccc(n2)C(F)(F)F)N(Cc2ccc(Cl)cc2)C1=O)C(O)=O InChI=1S/C22H22ClF3N4O4/c1-21(2,19(32)33)12-30-18(31)10-17(28-16-5-3-4-15(27-16)22(24,25)26)29(20(30)34)11-13-6-8-14(23)9-7-13/h3-10,18,31H,11-12H2,1-2H3,(H,27,28)(H,32,33) WPEJNWNXLLGQQP-UHFFFAOYSA-N 196216 US9212130, I-114 P2X purinoceptor 3 Homo sapiens 160 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196216 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196216&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 89771322 318471620 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349168 CCOC(=O)CCC1=CN(Cc2ccc(Cl)cc2)C(Nc2ccc(OC(C)C)c(Cl)c2)=NC1O InChI=1S/C25H29Cl2N3O4/c1-4-33-23(31)12-7-18-15-30(14-17-5-8-19(26)9-6-17)25(29-24(18)32)28-20-10-11-22(21(27)13-20)34-16(2)3/h5-6,8-11,13,15-16,24,32H,4,7,12,14H2,1-3H3,(H,28,29) QJACLZCILGHZEA-UHFFFAOYSA-N 196217 US9212130, I-115 P2X purinoceptor 3 Homo sapiens 51 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196217 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196217&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 89771323 318471621 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349169 CCOC(=O)CCC1CN(Cc2ccc(Cl)cc2)C(Nc2ccc(OC(C)C)c(Cl)c2)=NC1=O InChI=1S/C25H29Cl2N3O4/c1-4-33-23(31)12-7-18-15-30(14-17-5-8-19(26)9-6-17)25(29-24(18)32)28-20-10-11-22(21(27)13-20)34-16(2)3/h5-6,8-11,13,16,18H,4,7,12,14-15H2,1-3H3,(H,28,29,32) VSKCTZSZIYVTGB-UHFFFAOYSA-N 196218 US9212130, I-116 P2X purinoceptor 3 Homo sapiens 315 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196218 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196218&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68016929 318471622 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349170 CC(C)Oc1ccc(Nc2nc(=O)c(CCC(O)=O)cn2Cc2ccc(Cl)cc2)cc1Cl InChI=1S/C23H23Cl2N3O4/c1-14(2)32-20-9-8-18(11-19(20)25)26-23-27-22(31)16(5-10-21(29)30)13-28(23)12-15-3-6-17(24)7-4-15/h3-4,6-9,11,13-14H,5,10,12H2,1-2H3,(H,29,30)(H,26,27,31) BINDSFXMXHITKV-UHFFFAOYSA-N 196219 US9212130, I-117 P2X purinoceptor 3 Homo sapiens 152 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196219 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196219&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68016926 318471623 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349171 CCOC(=O)c1cn(Cc2ccc(Cl)cc2)c(Nc2ccc(OC(C)C)c(Cl)c2)nc1=O InChI=1S/C23H23Cl2N3O4/c1-4-31-22(30)18-13-28(12-15-5-7-16(24)8-6-15)23(27-21(18)29)26-17-9-10-20(19(25)11-17)32-14(2)3/h5-11,13-14H,4,12H2,1-3H3,(H,26,27,29) SNKBKOSOKNMPEM-UHFFFAOYSA-N 196224 US9212130, I-125 P2X purinoceptor 3 Homo sapiens 243 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196224 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196224&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 89771326 318471624 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349172 CCOC(=O)c1cnc(Nc2ccc(OC(C)C)c(Cl)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H23Cl2N3O4/c1-4-31-22(30)18-12-26-23(27-17-9-10-20(19(25)11-17)32-14(2)3)28(21(18)29)13-15-5-7-16(24)8-6-15/h5-12,14H,4,13H2,1-3H3,(H,26,27) AKVGANBPEPZVTO-UHFFFAOYSA-N 196225 US9212130, I-126 P2X purinoceptor 3 Homo sapiens 50 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196225 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196225&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 89771327 318471625 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349173 CC(C)Oc1ccc(Nc2ncc(C(O)=O)c(=O)n2Cc2ccc(Cl)cc2)cc1Cl InChI=1S/C21H19Cl2N3O4/c1-12(2)30-18-8-7-15(9-17(18)23)25-21-24-10-16(20(28)29)19(27)26(21)11-13-3-5-14(22)6-4-13/h3-10,12H,11H2,1-2H3,(H,24,25)(H,28,29) HRYWEYSNYUGMRO-UHFFFAOYSA-N 196227 US9212130, I-129 P2X purinoceptor 3 Homo sapiens 490 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196227 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196227&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 89771329 318471626 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349174 CCOC(=O)c1cn(Cc2ccc(Cl)cc2)c(Nc2ccc(OC(C)C)c(F)c2)nc1=O InChI=1S/C23H23ClFN3O4/c1-4-31-22(30)18-13-28(12-15-5-7-16(24)8-6-15)23(27-21(18)29)26-17-9-10-20(19(25)11-17)32-14(2)3/h5-11,13-14H,4,12H2,1-3H3,(H,26,27,29) BTFYMINAMPTEPW-UHFFFAOYSA-N 196228 US9212130, I-131 P2X purinoceptor 3 Homo sapiens 108 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196228 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196228&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68017254 318471627 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349175 CCOC(=O)\C=C\c1cnc(Nc2ccc(OC(C)C)c(Cl)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H25Cl2N3O4/c1-4-33-23(31)12-7-18-14-28-25(29-20-10-11-22(21(27)13-20)34-16(2)3)30(24(18)32)15-17-5-8-19(26)9-6-17/h5-14,16H,4,15H2,1-3H3,(H,28,29)/b12-7+ IAIRCJXMSWPKDT-KPKJPENVSA-N 196229 US9212130, I-132 P2X purinoceptor 3 Homo sapiens 206 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196229 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196229&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68017261 318471628 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349176 CCOC(=O)c1cnc(Nc2ccc(OC(C)C)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H23ClFN3O4/c1-4-31-22(30)18-12-26-23(27-17-9-10-20(19(25)11-17)32-14(2)3)28(21(18)29)13-15-5-7-16(24)8-6-15/h5-12,14H,4,13H2,1-3H3,(H,26,27) LCJYPLNAQPKCFW-UHFFFAOYSA-N 196230 US9212130, I-133 P2X purinoceptor 3 Homo sapiens 71 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196230 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196230&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68017255 318471629 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349177 CC(C)Oc1ccc(Nc2ncc(CCC(O)=O)c(=O)n2Cc2ccc(Cl)cc2)cc1Cl InChI=1S/C23H23Cl2N3O4/c1-14(2)32-20-9-8-18(11-19(20)25)27-23-26-12-16(5-10-21(29)30)22(31)28(23)13-15-3-6-17(24)7-4-15/h3-4,6-9,11-12,14H,5,10,13H2,1-2H3,(H,26,27)(H,29,30) PRIXAUSQDACAQD-UHFFFAOYSA-N 196233 US9212130, I-137 P2X purinoceptor 3 Homo sapiens 219 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196233 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196233&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68016961 318471630 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349178 CC(C)Oc1ccc(Nc2ncc(N3CCOCC3)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C24H26ClFN4O3/c1-16(2)33-22-8-7-19(13-20(22)26)28-24-27-14-21(29-9-11-32-12-10-29)23(31)30(24)15-17-3-5-18(25)6-4-17/h3-8,13-14,16H,9-12,15H2,1-2H3,(H,27,28) RHKXPSRPLJATML-UHFFFAOYSA-N 196234 US9212130, I-138 P2X purinoceptor 3 Homo sapiens 201 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196234 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196234&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68016958 318471631 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349179 CC(C)Oc1ccc(Nc2ncc(\C=C\C(O)=O)c(=O)n2Cc2ccc(Cl)cc2)cc1Cl InChI=1S/C23H21Cl2N3O4/c1-14(2)32-20-9-8-18(11-19(20)25)27-23-26-12-16(5-10-21(29)30)22(31)28(23)13-15-3-6-17(24)7-4-15/h3-12,14H,13H2,1-2H3,(H,26,27)(H,29,30)/b10-5+ NUCWLSORIUXICQ-BJMVGYQFSA-N 196235 US9212130, I-139 P2X purinoceptor 3 Homo sapiens 331 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196235 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196235&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68016959 318471632 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349180 CC(C)Oc1ccc(Nc2nc(=O)c(cn2Cc2ccc(Cl)cc2)C(=O)NCCO)cc1F InChI=1S/C23H24ClFN4O4/c1-14(2)33-20-8-7-17(11-19(20)25)27-23-28-22(32)18(21(31)26-9-10-30)13-29(23)12-15-3-5-16(24)6-4-15/h3-8,11,13-14,30H,9-10,12H2,1-2H3,(H,26,31)(H,27,28,32) HCMRQOGIIUYKPA-UHFFFAOYSA-N 196239 US9212130, I-146 P2X purinoceptor 3 Homo sapiens 383 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196239 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196239&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68017313 318471633 C04080 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349181 CCOC(=O)c1cn(Cc2ccc(Cl)cc2)c2cc(Nc3ccccc3)ccc2c1=O InChI=1S/C25H21ClN2O3/c1-2-31-25(30)22-16-28(15-17-8-10-18(26)11-9-17)23-14-20(12-13-21(23)24(22)29)27-19-6-4-3-5-7-19/h3-14,16,27H,2,15H2,1H3 IYRVLLAVVYWVIB-UHFFFAOYSA-N 196241 US9212130, I-148 P2X purinoceptor 3 Homo sapiens 324 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196241 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196241&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68017067 318471634 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349182 CC(C)Oc1ccc(Nc2nc(=O)c(cn2Cc2ccc(Cl)cc2)C(=O)NC(CO)CO)cc1F InChI=1S/C24H26ClFN4O5/c1-14(2)35-21-8-7-17(9-20(21)26)28-24-29-23(34)19(22(33)27-18(12-31)13-32)11-30(24)10-15-3-5-16(25)6-4-15/h3-9,11,14,18,31-32H,10,12-13H2,1-2H3,(H,27,33)(H,28,29,34) FVLLUEJFFCVMOB-UHFFFAOYSA-N 196243 US9212130, I-150 P2X purinoceptor 3 Homo sapiens 120 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196243 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196243&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68017070 318471635 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349183 CC(C)Oc1ccc(Nc2ncc(C(=O)NCCO)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C23H24ClFN4O4/c1-14(2)33-20-8-7-17(11-19(20)25)28-23-27-12-18(21(31)26-9-10-30)22(32)29(23)13-15-3-5-16(24)6-4-15/h3-8,11-12,14,30H,9-10,13H2,1-2H3,(H,26,31)(H,27,28) VRLLUQAVUUASDA-UHFFFAOYSA-N 196245 US9212130, I-152 P2X purinoceptor 3 Homo sapiens 96 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196245 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196245&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68017053 318471636 C04080 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349184 CC(C)Oc1ccc(Nc2ncc(C(=O)NC(CO)CO)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C24H26ClFN4O5/c1-14(2)35-21-8-7-17(9-20(21)26)29-24-27-10-19(22(33)28-18(12-31)13-32)23(34)30(24)11-15-3-5-16(25)6-4-15/h3-10,14,18,31-32H,11-13H2,1-2H3,(H,27,29)(H,28,33) QEFYWILQNHKGRP-UHFFFAOYSA-N 196246 US9212130, I-153 P2X purinoceptor 3 Homo sapiens 59 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196246 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196246&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68017054 318471637 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349185 CC(C)Oc1ccc(Nc2ncc(C(=O)N(C)CCO)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C24H26ClFN4O4/c1-15(2)34-21-9-8-18(12-20(21)26)28-24-27-13-19(22(32)29(3)10-11-31)23(33)30(24)14-16-4-6-17(25)7-5-16/h4-9,12-13,15,31H,10-11,14H2,1-3H3,(H,27,28) PUCFEFHEUCGUMT-UHFFFAOYSA-N 196249 US9212130, I-156 P2X purinoceptor 3 Homo sapiens 509 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196249 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196249&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68017306 318471638 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349186 CCOC(=O)\C=C\c1cnc(Nc2ccc(OC(C)C)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H25ClFN3O4/c1-4-33-23(31)12-7-18-14-28-25(29-20-10-11-22(21(27)13-20)34-16(2)3)30(24(18)32)15-17-5-8-19(26)9-6-17/h5-14,16H,4,15H2,1-3H3,(H,28,29)/b12-7+ KFDDCCABKASZOH-KPKJPENVSA-N 196250 US9212130, I-157 P2X purinoceptor 3 Homo sapiens 589 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196250 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196250&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68017311 318471639 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349187 CC(C)Oc1ccc(Nc2ncc(NC(=O)OC(C)(C)C)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C25H28ClFN4O4/c1-15(2)34-21-11-10-18(12-19(21)27)29-23-28-13-20(30-24(33)35-25(3,4)5)22(32)31(23)14-16-6-8-17(26)9-7-16/h6-13,15H,14H2,1-5H3,(H,28,29)(H,30,33) GTBUVLCEFNIYMW-UHFFFAOYSA-N 196251 US9212130, I-158 P2X purinoceptor 3 Homo sapiens 20 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196251 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196251&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68017304 318471640 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349188 COC(=O)[C@H](C)NC(=O)c1cnc(Nc2ccc(OC(C)C)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H26ClFN4O5/c1-14(2)36-21-10-9-18(11-20(21)27)30-25-28-12-19(22(32)29-15(3)24(34)35-4)23(33)31(25)13-16-5-7-17(26)8-6-16/h5-12,14-15H,13H2,1-4H3,(H,28,30)(H,29,32)/t15-/m0/s1 XFMVUAIKWNDPKG-HNNXBMFYSA-N 196257 US9212130, I-164 P2X purinoceptor 3 Homo sapiens 18 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196257 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196257&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 89771331 318471641 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349189 CNc1ncc(Nc2cccc(c2)C(F)(F)F)c(Cc2ccc(Cl)cc2)n1 InChI=1S/C19H16ClF3N4/c1-24-18-25-11-17(16(27-18)9-12-5-7-14(20)8-6-12)26-15-4-2-3-13(10-15)19(21,22)23/h2-8,10-11,26H,9H2,1H3,(H,24,25,27) JVBGZSCCFYPMOK-UHFFFAOYSA-N 196283 US9212130, I-190 P2X purinoceptor 3 Homo sapiens 990 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196283 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196283&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68017433 318471642 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349190 COC(=O)[C@@H](C)NC(=O)c1cnc(Nc2ccc(OC(C)C)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H26ClFN4O5/c1-14(2)36-21-10-9-18(11-20(21)27)30-25-28-12-19(22(32)29-15(3)24(34)35-4)23(33)31(25)13-16-5-7-17(26)8-6-16/h5-12,14-15H,13H2,1-4H3,(H,28,30)(H,29,32)/t15-/m1/s1 XFMVUAIKWNDPKG-OAHLLOKOSA-N 196290 US9212130, I-197 P2X purinoceptor 3 Homo sapiens 98 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196290 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196290&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 89771340 318471643 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349191 CC(C)Oc1ccc(Nc2ncc(C(=O)N[C@@H](C)C(O)=O)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C24H24ClFN4O5/c1-13(2)35-20-9-8-17(10-19(20)26)29-24-27-11-18(21(31)28-14(3)23(33)34)22(32)30(24)12-15-4-6-16(25)7-5-15/h4-11,13-14H,12H2,1-3H3,(H,27,29)(H,28,31)(H,33,34)/t14-/m0/s1 SFVGYHGFIZQZQV-AWEZNQCLSA-N 196293 US9212130, I-201 P2X purinoceptor 3 Homo sapiens 229 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196293 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196293&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 89771341 318471644 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349192 CC(C)Oc1ccc(Nc2ncc(N(C)C(=O)OC(C)(C)C)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C26H30ClFN4O4/c1-16(2)35-22-12-11-19(13-20(22)28)30-24-29-14-21(31(6)25(34)36-26(3,4)5)23(33)32(24)15-17-7-9-18(27)10-8-17/h7-14,16H,15H2,1-6H3,(H,29,30) KNBXDOVGQNKICQ-UHFFFAOYSA-N 196294 US9212130, I-208 P2X purinoceptor 3 Homo sapiens 50 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196294 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196294&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68017098 318471645 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349193 CC(C)Oc1ccc(Nc2nc(=O)c(cn2Cc2ccc(Cl)cc2)N2CCOCC2)cc1F InChI=1S/C24H26ClFN4O3/c1-16(2)33-22-8-7-19(13-20(22)26)27-24-28-23(31)21(29-9-11-32-12-10-29)15-30(24)14-17-3-5-18(25)6-4-17/h3-8,13,15-16H,9-12,14H2,1-2H3,(H,27,28,31) MZFUPTIDCXAEQV-UHFFFAOYSA-N 196295 US9212130, I-209 P2X purinoceptor 3 Homo sapiens 397 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196295 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196295&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68017102 318471646 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349194 COC(=O)[C@@H](C)Cn1c(=O)cc(Nc2ccc(OC(C)C)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H30ClN3O5/c1-16(2)35-22-11-10-21(12-17(22)3)28-23-13-24(31)30(14-18(4)25(32)34-5)26(33)29(23)15-19-6-8-20(27)9-7-19/h6-13,16,18,28H,14-15H2,1-5H3/t18-/m0/s1 KACWNNXOYRQDQC-SFHVURJKSA-N 196298 US9212130, I-212 P2X purinoceptor 3 Homo sapiens 37 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196298 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196298&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 122197894 318471647 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349195 COC(=O)[C@@H](C)Cn1c(=O)cc(Nc2ccc(OC(C)C)cn2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H27ClN4O5/c1-15(2)34-19-9-10-20(26-12-19)27-21-11-22(30)29(13-16(3)23(31)33-4)24(32)28(21)14-17-5-7-18(25)8-6-17/h5-12,15-16H,13-14H2,1-4H3,(H,26,27)/t16-/m0/s1 FPPXRDZKTSQYBF-INIZCTEOSA-N 196299 US9212130, I-213 P2X purinoceptor 3 Homo sapiens 427 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196299 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196299&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 122197895 318471648 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349196 CC(C)Oc1ccc(Nc2cc(=O)n(C[C@H](C)C(O)=O)c(=O)n2Cc2ccc(Cl)cc2)cc1C InChI=1S/C25H28ClN3O5/c1-15(2)34-21-10-9-20(11-16(21)3)27-22-12-23(30)29(13-17(4)24(31)32)25(33)28(22)14-18-5-7-19(26)8-6-18/h5-12,15,17,27H,13-14H2,1-4H3,(H,31,32)/t17-/m0/s1 RPVJHFQMYYKECB-KRWDZBQOSA-N 196300 US9212130, I-215 P2X purinoceptor 3 Homo sapiens 24 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196300 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196300&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 122197896 318471649 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349197 COC(=O)[C@@H](C)Cn1c(=O)cc(Nc2ccc(OC(C)C)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H28ClN3O5/c1-16(2)34-21-11-9-20(10-12-21)27-22-13-23(30)29(14-17(3)24(31)33-4)25(32)28(22)15-18-5-7-19(26)8-6-18/h5-13,16-17,27H,14-15H2,1-4H3/t17-/m0/s1 QEUWISIWCGYFBE-KRWDZBQOSA-N 196301 US9212130, I-216 P2X purinoceptor 3 Homo sapiens 105 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196301 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196301&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 122197897 318471650 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349198 CC(C)Oc1ccc(Nc2cc(=O)n(C[C@H](C)C(O)=O)c(=O)n2Cc2ccc(Cl)cc2)nc1 InChI=1S/C23H25ClN4O5/c1-14(2)33-18-8-9-19(25-11-18)26-20-10-21(29)28(12-15(3)22(30)31)23(32)27(20)13-16-4-6-17(24)7-5-16/h4-11,14-15H,12-13H2,1-3H3,(H,25,26)(H,30,31)/t15-/m0/s1 KLDNEVAINXHNRD-HNNXBMFYSA-N 196302 US9212130, I-217 P2X purinoceptor 3 Homo sapiens 453 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196302 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196302&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 122197898 318471651 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349199 CC(C)Oc1ccc(Nc2cc(=O)n(C[C@H](C)C(O)=O)c(=O)n2Cc2ccc(Cl)cc2)cc1 InChI=1S/C24H26ClN3O5/c1-15(2)33-20-10-8-19(9-11-20)26-21-12-22(29)28(13-16(3)23(30)31)24(32)27(21)14-17-4-6-18(25)7-5-17/h4-12,15-16,26H,13-14H2,1-3H3,(H,30,31)/t16-/m0/s1 SIUDUNDIKUUPOZ-INIZCTEOSA-N 196303 US9212130, I-218 P2X purinoceptor 3 Homo sapiens 55 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196303 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196303&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 122197899 318471652 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349200 CNc1cnc(Nc2ccc(OC(C)C)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C21H22ClFN4O2/c1-13(2)29-19-9-8-16(10-17(19)23)26-21-25-11-18(24-3)20(28)27(21)12-14-4-6-15(22)7-5-14/h4-11,13,24H,12H2,1-3H3,(H,25,26) ZRFUUKXZQLSYNO-UHFFFAOYSA-N 196305 US9212130, I-222 P2X purinoceptor 3 Homo sapiens 560 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196305 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196305&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68017389 318471653 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349201 CC(C)Oc1ccc(Nc2ncc(NCCCO)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C23H26ClFN4O3/c1-15(2)32-21-9-8-18(12-19(21)25)28-23-27-13-20(26-10-3-11-30)22(31)29(23)14-16-4-6-17(24)7-5-16/h4-9,12-13,15,26,30H,3,10-11,14H2,1-2H3,(H,27,28) WCFYOABKWMKPHV-UHFFFAOYSA-N 196306 US9212130, I-223 P2X purinoceptor 3 Homo sapiens 724 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196306 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196306&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68017390 318471654 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349202 CC(C)Oc1ccc(Nc2ncc(NCC3CCOCC3)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C26H30ClFN4O3/c1-17(2)35-24-8-7-21(13-22(24)28)31-26-30-15-23(29-14-18-9-11-34-12-10-18)25(33)32(26)16-19-3-5-20(27)6-4-19/h3-8,13,15,17-18,29H,9-12,14,16H2,1-2H3,(H,30,31) NVWWGXVTCOMGCZ-UHFFFAOYSA-N 196307 US9212130, I-224 P2X purinoceptor 3 Homo sapiens 511 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196307 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196307&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68017391 318471655 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349203 CC(C)Oc1ccc(Nc2nc(=O)c3cc(ccc3n2Cc2ccc(Cl)cc2)C(F)(F)F)cc1Cl InChI=1S/C25H20Cl2F3N3O2/c1-14(2)35-22-10-8-18(12-20(22)27)31-24-32-23(34)19-11-16(25(28,29)30)5-9-21(19)33(24)13-15-3-6-17(26)7-4-15/h3-12,14H,13H2,1-2H3,(H,31,32,34) HMGUDWVQXPKOKJ-UHFFFAOYSA-N 196308 US9212130, I-227 P2X purinoceptor 3 Homo sapiens 974 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196308 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196308&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68017392 318471656 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349204 CC(C)Oc1ccc(Nc2nc(=O)c(NC(=O)OC(C)(C)C)cn2Cc2ccc(Cl)cc2)cc1F InChI=1S/C25H28ClFN4O4/c1-15(2)34-21-11-10-18(12-19(21)27)28-23-30-22(32)20(29-24(33)35-25(3,4)5)14-31(23)13-16-6-8-17(26)9-7-16/h6-12,14-15H,13H2,1-5H3,(H,29,33)(H,28,30,32) IGUNAVHNROPIKV-UHFFFAOYSA-N 196310 US9212130, I-230 P2X purinoceptor 3 Homo sapiens 92 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196310 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196310&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68017386 318471657 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349205 CC(C)Oc1ccc(Nc2ncc(NC(=O)CCC(O)=O)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C24H24ClFN4O5/c1-14(2)35-20-8-7-17(11-18(20)26)28-24-27-12-19(29-21(31)9-10-22(32)33)23(34)30(24)13-15-3-5-16(25)6-4-15/h3-8,11-12,14H,9-10,13H2,1-2H3,(H,27,28)(H,29,31)(H,32,33) CHAFTIDXGOEHBW-UHFFFAOYSA-N 196311 US9212130, I-231 P2X purinoceptor 3 Homo sapiens 226 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196311 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196311&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68017411 318471658 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349206 CC(C)Oc1ccc(Nc2ncc(CCC(O)=O)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C23H23ClFN3O4/c1-14(2)32-20-9-8-18(11-19(20)25)27-23-26-12-16(5-10-21(29)30)22(31)28(23)13-15-3-6-17(24)7-4-15/h3-4,6-9,11-12,14H,5,10,13H2,1-2H3,(H,26,27)(H,29,30) NXNDYTOMSIYBSC-UHFFFAOYSA-N 196312 US9212130, I-232 P2X purinoceptor 3 Homo sapiens 681 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196312 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196312&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68017402 318471659 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349207 CC(C)Oc1ccc(Nc2ncc(NC(=O)CC3CCOCC3)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C27H30ClFN4O4/c1-17(2)37-24-8-7-21(14-22(24)29)31-27-30-15-23(32-25(34)13-18-9-11-36-12-10-18)26(35)33(27)16-19-3-5-20(28)6-4-19/h3-8,14-15,17-18H,9-13,16H2,1-2H3,(H,30,31)(H,32,34) ITKORKRRNUOHLX-UHFFFAOYSA-N 196313 US9212130, I-233 P2X purinoceptor 3 Homo sapiens 49 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196313 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196313&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68017319 318471660 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349208 CC(C)Oc1ccc(Nc2ncc(NC(=O)C3CCOCC3)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C26H28ClFN4O4/c1-16(2)36-23-8-7-20(13-21(23)28)30-26-29-14-22(31-24(33)18-9-11-35-12-10-18)25(34)32(26)15-17-3-5-19(27)6-4-17/h3-8,13-14,16,18H,9-12,15H2,1-2H3,(H,29,30)(H,31,33) DRELVYVZJNAYPN-UHFFFAOYSA-N 196314 US9212130, I-234 P2X purinoceptor 3 Homo sapiens 4 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196314 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196314&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68017320 318471661 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349209 CC(C)Oc1ccc(Nc2ncc(NC(=O)C3CCOCC3)c(=O)n2Cc2ccc(Cl)cc2)cc1 InChI=1S/C26H29ClN4O4/c1-17(2)35-22-9-7-21(8-10-22)29-26-28-15-23(30-24(32)19-11-13-34-14-12-19)25(33)31(26)16-18-3-5-20(27)6-4-18/h3-10,15,17,19H,11-14,16H2,1-2H3,(H,28,29)(H,30,32) YPNQOSUUCNSSPA-UHFFFAOYSA-N 196315 US9212130, I-235 P2X purinoceptor 3 Homo sapiens 11 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196315 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196315&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68017327 318471662 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349210 CC(C)Oc1ccc(Nc2ncc(NC(=O)C3CCOCC3)c(=O)n2Cc2ccc(Cl)cc2)cc1Cl InChI=1S/C26H28Cl2N4O4/c1-16(2)36-23-8-7-20(13-21(23)28)30-26-29-14-22(31-24(33)18-9-11-35-12-10-18)25(34)32(26)15-17-3-5-19(27)6-4-17/h3-8,13-14,16,18H,9-12,15H2,1-2H3,(H,29,30)(H,31,33) HCXCTBUQSPWVBS-UHFFFAOYSA-N 196316 US9212130, I-236 P2X purinoceptor 3 Homo sapiens 6 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196316 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196316&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 89634802 318471663 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349211 CC(C)Oc1ccc(Nc2ncc(NC(=O)C3CCOCC3)c(=O)n2Cc2ccc(Cl)cc2)cc1C InChI=1S/C27H31ClN4O4/c1-17(2)36-24-9-8-22(14-18(24)3)30-27-29-15-23(31-25(33)20-10-12-35-13-11-20)26(34)32(27)16-19-4-6-21(28)7-5-19/h4-9,14-15,17,20H,10-13,16H2,1-3H3,(H,29,30)(H,31,33) KOAKCQPGWKMGTB-UHFFFAOYSA-N 196317 US9212130, I-237 P2X purinoceptor 3 Homo sapiens 13 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196317 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196317&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118579699 318471664 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349212 CC(C)Oc1ccc(Nc2nc(=O)c(NC(=O)C3CCOCC3)cn2Cc2ccc(Cl)cc2)cc1F InChI=1S/C26H28ClFN4O4/c1-16(2)36-23-8-7-20(13-21(23)28)29-26-31-25(34)22(30-24(33)18-9-11-35-12-10-18)15-32(26)14-17-3-5-19(27)6-4-17/h3-8,13,15-16,18H,9-12,14H2,1-2H3,(H,30,33)(H,29,31,34) AICTWAYRXQXKGN-UHFFFAOYSA-N 196318 US9212130, I-238 P2X purinoceptor 3 Homo sapiens 653 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196318 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196318&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68017440 318471665 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349213 CC(C)Oc1ccc(Nc2nc(=O)c(NC=O)cn2Cc2ccc(Cl)cc2)cc1F InChI=1S/C21H20ClFN4O3/c1-13(2)30-19-8-7-16(9-17(19)23)25-21-26-20(29)18(24-12-28)11-27(21)10-14-3-5-15(22)6-4-14/h3-9,11-13H,10H2,1-2H3,(H,24,28)(H,25,26,29) VDNKEASTBVDTKQ-UHFFFAOYSA-N 196319 US9212130, I-239 P2X purinoceptor 3 Homo sapiens 515 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196319 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196319&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 88557277 318471666 C06049 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349214 COCCC(=O)Nc1cn(Cc2ccc(Cl)cc2)c(Nc2ccc(OC(C)C)c(F)c2)nc1=O InChI=1S/C24H26ClFN4O4/c1-15(2)34-21-9-8-18(12-19(21)26)27-24-29-23(32)20(28-22(31)10-11-33-3)14-30(24)13-16-4-6-17(25)7-5-16/h4-9,12,14-15H,10-11,13H2,1-3H3,(H,28,31)(H,27,29,32) XLFOXZYUAFCMCR-UHFFFAOYSA-N 196320 US9212130, I-240 P2X purinoceptor 3 Homo sapiens 417 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196320 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196320&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118579708 318471667 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349215 CC(C)Oc1ccc(Nc2nc(=O)c(cn2Cc2ccc(Cl)cc2)C(=O)NC2CCOCC2)cc1F InChI=1S/C26H28ClFN4O4/c1-16(2)36-23-8-7-20(13-22(23)28)30-26-31-25(34)21(24(33)29-19-9-11-35-12-10-19)15-32(26)14-17-3-5-18(27)6-4-17/h3-8,13,15-16,19H,9-12,14H2,1-2H3,(H,29,33)(H,30,31,34) WPNIFSAMGAFSDO-UHFFFAOYSA-N 196321 US9212130, I-241 P2X purinoceptor 3 Homo sapiens 31 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196321 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196321&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68017428 318471668 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349216 CC(C)Oc1ccc(Nc2ncc(C(=O)NC3CCOCC3)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C26H28ClFN4O4/c1-16(2)36-23-8-7-20(13-22(23)28)31-26-29-14-21(24(33)30-19-9-11-35-12-10-19)25(34)32(26)15-17-3-5-18(27)6-4-17/h3-8,13-14,16,19H,9-12,15H2,1-2H3,(H,29,31)(H,30,33) UYLFWGFBCCPRRI-UHFFFAOYSA-N 196322 US9212130, I-242 P2X purinoceptor 3 Homo sapiens 67 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196322 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196322&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68017442 318471669 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349217 CC(C)Oc1ccc(Nc2ncc(N)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C20H20ClFN4O2/c1-12(2)28-18-8-7-15(9-16(18)22)25-20-24-10-17(23)19(27)26(20)11-13-3-5-14(21)6-4-13/h3-10,12H,11,23H2,1-2H3,(H,24,25) FOUGFJHLUNZUJB-UHFFFAOYSA-N 196323 US9212130, I-243 P2X purinoceptor 3 Homo sapiens 676 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196323 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196323&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68016932 318471670 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349218 Clc1ccc(Cn2c(Nc3ccc(Oc4cc[nH]c(=O)c4)cc3)ncc(NC(=O)C3CCOCC3)c2=O)cc1 InChI=1S/C28H26ClN5O5/c29-20-3-1-18(2-4-20)17-34-27(37)24(33-26(36)19-10-13-38-14-11-19)16-31-28(34)32-21-5-7-22(8-6-21)39-23-9-12-30-25(35)15-23/h1-9,12,15-16,19H,10-11,13-14,17H2,(H,30,35)(H,31,32)(H,33,36) JTYYHNYCGMTYNA-UHFFFAOYSA-N 196324 US9212130, I-244 P2X purinoceptor 3 Homo sapiens 2 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196324 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196324&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 77387207 318471671 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349219 Fc1cncc(Oc2ccc(Nc3ncc(NC(=O)C4CCOCC4)c(=O)n3Cc3ccc(Cl)cc3)cc2)c1 InChI=1S/C28H25ClFN5O4/c29-20-3-1-18(2-4-20)17-35-27(37)25(34-26(36)19-9-11-38-12-10-19)16-32-28(35)33-22-5-7-23(8-6-22)39-24-13-21(30)14-31-15-24/h1-8,13-16,19H,9-12,17H2,(H,32,33)(H,34,36) CVODADUHQXTXAP-UHFFFAOYSA-N 196325 US9212130, I-245 P2X purinoceptor 3 Homo sapiens 0.8 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196325 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196325&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68016933 318471672 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349220 CC(C)Oc1ccc(Nc2ncc(NC(C)=O)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C22H22ClFN4O3/c1-13(2)31-20-9-8-17(10-18(20)24)27-22-25-11-19(26-14(3)29)21(30)28(22)12-15-4-6-16(23)7-5-15/h4-11,13H,12H2,1-3H3,(H,25,27)(H,26,29) FIZFJXYLVPTSBN-UHFFFAOYSA-N 196326 US9212130, I-246 P2X purinoceptor 3 Homo sapiens 106 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196326 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196326&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68016931 318471673 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349221 CC(C)Oc1ccc(Nc2ncc(NC(=O)C(C)C)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C24H26ClFN4O3/c1-14(2)22(31)29-20-12-27-24(28-18-9-10-21(19(26)11-18)33-15(3)4)30(23(20)32)13-16-5-7-17(25)8-6-16/h5-12,14-15H,13H2,1-4H3,(H,27,28)(H,29,31) DJQUGZRTCBMBFK-UHFFFAOYSA-N 196327 US9212130, I-247 P2X purinoceptor 3 Homo sapiens 19 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196327 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196327&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68016937 318471674 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349222 COCCC(=O)Nc1cnc(Nc2ccc(OC(C)C)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H26ClFN4O4/c1-15(2)34-21-9-8-18(12-19(21)26)28-24-27-13-20(29-22(31)10-11-33-3)23(32)30(24)14-16-4-6-17(25)7-5-16/h4-9,12-13,15H,10-11,14H2,1-3H3,(H,27,28)(H,29,31) QURAZZHNEUDZTI-UHFFFAOYSA-N 196328 US9212130, I-248 P2X purinoceptor 3 Homo sapiens 24 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196328 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196328&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68017269 318471675 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 349223 COCC(=O)Nc1cnc(Nc2ccc(OC(C)C)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H24ClFN4O4/c1-14(2)33-20-9-8-17(10-18(20)25)27-23-26-11-19(28-21(30)13-32-3)22(31)29(23)12-15-4-6-16(24)7-5-15/h4-11,14H,12-13H2,1-3H3,(H,26,27)(H,28,30) GEFDZJIUJMRVRW-UHFFFAOYSA-N 196329 US9212130, I-249 P2X purinoceptor 3 Homo sapiens 35 7.5 US Patent 10.7270/Q2BG2MS2 aid1802002 US9212130 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196329 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196329&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68017273 318471676 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470467 CC(C)n1c(=O)nc(Nc2cccc(c2)C(F)(F)F)n(Cc2ccc(C)cc2)c1=O InChI=1S/C21H21F3N4O2/c1-13(2)28-19(29)26-18(25-17-6-4-5-16(11-17)21(22,23)24)27(20(28)30)12-15-9-7-14(3)8-10-15/h4-11,13H,12H2,1-3H3,(H,25,26,29) YOKVDDNYLFEVNF-UHFFFAOYSA-N 183071 US9150546, I-021::US9688643, I-021::US9718790, I-0021 P2X purinoceptor 3 Homo sapiens 197 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183071 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183071&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 75237521 313634471 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470468 CCCCn1c(=O)nc(Nc2cccc(c2)C(F)(F)F)n(Cc2ccc(C)cc2)c1=O InChI=1S/C22H23F3N4O2/c1-3-4-12-28-20(30)27-19(26-18-7-5-6-17(13-18)22(23,24)25)29(21(28)31)14-16-10-8-15(2)9-11-16/h5-11,13H,3-4,12,14H2,1-2H3,(H,26,27,30) CSTQVHSGLNKRJV-UHFFFAOYSA-N 183072 US9150546, I-029::US9688643, I-029::US9718790, I-0029 P2X purinoceptor 3 Homo sapiens 595 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183072 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183072&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 75237553 313634472 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470466 CC(C)n1c(=O)nc(Nc2cccc(c2)C(F)(F)F)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C20H18ClF3N4O2/c1-12(2)28-18(29)26-17(25-16-5-3-4-14(10-16)20(22,23)24)27(19(28)30)11-13-6-8-15(21)9-7-13/h3-10,12H,11H2,1-2H3,(H,25,26,29) UUGKLNMQRWYVRO-UHFFFAOYSA-N 183070 US9150546, I-020::US9688643, I-020::US9718790, I-0020 P2X purinoceptor 3 Homo sapiens 389 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183070 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183070&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821112 313634470 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470469 Cc1ccc(Cn2c(Nc3cccc(c3)C(F)(F)F)nc(=O)n(c2=O)C(C)(C)C)cc1 InChI=1S/C22H23F3N4O2/c1-14-8-10-15(11-9-14)13-28-18(27-19(30)29(20(28)31)21(2,3)4)26-17-7-5-6-16(12-17)22(23,24)25/h5-12H,13H2,1-4H3,(H,26,27,30) GSQTVLOBZSWCFK-UHFFFAOYSA-N 183073 US9150546, I-097::US9688643, I-097::US9718790, I-0097 P2X purinoceptor 3 Homo sapiens 505 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183073 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183073&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821135 313634473 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470470 CC(C)n1c(=O)nc(Nc2ccc(Oc3ccccc3)cc2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C26H26N4O3/c1-18(2)30-25(31)28-24(29(26(30)32)17-20-11-9-19(3)10-12-20)27-21-13-15-23(16-14-21)33-22-7-5-4-6-8-22/h4-16,18H,17H2,1-3H3,(H,27,28,31) WTXITHIOEDHEDI-UHFFFAOYSA-N 183074 US9150546, I-116::US9688643, I-116::US9718790, I-0116 P2X purinoceptor 3 Homo sapiens 484 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183074 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183074&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821393 313634474 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470471 CC(C)n1c(=O)nc(Nc2cccc(Cl)c2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C20H21ClN4O2/c1-13(2)25-19(26)23-18(22-17-6-4-5-16(21)11-17)24(20(25)27)12-15-9-7-14(3)8-10-15/h4-11,13H,12H2,1-3H3,(H,22,23,26) JDTYNPPCONPDCJ-UHFFFAOYSA-N 183075 US9150546, I-117::US9688643, I-117::US9718790, I-0117 P2X purinoceptor 3 Homo sapiens 387 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183075 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183075&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76820975 313634475 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470472 CSc1cccc(Nc2nc(=O)n(C(C)C)c(=O)n2Cc2ccc(C)cc2)c1 InChI=1S/C21H24N4O2S/c1-14(2)25-20(26)23-19(22-17-6-5-7-18(12-17)28-4)24(21(25)27)13-16-10-8-15(3)9-11-16/h5-12,14H,13H2,1-4H3,(H,22,23,26) SERAWUWTGODSSL-UHFFFAOYSA-N 183076 US9150546, I-118::US9688643, I-118::US9718790, I-0118 P2X purinoceptor 3 Homo sapiens 231 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183076 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183076&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 75237596 313634476 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470473 CC(C)Oc1ccc(Nc2nc(=O)n(C(C)C)c(=O)n2Cc2ccc(C)cc2)cc1 InChI=1S/C23H28N4O3/c1-15(2)27-22(28)25-21(24-19-10-12-20(13-11-19)30-16(3)4)26(23(27)29)14-18-8-6-17(5)7-9-18/h6-13,15-16H,14H2,1-5H3,(H,24,25,28) SFHXKQUAZHFZDZ-UHFFFAOYSA-N 183077 US9150546, I-121::US9688643, I-121::US9718790, I-0121 P2X purinoceptor 3 Homo sapiens 246 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183077 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183077&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821026 313634477 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470474 CC(C)n1c(=O)nc(Nc2ccc3[nH]ccc3c2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C22H23N5O2/c1-14(2)27-21(28)25-20(24-18-8-9-19-17(12-18)10-11-23-19)26(22(27)29)13-16-6-4-15(3)5-7-16/h4-12,14,23H,13H2,1-3H3,(H,24,25,28) VFEADJKRJBHYRS-UHFFFAOYSA-N 183078 US9150546, I-123::US9688643, I-123::US9718790, I-0123 P2X purinoceptor 3 Homo sapiens 815 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183078 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183078&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 75237597 313634478 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470475 CC(C)n1c(=O)nc(Nc2cccc(c2)C(F)(F)F)n(Cc2ccc(F)cc2)c1=O InChI=1S/C20H18F4N4O2/c1-12(2)28-18(29)26-17(25-16-5-3-4-14(10-16)20(22,23)24)27(19(28)30)11-13-6-8-15(21)9-7-13/h3-10,12H,11H2,1-2H3,(H,25,26,29) MSMVJAKQZYUCKV-UHFFFAOYSA-N 183079 US9150546, I-126::US9688643, I-126::US9718790, I-0126 P2X purinoceptor 3 Homo sapiens 689 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183079 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183079&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821386 313634479 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470476 CC(C)n1c(=O)nc(Nc2ccc(Oc3ccccc3)cc2)n(Cc2ccc(F)cc2)c1=O InChI=1S/C25H23FN4O3/c1-17(2)30-24(31)28-23(29(25(30)32)16-18-8-10-19(26)11-9-18)27-20-12-14-22(15-13-20)33-21-6-4-3-5-7-21/h3-15,17H,16H2,1-2H3,(H,27,28,31) CNSNAAGHAOMOPM-UHFFFAOYSA-N 183080 US9150546, I-128::US9688643, I-128::US9718790, I-0128 P2X purinoceptor 3 Homo sapiens 840 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183080 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183080&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821421 313634480 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470477 CSc1cccc(Nc2nc(=O)n(C(C)C)c(=O)n2Cc2ccc(F)cc2)c1 InChI=1S/C20H21FN4O2S/c1-13(2)25-19(26)23-18(22-16-5-4-6-17(11-16)28-3)24(20(25)27)12-14-7-9-15(21)10-8-14/h4-11,13H,12H2,1-3H3,(H,22,23,26) KUHNCTZRZIHMNZ-UHFFFAOYSA-N 183081 US9150546, I-130::US9688643, I-130::US9718790, I-0130 P2X purinoceptor 3 Homo sapiens 953 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183081 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183081&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821143 313634481 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470478 CC(C)Oc1ccc(Nc2nc(=O)n(C(C)C)c(=O)n2Cc2ccc(F)cc2)cc1 InChI=1S/C22H25FN4O3/c1-14(2)27-21(28)25-20(24-18-9-11-19(12-10-18)30-15(3)4)26(22(27)29)13-16-5-7-17(23)8-6-16/h5-12,14-15H,13H2,1-4H3,(H,24,25,28) CFGDBJCENZPXFT-UHFFFAOYSA-N 183082 US9150546, I-133::US9688643, I-133::US9718790, I-0133 P2X purinoceptor 3 Homo sapiens 339 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183082 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183082&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821219 313634482 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470479 CCn1c(=O)nc(Nc2cccc(c2)C(F)(F)F)n(Cc2ccc(F)cc2)c1=O InChI=1S/C19H16F4N4O2/c1-2-26-17(28)25-16(24-15-5-3-4-13(10-15)19(21,22)23)27(18(26)29)11-12-6-8-14(20)9-7-12/h3-10H,2,11H2,1H3,(H,24,25,28) VQUSPBTZXROEJD-UHFFFAOYSA-N 183083 US9150546, I-138::US9688643, I-138::US9718790, I-0138 P2X purinoceptor 3 Homo sapiens 619 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183083 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183083&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821341 313634483 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470480 CCn1c(=O)nc(Nc2ccc(Oc3ccccc3)cc2)n(Cc2ccc(F)cc2)c1=O InChI=1S/C24H21FN4O3/c1-2-28-23(30)27-22(29(24(28)31)16-17-8-10-18(25)11-9-17)26-19-12-14-21(15-13-19)32-20-6-4-3-5-7-20/h3-15H,2,16H2,1H3,(H,26,27,30) XYDHNFAHHWQXIT-UHFFFAOYSA-N 183084 US9150546, I-141::US9688643, I-141::US9718790, I-0141 P2X purinoceptor 3 Homo sapiens 685 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183084 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183084&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76820951 313634484 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470481 CC(C)n1c(=O)nc(Nc2cccc(c2)C(F)(F)F)n(Cc2ccc(Cl)cn2)c1=O InChI=1S/C19H17ClF3N5O2/c1-11(2)28-17(29)26-16(25-14-5-3-4-12(8-14)19(21,22)23)27(18(28)30)10-15-7-6-13(20)9-24-15/h3-9,11H,10H2,1-2H3,(H,25,26,29) YBSHZIGUKUOWCU-UHFFFAOYSA-N 183085 US9150546, I-162::US9688643, I-162::US9718790, I-0162 P2X purinoceptor 3 Homo sapiens 379 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183085 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183085&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821366 313634485 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470482 CC(C)n1c(=O)nc(Nc2ccc(Oc3ccccc3)cc2)n(Cc2ccc(Cl)cn2)c1=O InChI=1S/C24H22ClN5O3/c1-16(2)30-23(31)28-22(29(24(30)32)15-19-9-8-17(25)14-26-19)27-18-10-12-21(13-11-18)33-20-6-4-3-5-7-20/h3-14,16H,15H2,1-2H3,(H,27,28,31) BJIFHYQSYDRPLS-UHFFFAOYSA-N 183086 US9150546, I-164::US9688643, I-164::US9718790, I-0164 P2X purinoceptor 3 Homo sapiens 860 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183086 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183086&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821170 313634486 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470483 CC(C)n1c(=O)nc(Nc2cccc(OC(F)(F)F)c2)n(Cc2ccc(F)cc2)c1=O InChI=1S/C20H18F4N4O3/c1-12(2)28-18(29)26-17(25-15-4-3-5-16(10-15)31-20(22,23)24)27(19(28)30)11-13-6-8-14(21)9-7-13/h3-10,12H,11H2,1-2H3,(H,25,26,29) CFHUZVXARLKACN-UHFFFAOYSA-N 183087 US9150546, I-181::US9688643, I-181::US9718790, I-0181 P2X purinoceptor 3 Homo sapiens 985 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183087 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183087&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821033 313634487 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470484 CC(C)n1c(=O)nc(Nc2cccc(F)c2)n(Cc2ccc(F)cc2)c1=O InChI=1S/C19H18F2N4O2/c1-12(2)25-18(26)23-17(22-16-5-3-4-15(21)10-16)24(19(25)27)11-13-6-8-14(20)9-7-13/h3-10,12H,11H2,1-2H3,(H,22,23,26) PLOUZYMGEYTAOO-UHFFFAOYSA-N 183088 US9150546, I-182::US9688643, I-182::US9718790, I-0182 P2X purinoceptor 3 Homo sapiens 714 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183088 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183088&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821334 313634488 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470485 CC(C)Oc1ccc(Nc2nc(=O)n(C(C)C)c(=O)n2Cc2ccc(Cl)cc2)cc1 InChI=1S/C22H25ClN4O3/c1-14(2)27-21(28)25-20(24-18-9-11-19(12-10-18)30-15(3)4)26(22(27)29)13-16-5-7-17(23)8-6-16/h5-12,14-15H,13H2,1-4H3,(H,24,25,28) KRYNINNUFDZTED-UHFFFAOYSA-N 183089 US9150546, I-200::US9688643, I-200::US9718790, I-0200 P2X purinoceptor 3 Homo sapiens 128 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183089 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183089&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821207 313634489 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470486 CC(C)Oc1ccc(Nc2nc(=O)n(C(C)C)c(=O)n2Cc2ccc(F)cc2)cc1Cl InChI=1S/C22H24ClFN4O3/c1-13(2)28-21(29)26-20(25-17-9-10-19(18(23)11-17)31-14(3)4)27(22(28)30)12-15-5-7-16(24)8-6-15/h5-11,13-14H,12H2,1-4H3,(H,25,26,29) OWVXHUYXGFSYQY-UHFFFAOYSA-N 183090 US9150546, I-203::US9688643, I-203::US9718790, I-0203 P2X purinoceptor 3 Homo sapiens 110 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183090 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183090&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821264 313634490 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470487 CC(C)Oc1ccc(Nc2nc(=O)n(C(C)C)c(=O)n2Cc2ccc(F)cc2)cc1C(F)(F)F InChI=1S/C23H24F4N4O3/c1-13(2)31-21(32)29-20(30(22(31)33)12-15-5-7-16(24)8-6-15)28-17-9-10-19(34-14(3)4)18(11-17)23(25,26)27/h5-11,13-14H,12H2,1-4H3,(H,28,29,32) PTPBSADSFRUMGB-UHFFFAOYSA-N 183091 US9150546, I-204::US9688643, I-204::US9718790, I-0204 P2X purinoceptor 3 Homo sapiens 558 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183091 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183091&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821243 313634491 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470488 CC(C)Oc1ccc(Nc2nc(=O)n(C(C)C)c(=O)n2Cc2ccc(C)c(F)c2)cc1 InChI=1S/C23H27FN4O3/c1-14(2)28-22(29)26-21(25-18-8-10-19(11-9-18)31-15(3)4)27(23(28)30)13-17-7-6-16(5)20(24)12-17/h6-12,14-15H,13H2,1-5H3,(H,25,26,29) VXLKRVZZJMGIRW-UHFFFAOYSA-N 183092 US9150546, I-217::US9688643, I-217::US9718790, I-0217 P2X purinoceptor 3 Homo sapiens 268 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183092 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183092&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821277 313634492 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470489 CC(C)Oc1ccc(Nc2nc(=O)n(C(C)C)c(=O)n2Cc2ccc(C)c(c2)[N+]([O-])=O)cc1 InChI=1S/C23H27N5O5/c1-14(2)27-22(29)25-21(24-18-8-10-19(11-9-18)33-15(3)4)26(23(27)30)13-17-7-6-16(5)20(12-17)28(31)32/h6-12,14-15H,13H2,1-5H3,(H,24,25,29) DOEKZSQEACUAEJ-UHFFFAOYSA-N 183093 US9150546, I-218::US9688643, I-218::US9718790, I-0218 P2X purinoceptor 3 Homo sapiens 505 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183093 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183093&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 119099065 313634493 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470490 COC(=O)c1ccc(Nc2nc(=O)n(C(C)C)c(=O)n2Cc2ccc(F)cc2)cc1 InChI=1S/C21H21FN4O4/c1-13(2)26-20(28)24-19(23-17-10-6-15(7-11-17)18(27)30-3)25(21(26)29)12-14-4-8-16(22)9-5-14/h4-11,13H,12H2,1-3H3,(H,23,24,28) YCUSQGGRWIFGSQ-UHFFFAOYSA-N 183094 US9150546, I-221::US9688643, I-221::US9718790, I-0221 P2X purinoceptor 3 Homo sapiens 276 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183094 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183094&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821180 313634494 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470491 CC(C)n1c(=O)nc(NC(C)c2ccc(Cl)cc2)n(Cc2ccc(F)cc2)c1=O InChI=1S/C21H22ClFN4O2/c1-13(2)27-20(28)25-19(24-14(3)16-6-8-17(22)9-7-16)26(21(27)29)12-15-4-10-18(23)11-5-15/h4-11,13-14H,12H2,1-3H3,(H,24,25,28) AXDGKTCQGHHSCD-UHFFFAOYSA-N 183095 US9150546, I-223::US9688643, I-223::US9718790, I-0223 P2X purinoceptor 3 Homo sapiens 909 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183095 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183095&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821409 313634495 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470492 CC(C)Oc1ccc(Nc2nc(=O)n(C(C)C)c(=O)n2Cc2ccc(F)cc2)cc1C#N InChI=1S/C23H24FN5O3/c1-14(2)29-22(30)27-21(28(23(29)31)13-16-5-7-18(24)8-6-16)26-19-9-10-20(32-15(3)4)17(11-19)12-25/h5-11,14-15H,13H2,1-4H3,(H,26,27,30) RBEZCVPCKGYRNI-UHFFFAOYSA-N 183096 US9150546, I-227::US9688643, I-227::US9718790, I-0227 P2X purinoceptor 3 Homo sapiens 970 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183096 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183096&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821362 313634496 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470493 CC(C)Oc1ccc(Nc2nc(=O)n(C(C)C)c(=O)n2Cc2ccc(Cl)cc2)cc1Cl InChI=1S/C22H24Cl2N4O3/c1-13(2)28-21(29)26-20(25-17-9-10-19(18(24)11-17)31-14(3)4)27(22(28)30)12-15-5-7-16(23)8-6-15/h5-11,13-14H,12H2,1-4H3,(H,25,26,29) VRNDXKXJUGXSQA-UHFFFAOYSA-N 183097 US9150546, I-228::US9688643, I-228::US9718790, I-0228 P2X purinoceptor 3 Homo sapiens 31 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183097 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183097&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821066 313634497 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470494 CC(C)Oc1ccc(Nc2nc(=O)n(C(C)C)c(=O)n2Cc2ccc(Cl)cn2)cc1Cl InChI=1S/C21H23Cl2N5O3/c1-12(2)28-20(29)26-19(25-15-7-8-18(17(23)9-15)31-13(3)4)27(21(28)30)11-16-6-5-14(22)10-24-16/h5-10,12-13H,11H2,1-4H3,(H,25,26,29) AVXMYJGDEUEZIL-UHFFFAOYSA-N 183098 US9150546, I-234::US9688643, I-234::US9718790, I-0234 P2X purinoceptor 3 Homo sapiens 298 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183098 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183098&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821195 313634498 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470495 CC(C)Oc1ccc(Nc2nc(=O)n(C(C)C)c(=O)n2Cc2ccc(Cl)nc2)cc1Cl InChI=1S/C21H23Cl2N5O3/c1-12(2)28-20(29)26-19(25-15-6-7-17(16(22)9-15)31-13(3)4)27(21(28)30)11-14-5-8-18(23)24-10-14/h5-10,12-13H,11H2,1-4H3,(H,25,26,29) OKKVOHSWYVTAHO-UHFFFAOYSA-N 183099 US9150546, I-235::US9688643, I-235::US9718790, I-0235 P2X purinoceptor 3 Homo sapiens 985 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183099 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183099&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821064 313634499 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470496 COCCOc1ccc(Nc2nc(=O)n(C(C)C)c(=O)n2Cc2ccc(Cl)cc2)cc1Cl InChI=1S/C22H24Cl2N4O4/c1-14(2)28-21(29)26-20(27(22(28)30)13-15-4-6-16(23)7-5-15)25-17-8-9-19(18(24)12-17)32-11-10-31-3/h4-9,12,14H,10-11,13H2,1-3H3,(H,25,26,29) IAQHVVYKMDVUFT-UHFFFAOYSA-N 183100 US9150546, I-237::US9688643, I-237::US9718790, I-0237 P2X purinoceptor 3 Homo sapiens 230 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183100 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183100&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821247 313634500 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470497 COC(=O)c1ccc(Nc2nc(=O)n(C(C)C)c(=O)n2Cc2ccc(F)cc2)cc1Cl InChI=1S/C21H20ClFN4O4/c1-12(2)27-20(29)25-19(24-15-8-9-16(17(22)10-15)18(28)31-3)26(21(27)30)11-13-4-6-14(23)7-5-13/h4-10,12H,11H2,1-3H3,(H,24,25,29) UPIQRRIDCVZSEU-UHFFFAOYSA-N 183101 US9150546, I-238::US9688643, I-238::US9718790, I-0238 P2X purinoceptor 3 Homo sapiens 658 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183101 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183101&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76820978 313634501 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470498 CC(C)n1c(=O)nc(Nc2ccc(OC3CCOCC3)c(Cl)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H26Cl2N4O4/c1-15(2)30-23(31)28-22(29(24(30)32)14-16-3-5-17(25)6-4-16)27-18-7-8-21(20(26)13-18)34-19-9-11-33-12-10-19/h3-8,13,15,19H,9-12,14H2,1-2H3,(H,27,28,31) DDNUNYHYRGZFMC-UHFFFAOYSA-N 183102 US9150546, I-239::US9688643, I-239::US9718790, I-0239 P2X purinoceptor 3 Homo sapiens 116 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183102 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183102&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821040 313634502 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470499 CC(C)n1c(=O)nc(Nc2ccc(Oc3ccccc3)c(Cl)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H22Cl2N4O3/c1-16(2)31-24(32)29-23(30(25(31)33)15-17-8-10-18(26)11-9-17)28-19-12-13-22(21(27)14-19)34-20-6-4-3-5-7-20/h3-14,16H,15H2,1-2H3,(H,28,29,32) NFSZOFAKVQXYIY-UHFFFAOYSA-N 183103 US9150546, I-240::US9688643, I-240 P2X purinoceptor 3 Homo sapiens 953 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183103 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183103&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821125 313634503 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470503 CC(C)Oc1ccc(Nc2nc(=O)n(C(C)C)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C22H24ClFN4O3/c1-13(2)28-21(29)26-20(25-17-9-10-19(18(24)11-17)31-14(3)4)27(22(28)30)12-15-5-7-16(23)8-6-15/h5-11,13-14H,12H2,1-4H3,(H,25,26,29) NEEKIVKPSARQCC-UHFFFAOYSA-N 183107 US9150546, I-244::US9688643, I-244::US9718790, I-0244 P2X purinoceptor 3 Homo sapiens 45 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183107 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183107&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821359 313634507 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470500 CCOC(=O)COc1ccc(Nc2nc(=O)n(C(C)C)c(=O)n2Cc2ccc(Cl)cc2)cc1Cl InChI=1S/C23H24Cl2N4O5/c1-4-33-20(30)13-34-19-10-9-17(11-18(19)25)26-21-27-22(31)29(14(2)3)23(32)28(21)12-15-5-7-16(24)8-6-15/h5-11,14H,4,12-13H2,1-3H3,(H,26,27,31) YECJAZONJNUKOF-UHFFFAOYSA-N 183104 US9150546, I-241::US9688643, I-241::US9718790, I-0241 P2X purinoceptor 3 Homo sapiens 447 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183104 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183104&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821187 313634504 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470501 CC(C)n1c(=O)nc(Nc2ccc(OC3CCNCC3)c(Cl)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H27Cl2N5O3/c1-15(2)31-23(32)29-22(30(24(31)33)14-16-3-5-17(25)6-4-16)28-18-7-8-21(20(26)13-18)34-19-9-11-27-12-10-19/h3-8,13,15,19,27H,9-12,14H2,1-2H3,(H,28,29,32) LBCWOSHEBIVJGF-UHFFFAOYSA-N 183105 US9150546, I-242::US9688643, I-242::US9718790, I-0242 P2X purinoceptor 3 Homo sapiens 787 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183105 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183105&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76820942 313634505 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470502 COc1ccc(Nc2nc(=O)n(C(C)C)c(=O)n2Cc2ccc(Cl)cc2)cc1Cl InChI=1S/C20H20Cl2N4O3/c1-12(2)26-19(27)24-18(23-15-8-9-17(29-3)16(22)10-15)25(20(26)28)11-13-4-6-14(21)7-5-13/h4-10,12H,11H2,1-3H3,(H,23,24,27) MOCLUEIBJVFEID-UHFFFAOYSA-N 183106 US9150546, I-243::US9688643, I-243::US9718790, I-0243 P2X purinoceptor 3 Homo sapiens 450 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183106 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183106&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821167 313634506 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470504 CC(C)Oc1ccc(Nc2nc(=O)n(C(C)C)c(=O)n2Cc2ccc(Cl)cc2)cc1C#N InChI=1S/C23H24ClN5O3/c1-14(2)29-22(30)27-21(28(23(29)31)13-16-5-7-18(24)8-6-16)26-19-9-10-20(32-15(3)4)17(11-19)12-25/h5-11,14-15H,13H2,1-4H3,(H,26,27,30) XNSXTWGZTGQSMH-UHFFFAOYSA-N 183108 US9150546, I-245::US9688643, I-245::US9718790, I-0245 P2X purinoceptor 3 Homo sapiens 168 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183108 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183108&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76820964 313634508 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470505 CC(C)n1c(=O)nc(Nc2ccc3[nH]c(=O)oc3c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C20H18ClN5O4/c1-11(2)26-18(27)24-17(22-14-7-8-15-16(9-14)30-19(28)23-15)25(20(26)29)10-12-3-5-13(21)6-4-12/h3-9,11H,10H2,1-2H3,(H,23,28)(H,22,24,27) BRLFUVYLTKDYOS-UHFFFAOYSA-N 183109 US9150546, I-246::US9688643, I-246::US9718790, I-0246 P2X purinoceptor 3 Homo sapiens 996 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183109 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183109&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 77888198 313634509 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470506 COC(=O)c1ccc(Nc2nc(=O)n(C(C)C)c(=O)n2Cc2ccc(Cl)cc2)cc1 InChI=1S/C21H21ClN4O4/c1-13(2)26-20(28)24-19(23-17-10-6-15(7-11-17)18(27)30-3)25(21(26)29)12-14-4-8-16(22)9-5-14/h4-11,13H,12H2,1-3H3,(H,23,24,28) UDKRZHKBWBJIRH-UHFFFAOYSA-N 183110 US9150546, I-248::US9688643, I-248::US9718790, I-0248 P2X purinoceptor 3 Homo sapiens 420 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183110 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183110&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821342 313634510 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470507 CC(C)Oc1ccc(Nc2nc(=O)n(C(C)C)c(=O)n2Cc2ccc(Cl)s2)cc1F InChI=1S/C20H22ClFN4O3S/c1-11(2)26-19(27)24-18(25(20(26)28)10-14-6-8-17(21)30-14)23-13-5-7-16(15(22)9-13)29-12(3)4/h5-9,11-12H,10H2,1-4H3,(H,23,24,27) VRGLWZSDHZCAOI-UHFFFAOYSA-N 183111 US9150546, I-254::US9688643, I-254::US9718790, I-0254 P2X purinoceptor 3 Homo sapiens 144 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183111 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183111&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821021 313634511 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470508 CC(C)NC(=O)c1ccc(Nc2nc(=O)n(C(C)C)c(=O)n2Cc2ccc(Cl)cc2)cc1 InChI=1S/C23H26ClN5O3/c1-14(2)25-20(30)17-7-11-19(12-8-17)26-21-27-22(31)29(15(3)4)23(32)28(21)13-16-5-9-18(24)10-6-16/h5-12,14-15H,13H2,1-4H3,(H,25,30)(H,26,27,31) SIGZERSAIQXHMB-UHFFFAOYSA-N 183112 US9150546, I-255::US9688643, I-255::US9718790, I-0255 P2X purinoceptor 3 Homo sapiens 520 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183112 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183112&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821432 313634512 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470509 CC(C)CNC(=O)c1ccc(Nc2nc(=O)n(C(C)C)c(=O)n2Cc2ccc(Cl)cc2)cc1 InChI=1S/C24H28ClN5O3/c1-15(2)13-26-21(31)18-7-11-20(12-8-18)27-22-28-23(32)30(16(3)4)24(33)29(22)14-17-5-9-19(25)10-6-17/h5-12,15-16H,13-14H2,1-4H3,(H,26,31)(H,27,28,32) HXHVMCCJJHMFTF-UHFFFAOYSA-N 183113 US9150546, I-256::US9688643, I-256::US9718790, I-0256 P2X purinoceptor 3 Homo sapiens 867 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183113 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183113&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821253 313634513 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470510 CC(C)n1c(=O)nc(Nc2ccc(cc2)C(=O)NC2CC2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H24ClN5O3/c1-14(2)29-22(31)27-21(28(23(29)32)13-15-3-7-17(24)8-4-15)26-19-9-5-16(6-10-19)20(30)25-18-11-12-18/h3-10,14,18H,11-13H2,1-2H3,(H,25,30)(H,26,27,31) KLIMXRDHTVGIJE-UHFFFAOYSA-N 183114 US9150546, I-257::US9688643, I-257::US9718790, I-0257 P2X purinoceptor 3 Homo sapiens 682 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183114 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183114&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821283 313634514 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470511 CC(C)n1c(=O)nc(Nc2ccc(cc2)C(=O)NCC2CC2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H26ClN5O3/c1-15(2)30-23(32)28-22(29(24(30)33)14-17-5-9-19(25)10-6-17)27-20-11-7-18(8-12-20)21(31)26-13-16-3-4-16/h5-12,15-16H,3-4,13-14H2,1-2H3,(H,26,31)(H,27,28,32) WGVHUASKTDZQAF-UHFFFAOYSA-N 183115 US9150546, I-258::US9688643, I-258::US9718790, I-0258 P2X purinoceptor 3 Homo sapiens 683 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183115 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183115&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821435 313634515 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470512 CC(C)n1c(=O)nc(Nc2ccc(cc2)C(=O)Nc2ccccc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H24ClN5O3/c1-17(2)32-25(34)30-24(31(26(32)35)16-18-8-12-20(27)13-9-18)29-22-14-10-19(11-15-22)23(33)28-21-6-4-3-5-7-21/h3-15,17H,16H2,1-2H3,(H,28,33)(H,29,30,34) SOXGLRSLVYLHIY-UHFFFAOYSA-N 183116 US9150546, I-266::US9688643, I-266 P2X purinoceptor 3 Homo sapiens 861 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183116 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183116&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821321 313634516 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470513 CC(C)Oc1ccc(Nc2nc(=O)[nH]c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C19H18ClFN4O3/c1-11(2)28-16-8-7-14(9-15(16)21)22-17-23-18(26)24-19(27)25(17)10-12-3-5-13(20)6-4-12/h3-9,11H,10H2,1-2H3,(H2,22,23,24,26,27) AJVAAPSNYAVHDF-UHFFFAOYSA-N 183117 US9150546, I-269::US9688643, I-269::US9718790, I-0269 P2X purinoceptor 3 Homo sapiens 415 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183117 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183117&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76820948 313634517 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470514 COc1cc(Cl)ccc1Cn1c(Nc2ccc(OC(C)C)c(F)c2)nc(=O)n(C(C)C)c1=O InChI=1S/C23H26ClFN4O4/c1-13(2)29-22(30)27-21(26-17-8-9-19(18(25)11-17)33-14(3)4)28(23(29)31)12-15-6-7-16(24)10-20(15)32-5/h6-11,13-14H,12H2,1-5H3,(H,26,27,30) GTFVMMIIRJHQNA-UHFFFAOYSA-N 183118 US9150546, I-270::US9688643, I-270::US9718790, I-0270 P2X purinoceptor 3 Homo sapiens 271 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183118 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183118&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821318 313634518 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470515 CC(C)Oc1ccc(Nc2nc(=O)n(CC3CC3)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C23H24ClFN4O3/c1-14(2)32-20-10-9-18(11-19(20)25)26-21-27-22(30)29(13-15-3-4-15)23(31)28(21)12-16-5-7-17(24)8-6-16/h5-11,14-15H,3-4,12-13H2,1-2H3,(H,26,27,30) KWLZBQHILCASGJ-UHFFFAOYSA-N 183119 US9150546, I-271::US9688643, I-271::US9718790, I-0271 P2X purinoceptor 3 Homo sapiens 32 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183119 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183119&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821043 313634519 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470516 CC(C)Oc1ccc(Nc2nc(=O)n(CCN(C)C)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C23H27ClFN5O3/c1-15(2)33-20-10-9-18(13-19(20)25)26-21-27-22(31)29(12-11-28(3)4)23(32)30(21)14-16-5-7-17(24)8-6-16/h5-10,13,15H,11-12,14H2,1-4H3,(H,26,27,31) UCAYJQSCZMASBW-UHFFFAOYSA-N 183120 US9150546, I-272::US9688643, I-272::US9718790, I-0272 P2X purinoceptor 3 Homo sapiens 180 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183120 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183120&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821009 313634520 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470517 CC(C)Oc1ccc(Nc2nc(=O)n(CCO)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C21H22ClFN4O4/c1-13(2)31-18-8-7-16(11-17(18)23)24-19-25-20(29)26(9-10-28)21(30)27(19)12-14-3-5-15(22)6-4-14/h3-8,11,13,28H,9-10,12H2,1-2H3,(H,24,25,29) XKUBPFCGXISTNR-UHFFFAOYSA-N 183121 US9150546, I-273::US9688643, I-273::US9718790, I-0273 P2X purinoceptor 3 Homo sapiens 38 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183121 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183121&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821279 313634521 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470518 CC(C)Oc1ccc(Nc2nc(=O)n(CC(C)(CO)CO)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C24H28ClFN4O5/c1-15(2)35-20-9-8-18(10-19(20)26)27-21-28-22(33)30(12-24(3,13-31)14-32)23(34)29(21)11-16-4-6-17(25)7-5-16/h4-10,15,31-32H,11-14H2,1-3H3,(H,27,28,33) UTJLWFYQRDUGFC-UHFFFAOYSA-N 183122 US9150546, I-274::US9688643, I-274::US9718790, I-0274 P2X purinoceptor 3 Homo sapiens 9.00 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183122 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183122&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76388509 313634522 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470519 CC(C)Oc1ccc(Nc2nc(=O)n(CC3CCOCC3)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C25H28ClFN4O4/c1-16(2)35-22-8-7-20(13-21(22)27)28-23-29-24(32)31(15-18-9-11-34-12-10-18)25(33)30(23)14-17-3-5-19(26)6-4-17/h3-8,13,16,18H,9-12,14-15H2,1-2H3,(H,28,29,32) KMGNDJHSKCRYEF-UHFFFAOYSA-N 183123 US9150546, I-275::US9688643, I-275::US9718790, I-0275 P2X purinoceptor 3 Homo sapiens 21 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183123 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183123&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821452 313634523 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470520 CC(C)Oc1ccc(Nc2nc(=O)n(CC(CO)CO)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C23H26ClFN4O5/c1-14(2)34-20-8-7-18(9-19(20)25)26-21-27-22(32)29(11-16(12-30)13-31)23(33)28(21)10-15-3-5-17(24)6-4-15/h3-9,14,16,30-31H,10-13H2,1-2H3,(H,26,27,32) RUZOIAXGYPSNOT-UHFFFAOYSA-N 183124 US9150546, I-276::US9688643, I-276::US9718790, I-0276 P2X purinoceptor 3 Homo sapiens 12 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183124 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183124&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821269 313634524 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470521 CCn1c(=O)nc(Nc2ccc(OC(C)C)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C21H22ClFN4O3/c1-4-26-20(28)25-19(24-16-9-10-18(17(23)11-16)30-13(2)3)27(21(26)29)12-14-5-7-15(22)8-6-14/h5-11,13H,4,12H2,1-3H3,(H,24,25,28) ZFOLLFDANAKBTB-UHFFFAOYSA-N 183125 US9150546, I-277::US9688643, I-277::US9718790, I-0277 P2X purinoceptor 3 Homo sapiens 38 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183125 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183125&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821275 313634525 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470522 OCCn1c(=O)nc(Nc2ccc(cc2)-c2ccon2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C21H18ClN5O4/c22-16-5-1-14(2-6-16)13-27-19(24-20(29)26(10-11-28)21(27)30)23-17-7-3-15(4-8-17)18-9-12-31-25-18/h1-9,12,28H,10-11,13H2,(H,23,24,29) IBYTZLXTXPKYSB-UHFFFAOYSA-N 183126 US9150546, I-278::US9688643, I-278::US9718790, I-0278 P2X purinoceptor 3 Homo sapiens 931 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183126 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183126&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821140 313634526 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470523 COCCn1c(=O)nc(Nc2ccc(OC(C)C)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C22H24ClFN4O4/c1-14(2)32-19-9-8-17(12-18(19)24)25-20-26-21(29)27(10-11-31-3)22(30)28(20)13-15-4-6-16(23)7-5-15/h4-9,12,14H,10-11,13H2,1-3H3,(H,25,26,29) LFPJLMIAJIYGIU-UHFFFAOYSA-N 183127 US9150546, I-280::US9688643, I-280::US9718790, I-0280 P2X purinoceptor 3 Homo sapiens 30 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183127 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183127&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821447 313634527 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470524 CC(C)Oc1ccc(Nc2nc(=O)n(CCN3CCOCC3)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C25H29ClFN5O4/c1-17(2)36-22-8-7-20(15-21(22)27)28-23-29-24(33)31(10-9-30-11-13-35-14-12-30)25(34)32(23)16-18-3-5-19(26)6-4-18/h3-8,15,17H,9-14,16H2,1-2H3,(H,28,29,33) TVASFVKDNGFONS-UHFFFAOYSA-N 183128 US9150546, I-281::US9688643, I-281::US9718790, I-0281 P2X purinoceptor 3 Homo sapiens 12 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183128 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183128&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821220 313634528 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470525 CC(C)Oc1ccc(Nc2nc(=O)n(CCN3CCCCC3)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C26H31ClFN5O3/c1-18(2)36-23-11-10-21(16-22(23)28)29-24-30-25(34)32(15-14-31-12-4-3-5-13-31)26(35)33(24)17-19-6-8-20(27)9-7-19/h6-11,16,18H,3-5,12-15,17H2,1-2H3,(H,29,30,34) AQIFGVPXDZVNGA-UHFFFAOYSA-N 183129 US9150546, I-282::US9688643, I-282::US9718790, I-0282 P2X purinoceptor 3 Homo sapiens 27 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183129 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183129&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821381 313634529 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470526 CC(C)Oc1ccc(Nc2nc(=O)n(CC(F)(F)C(O)=O)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C22H20ClF3N4O5/c1-12(2)35-17-8-7-15(9-16(17)24)27-19-28-20(33)30(11-22(25,26)18(31)32)21(34)29(19)10-13-3-5-14(23)6-4-13/h3-9,12H,10-11H2,1-2H3,(H,31,32)(H,27,28,33) IXCROGNFOOAIDL-UHFFFAOYSA-N 183130 US9150546, I-283::US9688643, I-283::US9718790, I-0283 P2X purinoceptor 3 Homo sapiens 19 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183130 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183130&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821358 313634530 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470527 CC(C)Oc1ccc(Nc2nc(=O)n(CC(O)=O)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C21H20ClFN4O5/c1-12(2)32-17-8-7-15(9-16(17)23)24-19-25-20(30)27(11-18(28)29)21(31)26(19)10-13-3-5-14(22)6-4-13/h3-9,12H,10-11H2,1-2H3,(H,28,29)(H,24,25,30) PLIWLWCQSVFBEL-UHFFFAOYSA-N 183131 US9150546, I-284::US9688643, I-284::US9718790, I-0284 P2X purinoceptor 3 Homo sapiens 629 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183131 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183131&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76820980 313634531 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470528 CC(C)Oc1ccc(Nc2nc(=O)n(CCCO)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C22H24ClFN4O4/c1-14(2)32-19-9-8-17(12-18(19)24)25-20-26-21(30)27(10-3-11-29)22(31)28(20)13-15-4-6-16(23)7-5-15/h4-9,12,14,29H,3,10-11,13H2,1-2H3,(H,25,26,30) NOTRDLDWXSPKCF-UHFFFAOYSA-N 183132 US9150546, I-285::US9688643, I-285::US9718790, I-0285 P2X purinoceptor 3 Homo sapiens 14 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183132 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183132&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821080 313634532 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470529 CC(C)Oc1ccc(Nc2nc(=O)n(C(CO)CO)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C22H24ClFN4O5/c1-13(2)33-19-8-7-16(9-18(19)24)25-20-26-21(31)28(17(11-29)12-30)22(32)27(20)10-14-3-5-15(23)6-4-14/h3-9,13,17,29-30H,10-12H2,1-2H3,(H,25,26,31) MSADNIYDADHRDA-UHFFFAOYSA-N 183133 US9150546, I-286::US9688643, I-286::US9718790, I-0286 P2X purinoceptor 3 Homo sapiens 277 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183133 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183133&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821257 313634533 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470530 Clc1ccc(Cn2c(Nc3ccc(cc3)-c3ccon3)nc(=O)n(CCN3CCOCC3)c2=O)cc1 InChI=1S/C25H25ClN6O4/c26-20-5-1-18(2-6-20)17-32-23(27-21-7-3-19(4-8-21)22-9-14-36-29-22)28-24(33)31(25(32)34)11-10-30-12-15-35-16-13-30/h1-9,14H,10-13,15-17H2,(H,27,28,33) HZBDYVIANCHSDU-UHFFFAOYSA-N 183134 US9150546, I-287::US9688643, I-287::US9718790, I-0287 P2X purinoceptor 3 Homo sapiens 222 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183134 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183134&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821177 313634534 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470531 CC(C)Oc1ccc(Nc2nc(=O)n(CC#N)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C21H19ClFN5O3/c1-13(2)31-18-8-7-16(11-17(18)23)25-19-26-20(29)27(10-9-24)21(30)28(19)12-14-3-5-15(22)6-4-14/h3-8,11,13H,10,12H2,1-2H3,(H,25,26,29) SHZBDZQJVOICIK-UHFFFAOYSA-N 183135 US9150546, I-288::US9688643, I-288::US9718790, I-0288 P2X purinoceptor 3 Homo sapiens 93 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183135 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183135&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821284 313634535 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470532 CC(C)Oc1ccc(Nc2nc(=O)n(CCC(O)=O)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C22H22ClFN4O5/c1-13(2)33-18-8-7-16(11-17(18)24)25-20-26-21(31)27(10-9-19(29)30)22(32)28(20)12-14-3-5-15(23)6-4-14/h3-8,11,13H,9-10,12H2,1-2H3,(H,29,30)(H,25,26,31) MCTZNTUJEJXMFG-UHFFFAOYSA-N 183136 US9150546, I-289::US9688643, I-289::US9718790, I-0289 P2X purinoceptor 3 Homo sapiens 66 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183136 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183136&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821389 313634536 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470533 CC(C)Oc1ccc(Nc2nc(=O)n(CCN)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C21H23ClFN5O3/c1-13(2)31-18-8-7-16(11-17(18)23)25-19-26-20(29)27(10-9-24)21(30)28(19)12-14-3-5-15(22)6-4-14/h3-8,11,13H,9-10,12,24H2,1-2H3,(H,25,26,29) SAZRRLWYPWSLHE-UHFFFAOYSA-N 183137 US9150546, I-290::US9688643, I-290::US9718790, I-0290 P2X purinoceptor 3 Homo sapiens 266 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183137 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183137&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821151 313634537 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470534 CC(C)Oc1ccc(Nc2nc(=O)n(CCC#N)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C22H21ClFN5O3/c1-14(2)32-19-9-8-17(12-18(19)24)26-20-27-21(30)28(11-3-10-25)22(31)29(20)13-15-4-6-16(23)7-5-15/h4-9,12,14H,3,11,13H2,1-2H3,(H,26,27,30) MUAVUCGFIWKKLX-UHFFFAOYSA-N 183138 US9150546, I-291::US9688643, I-291::US9718790, I-0291 P2X purinoceptor 3 Homo sapiens 9.00 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183138 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183138&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821316 313634538 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470535 CC(C)Oc1ccc(Nc2nc(=O)n(CCNC(C)=O)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C23H25ClFN5O4/c1-14(2)34-20-9-8-18(12-19(20)25)27-21-28-22(32)29(11-10-26-15(3)31)23(33)30(21)13-16-4-6-17(24)7-5-16/h4-9,12,14H,10-11,13H2,1-3H3,(H,26,31)(H,27,28,32) VLKNEIAWFTVSEB-UHFFFAOYSA-N 183139 US9150546, I-292::US9688643, I-292::US9718790, I-0292 P2X purinoceptor 3 Homo sapiens 34 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183139 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183139&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 77393823 313634539 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470536 CC(C)Oc1ccc(Nc2nc(=O)n(CC(=O)N(C)C)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C23H25ClFN5O4/c1-14(2)34-19-10-9-17(11-18(19)25)26-21-27-22(32)30(13-20(31)28(3)4)23(33)29(21)12-15-5-7-16(24)8-6-15/h5-11,14H,12-13H2,1-4H3,(H,26,27,32) RCVSMVSKFKNQJB-UHFFFAOYSA-N 183140 US9150546, I-293::US9688643, I-293::US9718790, I-0293 P2X purinoceptor 3 Homo sapiens 351 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183140 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183140&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821093 313634540 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470537 CNC(=O)Cn1c(=O)nc(Nc2ccc(OC(C)C)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C22H23ClFN5O4/c1-13(2)33-18-9-8-16(10-17(18)24)26-20-27-21(31)29(12-19(30)25-3)22(32)28(20)11-14-4-6-15(23)7-5-14/h4-10,13H,11-12H2,1-3H3,(H,25,30)(H,26,27,31) PCFINRYADQXVKE-UHFFFAOYSA-N 183141 US9150546, I-294::US9688643, I-294::US9718790, I-0294 P2X purinoceptor 3 Homo sapiens 40 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183141 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183141&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76820949 313634541 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470538 CC(C)Oc1ccc(Nc2nc(=O)n(CC(N)=O)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C21H21ClFN5O4/c1-12(2)32-17-8-7-15(9-16(17)23)25-19-26-20(30)28(11-18(24)29)21(31)27(19)10-13-3-5-14(22)6-4-13/h3-9,12H,10-11H2,1-2H3,(H2,24,29)(H,25,26,30) XUQJWMNWTZFCLU-UHFFFAOYSA-N 183142 US9150546, I-295::US9688643, I-295::US9718790, I-0295 P2X purinoceptor 3 Homo sapiens 46 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183142 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183142&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821065 313634542 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470539 CC(C)Oc1ccc(Nc2nc(=O)n(C(C)=O)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C21H20ClFN4O4/c1-12(2)31-18-9-8-16(10-17(18)23)24-19-25-20(29)27(13(3)28)21(30)26(19)11-14-4-6-15(22)7-5-14/h4-10,12H,11H2,1-3H3,(H,24,25,29) TZVHQOORWPGESA-UHFFFAOYSA-N 183143 US9150546, I-296::US9688643, I-296::US9718790, I-0296 P2X purinoceptor 3 Homo sapiens 176 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183143 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183143&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821385 313634543 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470540 CC(C)Oc1ccc(Nc2nc(=O)n(CCC(=O)N(C)C)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C24H27ClFN5O4/c1-15(2)35-20-10-9-18(13-19(20)26)27-22-28-23(33)30(12-11-21(32)29(3)4)24(34)31(22)14-16-5-7-17(25)8-6-16/h5-10,13,15H,11-12,14H2,1-4H3,(H,27,28,33) SNURGCWNVNKCDB-UHFFFAOYSA-N 183144 US9150546, I-297::US9688643, I-297::US9718790, I-0297 P2X purinoceptor 3 Homo sapiens 45 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183144 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183144&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821416 313634544 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470541 CNC(=O)CCn1c(=O)nc(Nc2ccc(OC(C)C)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H25ClFN5O4/c1-14(2)34-19-9-8-17(12-18(19)25)27-21-28-22(32)29(11-10-20(31)26-3)23(33)30(21)13-15-4-6-16(24)7-5-15/h4-9,12,14H,10-11,13H2,1-3H3,(H,26,31)(H,27,28,32) XGSOCLWAPUYZQU-UHFFFAOYSA-N 183145 US9150546, I-298::US9688643, I-298::US9718790, I-0298 P2X purinoceptor 3 Homo sapiens 27 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183145 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183145&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821333 313634545 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470542 CC(C)Oc1ccc(Nc2nc(=O)n(CCC(N)=O)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C22H23ClFN5O4/c1-13(2)33-18-8-7-16(11-17(18)24)26-20-27-21(31)28(10-9-19(25)30)22(32)29(20)12-14-3-5-15(23)6-4-14/h3-8,11,13H,9-10,12H2,1-2H3,(H2,25,30)(H,26,27,31) UFFMZHJMYPBKRN-UHFFFAOYSA-N 183146 US9150546, I-299::US9688643, I-299::US9718790, I-0299 P2X purinoceptor 3 Homo sapiens 46 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183146 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183146&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821155 313634546 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470543 CC(C)Oc1ccc(Nc2nc(=O)n(Cc3ccccn3)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C25H23ClFN5O3/c1-16(2)35-22-11-10-19(13-21(22)27)29-23-30-24(33)32(15-20-5-3-4-12-28-20)25(34)31(23)14-17-6-8-18(26)9-7-17/h3-13,16H,14-15H2,1-2H3,(H,29,30,33) XXENJCJYUMNOPR-UHFFFAOYSA-N 183147 US9150546, I-300::US9688643, I-300::US9718790, I-0300 P2X purinoceptor 3 Homo sapiens 25 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183147 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183147&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821289 313634547 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470544 CC(C)Oc1ccc(Nc2nc(=O)n(Cc3ccccc3)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C26H24ClFN4O3/c1-17(2)35-23-13-12-21(14-22(23)28)29-24-30-25(33)32(16-18-6-4-3-5-7-18)26(34)31(24)15-19-8-10-20(27)11-9-19/h3-14,17H,15-16H2,1-2H3,(H,29,30,33) CRXFJQFRHPYGEW-UHFFFAOYSA-N 183148 US9150546, I-301::US9688643, I-301::US9718790, I-0301 P2X purinoceptor 3 Homo sapiens 48 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183148 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183148&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821148 313634548 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470545 COc1ccc(Nc2nc(=O)n(CCO)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C19H18ClFN4O4/c1-29-16-7-6-14(10-15(16)21)22-17-23-18(27)24(8-9-26)19(28)25(17)11-12-2-4-13(20)5-3-12/h2-7,10,26H,8-9,11H2,1H3,(H,22,23,27) VQLURVNMKVRPBI-UHFFFAOYSA-N 183149 US9150546, I-305::US9688643, I-305::US9718790, I-0305 P2X purinoceptor 3 Homo sapiens 946 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183149 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183149&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821291 313634549 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470546 CCOc1ccc(Nc2nc(=O)n(CCO)c(=O)n2Cc2ccc(Cl)cc2)cc1 InChI=1S/C20H21ClN4O4/c1-2-29-17-9-7-16(8-10-17)22-18-23-19(27)24(11-12-26)20(28)25(18)13-14-3-5-15(21)6-4-14/h3-10,26H,2,11-13H2,1H3,(H,22,23,27) PCNUGCNYROAAGW-UHFFFAOYSA-N 183150 US9150546, I-307::US9688643, I-307::US9718790, I-0307 P2X purinoceptor 3 Homo sapiens 250 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183150 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183150&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821438 313634550 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470547 OCCn1c(=O)nc(Nc2cccc(OC(F)(F)F)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C19H16ClF3N4O4/c20-13-6-4-12(5-7-13)11-27-16(25-17(29)26(8-9-28)18(27)30)24-14-2-1-3-15(10-14)31-19(21,22)23/h1-7,10,28H,8-9,11H2,(H,24,25,29) SZPOVAGBNOSRKL-UHFFFAOYSA-N 183151 US9150546, I-309::US9688643, I-309::US9718790, I-0309 P2X purinoceptor 3 Homo sapiens 357 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183151 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183151&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821085 313634551 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470548 CC(C)Oc1ccc(Nc2nc(=O)n(C(F)F)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C20H18ClF3N4O3/c1-11(2)31-16-8-7-14(9-15(16)22)25-18-26-19(29)28(17(23)24)20(30)27(18)10-12-3-5-13(21)6-4-12/h3-9,11,17H,10H2,1-2H3,(H,25,26,29) UKOOLOVTENGDOT-UHFFFAOYSA-N 183152 US9150546, I-310::US9688643, I-310::US9718790, I-0310 P2X purinoceptor 3 Homo sapiens 389 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183152 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183152&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821325 313634552 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470549 OCCn1c(=O)nc(Nc2ccc(cc2)N2CCCCC2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H26ClN5O3/c24-18-6-4-17(5-7-18)16-29-21(26-22(31)28(14-15-30)23(29)32)25-19-8-10-20(11-9-19)27-12-2-1-3-13-27/h4-11,30H,1-3,12-16H2,(H,25,26,31) OJQRPQPOPGAGNZ-UHFFFAOYSA-N 183153 US9150546, I-311::US9688643, I-311::US9718790, I-0311 P2X purinoceptor 3 Homo sapiens 142 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183153 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183153&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821457 313634553 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470550 CCOc1ccc(Nc2nc(=O)n(CCO)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C20H20ClFN4O4/c1-2-30-17-8-7-15(11-16(17)22)23-18-24-19(28)25(9-10-27)20(29)26(18)12-13-3-5-14(21)6-4-13/h3-8,11,27H,2,9-10,12H2,1H3,(H,23,24,28) UVRGSNWJIMHPJR-UHFFFAOYSA-N 183154 US9150546, I-312::US9688643, I-312::US9718790, I-0312 P2X purinoceptor 3 Homo sapiens 104 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183154 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183154&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76820982 313634554 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470551 OCCn1c(=O)nc(Nc2cccc(c2)C(F)(F)F)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C19H16ClF3N4O3/c20-14-6-4-12(5-7-14)11-27-16(25-17(29)26(8-9-28)18(27)30)24-15-3-1-2-13(10-15)19(21,22)23/h1-7,10,28H,8-9,11H2,(H,24,25,29) GNJMVKXDASLTBV-UHFFFAOYSA-N 183155 US9150546, I-313::US9688643, I-313::US9718790, I-0313 P2X purinoceptor 3 Homo sapiens 178 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183155 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183155&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821293 313634555 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470552 OCCn1c(=O)nc(Nc2cccc(c2)-c2ccon2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C21H18ClN5O4/c22-16-6-4-14(5-7-16)13-27-19(24-20(29)26(9-10-28)21(27)30)23-17-3-1-2-15(12-17)18-8-11-31-25-18/h1-8,11-12,28H,9-10,13H2,(H,23,24,29) DDPKJFUGSSHNQH-UHFFFAOYSA-N 183156 US9150546, I-314::US9688643, I-314::US9718790, I-0314 P2X purinoceptor 3 Homo sapiens 555 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183156 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183156&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821005 313634556 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470553 OCCn1c(=O)nc(Nc2ccc(c(F)c2)C(F)(F)F)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C19H15ClF4N4O3/c20-12-3-1-11(2-4-12)10-28-16(26-17(30)27(7-8-29)18(28)31)25-13-5-6-14(15(21)9-13)19(22,23)24/h1-6,9,29H,7-8,10H2,(H,25,26,30) DGUIURWTUWHUDG-UHFFFAOYSA-N 183157 US9150546, I-315::US9688643, I-315::US9718790, I-0315 P2X purinoceptor 3 Homo sapiens 183 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183157 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183157&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821237 313634557 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470554 OCCn1c(=O)nc(Nc2ccc(F)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C18H15ClF2N4O3/c19-12-3-1-11(2-4-12)10-25-16(22-13-5-6-14(20)15(21)9-13)23-17(27)24(7-8-26)18(25)28/h1-6,9,26H,7-8,10H2,(H,22,23,27) SPLPIBKXRGJGLE-UHFFFAOYSA-N 183158 US9150546, I-316::US9688643, I-316::US9718790, I-0316 P2X purinoceptor 3 Homo sapiens 712 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183158 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183158&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821214 313634558 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470555 CC(C)Oc1ccc(Nc2nc(=O)n(CCCN)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C22H25ClFN5O3/c1-14(2)32-19-9-8-17(12-18(19)24)26-20-27-21(30)28(11-3-10-25)22(31)29(20)13-15-4-6-16(23)7-5-15/h4-9,12,14H,3,10-11,13,25H2,1-2H3,(H,26,27,30) OIMNDBFRVLTWKG-UHFFFAOYSA-N 183159 US9150546, I-317::US9688643, I-317::US9718790, I-0317 P2X purinoceptor 3 Homo sapiens 137 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183159 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183159&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821352 313634559 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470556 CC(C)Oc1ccc(Nc2nc(=O)n(CCO)c(=O)n2Cc2ccc(Cl)cc2)cc1 InChI=1S/C21H23ClN4O4/c1-14(2)30-18-9-7-17(8-10-18)23-19-24-20(28)25(11-12-27)21(29)26(19)13-15-3-5-16(22)6-4-15/h3-10,14,27H,11-13H2,1-2H3,(H,23,24,28) WNEKFDBSKZECEH-UHFFFAOYSA-N 183160 US9150546, I-320::US9688643, I-320::US9718790, I-0320 P2X purinoceptor 3 Homo sapiens 83 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183160 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183160&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821401 313634560 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 50203137 Cc1ccc(cc1NC(=O)c1cccc(NC(=O)Nc2cccc(c2)C(=O)Nc2cc(ccc2C)C(=O)Nc2ccc(c3cc(cc(c23)S(O)(=O)=O)S(O)(=O)=O)S(O)(=O)=O)c1)C(=O)Nc1ccc(c2cc(cc(c12)S(O)(=O)=O)S(O)(=O)=O)S(O)(=O)=O InChI=1S/C51H40N6O23S6/c1-25-9-11-29(49(60)54-37-13-15-41(83(69,70)71)35-21-33(81(63,64)65)23-43(45(35)37)85(75,76)77)19-39(25)56-47(58)27-5-3-7-31(17-27)52-51(62)53-32-8-4-6-28(18-32)48(59)57-40-20-30(12-10-26(40)2)50(61)55-38-14-16-42(84(72,73)74)36-22-34(82(66,67)68)24-44(46(36)38)86(78,79)80/h3-24H,1-2H3,(H,54,60)(H,55,61)(H,56,58)(H,57,59)(H2,52,53,62)(H,63,64,65)(H,66,67,68)(H,69,70,71)(H,72,73,74)(H,75,76,77)(H,78,79,80) FIAFUQMPZJWCLV-UHFFFAOYSA-N 50336799 5,5',5''-[1,3,6-naphthalenetriyltris(sulfonylimino)]tris[1,3-benzenesulfonate analogue::8,8'-(Carbonylbis(imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino))bisnaphthalene-1,3,5-trisulphonic acid::8,8'-[CARBONYLBIS[IMINO-3,1-PHENYLENECARBONYLIMINO(4-METHYL-3,1-PHENYLENE)CARBONYLIMINO]]BIS-1,3,5-NAPHTHALENETRISULFONIC ACID::8,8'-[Carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonyl-imino]]bis-1,3,5-naphthalenetrisulfonic acid(suramin)::8-[(4-methyl-3-{[3-({[3-({2-methyl-5-[(4,6,8-trisulfonaphthalen-1-yl)carbamoyl]phenyl}carbamoyl)phenyl]carbamoyl}amino)benzene]amido}benzene)amido]naphthalene-1,3,5-trisulfonic acid::CHEMBL265502::Germanin::Suramin hexasodium::US8835659, Suramin::Urea derivative::suramin P2X purinoceptor 3 Homo sapiens 3000 ChEMBL 10.1021/jm020046y 10.7270/Q2VX0H71 12213051 Jacobson, KA; Jarvis, MF; Williams, M National Institute of Diabetes http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50336799 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50336799&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search SVR 2H9T,7YET,4YV5,4X3U,3BJW,7AH8,6Z7B,3PP7,1Y4L,3GAN,6CE2,4J4V,2NYR,3BF6,3UR0 5361 125086901 45906 CHEMBL265502 DB04786 1728 C07974 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 50203139 Nc1ncnc2n(cnc12)C1OC(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)C2OC3(OC12)C(=C[C-](C=C3[N+]([O-])=O)[N+]([O-])=O)[N+]([O-])=O InChI=1S/C16H16N8O19P3/c17-13-10-14(19-4-18-13)21(5-20-10)15-12-11(7(39-15)3-38-45(34,35)43-46(36,37)42-44(31,32)33)40-16(41-12)8(23(27)28)1-6(22(25)26)2-9(16)24(29)30/h1-2,4-5,7,11-12,15H,3H2,(H,34,35)(H,36,37)(H2,17,18,19)(H2,31,32,33)/q-1 SRBOSGVHTINDAV-UHFFFAOYSA-N 50370141 TNP-ATP P2X purinoceptor 3 Homo sapiens 15200 ChEMBL 10.1021/jm020046y 10.7270/Q2VX0H71 12213051 Jacobson, KA; Jarvis, MF; Williams, M National Institute of Diabetes http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50370141 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50370141&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 4468924 160849243 C03517 ZINC87515504 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 50203141 [O-]S(=O)(=O)c1cc(ccc1\C=C\c1ccc(cc1S([O-])(=O)=O)N=C=S)N=C=S InChI=1S/C16H10N2O6S4/c19-27(20,21)15-7-13(17-9-25)5-3-11(15)1-2-12-4-6-14(18-10-26)8-16(12)28(22,23)24/h1-8H,(H,19,20,21)(H,22,23,24)/p-2/b2-1+ YSCNMFDFYJUPEF-OWOJBTEDSA-L 50118214 CHEMBL133930::DIDS P2X purinoceptor 3 Homo sapiens >100000 ChEMBL 10.1021/jm020046y 10.7270/Q2VX0H71 12213051 Jacobson, KA; Jarvis, MF; Williams, M National Institute of Diabetes http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118214 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118214&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 6146472 104011551 CHEMBL133930 C11591 ZINC06844860 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 50203142 [O-]S(=O)(=O)c1cc(ccc1\C=C\c1ccc(cc1S([O-])(=O)=O)N=C=S)N=C=S InChI=1S/C16H10N2O6S4/c19-27(20,21)15-7-13(17-9-25)5-3-11(15)1-2-12-4-6-14(18-10-26)8-16(12)28(22,23)24/h1-8H,(H,19,20,21)(H,22,23,24)/p-2/b2-1+ YSCNMFDFYJUPEF-OWOJBTEDSA-L 50118214 CHEMBL133930::DIDS P2X purinoceptor 3 Homo sapiens 1000 ChEMBL 10.1021/jm020046y 10.7270/Q2VX0H71 12213051 Jacobson, KA; Jarvis, MF; Williams, M National Institute of Diabetes http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118214 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118214&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 6146472 104011551 CHEMBL133930 C11591 ZINC06844860 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 50203172 Cc1nc(N=Nc2ccc(cc2S(O)(=O)=O)S(O)(=O)=O)c(COP(O)(O)=O)c(C=O)c1O InChI=1S/C14H14N3O12PS2/c1-7-13(19)9(5-18)10(6-29-30(20,21)22)14(15-7)17-16-11-3-2-8(31(23,24)25)4-12(11)32(26,27)28/h2-5,19H,6H2,1H3,(H2,20,21,22)(H,23,24,25)(H,26,27,28) PNFZSRRRZNXSMF-UHFFFAOYSA-N 85043 CAS_149017-66-3::CHEMBL69234::NSC_6093163::PPADS P2X purinoceptor 3 Homo sapiens 240 ChEMBL 10.1021/jm020046y 10.7270/Q2VX0H71 12213051 Jacobson, KA; Jarvis, MF; Williams, M National Institute of Diabetes http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=85043 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=85043&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 5478935 136351143 CHEMBL69234 ZINC18247107 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 50310288 O[C@H]([C@H](CC1CCCCC1)NC(=O)[C@@H](Cc1cscn1)NC(=O)c1nc2ccccc2[nH]1)[C@@H](O)C1CC1 InChI=1S/C27H35N5O4S/c33-23(17-10-11-17)24(34)21(12-16-6-2-1-3-7-16)31-26(35)22(13-18-14-37-15-28-18)32-27(36)25-29-19-8-4-5-9-20(19)30-25/h4-5,8-9,14-17,21-24,33-34H,1-3,6-7,10-13H2,(H,29,30)(H,31,35)(H,32,36)/t21-,22+,23-,24+/m0/s1 JHRSGCIIDRWHCD-UARRHKHWSA-N 50168286 1H-Benzoimidazole-2-carboxylic acid [(R)-1-((1S,2R,3S)-1-cyclohexylmethyl-3-cyclopropyl-2,3-dihydroxy-propylcarbamoyl)-2-thiazol-4-yl-ethyl]-amide::CHEMBL190141 P2X purinoceptor 3 Homo sapiens >100000 ChEMBL 10.1016/j.bmcl.2005.04.049 10.7270/Q2GX4B38 15927468 Jaime-Figueroa, S; Greenhouse, R; Padilla, F; Dillon, MP; Gever, JR; Ford, AP Roche Palo Alto http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50168286 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50168286&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 11663667 104053278 CHEMBL190141 ZINC14209607 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 50809870 CNc1ncnc2n(cnc12)[C@H]1C[C@H](OP(O)(O)=O)[C@@H](COP(O)(O)=O)O1 InChI=1S/C11H17N5O9P2/c1-12-10-9-11(14-4-13-10)16(5-15-9)8-2-6(25-27(20,21)22)7(24-8)3-23-26(17,18)19/h4-8H,2-3H2,1H3,(H,12,13,14)(H2,17,18,19)(H2,20,21,22)/t6-,7+,8+/m0/s1 CCPLITQNIFLYQB-XLPZGREQSA-N 50118229 CHEMBL129841::MRS 2179 P2X purinoceptor 3 Homo sapiens 12900 ChEMBL 10.1021/jm0104062 10.7270/Q2ST7QK0 11831909 Raboisson, P; Baurand, A; Cazenave, JP; Gachet, C; Retat, M; Spiess, B; Bourguignon, JJ Universit£ Louis Pasteur http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118229 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118229&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 5311303 104011566 CHEMBL129841 ZINC03985980 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 50806920 O[C@@H]1[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)n2cnc3c2nc[nH]c3=O)O[C@H]([C@@H]1O)n1cnc2c1nc[nH]c2=O InChI=1S/C20H27N8O24P5/c29-11-7(47-19(13(11)31)27-5-25-9-15(27)21-3-23-17(9)33)1-45-53(35,36)49-55(39,40)51-57(43,44)52-56(41,42)50-54(37,38)46-2-8-12(30)14(32)20(48-8)28-6-26-10-16(28)22-4-24-18(10)34/h3-8,11-14,19-20,29-32H,1-2H2,(H,35,36)(H,37,38)(H,39,40)(H,41,42)(H,43,44)(H,21,23,33)(H,22,24,34)/t7-,8+,11-,12+,13-,14+,19-,20-/m1/s1 BSAJMNPXQBCFBF-PWENJLMOSA-N 50118215 CHEMBL1628528::Ip5I P2X purinoceptor 3 Homo sapiens 2800 ChEMBL 10.1021/jm020046y 10.7270/Q2VX0H71 12213051 Jacobson, KA; Jarvis, MF; Williams, M National Institute of Diabetes http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118215 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118215&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 9962943 104011552 CHEMBL1628528 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 50806922 [O-]S(=O)(=O)c1cc(ccc1\C=C\c1ccc(cc1S([O-])(=O)=O)N=C=S)N=C=S InChI=1S/C16H10N2O6S4/c19-27(20,21)15-7-13(17-9-25)5-3-11(15)1-2-12-4-6-14(18-10-26)8-16(12)28(22,23)24/h1-8H,(H,19,20,21)(H,22,23,24)/p-2/b2-1+ YSCNMFDFYJUPEF-OWOJBTEDSA-L 50118214 CHEMBL133930::DIDS P2X purinoceptor 3 Homo sapiens 11000 ChEMBL 10.1021/jm020046y 10.7270/Q2VX0H71 12213051 Jacobson, KA; Jarvis, MF; Williams, M National Institute of Diabetes http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118214 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118214&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 6146472 104011551 CHEMBL133930 C11591 ZINC06844860 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 50806930 Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1OC(=O)c1ccc(cc1)-c1ccccc1 InChI=1S/C23H24N5O14P3/c24-20-17-21(26-11-25-20)28(12-27-17)22-19(40-23(30)15-8-6-14(7-9-15)13-4-2-1-3-5-13)18(29)16(39-22)10-38-44(34,35)42-45(36,37)41-43(31,32)33/h1-9,11-12,16,18-19,22,29H,10H2,(H,34,35)(H,36,37)(H2,24,25,26)(H2,31,32,33)/t16-,18-,19-,22-/m1/s1 MUYAADFIZYSSNL-WGQQHEPDSA-N 50118219 Bz-ATP::CHEMBL339386 P2X purinoceptor 3 Homo sapiens 80 ChEMBL 10.1021/jm020046y 10.7270/Q2VX0H71 12213051 Jacobson, KA; Jarvis, MF; Williams, M National Institute of Diabetes http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118219 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118219&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 44353592 104011556 CHEMBL339386 C03517 ZINC49748211 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 50806943 Nc1ncnc2n(cnc12)C1OC(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)C2OC3(OC12)C(=C[C-](C=C3[N+]([O-])=O)[N+]([O-])=O)[N+]([O-])=O InChI=1S/C16H16N8O19P3/c17-13-10-14(19-4-18-13)21(5-20-10)15-12-11(7(39-15)3-38-45(34,35)43-46(36,37)42-44(31,32)33)40-16(41-12)8(23(27)28)1-6(22(25)26)2-9(16)24(29)30/h1-2,4-5,7,11-12,15H,3H2,(H,34,35)(H,36,37)(H2,17,18,19)(H2,31,32,33)/q-1 SRBOSGVHTINDAV-UHFFFAOYSA-N 50370141 TNP-ATP P2X purinoceptor 3 Homo sapiens 15200 ChEMBL 10.1021/jm020046y 10.7270/Q2VX0H71 12213051 Jacobson, KA; Jarvis, MF; Williams, M National Institute of Diabetes http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50370141 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50370141&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 4468924 160849243 C03517 ZINC87515504 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 50806955 CNc1ncnc2n(cnc12)[C@H]1C[C@H](OP(O)(O)=O)[C@@H](COP(O)(O)=O)O1 InChI=1S/C11H17N5O9P2/c1-12-10-9-11(14-4-13-10)16(5-15-9)8-2-6(25-27(20,21)22)7(24-8)3-23-26(17,18)19/h4-8H,2-3H2,1H3,(H,12,13,14)(H2,17,18,19)(H2,20,21,22)/t6-,7+,8+/m0/s1 CCPLITQNIFLYQB-XLPZGREQSA-N 50118229 CHEMBL129841::MRS 2179 P2X purinoceptor 3 Homo sapiens 13000 ChEMBL 10.1021/jm020046y 10.7270/Q2VX0H71 12213051 Jacobson, KA; Jarvis, MF; Williams, M National Institute of Diabetes http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118229 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118229&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 5311303 104011566 CHEMBL129841 ZINC03985980 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 50806963 CSc1nc(N)c2ncn([C@@H]3O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]3O)c2n1 InChI=1S/C11H18N5O13P3S/c1-33-11-14-8(12)5-9(15-11)16(3-13-5)10-7(18)6(17)4(27-10)2-26-31(22,23)29-32(24,25)28-30(19,20)21/h3-4,6-7,10,17-18H,2H2,1H3,(H,22,23)(H,24,25)(H2,12,14,15)(H2,19,20,21)/t4-,6-,7-,10-/m1/s1 XNOBOKJVOTYSJV-KQYNXXCUSA-N 50118232 2-MeSATP::ATP, 2-meS::CHEMBL336208 P2X purinoceptor 3 Homo sapiens 350 ChEMBL 10.1021/jm020046y 10.7270/Q2VX0H71 12213051 Jacobson, KA; Jarvis, MF; Williams, M National Institute of Diabetes http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118232 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118232&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 6AT 5SVP,5SVM,4PY0 5310983 104011569 CHEMBL336208 C03517 ZINC17654543 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 50806964 Nc1ccc(CCSc2nc(N)c3ncn([C@@H]4O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]4O)c3n2)cc1 InChI=1S/C18H25N6O13P3S/c19-10-3-1-9(2-4-10)5-6-41-18-22-15(20)12-16(23-18)24(8-21-12)17-14(26)13(25)11(35-17)7-34-39(30,31)37-40(32,33)36-38(27,28)29/h1-4,8,11,13-14,17,25-26H,5-7,19H2,(H,30,31)(H,32,33)(H2,20,22,23)(H2,27,28,29)/t11-,13-,14-,17-/m1/s1 IAEUEMYQURUPGA-LSCFUAHRSA-N 50118226 CHEMBL337062::PAPET-ATP P2X purinoceptor 3 Homo sapiens 17 ChEMBL 10.1021/jm020046y 10.7270/Q2VX0H71 12213051 Jacobson, KA; Jarvis, MF; Williams, M National Institute of Diabetes http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118226 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118226&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 5310950 104011563 CHEMBL337062 C03517 ZINC49739457 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 50806981 Cc1nc(N=Nc2ccc(cc2S(O)(=O)=O)S(O)(=O)=O)c(COP(O)(O)=O)c(C=O)c1O InChI=1S/C14H14N3O12PS2/c1-7-13(19)9(5-18)10(6-29-30(20,21)22)14(15-7)17-16-11-3-2-8(31(23,24)25)4-12(11)32(26,27)28/h2-5,19H,6H2,1H3,(H2,20,21,22)(H,23,24,25)(H,26,27,28) PNFZSRRRZNXSMF-UHFFFAOYSA-N 85043 CAS_149017-66-3::CHEMBL69234::NSC_6093163::PPADS P2X purinoceptor 3 Homo sapiens 1700 ChEMBL 10.1021/jm020046y 10.7270/Q2VX0H71 12213051 Jacobson, KA; Jarvis, MF; Williams, M National Institute of Diabetes http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=85043 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=85043&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 5478935 136351143 CHEMBL69234 ZINC18247107 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 50806990 Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)OP(O)(S)=O)[C@@H](O)[C@H]1O InChI=1S/C10H15N5O9P2S/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(23-10)1-22-25(18,19)24-26(20,21)27/h2-4,6-7,10,16-17H,1H2,(H,18,19)(H2,11,12,13)(H2,20,21,27)/t4-,6-,7-,10-/m1/s1 HCIKUKNAJRJFOW-KQYNXXCUSA-N 50118230 5'-O-[(R)-HYDROXY(THIOPHOSPHONOOXY)PHOSPHORYL]ADENOSINE::ADPbetaS::CHEMBL335206::adenosine-5'-O-beta-thiodiphosphate P2X purinoceptor 3 Homo sapiens 8800 ChEMBL 10.1021/jm020046y 10.7270/Q2VX0H71 12213051 Jacobson, KA; Jarvis, MF; Williams, M National Institute of Diabetes http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118230 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118230&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 5310996 104011567 CHEMBL335206 1755 C13743 ZINC16346988 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 50807024 Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O InChI=1S/C20H28N10O19P4/c21-15-9-17(25-3-23-15)29(5-27-9)19-13(33)11(31)7(45-19)1-43-50(35,36)47-52(39,40)49-53(41,42)48-51(37,38)44-2-8-12(32)14(34)20(46-8)30-6-28-10-16(22)24-4-26-18(10)30/h3-8,11-14,19-20,31-34H,1-2H2,(H,35,36)(H,37,38)(H,39,40)(H,41,42)(H2,21,23,25)(H2,22,24,26)/t7-,8-,11-,12-,13-,14-,19-,20-/m1/s1 YOAHKNVSNCMZGQ-XPWFQUROSA-N 50118220 (ppA)2::A(5')p4(5')A::CHEMBL339385::P(1),P(4)-bis(5'-adenosyl) tetraphosphate::adenosine(5')tetraphospho(5')adenosine::bis(5'-adenylyl) diphosphate P2X purinoceptor 3 Homo sapiens 500 ChEMBL 10.1021/jm020046y 10.7270/Q2VX0H71 12213051 Jacobson, KA; Jarvis, MF; Williams, M National Institute of Diabetes http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118220 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118220&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 21706 104011557 17422 CHEMBL339385 C01260 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 50807034 CCCCCCSc1nc(N)c2ncn([C@@H]3O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]3O)c2n1 InChI=1S/C16H26N5O7PS/c1-2-3-4-5-6-30-16-19-13(17)10-14(20-16)21(8-18-10)15-12(23)11(22)9(28-15)7-27-29(24,25)26/h8-9,11-12,15,22-23H,2-7H2,1H3,(H2,17,19,20)(H2,24,25,26)/t9-,11-,12-,15-/m1/s1 MSDFWMVEFNRURX-SDBHATRESA-N 50118240 ((2R,3S,4R,5R)-5-(6-amino-2-(hexylthio)-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate::CHEMBL130094::HT-AMP P2X purinoceptor 3 Homo sapiens 350 ChEMBL 10.1021/jm020046y 10.7270/Q2VX0H71 12213051 Jacobson, KA; Jarvis, MF; Williams, M National Institute of Diabetes http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118240 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118240&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 5310949 104011577 CHEMBL130094 ZINC13557426 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 50807040 Cc1ccc(cc1NC(=O)c1cccc(NC(=O)Nc2cccc(c2)C(=O)Nc2cc(ccc2C)C(=O)Nc2ccc(c3cc(cc(c23)S(O)(=O)=O)S(O)(=O)=O)S(O)(=O)=O)c1)C(=O)Nc1ccc(c2cc(cc(c12)S(O)(=O)=O)S(O)(=O)=O)S(O)(=O)=O InChI=1S/C51H40N6O23S6/c1-25-9-11-29(49(60)54-37-13-15-41(83(69,70)71)35-21-33(81(63,64)65)23-43(45(35)37)85(75,76)77)19-39(25)56-47(58)27-5-3-7-31(17-27)52-51(62)53-32-8-4-6-28(18-32)48(59)57-40-20-30(12-10-26(40)2)50(61)55-38-14-16-42(84(72,73)74)36-22-34(82(66,67)68)24-44(46(36)38)86(78,79)80/h3-24H,1-2H3,(H,54,60)(H,55,61)(H,56,58)(H,57,59)(H2,52,53,62)(H,63,64,65)(H,66,67,68)(H,69,70,71)(H,72,73,74)(H,75,76,77)(H,78,79,80) FIAFUQMPZJWCLV-UHFFFAOYSA-N 50336799 5,5',5''-[1,3,6-naphthalenetriyltris(sulfonylimino)]tris[1,3-benzenesulfonate analogue::8,8'-(Carbonylbis(imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino))bisnaphthalene-1,3,5-trisulphonic acid::8,8'-[CARBONYLBIS[IMINO-3,1-PHENYLENECARBONYLIMINO(4-METHYL-3,1-PHENYLENE)CARBONYLIMINO]]BIS-1,3,5-NAPHTHALENETRISULFONIC ACID::8,8'-[Carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonyl-imino]]bis-1,3,5-naphthalenetrisulfonic acid(suramin)::8-[(4-methyl-3-{[3-({[3-({2-methyl-5-[(4,6,8-trisulfonaphthalen-1-yl)carbamoyl]phenyl}carbamoyl)phenyl]carbamoyl}amino)benzene]amido}benzene)amido]naphthalene-1,3,5-trisulfonic acid::CHEMBL265502::Germanin::Suramin hexasodium::US8835659, Suramin::Urea derivative::suramin P2X purinoceptor 3 Homo sapiens 14900 ChEMBL 10.1021/jm020046y 10.7270/Q2VX0H71 12213051 Jacobson, KA; Jarvis, MF; Williams, M National Institute of Diabetes http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50336799 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50336799&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search SVR 2H9T,7YET,4YV5,4X3U,3BJW,7AH8,6Z7B,3PP7,1Y4L,3GAN,6CE2,4J4V,2NYR,3BF6,3UR0 5361 125086901 45906 CHEMBL265502 DB04786 1728 C07974 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 50807041 Cc1ncc2COP(O)(=O)OCc2c1O InChI=1S/C8H10NO5P/c1-5-8(10)7-4-14-15(11,12)13-3-6(7)2-9-5/h2,10H,3-4H2,1H3,(H,11,12) KCAJHODRYGNBSX-UHFFFAOYSA-N 50064803 3-Methyl-7-oxo-5,9-dihydro-6,8-dioxa-2-aza-7lambda*5*-phospha-benzocycloheptene-4,7-diol::CHEMBL74121::MRS 2220 P2X purinoceptor 3 Homo sapiens 58300 ChEMBL 10.1021/jm020046y 10.7270/Q2VX0H71 12213051 Jacobson, KA; Jarvis, MF; Williams, M National Institute of Diabetes http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50064803 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50064803&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 3960826 103959758 CHEMBL74121 6496 ZINC26376205 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 50807061 [O-]S(=O)(=O)c1cc(c2c(NC(=O)c3cccc(NC(=O)Nc4cccc(c4)C(=O)Nc4ccc(c5cc(cc(c45)S([O-])(=O)=O)S([O-])(=O)=O)S([O-])(=O)=O)c3)ccc(c2c1)S([O-])(=O)=O)S([O-])(=O)=O InChI=1S/C35H26N4O21S6/c40-33(38-25-7-9-27(63(49,50)51)23-13-21(61(43,44)45)15-29(31(23)25)65(55,56)57)17-3-1-5-19(11-17)36-35(42)37-20-6-2-4-18(12-20)34(41)39-26-8-10-28(64(52,53)54)24-14-22(62(46,47)48)16-30(32(24)26)66(58,59)60/h1-16H,(H,38,40)(H,39,41)(H2,36,37,42)(H,43,44,45)(H,46,47,48)(H,49,50,51)(H,52,53,54)(H,55,56,57)(H,58,59,60)/p-6 JMONOAYAUIIKMS-UHFFFAOYSA-H 50118228 5,7-Disulfo-4-(3-{3-[3-(4,6,8-trisulfo-naphthalen-1-ylcarbamoyl)-phenyl]-ureido}-benzoylamino)-naphthalene-1-sulfonic acid anion;hexasodium salt::CHEMBL216504::Urea derivative P2X purinoceptor 3 Homo sapiens 28500 ChEMBL 10.1021/jm020046y 10.7270/Q2VX0H71 12213051 Jacobson, KA; Jarvis, MF; Williams, M National Institute of Diabetes http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118228 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118228&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 3315620 104011565 CHEMBL216504 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 50807063 Nc1ncnc2n(cnc12)[C@@H]1O[C@H](CO[P@@](O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1 XTWYTFMLZFPYCI-KQYNXXCUSA-N 50368125 ADENOSINE DIPHOSPHATE::ADP P2X purinoceptor 3 Homo sapiens >100000 ChEMBL 10.1021/jm020046y 10.7270/Q2VX0H71 12213051 Jacobson, KA; Jarvis, MF; Williams, M National Institute of Diabetes http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50368125 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50368125&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search ADP 7X5B,7UT9,7X54,1Y63,8A2T,8A2S,8A2R,7LNX,7LNW,7LNU,7LNT,7LN3,7LN2,7LN1,7LN0,7LN6,7LN5,7LN4,1NG9,1NGD,1NGA,1NGB,1NGC,8EGL,3LTD,3LTB,3LT9,3LT8,1W9J,2ZDG,1W9L,2ZDH,2ZDY,4M15,1IHU,3QVH,3QVF,1G3Q,7SGZ,6JKM,2BU8,2BUP,6K91,2BUF,1NN3,1NN0,4Q4C,6DJN,4BG4,4BGB,4BGA,4BGD,4C12,4NST,1TZD,8AG6,3WXL,1H8H,1H8E,6Z9S,6Z9R,6Z9Q,6Z9P,7LW1,7WBU,1O6B,6I59,3O8N,6I5F,3O8L,7ZTD,3O8R,7RIG,7PMF,8BNS,4XHG,7ABR,3EHH,5KK8,1GKI,7R32,7R30,1W0J,1W0K,3PEY,3PEW,4ARK,5LIH,7A4V,1XMV,7VYS,1YYF,4JKY,4JKI,7JIJ,3H4M,7CRC,4B2Q,1DAM,1G8X,2W58,2W5A,3HBL,3HB9,3K60,3NWN,8DVS,3MBL,3MBI,1UJ2,8DVU,8DAR,4IX4,4IX6,7QV8,7QV9,1Q9S,5T5T,4F7W,4GYI,6FUA,6FUX,1E4E,8G1F,1MO3,7V2F,7V2K,7UKA,7V2R,6D3K,5HE9,5KPZ,7P2Y,7TTN,2PMK,5EC0,1VOM,4XWO,4XW6,2VHU,2VHJ,1QQN,3I33,2DWC,2DWO,2I5B,6NHK,1S4E,2V26,2V2Z,6MT9,3UNG,4V81,4V8R,1RRC,3U06,3DIN,5VZ0,7NPE,4PJM,3NBX,1OL5,1OL7,7D4I,7D4O,5WDE,5WDH,1JDB,1ZAR,3A5C,6ZQM,3RV4,7TTS,3TPT,3FMP,3FMO,7C1Y,1MP8,4Q47,6B5D,5Z3U,5Z3V,5Z3O,6ZO4,7ADD,7ADE,5ELZ,5O7D,4BZQ,4BQS,6NE3,1UC9,1L0O,6L5O,7PX9,1THN,4CJ7,7U9K,1REA,2C2A,5D4N,5D4W,6M5U,6M5V,4NL0,4NL4,7TNE,6VVO,6GFG,3G8C,3G8D,6GQ6,8E3H,7NGP,7NGF,7NGC,7NGA,7NGL,7QIN,7QIM,7KY9,7KYB,5AFU,7KSM,1ZTH,6HD3,6HD0,5GM6,5GME,7DUT,6RKE,7YZO,6FO1,6FOC,1X6V,3IIL,3IIJ,6Z9T,7V2D,5BVC,3L4I,4AM7,2OLC,2OLJ,3ZUH,1NMX,1NMY,3LJ0,1M34,1DFL,8BV0,2HYD,1GSA,2YZL,6KY4,3N83,4GP6,1RDQ,6K7K,6ZYW,6ZYY,6ZYI,4NYE,1SVL,1SVT,5I0I,2QC8,6IUG,6G2W,6G2V,6G2Z,6G2Y,6G2X,6G2J,3JA8,7VLR,6HQU,3JAH,3JAI,3JAG,3FI8,7RSI,7DHW,7ZTC,1Z59,1Z5C,1HPM,6QDJ,6EP2,6EP5,3C4N,7L1R,7L1Q,1N2C,4WW4,4WW0,4WW9,6N30,6OAX,6OAY,6OAB,6OAA,6OA9,4AX8,4AXE,7S61,7S67,1XW4,8CCN,6BIH,7VZ8,3BZ9,3BZ8,7U4T,3IO3,2X7C,2X7E,2X7D,5FL3,5FL7,3QUI,3GBJ,1KSF,6YA7,6YA8,4QOS,5TDF,1QVI,7M74,2IF8,6JJ8,6JJ9,2BTD,6LYM,6LYL,6LYO,6LYK,6LY8,3RER,3RES,6ZNX,1CE8,7TTT,3EH9,6F5D,6OPC,7UDT,7UDU,4GCZ,6IHK,1FNN,3EGI,7AI6,4TLA,2JI6,1O51,7DCP,1VRP,6RU8,6RU7,7ZBH,6N2Y,6CZD,7ZBG,3BF1,2D7D,2IUU,1S3S,1W7K,1W7J,1W78,3PFF,3PFI,4ASU,4AS7,5EVZ,1XJK,1XJQ,3ZOZ,7ZI4,6NR6,2CGL,2CGJ,7JGA,2X86,4JJZ,6T1Y,1XTJ,6C8Z,2W6E,6W17,6W1Z,7U8R,1CZ7,1CZA,1T36,1T3T,8AK3,2F43,4IY0,4IYN,7QUX,2QUR,1Q8Y,4GVY,4GVZ,4GVA,4GVJ,1E79,6FTX,2ZTS,2VAS,8G6P,1TF2,1MND,6CMZ,7UJ0,7UJX,7UJS,7UJP,7TTR,5UFU,7P3N,5KWA,2PL3,5Y5X,5Y5Z,1IQP,5E7P,6NON,6NO5,6NO1,6NO0,6NO3,6NO2,6KLL,6KLN,2V1U,2V1X,3UMM,6V6S,7WZ3,2X6T,6ITC,1U0J,1A9X,6KS6,8E9B,2GM1,7MDM,7MDO,3NCR,3UQD,2WW4,7D5T,2WWI,2WWF,7KW7,5WC2,3R5H,3H4S,1PKG,7DWR,6FAA,3TQC,2FSN,2FSI,7BT7,7BTE,7BTI,7ED9,7ED6,6EOF,6EOE,5TSG,5MOE,8DAV,6B4I,3EQI,3EQH,3EQG,5EOY,5EOX,7FID,7T6F,5LBA,4XCJ,4XCG,6PAM,7PT7,7PT6,1RPZ,6NDY,4CK6,4CK7,4CK5,1LKX,1RFU,2Y83,8DMY,5JRJ,5JR7,6GR2,6GR5,6GRG,4PFK,4PFO,4PFP,1OXU,3SJD,4YSJ,4YS0,4Z9M,3CF0,3CF1,3CF2,3CF3,8SBV,3RTD,6RJ4,3TLX,3KZB,7VW7,5ZI2,3FYH,3IHL,7W1T,7W1V,7W1Y,4ANJ,7W1O,7UTJ,7W0Y,1NNE,7O3W,7O3Z,7O3Y,7O3X,1BR4,1BR2,1BR1,6BS4,6BS3,4NU1,4XHP,4XH0,1DGK,7TUB,7NK7,1R7R,1IAH,7MHS,5YA2,4CVN,7T4H,3DKP,6JDB,6K0R,1LVG,1COW,5ERR,4NXW,4NXU,4IFW,7MU0,8DAS,8DAT,5DRK,7QO6,3J4K,3EC2,6IRO,1ZXN,6G30,6G3R,6G3S,6HPU,8AS8,1EA6,6XLH,1Z6T,7VZW,7VZV,6QEL,6QEM,2IOR,2IOP,2IOA,2IO8,2IO9,6N2I,4WTJ,6N2Z,4WTD,3CJO,5GSZ,4L78,4AY2,6OBY,3B1N,3B1P,1Y8O,2DCN,1NY6,1NY5,1NY3,3LV8,3LVV,7U35,6WQH,5FM7,4ETP,8B6F,4XIV,5YZG,1G18,2Y8Q,2Y8I,2Y8L,6JIM,6JIL,6ZME,6ZM2,3W0O,1F9V,1F9W,1F9T,1F9U,7QO5,7QO4,4IOL,4IOK,4YIX,3W0P,7DRP,3JUX,7K21,5A5F,7S9W,7S9V,8A2Z,8A2Y,8A2U,7F4Z,7F4X,5HLE,6D8C,8G1E,3OAA,3VPC,3VPB,5TTH,3ZL8,2NCD,7RDZ,7RDY,7RDX,4LV7,4LV5,4LV8,2CH6,6ACX,4V1T,3GVI,8H77,1QQM,1QQO,1X3M,6YUF,3U9Z,6W23,6W22,6W21,6W20,6W24,4FFP,6S85,7AI7,3NUA,1EHI,7UK7,3WO1,3WO0,8ATF,4IZ5,6UPW,6UPV,6UP4,6N9L,4F9A,5T3O,4F93,4F99,4GW2,4GW0,6X2F,7AOI,3FD6,1HW8,1HW9,5U3C,1HWL,1HWJ,1HWK,1HWI,3JXU,6OK2,2ECK,5OVO,7YLX,7YLY,7UIX,7UIW,7UIV,2UYT,2UYI,5UIE,5UIV,7SX8,2PO0,1UCN,2VF7,2VF8,3MFP,5EXT,2HMF,2HMV,4U0U,4U0S,7SQ0,3I12,3KIN,4A50,4A51,4A5Y,1VFX,8ET3,4D26,8ETR,1RL9,4EBU,1U3G,1U3F,6VOM,6VOL,6VOO,6VON,6VOI,6VOH,6VOK,6VOJ,6VOG,6VOF,3U60,2XZO,1JBP,3HWS,7LJF,7LJO,2WPD,7D63,6SZB,6SZA,4H7Q,5B7I,1PHP,7VAL,7VAW,6DZG,4XE8,3DSR,7PZC,4KIT,7FJP,4KI8,3LA6,5LU4,2ZWH,2O1V,2HV7,2HVD,7PUX,7U19,1YP4,1WB9,1WBD,1WBB,1WBP,3KB1,5X9U,4UQO,7P3W,1S5G,3A7J,7THV,7THJ,2XOC,4BUB,8E5L 6022 160847227 16761 C03517 ZINC67267160 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 50807080 Nc1ncnc2n(cnc12)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)CP(O)(O)=O)[C@@H](O)[C@H]1O InChI=1S/C11H18N5O12P3/c12-9-6-10(14-2-13-9)16(3-15-6)11-8(18)7(17)5(27-11)1-26-31(24,25)28-30(22,23)4-29(19,20)21/h2-3,5,7-8,11,17-18H,1,4H2,(H,22,23)(H,24,25)(H2,12,13,14)(H2,19,20,21)/t5-,7-,8-,11-/m1/s1 UFZTZBNSLXELAL-IOSLPCCCSA-N 50370142 CHEMBL133463 P2X purinoceptor 3 Homo sapiens 9200 ChEMBL 10.1021/jm020046y 10.7270/Q2VX0H71 12213051 Jacobson, KA; Jarvis, MF; Williams, M National Institute of Diabetes http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50370142 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50370142&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search ACP 6O61,5CA1,5CA0,1G3R,6K9V,2PZP,2PZR,1O6Y,6I5C,7DB9,7DBC,7DBB,7ZX2,3EHF,3EHJ,6Y6D,6LCR,6SES,1SAZ,7NNP,6QQN,4CVL,2HCB,2DWP,4ZHQ,7SSJ,7SSI,6PNX,5O7A,4U98,5C93,6S9E,6PH4,4AMF,3N8G,1I44,6K7I,6K7J,7K0T,7DP8,6XMQ,5NG0,5NG1,8A9T,8A9Z,3ZXT,6JJU,6U2G,6I2P,6RU6,4AYX,4AYT,5XLZ,5XLT,4A9X,3FGO,7JFR,5M8G,5M8D,6V6Q,5G15,5Z4U,5Z4P,5S5Q,5S5Y,5S5F,5S5I,4XC0,5YLJ,5YL4,5YL2,5X8C,4CK0,3TLM,4AN9,4AN2,2PZ5,6BS2,5LI9,1IA0,5OV7,8ASN,6EQ9,6EQO,6Y4N,6Y4M,4XIV,5YZ3,3C9T,6D88,1KOF,7RD8,4E09,4ZDK,3T10,5ZTF,5UGX,2Z09,5UI0,3R8F,1VFP,5J2U,1JBV,2PVY,5C3Z,4K33,7CLD,3LLA,2PUL,2PUN,6BR1,6BRY,6BRF,4XOU,1GQT,1GQY,5X40,6JCJ,5AUO,5AUP,1ZYU,5M7G,5M7E,1K3A,2X14,5FNV,8DIQ,3W34,4H1W,2J4J,3ZM7,8BDE,7WCF,3GQI,6LLE,5UHN,6KNZ,5IYZ,1LII,1LIJ,2PY3,7LC3,2A9Z,7LGJ,4LJ9,4LJ6,4LJA,6NNG,5LXT,5LXS,1TZ6,2AB8,2ABS,7WIZ,2BY4,6LZJ,4C5M,4C5N,2Q0B,4C3R,5JH7,5EZY,5JQG,7NNL,2VOR,4UEU,1RFT,6GZE,7KY8,7OH7,6X1C,6X1E,6X1F,4J95,4J97,4J96,4J99,4J98,5S63,5S61,5S66,5S67,5LA6,7CNO,2PWL,8D3W,5S64,5S65,5H74,7Z2N,3B9R,2OHF,5EG3,5OSK,4KFU,5XHC,5XAG,8BDF,4RVZ,5EPV,7WHW,4F1M,4F1O,5XP3,5S4W,5S4Q,5S4R,2DQS,6GJ4,6A8B,4E07,4ZI7,6LN5,6LN6,6LN7,3HXY,3HXX,6CI7,5F2R,4XZ3,7EN3,7Z2P,8A0L,2HS4,7DBD,5AR3,5JVD,7DAE,2PVF,5S4P,5S4S,4XLV,6LSN,6LSM,5KSD,1Z2P,1KF0,3GIE,3GIG,4ZOL,4F0F,5S62,5S60,4MNE,6QTN,5XAF,7CNM,7CQN,1E22,5ZXH,4I4T,2PKN,1I6I,4XF7,5LOV,2HRY,2C88,2C8K,7TDG,5NJH,7DSH,7DSI,7VPI,2R7K,4WZA,4WZB,8C0F,5H7O,6WK0,3W8R,7VMK,4ITL,4TV8,4TV9,3FBR,5S5W,5S5U,5S5S,5S5G,5S5E,5S5D,5S5C,5S5B,5S5O,5S5L,5S5H,5S52,5S51,5S59,5S58,4MO4,4MO5,6CPF,1KJI,7EXC,1U54,1T5S,7BSP,4I50,4I55,7EMJ,5IUK,5IUJ,5IUM,5IUL,4O4J,4O4I,4O4H,4S35,6FKJ,6FKL,3C9S,2ZJA,3CLY,7TDI,7TDH,7TDK,7TDJ,7X23,4X9L,6N47,4OAV,5SB6,5SB7,5SB4,5SB5,5SB3,5SB8,5SB9,5SBD,5SBE,5SBB,5SBC,5SBA,4TUY,5BMV,5S4V,5S4Z,7OGN,5JCB,5C8Y,3AR2,6FJF,6FJM,4MV8,4MV3,4MV4,7YAJ,7YAI,7YAH,4BEW,7KJA,7KJC,7E4Y,7E4Z,7E4P,7E4Q,7E4R,3A1E,3A1C,5XI5,5XI7,6E2U,6TNH,6AGK,6AGG,8AHM,7UMZ,7K0S,5S5J,6C83,7LZ7,7LZ8,6HEF,5OOW,3NL6,3NL5,5V60,4RH3,2ZSE,5S4T,5S4U,4UU1,7Z67,5S4X,5S4Y,5S4L,5S4M,5S4N,5S4O,4O2B,5C40,5C41,2Z7Q,6FII,6EG5,7YAG,7OXY,7CE6,7CE8,7CEK,3AF2,4UXX,4IAC,6RB2,1DAH,6O5M,1WTC,4MWD,5LYJ,5CB4,6F7C,5YLS,6GF3,6HXB,3JVV,6HX8,7DAF,7DAD,1I58,1I5A,2XE8,4C3P,5MF4,7Z7D,6S83,5S5V,5S5T,5S5R,5S5P,5S5Z,5S5X,5S5A,5S5N,5S5M,5S5K,5S57,5S56,5S55,5S54,5S53,5S50,1DAG,1GLL,7CDA,5X1S,4NH1,7L05,4ANB,5NFZ,7AU5 91532 160849244 40532 CHEMBL133463 C13741 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 50807105 Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)CP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O InChI=1S/C11H18N5O12P3/c12-9-6-10(14-2-13-9)16(3-15-6)11-8(18)7(17)5(27-11)1-26-29(19,20)4-30(21,22)28-31(23,24)25/h2-3,5,7-8,11,17-18H,1,4H2,(H,19,20)(H,21,22)(H2,12,13,14)(H2,23,24,25)/t5-,7-,8-,11-/m1/s1 CAWZRIXWFRFUQB-IOSLPCCCSA-N 50118221 9H-purine derivative::CHEMBL132722::DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER::alpha,beta-meATP P2X purinoceptor 3 Homo sapiens 740 ChEMBL 10.1021/jm020046y 10.7270/Q2VX0H71 12213051 Jacobson, KA; Jarvis, MF; Williams, M National Institute of Diabetes http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118221 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118221&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91557 104011558 35056 CHEMBL132722 4093 C13740 ZINC08295117 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 50807109 Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(S)=O)[C@@H](O)[C@H]1O InChI=1S/C10H16N5O12P3S/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(25-10)1-24-28(18,19)26-29(20,21)27-30(22,23)31/h2-4,6-7,10,16-17H,1H2,(H,18,19)(H,20,21)(H2,11,12,13)(H2,22,23,31)/t4-,6-,7-,10-/m1/s1 NLTUCYMLOPLUHL-KQYNXXCUSA-N 50118217 ADENOSINE-5'-DIPHOSPHATE MONOTHIOPHOSPHATE::ATP-gammaS::ATPgammaS::CHEMBL131890::PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER P2X purinoceptor 3 Homo sapiens 690 ChEMBL 10.1021/jm020046y 10.7270/Q2VX0H71 12213051 Jacobson, KA; Jarvis, MF; Williams, M National Institute of Diabetes http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118217 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118217&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search ATG 440317 104011554 CHEMBL131890 C01469 ZINC24424495 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 50807119 Nc1ncnc2n(cnc12)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@@](O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O InChI=1S/C10H16N5O13P3/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1 ZKHQWZAMYRWXGA-KQYNXXCUSA-N 50366480 ADENOSINE TRIPHOSPHATE::ATP P2X purinoceptor 3 Homo sapiens 340 ChEMBL 10.1021/jm020046y 10.7270/Q2VX0H71 12213051 Jacobson, KA; Jarvis, MF; Williams, M National Institute of Diabetes http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50366480 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50366480&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search ATP 7UT9,1Y64,7LNU,7LN3,7LN2,7LN1,7LN0,7LN6,7LN5,7LN4,1NGE,1NGF,1NGG,1NGH,3LTA,3LTC,2NPI,2ZDQ,7NHL,1GY3,6J18,6J17,1G3I,7SGL,2BU2,2Q7G,2BUP,3H8V,6GFA,7QI6,7QI4,1H8H,4AUI,1FMW,1XDP,7ZSE,3O8L,5HNV,7ABR,3EHG,1KAZ,1KAY,1KAX,7R31,7U6Y,6TAY,6TAX,6DDZ,1XMI,1XMJ,6E0O,4A8M,4A8F,4A8Y,4A8Q,4A8S,4A8W,7JIJ,7CRC,7EKL,8H99,7N30,7N31,6YWX,6YWY,6YWE,6YW6,6YW7,6YW5,4B2Q,2W5G,2W5I,3HBT,8DAR,3CQD,4QC2,1Q97,4GY2,6FU2,1E4G,3FFK,3JZM,4CI6,1MO8,4QNR,6D3S,6D3R,7P2E,7P2Y,7V2Z,5ECQ,5ECP,4XWO,4XW5,2VHT,2VHQ,6NHX,6NHZ,6KCL,6KCM,6KC0,7JM6,7JM7,6MT9,1U5R,1I7L,1OL6,6JRS,7D4O,7D4U,7T3U,1ZAO,1Q24,6ZQM,3A5N,1PJ4,7AI5,3TPQ,7C1Z,4Q4Z,1B0U,7OQH,7LJ1,6P8J,3DGO,6ZO4,5FV0,6L59,6L57,4X6R,3R1R,7PX9,7U9X,7WTD,7WTE,7U9T,7U9K,2BBT,2BBS,2BBO,6ZTQ,4O0M,6GFH,1JKN,7NGF,7MJP,7MJQ,7MJO,1UF9,5AFU,7KSM,6UDQ,6RKE,6RKD,6RKA,7VVY,7VVZ,1KVK,4H4K,7OZ1,2OLQ,2OLR,7UUX,1NMD,1NM1,3Q60,7OIK,3BG5,3E1Y,7CGN,4GP7,1RDQ,2Q97,6ZYW,6ZYY,7W79,4DX2,3WVL,1SVM,3WV9,4DXL,6Z3R,6IUB,6IUC,5N9X,1HLU,7VLR,3JAY,6QRI,6QDV,3V2U,7AT1,7L1R,7L1S,7L1Q,6S47,6N30,7AM2,6OA9,7YFP,7YFN,7S61,7S67,7Y38,7RFH,7RFE,7RFG,6O75,6O78,1P8Z,6PTN,6PTO,7WPM,5FL7,3QUO,3QUN,4AZW,6YAR,6YAY,1G21,7EV2,7EV3,7M74,2BTF,3REP,3REU,8FHN,8FHO,7AIR,7AIQ,7AIP,3W1G,4TL7,1HCK,6HZM,7DC8,7RNR,4WTV,1AQ2,6N2Y,1NSF,1NSY,2CG9,7JGR,7JGA,5CYR,1YXQ,7FDV,7WAJ,6AB0,6AB2,6AB8,6ABK,3H5N,6YT3,6W18,6W17,6W1Z,7NZ0,7NZ3,1UEV,3T0Z,2F43,2QUI,7ZH9,8BI0,1E79,5U03,4TQD,7PO3,7RES,6CMW,2Z1U,7UJP,7UJT,7P3F,7P3N,4WAE,1TFW,1A0I,1DEJ,4M3Y,4XVU,6NOO,6NOP,6NO7,3UMP,3UMO,5J1T,8ESC,4EAJ,4EAK,4EAH,4EAG,7RAV,3G6V,6KSH,8E9B,1R9T,7MD2,6AEC,3NCQ,3MN6,3MN7,3MN5,3MN9,3UQE,3UQD,5WC0,6SYT,5WCB,4H0T,4H0V,4H0X,4H0Y,4H03,1PK8,7WYX,2FSG,7BT2,7WPT,7WPX,7WPN,7WPL,8DAV,3EQB,8CVT,4KH0,2PAV,2PAA,5EOU,5OTR,2O0H,6PAO,6PAN,6PAQ,5XVU,5FWP,5FWK,5FWL,5FWM,7CM9,7K3Z,4UP9,1TID,7Z5J,1RFQ,6ZSP,5JRJ,5LVP,5D15,6GRG,7MI6,7MI3,3SJH,2AQX,4Z94,6RJ4,3TLX,4O4F,4O4E,4O4D,7W1Y,4AN3,4KGM,4KGV,2PZE,2PZF,2PZG,3Q53,3LKI,3LKK,6PZ9,4XHO,6PZA,6PZI,7NK7,7CFI,3QO3,3QO7,7NZM,7EER,5YA1,6JD4,6JD5,5IE2,6ZXF,6ZXG,6ZXH,8DAS,8DAT,1SU2,3WQU,7QBA,5DRD,5DR2,7QO6,2R9V,4FO0,7V00,6N2Z,4FWM,1Y8R,1Y8P,1Y8Q,7KO2,7LHT,7LHW,1NYR,6BHU,6TQE,4M3T,4M3U,4M3W,4M3R,4M3X,4M3Z,2P55,1IJJ,5YZG,6JIU,6JIY,6JII,6JI0,6ZM6,6ZM5,5O5W,1F9A,8AAZ,4DLK,7QO5,7QO4,7B93,7M6L,7PW7,7M6A,7DYI,7DYE,7K2T,3C9R,1MDU,1KO5,3PGK,4AT8,4AT1,1XKV,8G8F,5XMI,5XMK,1Z0S,7VX8,7N1P,1RYR,1RYS,4FF3,6W23,6W22,6W21,6W20,6W24,4FFR,5VQA,4BJR,8DGC,4F93,6X2N,5ZTB,7R8E,7XA9,3FDX,1MIW,2Z08,2Z02,6CN2,7UIR,7P48,4KR7,3PJR,7PJI,2HMP,2HMU,2HMW,5EXY,4U07,4U0M,1WUA,7SHM,5ECK,5ECI,5ECH,5ECN,7Q6I,5LIL,7Q6F,7Q6D,3ULE,4KB6,7RGQ,6VOM,6VOL,6VOO,6VON,6VOI,6VOH,6VOK,6VOJ,6VOG,6VOF,3DKC,2GNK,3MMV,7LJF,2WPD,5V2L,5XZ9,1PHK,6O1V,7VAL,8A5P,8A5Q,1QZ5,1QZ6,3EPS,5LUH,4XBR,7PUP,7PUB,1YP3,6MAT,5X9G,5X9H,7P3W,8EOP,1LHR,1RGI,6ZR2,7WIT,3A7H,1L2T,6VTD,6VTB,7TVE,5I9E,4DQW,3CI1,3CI5,3CI4,3CIP,3CIS,6AH5,6AH4,2A84,7RZY,6RIS,6RIQ,4ZS4,2IA6,2IAJ,3ZS7,3LL3,4M9Z,4M9X,4M9Y,4M9S,7T0V,5LVO,8BX8,1MB9,2YXU,3QNO,3AB8,7ESB,2Y27,6JCU,2C01,7TCH,2C96,6Z1P,6R4S,7KL1,1ZYD,7PLJ,3M9O,4RTF,2XCW,3V01,3V04,2R86,2ILY,1N48,7W3M,7W3B,7LI3,7LI4,3Q9L,1R8B,5DK4,7U2X,2X15,5I4N,4P33,5YUD,6JH6,6JH8,6JH9,6U0M,8DGF,6IFR,2FGH,3W3D,7RL0,1ASZ,6CTA,3IQ0,4WH3,5GQL,5GQJ,8BD6,8BD4,8BD5,6TE0,4V02,4V0U,3GQK,1FQ1,6HBU,3QX9,3QXC,1U9I,5CSH,4TU0,2W00,2W02,3U8X,4ZGN,7NXV,2FF3,7K58,5T0G,5T0C,5T0J,5T0I,4GT3,7K5B,6FZB,4RQV,5ZUA,5U2H,7WIW,6RDW,7OIM,5A9P,1B8A,5A99,5A98,3X2W,3X2V,3X2U,6COM,7P5Z,7P52,7P50,2PNN,4XTR,4U1R,7ZZ3,7ZZ4,4A6X,4CBX,4CBU,4CBW,4CB0,3UC5,8FZQ,7D7Y,2RSF,6P8V,5KOY,6P80,3FPB,6EMA,2EWW,4G5Y,7ORJ,7ORK,7ORN,1B38,1B39,5Z68,5Z6R,7SXO,2PC9,7UO7,7PVN,1V1B,5L9N,3KE5,3KEU,4FXF,7NJL,7NJO,7NJN,7NJK,7NJQ,7NJS,6ZQN,5XJC,3DGL,2QKM,2QK4,2GBL,3SL2,6FML,7KZU,7KZI,5ACK,3CHW,5MWL,5MW8,5H67,5GJC,8BWY,3M3N,4HUT,7RCK,2ZHZ,7PSA,6WA8,6OIF,2OOY,4M63,7LG5,7LGQ,7LGM,6TDU,6TDY,3LMI,7JPS,7JPR,7JPQ,7JPP,7JPO,7JPN,6AWH,6AWG,4JYZ,5LXQ,6YII,6MM2,4CT2,4CT1,7T65,4CTA,6JBJ,6JBK,6JBD,3QB0,7Z3O,4IFE,3J2T,6IP2,7N74,5SVK,2A42,2A41,2A40,5OBJ,5NBN,5NBM,5NBL,1AYL,7VX0,7N6I,1KXP,1N5I,1N56,6N0T,7LJL,1V3S,7U1E,7U1S,7U1Q,2X0Q,3U9D,6AZ0,5CE3,1TQP,8APF,6JWY,6JWQ,6JWS,6JWT,6JWW,6JWV,5D4C,2XSZ,6U1D,6U1E,6U1F 5957 160845582 15422 C03517 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 50807036 Cc1nc(N=Nc2cc(ccc2S(O)(=O)=O)S(O)(=O)=O)c(COP(O)(O)=O)c(C=O)c1O InChI=1S/C14H14N3O12PS2/c1-7-13(19)9(5-18)10(6-29-30(20,21)22)14(15-7)17-16-11-4-8(31(23,24)25)2-3-12(11)32(26,27)28/h2-5,19H,6H2,1H3,(H2,20,21,22)(H,23,24,25)(H,26,27,28) XYBQYEJAMIDMPT-UHFFFAOYSA-N 50064800 2-(4-Formyl-5-hydroxy-6-methyl-3-phosphonooxymethyl-pyridin-2-ylazo)-benzene-1,4-disulfonic acid::CHEMBL69727::isoPPADS::pyridoxal-alpha5-phosphate-6-azophenyl-2',5'-disulfonic acid P2X purinoceptor 3 Homo sapiens 84 ChEMBL 10.1021/jm020046y 10.7270/Q2VX0H71 12213051 Jacobson, KA; Jarvis, MF; Williams, M National Institute of Diabetes http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50064800 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50064800&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 5975975 103959755 CHEMBL69727 ZINC03995672 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 50848113 Cc1nc(N=Nc2cc(ccc2S(O)(=O)=O)S(O)(=O)=O)c(COP(O)(O)=O)c(C=O)c1O InChI=1S/C14H14N3O12PS2/c1-7-13(19)9(5-18)10(6-29-30(20,21)22)14(15-7)17-16-11-4-8(31(23,24)25)2-3-12(11)32(26,27)28/h2-5,19H,6H2,1H3,(H2,20,21,22)(H,23,24,25)(H,26,27,28) XYBQYEJAMIDMPT-UHFFFAOYSA-N 50064800 2-(4-Formyl-5-hydroxy-6-methyl-3-phosphonooxymethyl-pyridin-2-ylazo)-benzene-1,4-disulfonic acid::CHEMBL69727::isoPPADS::pyridoxal-alpha5-phosphate-6-azophenyl-2',5'-disulfonic acid P2X purinoceptor 3 Homo sapiens 108 ChEMBL 10.1021/jm070114m 10.7270/Q25X29QC 17676725 Jung, KY; Moon, HD; Lee, GE; Lim, HH; Park, CS; Kim, YC Institute of Science and Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50064800 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50064800&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 5975975 103959755 CHEMBL69727 ZINC03995672 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 50848114 CC(C)C[C@H](N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]([C@@H](C)O)C(O)=O InChI=1S/C45H64N8O10/c1-23(2)19-31(46)39(56)50-37(25(5)6)43(60)51-36(24(3)4)42(59)49-34(20-27-14-16-29(55)17-15-27)44(61)53-18-10-13-35(53)41(58)48-33(40(57)52-38(26(7)54)45(62)63)21-28-22-47-32-12-9-8-11-30(28)32/h8-9,11-12,14-17,22-26,31,33-38,47,54-55H,10,13,18-21,46H2,1-7H3,(H,48,58)(H,49,59)(H,50,56)(H,51,60)(H,52,57)(H,62,63)/t26-,31+,33+,34+,35+,36+,37+,38+/m1/s1 BXIFNVGZIMFBQB-DYDSHOKNSA-N 50219120 CHEMBL395493::LVVYPWT P2X purinoceptor 3 Homo sapiens 0.0083 ChEMBL 10.1021/jm070114m 10.7270/Q25X29QC 17676725 Jung, KY; Moon, HD; Lee, GE; Lim, HH; Park, CS; Kim, YC Institute of Science and Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50219120 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50219120&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 3081832 104092490 CHEMBL395493 1026 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 50848115 CC(C)[C@H](NC(=O)[C@H](C)N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]([C@@H](C)O)C(O)=O InChI=1S/C42H58N8O10/c1-21(2)33(48-40(57)34(22(3)4)47-36(53)23(5)43)39(56)46-31(18-25-13-15-27(52)16-14-25)41(58)50-17-9-12-32(50)38(55)45-30(37(54)49-35(24(6)51)42(59)60)19-26-20-44-29-11-8-7-10-28(26)29/h7-8,10-11,13-16,20-24,30-35,44,51-52H,9,12,17-19,43H2,1-6H3,(H,45,55)(H,46,56)(H,47,53)(H,48,57)(H,49,54)(H,59,60)/t23-,24+,30-,31-,32-,33-,34-,35-/m0/s1 JZZWLFSCHMSJQR-XXWLAZNXSA-N 50219121 AVVYPWT::CHEMBL238310 P2X purinoceptor 3 Homo sapiens 14.3 ChEMBL 10.1021/jm070114m 10.7270/Q25X29QC 17676725 Jung, KY; Moon, HD; Lee, GE; Lim, HH; Park, CS; Kim, YC Institute of Science and Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50219121 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50219121&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 25054398 104092491 CHEMBL238310 C03803 ZINC95607454 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 50848116 CC(C)C[C@@H]1NC(=O)[C@@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)C(C)C)C(C)C)[C@@H](C)O InChI=1S/C45H62N8O9/c1-23(2)19-32-39(56)50-37(25(5)6)43(60)51-36(24(3)4)42(59)49-34(20-27-14-16-29(55)17-15-27)45(62)53-18-10-13-35(53)41(58)47-33(40(57)52-38(26(7)54)44(61)48-32)21-28-22-46-31-12-9-8-11-30(28)31/h8-9,11-12,14-17,22-26,32-38,46,54-55H,10,13,18-21H2,1-7H3,(H,47,58)(H,48,61)(H,49,59)(H,50,56)(H,51,60)(H,52,57)/t26-,32+,33+,34+,35+,36+,37+,38+/m1/s1 COEPOBZXGUREGL-BYZYSQTKSA-N 50219122 CHEMBL397926::cyclic LVVYPWT P2X purinoceptor 3 Homo sapiens 82.4 ChEMBL 10.1021/jm070114m 10.7270/Q25X29QC 17676725 Jung, KY; Moon, HD; Lee, GE; Lim, HH; Park, CS; Kim, YC Institute of Science and Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50219122 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50219122&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 17756317 104092492 CHEMBL397926 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 50848117 CC(C)C[C@H](N)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]([C@@H](C)O)C(O)=O InChI=1S/C43H60N8O10/c1-22(2)18-30(44)38(55)46-24(5)37(54)49-35(23(3)4)41(58)48-33(19-26-13-15-28(53)16-14-26)42(59)51-17-9-12-34(51)40(57)47-32(39(56)50-36(25(6)52)43(60)61)20-27-21-45-31-11-8-7-10-29(27)31/h7-8,10-11,13-16,21-25,30,32-36,45,52-53H,9,12,17-20,44H2,1-6H3,(H,46,55)(H,47,57)(H,48,58)(H,49,54)(H,50,56)(H,60,61)/t24-,25+,30-,32-,33-,34-,35-,36-/m0/s1 HOZWDBPFSGBJBM-DTSDQQARSA-N 50219123 CHEMBL395723::LAVYPWT P2X purinoceptor 3 Homo sapiens 32.4 ChEMBL 10.1021/jm070114m 10.7270/Q25X29QC 17676725 Jung, KY; Moon, HD; Lee, GE; Lim, HH; Park, CS; Kim, YC Institute of Science and Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50219123 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50219123&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 25054651 104092493 CHEMBL395723 ZINC95613148 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 50848118 CC(C)C[C@H](N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]([C@@H](C)O)C(O)=O InChI=1S/C45H64N8O10/c1-23(2)19-31(46)39(56)50-37(25(5)6)43(60)51-36(24(3)4)42(59)49-34(20-27-14-16-29(55)17-15-27)44(61)53-18-10-13-35(53)41(58)48-33(40(57)52-38(26(7)54)45(62)63)21-28-22-47-32-12-9-8-11-30(28)32/h8-9,11-12,14-17,22-26,31,33-38,47,54-55H,10,13,18-21,46H2,1-7H3,(H,48,58)(H,49,59)(H,50,56)(H,51,60)(H,52,57)(H,62,63)/t26-,31+,33+,34+,35+,36+,37+,38+/m1/s1 BXIFNVGZIMFBQB-DYDSHOKNSA-N 50219120 CHEMBL395493::LVVYPWT P2X purinoceptor 3 Homo sapiens 0.04810 ChEMBL 10.1021/jm070114m 10.7270/Q25X29QC 17676725 Jung, KY; Moon, HD; Lee, GE; Lim, HH; Park, CS; Kim, YC Institute of Science and Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50219120 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50219120&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 3081832 104092490 CHEMBL395493 1026 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 50858361 COc1cc(NC(=O)c2ccc(o2)-c2ccc(Cl)cc2)cc(OC)c1 InChI=1S/C19H16ClNO4/c1-23-15-9-14(10-16(11-15)24-2)21-19(22)18-8-7-17(25-18)12-3-5-13(20)6-4-12/h3-11H,1-2H3,(H,21,22) VHKBTPQDHDSBSP-UHFFFAOYSA-N 50212239 5-(4-chlorophenyl)-N-(3,5-dimethoxyphenyl)furan-2-carboxamide::A-803467::CHEMBL250699 P2X purinoceptor 3 Homo sapiens >10000 ChEMBL 10.1073/pnas.0611364104 10.7270/Q2J10411 17483457 Jarvis, MF; Honore, P; Shieh, CC; Chapman, M; Joshi, S; Zhang, XF; Kort, M; Carroll, W; Marron, B; Atkinson, R; Thomas, J; Liu, D; Krambis, M; Liu, Y; McGaraughty, S; Chu, K; Roeloffs, R; Zhong, C; Mikusa, JP; Hernandez, G; Gauvin, D; Wade, C; Zhu, C; Pai, M; Scanio, M; Shi, L; Drizin, I; Gregg, R; Matulenko, M; Hakeem, A; Gross, M; Johnson, M; Marsh, K; Wagoner, PK; Sullivan, JP; Faltynek, CR; Krafte, DS Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50212239 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50212239&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 95T 7WFR,7WE4,7WEL 16038374 104088220 CHEMBL250699 5734 ZINC14982453 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 50926108 CC(C)N1Cc2c(nc(nc2NCc2ccc(Cl)cc2)N2CCN(CC2)C(C)=O)C1=O InChI=1S/C22H27ClN6O2/c1-14(2)29-13-18-19(21(29)31)25-22(28-10-8-27(9-11-28)15(3)30)26-20(18)24-12-16-4-6-17(23)7-5-16/h4-7,14H,8-13H2,1-3H3,(H,24,25,26) ZLRNQUFXMFIXFC-UHFFFAOYSA-N 50379705 CHEMBL2011113 P2X purinoceptor 3 Homo sapiens 4214 ChEMBL 10.1016/j.bmcl.2012.01.124 10.7270/Q29W0GGF 22370269 Cantin, LD; Bayrakdarian, M; Buon, C; Grazzini, E; Hu, YJ; Labrecque, J; Leung, C; Luo, X; Martino, G; Pare, M; Payza, K; Popovic, N; Projean, D; Santhakumar, V; Walpole, C; Yu, XH; Tomaszewski, MJ AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50379705 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50379705&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 25117985 160858788 CHEMBL2011113 ZINC84605012 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 50926111 COCCNc1nc2C(=O)N(Cc2c(NC(c2ccccc2)c2ccccc2)n1)C(C)C InChI=1S/C25H29N5O2/c1-17(2)30-16-20-22(24(30)31)28-25(26-14-15-32-3)29-23(20)27-21(18-10-6-4-7-11-18)19-12-8-5-9-13-19/h4-13,17,21H,14-16H2,1-3H3,(H2,26,27,28,29) PFVPOXPBICGXPQ-UHFFFAOYSA-N 50379708 CHEMBL2010931 P2X purinoceptor 3 Homo sapiens 255 ChEMBL 10.1016/j.bmcl.2012.01.124 10.7270/Q29W0GGF 22370269 Cantin, LD; Bayrakdarian, M; Buon, C; Grazzini, E; Hu, YJ; Labrecque, J; Leung, C; Luo, X; Martino, G; Pare, M; Payza, K; Popovic, N; Projean, D; Santhakumar, V; Walpole, C; Yu, XH; Tomaszewski, MJ AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50379708 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50379708&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 57480939 160858791 CHEMBL2010931 ZINC84633349 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 50926112 CC(C)N1Cc2c(nc(nc2N[C@H](C)c2ccc(C)cc2)N2CCN(CC2)C(C)=O)C1=O InChI=1S/C24H32N6O2/c1-15(2)30-14-20-21(23(30)32)26-24(29-12-10-28(11-13-29)18(5)31)27-22(20)25-17(4)19-8-6-16(3)7-9-19/h6-9,15,17H,10-14H2,1-5H3,(H,25,26,27)/t17-/m1/s1 QVAQKJNZIKLRTI-QGZVFWFLSA-N 50379709 CHEMBL2011117 P2X purinoceptor 3 Homo sapiens 613 ChEMBL 10.1016/j.bmcl.2012.01.124 10.7270/Q29W0GGF 22370269 Cantin, LD; Bayrakdarian, M; Buon, C; Grazzini, E; Hu, YJ; Labrecque, J; Leung, C; Luo, X; Martino, G; Pare, M; Payza, K; Popovic, N; Projean, D; Santhakumar, V; Walpole, C; Yu, XH; Tomaszewski, MJ AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50379709 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50379709&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 25121856 160858792 CHEMBL2011117 ZINC84633400 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 50926113 COc1ccc(cc1)[C@@H](C)Nc1nc(nc2C(=O)N(Cc12)C(C)C)N1CCN(CC1)C(C)=O InChI=1S/C24H32N6O3/c1-15(2)30-14-20-21(23(30)32)26-24(29-12-10-28(11-13-29)17(4)31)27-22(20)25-16(3)18-6-8-19(33-5)9-7-18/h6-9,15-16H,10-14H2,1-5H3,(H,25,26,27)/t16-/m1/s1 DOLIQXUWTQNSNR-MRXNPFEDSA-N 50379710 CHEMBL2011119 P2X purinoceptor 3 Homo sapiens 2523 ChEMBL 10.1016/j.bmcl.2012.01.124 10.7270/Q29W0GGF 22370269 Cantin, LD; Bayrakdarian, M; Buon, C; Grazzini, E; Hu, YJ; Labrecque, J; Leung, C; Luo, X; Martino, G; Pare, M; Payza, K; Popovic, N; Projean, D; Santhakumar, V; Walpole, C; Yu, XH; Tomaszewski, MJ AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50379710 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50379710&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 57431767 160858793 CHEMBL2011119 ZINC84633916 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 50926114 CCOc1ccc(cc1)[C@@H](C)Nc1nc(nc2C(=O)N(Cc12)C(C)C)N1CCN(CC1)C(C)=O InChI=1S/C25H34N6O3/c1-6-34-20-9-7-19(8-10-20)17(4)26-23-21-15-31(16(2)3)24(33)22(21)27-25(28-23)30-13-11-29(12-14-30)18(5)32/h7-10,16-17H,6,11-15H2,1-5H3,(H,26,27,28)/t17-/m1/s1 VIPPQTHWLREBCT-QGZVFWFLSA-N 50379711 CHEMBL2011120 P2X purinoceptor 3 Homo sapiens 69 ChEMBL 10.1016/j.bmcl.2012.01.124 10.7270/Q29W0GGF 22370269 Cantin, LD; Bayrakdarian, M; Buon, C; Grazzini, E; Hu, YJ; Labrecque, J; Leung, C; Luo, X; Martino, G; Pare, M; Payza, K; Popovic, N; Projean, D; Santhakumar, V; Walpole, C; Yu, XH; Tomaszewski, MJ AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50379711 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50379711&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 25118338 160858794 CHEMBL2011120 ZINC68247087 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 50926115 CCOc1ccc(cc1)[C@@H](CC)Nc1nc(nc2C(=O)N(Cc12)C(C)C)N1CCN(CC1)C(C)=O InChI=1S/C26H36N6O3/c1-6-22(19-8-10-20(11-9-19)35-7-2)27-24-21-16-32(17(3)4)25(34)23(21)28-26(29-24)31-14-12-30(13-15-31)18(5)33/h8-11,17,22H,6-7,12-16H2,1-5H3,(H,27,28,29)/t22-/m1/s1 PQCXBWVDXCTDMT-JOCHJYFZSA-N 50379712 CHEMBL2011121 P2X purinoceptor 3 Homo sapiens 212 ChEMBL 10.1016/j.bmcl.2012.01.124 10.7270/Q29W0GGF 22370269 Cantin, LD; Bayrakdarian, M; Buon, C; Grazzini, E; Hu, YJ; Labrecque, J; Leung, C; Luo, X; Martino, G; Pare, M; Payza, K; Popovic, N; Projean, D; Santhakumar, V; Walpole, C; Yu, XH; Tomaszewski, MJ AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50379712 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50379712&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 57658971 160858795 CHEMBL2011121 ZINC84615659 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 50926116 CCOc1ccc(cc1)[C@H](Nc1nc(nc2C(=O)N(Cc12)C(C)C)N1CCN(CC1)C(C)=O)C(F)(F)F InChI=1S/C25H31F3N6O3/c1-5-37-18-8-6-17(7-9-18)21(25(26,27)28)30-22-19-14-34(15(2)3)23(36)20(19)29-24(31-22)33-12-10-32(11-13-33)16(4)35/h6-9,15,21H,5,10-14H2,1-4H3,(H,29,30,31)/t21-/m0/s1 TWODWTDFVUUPMQ-NRFANRHFSA-N 50379713 CHEMBL2011122 P2X purinoceptor 3 Homo sapiens 115 ChEMBL 10.1016/j.bmcl.2012.01.124 10.7270/Q29W0GGF 22370269 Cantin, LD; Bayrakdarian, M; Buon, C; Grazzini, E; Hu, YJ; Labrecque, J; Leung, C; Luo, X; Martino, G; Pare, M; Payza, K; Popovic, N; Projean, D; Santhakumar, V; Walpole, C; Yu, XH; Tomaszewski, MJ AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50379713 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50379713&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 57658935 160858796 CHEMBL2011122 ZINC84619266 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 50926117 CCOc1ccc(cc1F)[C@@H](C)Nc1nc(nc2C(=O)N(Cc12)C(C)C)N1CCN(CC1)C(C)=O InChI=1S/C25H33FN6O3/c1-6-35-21-8-7-18(13-20(21)26)16(4)27-23-19-14-32(15(2)3)24(34)22(19)28-25(29-23)31-11-9-30(10-12-31)17(5)33/h7-8,13,15-16H,6,9-12,14H2,1-5H3,(H,27,28,29)/t16-/m1/s1 UWGMYBLNCMZZFK-MRXNPFEDSA-N 50379714 CHEMBL2011123 P2X purinoceptor 3 Homo sapiens 38 ChEMBL 10.1016/j.bmcl.2012.01.124 10.7270/Q29W0GGF 22370269 Cantin, LD; Bayrakdarian, M; Buon, C; Grazzini, E; Hu, YJ; Labrecque, J; Leung, C; Luo, X; Martino, G; Pare, M; Payza, K; Popovic, N; Projean, D; Santhakumar, V; Walpole, C; Yu, XH; Tomaszewski, MJ AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50379714 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50379714&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 57658880 160858797 CHEMBL2011123 ZINC84619268 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 50926118 CCOc1ncc(cc1F)[C@@H](C)Nc1nc(nc2C(=O)N(Cc12)C(C)C)N1CCN(CC1)C(C)=O InChI=1S/C24H32FN7O3/c1-6-35-22-19(25)11-17(12-26-22)15(4)27-21-18-13-32(14(2)3)23(34)20(18)28-24(29-21)31-9-7-30(8-10-31)16(5)33/h11-12,14-15H,6-10,13H2,1-5H3,(H,27,28,29)/t15-/m1/s1 LBGUGHRCONFPLR-OAHLLOKOSA-N 50379715 CHEMBL2011124 P2X purinoceptor 3 Homo sapiens 521 ChEMBL 10.1016/j.bmcl.2012.01.124 10.7270/Q29W0GGF 22370269 Cantin, LD; Bayrakdarian, M; Buon, C; Grazzini, E; Hu, YJ; Labrecque, J; Leung, C; Luo, X; Martino, G; Pare, M; Payza, K; Popovic, N; Projean, D; Santhakumar, V; Walpole, C; Yu, XH; Tomaszewski, MJ AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50379715 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50379715&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 57658902 160858798 CHEMBL2011124 ZINC84619798 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 50926119 CC(C)N1Cc2c(nc(nc2NCc2cnc3ccccc3c2)N2CCN(CC2)C(C)=O)C1=O InChI=1S/C25H29N7O2/c1-16(2)32-15-20-22(24(32)34)28-25(31-10-8-30(9-11-31)17(3)33)29-23(20)27-14-18-12-19-6-4-5-7-21(19)26-13-18/h4-7,12-13,16H,8-11,14-15H2,1-3H3,(H,27,28,29) CTNRCYKVGGRNOG-UHFFFAOYSA-N 50379716 CHEMBL2011125 P2X purinoceptor 3 Homo sapiens 24 ChEMBL 10.1016/j.bmcl.2012.01.124 10.7270/Q29W0GGF 22370269 Cantin, LD; Bayrakdarian, M; Buon, C; Grazzini, E; Hu, YJ; Labrecque, J; Leung, C; Luo, X; Martino, G; Pare, M; Payza, K; Popovic, N; Projean, D; Santhakumar, V; Walpole, C; Yu, XH; Tomaszewski, MJ AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50379716 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50379716&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 57431914 160858799 CHEMBL2011125 ZINC84635490 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 50926120 CC(C)N1Cc2c(nc(nc2NCc2cc3ccccc3cn2)N2CCN(CC2)C(C)=O)C1=O InChI=1S/C25H29N7O2/c1-16(2)32-15-21-22(24(32)34)28-25(31-10-8-30(9-11-31)17(3)33)29-23(21)27-14-20-12-18-6-4-5-7-19(18)13-26-20/h4-7,12-13,16H,8-11,14-15H2,1-3H3,(H,27,28,29) KDIZLZUNMOJKHK-UHFFFAOYSA-N 50379717 CHEMBL2011126 P2X purinoceptor 3 Homo sapiens 24 ChEMBL 10.1016/j.bmcl.2012.01.124 10.7270/Q29W0GGF 22370269 Cantin, LD; Bayrakdarian, M; Buon, C; Grazzini, E; Hu, YJ; Labrecque, J; Leung, C; Luo, X; Martino, G; Pare, M; Payza, K; Popovic, N; Projean, D; Santhakumar, V; Walpole, C; Yu, XH; Tomaszewski, MJ AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50379717 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50379717&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 57431852 160858800 CHEMBL2011126 ZINC43200629 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 50926121 CC(C)N1Cc2c(nc(nc2N(C)Cc2cc3ccccc3cn2)N2CCN(CC2)C(C)=O)C1=O InChI=1S/C26H31N7O2/c1-17(2)33-16-22-23(25(33)35)28-26(32-11-9-31(10-12-32)18(3)34)29-24(22)30(4)15-21-13-19-7-5-6-8-20(19)14-27-21/h5-8,13-14,17H,9-12,15-16H2,1-4H3 NUCDMFSRNOBIBN-UHFFFAOYSA-N 50379718 CHEMBL2011127 P2X purinoceptor 3 Homo sapiens 22 ChEMBL 10.1016/j.bmcl.2012.01.124 10.7270/Q29W0GGF 22370269 Cantin, LD; Bayrakdarian, M; Buon, C; Grazzini, E; Hu, YJ; Labrecque, J; Leung, C; Luo, X; Martino, G; Pare, M; Payza, K; Popovic, N; Projean, D; Santhakumar, V; Walpole, C; Yu, XH; Tomaszewski, MJ AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50379718 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50379718&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 57480972 160858801 CHEMBL2011127 ZINC43200628 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 50926132 CC(C)N1Cc2c(nc(nc2NC(c2ccccc2)c2ccccc2)N2CCOCC2)C1=O InChI=1S/C26H29N5O2/c1-18(2)31-17-21-23(25(31)32)28-26(30-13-15-33-16-14-30)29-24(21)27-22(19-9-5-3-6-10-19)20-11-7-4-8-12-20/h3-12,18,22H,13-17H2,1-2H3,(H,27,28,29) RPJHSXJLMIVPDA-UHFFFAOYSA-N 50379720 CHEMBL2010928 P2X purinoceptor 3 Homo sapiens 1360 ChEMBL 10.1016/j.bmcl.2012.01.124 10.7270/Q29W0GGF 22370269 Cantin, LD; Bayrakdarian, M; Buon, C; Grazzini, E; Hu, YJ; Labrecque, J; Leung, C; Luo, X; Martino, G; Pare, M; Payza, K; Popovic, N; Projean, D; Santhakumar, V; Walpole, C; Yu, XH; Tomaszewski, MJ AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50379720 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50379720&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 57431799 160858803 CHEMBL2010928 ZINC84634693 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 50926133 CC(C)N1Cc2c(nc(nc2NC(c2ccccc2)c2ccccc2)N2CCNCC2)C1=O InChI=1S/C26H30N6O/c1-18(2)32-17-21-23(25(32)33)29-26(31-15-13-27-14-16-31)30-24(21)28-22(19-9-5-3-6-10-19)20-11-7-4-8-12-20/h3-12,18,22,27H,13-17H2,1-2H3,(H,28,29,30) JQCUOJJGMALZGI-UHFFFAOYSA-N 50379721 CHEMBL2010929 P2X purinoceptor 3 Homo sapiens 618 ChEMBL 10.1016/j.bmcl.2012.01.124 10.7270/Q29W0GGF 22370269 Cantin, LD; Bayrakdarian, M; Buon, C; Grazzini, E; Hu, YJ; Labrecque, J; Leung, C; Luo, X; Martino, G; Pare, M; Payza, K; Popovic, N; Projean, D; Santhakumar, V; Walpole, C; Yu, XH; Tomaszewski, MJ AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50379721 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50379721&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 25117612 160858804 CHEMBL2010929 ZINC84634695 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 50926134 CC(C)N1Cc2c(nc(nc2NC(c2ccccc2)c2ccccc2)N2CCC(C2)NC(C)=O)C1=O InChI=1S/C28H32N6O2/c1-18(2)34-17-23-25(27(34)36)31-28(33-15-14-22(16-33)29-19(3)35)32-26(23)30-24(20-10-6-4-7-11-20)21-12-8-5-9-13-21/h4-13,18,22,24H,14-17H2,1-3H3,(H,29,35)(H,30,31,32) FZKIGBASZIKYCO-UHFFFAOYSA-N 50379722 CHEMBL2010930 P2X purinoceptor 3 Homo sapiens 327 ChEMBL 10.1016/j.bmcl.2012.01.124 10.7270/Q29W0GGF 22370269 Cantin, LD; Bayrakdarian, M; Buon, C; Grazzini, E; Hu, YJ; Labrecque, J; Leung, C; Luo, X; Martino, G; Pare, M; Payza, K; Popovic, N; Projean, D; Santhakumar, V; Walpole, C; Yu, XH; Tomaszewski, MJ AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50379722 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50379722&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 57431806 160858805 CHEMBL2010930 ZINC84633346 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 50926135 CC(C)N1Cc2c(nc(nc2NC(c2ccccc2)c2ccccc2)N2CCN(C)CC2)C1=O InChI=1S/C27H32N6O/c1-19(2)33-18-22-24(26(33)34)29-27(32-16-14-31(3)15-17-32)30-25(22)28-23(20-10-6-4-7-11-20)21-12-8-5-9-13-21/h4-13,19,23H,14-18H2,1-3H3,(H,28,29,30) CYDJGGOXXCSUBQ-UHFFFAOYSA-N 50379723 CHEMBL2010932 P2X purinoceptor 3 Homo sapiens 1947 ChEMBL 10.1016/j.bmcl.2012.01.124 10.7270/Q29W0GGF 22370269 Cantin, LD; Bayrakdarian, M; Buon, C; Grazzini, E; Hu, YJ; Labrecque, J; Leung, C; Luo, X; Martino, G; Pare, M; Payza, K; Popovic, N; Projean, D; Santhakumar, V; Walpole, C; Yu, XH; Tomaszewski, MJ AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50379723 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50379723&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 57658920 160858806 CHEMBL2010932 ZINC84634511 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 50926136 CC(C)N1Cc2c(nc(nc2NC(c2ccccc2)c2ccccc2)N2CCN(CC2)C(C)=O)C1=O InChI=1S/C28H32N6O2/c1-19(2)34-18-23-25(27(34)36)30-28(33-16-14-32(15-17-33)20(3)35)31-26(23)29-24(21-10-6-4-7-11-21)22-12-8-5-9-13-22/h4-13,19,24H,14-18H2,1-3H3,(H,29,30,31) GBKVUQVWUBJGLI-UHFFFAOYSA-N 50379724 CHEMBL2010933 P2X purinoceptor 3 Homo sapiens 268 ChEMBL 10.1016/j.bmcl.2012.01.124 10.7270/Q29W0GGF 22370269 Cantin, LD; Bayrakdarian, M; Buon, C; Grazzini, E; Hu, YJ; Labrecque, J; Leung, C; Luo, X; Martino, G; Pare, M; Payza, K; Popovic, N; Projean, D; Santhakumar, V; Walpole, C; Yu, XH; Tomaszewski, MJ AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50379724 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50379724&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 57431796 160858807 CHEMBL2010933 ZINC84615812 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 50926137 CC(C)N1Cc2c(nc(nc2NC(c2ccccc2)c2ccccc2)N2CCN(CC2)S(C)(=O)=O)C1=O InChI=1S/C27H32N6O3S/c1-19(2)33-18-22-24(26(33)34)29-27(31-14-16-32(17-15-31)37(3,35)36)30-25(22)28-23(20-10-6-4-7-11-20)21-12-8-5-9-13-21/h4-13,19,23H,14-18H2,1-3H3,(H,28,29,30) IJNLEZBNSKBHNS-UHFFFAOYSA-N 50379725 CHEMBL2011102 P2X purinoceptor 3 Homo sapiens 398 ChEMBL 10.1016/j.bmcl.2012.01.124 10.7270/Q29W0GGF 22370269 Cantin, LD; Bayrakdarian, M; Buon, C; Grazzini, E; Hu, YJ; Labrecque, J; Leung, C; Luo, X; Martino, G; Pare, M; Payza, K; Popovic, N; Projean, D; Santhakumar, V; Walpole, C; Yu, XH; Tomaszewski, MJ AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50379725 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50379725&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 25117615 160858808 CHEMBL2011102 ZINC84632682 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 50926138 CC(C)N1Cc2c(nc(nc2NC(c2ccccc2)c2ccccc2)N2CCN(CC(=O)N(C)C)CC2)C1=O InChI=1S/C30H37N7O2/c1-21(2)37-19-24-27(29(37)39)32-30(36-17-15-35(16-18-36)20-25(38)34(3)4)33-28(24)31-26(22-11-7-5-8-12-22)23-13-9-6-10-14-23/h5-14,21,26H,15-20H2,1-4H3,(H,31,32,33) YUCRALCIVJRUKP-UHFFFAOYSA-N 50379726 CHEMBL2011103 P2X purinoceptor 3 Homo sapiens 440 ChEMBL 10.1016/j.bmcl.2012.01.124 10.7270/Q29W0GGF 22370269 Cantin, LD; Bayrakdarian, M; Buon, C; Grazzini, E; Hu, YJ; Labrecque, J; Leung, C; Luo, X; Martino, G; Pare, M; Payza, K; Popovic, N; Projean, D; Santhakumar, V; Walpole, C; Yu, XH; Tomaszewski, MJ AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50379726 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50379726&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 57431802 160858809 CHEMBL2011103 ZINC84633390 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 50926139 CC(C)N1Cc2c(nc(nc2NC(c2ccccc2)c2ccccc2)N2CCN(CC2)C(=O)CN(C)C)C1=O InChI=1S/C30H37N7O2/c1-21(2)37-19-24-27(29(37)39)32-30(36-17-15-35(16-18-36)25(38)20-34(3)4)33-28(24)31-26(22-11-7-5-8-12-22)23-13-9-6-10-14-23/h5-14,21,26H,15-20H2,1-4H3,(H,31,32,33) CYGDBXVUEQBTGM-UHFFFAOYSA-N 50379727 CHEMBL2011104 P2X purinoceptor 3 Homo sapiens 5689 ChEMBL 10.1016/j.bmcl.2012.01.124 10.7270/Q29W0GGF 22370269 Cantin, LD; Bayrakdarian, M; Buon, C; Grazzini, E; Hu, YJ; Labrecque, J; Leung, C; Luo, X; Martino, G; Pare, M; Payza, K; Popovic, N; Projean, D; Santhakumar, V; Walpole, C; Yu, XH; Tomaszewski, MJ AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50379727 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50379727&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 25117983 160858810 CHEMBL2011104 ZINC84633393 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 50926140 CC(C)N1Cc2c(nc(nc2NCc2ccccc2)N2CCN(CC2)C(C)=O)C1=O InChI=1S/C22H28N6O2/c1-15(2)28-14-18-19(21(28)30)24-22(27-11-9-26(10-12-27)16(3)29)25-20(18)23-13-17-7-5-4-6-8-17/h4-8,15H,9-14H2,1-3H3,(H,23,24,25) IUCLLGCMSSTZTK-UHFFFAOYSA-N 50379728 CHEMBL2011105 P2X purinoceptor 3 Homo sapiens >30000 ChEMBL 10.1016/j.bmcl.2012.01.124 10.7270/Q29W0GGF 22370269 Cantin, LD; Bayrakdarian, M; Buon, C; Grazzini, E; Hu, YJ; Labrecque, J; Leung, C; Luo, X; Martino, G; Pare, M; Payza, K; Popovic, N; Projean, D; Santhakumar, V; Walpole, C; Yu, XH; Tomaszewski, MJ AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50379728 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50379728&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 57500058 160858811 CHEMBL2011105 ZINC84633394 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 50926141 CC(C)N1Cc2c(nc(nc2NCCc2ccccc2)N2CCN(CC2)C(C)=O)C1=O InChI=1S/C23H30N6O2/c1-16(2)29-15-19-20(22(29)31)25-23(28-13-11-27(12-14-28)17(3)30)26-21(19)24-10-9-18-7-5-4-6-8-18/h4-8,16H,9-15H2,1-3H3,(H,24,25,26) VNGYCXKYSUSIRP-UHFFFAOYSA-N 50379729 CHEMBL2011106 P2X purinoceptor 3 Homo sapiens 13950 ChEMBL 10.1016/j.bmcl.2012.01.124 10.7270/Q29W0GGF 22370269 Cantin, LD; Bayrakdarian, M; Buon, C; Grazzini, E; Hu, YJ; Labrecque, J; Leung, C; Luo, X; Martino, G; Pare, M; Payza, K; Popovic, N; Projean, D; Santhakumar, V; Walpole, C; Yu, XH; Tomaszewski, MJ AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50379729 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50379729&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 57500055 160858812 CHEMBL2011106 ZINC84619918 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 50926142 CC(C)N1Cc2c(nc(nc2NCCc2ccc(Cl)cc2)N2CCN(CC2)C(C)=O)C1=O InChI=1S/C23H29ClN6O2/c1-15(2)30-14-19-20(22(30)32)26-23(29-12-10-28(11-13-29)16(3)31)27-21(19)25-9-8-17-4-6-18(24)7-5-17/h4-7,15H,8-14H2,1-3H3,(H,25,26,27) ORGXYNQCXJQCDF-UHFFFAOYSA-N 50379730 CHEMBL2011107 P2X purinoceptor 3 Homo sapiens 1665 ChEMBL 10.1016/j.bmcl.2012.01.124 10.7270/Q29W0GGF 22370269 Cantin, LD; Bayrakdarian, M; Buon, C; Grazzini, E; Hu, YJ; Labrecque, J; Leung, C; Luo, X; Martino, G; Pare, M; Payza, K; Popovic, N; Projean, D; Santhakumar, V; Walpole, C; Yu, XH; Tomaszewski, MJ AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50379730 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50379730&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 57431779 160858813 CHEMBL2011107 ZINC84632196 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 50926143 CC(C)N1Cc2c(nc(nc2NCCc2ccc(C)cc2)N2CCN(CC2)C(C)=O)C1=O InChI=1S/C24H32N6O2/c1-16(2)30-15-20-21(23(30)32)26-24(29-13-11-28(12-14-29)18(4)31)27-22(20)25-10-9-19-7-5-17(3)6-8-19/h5-8,16H,9-15H2,1-4H3,(H,25,26,27) XCTLDOSCQAKLHY-UHFFFAOYSA-N 50379731 CHEMBL2011108 P2X purinoceptor 3 Homo sapiens 1311 ChEMBL 10.1016/j.bmcl.2012.01.124 10.7270/Q29W0GGF 22370269 Cantin, LD; Bayrakdarian, M; Buon, C; Grazzini, E; Hu, YJ; Labrecque, J; Leung, C; Luo, X; Martino, G; Pare, M; Payza, K; Popovic, N; Projean, D; Santhakumar, V; Walpole, C; Yu, XH; Tomaszewski, MJ AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50379731 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50379731&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 57431780 160858814 CHEMBL2011108 ZINC84605329 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 50926144 CC(C)N1Cc2c(nc(nc2NCC(C)c2ccc(Cl)cc2)N2CCN(CC2)C(C)=O)C1=O InChI=1S/C24H31ClN6O2/c1-15(2)31-14-20-21(23(31)33)27-24(30-11-9-29(10-12-30)17(4)32)28-22(20)26-13-16(3)18-5-7-19(25)8-6-18/h5-8,15-16H,9-14H2,1-4H3,(H,26,27,28) HZUJINQLAALSOQ-UHFFFAOYSA-N 50379732 CHEMBL2011109 P2X purinoceptor 3 Homo sapiens 441 ChEMBL 10.1016/j.bmcl.2012.01.124 10.7270/Q29W0GGF 22370269 Cantin, LD; Bayrakdarian, M; Buon, C; Grazzini, E; Hu, YJ; Labrecque, J; Leung, C; Luo, X; Martino, G; Pare, M; Payza, K; Popovic, N; Projean, D; Santhakumar, V; Walpole, C; Yu, XH; Tomaszewski, MJ AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50379732 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50379732&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 25120809 160858815 CHEMBL2011109 ZINC84605333 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 50926145 CC(C)N1Cc2c(nc(nc2NCC(C)(C)c2ccc(Cl)cc2)N2CCN(CC2)C(C)=O)C1=O InChI=1S/C25H33ClN6O2/c1-16(2)32-14-20-21(23(32)34)28-24(31-12-10-30(11-13-31)17(3)33)29-22(20)27-15-25(4,5)18-6-8-19(26)9-7-18/h6-9,16H,10-15H2,1-5H3,(H,27,28,29) YGJKLZSNEFPSTD-UHFFFAOYSA-N 50379733 CHEMBL2011110 P2X purinoceptor 3 Homo sapiens 2057 ChEMBL 10.1016/j.bmcl.2012.01.124 10.7270/Q29W0GGF 22370269 Cantin, LD; Bayrakdarian, M; Buon, C; Grazzini, E; Hu, YJ; Labrecque, J; Leung, C; Luo, X; Martino, G; Pare, M; Payza, K; Popovic, N; Projean, D; Santhakumar, V; Walpole, C; Yu, XH; Tomaszewski, MJ AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50379733 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50379733&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 25121155 160858816 CHEMBL2011110 ZINC84605335 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 50926146 CC(C)N1Cc2c(nc(nc2NCC2(CCC2)c2ccc(Cl)cc2)N2CCN(CC2)C(C)=O)C1=O InChI=1S/C26H33ClN6O2/c1-17(2)33-15-21-22(24(33)35)29-25(32-13-11-31(12-14-32)18(3)34)30-23(21)28-16-26(9-4-10-26)19-5-7-20(27)8-6-19/h5-8,17H,4,9-16H2,1-3H3,(H,28,29,30) YFZDMDKJMXKVQS-UHFFFAOYSA-N 50379734 CHEMBL2011111 P2X purinoceptor 3 Homo sapiens 262 ChEMBL 10.1016/j.bmcl.2012.01.124 10.7270/Q29W0GGF 22370269 Cantin, LD; Bayrakdarian, M; Buon, C; Grazzini, E; Hu, YJ; Labrecque, J; Leung, C; Luo, X; Martino, G; Pare, M; Payza, K; Popovic, N; Projean, D; Santhakumar, V; Walpole, C; Yu, XH; Tomaszewski, MJ AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50379734 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50379734&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 57431769 160858817 CHEMBL2011111 ZINC84614584 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 50926147 CC(C)N1Cc2c(nc(nc2NC(C)(C)Cc2ccc(Cl)cc2)N2CCN(CC2)C(C)=O)C1=O InChI=1S/C25H33ClN6O2/c1-16(2)32-15-20-21(23(32)34)27-24(31-12-10-30(11-13-31)17(3)33)28-22(20)29-25(4,5)14-18-6-8-19(26)9-7-18/h6-9,16H,10-15H2,1-5H3,(H,27,28,29) QPDPLVXCWWSXFN-UHFFFAOYSA-N 50379707 CHEMBL2011112 P2X purinoceptor 3 Homo sapiens 61 ChEMBL 10.1016/j.bmcl.2012.01.124 10.7270/Q29W0GGF 22370269 Cantin, LD; Bayrakdarian, M; Buon, C; Grazzini, E; Hu, YJ; Labrecque, J; Leung, C; Luo, X; Martino, G; Pare, M; Payza, K; Popovic, N; Projean, D; Santhakumar, V; Walpole, C; Yu, XH; Tomaszewski, MJ AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50379707 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50379707&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 25122581 160858790 CHEMBL2011112 ZINC68247086 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 50926148 CC(C)N1Cc2c(nc(nc2NCc2ccc(cc2)C(F)(F)F)N2CCN(CC2)C(C)=O)C1=O InChI=1S/C23H27F3N6O2/c1-14(2)32-13-18-19(21(32)34)28-22(31-10-8-30(9-11-31)15(3)33)29-20(18)27-12-16-4-6-17(7-5-16)23(24,25)26/h4-7,14H,8-13H2,1-3H3,(H,27,28,29) APWGKCNSBHECJN-UHFFFAOYSA-N 50379735 CHEMBL2011114 P2X purinoceptor 3 Homo sapiens 1271 ChEMBL 10.1016/j.bmcl.2012.01.124 10.7270/Q29W0GGF 22370269 Cantin, LD; Bayrakdarian, M; Buon, C; Grazzini, E; Hu, YJ; Labrecque, J; Leung, C; Luo, X; Martino, G; Pare, M; Payza, K; Popovic, N; Projean, D; Santhakumar, V; Walpole, C; Yu, XH; Tomaszewski, MJ AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50379735 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50379735&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 25121511 160858818 CHEMBL2011114 ZINC84596892 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 50926149 CC(C)N1Cc2c(nc(nc2NCc2ccc(OC(F)(F)F)cc2)N2CCN(CC2)C(C)=O)C1=O InChI=1S/C23H27F3N6O3/c1-14(2)32-13-18-19(21(32)34)28-22(31-10-8-30(9-11-31)15(3)33)29-20(18)27-12-16-4-6-17(7-5-16)35-23(24,25)26/h4-7,14H,8-13H2,1-3H3,(H,27,28,29) RBQIGTZFCHFLHE-UHFFFAOYSA-N 50379706 CHEMBL2011115 P2X purinoceptor 3 Homo sapiens 324 ChEMBL 10.1016/j.bmcl.2012.01.124 10.7270/Q29W0GGF 22370269 Cantin, LD; Bayrakdarian, M; Buon, C; Grazzini, E; Hu, YJ; Labrecque, J; Leung, C; Luo, X; Martino, G; Pare, M; Payza, K; Popovic, N; Projean, D; Santhakumar, V; Walpole, C; Yu, XH; Tomaszewski, MJ AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50379706 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50379706&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 57431775 160858789 CHEMBL2011115 ZINC84633396 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 50926150 COc1cc(OC(F)(F)F)ccc1CNc1nc(nc2C(=O)N(Cc12)C(C)C)N1CCN(CC1)C(C)=O InChI=1S/C24H29F3N6O4/c1-14(2)33-13-18-20(22(33)35)29-23(32-9-7-31(8-10-32)15(3)34)30-21(18)28-12-16-5-6-17(11-19(16)36-4)37-24(25,26)27/h5-6,11,14H,7-10,12-13H2,1-4H3,(H,28,29,30) BGLNPGCRIGALDL-UHFFFAOYSA-N 50379736 CHEMBL2011116 P2X purinoceptor 3 Homo sapiens 67 ChEMBL 10.1016/j.bmcl.2012.01.124 10.7270/Q29W0GGF 22370269 Cantin, LD; Bayrakdarian, M; Buon, C; Grazzini, E; Hu, YJ; Labrecque, J; Leung, C; Luo, X; Martino, G; Pare, M; Payza, K; Popovic, N; Projean, D; Santhakumar, V; Walpole, C; Yu, XH; Tomaszewski, MJ AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50379736 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50379736&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 57431849 160858819 CHEMBL2011116 ZINC84633398 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 50926151 CC(C)N1Cc2c(nc(nc2N[C@H](C)c2ccc(OC(F)(F)F)cc2)N2CCN(CC2)C(C)=O)C1=O InChI=1S/C24H29F3N6O3/c1-14(2)33-13-19-20(22(33)35)29-23(32-11-9-31(10-12-32)16(4)34)30-21(19)28-15(3)17-5-7-18(8-6-17)36-24(25,26)27/h5-8,14-15H,9-13H2,1-4H3,(H,28,29,30)/t15-/m1/s1 XFUQSGZNGBVIKN-OAHLLOKOSA-N 50379719 CHEMBL2011118 P2X purinoceptor 3 Homo sapiens 64 ChEMBL 10.1016/j.bmcl.2012.01.124 10.7270/Q29W0GGF 22370269 Cantin, LD; Bayrakdarian, M; Buon, C; Grazzini, E; Hu, YJ; Labrecque, J; Leung, C; Luo, X; Martino, G; Pare, M; Payza, K; Popovic, N; Projean, D; Santhakumar, V; Walpole, C; Yu, XH; Tomaszewski, MJ AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50379719 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50379719&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 25118337 160858802 CHEMBL2011118 ZINC84633914 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 50973450 O=C(NCCc1ccccc1)N1c2ccccc2Oc2ccccc12 InChI=1S/C21H18N2O2/c24-21(22-15-14-16-8-2-1-3-9-16)23-17-10-4-6-12-19(17)25-20-13-7-5-11-18(20)23/h1-13H,14-15H2,(H,22,24) PTLRJNRRUGVPRK-UHFFFAOYSA-N 50399175 CHEMBL2180171 P2X purinoceptor 3 Homo sapiens >10000 ChEMBL 10.1021/jm300845v 10.7270/Q2XK8GPN 23075067 Hernandez-Olmos, V; Abdelrahman, A; El-Tayeb, A; Freudendahl, D; Weinhausen, S; Muller, CE University of Bonn http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50399175 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50399175&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 71457337 163348199 CHEMBL2180171 ZINC95576375 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 50973451 Cc1ccc(cc1)S(=O)(=O)N1c2ccccc2Oc2ccccc12 InChI=1S/C19H15NO3S/c1-14-10-12-15(13-11-14)24(21,22)20-16-6-2-4-8-18(16)23-19-9-5-3-7-17(19)20/h2-13H,1H3 DHZNMEIBMACSFH-UHFFFAOYSA-N 50399183 CHEMBL2180160 P2X purinoceptor 3 Homo sapiens >10000 ChEMBL 10.1021/jm300845v 10.7270/Q2XK8GPN 23075067 Hernandez-Olmos, V; Abdelrahman, A; El-Tayeb, A; Freudendahl, D; Weinhausen, S; Muller, CE University of Bonn http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50399183 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50399183&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 2320735 163348207 CHEMBL2180160 ZINC03191166 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 50973513 Cc1ccc(COC(=O)N2c3ccccc3Oc3ccccc23)cc1 InChI=1S/C21H17NO3/c1-15-10-12-16(13-11-15)14-24-21(23)22-17-6-2-4-8-19(17)25-20-9-5-3-7-18(20)22/h2-13H,14H2,1H3 NVOWNIGGPNJGNW-UHFFFAOYSA-N 50399164 CHEMBL2180138 P2X purinoceptor 3 Homo sapiens >10000 ChEMBL 10.1021/jm300845v 10.7270/Q2XK8GPN 23075067 Hernandez-Olmos, V; Abdelrahman, A; El-Tayeb, A; Freudendahl, D; Weinhausen, S; Muller, CE University of Bonn http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50399164 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50399164&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 71450180 163348188 CHEMBL2180138 ZINC95580373 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 50973514 O=C(OCc1ccccc1)N1c2ccccc2Oc2ccccc12 InChI=1S/C20H15NO3/c22-20(23-14-15-8-2-1-3-9-15)21-16-10-4-6-12-18(16)24-19-13-7-5-11-17(19)21/h1-13H,14H2 KGVCOYMLGBNCDW-UHFFFAOYSA-N 50399165 CHEMBL2180137 P2X purinoceptor 3 Homo sapiens 10000 ChEMBL 10.1021/jm300845v 10.7270/Q2XK8GPN 23075067 Hernandez-Olmos, V; Abdelrahman, A; El-Tayeb, A; Freudendahl, D; Weinhausen, S; Muller, CE University of Bonn http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50399165 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50399165&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 60168729 163348189 CHEMBL2180137 ZINC95578736 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 50973515 CC(C)OC(=O)N1c2ccccc2Oc2ccccc12 InChI=1S/C16H15NO3/c1-11(2)19-16(18)17-12-7-3-5-9-14(12)20-15-10-6-4-8-13(15)17/h3-11H,1-2H3 USSSANRHRXBTLY-UHFFFAOYSA-N 50399166 CHEMBL2180136 P2X purinoceptor 3 Homo sapiens >10000 ChEMBL 10.1021/jm300845v 10.7270/Q2XK8GPN 23075067 Hernandez-Olmos, V; Abdelrahman, A; El-Tayeb, A; Freudendahl, D; Weinhausen, S; Muller, CE University of Bonn http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50399166 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50399166&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 71462707 163348190 CHEMBL2180136 ZINC95573322 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 50973512 OC1(c2ccccc2)c2ccccc2N(Cc2ccccc2)c2ccccc12 InChI=1S/C26H21NO/c28-26(21-13-5-2-6-14-21)22-15-7-9-17-24(22)27(19-20-11-3-1-4-12-20)25-18-10-8-16-23(25)26/h1-18,28H,19H2 PEMLUSSWDFVTHU-UHFFFAOYSA-N 50399190 CHEMBL2180149 P2X purinoceptor 3 Homo sapiens 429 ChEMBL 10.1021/jm300845v 10.7270/Q2XK8GPN 23075067 Hernandez-Olmos, V; Abdelrahman, A; El-Tayeb, A; Freudendahl, D; Weinhausen, S; Muller, CE University of Bonn http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50399190 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50399190&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 71459185 163348214 CHEMBL2180149 ZINC95578665 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51089245 CC(C)N(C(C)C)C(=O)N1c2ccccc2C=Cc2ccccc12 InChI=1S/C21H24N2O/c1-15(2)22(16(3)4)21(24)23-19-11-7-5-9-17(19)13-14-18-10-6-8-12-20(18)23/h5-16H,1-4H3 DZYRUGGUQGFZDF-UHFFFAOYSA-N 50446060 CHEMBL3103385 P2X purinoceptor 3 Homo sapiens 7180 ChEMBL 10.1016/j.bmc.2013.12.035 10.7270/Q21R6S09 24411477 Tian, M; Abdelrahman, A; Weinhausen, S; Hinz, S; Weyer, S; Dosa, S; El-Tayeb, A; Muller, CE University of Bonn http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50446060 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50446060&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 73669299 194943956 CHEMBL3103385 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51089246 CCCN(CCC)C(=O)N1c2ccccc2C=Cc2ccccc12 InChI=1S/C21H24N2O/c1-3-15-22(16-4-2)21(24)23-19-11-7-5-9-17(19)13-14-18-10-6-8-12-20(18)23/h5-14H,3-4,15-16H2,1-2H3 IAXQJFHTWQFLLJ-UHFFFAOYSA-N 50446068 CHEMBL3103375 P2X purinoceptor 3 Homo sapiens 15200 ChEMBL 10.1016/j.bmc.2013.12.035 10.7270/Q21R6S09 24411477 Tian, M; Abdelrahman, A; Weinhausen, S; Hinz, S; Weyer, S; Dosa, S; El-Tayeb, A; Muller, CE University of Bonn http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50446068 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50446068&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76324694 194943964 CHEMBL3103375 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51089247 O=C(N1CCCC1)N1c2ccccc2C=Cc2ccccc12 InChI=1S/C19H18N2O/c22-19(20-13-5-6-14-20)21-17-9-3-1-7-15(17)11-12-16-8-2-4-10-18(16)21/h1-4,7-12H,5-6,13-14H2 NDGTWBCNSNJJBQ-UHFFFAOYSA-N 50446069 CHEMBL3103372 P2X purinoceptor 3 Homo sapiens 29800 ChEMBL 10.1016/j.bmc.2013.12.035 10.7270/Q21R6S09 24411477 Tian, M; Abdelrahman, A; Weinhausen, S; Hinz, S; Weyer, S; Dosa, S; El-Tayeb, A; Muller, CE University of Bonn http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50446069 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50446069&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 779113 194943965 CHEMBL3103372 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51089248 O=C(N1CCCCC1)N1c2ccccc2C=Cc2ccccc12 InChI=1S/C20H20N2O/c23-20(21-14-6-1-7-15-21)22-18-10-4-2-8-16(18)12-13-17-9-3-5-11-19(17)22/h2-5,8-13H,1,6-7,14-15H2 YOBBOVRZEZSALX-UHFFFAOYSA-N 50446070 CHEMBL3103371 P2X purinoceptor 3 Homo sapiens 7980 ChEMBL 10.1016/j.bmc.2013.12.035 10.7270/Q21R6S09 24411477 Tian, M; Abdelrahman, A; Weinhausen, S; Hinz, S; Weyer, S; Dosa, S; El-Tayeb, A; Muller, CE University of Bonn http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50446070 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50446070&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 746996 194943966 CHEMBL3103371 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51089249 O=C(NC1CCCCC1)N1c2ccccc2C=Cc2ccccc12 InChI=1S/C21H22N2O/c24-21(22-18-10-2-1-3-11-18)23-19-12-6-4-8-16(19)14-15-17-9-5-7-13-20(17)23/h4-9,12-15,18H,1-3,10-11H2,(H,22,24) DFUGSIMXDLGFTF-UHFFFAOYSA-N 50446072 CHEMBL3103369 P2X purinoceptor 3 Homo sapiens 28000 ChEMBL 10.1016/j.bmc.2013.12.035 10.7270/Q21R6S09 24411477 Tian, M; Abdelrahman, A; Weinhausen, S; Hinz, S; Weyer, S; Dosa, S; El-Tayeb, A; Muller, CE University of Bonn http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50446072 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50446072&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 921624 194943968 CHEMBL3103369 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51089250 CCN(CC)C(=O)N1c2ccccc2C=Cc2ccccc12 InChI=1S/C19H20N2O/c1-3-20(4-2)19(22)21-17-11-7-5-9-15(17)13-14-16-10-6-8-12-18(16)21/h5-14H,3-4H2,1-2H3 TXPHORZRPXNFCG-UHFFFAOYSA-N 50446076 CHEMBL1483754 P2X purinoceptor 3 Homo sapiens 14200 ChEMBL 10.1016/j.bmc.2013.12.035 10.7270/Q21R6S09 24411477 Tian, M; Abdelrahman, A; Weinhausen, S; Hinz, S; Weyer, S; Dosa, S; El-Tayeb, A; Muller, CE University of Bonn http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50446076 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50446076&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 766793 194943972 CHEMBL1483754 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51086108 Cc1nc(N=Nc2ccc(cc2S(O)(=O)=O)S(O)(=O)=O)c(COP(O)(O)=O)c(C=O)c1O InChI=1S/C14H14N3O12PS2/c1-7-13(19)9(5-18)10(6-29-30(20,21)22)14(15-7)17-16-11-3-2-8(31(23,24)25)4-12(11)32(26,27)28/h2-5,19H,6H2,1H3,(H2,20,21,22)(H,23,24,25)(H,26,27,28) PNFZSRRRZNXSMF-UHFFFAOYSA-N 85043 CAS_149017-66-3::CHEMBL69234::NSC_6093163::PPADS P2X purinoceptor 3 Homo sapiens 240 ChEMBL 10.1016/j.ejmech.2013.10.026 10.7270/Q2M61MQH 24246730 Cho, JH; Jung, KY; Jung, Y; Kim, MH; Ko, H; Park, CS; Kim, YC Gwangju Institute of Science and Technology (GIST) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=85043 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=85043&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 5478935 136351143 CHEMBL69234 ZINC18247107 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51086111 OC(=O)c1cc(C(O)=O)c(cc1C(O)=O)C(=O)N(Cc1cccc(Oc2ccccc2)c1)[C@H]1CCCc2ccccc12 InChI=1S/C33H27NO8/c35-30(25-17-27(32(38)39)28(33(40)41)18-26(25)31(36)37)34(29-15-7-10-21-9-4-5-14-24(21)29)19-20-8-6-13-23(16-20)42-22-11-2-1-3-12-22/h1-6,8-9,11-14,16-18,29H,7,10,15,19H2,(H,36,37)(H,38,39)(H,40,41)/t29-/m0/s1 VQGBOYBIENNKMI-LJAQVGFWSA-N 86478 A-317491 P2X purinoceptor 3 Homo sapiens 97 ChEMBL 10.1016/j.ejmech.2013.10.026 10.7270/Q2M61MQH 24246730 Cho, JH; Jung, KY; Jung, Y; Kim, MH; Ko, H; Park, CS; Kim, YC Gwangju Institute of Science and Technology (GIST) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86478 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86478&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 71C 5SVR 9829395 136352527 4115 ZINC03990058 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51086113 Cc1nc(-c2cccc(Oc3ccccc3)c2)c(C(O)=O)c(C(O)=O)c1O InChI=1S/C20H15NO6/c1-11-18(22)16(20(25)26)15(19(23)24)17(21-11)12-6-5-9-14(10-12)27-13-7-3-2-4-8-13/h2-10,22H,1H3,(H,23,24)(H,25,26) CDAIMRKZCYXGTE-UHFFFAOYSA-N 50444415 CHEMBL3091621 P2X purinoceptor 3 Homo sapiens 3300 ChEMBL 10.1016/j.ejmech.2013.10.026 10.7270/Q2M61MQH 24246730 Cho, JH; Jung, KY; Jung, Y; Kim, MH; Ko, H; Park, CS; Kim, YC Gwangju Institute of Science and Technology (GIST) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50444415 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50444415&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76313648 194942311 CHEMBL3091621 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51086114 Cc1nc(Cc2ccccc2Oc2ccccc2)c(C(O)=O)c(C(O)=O)c1O InChI=1S/C21H17NO6/c1-12-19(23)18(21(26)27)17(20(24)25)15(22-12)11-13-7-5-6-10-16(13)28-14-8-3-2-4-9-14/h2-10,23H,11H2,1H3,(H,24,25)(H,26,27) SCFALBJIJMZSOU-UHFFFAOYSA-N 50444416 CHEMBL3091623 P2X purinoceptor 3 Homo sapiens 2930 ChEMBL 10.1016/j.ejmech.2013.10.026 10.7270/Q2M61MQH 24246730 Cho, JH; Jung, KY; Jung, Y; Kim, MH; Ko, H; Park, CS; Kim, YC Gwangju Institute of Science and Technology (GIST) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50444416 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50444416&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76324525 194942312 CHEMBL3091623 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51086115 Cc1nc(Cc2ccc(Oc3ccccc3)cc2)c(C(O)=O)c(C(O)=O)c1O InChI=1S/C21H17NO6/c1-12-19(23)18(21(26)27)17(20(24)25)16(22-12)11-13-7-9-15(10-8-13)28-14-5-3-2-4-6-14/h2-10,23H,11H2,1H3,(H,24,25)(H,26,27) ITDYHRXXHMVPSV-UHFFFAOYSA-N 50444417 CHEMBL3091622 P2X purinoceptor 3 Homo sapiens 1050 ChEMBL 10.1016/j.ejmech.2013.10.026 10.7270/Q2M61MQH 24246730 Cho, JH; Jung, KY; Jung, Y; Kim, MH; Ko, H; Park, CS; Kim, YC Gwangju Institute of Science and Technology (GIST) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50444417 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50444417&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76335353 194942313 CHEMBL3091622 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51086116 Cc1nc(\C=C\c2ccccc2)c(C(O)=O)c(C(O)=O)c1O InChI=1S/C16H13NO5/c1-9-14(18)13(16(21)22)12(15(19)20)11(17-9)8-7-10-5-3-2-4-6-10/h2-8,18H,1H3,(H,19,20)(H,21,22)/b8-7+ UXEIPHRTFRCYLJ-BQYQJAHWSA-N 50444418 CHEMBL3091606 P2X purinoceptor 3 Homo sapiens 920 ChEMBL 10.1016/j.ejmech.2013.10.026 10.7270/Q2M61MQH 24246730 Cho, JH; Jung, KY; Jung, Y; Kim, MH; Ko, H; Park, CS; Kim, YC Gwangju Institute of Science and Technology (GIST) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50444418 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50444418&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 54590936 194942314 CHEMBL3091606 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51086117 Cc1nc(NC(=O)c2ccccc2)c(C(O)=O)c(C(O)=O)c1O InChI=1S/C15H12N2O6/c1-7-11(18)9(14(20)21)10(15(22)23)12(16-7)17-13(19)8-5-3-2-4-6-8/h2-6,18H,1H3,(H,20,21)(H,22,23)(H,16,17,19) XSMLYQXUYICKBI-UHFFFAOYSA-N 50444419 CHEMBL3091625 P2X purinoceptor 3 Homo sapiens 723 ChEMBL 10.1016/j.ejmech.2013.10.026 10.7270/Q2M61MQH 24246730 Cho, JH; Jung, KY; Jung, Y; Kim, MH; Ko, H; Park, CS; Kim, YC Gwangju Institute of Science and Technology (GIST) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50444419 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50444419&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76309930 194942315 CHEMBL3091625 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51086118 Cc1nc(CCc2ccccc2)c(C(O)=O)c(C(O)=O)c1O InChI=1S/C16H15NO5/c1-9-14(18)13(16(21)22)12(15(19)20)11(17-9)8-7-10-5-3-2-4-6-10/h2-6,18H,7-8H2,1H3,(H,19,20)(H,21,22) KKYVRXLPMBWXMS-UHFFFAOYSA-N 50444420 CHEMBL3091605 P2X purinoceptor 3 Homo sapiens 797 ChEMBL 10.1016/j.ejmech.2013.10.026 10.7270/Q2M61MQH 24246730 Cho, JH; Jung, KY; Jung, Y; Kim, MH; Ko, H; Park, CS; Kim, YC Gwangju Institute of Science and Technology (GIST) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50444420 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50444420&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 54590854 194942316 CHEMBL3091605 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51086119 Cc1nc(Cc2cccc3ccccc23)c(CCC(O)=O)c(C=O)c1O InChI=1S/C21H19NO4/c1-13-21(26)18(12-23)17(9-10-20(24)25)19(22-13)11-15-7-4-6-14-5-2-3-8-16(14)15/h2-8,12,26H,9-11H2,1H3,(H,24,25) AUWOHRUFVOQPRJ-UHFFFAOYSA-N 50444421 CHEMBL3091629 P2X purinoceptor 3 Homo sapiens 636 ChEMBL 10.1016/j.ejmech.2013.10.026 10.7270/Q2M61MQH 24246730 Cho, JH; Jung, KY; Jung, Y; Kim, MH; Ko, H; Park, CS; Kim, YC Gwangju Institute of Science and Technology (GIST) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50444421 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50444421&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76331762 194942317 CHEMBL3091629 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51086120 Cc1nc(NC(=O)c2cccc(Oc3ccccc3)c2)c(C(O)=O)c(C(O)=O)c1O InChI=1S/C21H16N2O7/c1-11-17(24)15(20(26)27)16(21(28)29)18(22-11)23-19(25)12-6-5-9-14(10-12)30-13-7-3-2-4-8-13/h2-10,24H,1H3,(H,26,27)(H,28,29)(H,22,23,25) BJJOKXWELPHPFL-UHFFFAOYSA-N 50444422 CHEMBL3091627 P2X purinoceptor 3 Homo sapiens 928 ChEMBL 10.1016/j.ejmech.2013.10.026 10.7270/Q2M61MQH 24246730 Cho, JH; Jung, KY; Jung, Y; Kim, MH; Ko, H; Park, CS; Kim, YC Gwangju Institute of Science and Technology (GIST) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50444422 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50444422&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76324526 194942318 CHEMBL3091627 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51086121 Cc1nc(Cc2cccc3ccccc23)c2C(=O)OC(O)c2c1O InChI=1S/C19H15NO4/c1-10-17(21)16-15(18(22)24-19(16)23)14(20-10)9-12-7-4-6-11-5-2-3-8-13(11)12/h2-8,19,21,23H,9H2,1H3 IDPABNXMXCDFDX-UHFFFAOYSA-N 50444423 CHEMBL3091634 P2X purinoceptor 3 Homo sapiens 856 ChEMBL 10.1016/j.ejmech.2013.10.026 10.7270/Q2M61MQH 24246730 Cho, JH; Jung, KY; Jung, Y; Kim, MH; Ko, H; Park, CS; Kim, YC Gwangju Institute of Science and Technology (GIST) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50444423 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50444423&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76331765 194942319 CHEMBL3091634 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51086122 Cc1nc(Cc2cccc(Oc3ccccc3)c2)c(CCC(O)=O)c(C(O)=O)c1O InChI=1S/C23H21NO6/c1-14-22(27)21(23(28)29)18(10-11-20(25)26)19(24-14)13-15-6-5-9-17(12-15)30-16-7-3-2-4-8-16/h2-9,12,27H,10-11,13H2,1H3,(H,25,26)(H,28,29) XICUGIVKIBHPFC-UHFFFAOYSA-N 50444424 CHEMBL3091633 P2X purinoceptor 3 Homo sapiens 638 ChEMBL 10.1016/j.ejmech.2013.10.026 10.7270/Q2M61MQH 24246730 Cho, JH; Jung, KY; Jung, Y; Kim, MH; Ko, H; Park, CS; Kim, YC Gwangju Institute of Science and Technology (GIST) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50444424 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50444424&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76331764 194942320 CHEMBL3091633 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51086123 COc1ccc(CCc2nc(C)c(O)c(C(O)=O)c2C(O)=O)cc1 InChI=1S/C17H17NO6/c1-9-15(19)14(17(22)23)13(16(20)21)12(18-9)8-5-10-3-6-11(24-2)7-4-10/h3-4,6-7,19H,5,8H2,1-2H3,(H,20,21)(H,22,23) CWFOFIFVKUHVGE-UHFFFAOYSA-N 50444425 CHEMBL3091607 P2X purinoceptor 3 Homo sapiens 460 ChEMBL 10.1016/j.ejmech.2013.10.026 10.7270/Q2M61MQH 24246730 Cho, JH; Jung, KY; Jung, Y; Kim, MH; Ko, H; Park, CS; Kim, YC Gwangju Institute of Science and Technology (GIST) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50444425 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50444425&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 54590935 194942321 CHEMBL3091607 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51086124 Cc1nc(CC(c2ccccc2)c2ccccc2)c(C(O)=O)c(C(O)=O)c1O InChI=1S/C22H19NO5/c1-13-20(24)19(22(27)28)18(21(25)26)17(23-13)12-16(14-8-4-2-5-9-14)15-10-6-3-7-11-15/h2-11,16,24H,12H2,1H3,(H,25,26)(H,27,28) XGKYULQERWQZOR-UHFFFAOYSA-N 50444426 CHEMBL3091618 P2X purinoceptor 3 Homo sapiens 824 ChEMBL 10.1016/j.ejmech.2013.10.026 10.7270/Q2M61MQH 24246730 Cho, JH; Jung, KY; Jung, Y; Kim, MH; Ko, H; Park, CS; Kim, YC Gwangju Institute of Science and Technology (GIST) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50444426 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50444426&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 54591029 194942322 CHEMBL3091618 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51086125 Cc1nc(Cc2cccc(Oc3ccccc3)c2)c(CCC(O)=O)c(C=O)c1O InChI=1S/C23H21NO5/c1-15-23(28)20(14-25)19(10-11-22(26)27)21(24-15)13-16-6-5-9-18(12-16)29-17-7-3-2-4-8-17/h2-9,12,14,28H,10-11,13H2,1H3,(H,26,27) JFBRYAUUBAOZRW-UHFFFAOYSA-N 50444427 CHEMBL3091631 P2X purinoceptor 3 Homo sapiens 366 ChEMBL 10.1016/j.ejmech.2013.10.026 10.7270/Q2M61MQH 24246730 Cho, JH; Jung, KY; Jung, Y; Kim, MH; Ko, H; Park, CS; Kim, YC Gwangju Institute of Science and Technology (GIST) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50444427 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50444427&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76331763 194942323 CHEMBL3091631 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51086126 Cc1nc(Cc2cccc(Oc3ccccc3)c2)c2C(=O)OC(O)c2c1O InChI=1S/C21H17NO5/c1-12-19(23)18-17(20(24)27-21(18)25)16(22-12)11-13-6-5-9-15(10-13)26-14-7-3-2-4-8-14/h2-10,21,23,25H,11H2,1H3 QGOZCMVVOFYVGW-UHFFFAOYSA-N 50444428 CHEMBL3091635 P2X purinoceptor 3 Homo sapiens 652 ChEMBL 10.1016/j.ejmech.2013.10.026 10.7270/Q2M61MQH 24246730 Cho, JH; Jung, KY; Jung, Y; Kim, MH; Ko, H; Park, CS; Kim, YC Gwangju Institute of Science and Technology (GIST) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50444428 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50444428&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76324528 194942324 CHEMBL3091635 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51086127 Cc1nc(CCc2cccc(Oc3ccccc3)c2)c(C(O)=O)c(C(O)=O)c1O InChI=1S/C22H19NO6/c1-13-20(24)19(22(27)28)18(21(25)26)17(23-13)11-10-14-6-5-9-16(12-14)29-15-7-3-2-4-8-15/h2-9,12,24H,10-11H2,1H3,(H,25,26)(H,27,28) HNVUMYGVMBZFFX-UHFFFAOYSA-N 50444429 CHEMBL3091620 P2X purinoceptor 3 Homo sapiens 587 ChEMBL 10.1016/j.ejmech.2013.10.026 10.7270/Q2M61MQH 24246730 Cho, JH; Jung, KY; Jung, Y; Kim, MH; Ko, H; Park, CS; Kim, YC Gwangju Institute of Science and Technology (GIST) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50444429 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50444429&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76309929 194942325 CHEMBL3091620 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51086128 Cc1nc(Cc2cccc3ccccc23)c(C(O)=O)c(C(O)=O)c1O InChI=1S/C19H15NO5/c1-10-17(21)16(19(24)25)15(18(22)23)14(20-10)9-12-7-4-6-11-5-2-3-8-13(11)12/h2-8,21H,9H2,1H3,(H,22,23)(H,24,25) GWBXHPALJXVBSG-UHFFFAOYSA-N 50444430 CHEMBL3091617 P2X purinoceptor 3 Homo sapiens 1250 ChEMBL 10.1016/j.ejmech.2013.10.026 10.7270/Q2M61MQH 24246730 Cho, JH; Jung, KY; Jung, Y; Kim, MH; Ko, H; Park, CS; Kim, YC Gwangju Institute of Science and Technology (GIST) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50444430 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50444430&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 54591030 194942326 CHEMBL3091617 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51086129 Cc1nc(Cc2cccc3ccccc23)c(\C=C\C(O)=O)c(C=O)c1O InChI=1S/C21H17NO4/c1-13-21(26)18(12-23)17(9-10-20(24)25)19(22-13)11-15-7-4-6-14-5-2-3-8-16(14)15/h2-10,12,26H,11H2,1H3,(H,24,25)/b10-9+ WMQCLIDCYHPNTF-MDZDMXLPSA-N 50444431 CHEMBL3091628 P2X purinoceptor 3 Homo sapiens 145 ChEMBL 10.1016/j.ejmech.2013.10.026 10.7270/Q2M61MQH 24246730 Cho, JH; Jung, KY; Jung, Y; Kim, MH; Ko, H; Park, CS; Kim, YC Gwangju Institute of Science and Technology (GIST) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50444431 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50444431&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76317151 194942327 CHEMBL3091628 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51086130 Cc1nc(CCc2ccc(cc2)C(O)=O)c(C(O)=O)c(C(O)=O)c1O InChI=1S/C17H15NO7/c1-8-14(19)13(17(24)25)12(16(22)23)11(18-8)7-4-9-2-5-10(6-3-9)15(20)21/h2-3,5-6,19H,4,7H2,1H3,(H,20,21)(H,22,23)(H,24,25) VJIHHWLYLHVKCJ-UHFFFAOYSA-N 50444432 CHEMBL3091610 P2X purinoceptor 3 Homo sapiens 458 ChEMBL 10.1016/j.ejmech.2013.10.026 10.7270/Q2M61MQH 24246730 Cho, JH; Jung, KY; Jung, Y; Kim, MH; Ko, H; Park, CS; Kim, YC Gwangju Institute of Science and Technology (GIST) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50444432 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50444432&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 54590937 194942328 CHEMBL3091610 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51086132 Cc1nc(Cc2cccc(Oc3ccccc3)c2)c(\C=C\C(O)=O)c(C(O)=O)c1O InChI=1S/C23H19NO6/c1-14-22(27)21(23(28)29)18(10-11-20(25)26)19(24-14)13-15-6-5-9-17(12-15)30-16-7-3-2-4-8-16/h2-12,27H,13H2,1H3,(H,25,26)(H,28,29)/b11-10+ MKNIXRHHAJLGLW-ZHACJKMWSA-N 50444433 CHEMBL3091632 P2X purinoceptor 3 Homo sapiens 377 ChEMBL 10.1016/j.ejmech.2013.10.026 10.7270/Q2M61MQH 24246730 Cho, JH; Jung, KY; Jung, Y; Kim, MH; Ko, H; Park, CS; Kim, YC Gwangju Institute of Science and Technology (GIST) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50444433 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50444433&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76324527 194942329 CHEMBL3091632 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51086133 Cc1nc(Cc2cccc(Oc3ccccc3)c2)c(\C=C\C(O)=O)c(C=O)c1O InChI=1S/C23H19NO5/c1-15-23(28)20(14-25)19(10-11-22(26)27)21(24-15)13-16-6-5-9-18(12-16)29-17-7-3-2-4-8-17/h2-12,14,28H,13H2,1H3,(H,26,27)/b11-10+ NRQMQLIOIVRYHC-ZHACJKMWSA-N 50444434 CHEMBL3091630 P2X purinoceptor 3 Homo sapiens 60 ChEMBL 10.1016/j.ejmech.2013.10.026 10.7270/Q2M61MQH 24246730 Cho, JH; Jung, KY; Jung, Y; Kim, MH; Ko, H; Park, CS; Kim, YC Gwangju Institute of Science and Technology (GIST) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50444434 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50444434&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76320868 194942330 CHEMBL3091630 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51086135 Cc1nc(Cc2cccc(Oc3ccccc3)c2)c(C(O)=O)c(C(O)=O)c1O InChI=1S/C21H17NO6/c1-12-19(23)18(21(26)27)17(20(24)25)16(22-12)11-13-6-5-9-15(10-13)28-14-7-3-2-4-8-14/h2-10,23H,11H2,1H3,(H,24,25)(H,26,27) KBSPSFPUZOWENM-UHFFFAOYSA-N 50444435 CHEMBL3091619 P2X purinoceptor 3 Homo sapiens 474 ChEMBL 10.1016/j.ejmech.2013.10.026 10.7270/Q2M61MQH 24246730 Cho, JH; Jung, KY; Jung, Y; Kim, MH; Ko, H; Park, CS; Kim, YC Gwangju Institute of Science and Technology (GIST) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50444435 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50444435&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76328091 194942331 CHEMBL3091619 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51086140 OC(=O)c1cc(C(O)=O)c(cc1C(O)=O)C(=O)N(Cc1cccc(Oc2ccccc2)c1)[C@H]1CCCc2ccccc12 InChI=1S/C33H27NO8/c35-30(25-17-27(32(38)39)28(33(40)41)18-26(25)31(36)37)34(29-15-7-10-21-9-4-5-14-24(21)29)19-20-8-6-13-23(16-20)42-22-11-2-1-3-12-22/h1-6,8-9,11-14,16-18,29H,7,10,15,19H2,(H,36,37)(H,38,39)(H,40,41)/t29-/m0/s1 VQGBOYBIENNKMI-LJAQVGFWSA-N 86478 A-317491 P2X purinoceptor 3 Homo sapiens 35 ChEMBL 10.1016/j.ejmech.2013.10.026 10.7270/Q2M61MQH 24246730 Cho, JH; Jung, KY; Jung, Y; Kim, MH; Ko, H; Park, CS; Kim, YC Gwangju Institute of Science and Technology (GIST) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86478 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86478&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 71C 5SVR 9829395 136352527 4115 ZINC03990058 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51045174 CC(C)N1Cc2c(nc(nc2N[C@H](C)c2cnc3ccccc3c2)N2CCN(CC2)C(C)=O)C1=O InChI=1S/C26H31N7O2/c1-16(2)33-15-21-23(25(33)35)29-26(32-11-9-31(10-12-32)18(4)34)30-24(21)28-17(3)20-13-19-7-5-6-8-22(19)27-14-20/h5-8,13-14,16-17H,9-12,15H2,1-4H3,(H,28,29,30)/t17-/m1/s1 UCUPKBZOPSOXOE-QGZVFWFLSA-N 50426572 CHEMBL2324342 P2X purinoceptor 3 Homo sapiens 21 ChEMBL 10.1021/jm3011433 10.7270/Q23B61GZ 23121096 Bagal, SK; Brown, AD; Cox, PJ; Omoto, K; Owen, RM; Pryde, DC; Sidders, B; Skerratt, SE; Stevens, EB; Storer, RI; Swain, NA Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50426572 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50426572&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 57658907 164155447 CHEMBL2324342 ZINC95581393 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51045175 CC(C)N1Cc2c(nc(nc2NCc2cnc3ccccc3c2)N2CCN(CC2)C(C)=O)C1=O InChI=1S/C25H29N7O2/c1-16(2)32-15-20-22(24(32)34)28-25(31-10-8-30(9-11-31)17(3)33)29-23(20)27-14-18-12-19-6-4-5-7-21(19)26-13-18/h4-7,12-13,16H,8-11,14-15H2,1-3H3,(H,27,28,29) CTNRCYKVGGRNOG-UHFFFAOYSA-N 50379716 CHEMBL2011125 P2X purinoceptor 3 Homo sapiens 24 ChEMBL 10.1021/jm3011433 10.7270/Q23B61GZ 23121096 Bagal, SK; Brown, AD; Cox, PJ; Omoto, K; Owen, RM; Pryde, DC; Sidders, B; Skerratt, SE; Stevens, EB; Storer, RI; Swain, NA Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50379716 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50379716&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 57431914 160858799 CHEMBL2011125 ZINC84635490 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 470557 CCCOc1ccc(Nc2nc(=O)n(CCO)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C21H22ClFN4O4/c1-2-11-31-18-8-7-16(12-17(18)23)24-19-25-20(29)26(9-10-28)21(30)27(19)13-14-3-5-15(22)6-4-14/h3-8,12,28H,2,9-11,13H2,1H3,(H,24,25,29) IAXQCPJUCZINLK-UHFFFAOYSA-N 183161 US9150546, I-321::US9688643, I-321::US9718790, I-0321 P2X purinoceptor 3 Homo sapiens 33 US Patent 10.7270/Q2M32SZ2 aid1794965 US9688643 PubChem, PC; Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183161 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183161&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821099 313634561 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51033959 [O-]S(=O)(=O)c1cc(c2c(NC(=O)c3ccc(F)c(NC(=O)c4cccc(NC(=O)Nc5cccc(c5)C(=O)Nc5cc(ccc5F)C(=O)Nc5ccc(c6cc(cc(c56)S([O-])(=O)=O)S([O-])(=O)=O)S([O-])(=O)=O)c4)c3)ccc(c2c1)S([O-])(=O)=O)S([O-])(=O)=O InChI=1S/C49H34F2N6O23S6/c50-33-9-7-25(47(60)54-35-11-13-39(83(69,70)71)31-19-29(81(63,64)65)21-41(43(31)35)85(75,76)77)17-37(33)56-45(58)23-3-1-5-27(15-23)52-49(62)53-28-6-2-4-24(16-28)46(59)57-38-18-26(8-10-34(38)51)48(61)55-36-12-14-40(84(72,73)74)32-20-30(82(66,67)68)22-42(44(32)36)86(78,79)80/h1-22H,(H,54,60)(H,55,61)(H,56,58)(H,57,59)(H2,52,53,62)(H,63,64,65)(H,66,67,68)(H,69,70,71)(H,72,73,74)(H,75,76,77)(H,78,79,80)/p-6 UDVIAMRWOLIUAE-UHFFFAOYSA-H 50422739 CHEMBL413145 P2X purinoceptor 3 Homo sapiens 355 ChEMBL 10.1021/jm050301p 10.7270/Q2JM2BZ7 16250663 Ullmann, H; Meis, S; Hongwiset, D; Marzian, C; Wiese, M; Nickel, P; Communi, D; Boeynaems, JM; Wolf, C; Hausmann, R; Schmalzing, G; Kassack, MU University of Bonn http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50422739 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50422739&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 91900207 164151614 CHEMBL413145 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51014728 C[C@H](CN1CCN(CC1)C(C)=O)NC(=O)c1cc2c(nn(C)c2s1)-c1ccccc1 InChI=1S/C22H27N5O2S/c1-15(14-26-9-11-27(12-10-26)16(2)28)23-21(29)19-13-18-20(17-7-5-4-6-8-17)24-25(3)22(18)30-19/h4-8,13,15H,9-12,14H2,1-3H3,(H,23,29)/t15-/m1/s1 WLMBSKSEPQCRJV-OAHLLOKOSA-N 50415550 CHEMBL599760::Ro-85 P2X purinoceptor 3 Homo sapiens 398.11 ChEMBL 10.1016/j.bmcl.2009.12.044 10.7270/Q22V2HCR 20045645 Brotherton-Pleiss, CE; Dillon, MP; Ford, AP; Gever, JR; Carter, DS; Gleason, SK; Lin, CJ; Moore, AG; Thompson, AW; Villa, M; Zhai, Y Roche Palo Alto http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50415550 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50415550&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 46175179 163364574 CHEMBL599760 ZINC45357437 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51061578 Cc1nc(N=Nc2ccc(cc2)C(O)=O)c(CCC(O)=O)c(C=O)c1O InChI=1S/C17H15N3O6/c1-9-15(24)13(8-21)12(6-7-14(22)23)16(18-9)20-19-11-4-2-10(3-5-11)17(25)26/h2-5,8,24H,6-7H2,1H3,(H,22,23)(H,25,26) UWCDFHGYLDKCRS-UHFFFAOYSA-N 50433071 CHEMBL2376118 P2X purinoceptor 3 Homo sapiens 80 ChEMBL 10.1016/j.bmc.2013.01.073 10.7270/Q2DF6SK7 23510563 Jung, KY; Cho, JH; Lee, JS; Kim, HJ; Kim, YC Gwangju Institute of Science and Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50433071 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50433071&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 51031015 175445388 CHEMBL2376118 ZINC96258387 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51061579 Cc1nc(N=Nc2cc(ccc2S(O)(=O)=O)S(O)(=O)=O)c(CCC(O)=O)c(C=O)c1O InChI=1S/C16H15N3O10S2/c1-8-15(23)11(7-20)10(3-5-14(21)22)16(17-8)19-18-12-6-9(30(24,25)26)2-4-13(12)31(27,28)29/h2,4,6-7,23H,3,5H2,1H3,(H,21,22)(H,24,25,26)(H,27,28,29) DRLAZBVZFMPCLR-UHFFFAOYSA-N 50433072 CHEMBL2376126 P2X purinoceptor 3 Homo sapiens 106 ChEMBL 10.1016/j.bmc.2013.01.073 10.7270/Q2DF6SK7 23510563 Jung, KY; Cho, JH; Lee, JS; Kim, HJ; Kim, YC Gwangju Institute of Science and Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50433072 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50433072&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 54590848 175445389 CHEMBL2376126 ZINC96258389 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51061580 Cc1nc(N=Nc2cc(ccc2S(O)(=O)=O)S(O)(=O)=O)c(COP(O)(O)=O)c(C=O)c1O InChI=1S/C14H14N3O12PS2/c1-7-13(19)9(5-18)10(6-29-30(20,21)22)14(15-7)17-16-11-4-8(31(23,24)25)2-3-12(11)32(26,27)28/h2-5,19H,6H2,1H3,(H2,20,21,22)(H,23,24,25)(H,26,27,28) XYBQYEJAMIDMPT-UHFFFAOYSA-N 50064800 2-(4-Formyl-5-hydroxy-6-methyl-3-phosphonooxymethyl-pyridin-2-ylazo)-benzene-1,4-disulfonic acid::CHEMBL69727::isoPPADS::pyridoxal-alpha5-phosphate-6-azophenyl-2',5'-disulfonic acid P2X purinoceptor 3 Homo sapiens 96 ChEMBL 10.1016/j.bmc.2013.01.073 10.7270/Q2DF6SK7 23510563 Jung, KY; Cho, JH; Lee, JS; Kim, HJ; Kim, YC Gwangju Institute of Science and Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50064800 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50064800&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 5975975 103959755 CHEMBL69727 ZINC03995672 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504732 CCOC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(OC[C@@H](C)CC)cc2)n(Cc2ccc(C)cc2)c1=O 265180 US9718790, I-1051 P2X purinoceptor 3 Homo sapiens 100.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265180 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265180&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278219 377004056 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504733 COC(=O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(OC)nc3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H22ClN5O6/c1-35-21-12-11-20(13-27-21)37-19-9-7-18(8-10-19)28-23-29-24(33)31(15-22(32)36-2)25(34)30(23)14-16-3-5-17(26)6-4-16/h3-13H,14-15H2,1-2H3,(H,28,29,33) NRPOVDYHNGEZGF-UHFFFAOYSA-N 265181 US9718790, I-1753 P2X purinoceptor 3 Homo sapiens 9.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265181 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265181&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945283 377004057 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504734 CC(C)Oc1ccc(Nc2nc(=O)n(CCN3C(=O)CNC3=O)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C24H24ClFN6O5/c1-14(2)37-19-8-7-17(11-18(19)26)28-21-29-23(35)31(10-9-30-20(33)12-27-22(30)34)24(36)32(21)13-15-3-5-16(25)6-4-15/h3-8,11,14H,9-10,12-13H2,1-2H3,(H,27,34)(H,28,29,35) VXBIJNZVTIYGOG-UHFFFAOYSA-N 183224 US9150546, I-391::US9688643, I-391::US9718790, I-0391 P2X purinoceptor 3 Homo sapiens 133 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183224 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183224&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821069 313634624 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504735 CCC[C@H](C)Oc1ccc(cc1)\N=c1/[nH]c(=O)n(CCC(=O)OCC)c(=O)n1Cc1ccc(C)cc1 265183 US9718790, I-1052 P2X purinoceptor 3 Homo sapiens 19.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265183 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265183&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278297 377004059 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504736 COC(=O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccnc(C)c3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H22ClN5O5/c1-16-13-21(11-12-27-16)36-20-9-7-19(8-10-20)28-23-29-24(33)31(15-22(32)35-2)25(34)30(23)14-17-3-5-18(26)6-4-17/h3-13H,14-15H2,1-2H3,(H,28,29,33) QXYWUUPUKKPQAQ-UHFFFAOYSA-N 265184 US9718790, I-1754 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265184 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265184&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020548 377004060 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504737 CC(C)Oc1ccc(Nc2nc(=O)n(CCNC(=O)NCC(O)=O)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C24H26ClFN6O6/c1-14(2)38-19-8-7-17(11-18(19)26)29-21-30-23(36)31(10-9-27-22(35)28-12-20(33)34)24(37)32(21)13-15-3-5-16(25)6-4-15/h3-8,11,14H,9-10,12-13H2,1-2H3,(H,33,34)(H2,27,28,35)(H,29,30,36) DNZVQLZWGVMZRF-UHFFFAOYSA-N 183225 US9150546, I-392::US9688643, I-392::US9718790, I-0392 P2X purinoceptor 3 Homo sapiens 38.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183225 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183225&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 77388921 313634625 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504738 CCC[C@@H](C)Oc1ccc(cc1)\N=c1/[nH]c(=O)n(CCC(=O)OCC)c(=O)n1Cc1ccc(C)cc1 265186 US9718790, I-1053 P2X purinoceptor 3 Homo sapiens 79.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265186 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265186&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945292 377004062 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504739 Cc1cc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(CCO)c(=O)n2Cc2ccc(Cl)cc2)no1 InChI=1S/C22H20ClN5O5/c1-14-12-19(26-33-14)32-18-8-6-17(7-9-18)24-20-25-21(30)27(10-11-29)22(31)28(20)13-15-2-4-16(23)5-3-15/h2-9,12,29H,10-11,13H2,1H3,(H,24,25,30) KTOGQPAWYLPEIH-UHFFFAOYSA-N 265187 US9718790, I-1756 P2X purinoceptor 3 Homo sapiens 30.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265187 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265187&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278203 377004063 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504740 CC(C)Oc1ccc(Nc2nc(=O)n(C(C)C)c(=O)n2Cc2ccc(Cl)cc2)cn1 InChI=1S/C21H24ClN5O3/c1-13(2)27-20(28)25-19(24-17-9-10-18(23-11-17)30-14(3)4)26(21(27)29)12-15-5-7-16(22)8-6-15/h5-11,13-14H,12H2,1-4H3,(H,24,25,28) ADLQECFGSXQFRO-UHFFFAOYSA-N 183226 US9150546, I-394::US9688643, I-394::US9718790, I-0394 P2X purinoceptor 3 Homo sapiens 435 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183226 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183226&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821185 313634626 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504741 CCOC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(OC(CC)CC)cc2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C27H34N4O5/c1-5-22(6-2)36-23-14-12-21(13-15-23)28-25-29-26(33)30(17-16-24(32)35-7-3)27(34)31(25)18-20-10-8-19(4)9-11-20/h8-15,22H,5-7,16-18H2,1-4H3,(H,28,29,33) JOTFEHSUHTUVBL-UHFFFAOYSA-N 265189 US9718790, I-1054 P2X purinoceptor 3 Homo sapiens 18.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265189 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265189&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278220 377004065 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504742 Cc1cc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(C[C@H](O)CO)c(=O)n2Cc2ccc(Cl)cc2)no1 265190 US9718790, I-1757 P2X purinoceptor 3 Homo sapiens 12.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265190 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265190&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278204 377004066 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504743 COC(=O)CNC(=O)Cn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H25ClFN5O6/c1-14(2)37-19-9-8-17(10-18(19)26)28-22-29-23(34)31(13-20(32)27-11-21(33)36-3)24(35)30(22)12-15-4-6-16(25)7-5-15/h4-10,14H,11-13H2,1-3H3,(H,27,32)(H,28,29,34) RNYCCLDACFSVPF-UHFFFAOYSA-N 183227 US9150546, I-397::US9688643, I-397::US9718790, I-0396 P2X purinoceptor 3 Homo sapiens 19.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183227 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183227&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 70645186 313634627 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504744 CCOC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(OCCC(C)C)cc2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C27H34N4O5/c1-5-35-24(32)14-16-30-26(33)29-25(31(27(30)34)18-21-8-6-20(4)7-9-21)28-22-10-12-23(13-11-22)36-17-15-19(2)3/h6-13,19H,5,14-18H2,1-4H3,(H,28,29,33) WJCHZPSRZSBTKC-UHFFFAOYSA-N 265192 US9718790, I-1055 P2X purinoceptor 3 Homo sapiens 91.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265192 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265192&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278298 377004068 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504745 COC(=O)CCn1c(=O)[nH]\c(=N/C2CCC(C)CC2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C22H30N4O4/c1-15-4-8-17(9-5-15)14-26-20(23-18-10-6-16(2)7-11-18)24-21(28)25(22(26)29)13-12-19(27)30-3/h4-5,8-9,16,18H,6-7,10-14H2,1-3H3,(H,23,24,28) XOCIRPDBZMWWLE-UHFFFAOYSA-N 265193 US9718790, I-1759 P2X purinoceptor 3 Homo sapiens 408 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265193 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265193&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020545 377004069 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504746 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n(CC(=O)NC(CO)CO)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C24H27ClFN5O6/c1-14(2)37-20-8-7-17(9-19(20)26)28-22-29-23(35)31(11-21(34)27-18(12-32)13-33)24(36)30(22)10-15-3-5-16(25)6-4-15/h3-9,14,18,32-33H,10-13H2,1-2H3,(H,27,34)(H,28,29,35) QLEUXCJJSFSQEI-UHFFFAOYSA-N 183228 US9150546, I-398::US9688643, I-398::US9718790, I-0397 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183228 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183228&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 70645174 313634628 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504747 CCOC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(OCC(C)(C)C)cc2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C27H34N4O5/c1-6-35-23(32)15-16-30-25(33)29-24(31(26(30)34)17-20-9-7-19(2)8-10-20)28-21-11-13-22(14-12-21)36-18-27(3,4)5/h7-14H,6,15-18H2,1-5H3,(H,28,29,33) ZRISCUVQHGBGBH-UHFFFAOYSA-N 265195 US9718790, I-1056 P2X purinoceptor 3 Homo sapiens 177 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265195 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265195&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019556 377004071 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504748 COc1ccc(COc2cc(Cn3c(=O)[nH]\c(=N/c4ccc(OC(C)C)c(F)c4)n(Cc4ccc(Cl)cc4)c3=O)on2)cc1 InChI=1S/C31H29ClFN5O6/c1-19(2)43-27-13-10-23(14-26(27)33)34-29-35-30(39)38(31(40)37(29)16-20-4-8-22(32)9-5-20)17-25-15-28(36-44-25)42-18-21-6-11-24(41-3)12-7-21/h4-15,19H,16-18H2,1-3H3,(H,34,35,39) OBFUBZVPRSGVPS-UHFFFAOYSA-N 265196 US9718790, I-1764 P2X purinoceptor 3 Homo sapiens 35.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265196 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265196&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278552 377004072 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504749 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(Cl)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H28Cl2N4O5/c1-15(2)36-20-11-10-18(12-19(20)27)28-22-29-23(33)31(14-25(3,4)21(32)35-5)24(34)30(22)13-16-6-8-17(26)9-7-16/h6-12,15H,13-14H2,1-5H3,(H,28,29,33) NEGZBMXAYHSDHD-UHFFFAOYSA-N 183229 US9150546, I-399::US9688643, I-399::US9718790, I-0398 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183229 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183229&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578721 313634629 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504750 CCCCCOc1ccc(cc1)\N=c1/[nH]c(=O)n(C[C@H](C)C(=O)OC)c(=O)n1Cc1ccc(C)cc1 265198 US9718790, I-1057 P2X purinoceptor 3 Homo sapiens 89.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265198 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265198&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278305 377004074 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504751 CCc1cc2cc(ccc2o1)\N=c1/[nH]c(=O)n(C[C@H](C)C(=O)OC)c(=O)n1Cc1ccc(Cl)cc1 265199 US9718790, I-1765 P2X purinoceptor 3 Homo sapiens 9.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265199 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265199&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021003 377004075 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504752 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n(CC(=O)NCC(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C23H23ClFN5O6/c1-13(2)36-18-8-7-16(9-17(18)25)27-21-28-22(34)30(12-19(31)26-10-20(32)33)23(35)29(21)11-14-3-5-15(24)6-4-14/h3-9,13H,10-12H2,1-2H3,(H,26,31)(H,32,33)(H,27,28,34) YMEDLYRRZUJVPG-UHFFFAOYSA-N 183230 US9150546, I-400::US9688643, I-400::US9718790, I-0399 P2X purinoceptor 3 Homo sapiens 44.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183230 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183230&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 70645141 313634630 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504753 CCCCCOc1ccc(cc1)\N=c1/[nH]c(=O)n(CCC(=O)OCC)c(=O)n1Cc1ccc(C)cc1 InChI=1S/C27H34N4O5/c1-4-6-7-18-36-23-14-12-22(13-15-23)28-25-29-26(33)30(17-16-24(32)35-5-2)27(34)31(25)19-21-10-8-20(3)9-11-21/h8-15H,4-7,16-19H2,1-3H3,(H,28,29,33) BKZMZPAJYGIRQV-UHFFFAOYSA-N 265201 US9718790, I-1058 P2X purinoceptor 3 Homo sapiens 43.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265201 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265201&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019528 377004077 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504754 CCc1cc2cc(ccc2o1)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 265202 US9718790, I-1766 P2X purinoceptor 3 Homo sapiens 18.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265202 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265202&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020494 377004078 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504755 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C24H26Cl2N4O5/c1-14(2)35-19-10-9-17(11-18(19)26)27-21-28-22(33)30(13-24(3,4)20(31)32)23(34)29(21)12-15-5-7-16(25)8-6-15/h5-11,14H,12-13H2,1-4H3,(H,31,32)(H,27,28,33) JBUWYWPQCDLCBD-UHFFFAOYSA-N 183231 US9150546, I-401::US9688643, I-401::US9718790, I-0400 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183231 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183231&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578683 313634631 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504756 CC[C@H](C)COc1ccc(cc1)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(C)cc1 265204 US9718790, I-1059 P2X purinoceptor 3 Homo sapiens 123 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265204 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265204&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278299 377004080 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504757 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n(Cc2cc(O)no2)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C23H21ClFN5O5/c1-13(2)34-19-8-7-16(9-18(19)25)26-21-27-22(32)30(12-17-10-20(31)28-35-17)23(33)29(21)11-14-3-5-15(24)6-4-14/h3-10,13H,11-12H2,1-2H3,(H,28,31)(H,26,27,32) LEPLQRFIYIVXPA-UHFFFAOYSA-N 265205 US9718790, I-1767 P2X purinoceptor 3 Homo sapiens 55.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265205 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265205&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278287 377004081 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504758 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(cc2)C(=O)C(C)(C)C)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C27H31ClN4O5/c1-26(2,3)21(33)18-9-13-20(14-10-18)29-23-30-24(35)32(16-27(4,5)22(34)37-6)25(36)31(23)15-17-7-11-19(28)12-8-17/h7-14H,15-16H2,1-6H3,(H,29,30,35) SNQFHIXRJZIARK-UHFFFAOYSA-N 183232 US9150546, I-402::US9688643, I-402::US9718790, I-0401 P2X purinoceptor 3 Homo sapiens 443 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183232 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183232&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578510 313634632 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504759 CCC[C@H](C)Oc1ccc(cc1)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(C)cc1 265207 US9718790, I-1060 P2X purinoceptor 3 Homo sapiens 29.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265207 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265207&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019557 377004083 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504760 CCc1nc2ccc(cc2s1)\N=c1/[nH]c(=O)n(CCC(N)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C22H21ClN6O3S/c1-2-19-26-16-8-7-15(11-17(16)33-19)25-20-27-21(31)28(10-9-18(24)30)22(32)29(20)12-13-3-5-14(23)6-4-13/h3-8,11H,2,9-10,12H2,1H3,(H2,24,30)(H,25,27,31) ILSSNYMJWBQBNX-UHFFFAOYSA-N 265208 US9718790, I-1768 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265208 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265208&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020524 377004084 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504761 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H28ClFN4O5/c1-15(2)36-20-11-10-18(12-19(20)27)28-22-29-23(33)31(14-25(3,4)21(32)35-5)24(34)30(22)13-16-6-8-17(26)9-7-16/h6-12,15H,13-14H2,1-5H3,(H,28,29,33) HZQKRSDENBOLOY-UHFFFAOYSA-N 183233 US9150546, I-403::US9688643, I-403::US9718790, I-0402 P2X purinoceptor 3 Homo sapiens 15.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183233 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183233&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578492 313634633 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504762 CCC[C@@H](C)Oc1ccc(cc1)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(C)cc1 265210 US9718790, I-1061 P2X purinoceptor 3 Homo sapiens 174 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265210 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265210&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945413 377004086 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504763 CCc1nc2ccc(cc2s1)\N=c1/[nH]c(=O)n(CCC#N)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C22H19ClN6O2S/c1-2-19-26-17-9-8-16(12-18(17)32-19)25-20-27-21(30)28(11-3-10-24)22(31)29(20)13-14-4-6-15(23)7-5-14/h4-9,12H,2-3,11,13H2,1H3,(H,25,27,30) RHOUGELXGYSCHW-UHFFFAOYSA-N 265211 US9718790, I-1769 P2X purinoceptor 3 Homo sapiens 3.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265211 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265211&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020526 377004087 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504764 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(F)c2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C26H31FN4O5/c1-16(2)36-21-12-11-19(13-20(21)27)28-23-29-24(33)31(15-26(4,5)22(32)35-6)25(34)30(23)14-18-9-7-17(3)8-10-18/h7-13,16H,14-15H2,1-6H3,(H,28,29,33) MRSBPJQMAXBIJN-UHFFFAOYSA-N 183234 US9150546, I-404::US9688643, I-404::US9718790, I-0403 P2X purinoceptor 3 Homo sapiens 12.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183234 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183234&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578473 313634634 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504765 CCC(CC)Oc1ccc(cc1)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(C)cc1 265213 US9718790, I-1062 P2X purinoceptor 3 Homo sapiens 37.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265213 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265213&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945051 377004089 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504766 CC(C)n1c2CCCCc2c2cc(ccc12)\N=c1/[nH]c(=O)n([C@@H](C)[C@@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 265214 US9718790, I-1770 P2X purinoceptor 3 Homo sapiens 788 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265214 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265214&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278553 377004090 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504767 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n1Cc1ccc(C)cc1 InChI=1S/C25H29FN4O5/c1-15(2)35-20-11-10-18(12-19(20)26)27-22-28-23(33)30(14-25(4,5)21(31)32)24(34)29(22)13-17-8-6-16(3)7-9-17/h6-12,15H,13-14H2,1-5H3,(H,31,32)(H,27,28,33) LJWOBZNJMCMRLJ-UHFFFAOYSA-N 183235 US9150546, I-405::US9688643, I-405::US9718790, I-0404 P2X purinoceptor 3 Homo sapiens 32.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183235 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183235&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578628 313634635 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504768 CC(C)CCOc1ccc(cc1)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(C)cc1 265216 US9718790, I-1063 P2X purinoceptor 3 Homo sapiens 152 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265216 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265216&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278548 377004092 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504769 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc3[nH]c(C)c(C)c3c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O InChI=1S/C25H24ClN5O4/c1-13-15(3)27-21-10-9-19(11-20(13)21)28-23-29-24(34)31(16(4)14(2)22(32)33)25(35)30(23)12-17-5-7-18(26)8-6-17/h5-11,14,16H,12H2,1-4H3,(H,32,33)/b28-19+/t14-,16+/m1/s1 MLGQZBKBPRPNET-OLJVEPJOSA-N 265217 US9718790, I-1771 P2X purinoceptor 3 Homo sapiens 14.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265217 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265217&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020502 377004093 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504770 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n(CCC(C)(C)C(=O)OCc2ccccc2)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C32H34ClFN4O5/c1-21(2)43-27-15-14-25(18-26(27)34)35-29-36-30(40)37(31(41)38(29)19-22-10-12-24(33)13-11-22)17-16-32(3,4)28(39)42-20-23-8-6-5-7-9-23/h5-15,18,21H,16-17,19-20H2,1-4H3,(H,35,36,40) TUOYSYBZHUPNQN-UHFFFAOYSA-N 183236 US9150546, I-406::US9688643, I-406::US9718790, I-0405 P2X purinoceptor 3 Homo sapiens 30.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183236 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183236&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578501 313634636 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504771 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(OCC(C)(C)C)cc2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 265219 US9718790, I-1064 P2X purinoceptor 3 Homo sapiens 257 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265219 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265219&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278174 377004095 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504772 CC(C)n1cnc2cc(ccc12)\N=c1/[nH]c(=O)n([C@@H](C)[C@@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 265220 US9718790, I-1772 P2X purinoceptor 3 Homo sapiens 297 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265220 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265220&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278598 377004096 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504773 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(CCC(C)(C)C(=O)OCc2ccccc2)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C32H34Cl2N4O5/c1-21(2)43-27-15-14-25(18-26(27)34)35-29-36-30(40)37(31(41)38(29)19-22-10-12-24(33)13-11-22)17-16-32(3,4)28(39)42-20-23-8-6-5-7-9-23/h5-15,18,21H,16-17,19-20H2,1-4H3,(H,35,36,40) OOPDFVLJBFXGIN-UHFFFAOYSA-N 183237 US9150546, I-407::US9688643, I-407::US9718790, I-0406 P2X purinoceptor 3 Homo sapiens 27.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183237 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183237&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578925 313634637 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504774 CCCCCOc1ccc(cc1)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(C)cc1 265222 US9718790, I-1065 P2X purinoceptor 3 Homo sapiens 85.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265222 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265222&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278175 377004098 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504775 COc1ccc2cc(ccc2c1)\N=c1/[nH]c(=O)n([C@@H](C)[C@@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 265223 US9718790, I-1773 P2X purinoceptor 3 Homo sapiens 29.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265223 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265223&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278554 377004099 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504776 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n1Cc1ccc(C)cc1 InChI=1S/C25H29ClN4O5/c1-15(2)35-20-11-10-18(12-19(20)26)27-22-28-23(33)30(14-25(4,5)21(31)32)24(34)29(22)13-17-8-6-16(3)7-9-17/h6-12,15H,13-14H2,1-5H3,(H,31,32)(H,27,28,33) IEFCYNPWRFXORF-UHFFFAOYSA-N 183238 US9150546, I-408::US9688643, I-408::US9718790, I-0407 P2X purinoceptor 3 Homo sapiens 10.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183238 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183238&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578596 313634638 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504777 CC[C@H](C)COc1ccc(cc1)\N=c1/[nH]c(=O)n(CCC(O)=O)c(=O)n1Cc1ccc(C)cc1 265225 US9718790, I-1066 P2X purinoceptor 3 Homo sapiens 425 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265225 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265225&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945351 377004101 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504778 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc3N(CCc3c2)S(C)(=O)=O)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 265226 US9718790, I-1774 P2X purinoceptor 3 Homo sapiens 255 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265226 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265226&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278365 377004102 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504779 COC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(F)c2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C24H27FN4O5/c1-15(2)34-20-10-9-18(13-19(20)25)26-22-27-23(31)28(12-11-21(30)33-4)24(32)29(22)14-17-7-5-16(3)6-8-17/h5-10,13,15H,11-12,14H2,1-4H3,(H,26,27,31) PHPQOSGTOXGNRQ-UHFFFAOYSA-N 183239 US9150546, I-409::US9688643, I-409::US9718790, I-0408 P2X purinoceptor 3 Homo sapiens 12.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183239 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183239&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578582 313634639 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504780 CCC[C@H](C)Oc1ccc(cc1)\N=c1/[nH]c(=O)n(CCC(O)=O)c(=O)n1Cc1ccc(C)cc1 265228 US9718790, I-1067 P2X purinoceptor 3 Homo sapiens 93.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265228 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265228&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945415 377004104 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504781 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc3\C(CCc3c2)=N\O)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 265229 US9718790, I-1777 P2X purinoceptor 3 Homo sapiens 636 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265229 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265229&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278366 377004105 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504782 COC(=O)Cn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(F)c2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C23H25FN4O5/c1-14(2)33-19-10-9-17(11-18(19)24)25-21-26-22(30)28(13-20(29)32-4)23(31)27(21)12-16-7-5-15(3)6-8-16/h5-11,14H,12-13H2,1-4H3,(H,25,26,30) WSLNIUFYXOOLNG-UHFFFAOYSA-N 183240 US9150546, I-410::US9688643, I-410::US9718790, I-0409 P2X purinoceptor 3 Homo sapiens 44.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183240 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183240&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578811 313634640 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504783 CCC[C@@H](C)Oc1ccc(cc1)\N=c1/[nH]c(=O)n(CCC(O)O)c(=O)n1Cc1ccc(C)cc1 265231 US9718790, I-1068 P2X purinoceptor 3 Homo sapiens 541 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265231 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265231&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278176 377004107 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504784 CC(C)N1C(=O)Cc2cc(ccc12)\N=c1/[nH]c(=O)n([C@@H](C)[C@@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 265232 US9718790, I-1779 P2X purinoceptor 3 Homo sapiens 203 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265232 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265232&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278291 377004108 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504785 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n(CCC(O)=O)c(=O)n1Cc1ccc(C)cc1 InChI=1S/C23H25FN4O5/c1-14(2)33-19-9-8-17(12-18(19)24)25-21-26-22(31)27(11-10-20(29)30)23(32)28(21)13-16-6-4-15(3)5-7-16/h4-9,12,14H,10-11,13H2,1-3H3,(H,29,30)(H,25,26,31) ISLQRXSYZCSMAZ-UHFFFAOYSA-N 183241 US9150546, I-411::US9688643, I-411::US9718790, I-0410 P2X purinoceptor 3 Homo sapiens 61.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183241 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183241&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578680 313634641 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504786 CCC(CC)Oc1ccc(cc1)\N=c1/[nH]c(=O)n(CCC(O)=O)c(=O)n1Cc1ccc(C)cc1 InChI=1S/C25H30N4O5/c1-4-20(5-2)34-21-12-10-19(11-13-21)26-23-27-24(32)28(15-14-22(30)31)25(33)29(23)16-18-8-6-17(3)7-9-18/h6-13,20H,4-5,14-16H2,1-3H3,(H,30,31)(H,26,27,32) HJZUBNSIGSEIKD-UHFFFAOYSA-N 265234 US9718790, I-1069 P2X purinoceptor 3 Homo sapiens 111 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265234 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265234&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278306 377004109 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504787 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc3n(CC(F)(F)F)c(=O)sc3c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 265235 US9718790, I-1780 P2X purinoceptor 3 Homo sapiens 932 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265235 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265235&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278292 377004110 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504788 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n1Cc1ccc(C)c(F)c1 InChI=1S/C25H28F2N4O5/c1-14(2)36-20-9-8-17(11-19(20)27)28-22-29-23(34)31(13-25(4,5)21(32)33)24(35)30(22)12-16-7-6-15(3)18(26)10-16/h6-11,14H,12-13H2,1-5H3,(H,32,33)(H,28,29,34) IBIXQPAHELGEQO-UHFFFAOYSA-N 183242 US9150546, I-413::US9688643, I-413::US9718790, I-0412 P2X purinoceptor 3 Homo sapiens 99.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183242 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183242&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578614 313634642 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504789 CC(C)CCOc1ccc(cc1)\N=c1/[nH]c(=O)n(CCC(O)=O)c(=O)n1Cc1ccc(C)cc1 InChI=1S/C25H30N4O5/c1-17(2)13-15-34-21-10-8-20(9-11-21)26-23-27-24(32)28(14-12-22(30)31)25(33)29(23)16-19-6-4-18(3)5-7-19/h4-11,17H,12-16H2,1-3H3,(H,30,31)(H,26,27,32) BXIBOCCPOYSWJW-UHFFFAOYSA-N 265237 US9718790, I-1070 P2X purinoceptor 3 Homo sapiens 471 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265237 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265237&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278487 377004112 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504790 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc3[nH]ccc3c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O InChI=1S/C23H20ClN5O4/c1-13(20(30)31)14(2)29-22(32)27-21(26-18-7-8-19-16(11-18)9-10-25-19)28(23(29)33)12-15-3-5-17(24)6-4-15/h3-11,13-14H,12H2,1-2H3,(H,30,31)/b26-18+/t13-,14+/m1/s1 WAFAYQGHTGXQOI-WLKQNIQWSA-N 265238 US9718790, I-1781 P2X purinoceptor 3 Homo sapiens 518 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265238 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265238&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020536 377004113 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504791 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n(CC(=O)NC(CO)CO)c(=O)n1Cc1ccc(C)cc1 InChI=1S/C25H30FN5O6/c1-15(2)37-21-9-8-18(10-20(21)26)28-23-29-24(35)31(12-22(34)27-19(13-32)14-33)25(36)30(23)11-17-6-4-16(3)5-7-17/h4-10,15,19,32-33H,11-14H2,1-3H3,(H,27,34)(H,28,29,35) UEHTZRMWTIRNBJ-UHFFFAOYSA-N 183243 US9150546, I-414::US9688643, I-414::US9718790, I-0413 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183243 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183243&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 70645185 313634643 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504792 Cc1ccc(Cn2c(=O)n(CCC(O)=O)c(=O)[nH]\c2=N/c2ccc(OCC(C)(C)C)cc2)cc1 InChI=1S/C25H30N4O5/c1-17-5-7-18(8-6-17)15-29-22(27-23(32)28(24(29)33)14-13-21(30)31)26-19-9-11-20(12-10-19)34-16-25(2,3)4/h5-12H,13-16H2,1-4H3,(H,30,31)(H,26,27,32) QLGNGCIBUQLXAA-UHFFFAOYSA-N 265240 US9718790, I-1071 P2X purinoceptor 3 Homo sapiens 998 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265240 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265240&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278549 377004115 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504793 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc3OC(F)(F)C(F)(F)Oc3c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 265241 US9718790, I-1783 P2X purinoceptor 3 Homo sapiens 170 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265241 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265241&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278555 377004116 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504794 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n(CC(=O)NC(C)(C)C(O)=O)c(=O)n1Cc1ccc(C)cc1 InChI=1S/C26H30FN5O6/c1-15(2)38-20-11-10-18(12-19(20)27)28-23-29-24(36)32(14-21(33)30-26(4,5)22(34)35)25(37)31(23)13-17-8-6-16(3)7-9-17/h6-12,15H,13-14H2,1-5H3,(H,30,33)(H,34,35)(H,28,29,36) NTTJRMLBZJXKKV-UHFFFAOYSA-N 183244 US9150546, I-415::US9688643, I-415::US9718790, I-0414 P2X purinoceptor 3 Homo sapiens 314 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183244 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183244&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020931 313634644 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504795 CCCCCOc1ccc(cc1)\N=c1/[nH]c(=O)n(CCC(O)=O)c(=O)n1Cc1ccc(C)cc1 InChI=1S/C25H30N4O5/c1-3-4-5-16-34-21-12-10-20(11-13-21)26-23-27-24(32)28(15-14-22(30)31)25(33)29(23)17-19-8-6-18(2)7-9-19/h6-13H,3-5,14-17H2,1-2H3,(H,30,31)(H,26,27,32) FSTUZRGCAFRWRF-UHFFFAOYSA-N 265243 US9718790, I-1072 P2X purinoceptor 3 Homo sapiens 252 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265243 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265243&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278488 377004118 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504796 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc3C(=O)CCCc3c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 265244 US9718790, I-1784 P2X purinoceptor 3 Homo sapiens 950 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265244 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265244&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020538 377004119 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504797 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n(CC(=O)NCC(O)=O)c(=O)n1Cc1ccc(C)cc1 InChI=1S/C24H26FN5O6/c1-14(2)36-19-9-8-17(10-18(19)25)27-22-28-23(34)30(13-20(31)26-11-21(32)33)24(35)29(22)12-16-6-4-15(3)5-7-16/h4-10,14H,11-13H2,1-3H3,(H,26,31)(H,32,33)(H,27,28,34) FEDTXBHBTVGDMW-UHFFFAOYSA-N 183245 US9150546, I-416::US9688643, I-416::US9718790, I-0415 P2X purinoceptor 3 Homo sapiens 35.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183245 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183245&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 70645146 313634645 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505228 CNC(=O)Cn1c(=O)[nH]\c(=N/c2ccc(O[C@H](C)C(F)(F)F)cc2)n(Cc2ccc(Cl)cc2)c1=O 265666 US9718790, I-1960 P2X purinoceptor 3 Homo sapiens 54.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265666 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265666&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021184 377004538 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505229 CC(C)Oc1ccc(cc1C)\N=c1/[nH]c(=O)n([C@H](C)CC(O)=O)c(=O)n1Cc1ccc(Cl)cc1 183389 US9150546, I-563::US9688643, I-563::US9718790, I-0572 P2X purinoceptor 3 Homo sapiens 40.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183389 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183389&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578867 313634789 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505230 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(cc2)N2CCCCCC2)n(Cc2ccc(Cl)cc2)c1=O 265668 US9718790, I-1233 P2X purinoceptor 3 Homo sapiens 325 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265668 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265668&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278319 377004540 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505231 C[C@@H](Oc1ccc(cc1)\N=c1/[nH]c(=O)n(CC(=O)NCC(F)(F)F)c(=O)n1Cc1ccc(Cl)cc1)C(F)(F)F 265669 US9718790, I-1961 P2X purinoceptor 3 Homo sapiens 13.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265669 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265669&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945436 377004541 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505232 C[C@H](Cn1c(=O)[nH]\c(=N/c2ccc3oc(C)cc3c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 183390 US9150546, I-564::US9688643, I-564::US9718790, I-0573 P2X purinoceptor 3 Homo sapiens 48.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183390 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183390&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578819 313634790 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505233 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(cc2)N2CCCCCC2)n(Cc2ccc(C)cc2)c1=O 265671 US9718790, I-1234 P2X purinoceptor 3 Homo sapiens 230 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265671 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265671&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278498 377004543 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505234 OCc1cc(Oc2ccc(cc2)\N=c2/[nH]c(=O)[nH]c(=O)n2Cc2ccc(Cl)cc2)ccn1 InChI=1S/C22H18ClN5O4/c23-15-3-1-14(2-4-15)12-28-20(26-21(30)27-22(28)31)25-16-5-7-18(8-6-16)32-19-9-10-24-17(11-19)13-29/h1-11,29H,12-13H2,(H2,25,26,27,30,31) NOVGHQVZRWILJG-UHFFFAOYSA-N 265672 US9718790, I-1962 P2X purinoceptor 3 Homo sapiens 65.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265672 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265672&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945570 377004544 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505235 CCOC(=O)CCCn1c(=O)[nH]\c(=N/c2ccc3oc(C)cc3c2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C26H28N4O5/c1-4-34-23(31)6-5-13-29-25(32)28-24(27-21-11-12-22-20(15-21)14-18(3)35-22)30(26(29)33)16-19-9-7-17(2)8-10-19/h7-12,14-15H,4-6,13,16H2,1-3H3,(H,27,28,32) QAOPNPIBCQMJAJ-UHFFFAOYSA-N 265673 US9718790, I-0574 P2X purinoceptor 3 Homo sapiens 15.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265673&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578769 377004545 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505236 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(cc2)N2CCCCCC2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 265674 US9718790, I-1235 P2X purinoceptor 3 Homo sapiens 214 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265674 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265674&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945108 377004546 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505237 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cc(on3)C(O)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C22H18ClN5O6/c1-2-27-21(31)25-20(28(22(27)32)12-13-3-5-14(23)6-4-13)24-15-7-9-16(10-8-15)33-18-11-17(19(29)30)34-26-18/h3-11H,2,12H2,1H3,(H,29,30)(H,24,25,31) KMCNCBRAJZVAOI-UHFFFAOYSA-N 265675 US9718790, I-1963 P2X purinoceptor 3 Homo sapiens 13.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265675 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265675&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945277 377004547 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505238 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(nc(=O)n1Cc1ccc(Cl)cc1)N1CCCC1=O InChI=1S/C23H23Cl2N5O3/c1-14(2)33-19-10-9-17(12-18(19)25)26-21-27-22(29-11-3-4-20(29)31)28-23(32)30(21)13-15-5-7-16(24)8-6-15/h5-10,12,14H,3-4,11,13H2,1-2H3,(H,26,27,28,32) AGOKXKCSCRKDNJ-UHFFFAOYSA-N 183391 US9150546, II-012::US9688643, II-012::US9718790, I-0576 P2X purinoceptor 3 Homo sapiens 568 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183391 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183391&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 119099073 313634791 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505239 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(OCC3CC3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H29ClN4O5/c1-26(2,22(32)35-3)16-31-24(33)29-23(30(25(31)34)14-17-6-8-19(27)9-7-17)28-20-10-12-21(13-11-20)36-15-18-4-5-18/h6-13,18H,4-5,14-16H2,1-3H3,(H,28,29,33) DFTCKKGRDYIDGX-UHFFFAOYSA-N 265677 US9718790, I-1236 P2X purinoceptor 3 Homo sapiens 13.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265677 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265677&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278233 377004549 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505240 CCc1cc2cc(ccc2s1)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 265678 US9718790, I-1964 P2X purinoceptor 3 Homo sapiens 277 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265678 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265678&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020988 377004550 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505241 CCN(CC)c1nc(=O)n(Cc2ccc(Cl)cc2)\c(=N\c2ccc(OC(C)C)c(Cl)c2)[nH]1 InChI=1S/C23H27Cl2N5O2/c1-5-29(6-2)21-27-22(26-18-11-12-20(19(25)13-18)32-15(3)4)30(23(31)28-21)14-16-7-9-17(24)10-8-16/h7-13,15H,5-6,14H2,1-4H3,(H,26,27,28,31) QIYDVXQPYHCHGL-UHFFFAOYSA-N 183392 US9150546, II-013::US9688643, II-013::US9718790, I-0577 P2X purinoceptor 3 Homo sapiens 430 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183392 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183392&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 119099074 313634792 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505242 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(cc2)N2CCCCCC2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 265680 US9718790, I-1237 P2X purinoceptor 3 Homo sapiens 183 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265680 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265680&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020121 377004552 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505243 CC1(C)OCC(Cn2c(=O)[nH]\c(=N/c3ccc(OC4CCC4)cc3)n(Cc3ccc(Cl)cc3)c2=O)CO1 InChI=1S/C27H31ClN4O5/c1-27(2)35-16-19(17-36-27)15-32-25(33)30-24(31(26(32)34)14-18-6-8-20(28)9-7-18)29-21-10-12-23(13-11-21)37-22-4-3-5-22/h6-13,19,22H,3-5,14-17H2,1-2H3,(H,29,30,33) LPDIXRUKJXSOTM-UHFFFAOYSA-N 265681 US9718790, I-1965 P2X purinoceptor 3 Homo sapiens 3.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265681 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265681&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020989 377004553 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505244 CCOc1nc(=O)n(Cc2ccc(Cl)cc2)\c(=N\c2ccc(OC(C)C)c(Cl)c2)[nH]1 InChI=1S/C21H22Cl2N4O3/c1-4-29-20-25-19(24-16-9-10-18(17(23)11-16)30-13(2)3)27(21(28)26-20)12-14-5-7-15(22)8-6-14/h5-11,13H,4,12H2,1-3H3,(H,24,25,26,28) INJXKGYCADCMNE-UHFFFAOYSA-N 183393 US9150546, II-014::US9688643, II-014::US9718790, I-0578 P2X purinoceptor 3 Homo sapiens 254 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183393 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183393&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 119099075 313634793 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505245 CCOC(=O)CCCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccncc3)cc2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C28H29N5O5/c1-3-37-25(34)5-4-18-32-27(35)31-26(33(28(32)36)19-21-8-6-20(2)7-9-21)30-22-10-12-23(13-11-22)38-24-14-16-29-17-15-24/h6-17H,3-5,18-19H2,1-2H3,(H,30,31,35) KGRFQCAZSNJDSQ-UHFFFAOYSA-N 265683 US9718790, I-1238 P2X purinoceptor 3 Homo sapiens 2.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265683 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265683&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020032 377004555 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505246 Cc1[nH]c2ccc(cc2c1C)\N=c1/[nH]c(=O)n(CCC(N)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C23H23ClN6O3/c1-13-14(2)26-19-8-7-17(11-18(13)19)27-21-28-22(32)29(10-9-20(25)31)23(33)30(21)12-15-3-5-16(24)6-4-15/h3-8,11,26H,9-10,12H2,1-2H3,(H2,25,31)(H,27,28,32) XYGPLZPVJAJHME-UHFFFAOYSA-N 265684 US9718790, I-1966 P2X purinoceptor 3 Homo sapiens 11.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265684 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265684&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019809 377004556 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505247 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(CCC(O)=O)nc(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C22H22Cl2N4O4/c1-13(2)32-18-8-7-16(11-17(18)24)25-21-26-19(9-10-20(29)30)27-22(31)28(21)12-14-3-5-15(23)6-4-14/h3-8,11,13H,9-10,12H2,1-2H3,(H,29,30)(H,25,26,27,31) HSAJOPASXWABBQ-UHFFFAOYSA-N 183394 US9150546, II-015::US9688643, II-015::US9718790, I-0579 P2X purinoceptor 3 Homo sapiens 614 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183394 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183394&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 119099076 313634794 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505248 CCOC(=O)CCCn1c(=O)[nH]\c(=N/c2ccc(O)cc2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C23H26N4O5/c1-3-32-20(29)5-4-14-26-22(30)25-21(24-18-10-12-19(28)13-11-18)27(23(26)31)15-17-8-6-16(2)7-9-17/h6-13,28H,3-5,14-15H2,1-2H3,(H,24,25,30) AMRZUDXYNFQDIA-UHFFFAOYSA-N 265686 US9718790, I-1239 P2X purinoceptor 3 Homo sapiens 732 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265686 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265686&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020123 377004558 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505249 CNC(=O)CCn1c(=O)[nH]\c(=N/c2ccc3[nH]c(C)c(C)c3c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H25ClN6O3/c1-14-15(2)27-20-9-8-18(12-19(14)20)28-22-29-23(33)30(11-10-21(32)26-3)24(34)31(22)13-16-4-6-17(25)7-5-16/h4-9,12,27H,10-11,13H2,1-3H3,(H,26,32)(H,28,29,33) LMOHYZIWLAGTIX-UHFFFAOYSA-N 265687 US9718790, I-1967 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265687 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265687&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020005 377004559 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505250 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(OCC(O)=O)nc(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C21H20ClFN4O5/c1-12(2)32-17-8-7-15(9-16(17)23)24-19-25-20(31-11-18(28)29)26-21(30)27(19)10-13-3-5-14(22)6-4-13/h3-9,12H,10-11H2,1-2H3,(H,28,29)(H,24,25,26,30) JSHFFHVRIQTJJK-UHFFFAOYSA-N 265688 US9718790, I-0581 P2X purinoceptor 3 Homo sapiens 145 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265688 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265688&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 135121009 377004560 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505251 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cc(C)nc(C)c3)cc2)n(Cc2ccc(C)cc2)c1=O 265689 US9718790, I-1240 P2X purinoceptor 3 Homo sapiens 18.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265689 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265689&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020196 377004561 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505252 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cc(CO)on3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C22H20ClN5O5/c1-2-27-21(30)25-20(28(22(27)31)12-14-3-5-15(23)6-4-14)24-16-7-9-17(10-8-16)32-19-11-18(13-29)33-26-19/h3-11,29H,2,12-13H2,1H3,(H,24,25,30) FCXJOTGGDGREDG-UHFFFAOYSA-N 265690 US9718790, I-1968 P2X purinoceptor 3 Homo sapiens 15.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265690 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265690&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278619 377004562 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505253 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(OCC(=O)NCCO)nc(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C23H25ClFN5O5/c1-14(2)35-19-8-7-17(11-18(19)25)27-21-28-22(34-13-20(32)26-9-10-31)29-23(33)30(21)12-15-3-5-16(24)6-4-15/h3-8,11,14,31H,9-10,12-13H2,1-2H3,(H,26,32)(H,27,28,29,33) OUZGSYAAQRIMEY-UHFFFAOYSA-N 265691 US9718790, I-0582 P2X purinoceptor 3 Homo sapiens 365 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265691 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265691&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 135121010 377004563 C04080 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505254 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Cc3ccncc3)cc2)n(Cc2ccc(C)cc2)c1=O 265692 US9718790, I-1241 P2X purinoceptor 3 Homo sapiens 108 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265692 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265692&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019606 377004564 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505255 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(cc3)C(O)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H21ClN4O5/c1-2-29-24(33)28-23(30(25(29)34)15-16-3-7-18(26)8-4-16)27-19-9-13-21(14-10-19)35-20-11-5-17(6-12-20)22(31)32/h3-14H,2,15H2,1H3,(H,31,32)(H,27,28,33) ILIZTKMXIBQOCV-UHFFFAOYSA-N 265693 US9718790, I-1969 P2X purinoceptor 3 Homo sapiens 21.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265693 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265693&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019956 377004565 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505256 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(OCC(=O)NN(C)C)nc(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C23H26ClFN6O4/c1-14(2)35-19-10-9-17(11-18(19)25)26-21-27-22(34-13-20(32)29-30(3)4)28-23(33)31(21)12-15-5-7-16(24)8-6-15/h5-11,14H,12-13H2,1-4H3,(H,29,32)(H,26,27,28,33) SWDRSNUJLIVFSW-UHFFFAOYSA-N 265694 US9718790, I-0583 P2X purinoceptor 3 Homo sapiens 38.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265694 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265694&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 135121011 377004566 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505257 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(OCC3CC3)cc2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C27H32N4O5/c1-18-5-7-19(8-6-18)15-30-24(28-21-11-13-22(14-12-21)36-16-20-9-10-20)29-25(33)31(26(30)34)17-27(2,3)23(32)35-4/h5-8,11-14,20H,9-10,15-17H2,1-4H3,(H,28,29,33) GQEBSRAUABGWGJ-UHFFFAOYSA-N 265695 US9718790, I-1242 P2X purinoceptor 3 Homo sapiens 15.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265695 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265695&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945339 377004567 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505258 C[C@H](CO)Cn1c(=O)[nH]\c(=N/c2ccc3oc(CO)cc3c2)n(Cc2ccc(Cl)cc2)c1=O 265696 US9718790, I-1970 P2X purinoceptor 3 Homo sapiens 82.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265696 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265696&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019958 377004568 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505259 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(OCC(=O)NC(CO)CO)nc(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C24H27ClFN5O6/c1-14(2)37-20-8-7-17(9-19(20)26)28-22-29-23(36-13-21(34)27-18(11-32)12-33)30-24(35)31(22)10-15-3-5-16(25)6-4-15/h3-9,14,18,32-33H,10-13H2,1-2H3,(H,27,34)(H,28,29,30,35) YKMDGAIBBUIIMR-UHFFFAOYSA-N 265697 US9718790, I-0584 P2X purinoceptor 3 Homo sapiens 248 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265697 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265697&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 135121012 377004569 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505260 Cc1ccc(Cn2c(=O)n(CCCC(O)=O)c(=O)[nH]\c2=N/c2ccc(Oc3ccncc3)cc2)cc1 InChI=1S/C26H25N5O5/c1-18-4-6-19(7-5-18)17-31-24(29-25(34)30(26(31)35)16-2-3-23(32)33)28-20-8-10-21(11-9-20)36-22-12-14-27-15-13-22/h4-15H,2-3,16-17H2,1H3,(H,32,33)(H,28,29,34) ZGADMCMZPYLKDE-UHFFFAOYSA-N 265698 US9718790, I-1243 P2X purinoceptor 3 Homo sapiens 12.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265698 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265698&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019577 377004570 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505261 CCOC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc3oc(CO)cc3c2)n(Cc2ccc(Cl)cc2)c1=O 265699 US9718790, I-1971 P2X purinoceptor 3 Homo sapiens 61.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265699 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265699&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020527 377004571 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505262 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(OCC(=O)N(C)CCO)nc(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C24H27ClFN5O5/c1-15(2)36-20-9-8-18(12-19(20)26)27-22-28-23(35-14-21(33)30(3)10-11-32)29-24(34)31(22)13-16-4-6-17(25)7-5-16/h4-9,12,15,32H,10-11,13-14H2,1-3H3,(H,27,28,29,34) YOFNEBCGLYRKOI-UHFFFAOYSA-N 265700 US9718790, I-0586 P2X purinoceptor 3 Homo sapiens 611 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265700 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265700&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 135121013 377004572 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505263 COc1cc(ccc1Br)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(C)cc1 265701 US9718790, I-1244 P2X purinoceptor 3 Homo sapiens 473 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265701 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265701&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019691 377004573 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505264 CCOCc1cc2cc(ccc2o1)\N=c1/[nH]c(=O)n(C[C@H](C)CO)c(=O)n1Cc1ccc(Cl)cc1 265702 US9718790, I-1972 P2X purinoceptor 3 Homo sapiens 243 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265702 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265702&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278311 377004574 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505265 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(OCC(N)=O)nc(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C21H21ClFN5O4/c1-12(2)32-17-8-7-15(9-16(17)23)25-19-26-20(31-11-18(24)29)27-21(30)28(19)10-13-3-5-14(22)6-4-13/h3-9,12H,10-11H2,1-2H3,(H2,24,29)(H,25,26,27,30) UCSHWYVKFUMEMW-UHFFFAOYSA-N 265703 US9718790, I-0587 P2X purinoceptor 3 Homo sapiens 299 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265703 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265703&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 135121014 377004575 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505266 COC(=O)CCCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccncc3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H24ClN5O5/c1-36-23(33)3-2-16-31-25(34)30-24(32(26(31)35)17-18-4-6-19(27)7-5-18)29-20-8-10-21(11-9-20)37-22-12-14-28-15-13-22/h4-15H,2-3,16-17H2,1H3,(H,29,30,34) HOWSVCXXLNTARV-UHFFFAOYSA-N 265704 US9718790, I-1245 P2X purinoceptor 3 Homo sapiens 3.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265704 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265704&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019607 377004576 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505267 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(cc3)-c3ncn[nH]3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H22ClN7O3/c1-2-33-25(35)31-24(34(26(33)36)15-17-3-7-19(27)8-4-17)30-20-9-13-22(14-10-20)37-21-11-5-18(6-12-21)23-28-16-29-32-23/h3-14,16H,2,15H2,1H3,(H,28,29,32)(H,30,31,35) KRCHSRSVJSOCOQ-UHFFFAOYSA-N 265705 US9718790, I-1973 P2X purinoceptor 3 Homo sapiens 2.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265705 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265705&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278413 377004577 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505268 COC(=O)[C@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O 265706 US9718790, I-0589 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265706 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265706&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118944966 377004578 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505269 CCOC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(OC)c2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C26H32N4O6/c1-6-35-23(31)13-14-29-25(32)28-24(30(26(29)33)16-19-9-7-18(4)8-10-19)27-20-11-12-21(36-17(2)3)22(15-20)34-5/h7-12,15,17H,6,13-14,16H2,1-5H3,(H,27,28,32) WJLQQINWORTDRK-UHFFFAOYSA-N 265707 US9718790, I-1246 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265707 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265707&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019915 377004579 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505270 OCC(CO)Cn1c(=O)[nH]\c(=N/c2ccc(OC3CCC3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H27ClN4O5/c25-18-6-4-16(5-7-18)12-28-22(27-23(32)29(24(28)33)13-17(14-30)15-31)26-19-8-10-21(11-9-19)34-20-2-1-3-20/h4-11,17,20,30-31H,1-3,12-15H2,(H,26,27,32) OSMRZLCFTXMGPA-UHFFFAOYSA-N 265708 US9718790, I-1974 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265708 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265708&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020572 377004580 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505271 CCOc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(C[C@@H](C)C(=O)OC)c(=O)n1Cc1ccc(Cl)cc1 265709 US9718790, I-0590 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265709 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265709&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020101 377004581 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505272 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(CC(C)C)c(OC)c2)n(Cc2ccc(Cl)cc2)c1=O 265710 US9718790, I-1247 P2X purinoceptor 3 Homo sapiens 28.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265710 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265710&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019936 377004582 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505273 CC1CCC(Cn2c(=O)n(CCC(O)=O)c(=O)[nH]\c2=N/c2ccc(Oc3ccnc(C)c3)cc2)CC1 InChI=1S/C26H31N5O5/c1-17-3-5-19(6-4-17)16-31-24(29-25(34)30(26(31)35)14-12-23(32)33)28-20-7-9-21(10-8-20)36-22-11-13-27-18(2)15-22/h7-11,13,15,17,19H,3-6,12,14,16H2,1-2H3,(H,32,33)(H,28,29,34) AZDLISISCPPTLB-UHFFFAOYSA-N 265711 US9718790, I-1976 P2X purinoceptor 3 Homo sapiens 17.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265711 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265711&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945562 377004583 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505274 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(Cl)c2)n(Cc2ccc(C)cc2)c1=O 265712 US9718790, I-0593 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265712 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265712&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278251 377004584 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505275 CCOC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(OC)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H29ClN4O6/c1-5-35-22(31)12-13-29-24(32)28-23(30(25(29)33)15-17-6-8-18(26)9-7-17)27-19-10-11-20(36-16(2)3)21(14-19)34-4/h6-11,14,16H,5,12-13,15H2,1-4H3,(H,27,28,32) DOPAZBMVVTWVOE-UHFFFAOYSA-N 265713 US9718790, I-1248 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265713 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265713&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019938 377004585 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505276 NC(=O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccnc(O)c3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H19ClN6O5/c24-15-3-1-14(2-4-15)12-29-21(28-22(33)30(23(29)34)13-19(25)31)27-16-5-7-17(8-6-16)35-18-9-10-26-20(32)11-18/h1-11H,12-13H2,(H2,25,31)(H,26,32)(H,27,28,33) VGXBUGFVGCJCNT-UHFFFAOYSA-N 265714 US9718790, I-1977 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265714 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265714&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278620 377004586 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505277 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n(CCC2=NNNN2)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C22H24ClFN8O3/c1-13(2)35-18-8-7-16(11-17(18)24)25-20-26-21(33)31(10-9-19-27-29-30-28-19)22(34)32(20)12-14-3-5-15(23)6-4-14/h3-8,11,13,29-30H,9-10,12H2,1-2H3,(H,27,28)(H,25,26,33) DWOLNEDMWXPWGK-UHFFFAOYSA-N 265715 US9718790, I-0596 P2X purinoceptor 3 Homo sapiens 10.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265715 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265715&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278258 377004587 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505278 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(CC(C)C)c(OC)c2)n(Cc2ccc(C)cc2)c1=O 265716 US9718790, I-1249 P2X purinoceptor 3 Homo sapiens 21.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265716 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265716&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019948 377004588 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505279 CNC(=O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccnc(O)c3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H21ClN6O5/c1-26-21(33)14-31-23(34)29-22(30(24(31)35)13-15-2-4-16(25)5-3-15)28-17-6-8-18(9-7-17)36-19-10-11-27-20(32)12-19/h2-12H,13-14H2,1H3,(H,26,33)(H,27,32)(H,28,29,34) FIIDYGKSQFYWEZ-UHFFFAOYSA-N 265717 US9718790, I-1978 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265717 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265717&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945468 377004589 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505280 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc3n(C)c(C)cc3c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H28ClN5O4/c1-16-12-18-13-20(10-11-21(18)30(16)4)28-23-29-24(34)32(15-26(2,3)22(33)36-5)25(35)31(23)14-17-6-8-19(27)9-7-17/h6-13H,14-15H2,1-5H3,(H,28,29,34) HMFMTGYOEQYAPO-UHFFFAOYSA-N 265718 US9718790, I-0597 P2X purinoceptor 3 Homo sapiens 507 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265718 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265718&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118944996 377004590 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505281 CCCc1ccc(cc1C)\N=c1/[nH]c(=O)n(CCC(=O)OCC)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C25H29ClN4O4/c1-4-6-19-9-12-21(15-17(19)3)27-23-28-24(32)29(14-13-22(31)34-5-2)25(33)30(23)16-18-7-10-20(26)11-8-18/h7-12,15H,4-6,13-14,16H2,1-3H3,(H,27,28,32) WWZDJVQZKGGAKF-UHFFFAOYSA-N 265719 US9718790, I-1250 P2X purinoceptor 3 Homo sapiens 54.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265719 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265719&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019934 377004591 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505282 OCCNC(=O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccnc(O)c3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H23ClN6O6/c26-17-3-1-16(2-4-17)14-31-23(30-24(36)32(25(31)37)15-22(35)28-11-12-33)29-18-5-7-19(8-6-18)38-20-9-10-27-21(34)13-20/h1-10,13,33H,11-12,14-15H2,(H,27,34)(H,28,35)(H,29,30,36) DOIQMKMHHBGQGU-UHFFFAOYSA-N 265720 US9718790, I-1979 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265720 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265720&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130279137 377004592 C04080 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505283 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n(C\C(N)=N\O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C21H22ClFN6O4/c1-12(2)33-17-8-7-15(9-16(17)23)25-19-26-20(30)29(11-18(24)27-32)21(31)28(19)10-13-3-5-14(22)6-4-13/h3-9,12,32H,10-11H2,1-2H3,(H2,24,27)(H,25,26,30) KTJDRLLYUPKISB-UHFFFAOYSA-N 265721 US9718790, I-0599 P2X purinoceptor 3 Homo sapiens 38.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265721 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265721&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 88558717 377004593 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505284 CCOC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(CC(C)C)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H31ClN4O4/c1-5-35-23(32)12-13-30-25(33)29-24(28-22-11-8-20(14-17(2)3)18(4)15-22)31(26(30)34)16-19-6-9-21(27)10-7-19/h6-11,15,17H,5,12-14,16H2,1-4H3,(H,28,29,33) YUBGCYNKFPTSJC-UHFFFAOYSA-N 265722 US9718790, I-1251 P2X purinoceptor 3 Homo sapiens 17.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265722 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265722&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019850 377004594 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505285 Cc1ccc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(CC(=O)NCCO)c(=O)n2Cc2ccc(Cl)cc2)cn1 InChI=1S/C26H25ClN6O5/c1-17-2-9-22(14-29-17)38-21-10-7-20(8-11-21)30-24-31-25(36)33(16-23(35)28-12-13-34)26(37)32(24)15-18-3-5-19(27)6-4-18/h2-11,14,34H,12-13,15-16H2,1H3,(H,28,35)(H,30,31,36) WPIQPZVDTKHUNJ-UHFFFAOYSA-N 265723 US9718790, I-1980 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265723 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265723&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020174 377004595 C04080 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505286 CC(C)Oc1ccc(cc1F)\N=c1/[nH]\c(=N/O)n(CCC(=N)NO)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C22H25ClFN7O4/c1-13(2)35-18-8-7-16(11-17(18)24)26-20-27-21(29-34)30(10-9-19(25)28-33)22(32)31(20)12-14-3-5-15(23)6-4-14/h3-8,11,13,33-34H,9-10,12H2,1-2H3,(H2,25,28)(H,26,27,29) YGGBWVRFEZONRU-UHFFFAOYSA-N 265724 US9718790, I-0600 P2X purinoceptor 3 Homo sapiens 13.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265724 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265724&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 88558752 377004596 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505287 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(CC(C)C)c(F)c2)n(Cc2ccc(C)cc2)c1=O 265725 US9718790, I-1252 P2X purinoceptor 3 Homo sapiens 23.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265725 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265725&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019662 377004597 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505288 CC(C)Oc1ccc(cc1)\N=c1/[nH]c(=O)[nH]c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C19H19ClN4O3/c1-12(2)27-16-9-7-15(8-10-16)21-17-22-18(25)23-19(26)24(17)11-13-3-5-14(20)6-4-13/h3-10,12H,11H2,1-2H3,(H2,21,22,23,25,26) IREVTABVEZHHAG-UHFFFAOYSA-N 265726 US9718790, I-1981 P2X purinoceptor 3 Homo sapiens 354 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265726 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265726&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020517 377004598 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505289 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n(Cc2noc(=O)[nH]2)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C22H20ClFN6O5/c1-12(2)34-17-8-7-15(9-16(17)24)25-19-27-20(31)30(11-18-26-21(32)35-28-18)22(33)29(19)10-13-3-5-14(23)6-4-13/h3-9,12H,10-11H2,1-2H3,(H,25,27,31)(H,26,28,32) FEESDKNNEPNYTK-UHFFFAOYSA-N 265727 US9718790, I-0601 P2X purinoceptor 3 Homo sapiens 31.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265727 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265727&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 135121015 377004599 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505290 CCCc1ccc(cc1C)\N=c1/[nH]c(=O)n(CCC(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C23H25ClN4O4/c1-3-4-17-7-10-19(13-15(17)2)25-21-26-22(31)27(12-11-20(29)30)23(32)28(21)14-16-5-8-18(24)9-6-16/h5-10,13H,3-4,11-12,14H2,1-2H3,(H,29,30)(H,25,26,31) JRGGGJMGKLEZPM-UHFFFAOYSA-N 265728 US9718790, I-1253 P2X purinoceptor 3 Homo sapiens 281 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265728 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265728&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019853 377004600 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505291 CC1(C)OCC(Cn2c(=O)[nH]\c(=N/c3ccc4nc(sc4c3)C3CC3)n(Cc3ccc(Cl)cc3)c2=O)CO1 InChI=1S/C27H28ClN5O4S/c1-27(2)36-14-17(15-37-27)13-33-25(34)31-24(32(26(33)35)12-16-3-7-19(28)8-4-16)29-20-9-10-21-22(11-20)38-23(30-21)18-5-6-18/h3-4,7-11,17-18H,5-6,12-15H2,1-2H3,(H,29,31,34) WVRLHUZFVOTXSY-UHFFFAOYSA-N 265729 US9718790, I-1982 P2X purinoceptor 3 Homo sapiens 9.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265729 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265729&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020512 377004601 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505292 CCOc1ccc(cc1F)\N=c1/[nH]c(=O)n(C[C@H](C)C(=O)OC)c(=O)n1Cc1ccc(Cl)cc1 265730 US9718790, I-0602 P2X purinoceptor 3 Homo sapiens 20.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265730 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265730&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019516 377004602 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505293 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(CC(C)C)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O 265731 US9718790, I-1254 P2X purinoceptor 3 Homo sapiens 45.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265731 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265731&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019869 377004603 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506464 COC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(cn3)C#N)cc2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C27H24N6O5/c1-18-3-5-19(6-4-18)17-33-25(31-26(35)32(27(33)36)14-13-24(34)37-2)30-21-8-10-22(11-9-21)38-23-12-7-20(15-28)16-29-23/h3-12,16H,13-14,17H2,1-2H3,(H,30,31,35) GHKWQLYUTVMKGQ-UHFFFAOYSA-N 266895 US9718790, I-2636 P2X purinoceptor 3 Homo sapiens 2.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266895 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266895&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278256 377005766 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506465 CCn1c(=O)[nH]\c(=N/c2cccc(Oc3nccs3)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C21H18ClN5O3S/c1-2-26-19(28)25-18(27(21(26)29)13-14-6-8-15(22)9-7-14)24-16-4-3-5-17(12-16)30-20-23-10-11-31-20/h3-12H,2,13H2,1H3,(H,24,25,28) XHIBJCIYXAUMDD-UHFFFAOYSA-N 266896 US9718790, I-2637 P2X purinoceptor 3 Homo sapiens 177 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266896 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266896&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021216 377005767 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506466 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cncc(C)n3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H21ClN6O3/c1-3-29-22(31)28-21(30(23(29)32)14-16-4-6-17(24)7-5-16)27-18-8-10-19(11-9-18)33-20-13-25-12-15(2)26-20/h4-13H,3,14H2,1-2H3,(H,27,28,31) YTXFVKFOGRAXAM-UHFFFAOYSA-N 266897 US9718790, I-2638 P2X purinoceptor 3 Homo sapiens 15.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266897 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266897&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021213 377005768 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506467 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(CO)n3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H22ClN5O4/c1-2-29-23(32)28-22(30(24(29)33)14-16-6-8-17(25)9-7-16)27-18-10-12-20(13-11-18)34-21-5-3-4-19(15-31)26-21/h3-13,31H,2,14-15H2,1H3,(H,27,28,32) ISUNVAVKKQVPMF-UHFFFAOYSA-N 266898 US9718790, I-2639 P2X purinoceptor 3 Homo sapiens 26.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266898 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266898&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021215 377005769 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506468 Cc1ccc(Cn2c(=O)n(CCCO)c(=O)[nH]\c2=N/c2ccc(Oc3cccc(n3)C#N)cc2)cc1 InChI=1S/C26H24N6O4/c1-18-6-8-19(9-7-18)17-32-24(30-25(34)31(26(32)35)14-3-15-33)29-20-10-12-22(13-11-20)36-23-5-2-4-21(16-27)28-23/h2,4-13,33H,3,14-15,17H2,1H3,(H,29,30,34) RMROMRZXINTICU-UHFFFAOYSA-N 266899 US9718790, I-2640 P2X purinoceptor 3 Homo sapiens 2.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266899 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266899&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945730 377005770 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506469 COc1cccc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(CC(CO)CO)c(=O)n2Cc2ccc(Cl)cc2)n1 InChI=1S/C26H26ClN5O6/c1-37-22-3-2-4-23(29-22)38-21-11-9-20(10-12-21)28-24-30-25(35)32(14-18(15-33)16-34)26(36)31(24)13-17-5-7-19(27)8-6-17/h2-12,18,33-34H,13-16H2,1H3,(H,28,30,35) DKHCUXYTFSDJPT-UHFFFAOYSA-N 266900 US9718790, I-2641 P2X purinoceptor 3 Homo sapiens 12.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266900 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266900&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019903 377005771 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506470 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cnccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C22H19ClN6O3/c1-2-28-21(30)27-20(29(22(28)31)14-15-3-5-16(23)6-4-15)26-17-7-9-18(10-8-17)32-19-13-24-11-12-25-19/h3-13H,2,14H2,1H3,(H,26,27,30) PWNSZNHSGOJVSP-UHFFFAOYSA-N 266901 US9718790, I-2642 P2X purinoceptor 3 Homo sapiens 11.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266901 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266901&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019817 377005772 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506471 OC(=O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cnsn3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C20H15ClN6O5S/c21-13-3-1-12(2-4-13)10-26-18(24-19(30)27(20(26)31)11-17(28)29)23-14-5-7-15(8-6-14)32-16-9-22-33-25-16/h1-9H,10-11H2,(H,28,29)(H,23,24,30) NXHJRVHTOOCVSD-UHFFFAOYSA-N 266902 US9718790, I-2643 P2X purinoceptor 3 Homo sapiens 491 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266902 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266902&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278446 377005773 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506472 NC(=O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3nccs3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C21H17ClN6O4S/c22-14-3-1-13(2-4-14)11-27-18(26-19(30)28(21(27)31)12-17(23)29)25-15-5-7-16(8-6-15)32-20-24-9-10-33-20/h1-10H,11-12H2,(H2,23,29)(H,25,26,30) HJFDGKKMHHAZFR-UHFFFAOYSA-N 266903 US9718790, I-2644 P2X purinoceptor 3 Homo sapiens 17.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266903 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266903&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019910 377005774 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506473 CNC(=O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3nccs3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C22H19ClN6O4S/c1-24-18(30)13-29-20(31)27-19(28(22(29)32)12-14-2-4-15(23)5-3-14)26-16-6-8-17(9-7-16)33-21-25-10-11-34-21/h2-11H,12-13H2,1H3,(H,24,30)(H,26,27,31) NKAZJVMPLWACKQ-UHFFFAOYSA-N 266904 US9718790, I-2645 P2X purinoceptor 3 Homo sapiens 18.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266904 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266904&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130279142 377005775 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506474 OCCNC(=O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3nccs3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H21ClN6O5S/c24-16-3-1-15(2-4-16)13-29-20(28-21(33)30(23(29)34)14-19(32)25-9-11-31)27-17-5-7-18(8-6-17)35-22-26-10-12-36-22/h1-8,10,12,31H,9,11,13-14H2,(H,25,32)(H,27,28,33) DKIRTXBTUYGYOP-UHFFFAOYSA-N 266905 US9718790, I-2646 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266905 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266905&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945728 377005776 C04080 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506476 CNC(=O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ncc(C)s3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H21ClN6O4S/c1-14-11-26-22(35-14)34-18-9-7-17(8-10-18)27-20-28-21(32)30(13-19(31)25-2)23(33)29(20)12-15-3-5-16(24)6-4-15/h3-11H,12-13H2,1-2H3,(H,25,31)(H,27,28,32) OGKYFBMXIWJRAS-UHFFFAOYSA-N 266906 US9718790, I-2648 P2X purinoceptor 3 Homo sapiens 14.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266906 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266906&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020634 377005777 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506477 Cc1cnc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(CC(=O)NCCO)c(=O)n2Cc2ccc(Cl)cc2)s1 InChI=1S/C24H23ClN6O5S/c1-15-12-27-23(37-15)36-19-8-6-18(7-9-19)28-21-29-22(34)31(14-20(33)26-10-11-32)24(35)30(21)13-16-2-4-17(25)5-3-16/h2-9,12,32H,10-11,13-14H2,1H3,(H,26,33)(H,28,29,34) GZKHIRLEVDRCMG-UHFFFAOYSA-N 266907 US9718790, I-2649 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266907 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266907&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020623 377005778 C04080 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506478 COC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(F)n3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H21ClFN5O5/c1-36-22(33)13-14-31-24(34)30-23(32(25(31)35)15-16-5-7-17(26)8-6-16)28-18-9-11-19(12-10-18)37-21-4-2-3-20(27)29-21/h2-12H,13-15H2,1H3,(H,28,30,34) NTNCRWJCIRPSPX-UHFFFAOYSA-N 266908 US9718790, I-2650 P2X purinoceptor 3 Homo sapiens 3.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266908 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266908&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020664 377005779 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506479 COC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(Oc3nc(C)ns3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H21ClN6O5S/c1-14-25-22(36-28-14)35-18-9-7-17(8-10-18)26-20-27-21(32)29(12-11-19(31)34-2)23(33)30(20)13-15-3-5-16(24)6-4-15/h3-10H,11-13H2,1-2H3,(H,26,27,32) SVCKXPMOWJQLFJ-UHFFFAOYSA-N 266909 US9718790, I-2651 P2X purinoceptor 3 Homo sapiens 2.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266909 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266909&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020602 377005780 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506480 COC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ncns3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C22H19ClN6O5S/c1-33-18(30)10-11-28-20(31)27-19(29(22(28)32)12-14-2-4-15(23)5-3-14)26-16-6-8-17(9-7-16)34-21-24-13-25-35-21/h2-9,13H,10-12H2,1H3,(H,26,27,31) ZXDHFNYLRSEASC-UHFFFAOYSA-N 266910 US9718790, I-2652 P2X purinoceptor 3 Homo sapiens 3.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266910 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266910&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278447 377005781 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506481 OC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(F)n3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H19ClFN5O5/c25-16-6-4-15(5-7-16)14-31-22(29-23(34)30(24(31)35)13-12-21(32)33)27-17-8-10-18(11-9-17)36-20-3-1-2-19(26)28-20/h1-11H,12-14H2,(H,32,33)(H,27,29,34) VMNAMJVIIBBRMN-UHFFFAOYSA-N 266911 US9718790, I-2653 P2X purinoceptor 3 Homo sapiens 9.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266911 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266911&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278257 377005782 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506482 NC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(F)n3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H20ClFN6O4/c25-16-6-4-15(5-7-16)14-32-22(30-23(34)31(24(32)35)13-12-20(27)33)28-17-8-10-18(11-9-17)36-21-3-1-2-19(26)29-21/h1-11H,12-14H2,(H2,27,33)(H,28,30,34) BOPOTYRMYNKACW-UHFFFAOYSA-N 266912 US9718790, I-2654 P2X purinoceptor 3 Homo sapiens 9.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266912 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266912&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278448 377005783 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506483 CNC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(F)n3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H22ClFN6O4/c1-28-21(34)13-14-32-24(35)31-23(33(25(32)36)15-16-5-7-17(26)8-6-16)29-18-9-11-19(12-10-18)37-22-4-2-3-20(27)30-22/h2-12H,13-15H2,1H3,(H,28,34)(H,29,31,35) YRWIUWDNYIPDIF-UHFFFAOYSA-N 266913 US9718790, I-2655 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266913 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266913&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278669 377005784 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506484 CNC(=O)Nc1cc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(C)c(=O)n2Cc2ccc(Cl)cc2)ccn1 InChI=1S/C24H22ClN7O4/c1-26-22(33)29-20-13-19(11-12-27-20)36-18-9-7-17(8-10-18)28-21-30-23(34)31(2)24(35)32(21)14-15-3-5-16(25)6-4-15/h3-13H,14H2,1-2H3,(H,28,30,34)(H2,26,27,29,33) ROBPEGJSLSJAIS-UHFFFAOYSA-N 266914 US9718790, I-2656 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266914 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266914&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020351 377005785 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506485 CCOC(=O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ncccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H21ClN6O5/c1-2-35-20(32)15-31-23(33)29-21(30(24(31)34)14-16-4-6-17(25)7-5-16)28-18-8-10-19(11-9-18)36-22-26-12-3-13-27-22/h3-13H,2,14-15H2,1H3,(H,28,29,33) ZQUXOVRVYMIZKC-UHFFFAOYSA-N 266915 US9718790, I-2657 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266915 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266915&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020258 377005786 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506486 CCOC(=O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cccnn3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H21ClN6O5/c1-2-35-21(32)15-31-23(33)28-22(30(24(31)34)14-16-5-7-17(25)8-6-16)27-18-9-11-19(12-10-18)36-20-4-3-13-26-29-20/h3-13H,2,14-15H2,1H3,(H,27,28,33) DKLAXHNNVODHTR-UHFFFAOYSA-N 266916 US9718790, I-2658 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266916 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266916&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945725 377005787 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506487 OC(=O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ncns3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C20H15ClN6O5S/c21-13-3-1-12(2-4-13)9-26-17(25-18(30)27(20(26)31)10-16(28)29)24-14-5-7-15(8-6-14)32-19-22-11-23-33-19/h1-8,11H,9-10H2,(H,28,29)(H,24,25,30) IQJAXZCYXWLUKM-UHFFFAOYSA-N 266917 US9718790, I-2659 P2X purinoceptor 3 Homo sapiens 277 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266917 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266917&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020296 377005788 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506488 COC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cc(ccn3)C#N)cc2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C27H24N6O5/c1-18-3-5-19(6-4-18)17-33-25(31-26(35)32(27(33)36)14-12-24(34)37-2)30-21-7-9-22(10-8-21)38-23-15-20(16-28)11-13-29-23/h3-11,13,15H,12,14,17H2,1-2H3,(H,30,31,35) LKQGXLNMMQZCFL-UHFFFAOYSA-N 266918 US9718790, I-2660 P2X purinoceptor 3 Homo sapiens 3.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266918 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266918&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278425 377005789 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506489 Cc1ccc(Cn2c(=O)n(CCC(O)=O)c(=O)[nH]\c2=N/c2ccc(Oc3cc(ccn3)C#N)cc2)cc1 InChI=1S/C26H22N6O5/c1-17-2-4-18(5-3-17)16-32-24(30-25(35)31(26(32)36)13-11-23(33)34)29-20-6-8-21(9-7-20)37-22-14-19(15-27)10-12-28-22/h2-10,12,14H,11,13,16H2,1H3,(H,33,34)(H,29,30,35) VIVWZNGYJUVFDH-UHFFFAOYSA-N 266919 US9718790, I-2661 P2X purinoceptor 3 Homo sapiens 15.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266919 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266919&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020591 377005790 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506490 OC(=O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cccnn3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C22H17ClN6O5/c23-15-5-3-14(4-6-15)12-28-20(26-21(32)29(22(28)33)13-19(30)31)25-16-7-9-17(10-8-16)34-18-2-1-11-24-27-18/h1-11H,12-13H2,(H,30,31)(H,25,26,32) JETYUAVFWXOLPH-UHFFFAOYSA-N 266920 US9718790, I-2663 P2X purinoceptor 3 Homo sapiens 330 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266920 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266920&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020661 377005791 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506491 CCOC(=O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccnnc3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H21ClN6O5/c1-2-35-21(32)15-31-23(33)29-22(30(24(31)34)14-16-3-5-17(25)6-4-16)28-18-7-9-19(10-8-18)36-20-11-12-26-27-13-20/h3-13H,2,14-15H2,1H3,(H,28,29,33) CBQZOUMTGADUNQ-UHFFFAOYSA-N 266921 US9718790, I-2664 P2X purinoceptor 3 Homo sapiens 3.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266921 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266921&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945495 377005792 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506492 OC(=O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccnnc3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C22H17ClN6O5/c23-15-3-1-14(2-4-15)12-28-20(27-21(32)29(22(28)33)13-19(30)31)26-16-5-7-17(8-6-16)34-18-9-10-24-25-11-18/h1-11H,12-13H2,(H,30,31)(H,26,27,32) GQOYJGVICLCURB-UHFFFAOYSA-N 266922 US9718790, I-2665 P2X purinoceptor 3 Homo sapiens 85.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266922 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266922&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945515 377005793 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506493 COC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(n3)C#N)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H21ClN6O5/c1-37-23(34)13-14-32-25(35)31-24(33(26(32)36)16-17-5-7-18(27)8-6-17)30-19-9-11-21(12-10-19)38-22-4-2-3-20(15-28)29-22/h2-12H,13-14,16H2,1H3,(H,30,31,35) ZDHZAXPPIBGBGD-UHFFFAOYSA-N 266923 US9718790, I-2666 P2X purinoceptor 3 Homo sapiens 2.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266923 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266923&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945607 377005794 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506494 OC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(n3)C#N)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H19ClN6O5/c26-17-6-4-16(5-7-17)15-32-23(30-24(35)31(25(32)36)13-12-22(33)34)29-18-8-10-20(11-9-18)37-21-3-1-2-19(14-27)28-21/h1-11H,12-13,15H2,(H,33,34)(H,29,30,35) LVFXZTMCDMAENT-UHFFFAOYSA-N 266924 US9718790, I-2667 P2X purinoceptor 3 Homo sapiens 10.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266924 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266924&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278641 377005795 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506495 Cc1ccc(Cn2c(=O)n(CCC(O)=O)c(=O)[nH]\c2=N/c2ccc(Oc3cc(ccn3)C(O)=O)cc2)cc1 InChI=1S/C26H23N5O7/c1-16-2-4-17(5-3-16)15-31-24(29-25(36)30(26(31)37)13-11-22(32)33)28-19-6-8-20(9-7-19)38-21-14-18(23(34)35)10-12-27-21/h2-10,12,14H,11,13,15H2,1H3,(H,32,33)(H,34,35)(H,28,29,36) UFZXBXWMLZTITA-UHFFFAOYSA-N 266925 US9718790, I-2671 P2X purinoceptor 3 Homo sapiens 36.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266925 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266925&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021223 377005796 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506496 CC(C)(O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccon3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H22ClN5O5/c1-23(2,32)14-29-21(30)26-20(28(22(29)31)13-15-3-5-16(24)6-4-15)25-17-7-9-18(10-8-17)34-19-11-12-33-27-19/h3-12,32H,13-14H2,1-2H3,(H,25,26,30) SMQPFSJHPDPQPU-UHFFFAOYSA-N 266926 US9718790, I-2672 P2X purinoceptor 3 Homo sapiens 11.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266926 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266926&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021227 377005797 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506497 CNC(=O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ncns3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C21H18ClN7O4S/c1-23-17(30)11-29-19(31)27-18(28(21(29)32)10-13-2-4-14(22)5-3-13)26-15-6-8-16(9-7-15)33-20-24-12-25-34-20/h2-9,12H,10-11H2,1H3,(H,23,30)(H,26,27,31) JIFIONANCZXBDY-UHFFFAOYSA-N 266927 US9718790, I-2673 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266927 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266927&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021225 377005798 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506498 OCCNC(=O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ncns3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C22H20ClN7O5S/c23-15-3-1-14(2-4-15)11-29-19(28-20(33)30(22(29)34)12-18(32)24-9-10-31)27-16-5-7-17(8-6-16)35-21-25-13-26-36-21/h1-8,13,31H,9-12H2,(H,24,32)(H,27,28,33) JKNVGNDKAAVYQP-UHFFFAOYSA-N 266928 US9718790, I-2674 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266928 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266928&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021224 377005799 C04080 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506499 NC(=O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cnsn3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C20H16ClN7O4S/c21-13-3-1-12(2-4-13)10-27-18(25-19(30)28(20(27)31)11-16(22)29)24-14-5-7-15(8-6-14)32-17-9-23-33-26-17/h1-9H,10-11H2,(H2,22,29)(H,24,25,30) GQTWXGMPVNPUKY-UHFFFAOYSA-N 266929 US9718790, I-2675 P2X purinoceptor 3 Homo sapiens 13.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266929 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266929&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019912 377005800 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506500 CNC(=O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cnsn3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C21H18ClN7O4S/c1-23-17(30)12-29-20(31)26-19(28(21(29)32)11-13-2-4-14(22)5-3-13)25-15-6-8-16(9-7-15)33-18-10-24-34-27-18/h2-10H,11-12H2,1H3,(H,23,30)(H,25,26,31) IEBAKJLSPTXKOZ-UHFFFAOYSA-N 266930 US9718790, I-2676 P2X purinoceptor 3 Homo sapiens 13.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266930 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266930&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130279171 377005801 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506501 OCCNC(=O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cnsn3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C22H20ClN7O5S/c23-15-3-1-14(2-4-15)12-29-20(27-21(33)30(22(29)34)13-18(32)24-9-10-31)26-16-5-7-17(8-6-16)35-19-11-25-36-28-19/h1-8,11,31H,9-10,12-13H2,(H,24,32)(H,26,27,33) YWTYUIDETVSYCZ-UHFFFAOYSA-N 266931 US9718790, I-2677 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266931 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266931&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130279148 377005802 C04080 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506502 Cc1nsc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(CC(=O)NCCO)c(=O)n2Cc2ccc(Cl)cc2)n1 InChI=1S/C23H22ClN7O5S/c1-14-26-22(37-29-14)36-18-8-6-17(7-9-18)27-20-28-21(34)31(13-19(33)25-10-11-32)23(35)30(20)12-15-2-4-16(24)5-3-15/h2-9,32H,10-13H2,1H3,(H,25,33)(H,27,28,34) XENKFLLHMXTJCH-UHFFFAOYSA-N 266932 US9718790, I-2678 P2X purinoceptor 3 Homo sapiens 3.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266932 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266932&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019888 377005803 C04080 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506503 OCCNC(=O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(F)n3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H22ClFN6O5/c26-17-6-4-16(5-7-17)14-32-23(31-24(36)33(25(32)37)15-21(35)28-12-13-34)29-18-8-10-19(11-9-18)38-22-3-1-2-20(27)30-22/h1-11,34H,12-15H2,(H,28,35)(H,29,31,36) MWFIRGPESLHIDQ-UHFFFAOYSA-N 266933 US9718790, I-2679 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266933 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266933&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021087 377005804 C04080 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506504 OCCNC(=O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccon3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H21ClN6O6/c24-16-3-1-15(2-4-16)13-29-21(27-22(33)30(23(29)34)14-19(32)25-10-11-31)26-17-5-7-18(8-6-17)36-20-9-12-35-28-20/h1-9,12,31H,10-11,13-14H2,(H,25,32)(H,26,27,33) ZCTIMLPRQYZIAE-UHFFFAOYSA-N 266934 US9718790, I-2680 P2X purinoceptor 3 Homo sapiens 12.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266934 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266934&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021079 377005805 C04080 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506505 FC(F)(F)CNC(=O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccon3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H18ClF3N6O5/c24-15-3-1-14(2-4-15)11-32-20(29-16-5-7-17(8-6-16)38-19-9-10-37-31-19)30-21(35)33(22(32)36)12-18(34)28-13-23(25,26)27/h1-10H,11-13H2,(H,28,34)(H,29,30,35) IWNJAJSNJVMGHU-UHFFFAOYSA-N 266935 US9718790, I-2681 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266935 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266935&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021097 377005806 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506506 COC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(n3)C(N)=O)cc2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C27H26N6O6/c1-17-6-8-18(9-7-17)16-33-25(31-26(36)32(27(33)37)15-14-23(34)38-2)29-19-10-12-20(13-11-19)39-22-5-3-4-21(30-22)24(28)35/h3-13H,14-16H2,1-2H3,(H2,28,35)(H,29,31,36) PRKOXLJKFCFNFA-UHFFFAOYSA-N 266936 US9718790, I-2682 P2X purinoceptor 3 Homo sapiens 2.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266936 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266936&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021067 377005807 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506507 Cc1ccc(Cn2c(=O)n(CCC(O)=O)c(=O)[nH]\c2=N/c2ccc(Oc3cccc(n3)C(N)=O)cc2)cc1 InChI=1S/C26H24N6O6/c1-16-5-7-17(8-6-16)15-32-24(30-25(36)31(26(32)37)14-13-22(33)34)28-18-9-11-19(12-10-18)38-21-4-2-3-20(29-21)23(27)35/h2-12H,13-15H2,1H3,(H2,27,35)(H,33,34)(H,28,30,36) MPHGRPCVNBVYJL-UHFFFAOYSA-N 266937 US9718790, I-2683 P2X purinoceptor 3 Homo sapiens 12.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266937 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266937&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021125 377005808 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506508 COC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(n3)C(N)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H23ClN6O6/c1-38-22(34)13-14-32-25(36)31-24(33(26(32)37)15-16-5-7-17(27)8-6-16)29-18-9-11-19(12-10-18)39-21-4-2-3-20(30-21)23(28)35/h2-12H,13-15H2,1H3,(H2,28,35)(H,29,31,36) VLIDDWCOGMOZLQ-UHFFFAOYSA-N 266938 US9718790, I-2684 P2X purinoceptor 3 Homo sapiens 2.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266938 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266938&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021109 377005809 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506509 OCC(CO)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(O)n3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H24ClN5O6/c26-18-6-4-16(5-7-18)12-30-23(29-24(35)31(25(30)36)13-17(14-32)15-33)27-19-8-10-20(11-9-19)37-22-3-1-2-21(34)28-22/h1-11,17,32-33H,12-15H2,(H,28,34)(H,27,29,35) HDYVHCBUUQKEGK-UHFFFAOYSA-N 266939 US9718790, I-2685 P2X purinoceptor 3 Homo sapiens 12.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266939 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266939&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021175 377005810 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506510 NC(=O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ncccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C22H18ClN7O4/c23-15-4-2-14(3-5-15)12-29-19(28-21(32)30(22(29)33)13-18(24)31)27-16-6-8-17(9-7-16)34-20-25-10-1-11-26-20/h1-11H,12-13H2,(H2,24,31)(H,27,28,32) XHBBGJZQHLNWNN-UHFFFAOYSA-N 266940 US9718790, I-2686 P2X purinoceptor 3 Homo sapiens 36.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266940 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266940&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021139 377005811 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506511 CNC(=O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ncccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H20ClN7O4/c1-25-19(32)14-31-22(33)29-20(30(23(31)34)13-15-3-5-16(24)6-4-15)28-17-7-9-18(10-8-17)35-21-26-11-2-12-27-21/h2-12H,13-14H2,1H3,(H,25,32)(H,28,29,33) MVPYLPQRXZSANX-UHFFFAOYSA-N 266941 US9718790, I-2687 P2X purinoceptor 3 Homo sapiens 35.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266941 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266941&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020599 377005812 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506512 OCCNC(=O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ncccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H22ClN7O5/c25-17-4-2-16(3-5-17)14-31-21(30-23(35)32(24(31)36)15-20(34)26-12-13-33)29-18-6-8-19(9-7-18)37-22-27-10-1-11-28-22/h1-11,33H,12-15H2,(H,26,34)(H,29,30,35) NAMRTISNIRRKCH-UHFFFAOYSA-N 266942 US9718790, I-2688 P2X purinoceptor 3 Homo sapiens 18.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266942 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266942&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020569 377005813 C04080 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506513 NC(=O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cccnn3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C22H18ClN7O4/c23-15-5-3-14(4-6-15)12-29-20(27-21(32)30(22(29)33)13-18(24)31)26-16-7-9-17(10-8-16)34-19-2-1-11-25-28-19/h1-11H,12-13H2,(H2,24,31)(H,26,27,32) KUGWBEVWXDMKED-UHFFFAOYSA-N 266943 US9718790, I-2689 P2X purinoceptor 3 Homo sapiens 20.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266943 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266943&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020657 377005814 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506514 CNC(=O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cccnn3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H20ClN7O4/c1-25-19(32)14-31-22(33)28-21(30(23(31)34)13-15-4-6-16(24)7-5-15)27-17-8-10-18(11-9-17)35-20-3-2-12-26-29-20/h2-12H,13-14H2,1H3,(H,25,32)(H,27,28,33) DMNGUPKGJOLWKA-UHFFFAOYSA-N 266944 US9718790, I-2690 P2X purinoceptor 3 Homo sapiens 18.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266944 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266944&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020653 377005815 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506515 OCCNC(=O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cccnn3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H22ClN7O5/c25-17-5-3-16(4-6-17)14-31-22(29-23(35)32(24(31)36)15-20(34)26-12-13-33)28-18-7-9-19(10-8-18)37-21-2-1-11-27-30-21/h1-11,33H,12-15H2,(H,26,34)(H,28,29,35) NVEXMDCCSGWNQU-UHFFFAOYSA-N 266945 US9718790, I-2691 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266945 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266945&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021107 377005816 C04080 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506516 OCC(CO)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cccnn3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H23ClN6O5/c25-18-5-3-16(4-6-18)12-30-22(28-23(34)31(24(30)35)13-17(14-32)15-33)27-19-7-9-20(10-8-19)36-21-2-1-11-26-29-21/h1-11,17,32-33H,12-15H2,(H,27,28,34) ADWDKSGQIYOENG-UHFFFAOYSA-N 266946 US9718790, I-2692 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266946 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266946&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021134 377005817 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506517 NC(=O)c1cccc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(CCC(O)=O)c(=O)n2Cc2ccc(Cl)cc2)n1 InChI=1S/C25H21ClN6O6/c26-16-6-4-15(5-7-16)14-32-23(30-24(36)31(25(32)37)13-12-21(33)34)28-17-8-10-18(11-9-17)38-20-3-1-2-19(29-20)22(27)35/h1-11H,12-14H2,(H2,27,35)(H,33,34)(H,28,30,36) LQLNKRDFHDWKGQ-UHFFFAOYSA-N 266947 US9718790, I-2693 P2X purinoceptor 3 Homo sapiens 12.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266947 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266947&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021122 377005818 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506518 NC(=O)NC(=O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccon3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C22H18ClN7O6/c23-14-3-1-13(2-4-14)11-29-20(27-21(33)30(22(29)34)12-17(31)26-19(24)32)25-15-5-7-16(8-6-15)36-18-9-10-35-28-18/h1-10H,11-12H2,(H,25,27,33)(H3,24,26,31,32) DTJIFAKOWSUVPI-UHFFFAOYSA-N 266948 US9718790, I-2694 P2X purinoceptor 3 Homo sapiens 3.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266948 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266948&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021106 377005819 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506519 NC(=O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccnnc3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C22H18ClN7O4/c23-15-3-1-14(2-4-15)12-29-20(28-21(32)30(22(29)33)13-19(24)31)27-16-5-7-17(8-6-16)34-18-9-10-25-26-11-18/h1-11H,12-13H2,(H2,24,31)(H,27,28,32) AQAWNTXMCGNERK-UHFFFAOYSA-N 266949 US9718790, I-2695 P2X purinoceptor 3 Homo sapiens 10.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266949 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266949&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020632 377005820 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506520 CNC(=O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccnnc3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H20ClN7O4/c1-25-20(32)14-31-22(33)29-21(30(23(31)34)13-15-2-4-16(24)5-3-15)28-17-6-8-18(9-7-17)35-19-10-11-26-27-12-19/h2-12H,13-14H2,1H3,(H,25,32)(H,28,29,33) IHYDFUFSCIOXPH-UHFFFAOYSA-N 266950 US9718790, I-2696 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266950 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266950&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020621 377005821 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506521 Cc1nsc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(CCC(O)=O)c(=O)n2Cc2ccc(Cl)cc2)n1 InChI=1S/C22H19ClN6O5S/c1-13-24-21(35-27-13)34-17-8-6-16(7-9-17)25-19-26-20(32)28(11-10-18(30)31)22(33)29(19)12-14-2-4-15(23)5-3-14/h2-9H,10-12H2,1H3,(H,30,31)(H,25,26,32) WJVKQAZCLUVILL-UHFFFAOYSA-N 266951 US9718790, I-2697 P2X purinoceptor 3 Homo sapiens 19.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266951 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266951&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020663 377005822 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506522 OC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ncns3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C21H17ClN6O5S/c22-14-3-1-13(2-4-14)11-28-18(26-19(31)27(21(28)32)10-9-17(29)30)25-15-5-7-16(8-6-15)33-20-23-12-24-34-20/h1-8,12H,9-11H2,(H,29,30)(H,25,26,31) LTDXKYOHZOOTRQ-UHFFFAOYSA-N 266952 US9718790, I-2698 P2X purinoceptor 3 Homo sapiens 25.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266952 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266952&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020597 377005823 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506523 CCn1c(=O)nc(Nc2ccc(Oc3ccc(nn3)C(O)=O)cc2)n(Cc2ccc(F)cc2)c1=O InChI=1S/C23H19FN6O5/c1-2-29-22(33)26-21(30(23(29)34)13-14-3-5-15(24)6-4-14)25-16-7-9-17(10-8-16)35-19-12-11-18(20(31)32)27-28-19/h3-12H,2,13H2,1H3,(H,31,32)(H,25,26,33) WEQRRYSIVKPJAZ-UHFFFAOYSA-N 266953 US9718790, I-2699 P2X purinoceptor 3 Homo sapiens 134 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266953 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266953&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 135121024 377005824 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506524 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(cn3)C(=O)OC)cc2)n(C[C@H]2CC[C@H](C)CC2)c1=O 266954 US9718790, I-2700 P2X purinoceptor 3 Homo sapiens 353 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266954 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266954&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019887 377005825 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506525 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(nn3)C(=O)OC)cc2)n(C[C@H]2CC[C@H](C)CC2)c1=O 266955 US9718790, I-2701 P2X purinoceptor 3 Homo sapiens 1.000 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266955 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266955&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945747 377005826 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506526 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cc(ccn3)C#N)cc2)n(C[C@H]2CC[C@H](C)CC2)c1=O 266956 US9718790, I-2702 P2X purinoceptor 3 Homo sapiens 3.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266956 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266956&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278381 377005827 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506527 OCC(CO)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccnc(Cl)c3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H23Cl2N5O5/c26-18-3-1-16(2-4-18)12-31-23(30-24(35)32(25(31)36)13-17(14-33)15-34)29-19-5-7-20(8-6-19)37-21-9-10-28-22(27)11-21/h1-11,17,33-34H,12-15H2,(H,29,30,35) HUPURNMFZLMPCI-UHFFFAOYSA-N 266957 US9718790, I-2704 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266957 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266957&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 88558819 377005828 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506528 OCC(CO)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccnc(F)c3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H23ClFN5O5/c26-18-3-1-16(2-4-18)12-31-23(30-24(35)32(25(31)36)13-17(14-33)15-34)29-19-5-7-20(8-6-19)37-21-9-10-28-22(27)11-21/h1-11,17,33-34H,12-15H2,(H,29,30,35) GQBUWEFJNJYPLT-UHFFFAOYSA-N 266958 US9718790, I-2705 P2X purinoceptor 3 Homo sapiens 3.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266958 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266958&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020654 377005829 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506529 OCC(CO)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ncccc3F)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H23ClFN5O5/c26-18-5-3-16(4-6-18)12-31-23(30-24(35)32(25(31)36)13-17(14-33)15-34)29-19-7-9-20(10-8-19)37-22-21(27)2-1-11-28-22/h1-11,17,33-34H,12-15H2,(H,29,30,35) BMGXHRXVLDHVSJ-UHFFFAOYSA-N 266959 US9718790, I-2706 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266959 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266959&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020581 377005830 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506530 Cc1nsc(Oc2ccc(cc2F)\N=c2/[nH]c(=O)n(C[C@H](O)CO)c(=O)n2Cc2ccc(F)cc2)n1 266960 US9718790, I-2707 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266960 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266960&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278274 377005831 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506531 Cc1nsc(Oc2ccc(cc2F)\N=c2/[nH]c(=O)n(C[C@H](O)CO)c(=O)n2Cc2ccc(Cl)cc2)n1 266961 US9718790, I-2708 P2X purinoceptor 3 Homo sapiens 2.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266961 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266961&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278450 377005832 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506532 Cc1cncc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(CC(CO)CO)c(=O)n2Cc2ccc(Cl)cc2)n1 InChI=1S/C25H25ClN6O5/c1-16-10-27-11-22(28-16)37-21-8-6-20(7-9-21)29-23-30-24(35)32(13-18(14-33)15-34)25(36)31(23)12-17-2-4-19(26)5-3-17/h2-11,18,33-34H,12-15H2,1H3,(H,29,30,35) VSWUBFODBOSLOR-UHFFFAOYSA-N 266962 US9718790, I-2709 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266962 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266962&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278426 377005833 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506533 OCC(CO)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cnccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H23ClN6O5/c25-18-3-1-16(2-4-18)12-30-22(29-23(34)31(24(30)35)13-17(14-32)15-33)28-19-5-7-20(8-6-19)36-21-11-26-9-10-27-21/h1-11,17,32-33H,12-15H2,(H,28,29,34) CHDYQXDXWDFZAM-UHFFFAOYSA-N 266963 US9718790, I-2710 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266963 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266963&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945740 377005834 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504798 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(OC3CCOCC3)cc2)n(Cc2ccc(C)cc2)c1=O 265246 US9718790, I-1073 P2X purinoceptor 3 Homo sapiens 92.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265246 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265246&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278177 377004121 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504799 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc3NC(=O)COc3c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 265247 US9718790, I-1786 P2X purinoceptor 3 Homo sapiens 621 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265247 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265247&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945361 377004122 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504800 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n(CC(=O)N[C@H](C)C(O)=O)c(=O)n1Cc1ccc(C)cc1 183246 US9150546, I-417::US9688643, I-417::US9718790, I-0416 P2X purinoceptor 3 Homo sapiens 35.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183246 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183246&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 70645187 313634646 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504801 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(OC3CCOCC3)cc2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 265249 US9718790, I-1074 P2X purinoceptor 3 Homo sapiens 86.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265249 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265249&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278307 377004124 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504802 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccnc(c3)C(O)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H20ClN5O5/c1-2-29-23(33)28-22(30(24(29)34)14-15-3-5-16(25)6-4-15)27-17-7-9-18(10-8-17)35-19-11-12-26-20(13-19)21(31)32/h3-13H,2,14H2,1H3,(H,31,32)(H,27,28,33) HQDKXIYLVPUFME-UHFFFAOYSA-N 265250 US9718790, I-1788 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265250 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265250&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278392 377004125 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504803 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n(CC(=O)N[C@@H](C)C(O)=O)c(=O)n1Cc1ccc(C)cc1 183247 US9150546, I-418::US9688643, I-418::US9718790, I-0417 P2X purinoceptor 3 Homo sapiens 200 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183247 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183247&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 70645188 313634647 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504804 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Br)cc2)n(Cc2ccc(C)cc2)c1=O 265252 US9718790, I-1076 P2X purinoceptor 3 Homo sapiens 177 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265252 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265252&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021022 377004127 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504805 OCCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(O)nc3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H20ClN5O5/c24-16-3-1-15(2-4-16)14-29-21(27-22(32)28(11-12-30)23(29)33)26-17-5-7-18(8-6-17)34-19-9-10-20(31)25-13-19/h1-10,13,30H,11-12,14H2,(H,25,31)(H,26,27,32) FZBKFODZKQAEKX-UHFFFAOYSA-N 265253 US9718790, I-1789 P2X purinoceptor 3 Homo sapiens 30.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265253 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265253&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945563 377004128 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504806 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n(CC(=O)NC2(CC2)C(O)=O)c(=O)n1Cc1ccc(C)cc1 InChI=1S/C26H28FN5O6/c1-15(2)38-20-9-8-18(12-19(20)27)28-23-29-24(36)32(14-21(33)30-26(10-11-26)22(34)35)25(37)31(23)13-17-6-4-16(3)5-7-17/h4-9,12,15H,10-11,13-14H2,1-3H3,(H,30,33)(H,34,35)(H,28,29,36) FYJMAFNQGXRCEC-UHFFFAOYSA-N 183248 US9150546, I-419::US9688643, I-419::US9718790, I-0418 P2X purinoceptor 3 Homo sapiens 71.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183248 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183248&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020393 313634648 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504807 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2cccc(Br)c2)n(Cc2ccc(C)cc2)c1=O 265255 US9718790, I-1077 P2X purinoceptor 3 Homo sapiens 64.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265255 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265255&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020990 377004130 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504808 CCCc1nc2ccc(cc2s1)\N=c1/[nH]c(=O)n([C@@H](C)[C@@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 265256 US9718790, I-1792 P2X purinoceptor 3 Homo sapiens 20.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265256 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265256&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945299 377004131 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504809 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n(CCC(C)(C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C25H28ClFN4O5/c1-15(2)36-20-10-9-18(13-19(20)27)28-22-29-23(34)30(12-11-25(3,4)21(32)33)24(35)31(22)14-16-5-7-17(26)8-6-16/h5-10,13,15H,11-12,14H2,1-4H3,(H,32,33)(H,28,29,34) GXZHRQJRSCDCAT-UHFFFAOYSA-N 183249 US9150546, I-420::US9688643, I-420::US9718790, I-0419 P2X purinoceptor 3 Homo sapiens 53.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183249 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183249&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578915 313634649 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504810 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(cc2)C2=CCCCC2)n(Cc2ccc(C)cc2)c1=O 265258 US9718790, I-1078 P2X purinoceptor 3 Homo sapiens 218 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265258 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265258&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021025 377004133 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504811 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc3nc(NC(C)=O)sc3c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 265259 US9718790, I-1793 P2X purinoceptor 3 Homo sapiens 984 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265259 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265259&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945235 377004134 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504812 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(CCC(C)(C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C25H28Cl2N4O5/c1-15(2)36-20-10-9-18(13-19(20)27)28-22-29-23(34)30(12-11-25(3,4)21(32)33)24(35)31(22)14-16-5-7-17(26)8-6-16/h5-10,13,15H,11-12,14H2,1-4H3,(H,32,33)(H,28,29,34) PIKUFVDOUKAUFW-UHFFFAOYSA-N 183250 US9150546, I-421::US9688643, I-421::US9718790, I-0420 P2X purinoceptor 3 Homo sapiens 19.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183250 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183250&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578771 313634650 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504813 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)cc2)n(Cc2ccc(I)cc2)c1=O 265261 US9718790, I-1080 P2X purinoceptor 3 Homo sapiens 66.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265261 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265261&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021034 377004136 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504814 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc3nc([nH]c3c2)C(F)(F)F)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O InChI=1S/C23H18ClF3N6O4/c1-11(18(34)35)12(2)33-21(36)31-20(32(22(33)37)10-13-3-5-14(24)6-4-13)28-15-7-8-16-17(9-15)30-19(29-16)23(25,26)27/h3-9,11-12H,10H2,1-2H3,(H,34,35)/b28-15+/t11-,12+/m1/s1 HVRZKFQXTVJCFK-PHRVEKLISA-N 265262 US9718790, I-1794 P2X purinoceptor 3 Homo sapiens 380 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265262 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265262&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278394 377004137 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504815 CCOC(=O)C1(Cn2c(=O)[nH]\c(=N/c3ccc(OC(C)C)c(F)c3)n(Cc3ccc(Cl)cc3)c2=O)CC1 InChI=1S/C26H28ClFN4O5/c1-4-36-22(33)26(11-12-26)15-32-24(34)30-23(29-19-9-10-21(20(28)13-19)37-16(2)3)31(25(32)35)14-17-5-7-18(27)8-6-17/h5-10,13,16H,4,11-12,14-15H2,1-3H3,(H,29,30,34) RNAJCWWHBFPQGC-UHFFFAOYSA-N 183251 US9150546, I-422::US9688643, I-422::US9718790, I-0421 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183251 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183251&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578741 313634651 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504816 COC(=O)[C@H](C)[C@H](C)n1c(=O)[nH]\c(=N/c2ccc(OC(C)C)cc2)n(Cc2ccc(C)cc2)c1=O 265264 US9718790, I-1081 P2X purinoceptor 3 Homo sapiens 30.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265264 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265264&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021052 377004139 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504817 COC(=O)[C@H](C)[C@H](C)n1c(=O)[nH]\c(=N/c2ccc3nc(C)[nH]c3c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H23ClN6O4/c1-13(21(32)35-4)14(2)31-23(33)29-22(28-18-9-10-19-20(11-18)27-15(3)26-19)30(24(31)34)12-16-5-7-17(25)8-6-16/h5-11,13-14H,12H2,1-4H3/b28-18+/t13-,14+/m1/s1 RLUZQVJBESEQBD-FTORBMHHSA-N 265265 US9718790, I-1795 P2X purinoceptor 3 Homo sapiens 795 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265265 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265265&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945286 377004140 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504818 CCOC(=O)C1(Cn2c(=O)[nH]\c(=N/c3ccc(OC(C)C)c(Cl)c3)n(Cc3ccc(Cl)cc3)c2=O)CC1 InChI=1S/C26H28Cl2N4O5/c1-4-36-22(33)26(11-12-26)15-32-24(34)30-23(29-19-9-10-21(20(28)13-19)37-16(2)3)31(25(32)35)14-17-5-7-18(27)8-6-17/h5-10,13,16H,4,11-12,14-15H2,1-3H3,(H,29,30,34) OMQZQMMOKOGJNF-UHFFFAOYSA-N 183252 US9150546, I-423::US9718790, I-0422 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183252 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183252&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578896 313634652 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504819 CC(C)Oc1ccc(cc1)\N=c1/[nH]c(=O)n([C@@H](C)[C@@H](C)C(O)=O)c(=O)n1Cc1ccc(C)cc1 265267 US9718790, I-1082 P2X purinoceptor 3 Homo sapiens 63.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265267 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265267&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278550 377004142 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504820 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc3CCCCc3c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 265268 US9718790, I-1796 P2X purinoceptor 3 Homo sapiens 587 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265268 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265268&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020279 377004143 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504821 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n(CC2(CC2)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C24H24ClFN4O5/c1-14(2)35-19-8-7-17(11-18(19)26)27-21-28-22(33)30(13-24(9-10-24)20(31)32)23(34)29(21)12-15-3-5-16(25)6-4-15/h3-8,11,14H,9-10,12-13H2,1-2H3,(H,31,32)(H,27,28,33) SEXDOMXDYBZSNF-UHFFFAOYSA-N 183253 US9150546, I-424::US9688643, I-424::US9718790, I-0423 P2X purinoceptor 3 Homo sapiens 49.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183253 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183253&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578524 313634653 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504822 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(cc2)C2=CCCC2)n(Cc2ccc(C)cc2)c1=O 265270 US9718790, I-1083 P2X purinoceptor 3 Homo sapiens 125 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265270 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265270&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021015 377004145 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504823 OCCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccnc(c3)C(O)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H20ClN5O6/c25-16-3-1-15(2-4-16)14-30-22(28-23(34)29(11-12-31)24(30)35)27-17-5-7-18(8-6-17)36-19-9-10-26-20(13-19)21(32)33/h1-10,13,31H,11-12,14H2,(H,32,33)(H,27,28,34) XAIGRRVFAZOSHS-UHFFFAOYSA-N 265271 US9718790, I-1797 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265271 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265271&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945278 377004146 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504824 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(CC2(CC2)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C24H24Cl2N4O5/c1-14(2)35-19-8-7-17(11-18(19)26)27-21-28-22(33)30(13-24(9-10-24)20(31)32)23(34)29(21)12-15-3-5-16(25)6-4-15/h3-8,11,14H,9-10,12-13H2,1-2H3,(H,31,32)(H,27,28,33) HBBCEZGDISQHSJ-UHFFFAOYSA-N 183254 US9150546, I-425::US9688643, I-425::US9718790, I-0424 P2X purinoceptor 3 Homo sapiens 16.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183254 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183254&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578673 313634654 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504825 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2cccc(c2)C2=CCCC2)n(Cc2ccc(C)cc2)c1=O 265273 US9718790, I-1084 P2X purinoceptor 3 Homo sapiens 392 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265273 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265273&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021033 377004148 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504826 CCc1nc2ccc(cc2s1)\N=c1/[nH]c(=O)n(CC(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C21H18ClN5O4S/c1-2-17-24-15-8-7-14(9-16(15)32-17)23-19-25-20(30)27(11-18(28)29)21(31)26(19)10-12-3-5-13(22)6-4-12/h3-9H,2,10-11H2,1H3,(H,28,29)(H,23,25,30) AZIYKWWLLBWAQL-UHFFFAOYSA-N 265274 US9718790, I-1798 P2X purinoceptor 3 Homo sapiens 150 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265274 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265274&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020221 377004149 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504827 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(O)c(Cl)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C22H22Cl2N4O5/c1-22(2,18(30)33-3)12-28-20(31)26-19(25-15-8-9-17(29)16(24)10-15)27(21(28)32)11-13-4-6-14(23)7-5-13/h4-10,29H,11-12H2,1-3H3,(H,25,26,31) SXOZPGVWKPWJJP-UHFFFAOYSA-N 183255 US9150546, I-426::US9688643, I-426::US9718790, I-0425 P2X purinoceptor 3 Homo sapiens 211 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183255 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183255&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578584 313634655 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504828 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(cc2)N2CCCCC2)n(Cc2ccc(C)cc2)c1=O 265276 US9718790, I-1085 P2X purinoceptor 3 Homo sapiens 34.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265276 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265276&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021054 377004151 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504829 COc1ccc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(CC(O)=O)c(=O)n2Cc2ccc(Cl)cc2)cn1 InChI=1S/C24H20ClN5O6/c1-35-20-11-10-19(12-26-20)36-18-8-6-17(7-9-18)27-22-28-23(33)30(14-21(31)32)24(34)29(22)13-15-2-4-16(25)5-3-15/h2-12H,13-14H2,1H3,(H,31,32)(H,27,28,33) YDUKEIATPDTYAB-UHFFFAOYSA-N 265277 US9718790, I-1799 P2X purinoceptor 3 Homo sapiens 382 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265277 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265277&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278205 377004152 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504830 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc3n(C)ccc3c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H26ClN5O4/c1-25(2,21(32)35-4)15-31-23(33)28-22(27-19-9-10-20-17(13-19)11-12-29(20)3)30(24(31)34)14-16-5-7-18(26)8-6-16/h5-13H,14-15H2,1-4H3,(H,27,28,33) XYQHDOWUQZVEED-UHFFFAOYSA-N 183256 BDBM265278::US9150546, I-427::US9688643, I-427 P2X purinoceptor 3 Homo sapiens 678 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183256 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183256&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578784 313634656 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504831 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(cc2)N2CCCC2)n(Cc2ccc(C)cc2)c1=O 265279 US9718790, I-1086 P2X purinoceptor 3 Homo sapiens 291 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265279 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265279&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019668 377004154 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504832 Cc1cc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(CC(O)=O)c(=O)n2Cc2ccc(Cl)cc2)ccn1 InChI=1S/C24H20ClN5O5/c1-15-12-20(10-11-26-15)35-19-8-6-18(7-9-19)27-22-28-23(33)30(14-21(31)32)24(34)29(22)13-16-2-4-17(25)5-3-16/h2-12H,13-14H2,1H3,(H,31,32)(H,27,28,33) KACSXDKWSJLNFT-UHFFFAOYSA-N 265280 US9718790, I-1800 P2X purinoceptor 3 Homo sapiens 510 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265280 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265280&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020223 377004155 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504833 CC(C)(Cn1c(=O)[nH]\c(=N/c2ccc(O)c(Cl)c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O InChI=1S/C21H20Cl2N4O5/c1-21(2,17(29)30)11-27-19(31)25-18(24-14-7-8-16(28)15(23)9-14)26(20(27)32)10-12-3-5-13(22)6-4-12/h3-9,28H,10-11H2,1-2H3,(H,29,30)(H,24,25,31) GIRJLUJEDZDUPQ-UHFFFAOYSA-N 183257 US9150546, I-429::US9688643, I-429::US9718790, I-0428 P2X purinoceptor 3 Homo sapiens 779 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183257 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183257&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578463 313634657 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504834 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(cc2)C2CCCCC2)n(Cc2ccc(C)cc2)c1=O 265282 US9718790, I-1087 P2X purinoceptor 3 Homo sapiens 71.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265282 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265282&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945059 377004157 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504835 COC(=O)CCn1c(=O)[nH]\c(=N/Nc2ccc(OC)cc2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C22H25N5O5/c1-15-4-6-16(7-5-15)14-27-20(25-24-17-8-10-18(31-2)11-9-17)23-21(29)26(22(27)30)13-12-19(28)32-3/h4-11,24H,12-14H2,1-3H3,(H,23,25,29) LHWVUSNXHUSETC-UHFFFAOYSA-N 265283 US9718790, I-1801 P2X purinoceptor 3 Homo sapiens 687 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265283 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265283&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019961 377004158 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504836 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H31ClN4O5/c1-16(2)36-21-12-11-20(13-17(21)3)28-23-29-24(33)31(15-26(4,5)22(32)35-6)25(34)30(23)14-18-7-9-19(27)10-8-18/h7-13,16H,14-15H2,1-6H3,(H,28,29,33) HNEFEUVSRBUTDF-UHFFFAOYSA-N 183258 US9150546, I-431::US9688643, I-431::US9718790, I-0430 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183258 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183258&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578498 313634658 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504837 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2cccc(c2)C2CCCCC2)n(Cc2ccc(C)cc2)c1=O 265285 US9718790, I-1088 P2X purinoceptor 3 Homo sapiens 548 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265285 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265285&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019617 377004160 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504838 COC(=O)CCn1c(=O)[nH]\c(=N/c2cn(C)nc2C(=O)NC(C)C)n(Cc2ccc(C)cc2)c1=O InChI=1S/C23H29N7O5/c1-14(2)24-20(32)19-17(13-28(4)27-19)25-21-26-22(33)29(11-10-18(31)35-5)23(34)30(21)12-16-8-6-15(3)7-9-16/h6-9,13-14H,10-12H2,1-5H3,(H,24,32)(H,25,26,33) XGUZGTFPJQIMKK-UHFFFAOYSA-N 265286 US9718790, I-1804 P2X purinoceptor 3 Homo sapiens 162 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265286 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265286&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019963 377004161 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504839 CC(C)Oc1ccc(cc1C)\N=c1/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C25H29ClN4O5/c1-15(2)35-20-11-10-19(12-16(20)3)27-22-28-23(33)30(14-25(4,5)21(31)32)24(34)29(22)13-17-6-8-18(26)9-7-17/h6-12,15H,13-14H2,1-5H3,(H,31,32)(H,27,28,33) QAOVRPBLQVFODI-UHFFFAOYSA-N 183259 US9150546, I-432::US9688643, I-432::US9718790, I-0431 P2X purinoceptor 3 Homo sapiens 26.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183259 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183259&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578521 313634659 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504840 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2cccc(c2)C2CCCC2)n(Cc2ccc(C)cc2)c1=O 265288 US9718790, I-1089 P2X purinoceptor 3 Homo sapiens 487 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265288 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265288&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019566 377004163 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504841 CCc1nc2ccc(cc2s1)\N=c1/[nH]c(=O)n(CC(N)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C21H19ClN6O3S/c1-2-18-25-15-8-7-14(9-16(15)32-18)24-19-26-20(30)28(11-17(23)29)21(31)27(19)10-12-3-5-13(22)6-4-12/h3-9H,2,10-11H2,1H3,(H2,23,29)(H,24,26,30) NDIQWZYLAZYTFS-UHFFFAOYSA-N 265289 US9718790, I-1805 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265289 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265289&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020021 377004164 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504842 COc1nc(=O)n(Cc2ccc(Cl)cc2)\c(=N\c2ccc(OC(C)C)c(Cl)c2)[nH]1 InChI=1S/C20H20Cl2N4O3/c1-12(2)29-17-9-8-15(10-16(17)22)23-18-24-19(28-3)25-20(27)26(18)11-13-4-6-14(21)7-5-13/h4-10,12H,11H2,1-3H3,(H,23,24,25,27) BLXHTNIMBSZEGS-UHFFFAOYSA-N 183260 US9150546, I-433::US9688643, I-433::US9718790, I-0432 P2X purinoceptor 3 Homo sapiens 199 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183260 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183260&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 119099066 313634660 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504843 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(cc2)C2CCCC2)n(Cc2ccc(C)cc2)c1=O 265291 US9718790, I-1090 P2X purinoceptor 3 Homo sapiens 135 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265291 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265291&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019715 377004166 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504844 CCc1nc2ccc(cc2s1)\N=c1/[nH]c(=O)n(CC(=O)NC)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C22H21ClN6O3S/c1-3-19-26-16-9-8-15(10-17(16)33-19)25-20-27-21(31)29(12-18(30)24-2)22(32)28(20)11-13-4-6-14(23)7-5-13/h4-10H,3,11-12H2,1-2H3,(H,24,30)(H,25,27,31) ZRJNRFHEQCHAMZ-UHFFFAOYSA-N 265292 US9718790, I-1807 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265292 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265292&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020482 377004167 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504845 CC(C)Oc1ccc(Nc2nc(OCCO)nc(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C21H22ClFN4O4/c1-13(2)31-18-8-7-16(11-17(18)23)24-19-25-20(30-10-9-28)26-21(29)27(19)12-14-3-5-15(22)6-4-14/h3-8,11,13,28H,9-10,12H2,1-2H3,(H,24,25,26,29) PHCRNZGGIOWYGF-UHFFFAOYSA-N 183261 US9150546, II-002::US9688643, II-002::US9718790, I-0434 P2X purinoceptor 3 Homo sapiens 79.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183261 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183261&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578797 313634661 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504846 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(cc2)N2CCCC2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 265294 US9718790, I-1091 P2X purinoceptor 3 Homo sapiens 179 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265294 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265294&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278178 377004169 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504847 CCc1nc2ccc(cc2s1)\N=c1/[nH]c(=O)n(CC(=O)NCCO)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C23H23ClN6O4S/c1-2-20-27-17-8-7-16(11-18(17)35-20)26-21-28-22(33)30(13-19(32)25-9-10-31)23(34)29(21)12-14-3-5-15(24)6-4-14/h3-8,11,31H,2,9-10,12-13H2,1H3,(H,25,32)(H,26,28,33) QASFWUNXYYWGQB-UHFFFAOYSA-N 265295 US9718790, I-1808 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265295 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265295&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020562 377004170 C04080 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504848 CC(C)Oc1ccc(Nc2nc(OCCCO)nc(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C22H24ClFN4O4/c1-14(2)32-19-9-8-17(12-18(19)24)25-20-26-21(31-11-3-10-29)27-22(30)28(20)13-15-4-6-16(23)7-5-15/h4-9,12,14,29H,3,10-11,13H2,1-2H3,(H,25,26,27,30) CODUWDUTHTZBMI-UHFFFAOYSA-N 183262 US9150546, II-006::US9688643, II-006::US9718790, I-0438 P2X purinoceptor 3 Homo sapiens 398 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183262 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183262&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578709 313634662 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504849 CC(C)Oc1ccc(cc1)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(I)cc1 265297 US9718790, I-1092 P2X purinoceptor 3 Homo sapiens 69.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265297 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265297&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278221 377004172 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504850 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n(CCC(O)=O)c(=O)n1CC1(C)CCCCC1 InChI=1S/C23H31FN4O5/c1-15(2)33-18-8-7-16(13-17(18)24)25-20-26-21(31)27(12-9-19(29)30)22(32)28(20)14-23(3)10-5-4-6-11-23/h7-8,13,15H,4-6,9-12,14H2,1-3H3,(H,29,30)(H,25,26,31) VCVCNSSCEWXQPC-UHFFFAOYSA-N 265298 US9718790, I-1809 P2X purinoceptor 3 Homo sapiens 339 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265298 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265298&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020495 377004173 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504851 CC(C)Oc1ccc(Nc2nc(OCC(CO)CO)nc(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C23H26ClFN4O5/c1-14(2)34-20-8-7-18(9-19(20)25)26-21-27-22(33-13-16(11-30)12-31)28-23(32)29(21)10-15-3-5-17(24)6-4-15/h3-9,14,16,30-31H,10-13H2,1-2H3,(H,26,27,28,32) LYDDBGQLQCSRHN-UHFFFAOYSA-N 183263 US9150546, II-008::US9688643, II-008::US9718790, I-0440 P2X purinoceptor 3 Homo sapiens 943 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183263 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183263&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578799 313634663 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504852 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(cc2)N2CCCCC2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 265300 US9718790, I-1093 P2X purinoceptor 3 Homo sapiens 38.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265300 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265300&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278222 377004175 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504853 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc3COCCc3c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 265301 US9718790, I-1810 P2X purinoceptor 3 Homo sapiens 682 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265301 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265301&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020501 377004176 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504854 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(OCC(O)=O)nc(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C21H20Cl2N4O5/c1-12(2)32-17-8-7-15(9-16(17)23)24-19-25-20(31-11-18(28)29)26-21(30)27(19)10-13-3-5-14(22)6-4-13/h3-9,12H,10-11H2,1-2H3,(H,28,29)(H,24,25,26,30) AIQQRNKMARTPQG-UHFFFAOYSA-N 183264 US9150546, II-009::US9688643, II-009::US9718790, I-0441 P2X purinoceptor 3 Homo sapiens 34.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183264 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183264&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 119099067 313634664 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504855 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(C=C3CCCC3)cc2)n(Cc2ccc(C)cc2)c1=O 265303 US9718790, I-1094 P2X purinoceptor 3 Homo sapiens 103 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265303 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265303&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278223 377004178 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504856 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc3n(C)c(nc3c2)-c2ccccc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 265304 US9718790, I-1812 P2X purinoceptor 3 Homo sapiens 630 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265304 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265304&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019953 377004179 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504857 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(OCC(C)(C)C(O)=O)nc(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C24H26Cl2N4O5/c1-14(2)35-19-10-9-17(11-18(19)26)27-21-28-22(34-13-24(3,4)20(31)32)29-23(33)30(21)12-15-5-7-16(25)8-6-15/h5-11,14H,12-13H2,1-4H3,(H,31,32)(H,27,28,29,33) JDUIQMJXOFCZDY-UHFFFAOYSA-N 183265 US9150546, II-010::US9688643, II-010::US9718790, I-0442 P2X purinoceptor 3 Homo sapiens 349 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183265 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183265&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 119099068 313634665 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504858 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(C=C3CCCC3)cc2)n(Cc2ccc(Cl)cc2)c1=O 265306 US9718790, I-1095 P2X purinoceptor 3 Homo sapiens 144 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265306 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265306&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945269 377004181 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504859 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc3oc(nc3c2)-c2ccccc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 265307 US9718790, I-1814 P2X purinoceptor 3 Homo sapiens 299 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265307 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265307&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945249 377004182 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504860 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(CC(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C21H20Cl2N4O5/c1-12(2)32-17-8-7-15(9-16(17)23)24-19-25-20(30)27(11-18(28)29)21(31)26(19)10-13-3-5-14(22)6-4-13/h3-9,12H,10-11H2,1-2H3,(H,28,29)(H,24,25,30) VEMXKDNCOMOECJ-UHFFFAOYSA-N 183266 US9150546, I-434::US9688643, I-434::US9718790, I-0443 P2X purinoceptor 3 Homo sapiens 407 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183266 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183266&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578367 313634666 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504861 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(CC3CCCC3)cc2)n(Cc2ccc(C)cc2)c1=O 265309 US9718790, I-1096 P2X purinoceptor 3 Homo sapiens 94.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265309 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265309&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019663 377004184 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504862 CCn1c2ccccc2c2cc(ccc12)\N=c1/[nH]c(=O)n([C@@H](C)[C@@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 265310 US9718790, I-1815 P2X purinoceptor 3 Homo sapiens 367 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265310 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265310&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020013 377004185 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504863 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(CC(=O)NCC#N)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C23H22Cl2N6O4/c1-14(2)35-19-8-7-17(11-18(19)25)28-21-29-22(33)31(13-20(32)27-10-9-26)23(34)30(21)12-15-3-5-16(24)6-4-15/h3-8,11,14H,10,12-13H2,1-2H3,(H,27,32)(H,28,29,33) YIKMIGBCKDVAHZ-UHFFFAOYSA-N 183267 US9150546, I-435::US9688643, I-435::US9718790, I-0444 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183267 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183267&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 88558797 313634667 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505294 OCC(CO)Cn1c(=O)[nH]\c(=N/c2ccc3nc(sc3c2)C2CC2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H24ClN5O4S/c25-17-5-1-14(2-6-17)10-29-22(28-23(33)30(24(29)34)11-15(12-31)13-32)26-18-7-8-19-20(9-18)35-21(27-19)16-3-4-16/h1-2,5-9,15-16,31-32H,3-4,10-13H2,(H,26,28,33) HVHHWUXPRLPKIN-UHFFFAOYSA-N 265732 US9718790, I-1983 P2X purinoceptor 3 Homo sapiens 10.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265732 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265732&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020619 377004604 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505295 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n(CCC(=O)NO)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C22H23ClFN5O5/c1-13(2)34-18-8-7-16(11-17(18)24)25-20-26-21(31)28(10-9-19(30)27-33)22(32)29(20)12-14-3-5-15(23)6-4-14/h3-8,11,13,33H,9-10,12H2,1-2H3,(H,27,30)(H,25,26,31) QSTFNQSSNOCTRR-UHFFFAOYSA-N 265733 US9718790, I-0603 P2X purinoceptor 3 Homo sapiens 12.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265733 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265733&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 88558730 377004605 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505296 CC(C)Cc1ccc(cc1C)\N=c1/[nH]c(=O)n(CCC(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C24H27ClN4O4/c1-15(2)12-18-6-9-20(13-16(18)3)26-22-27-23(32)28(11-10-21(30)31)24(33)29(22)14-17-4-7-19(25)8-5-17/h4-9,13,15H,10-12,14H2,1-3H3,(H,30,31)(H,26,27,32) NBXDGAJHFYYBIO-UHFFFAOYSA-N 265734 US9718790, I-1255 P2X purinoceptor 3 Homo sapiens 48.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265734 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265734&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019898 377004606 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505297 COc1cc(ccc1OC(C)C)\N=c1/[nH]c(=O)n(CC2COC(C)(C)OC2)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C27H33ClN4O6/c1-17(2)38-22-11-10-21(12-23(22)35-5)29-24-30-25(33)32(14-19-15-36-27(3,4)37-16-19)26(34)31(24)13-18-6-8-20(28)9-7-18/h6-12,17,19H,13-16H2,1-5H3,(H,29,30,33) NNDWYEWYUJFSES-UHFFFAOYSA-N 265735 US9718790, I-1984 P2X purinoceptor 3 Homo sapiens 9.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265735 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265735&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020518 377004607 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505298 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n([C@@H]2C[C@H]2C(=O)OC(C)(C)C)c(=O)n1Cc1ccc(Cl)cc1 265736 US9718790, I-0604 P2X purinoceptor 3 Homo sapiens 13.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265736 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265736&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117756378 377004608 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505299 CC(C)Cc1ccc(cc1F)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(C)cc1 265737 US9718790, I-1256 P2X purinoceptor 3 Homo sapiens 18.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265737 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265737&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020436 377004609 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505300 COc1cc(ccc1OC(C)C)\N=c1/[nH]c(=O)n(CC(CO)CO)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C24H29ClN4O6/c1-15(2)35-20-9-8-19(10-21(20)34-3)26-22-27-23(32)29(12-17(13-30)14-31)24(33)28(22)11-16-4-6-18(25)7-5-16/h4-10,15,17,30-31H,11-14H2,1-3H3,(H,26,27,32) WGZSZTLWQRKFHZ-UHFFFAOYSA-N 265738 US9718790, I-1985 P2X purinoceptor 3 Homo sapiens 11.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265738 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265738&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020514 377004610 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505301 CCOc1ccc(cc1F)\N=c1/[nH]c(=O)n(C[C@H](C)C(=O)OC)c(=O)n1Cc1ccc(C)cc1 265739 US9718790, I-0605 P2X purinoceptor 3 Homo sapiens 25.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265739 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265739&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945018 377004611 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505302 CC(C)Cc1ccc(cc1F)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 265740 US9718790, I-1257 P2X purinoceptor 3 Homo sapiens 9.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265740 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265740&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020511 377004612 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505303 OCCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccnc(CO)c3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H22ClN5O5/c25-17-3-1-16(2-4-17)14-30-22(28-23(33)29(11-12-31)24(30)34)27-18-5-7-20(8-6-18)35-21-9-10-26-19(13-21)15-32/h1-10,13,31-32H,11-12,14-15H2,(H,27,28,33) HYQMSUUBIUZZHF-UHFFFAOYSA-N 265741 US9718790, I-1986 P2X purinoceptor 3 Homo sapiens 16.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265741 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265741&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945618 377004613 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505304 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)cc2)n(Cc2ccc(C)cc2)c1=O 265742 US9718790, I-0606 P2X purinoceptor 3 Homo sapiens 21.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265742 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265742&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019763 377004614 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505305 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2cccc(c2)C(F)(F)F)n(Cc2ccc(C)cc2)c1=O InChI=1S/C24H25F3N4O4/c1-15-8-10-16(11-9-15)13-30-20(28-18-7-5-6-17(12-18)24(25,26)27)29-21(33)31(22(30)34)14-23(2,3)19(32)35-4/h5-12H,13-14H2,1-4H3,(H,28,29,33) WTFKHMGXNIXWQX-UHFFFAOYSA-N 265743 US9718790, I-1258 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265743 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265743&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278183 377004615 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505306 Cc1cc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(C[C@H](O)CO)c(=O)n2Cc2ccc(Cl)cc2)ccn1 265744 US9718790, I-1987 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265744 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265744&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021031 377004616 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505307 COC(=O)NCCn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H25ClFN5O5/c1-14(2)35-19-9-8-17(12-18(19)25)27-20-28-21(31)29(11-10-26-22(32)34-3)23(33)30(20)13-15-4-6-16(24)7-5-15/h4-9,12,14H,10-11,13H2,1-3H3,(H,26,32)(H,27,28,31) RAVLOBSVGRPLBP-UHFFFAOYSA-N 265745 US9718790, I-0607 P2X purinoceptor 3 Homo sapiens 12.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265745 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265745&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019619 377004617 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505308 OC(=O)CCCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccncc3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H22ClN5O5/c26-18-5-3-17(4-6-18)16-31-23(29-24(34)30(25(31)35)15-1-2-22(32)33)28-19-7-9-20(10-8-19)36-21-11-13-27-14-12-21/h3-14H,1-2,15-16H2,(H,32,33)(H,28,29,34) GFTYXVZISFFXFO-UHFFFAOYSA-N 265746 US9718790, I-1259 P2X purinoceptor 3 Homo sapiens 11.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265746 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265746&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020447 377004618 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505309 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccc3C(=O)OC)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H23ClN4O5/c1-3-30-25(33)29-24(31(26(30)34)16-17-8-10-18(27)11-9-17)28-19-12-14-20(15-13-19)36-22-7-5-4-6-21(22)23(32)35-2/h4-15H,3,16H2,1-2H3,(H,28,29,33) RNKLSRUCICJOFW-UHFFFAOYSA-N 265747 US9718790, I-1988 P2X purinoceptor 3 Homo sapiens 391 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265747 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265747&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278593 377004619 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505310 COC(=O)NCCCn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H27ClFN5O5/c1-15(2)36-20-10-9-18(13-19(20)26)28-21-29-22(32)30(12-4-11-27-23(33)35-3)24(34)31(21)14-16-5-7-17(25)8-6-16/h5-10,13,15H,4,11-12,14H2,1-3H3,(H,27,33)(H,28,29,32) ZVRVOUXGSBJWNX-UHFFFAOYSA-N 265748 US9718790, I-0608 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265748 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265748&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019755 377004620 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505311 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cc(C)nc(C)c3)cc2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 265749 US9718790, I-1260 P2X purinoceptor 3 Homo sapiens 31.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265749 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265749&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020468 377004621 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505312 CCOC(=O)COc1ccc(cc1)\N=c1/[nH]c(=O)n(CC)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C22H23ClN4O5/c1-3-26-21(29)25-20(27(22(26)30)13-15-5-7-16(23)8-6-15)24-17-9-11-18(12-10-17)32-14-19(28)31-4-2/h5-12H,3-4,13-14H2,1-2H3,(H,24,25,29) QYNVCOLNGPPXTQ-UHFFFAOYSA-N 265750 US9718790, I-1989 P2X purinoceptor 3 Homo sapiens 619 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265750 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265750&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278385 377004622 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505313 CCOc1ccc(cc1F)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 265751 US9718790, I-0609 P2X purinoceptor 3 Homo sapiens 31.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265751 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265751&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019701 377004623 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505314 COc1cc(ccc1CC(C)C)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(C)cc1 265752 US9718790, I-1261 P2X purinoceptor 3 Homo sapiens 18.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265752 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265752&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020033 377004624 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505315 CCOC(=O)CCn1c(=O)[nH]\c(=N/c2ccc3nc(C)sc3c2)n(CC2CCC(C)CC2)c1=O InChI=1S/C24H31N5O4S/c1-4-33-21(30)11-12-28-23(31)27-22(26-18-9-10-19-20(13-18)34-16(3)25-19)29(24(28)32)14-17-7-5-15(2)6-8-17/h9-10,13,15,17H,4-8,11-12,14H2,1-3H3,(H,26,27,31) XZAMDCPIHWIQIP-UHFFFAOYSA-N 265753 US9718790, I-1990 P2X purinoceptor 3 Homo sapiens 2.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265753 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265753&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021039 377004625 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505316 CCOc1ccc(cc1F)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(C)cc1 265754 US9718790, I-0610 P2X purinoceptor 3 Homo sapiens 35.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265754 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265754&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019757 377004626 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505317 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Cc3ccncc3)cc2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 265755 US9718790, I-1262 P2X purinoceptor 3 Homo sapiens 163 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265755 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265755&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020156 377004627 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505318 CCOC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(Cl)c2)n(CC2CCC(C)CC2)c1=O InChI=1S/C25H35ClN4O5/c1-5-34-22(31)12-13-29-24(32)28-23(27-19-10-11-21(20(26)14-19)35-16(2)3)30(25(29)33)15-18-8-6-17(4)7-9-18/h10-11,14,16-18H,5-9,12-13,15H2,1-4H3,(H,27,28,32) WCJLIWKQOHSMIT-UHFFFAOYSA-N 265756 US9718790, I-1991 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265756 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265756&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020528 377004628 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505319 CC(C)Oc1ccc(cc1)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(C)cc1 265757 US9718790, I-0611 P2X purinoceptor 3 Homo sapiens 37.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265757 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265757&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020376 377004629 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505320 CC(C)(Cn1c(=O)[nH]\c(=N/c2ccc(OCC3CC3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O InChI=1S/C25H27ClN4O5/c1-25(2,21(31)32)15-30-23(33)28-22(29(24(30)34)13-16-5-7-18(26)8-6-16)27-19-9-11-20(12-10-19)35-14-17-3-4-17/h5-12,17H,3-4,13-15H2,1-2H3,(H,31,32)(H,27,28,33) JKTBTKBAWLIWKW-UHFFFAOYSA-N 265758 US9718790, I-1263 P2X purinoceptor 3 Homo sapiens 25.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265758 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265758&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945239 377004630 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505321 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccc3C(O)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H21ClN4O5/c1-2-29-24(33)28-23(30(25(29)34)15-16-7-9-17(26)10-8-16)27-18-11-13-19(14-12-18)35-21-6-4-3-5-20(21)22(31)32/h3-14H,2,15H2,1H3,(H,31,32)(H,27,28,33) CENYZCRAHXDGLK-UHFFFAOYSA-N 265759 US9718790, I-1992 P2X purinoceptor 3 Homo sapiens 240 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265759 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265759&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020566 377004631 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505322 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n([C@@H]2C[C@H]2C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 265760 US9718790, I-0612 P2X purinoceptor 3 Homo sapiens 38.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265760 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265760&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278156 377004632 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505323 COc1cc(ccc1OC(C)C)\N=c1/[nH]c(=O)n(CCC(O)=O)c(=O)n1Cc1ccc(C)cc1 InChI=1S/C24H28N4O6/c1-15(2)34-19-10-9-18(13-20(19)33-4)25-22-26-23(31)27(12-11-21(29)30)24(32)28(22)14-17-7-5-16(3)6-8-17/h5-10,13,15H,11-12,14H2,1-4H3,(H,29,30)(H,25,26,31) MVQGMJPLVAKSKJ-UHFFFAOYSA-N 265761 US9718790, I-1264 P2X purinoceptor 3 Homo sapiens 31.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265761 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265761&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020034 377004633 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505324 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(cc3)S(N)(=O)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H22ClN5O5S/c1-2-29-23(31)28-22(30(24(29)32)15-16-3-5-17(25)6-4-16)27-18-7-9-19(10-8-18)35-20-11-13-21(14-12-20)36(26,33)34/h3-14H,2,15H2,1H3,(H2,26,33,34)(H,27,28,31) HOAJVNYBCSGTOV-UHFFFAOYSA-N 265762 US9718790, I-1993 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265762 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265762&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278312 377004634 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505325 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n(CCCN\C(Oc2ccccc2)=N/C#N)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C30H29ClFN7O4/c1-20(2)42-26-14-13-23(17-25(26)32)36-27-37-29(40)38(30(41)39(27)18-21-9-11-22(31)12-10-21)16-6-15-34-28(35-19-33)43-24-7-4-3-5-8-24/h3-5,7-14,17,20H,6,15-16,18H2,1-2H3,(H,34,35)(H,36,37,40) SFAHGGRSICLTBX-UHFFFAOYSA-N 265763 US9718790, I-0613 P2X purinoceptor 3 Homo sapiens 11.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265763 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265763&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278237 377004635 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505326 COc1cc(ccc1OC(C)C)\N=c1/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C25H29ClN4O6/c1-15(2)36-19-11-10-18(12-20(19)35-5)27-22-28-23(33)30(14-25(3,4)21(31)32)24(34)29(22)13-16-6-8-17(26)9-7-16/h6-12,15H,13-14H2,1-5H3,(H,31,32)(H,27,28,33) KPENBEBVOVCOMH-UHFFFAOYSA-N 265764 US9718790, I-1265 P2X purinoceptor 3 Homo sapiens 22.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265764 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265764&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 89667020 377004636 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505327 CC1CCC(Cn2c(=O)n(CCC(O)=O)c(=O)[nH]\c2=N/c2ccc3nc(C)sc3c2)CC1 InChI=1S/C22H27N5O4S/c1-13-3-5-15(6-4-13)12-27-20(25-21(30)26(22(27)31)10-9-19(28)29)24-16-7-8-17-18(11-16)32-14(2)23-17/h7-8,11,13,15H,3-6,9-10,12H2,1-2H3,(H,28,29)(H,24,25,30) SJZITDUYBKNGQA-UHFFFAOYSA-N 265765 US9718790, I-1994 P2X purinoceptor 3 Homo sapiens 10.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265765 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265765&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020573 377004637 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505328 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(C[C@@H]2COC(C)(C)O2)c(=O)n1Cc1ccc(Cl)cc1 265766 US9718790, I-0614 P2X purinoceptor 3 Homo sapiens 10.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265766 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265766&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 86689088 377004638 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505329 COc1cc(ccc1OC(C)C)\N=c1/[nH]c(=O)n(CC(=O)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C23H23ClN4O7/c1-13(2)35-18-9-8-16(10-19(18)34-3)25-21-26-22(32)28(12-17(29)20(30)31)23(33)27(21)11-14-4-6-15(24)7-5-14/h4-10,13H,11-12H2,1-3H3,(H,30,31)(H,25,26,32) FPUZKISJLBHKQQ-UHFFFAOYSA-N 265767 US9718790, I-1266 P2X purinoceptor 3 Homo sapiens 49.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265767 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265767&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278499 377004639 C00972 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505330 OCCCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccnc(CO)c3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H24ClN5O5/c26-18-4-2-17(3-5-18)15-31-23(29-24(34)30(25(31)35)12-1-13-32)28-19-6-8-21(9-7-19)36-22-10-11-27-20(14-22)16-33/h2-11,14,32-33H,1,12-13,15-16H2,(H,28,29,34) FTIXPJIIRLTPEV-UHFFFAOYSA-N 265768 US9718790, I-1995 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265768 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265768&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945679 377004640 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505331 CNC(NCCCn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O)=NC#N InChI=1S/C25H28ClFN8O3/c1-16(2)38-21-10-9-19(13-20(21)27)32-23-33-24(36)34(12-4-11-30-22(29-3)31-15-28)25(37)35(23)14-17-5-7-18(26)8-6-17/h5-10,13,16H,4,11-12,14H2,1-3H3,(H2,29,30,31)(H,32,33,36) LSLPYHVMODXGFH-UHFFFAOYSA-N 265769 US9718790, I-0615 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265769 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265769&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 88558895 377004641 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505332 CCCc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(C)cc1 265770 US9718790, I-1267 P2X purinoceptor 3 Homo sapiens 9.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265770 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265770&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020895 377004642 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505333 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cncc(c3)C(N)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H21ClN6O4/c1-2-30-23(33)29-22(31(24(30)34)14-15-3-5-17(25)6-4-15)28-18-7-9-19(10-8-18)35-20-11-16(21(26)32)12-27-13-20/h3-13H,2,14H2,1H3,(H2,26,32)(H,28,29,33) GEAQDYJJVNWFJW-UHFFFAOYSA-N 265771 US9718790, I-1996 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265771 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265771&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278414 377004643 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505334 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(C[C@@H](O)CO)c(=O)n1Cc1ccc(Cl)cc1 265772 US9718790, I-0616 P2X purinoceptor 3 Homo sapiens 10.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265772 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265772&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 86689090 377004644 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505335 Cc1ccc(Cn2c(=O)n(CC(C)(C)C(O)=O)c(=O)[nH]\c2=N/c2ccc(OCC3CC3)cc2)cc1 InChI=1S/C26H30N4O5/c1-17-4-6-18(7-5-17)14-29-23(27-20-10-12-21(13-11-20)35-15-19-8-9-19)28-24(33)30(25(29)34)16-26(2,3)22(31)32/h4-7,10-13,19H,8-9,14-16H2,1-3H3,(H,31,32)(H,27,28,33) URSMBXCYMBPMEO-UHFFFAOYSA-N 265773 US9718790, I-1268 P2X purinoceptor 3 Homo sapiens 52.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265773 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265773&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945217 377004645 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505336 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccnc(c3)C(N)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H21ClN6O4/c1-2-30-23(33)29-22(31(24(30)34)14-15-3-5-16(25)6-4-15)28-17-7-9-18(10-8-17)35-19-11-12-27-20(13-19)21(26)32/h3-13H,2,14H2,1H3,(H2,26,32)(H,28,29,33) FZFLCFKPTAWZCO-UHFFFAOYSA-N 265774 US9718790, I-1997 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265774 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265774&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278420 377004646 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505337 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(F)c2)n(Cc2ccc(F)cc2)c1=O 265775 US9718790, I-0617 P2X purinoceptor 3 Homo sapiens 67.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265775 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265775&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278157 377004647 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505338 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccnc(C)c3)cc2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 265776 US9718790, I-1269 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265776 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265776&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020856 377004648 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505339 C[C@@H](Oc1ccc(cc1)\N=c1/[nH]c(=O)n(CCC(=O)NCCO)c(=O)n1Cc1ccc(Cl)cc1)C(F)(F)F 265777 US9718790, I-1998 P2X purinoceptor 3 Homo sapiens 34.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265777 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265777&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278421 377004649 C04080 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505340 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)cc2)n(Cc2ccc(F)cc2)c1=O 265778 US9718790, I-0618 P2X purinoceptor 3 Homo sapiens 121 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265778 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265778&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020441 377004650 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505341 COc1cc(ccc1CC(C)C)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 265779 US9718790, I-1270 P2X purinoceptor 3 Homo sapiens 12.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265779 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265779&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020876 377004651 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505342 C[C@@H](Oc1ccc(cc1)\N=c1/[nH]c(=O)n(CC(=O)NCCO)c(=O)n1Cc1ccc(Cl)cc1)C(F)(F)F 265780 US9718790, I-1999 P2X purinoceptor 3 Homo sapiens 28.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265780 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265780&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945294 377004652 C04080 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505343 CCCOc1ccc(cc1)\N=c1/[nH]c(=O)n(C[C@H](C)C(=O)OC)c(=O)n1Cc1ccc(Cl)cc1 265781 US9718790, I-0619 P2X purinoceptor 3 Homo sapiens 14.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265781 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265781&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945034 377004653 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505344 Cc1ccc(Cn2\c(=N\c3cccc(c3)C(F)(F)F)[nH]c(=O)n(CC(C)(C)C(O)=O)c2=O)cc1 InChI=1S/C23H23F3N4O4/c1-14-7-9-15(10-8-14)12-29-19(27-17-6-4-5-16(11-17)23(24,25)26)28-20(33)30(21(29)34)13-22(2,3)18(31)32/h4-11H,12-13H2,1-3H3,(H,31,32)(H,27,28,33) GSNGKYFIFFRYLJ-UHFFFAOYSA-N 265782 US9718790, I-1271 P2X purinoceptor 3 Homo sapiens 32.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265782 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265782&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945114 377004654 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505345 COc1cc(ccc1OC(C)C)\N=c1/[nH]c(=O)n(CCCOC2CCCCO2)c(=O)n1Cc1ccc(Cl)cc1 265783 US9718790, I-2000 P2X purinoceptor 3 Homo sapiens 3.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265783 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265783&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945671 377004655 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505346 CCCCc1ccc(cc1)\N=c1/[nH]c(=O)n(C[C@H](C)C(=O)OC)c(=O)n1Cc1ccc(Cl)cc1 265784 US9718790, I-0620 P2X purinoceptor 3 Homo sapiens 44.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265784 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265784&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118944970 377004656 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505347 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(OC)c2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C27H34N4O6/c1-17(2)37-21-13-12-20(14-22(21)35-6)28-24-29-25(33)31(16-27(4,5)23(32)36-7)26(34)30(24)15-19-10-8-18(3)9-11-19/h8-14,17H,15-16H2,1-7H3,(H,28,29,33) ZPBAUGZYWJWVIW-UHFFFAOYSA-N 265785 US9718790, I-1272 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265785 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265785&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278320 377004657 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505348 COc1cc(ccc1OC(C)C)\N=c1/[nH]c(=O)n(C[C@H]2COC(C)(C)O2)c(=O)n1Cc1ccc(Cl)cc1 265786 US9718790, I-2001 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265786 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265786&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021116 377004658 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505349 CCCc1ccc(cc1)\N=c1/[nH]c(=O)n(C[C@H](C)C(=O)OC)c(=O)n1Cc1ccc(Cl)cc1 265787 US9718790, I-0621 P2X purinoceptor 3 Homo sapiens 58.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265787 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265787&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020079 377004659 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505350 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(OC)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H31ClN4O6/c1-16(2)37-20-12-11-19(13-21(20)35-5)28-23-29-24(33)31(15-26(3,4)22(32)36-6)25(34)30(23)14-17-7-9-18(27)10-8-17/h7-13,16H,14-15H2,1-6H3,(H,28,29,33) DGGYSUDEAUUEDL-UHFFFAOYSA-N 265788 US9718790, I-1273 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265788 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265788&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945006 377004660 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505351 COc1cc(ccc1OC(C)C)\N=c1/[nH]c(=O)n(CCCO)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C23H27ClN4O5/c1-15(2)33-19-10-9-18(13-20(19)32-3)25-21-26-22(30)27(11-4-12-29)23(31)28(21)14-16-5-7-17(24)8-6-16/h5-10,13,15,29H,4,11-12,14H2,1-3H3,(H,25,26,30) JKANSKKWJNKEQU-UHFFFAOYSA-N 265789 US9718790, I-2002 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265789 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265789&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021186 377004661 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505352 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2cccc(c2)C(F)(F)F)n(Cc2ccc(Cl)cc2)c1=O 265790 US9718790, I-0622 P2X purinoceptor 3 Homo sapiens 30.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265790 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265790&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278259 377004662 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505353 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccnc(C)c3)cc2)n(Cc2ccc(C)cc2)c1=O 265791 US9718790, I-1274 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265791 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265791&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945096 377004663 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505354 COc1cc(ccc1OC(C)C)\N=c1/[nH]c(=O)n(C[C@H](O)CO)c(=O)n1Cc1ccc(Cl)cc1 265792 US9718790, I-2004 P2X purinoceptor 3 Homo sapiens 13.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265792 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265792&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021118 377004664 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505355 CCCOc1ccc(cc1)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 265793 US9718790, I-0623 P2X purinoceptor 3 Homo sapiens 20.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265793 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265793&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945147 377004665 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505356 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc3nc(C)ccc3c2)n(Cc2ccc(C)cc2)c1=O 265794 US9718790, I-1275 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265794 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265794&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019570 377004666 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505357 COc1cc(ccc1OC(C)C)\N=c1/[nH]c(=O)n(CCOC2CCCCO2)c(=O)n1Cc1ccc(Cl)cc1 265795 US9718790, I-2005 P2X purinoceptor 3 Homo sapiens 3.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265795 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265795&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021188 377004667 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505358 CCCCc1ccc(cc1)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 265796 US9718790, I-0624 P2X purinoceptor 3 Homo sapiens 42.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265796 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265796&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278158 377004668 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505359 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc3nc(C)oc3c2)n(Cc2ccc(C)cc2)c1=O 265797 US9718790, I-1276 P2X purinoceptor 3 Homo sapiens 78.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265797 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265797&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945464 377004669 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505492 CCOc1cc(F)c(\N=c2/[nH]c(=O)n(CCC(O)=O)c(=O)n2Cc2ccc(C)cc2)c(F)c1 InChI=1S/C22H22F2N4O5/c1-3-33-15-10-16(23)19(17(24)11-15)25-20-26-21(31)27(9-8-18(29)30)22(32)28(20)12-14-6-4-13(2)5-7-14/h4-7,10-11H,3,8-9,12H2,1-2H3,(H,29,30)(H,25,26,31) RCAYVEDSLUAROD-UHFFFAOYSA-N 265930 US9718790, I-2053 P2X purinoceptor 3 Homo sapiens 952 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265930 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265930&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945360 377004802 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505493 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(C)c2)n(Cc2ccc(C)cc2)c1=O 265931 US9718790, I-0670 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265931 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265931&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020867 377004803 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505494 CCOC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(OC3CCC3)c(Cl)c2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C26H29ClN4O5/c1-3-35-23(32)13-14-30-25(33)29-24(31(26(30)34)16-18-9-7-17(2)8-10-18)28-19-11-12-22(21(27)15-19)36-20-5-4-6-20/h7-12,15,20H,3-6,13-14,16H2,1-2H3,(H,28,29,33) YGYRGTFXTILDPK-UHFFFAOYSA-N 265932 US9718790, I-1328 P2X purinoceptor 3 Homo sapiens 12.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265932 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265932&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945481 377004804 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505495 Cc1ccc(Cn2c(=O)n(CCC(O)=O)c(=O)[nH]\c2=N/c2cccc(Cl)c2F)cc1 InChI=1S/C20H18ClFN4O4/c1-12-5-7-13(8-6-12)11-26-18(23-15-4-2-3-14(21)17(15)22)24-19(29)25(20(26)30)10-9-16(27)28/h2-8H,9-11H2,1H3,(H,27,28)(H,23,24,29) QLUGVSJRMUKIQJ-UHFFFAOYSA-N 265933 US9718790, I-2054 P2X purinoceptor 3 Homo sapiens 611 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265933 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265933&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278423 377004805 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505496 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc3oc(C)cc3c2)n(Cc2ccc(C)cc2)c1=O 265934 US9718790, I-0671 P2X purinoceptor 3 Homo sapiens 15.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265934 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265934&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019704 377004806 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505497 COC(=O)[C@H](C)[C@H](C)n1c(=O)[nH]\c(=N/c2ccc(OCC(C)C)cc2)n(Cc2ccc(Cl)cc2)c1=O 265935 US9718790, I-1329 P2X purinoceptor 3 Homo sapiens 49.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265935 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265935&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278322 377004807 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505498 Cc1ccc(Cn2c(=O)n(C)c(=O)[nH]\c2=N/c2ccc(Oc3ccnc(CO)c3)cc2)cc1 InChI=1S/C24H23N5O4/c1-16-3-5-17(6-4-16)14-29-22(27-23(31)28(2)24(29)32)26-18-7-9-20(10-8-18)33-21-11-12-25-19(13-21)15-30/h3-13,30H,14-15H2,1-2H3,(H,26,27,31) NRUSOTJMXVEFKX-UHFFFAOYSA-N 265936 US9718790, I-2056 P2X purinoceptor 3 Homo sapiens 26.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265936 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265936&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019972 377004808 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505499 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n(CCc2ncn[nH]2)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C23H23ClFN7O3/c1-14(2)35-19-8-7-17(11-18(19)25)28-21-29-22(33)31(10-9-20-26-13-27-30-20)23(34)32(21)12-15-3-5-16(24)6-4-15/h3-8,11,13-14H,9-10,12H2,1-2H3,(H,26,27,30)(H,28,29,33) GXAFLNJRFCAUCP-UHFFFAOYSA-N 265937 US9718790, I-0672 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265937 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265937&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 86689094 377004809 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505500 CCOC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(OC3CCC3)c(Cl)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H26Cl2N4O5/c1-2-35-22(32)12-13-30-24(33)29-23(31(25(30)34)15-16-6-8-17(26)9-7-16)28-18-10-11-21(20(27)14-18)36-19-4-3-5-19/h6-11,14,19H,2-5,12-13,15H2,1H3,(H,28,29,33) PLGUVODFBRYURG-UHFFFAOYSA-N 265938 US9718790, I-1330 P2X purinoceptor 3 Homo sapiens 9.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265938 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265938&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020872 377004810 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505501 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(F)c(c3)C(=O)OC)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H22ClFN4O5/c1-3-31-25(34)30-24(32(26(31)35)15-16-4-6-17(27)7-5-16)29-18-8-10-19(11-9-18)37-20-12-13-22(28)21(14-20)23(33)36-2/h4-14H,3,15H2,1-2H3,(H,29,30,34) QNMXCCSTIADWRY-UHFFFAOYSA-N 265939 US9718790, I-2057 P2X purinoceptor 3 Homo sapiens 21.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265939 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265939&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945401 377004811 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505502 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(CC(=O)OC2CCOCC2)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C26H28Cl2N4O6/c1-16(2)37-22-8-7-19(13-21(22)28)29-24-30-25(34)32(15-23(33)38-20-9-11-36-12-10-20)26(35)31(24)14-17-3-5-18(27)6-4-17/h3-8,13,16,20H,9-12,14-15H2,1-2H3,(H,29,30,34) YLTUXPMCBDKYTB-UHFFFAOYSA-N 265940 US9718790, I-0673 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265940 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265940&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019880 377004812 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505503 COC(=O)[C@H](C)[C@H](C)n1c(=O)[nH]\c(=N/c2ccc(OCC(C)C)cc2)n(Cc2ccc(C)cc2)c1=O 265941 US9718790, I-1331 P2X purinoceptor 3 Homo sapiens 56.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265941 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265941&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945500 377004813 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505504 COC(=O)c1ccc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(C)c(=O)n2Cc2ccc(Cl)cc2)cc1 InChI=1S/C25H21ClN4O5/c1-29-24(32)28-23(30(25(29)33)15-16-3-7-18(26)8-4-16)27-19-9-13-21(14-10-19)35-20-11-5-17(6-12-20)22(31)34-2/h3-14H,15H2,1-2H3,(H,27,28,32) WSGKAAMBCWSOIA-UHFFFAOYSA-N 265942 US9718790, I-2058 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265942 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265942&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020001 377004814 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505505 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n(C2C[C@H]2C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 265943 US9718790, I-0674 P2X purinoceptor 3 Homo sapiens 126 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265943 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265943&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278197 377004815 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505506 Cc1ccc(Cn2c(=O)n(CCC(O)=O)c(=O)[nH]\c2=N/c2ccc(OC3CCC3)c(Cl)c2)cc1 InChI=1S/C24H25ClN4O5/c1-15-5-7-16(8-6-15)14-29-22(27-23(32)28(24(29)33)12-11-21(30)31)26-17-9-10-20(19(25)13-17)34-18-3-2-4-18/h5-10,13,18H,2-4,11-12,14H2,1H3,(H,30,31)(H,26,27,32) ZXMMRLAKSUQOAY-UHFFFAOYSA-N 265944 US9718790, I-1332 P2X purinoceptor 3 Homo sapiens 54.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265944 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265944&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278503 377004816 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505507 COC(=O)c1cccc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(C)c(=O)n2Cc2ccc(Cl)cc2)c1 InChI=1S/C25H21ClN4O5/c1-29-24(32)28-23(30(25(29)33)15-16-6-8-18(26)9-7-16)27-19-10-12-20(13-11-19)35-21-5-3-4-17(14-21)22(31)34-2/h3-14H,15H2,1-2H3,(H,27,28,32) BXYDXAYYFBAGEN-UHFFFAOYSA-N 265945 US9718790, I-2059 P2X purinoceptor 3 Homo sapiens 56.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265945 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265945&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945405 377004817 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505508 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n([C@H]2C[C@@H]2C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 265946 US9718790, I-0675 P2X purinoceptor 3 Homo sapiens 37.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265946 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265946&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945162 377004818 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505509 OC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(OC3CCC3)c(Cl)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H22Cl2N4O5/c24-15-6-4-14(5-7-15)13-29-21(27-22(32)28(23(29)33)11-10-20(30)31)26-16-8-9-19(18(25)12-16)34-17-2-1-3-17/h4-9,12,17H,1-3,10-11,13H2,(H,30,31)(H,26,27,32) GFFPNZREGNHRSF-UHFFFAOYSA-N 265947 US9718790, I-1333 P2X purinoceptor 3 Homo sapiens 52.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265947 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265947&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278332 377004819 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505510 Cc1ccc(Cn2c(=O)n(C)c(=O)[nH]\c2=N/c2ccc(Oc3cccc(c3)C(O)=O)cc2)cc1 InChI=1S/C25H22N4O5/c1-16-6-8-17(9-7-16)15-29-23(27-24(32)28(2)25(29)33)26-19-10-12-20(13-11-19)34-21-5-3-4-18(14-21)22(30)31/h3-14H,15H2,1-2H3,(H,30,31)(H,26,27,32) WCUUTJSKXJCCBP-UHFFFAOYSA-N 265948 US9718790, I-2060 P2X purinoceptor 3 Homo sapiens 22.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265948 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265948&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019858 377004820 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505511 COC(=O)C(C)(C)n1c(=O)[nH]\c(=N/c2ccc(O)c(Cl)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C21H20Cl2N4O5/c1-21(2,17(29)32-3)27-19(30)25-18(24-14-8-9-16(28)15(23)10-14)26(20(27)31)11-12-4-6-13(22)7-5-12/h4-10,28H,11H2,1-3H3,(H,24,25,30) LSYWXLXWLVXBKQ-UHFFFAOYSA-N 265949 US9718790, I-0676 P2X purinoceptor 3 Homo sapiens 30.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265949 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265949&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019621 377004821 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505512 CC(C)Oc1ccc(cc1Br)\N=c1/[nH]c(=O)n([C@@H](C)[C@@H](C)C(O)=O)c(=O)n1Cc1ccc(C)cc1 265950 US9718790, I-1334 P2X purinoceptor 3 Homo sapiens 11.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265950 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265950&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278241 377004822 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505513 Cc1ccc(Cn2c(=O)n(C)c(=O)[nH]\c2=N/c2ccc(Oc3ccc(cc3)C(O)=O)cc2)cc1 InChI=1S/C25H22N4O5/c1-16-3-5-17(6-4-16)15-29-23(27-24(32)28(2)25(29)33)26-19-9-13-21(14-10-19)34-20-11-7-18(8-12-20)22(30)31/h3-14H,15H2,1-2H3,(H,30,31)(H,26,27,32) LIIOOMDLKCFARB-UHFFFAOYSA-N 265951 US9718790, I-2061 P2X purinoceptor 3 Homo sapiens 148 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265951 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265951&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021131 377004823 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505514 COCc1ccc(cc1)\N=c1/[nH]c(=O)n(C[C@H](C)C(=O)OC)c(=O)n1Cc1ccc(Cl)cc1 265952 US9718790, I-0677 P2X purinoceptor 3 Homo sapiens 173 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265952 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265952&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019882 377004824 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505515 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2cccc(c2)C(F)(F)F)n(Cc2ccc(C)cc2)c1=O)C(O)=O 265953 US9718790, I-1335 P2X purinoceptor 3 Homo sapiens 30.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265953 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265953&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278504 377004825 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505516 Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(cc3)C(O)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H19ClN4O5/c1-28-23(32)27-22(29(24(28)33)14-15-2-6-17(25)7-3-15)26-18-8-12-20(13-9-18)34-19-10-4-16(5-11-19)21(30)31/h2-13H,14H2,1H3,(H,30,31)(H,26,27,32) YKMKZNKKHCLGTL-UHFFFAOYSA-N 265954 US9718790, I-2063 P2X purinoceptor 3 Homo sapiens 120 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265954 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265954&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278218 377004826 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505517 CCOc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(C[C@H](C)C(=O)OC)c(=O)n1Cc1ccc(C)cc1 265955 US9718790, I-0678 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265955 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265955&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019780 377004827 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505518 CC(C)Oc1ccc(cc1)\N=c1/[nH]c(=O)n([C@H](C)[C@H](C)C(O)=O)c(=O)n1Cc1ccc(C)cc1 265956 US9718790, I-1336 P2X purinoceptor 3 Homo sapiens 71.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265956 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265956&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278505 377004828 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505519 Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(c3)C(O)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H19ClN4O5/c1-28-23(32)27-22(29(24(28)33)14-15-5-7-17(25)8-6-15)26-18-9-11-19(12-10-18)34-20-4-2-3-16(13-20)21(30)31/h2-13H,14H2,1H3,(H,30,31)(H,26,27,32) JJRKVRMZBAICIJ-UHFFFAOYSA-N 265957 US9718790, I-2064 P2X purinoceptor 3 Homo sapiens 40.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265957 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265957&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278427 377004829 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505520 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n(Cc2ncn[nH]2)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C22H21ClFN7O3/c1-13(2)34-18-8-7-16(9-17(18)24)27-20-28-21(32)31(11-19-25-12-26-29-19)22(33)30(20)10-14-3-5-15(23)6-4-14/h3-9,12-13H,10-11H2,1-2H3,(H,25,26,29)(H,27,28,32) YSXNQXDUSQLVSZ-UHFFFAOYSA-N 265958 US9718790, I-0679 P2X purinoceptor 3 Homo sapiens 32.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265958 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265958&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019798 377004830 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505521 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n([C@H](C)[C@H](C)C(O)=O)c(=O)n1Cc1ccc(C)cc1 265959 US9718790, I-1337 P2X purinoceptor 3 Homo sapiens 14.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265959 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265959&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278247 377004831 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505522 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(CO)c3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H23ClN4O4/c1-2-29-24(32)28-23(30(25(29)33)15-17-6-8-19(26)9-7-17)27-20-10-12-21(13-11-20)34-22-5-3-4-18(14-22)16-31/h3-14,31H,2,15-16H2,1H3,(H,27,28,32) ZVRCBAFBQODEES-UHFFFAOYSA-N 265960 US9718790, I-2065 P2X purinoceptor 3 Homo sapiens 54.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265960 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265960&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021133 377004832 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505523 CC(C)Oc1ccc(cc1C)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(C)cc1 265961 US9718790, I-0680 P2X purinoceptor 3 Homo sapiens 26.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265961 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265961&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019800 377004833 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505524 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n([C@H](C)[C@H](C)C(O)=O)c(=O)n1Cc1ccc(C)cc1 265962 US9718790, I-1338 P2X purinoceptor 3 Homo sapiens 36.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265962 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265962&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945407 377004834 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505525 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(F)c(c3)C(O)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H20ClFN4O5/c1-2-30-24(34)29-23(31(25(30)35)14-15-3-5-16(26)6-4-15)28-17-7-9-18(10-8-17)36-19-11-12-21(27)20(13-19)22(32)33/h3-13H,2,14H2,1H3,(H,32,33)(H,28,29,34) HSLYDDOMIRFQDG-UHFFFAOYSA-N 265963 US9718790, I-2066 P2X purinoceptor 3 Homo sapiens 23.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265963 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265963&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021163 377004835 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505526 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc3oc(C)cc3c2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 265964 US9718790, I-0681 P2X purinoceptor 3 Homo sapiens 49.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265964 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265964&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020746 377004836 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505527 CC(C)Oc1ccc(cc1C)\N=c1/[nH]c(=O)n([C@H](C)[C@H](C)C(O)=O)c(=O)n1Cc1ccc(C)cc1 265965 US9718790, I-1339 P2X purinoceptor 3 Homo sapiens 30.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265965 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265965&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021086 377004837 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505528 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(n3)C(=O)OC)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H22ClN5O5/c1-3-30-24(33)29-23(31(25(30)34)15-16-7-9-17(26)10-8-16)27-18-11-13-19(14-12-18)36-21-6-4-5-20(28-21)22(32)35-2/h4-14H,3,15H2,1-2H3,(H,27,29,33) BWHFXSAJTHOAMZ-UHFFFAOYSA-N 265966 US9718790, I-2067 P2X purinoceptor 3 Homo sapiens 21.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265966 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265966&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021110 377004838 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505529 CCOc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(C)cc1 265967 US9718790, I-0682 P2X purinoceptor 3 Homo sapiens 23.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265967 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265967&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020757 377004839 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505530 CCCOc1ccc(cc1)\N=c1/[nH]c(=O)n([C@H](C)[C@H](C)C(O)=O)c(=O)n1Cc1ccc(C)cc1 265968 US9718790, I-1340 P2X purinoceptor 3 Homo sapiens 57.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265968 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265968&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945112 377004840 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505531 CCOC(=O)OC(=O)c1ccc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(CC)c(=O)n2Cc2ccc(C)cc2)cc1 InChI=1S/C29H28N4O7/c1-4-32-27(35)31-26(33(28(32)36)18-20-8-6-19(3)7-9-20)30-22-12-16-24(17-13-22)39-23-14-10-21(11-15-23)25(34)40-29(37)38-5-2/h6-17H,4-5,18H2,1-3H3,(H,30,31,35) CIOZRZIWIOXRAT-UHFFFAOYSA-N 265969 US9718790, I-2068 P2X purinoceptor 3 Homo sapiens 16.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265969 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265969&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945634 377004841 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504864 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(CC3CCCC3)cc2)n(Cc2ccc(Cl)cc2)c1=O 265312 US9718790, I-1097 P2X purinoceptor 3 Homo sapiens 141 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265312 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265312&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019574 377004187 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504865 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc3oc(nc3c2)-c2ccncc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 265313 US9718790, I-1816 P2X purinoceptor 3 Homo sapiens 300 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265313 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265313&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278293 377004188 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504866 CNC(=O)Cn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(Cl)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C22H23Cl2N5O4/c1-13(2)33-18-9-8-16(10-17(18)24)26-20-27-21(31)29(12-19(30)25-3)22(32)28(20)11-14-4-6-15(23)7-5-14/h4-10,13H,11-12H2,1-3H3,(H,25,30)(H,26,27,31) MECLRPZHYAVFCN-UHFFFAOYSA-N 183268 US9150546, I-436::US9688643, I-436::US9718790, I-0445 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183268 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183268&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020149 313634668 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504867 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(C=C3CCCC3)cc2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 265315 US9718790, I-1098 P2X purinoceptor 3 Homo sapiens 74.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265315 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265315&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019603 377004190 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504868 CCCc1cc2cc(ccc2o1)\N=c1/[nH]c(=O)n([C@@H](C)[C@@H](C)C(=O)OC)c(=O)n1Cc1ccc(Cl)cc1 265316 US9718790, I-1817 P2X purinoceptor 3 Homo sapiens 52.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265316 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265316&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278559 377004191 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504869 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(CC(=O)NCCO)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C23H25Cl2N5O5/c1-14(2)35-19-8-7-17(11-18(19)25)27-21-28-22(33)30(13-20(32)26-9-10-31)23(34)29(21)12-15-3-5-16(24)6-4-15/h3-8,11,14,31H,9-10,12-13H2,1-2H3,(H,26,32)(H,27,28,33) BIYJLHSGOGOXOH-UHFFFAOYSA-N 183269 US9150546, I-437::US9688643, I-437::US9718790, I-0446 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183269 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183269&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020741 313634669 C04080 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504870 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(C=C3CCCC3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 265318 US9718790, I-1099 P2X purinoceptor 3 Homo sapiens 70.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265318 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265318&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019720 377004193 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504871 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc3[nH]c(=O)[nH]c(=O)c3c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 265319 US9718790, I-1818 P2X purinoceptor 3 Homo sapiens 829 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265319 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265319&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 135121003 377004194 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504872 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(CC(=O)NCC(N)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C23H24Cl2N6O5/c1-13(2)36-18-8-7-16(9-17(18)25)28-21-29-22(34)31(12-20(33)27-10-19(26)32)23(35)30(21)11-14-3-5-15(24)6-4-14/h3-9,13H,10-12H2,1-2H3,(H2,26,32)(H,27,33)(H,28,29,34) PYMAUQBCJZWXQE-UHFFFAOYSA-N 183270 US9150546, I-438::US9688643, I-438::US9718790, I-0447 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183270 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183270&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020742 313634670 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504873 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(CC3CCCC3)cc2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 265321 US9718790, I-1100 P2X purinoceptor 3 Homo sapiens 43.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265321 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265321&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019689 377004196 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504874 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc3NC(=O)CCc3c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 265322 US9718790, I-1819 P2X purinoceptor 3 Homo sapiens 873 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265322 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265322&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130279122 377004197 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504875 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n(CCC(=O)NCC#N)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C24H24ClFN6O4/c1-15(2)36-20-8-7-18(13-19(20)26)29-22-30-23(34)31(12-9-21(33)28-11-10-27)24(35)32(22)14-16-3-5-17(25)6-4-16/h3-8,13,15H,9,11-12,14H2,1-2H3,(H,28,33)(H,29,30,34) KKWDEJBVLDOLBA-UHFFFAOYSA-N 183271 US9150546, I-439::US9688643, I-439::US9718790, I-0448 P2X purinoceptor 3 Homo sapiens 18.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183271 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183271&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578770 313634671 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504876 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(CC3CCCC3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 265324 US9718790, I-1101 P2X purinoceptor 3 Homo sapiens 53.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265324 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265324&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021018 377004199 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504877 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc3OCCCc3c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 265325 US9718790, I-1820 P2X purinoceptor 3 Homo sapiens 204 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265325 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265325&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020515 377004200 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504878 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n(CCC(=O)NCC(N)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C24H26ClFN6O5/c1-14(2)37-19-8-7-17(11-18(19)26)29-22-30-23(35)31(10-9-21(34)28-12-20(27)33)24(36)32(22)13-15-3-5-16(25)6-4-15/h3-8,11,14H,9-10,12-13H2,1-2H3,(H2,27,33)(H,28,34)(H,29,30,35) RGZKSIUPCLTSCH-UHFFFAOYSA-N 183272 US9150546, I-440::US9688643, I-440::US9718790, I-0449 P2X purinoceptor 3 Homo sapiens 55.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183272 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183272&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578555 313634672 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504879 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc3OCCCc3c2)n(Cc2ccc(Cl)cc2)c1=O 265327 US9718790, I-1102 P2X purinoceptor 3 Homo sapiens 148 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265327 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265327&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021056 377004202 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504880 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc3OC(F)(F)Oc3c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 265328 US9718790, I-1821 P2X purinoceptor 3 Homo sapiens 429 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265328 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265328&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945306 377004203 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504881 CCOc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(CC(C)(C)C(=O)OC)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C24H26Cl2N4O5/c1-5-35-19-11-10-17(12-18(19)26)27-21-28-22(32)30(14-24(2,3)20(31)34-4)23(33)29(21)13-15-6-8-16(25)9-7-15/h6-12H,5,13-14H2,1-4H3,(H,27,28,32) DWLNSOSNBWRGBL-UHFFFAOYSA-N 183273 US9150546, I-441::US9688643, I-441::US9718790, I-0450 P2X purinoceptor 3 Homo sapiens 11.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183273 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183273&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578550 313634673 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504882 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc3OCCCc3c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 265330 US9718790, I-1103 P2X purinoceptor 3 Homo sapiens 423 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265330 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265330&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021042 377004205 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504883 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc3[nH]c(S)nc3c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O InChI=1S/C22H19ClN6O4S/c1-11(18(30)31)12(2)29-21(32)27-19(24-15-7-8-16-17(9-15)26-20(34)25-16)28(22(29)33)10-13-3-5-14(23)6-4-13/h3-9,11-12H,10H2,1-2H3,(H,26,34)(H,30,31)/b24-15+/t11-,12+/m1/s1 LFIMDYVEMZTOAJ-NVZGOQJLSA-N 265331 US9718790, I-1822 P2X purinoceptor 3 Homo sapiens 332 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265331 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265331&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020248 377004206 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504884 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(OC)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H27ClN4O5/c1-15-12-18(10-11-19(15)33-4)26-21-27-22(31)29(14-24(2,3)20(30)34-5)23(32)28(21)13-16-6-8-17(25)9-7-16/h6-12H,13-14H2,1-5H3,(H,26,27,31) XOWYLKBNXGGNSB-UHFFFAOYSA-N 183274 US9150546, I-442::US9688643, I-442::US9718790, I-0451 P2X purinoceptor 3 Homo sapiens 117 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183274 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183274&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578703 313634674 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504885 COC(=O)[C@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)cc2)n(Cc2ccc(C)cc2)c1=O 265333 US9718790, I-1104 P2X purinoceptor 3 Homo sapiens 11.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265333 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265333&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945274 377004208 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504886 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc3c(O)cccc3c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 265334 US9718790, I-1826 P2X purinoceptor 3 Homo sapiens 751 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265334 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265334&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020171 377004209 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504887 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2cccc(OC(F)F)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H23ClF2N4O5/c1-23(2,18(31)34-3)13-30-21(32)28-20(27-16-5-4-6-17(11-16)35-19(25)26)29(22(30)33)12-14-7-9-15(24)10-8-14/h4-11,19H,12-13H2,1-3H3,(H,27,28,32) HFCDVAYEMKHXOT-UHFFFAOYSA-N 183275 US9150546, I-443::US9688643, I-443::US9718790, I-0452 P2X purinoceptor 3 Homo sapiens 207 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183275 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183275&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578778 313634675 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504888 CC(C)Oc1ccc(cc1)\N=c1/[nH]c(=O)n(C[C@@H](C)C(O)=O)c(=O)n1Cc1ccc(C)cc1 265336 US9718790, I-1105 P2X purinoceptor 3 Homo sapiens 152 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265336 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265336&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945355 377004211 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504889 COC(=O)[C@H](C)[C@H](C)n1c(=O)[nH]\c(=N/c2ccc3oc4ccccc4c3c2)n(Cc2ccc(Cl)cc2)c1=O 265337 US9718790, I-1827 P2X purinoceptor 3 Homo sapiens 913 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265337 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265337&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278208 377004212 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504890 COC(=O)c1ccc(Cn2c(=O)[nH]\c(=N/c3ccc(OC(C)C)c(F)c3)n(Cc3ccc(Cl)cc3)c2=O)cc1 InChI=1S/C28H26ClFN4O5/c1-17(2)39-24-13-12-22(14-23(24)30)31-26-32-27(36)34(16-18-4-8-20(9-5-18)25(35)38-3)28(37)33(26)15-19-6-10-21(29)11-7-19/h4-14,17H,15-16H2,1-3H3,(H,31,32,36) ZHMRJAFBBUPXMN-UHFFFAOYSA-N 183276 US9150546, I-444::US9688643, I-444::US9718790, I-0453 P2X purinoceptor 3 Homo sapiens 17.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183276 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183276&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578403 313634676 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504891 CCOc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(C[C@@H](C)C(=O)OC)c(=O)n1Cc1ccc(C)cc1 265339 US9718790, I-1106 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265339 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265339&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019600 377004214 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504892 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc3nc(sc3c2)-c2ccccc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 265340 US9718790, I-1829 P2X purinoceptor 3 Homo sapiens 92.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265340 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265340&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020286 377004215 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504893 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n(Cc2ccc(cc2)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C27H24ClFN4O5/c1-16(2)38-23-12-11-21(13-22(23)29)30-25-31-26(36)33(15-17-3-7-19(8-4-17)24(34)35)27(37)32(25)14-18-5-9-20(28)10-6-18/h3-13,16H,14-15H2,1-2H3,(H,34,35)(H,30,31,36) DNJOLFSVJHMOER-UHFFFAOYSA-N 183277 US9150546, I-445::US9688643, I-445::US9718790, I-0454 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183277 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183277&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578446 313634677 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504894 CCOc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(C[C@@H](C)C(O)=O)c(=O)n1Cc1ccc(C)cc1 265342 US9718790, I-1107 P2X purinoceptor 3 Homo sapiens 43.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265342 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265342&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945270 377004217 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504895 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc3C(=O)CCc3c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 265343 US9718790, I-1830 P2X purinoceptor 3 Homo sapiens 869 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265343 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265343&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020250 377004218 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504896 CCOc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C23H24Cl2N4O5/c1-4-34-18-10-9-16(11-17(18)25)26-20-27-21(32)29(13-23(2,3)19(30)31)22(33)28(20)12-14-5-7-15(24)8-6-14/h5-11H,4,12-13H2,1-3H3,(H,30,31)(H,26,27,32) PYUFNUBNBBFONC-UHFFFAOYSA-N 183278 US9150546, I-446::US9688643, I-446::US9718790, I-0455 P2X purinoceptor 3 Homo sapiens 20.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183278 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183278&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578767 313634678 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504897 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(cc2)C2CCCCC2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 265345 US9718790, I-1108 P2X purinoceptor 3 Homo sapiens 50.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265345 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265345&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019659 377004220 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504898 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc3CCC(=O)c3c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 265346 US9718790, I-1831 P2X purinoceptor 3 Homo sapiens 739 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265346 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265346&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020301 377004221 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504899 COc1ccc(cc1C)\N=c1/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C23H25ClN4O5/c1-14-11-17(9-10-18(14)33-4)25-20-26-21(31)28(13-23(2,3)19(29)30)22(32)27(20)12-15-5-7-16(24)8-6-15/h5-11H,12-13H2,1-4H3,(H,29,30)(H,25,26,31) NWLNPCNCHXEXRK-UHFFFAOYSA-N 183279 US9150546, I-447::US9688643, I-447::US9718790, I-0456 P2X purinoceptor 3 Homo sapiens 279 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183279 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183279&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578879 313634679 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504900 C[C@@H](Cn1c(=O)[nH]\c(=N/c2cccc(c2)C2CCCCC2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 265348 US9718790, I-1109 P2X purinoceptor 3 Homo sapiens 430 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265348 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265348&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945276 377004223 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504901 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc3cc(Br)ccc3c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 265349 US9718790, I-1832 P2X purinoceptor 3 Homo sapiens 32.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265349 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265349&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945254 377004224 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504902 CC(C)(Cn1c(=O)[nH]\c(=N/c2cccc(OC(F)F)c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O InChI=1S/C22H21ClF2N4O5/c1-22(2,17(30)31)12-29-20(32)27-19(26-15-4-3-5-16(10-15)34-18(24)25)28(21(29)33)11-13-6-8-14(23)9-7-13/h3-10,18H,11-12H2,1-2H3,(H,30,31)(H,26,27,32) OUDZDPSOGUVUGK-UHFFFAOYSA-N 183280 US9150546, I-448::US9688643, I-448::US9718790, I-0457 P2X purinoceptor 3 Homo sapiens 388 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183280 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183280&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578657 313634680 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504903 C[C@@H](Cn1c(=O)[nH]\c(=N/c2cccc(c2)C2CCCC2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 265351 US9718790, I-1110 P2X purinoceptor 3 Homo sapiens 397 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265351 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265351&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019573 377004226 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504904 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc3OCCc3c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 265352 US9718790, I-1833 P2X purinoceptor 3 Homo sapiens 580 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265352 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265352&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020173 377004227 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504905 COC(=O)c1cccc(Cn2c(=O)[nH]\c(=N/c3ccc(OC(C)C)c(F)c3)n(Cc3ccc(Cl)cc3)c2=O)c1 InChI=1S/C28H26ClFN4O5/c1-17(2)39-24-12-11-22(14-23(24)30)31-26-32-27(36)34(16-19-5-4-6-20(13-19)25(35)38-3)28(37)33(26)15-18-7-9-21(29)10-8-18/h4-14,17H,15-16H2,1-3H3,(H,31,32,36) HLAKNNMHJAMFON-UHFFFAOYSA-N 183281 US9150546, I-450::US9688643, I-450::US9718790, I-0459 P2X purinoceptor 3 Homo sapiens 36.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183281 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183281&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578760 313634681 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504906 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(cc2)C2=CCCCC2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 265354 US9718790, I-1111 P2X purinoceptor 3 Homo sapiens 161 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265354 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265354&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020819 377004229 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504907 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc3ncccc3c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 265355 US9718790, I-1834 P2X purinoceptor 3 Homo sapiens 325 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265355 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265355&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945644 377004230 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504908 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n(Cc2cccc(c2)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C27H24ClFN4O5/c1-16(2)38-23-11-10-21(13-22(23)29)30-25-31-26(36)33(15-18-4-3-5-19(12-18)24(34)35)27(37)32(25)14-17-6-8-20(28)9-7-17/h3-13,16H,14-15H2,1-2H3,(H,34,35)(H,30,31,36) KRVHHMRULNJILW-UHFFFAOYSA-N 183282 US9150546, I-451::US9688643, I-451::US9718790, I-0460 P2X purinoceptor 3 Homo sapiens 16.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183282 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183282&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578505 313634682 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504909 C[C@@H](Cn1c(=O)[nH]\c(=N/c2cccc(c2)C2=CCCCC2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 265357 US9718790, I-1112 P2X purinoceptor 3 Homo sapiens 872 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265357 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265357&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020821 377004232 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504910 Cc1cc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(CCCO)c(=O)n2Cc2ccc(Cl)cc2)no1 InChI=1S/C23H22ClN5O5/c1-15-13-20(27-34-15)33-19-9-7-18(8-10-19)25-21-26-22(31)28(11-2-12-30)23(32)29(21)14-16-3-5-17(24)6-4-16/h3-10,13,30H,2,11-12,14H2,1H3,(H,25,26,31) JBYFTLZHUFBJCW-UHFFFAOYSA-N 265358 US9718790, I-1835 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265358 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265358&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020179 377004233 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504911 COC(=O)[C@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O 183283 US9150546, I-452::US9688643, I-452::US9718790, I-0461 P2X purinoceptor 3 Homo sapiens 3.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183283 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183283&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578451 313634683 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504913 COC(=O)CCn1c(=O)[nH]\c(=N/c2cc(C(=O)OC)n(C)c2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C22H25N5O6/c1-14-5-7-15(8-6-14)12-27-20(23-16-11-17(19(29)33-4)25(2)13-16)24-21(30)26(22(27)31)10-9-18(28)32-3/h5-8,11,13H,9-10,12H2,1-4H3,(H,23,24,30) UHHDDRHAASSAHL-UHFFFAOYSA-N 265360 US9718790, I-1836 P2X purinoceptor 3 Homo sapiens 787 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265360 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265360&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020608 377004235 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504914 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O 183284 US9150546, I-453::US9688643, I-453::US9718790, I-0462 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183284 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183284&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578468 313634684 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504915 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(cc2)C2=CCCC2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 265362 US9718790, I-1114 P2X purinoceptor 3 Homo sapiens 214 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265362 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265362&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020823 377004237 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504916 CC(C)NC(=O)c1nn(C)cc1\N=c1/[nH]c(=O)n(CCC(O)=O)c(=O)n1Cc1ccc(C)cc1 InChI=1S/C22H27N7O5/c1-13(2)23-19(32)18-16(12-27(4)26-18)24-20-25-21(33)28(10-9-17(30)31)22(34)29(20)11-15-7-5-14(3)6-8-15/h5-8,12-13H,9-11H2,1-4H3,(H,23,32)(H,30,31)(H,24,25,33) VMEIFSWFMASBEL-UHFFFAOYSA-N 265363 US9718790, I-1839 P2X purinoceptor 3 Homo sapiens 107 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265363 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265363&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020612 377004238 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504917 CCOC(=O)c1ccccc1Cn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C29H28ClFN4O5/c1-4-39-26(36)23-8-6-5-7-20(23)17-35-28(37)33-27(32-22-13-14-25(24(31)15-22)40-18(2)3)34(29(35)38)16-19-9-11-21(30)12-10-19/h5-15,18H,4,16-17H2,1-3H3,(H,32,33,37) OBBYQKMKICRPKD-UHFFFAOYSA-N 183285 US9150546, I-454::US9688643, I-454::US9718790, I-0463 P2X purinoceptor 3 Homo sapiens 24.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183285 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183285&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578850 313634685 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504918 C[C@@H](Cn1c(=O)[nH]\c(=N/c2cccc(c2)C2=CCCC2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 265365 US9718790, I-1115 P2X purinoceptor 3 Homo sapiens 516 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265365 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265365&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020824 377004240 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504919 CCc1oc2ccc(cc2c1C)\N=c1/[nH]c(=O)n(CC2COC(C)(C)OC2)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C28H31ClN4O5/c1-5-23-17(2)22-12-21(10-11-24(22)38-23)30-25-31-26(34)33(14-19-15-36-28(3,4)37-16-19)27(35)32(25)13-18-6-8-20(29)9-7-18/h6-12,19H,5,13-16H2,1-4H3,(H,30,31,34) PZLPJTFPYOYHKF-UHFFFAOYSA-N 265366 US9718790, I-1840 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265366 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265366&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945559 377004241 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504920 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n(C[C@@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 183286 US9150546, I-455::US9688643, I-455::US9718790, I-0464 P2X purinoceptor 3 Homo sapiens 30.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183286 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183286&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578375 313634686 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504921 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(OC3CCOCC3)nc2)n(Cc2ccc(C)cc2)c1=O 265368 US9718790, I-1118 P2X purinoceptor 3 Homo sapiens 387 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265368 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265368&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020834 377004243 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504922 CC1(C)OCC(Cn2c(=O)[nH]\c(=N/c3ccc(OCC4CC4)cc3)n(Cc3ccc(Cl)cc3)c2=O)CO1 InChI=1S/C27H31ClN4O5/c1-27(2)36-16-20(17-37-27)14-32-25(33)30-24(31(26(32)34)13-18-5-7-21(28)8-6-18)29-22-9-11-23(12-10-22)35-15-19-3-4-19/h5-12,19-20H,3-4,13-17H2,1-2H3,(H,29,30,33) XXNBZUOJKOBAAN-UHFFFAOYSA-N 265369 US9718790, I-1841 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265369 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265369&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019974 377004244 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504923 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 183287 US9150546, I-456::US9688643, I-456::US9718790, I-0465 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183287 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183287&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578933 313634687 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504924 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(OC3CCOCC3)nc2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 265371 US9718790, I-1120 P2X purinoceptor 3 Homo sapiens 534 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265371 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265371&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020845 377004246 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504925 CCc1oc2ccc(cc2c1C)\N=c1/[nH]c(=O)n(CC(CO)CO)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C25H27ClN4O5/c1-3-21-15(2)20-10-19(8-9-22(20)35-21)27-23-28-24(33)30(12-17(13-31)14-32)25(34)29(23)11-16-4-6-18(26)7-5-16/h4-10,17,31-32H,3,11-14H2,1-2H3,(H,27,28,33) QBTDKEYOKKTTJP-UHFFFAOYSA-N 265372 US9718790, I-1842 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265372 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265372&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019851 377004247 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504926 COC(=O)[C@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(Cl)c2)n(Cc2ccc(Cl)cc2)c1=O 183288 US9150546, I-457::US9688643, I-457::US9718790, I-0466 P2X purinoceptor 3 Homo sapiens 3.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183288 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183288&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578609 313634688 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504927 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccncc3)cc2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 265374 US9718790, I-1122 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265374 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265374&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945365 377004249 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504928 COc1ccc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(CC(CO)CO)c(=O)n2Cc2ccc(Cl)cc2)cn1 InChI=1S/C26H26ClN5O6/c1-37-23-11-10-22(12-28-23)38-21-8-6-20(7-9-21)29-24-30-25(35)32(14-18(15-33)16-34)26(36)31(24)13-17-2-4-19(27)5-3-17/h2-12,18,33-34H,13-16H2,1H3,(H,29,30,35) LPMBQYSVTOTDDJ-UHFFFAOYSA-N 265375 US9718790, I-1843 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265375 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265375&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278379 377004250 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504929 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(Cl)c2)n(Cc2ccc(Cl)cc2)c1=O 183289 US9150546, I-458::US9688643, I-458::US9718790, I-0467 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183289 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183289&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578838 313634689 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504930 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cccnc3)cc2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 265377 US9718790, I-1123 P2X purinoceptor 3 Homo sapiens 14.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265377 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265377&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945132 377004252 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505360 COc1cc(ccc1OC(C)C)\N=c1/[nH]c(=O)n(CCO)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C22H25ClN4O5/c1-14(2)32-18-9-8-17(12-19(18)31-3)24-20-25-21(29)26(10-11-28)22(30)27(20)13-15-4-6-16(23)7-5-15/h4-9,12,14,28H,10-11,13H2,1-3H3,(H,24,25,29) GROXCDJMGGBYBM-UHFFFAOYSA-N 265798 US9718790, I-2006 P2X purinoceptor 3 Homo sapiens 36.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265798 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265798&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020575 377004670 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505361 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(C)c2)n(Cc2ccc(F)cc2)c1=O 265799 US9718790, I-0625 P2X purinoceptor 3 Homo sapiens 66.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265799 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265799&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278159 377004671 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505362 CCCc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(C[C@H](C)C(=O)OC)c(=O)n1Cc1ccc(C)cc1 265800 US9718790, I-1277 P2X purinoceptor 3 Homo sapiens 15.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265800 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265800&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278321 377004672 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505363 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(CCC(O)=O)c(=O)n1CC1CCC(C)CC1 InChI=1S/C23H31ClN4O5/c1-14(2)33-19-9-8-17(12-18(19)24)25-21-26-22(31)27(11-10-20(29)30)23(32)28(21)13-16-6-4-15(3)5-7-16/h8-9,12,14-16H,4-7,10-11,13H2,1-3H3,(H,29,30)(H,25,26,31) MRLFSNZMTSBHPL-UHFFFAOYSA-N 265801 US9718790, I-2007 P2X purinoceptor 3 Homo sapiens 17.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265801 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265801&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020529 377004673 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505364 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(Cl)c2)n(Cc2ccc(F)cc2)c1=O 265802 US9718790, I-0626 P2X purinoceptor 3 Homo sapiens 22.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265802 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265802&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278456 377004674 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505365 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc3nc(C)ccc3c2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 265803 US9718790, I-1278 P2X purinoceptor 3 Homo sapiens 33.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265803 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265803&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019650 377004675 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505366 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccnc(OC)n3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H21ClN6O4/c1-3-29-22(31)28-20(30(23(29)32)14-15-4-6-16(24)7-5-15)26-17-8-10-18(11-9-17)34-19-12-13-25-21(27-19)33-2/h4-13H,3,14H2,1-2H3,(H,26,28,31) NWSTYJIUQBPBQL-UHFFFAOYSA-N 265804 US9718790, I-2008 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265804 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265804&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020531 377004676 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505367 CCCc1ccc(cc1)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 265805 US9718790, I-0627 P2X purinoceptor 3 Homo sapiens 91.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265805 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265805&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278457 377004677 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505368 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc3nc(C)oc3c2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 265806 US9718790, I-1279 P2X purinoceptor 3 Homo sapiens 158 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265806 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265806&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019578 377004678 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505369 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccc3C(N)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H22ClN5O4/c1-2-30-24(33)29-23(31(25(30)34)15-16-7-9-17(26)10-8-16)28-18-11-13-19(14-12-18)35-21-6-4-3-5-20(21)22(27)32/h3-14H,2,15H2,1H3,(H2,27,32)(H,28,29,33) ZKSMPELQSOTWAN-UHFFFAOYSA-N 265807 US9718790, I-2009 P2X purinoceptor 3 Homo sapiens 472 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265807 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265807&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020543 377004679 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505370 C[C@@H](Cn1c(=O)[nH]\c(=N/c2cccc(c2)C(F)(F)F)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 265808 US9718790, I-0628 P2X purinoceptor 3 Homo sapiens 61.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265808 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265808&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278491 377004680 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505371 COc1cc(ccc1OC(C)C)\N=c1/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n1Cc1ccc(C)cc1 InChI=1S/C26H32N4O6/c1-16(2)36-20-12-11-19(13-21(20)35-6)27-23-28-24(33)30(15-26(4,5)22(31)32)25(34)29(23)14-18-9-7-17(3)8-10-18/h7-13,16H,14-15H2,1-6H3,(H,31,32)(H,27,28,33) CGXLOPGVIUHXHN-UHFFFAOYSA-N 265809 US9718790, I-1280 P2X purinoceptor 3 Homo sapiens 27.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265809 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265809&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945386 377004681 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505372 OCCn1c(=O)[nH]\c(=N/c2ccc(OC3CCC3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C22H23ClN4O4/c23-16-6-4-15(5-7-16)14-27-20(25-21(29)26(12-13-28)22(27)30)24-17-8-10-19(11-9-17)31-18-2-1-3-18/h4-11,18,28H,1-3,12-14H2,(H,24,25,29) XOVGHRVUQVUXGP-UHFFFAOYSA-N 265810 US9718790, I-2010 P2X purinoceptor 3 Homo sapiens 54.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265810 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265810&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020533 377004682 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505373 CC(C)Oc1ccc(cc1C)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(F)cc1 265811 US9718790, I-0629 P2X purinoceptor 3 Homo sapiens 127 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265811 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265811&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278458 377004683 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505374 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(OC3CCC3)cc2)n(Cc2ccc(Cl)cc2)c1=O 265812 US9718790, I-1281 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265812 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265812&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020243 377004684 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505375 CNC(=O)c1cc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(C)c(=O)n2Cc2ccc(Cl)cc2)ccn1 InChI=1S/C24H21ClN6O4/c1-26-21(32)20-13-19(11-12-27-20)35-18-9-7-17(8-10-18)28-22-29-23(33)30(2)24(34)31(22)14-15-3-5-16(25)6-4-15/h3-13H,14H2,1-2H3,(H,26,32)(H,28,29,33) RHCBIKYFCCVCNL-UHFFFAOYSA-N 265813 US9718790, I-2011 P2X purinoceptor 3 Homo sapiens 10.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265813 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265813&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278422 377004685 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505376 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(F)cc1 265814 US9718790, I-0630 P2X purinoceptor 3 Homo sapiens 30.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265814 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265814&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278160 377004686 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505377 CCOC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(OC3CCC3)cc2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C26H30N4O5/c1-3-34-23(31)15-16-29-25(32)28-24(30(26(29)33)17-19-9-7-18(2)8-10-19)27-20-11-13-22(14-12-20)35-21-5-4-6-21/h7-14,21H,3-6,15-17H2,1-2H3,(H,27,28,32) HZSHQXRGCOPXII-UHFFFAOYSA-N 265815 US9718790, I-1282 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265815 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265815&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 89666973 377004687 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505378 CNC(=O)c1cc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(C)c(=O)n2Cc2ccc(C)cc2)ccn1 InChI=1S/C25H24N6O4/c1-16-4-6-17(7-5-16)15-31-23(29-24(33)30(3)25(31)34)28-18-8-10-19(11-9-18)35-20-12-13-27-21(14-20)22(32)26-2/h4-14H,15H2,1-3H3,(H,26,32)(H,28,29,33) BRXUBQQJBHBOKQ-UHFFFAOYSA-N 265816 US9718790, I-2012 P2X purinoceptor 3 Homo sapiens 9.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265816 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265816&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021041 377004688 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505379 COC(=O)[C@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(C)c2)n(CC2CCCCC2)c1=O 265817 US9718790, I-0631 P2X purinoceptor 3 Homo sapiens 10.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265817 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265817&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945038 377004689 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505380 CCOC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(OC3CCC3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H27ClN4O5/c1-2-34-22(31)14-15-29-24(32)28-23(30(25(29)33)16-17-6-8-18(26)9-7-17)27-19-10-12-21(13-11-19)35-20-4-3-5-20/h6-13,20H,2-5,14-16H2,1H3,(H,27,28,32) PBEDONMWBOPMOR-UHFFFAOYSA-N 265818 US9718790, I-1283 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265818 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265818&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 89636631 377004690 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505381 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccnc(c3)C(=O)NC)cc2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C26H26N6O4/c1-4-31-25(34)30-24(32(26(31)35)16-18-7-5-17(2)6-8-18)29-19-9-11-20(12-10-19)36-21-13-14-28-22(15-21)23(33)27-3/h5-15H,4,16H2,1-3H3,(H,27,33)(H,29,30,34) NWANDJDOQHSXMR-UHFFFAOYSA-N 265819 US9718790, I-2013 P2X purinoceptor 3 Homo sapiens 3.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265819 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265819&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020992 377004691 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505382 CCOc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(C[C@@H](C)C(=O)OC)c(=O)n1CC1CCCCC1 265820 US9718790, I-0632 P2X purinoceptor 3 Homo sapiens 11.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265820 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265820&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118944999 377004692 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505383 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(OC3CCC3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 265821 US9718790, I-1284 P2X purinoceptor 3 Homo sapiens 15.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265821 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265821&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945151 377004693 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505384 CCOC(=O)C1(COc2ccc(cc2)\N=c2/[nH]c(=O)n(CC)c(=O)n2Cc2ccc(Cl)cc2)CC1 InChI=1S/C25H27ClN4O5/c1-3-29-23(32)28-22(30(24(29)33)15-17-5-7-18(26)8-6-17)27-19-9-11-20(12-10-19)35-16-25(13-14-25)21(31)34-4-2/h5-12H,3-4,13-16H2,1-2H3,(H,27,28,32) AZAKLNFKPBUVQG-UHFFFAOYSA-N 265822 US9718790, I-2014 P2X purinoceptor 3 Homo sapiens 360 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265822 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265822&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021045 377004694 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505385 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(C[C@H]2COC(C)(C)O2)c(=O)n1Cc1ccc(Cl)cc1 265823 US9718790, I-0633 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265823 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265823&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020104 377004695 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505386 Cc1ccc(Cn2c(=O)n(CCC(O)=O)c(=O)[nH]\c2=N/c2ccc(OC3CCC3)cc2)cc1 InChI=1S/C24H26N4O5/c1-16-5-7-17(8-6-16)15-28-22(26-23(31)27(24(28)32)14-13-21(29)30)25-18-9-11-20(12-10-18)33-19-3-2-4-19/h5-12,19H,2-4,13-15H2,1H3,(H,29,30)(H,25,26,31) OLOSQNCONXESQI-UHFFFAOYSA-N 265824 US9718790, I-1285 P2X purinoceptor 3 Homo sapiens 51.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265824 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265824&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278326 377004696 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505387 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(C)c(c3)C(=O)OC)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C27H25ClN4O5/c1-4-31-26(34)30-25(32(27(31)35)16-18-6-8-19(28)9-7-18)29-20-10-13-21(14-11-20)37-22-12-5-17(2)23(15-22)24(33)36-3/h5-15H,4,16H2,1-3H3,(H,29,30,34) DTAPDFAISHLNRJ-UHFFFAOYSA-N 265825 US9718790, I-2015 P2X purinoceptor 3 Homo sapiens 32.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265825 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265825&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021013 377004697 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505388 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n(CCCNC(N)=N)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C23H27ClFN7O3/c1-14(2)35-19-9-8-17(12-18(19)25)29-21-30-22(33)31(11-3-10-28-20(26)27)23(34)32(21)13-15-4-6-16(24)7-5-15/h4-9,12,14H,3,10-11,13H2,1-2H3,(H4,26,27,28)(H,29,30,33) OJYACZXEXOBMRO-UHFFFAOYSA-N 265826 US9718790, I-0634 P2X purinoceptor 3 Homo sapiens 11.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265826 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265826&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020136 377004698 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505389 OC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(OC3CCC3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H23ClN4O5/c24-16-6-4-15(5-7-16)14-28-21(26-22(31)27(23(28)32)13-12-20(29)30)25-17-8-10-19(11-9-17)33-18-2-1-3-18/h4-11,18H,1-3,12-14H2,(H,29,30)(H,25,26,31) AEXHDKVJWWGLSS-UHFFFAOYSA-N 265827 US9718790, I-1286 P2X purinoceptor 3 Homo sapiens 34.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265827 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265827&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020205 377004699 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505390 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccnc(O)n3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C22H19ClN6O4/c1-2-28-21(31)27-19(29(22(28)32)13-14-3-5-15(23)6-4-14)25-16-7-9-17(10-8-16)33-18-11-12-24-20(30)26-18/h3-12H,2,13H2,1H3,(H,24,26,30)(H,25,27,31) IVEBHNLMDWSFLG-UHFFFAOYSA-N 265828 US9718790, I-2016 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265828 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265828&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945392 377004700 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505391 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n(CC(=O)NN)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C21H22ClFN6O4/c1-12(2)33-17-8-7-15(9-16(17)23)25-19-26-20(31)29(11-18(30)27-24)21(32)28(19)10-13-3-5-14(22)6-4-13/h3-9,12H,10-11,24H2,1-2H3,(H,27,30)(H,25,26,31) MSXUEXYLHXHJEN-UHFFFAOYSA-N 265829 US9718790, I-0635 P2X purinoceptor 3 Homo sapiens 19.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265829 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265829&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020105 377004701 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505392 CC(C)n1c(=O)n(Cc2ccc(Cl)cc2)c(=O)n(Cc2ccc(cc2)C(F)(F)F)c1=O InChI=1S/C21H19ClF3N3O3/c1-13(2)28-19(30)26(11-14-3-7-16(8-4-14)21(23,24)25)18(29)27(20(28)31)12-15-5-9-17(22)10-6-15/h3-10,13H,11-12H2,1-2H3 LUGSKCGBDOVFNF-UHFFFAOYSA-N 265830 US9718790, I-1289 P2X purinoceptor 3 Homo sapiens 510 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265830 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265830&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019495 377004702 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505393 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(C)c(c3)C(O)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H23ClN4O5/c1-3-30-25(34)29-24(31(26(30)35)15-17-5-7-18(27)8-6-17)28-19-9-12-20(13-10-19)36-21-11-4-16(2)22(14-21)23(32)33/h4-14H,3,15H2,1-2H3,(H,32,33)(H,28,29,34) NMYMELHQAXYDEI-UHFFFAOYSA-N 265831 US9718790, I-2017 P2X purinoceptor 3 Homo sapiens 41.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265831 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265831&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945316 377004703 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505394 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n(CC(=O)NO)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C21H21ClFN5O5/c1-12(2)33-17-8-7-15(9-16(17)23)24-19-25-20(30)28(11-18(29)26-32)21(31)27(19)10-13-3-5-14(22)6-4-13/h3-9,12,32H,10-11H2,1-2H3,(H,26,29)(H,24,25,30) ZFGALUBNBXZRDX-UHFFFAOYSA-N 265832 US9718790, I-0636 P2X purinoceptor 3 Homo sapiens 10.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265832 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265832&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 88558721 377004704 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505395 CC(C)Oc1ccc(Cn2c(=O)n(Cc3ccc(Cl)cc3)c(=O)n(C(C)C)c2=O)cc1 InChI=1S/C23H26ClN3O4/c1-15(2)27-22(29)25(13-17-5-9-19(24)10-6-17)21(28)26(23(27)30)14-18-7-11-20(12-8-18)31-16(3)4/h5-12,15-16H,13-14H2,1-4H3 WZTUOSTZVHLACN-UHFFFAOYSA-N 265833 US9718790, I-1291 P2X purinoceptor 3 Homo sapiens 683 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265833 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265833&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019693 377004705 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505396 Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccnc(CO)c3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H20ClN5O4/c1-28-22(31)27-21(29(23(28)32)13-15-2-4-16(24)5-3-15)26-17-6-8-19(9-7-17)33-20-10-11-25-18(12-20)14-30/h2-12,30H,13-14H2,1H3,(H,26,27,31) CWEAINCGMXRZSG-UHFFFAOYSA-N 265834 US9718790, I-2018 P2X purinoceptor 3 Homo sapiens 22.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265834 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265834&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945315 377004706 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505397 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(F)cc1 265835 US9718790, I-0637 P2X purinoceptor 3 Homo sapiens 69.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265835 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265835&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019539 377004707 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505398 CC(C)Oc1cccc(Cn2c(=O)n(Cc3ccc(Cl)cc3)c(=O)n(C(C)C)c2=O)c1 InChI=1S/C23H26ClN3O4/c1-15(2)27-22(29)25(13-17-8-10-19(24)11-9-17)21(28)26(23(27)30)14-18-6-5-7-20(12-18)31-16(3)4/h5-12,15-16H,13-14H2,1-4H3 KVSFFUJLIRAIRO-UHFFFAOYSA-N 265836 US9718790, I-1292 P2X purinoceptor 3 Homo sapiens 445 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265836 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265836&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019674 377004708 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505399 CNC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(Cl)c2)n(CC2CCC(C)CC2)c1=O InChI=1S/C24H34ClN5O4/c1-15(2)34-20-10-9-18(13-19(20)25)27-22-28-23(32)29(12-11-21(31)26-4)24(33)30(22)14-17-7-5-16(3)6-8-17/h9-10,13,15-17H,5-8,11-12,14H2,1-4H3,(H,26,31)(H,27,28,32) YZHMFWZEHAPWPR-UHFFFAOYSA-N 265837 US9718790, I-2019 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265837 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265837&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945622 377004709 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505400 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(C[C@H](O)CO)c(=O)n1Cc1ccc(Cl)cc1 265838 US9718790, I-0638 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265838 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265838&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019522 377004710 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505401 CC(C)Oc1ccc(Nc2nc(OCc3ccc(Cl)cc3)n(c(=O)n2)C(C)(C)C)cc1F InChI=1S/C23H26ClFN4O3/c1-14(2)32-19-11-10-17(12-18(19)25)26-20-27-21(30)29(23(3,4)5)22(28-20)31-13-15-6-8-16(24)9-7-15/h6-12,14H,13H2,1-5H3,(H,26,27,30) KHBVFOXXHANCGG-UHFFFAOYSA-N 265839 US9718790, I-1296 P2X purinoceptor 3 Homo sapiens 918 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265839 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265839&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020137 377004711 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505402 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(CCC(N)=O)c(=O)n1CC1CCC(C)CC1 InChI=1S/C23H32ClN5O4/c1-14(2)33-19-9-8-17(12-18(19)24)26-21-27-22(31)28(11-10-20(25)30)23(32)29(21)13-16-6-4-15(3)5-7-16/h8-9,12,14-16H,4-7,10-11,13H2,1-3H3,(H2,25,30)(H,26,27,31) ZFEJEIMWWGUWEY-UHFFFAOYSA-N 265840 US9718790, I-2020 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265840 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265840&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019857 377004712 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505403 CC(C)Oc1ccc(cc1)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(F)cc1 265841 US9718790, I-0639 P2X purinoceptor 3 Homo sapiens 216 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265841 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265841&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019523 377004713 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505404 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n(Cc2nnn[nH]2)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C21H20ClFN8O3/c1-12(2)34-17-8-7-15(9-16(17)23)24-19-25-20(32)31(11-18-26-28-29-27-18)21(33)30(19)10-13-3-5-14(22)6-4-13/h3-9,12H,10-11H2,1-2H3,(H,24,25,32)(H,26,27,28,29) REVAMAOBSMUYAP-UHFFFAOYSA-N 265842 US9718790, I-1297 P2X purinoceptor 3 Homo sapiens 26.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265842 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265842&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 86689086 377004714 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505405 CCn1c(=O)[nH]\c(=N/c2ccc(OCC3(CC3)C(O)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H23ClN4O5/c1-2-27-21(31)26-20(28(22(27)32)13-15-3-5-16(24)6-4-15)25-17-7-9-18(10-8-17)33-14-23(11-12-23)19(29)30/h3-10H,2,11-14H2,1H3,(H,29,30)(H,25,26,31) QNSMHWRAHVPBHJ-UHFFFAOYSA-N 265843 US9718790, I-2021 P2X purinoceptor 3 Homo sapiens 230 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265843 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265843&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020544 377004715 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505406 COC(=O)C(C)(C)n1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(Cl)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H26Cl2N4O5/c1-14(2)35-19-11-10-17(12-18(19)26)27-21-28-22(32)30(24(3,4)20(31)34-5)23(33)29(21)13-15-6-8-16(25)9-7-15/h6-12,14H,13H2,1-5H3,(H,27,28,32) BNLUNSAJMFCMAT-UHFFFAOYSA-N 265844 US9718790, I-0640 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265844 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265844&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019521 377004716 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505407 CCOC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(CC(C)C)c(F)c2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C26H31FN4O4/c1-5-35-23(32)12-13-30-25(33)29-24(28-21-11-10-20(14-17(2)3)22(27)15-21)31(26(30)34)16-19-8-6-18(4)7-9-19/h6-11,15,17H,5,12-14,16H2,1-4H3,(H,28,29,33) SWIMFHCGGGLHCT-UHFFFAOYSA-N 265845 US9718790, I-1298 P2X purinoceptor 3 Homo sapiens 26.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265845 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265845&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020107 377004717 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505408 C[C@H]1CCC(Cn2c(=O)n(CCO)c(=O)[nH]\c2=N/c2ccc(Oc3ccnc(O)c3)cc2)CC1 265846 US9718790, I-2022 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265846 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265846&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020636 377004718 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505409 COc1ccc(Cn2c(=O)[nH]\c(=N/c3ccc(OC(C)C)c(F)c3)n(Cc3ccc(Cl)cc3)c2=O)cn1 InChI=1S/C26H25ClFN5O4/c1-16(2)37-22-10-9-20(12-21(22)28)30-24-31-25(34)33(15-18-6-11-23(36-3)29-13-18)26(35)32(24)14-17-4-7-19(27)8-5-17/h4-13,16H,14-15H2,1-3H3,(H,30,31,34) CGKRERJVEAOEKU-UHFFFAOYSA-N 265847 US9718790, I-0641 P2X purinoceptor 3 Homo sapiens 26.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265847 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265847&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020736 377004719 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505410 CC(C)Cc1ccc(cc1F)\N=c1/[nH]c(=O)n(CCC(O)=O)c(=O)n1Cc1ccc(C)cc1 InChI=1S/C24H27FN4O4/c1-15(2)12-18-8-9-19(13-20(18)25)26-22-27-23(32)28(11-10-21(30)31)24(33)29(22)14-17-6-4-16(3)5-7-17/h4-9,13,15H,10-12,14H2,1-3H3,(H,30,31)(H,26,27,32) CUFKECOSCZUKTA-UHFFFAOYSA-N 265848 US9718790, I-1299 P2X purinoceptor 3 Homo sapiens 51.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265848 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265848&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020199 377004720 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505411 COC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(Cl)c2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C24H27ClN4O5/c1-15(2)34-20-10-9-18(13-19(20)25)26-22-27-23(31)28(12-11-21(30)33-4)24(32)29(22)14-17-7-5-16(3)6-8-17/h5-10,13,15H,11-12,14H2,1-4H3,(H,26,27,31) HLPOZWDZJYPRDX-UHFFFAOYSA-N 265849 US9718790, I-2023 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265849 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265849&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020546 377004721 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505412 COc1cc(Cn2c(=O)[nH]\c(=N/c3ccc(OC(C)C)c(F)c3)n(Cc3ccc(Cl)cc3)c2=O)ccn1 InChI=1S/C26H25ClFN5O4/c1-16(2)37-22-9-8-20(13-21(22)28)30-24-31-25(34)33(15-18-10-11-29-23(12-18)36-3)26(35)32(24)14-17-4-6-19(27)7-5-17/h4-13,16H,14-15H2,1-3H3,(H,30,31,34) NSPMEWFXPZBBRC-UHFFFAOYSA-N 265850 US9718790, I-0642 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265850 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265850&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019545 377004722 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505413 CCOC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(c2)C2CC2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C28H34N4O5/c1-5-36-25(33)14-15-31-27(34)30-26(32(28(31)35)17-20-8-6-19(4)7-9-20)29-22-12-13-24(37-18(2)3)23(16-22)21-10-11-21/h6-9,12-13,16,18,21H,5,10-11,14-15,17H2,1-4H3,(H,29,30,34) BPYCHXNIKIGXPN-UHFFFAOYSA-N 265851 US9718790, I-1300 P2X purinoceptor 3 Homo sapiens 18.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265851 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265851&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945385 377004723 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505414 Clc1ccc(Cn2c(=O)n(CCOC3CCCCO3)c(=O)[nH]\c2=N/c2ccc3nc(sc3c2)C2CC2)cc1 265852 US9718790, I-2024 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265852 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265852&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020549 377004724 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505415 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n(Cc2n[nH]c(=O)o2)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C22H20ClFN6O5/c1-12(2)34-17-8-7-15(9-16(17)24)25-19-26-20(31)30(11-18-27-28-21(32)35-18)22(33)29(19)10-13-3-5-14(23)6-4-13/h3-9,12H,10-11H2,1-2H3,(H,28,32)(H,25,26,31) HUQWLGOFJZUNBL-UHFFFAOYSA-N 265853 US9718790, I-0643 P2X purinoceptor 3 Homo sapiens 54.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265853 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265853&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019546 377004725 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505416 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(C=C(C)C)nc2)n(Cc2ccc(C)cc2)c1=O 265854 US9718790, I-1301 P2X purinoceptor 3 Homo sapiens 514 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265854 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265854&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020412 377004726 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505417 Cc1cc2cc(ccc2o1)\N=c1/[nH]c(=O)n(CCCOC2CCCCO2)c(=O)n1Cc1ccc(Cl)cc1 265855 US9718790, I-2025 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265855 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265855&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020576 377004727 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505418 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n(CCC(=O)NN)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C22H24ClFN6O4/c1-13(2)34-18-8-7-16(11-17(18)24)26-20-27-21(32)29(10-9-19(31)28-25)22(33)30(20)12-14-3-5-15(23)6-4-14/h3-8,11,13H,9-10,12,25H2,1-2H3,(H,28,31)(H,26,27,32) JBVKTKIULRIALF-UHFFFAOYSA-N 265856 US9718790, I-0644 P2X purinoceptor 3 Homo sapiens 40.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265856 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265856&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019548 377004728 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505419 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(cc2)C(=O)C2CC2)n(Cc2ccc(C)cc2)c1=O 265857 US9718790, I-1302 P2X purinoceptor 3 Homo sapiens 169 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265857 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265857&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020414 377004729 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505420 OCCn1c(=O)[nH]\c(=N/c2ccc3nc(sc3c2)C2CC2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C22H20ClN5O3S/c23-15-5-1-13(2-6-15)12-28-20(26-21(30)27(9-10-29)22(28)31)24-16-7-8-17-18(11-16)32-19(25-17)14-3-4-14/h1-2,5-8,11,14,29H,3-4,9-10,12H2,(H,24,26,30) GBVANVAZPMAUAM-UHFFFAOYSA-N 265858 US9718790, I-2026 P2X purinoceptor 3 Homo sapiens 22.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265858 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265858&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020504 377004730 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505421 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n(CCCS(O)(=O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C22H24ClFN4O6S/c1-14(2)34-19-9-8-17(12-18(19)24)25-20-26-21(29)27(10-3-11-35(31,32)33)22(30)28(20)13-15-4-6-16(23)7-5-15/h4-9,12,14H,3,10-11,13H2,1-2H3,(H,25,26,29)(H,31,32,33) DLBUZGLKDIIQQE-UHFFFAOYSA-N 265859 US9718790, I-0645 P2X purinoceptor 3 Homo sapiens 102 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265859 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265859&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 88558725 377004731 C15521 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505422 CC(C)Oc1ccc(cc1C1CC1)\N=c1/[nH]c(=O)n(CCC(O)=O)c(=O)n1Cc1ccc(C)cc1 InChI=1S/C26H30N4O5/c1-16(2)35-22-11-10-20(14-21(22)19-8-9-19)27-24-28-25(33)29(13-12-23(31)32)26(34)30(24)15-18-6-4-17(3)5-7-18/h4-7,10-11,14,16,19H,8-9,12-13,15H2,1-3H3,(H,31,32)(H,27,28,33) CSEUKCYRTGCDDE-UHFFFAOYSA-N 265860 US9718790, I-1303 P2X purinoceptor 3 Homo sapiens 66.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265860 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265860&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020417 377004732 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505423 Cc1cc2cc(ccc2o1)\N=c1/[nH]c(=O)n(CCCO)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C22H21ClN4O4/c1-14-11-16-12-18(7-8-19(16)31-14)24-20-25-21(29)26(9-2-10-28)22(30)27(20)13-15-3-5-17(23)6-4-15/h3-8,11-12,28H,2,9-10,13H2,1H3,(H,24,25,29) AJMYWVVDQHNKRW-UHFFFAOYSA-N 265861 US9718790, I-2027 P2X purinoceptor 3 Homo sapiens 17.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265861 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265861&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020506 377004733 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505424 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n(CCc2n[nH]c(=O)o2)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C23H22ClFN6O5/c1-13(2)35-18-8-7-16(11-17(18)25)26-20-27-21(32)30(10-9-19-28-29-22(33)36-19)23(34)31(20)12-14-3-5-15(24)6-4-14/h3-8,11,13H,9-10,12H2,1-2H3,(H,29,33)(H,26,27,32) XCVXTBKXMXYMDB-UHFFFAOYSA-N 265862 US9718790, I-0646 P2X purinoceptor 3 Homo sapiens 28.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265862 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265862&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 89666644 377004734 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505425 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(C=C(C)C)nc2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 265863 US9718790, I-1304 P2X purinoceptor 3 Homo sapiens 574 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265863 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265863&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020444 377004735 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505532 COc1ncccc1Cn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H25ClFN5O4/c1-16(2)37-22-11-10-20(13-21(22)28)30-24-31-25(34)33(15-18-5-4-12-29-23(18)36-3)26(35)32(24)14-17-6-8-19(27)9-7-17/h4-13,16H,14-15H2,1-3H3,(H,30,31,34) KBXQZNOODOMKQX-UHFFFAOYSA-N 265970 US9718790, I-0683 P2X purinoceptor 3 Homo sapiens 9.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265970 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265970&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278461 377004842 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505533 C[C@@H]([C@@H](C)n1c(=O)[nH]\c(=N/c2ccc(OCC3CC3)cc2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 265971 US9718790, I-1341 P2X purinoceptor 3 Homo sapiens 36.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265971 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265971&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278333 377004843 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505534 Cc1cc2cc(ccc2o1)\N=c1/[nH]c(=O)n(CC2COC(C)(C)OC2)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C26H27ClN4O5/c1-16-10-19-11-21(8-9-22(19)36-16)28-23-29-24(32)31(13-18-14-34-26(2,3)35-15-18)25(33)30(23)12-17-4-6-20(27)7-5-17/h4-11,18H,12-15H2,1-3H3,(H,28,29,32) UMCLPIJBRYXBLR-UHFFFAOYSA-N 265972 US9718790, I-2069 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265972 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265972&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021137 377004844 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505535 COc1ccc(CN2[C@H](Cn3c(=O)[nH]\c(=N/c4ccc(OC(C)C)c(F)c4)n(Cc4ccc(Cl)cc4)c3=O)CCC2=O)cc1 265973 US9718790, I-0684 P2X purinoceptor 3 Homo sapiens 30.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265973 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265973&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945012 377004845 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505536 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n([C@H](C)[C@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 265974 US9718790, I-1342 P2X purinoceptor 3 Homo sapiens 10.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265974 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265974&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278188 377004846 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505537 Cc1cc2cc(ccc2o1)\N=c1/[nH]c(=O)n(CC(CO)CO)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C23H23ClN4O5/c1-14-8-17-9-19(6-7-20(17)33-14)25-21-26-22(31)28(11-16(12-29)13-30)23(32)27(21)10-15-2-4-18(24)5-3-15/h2-9,16,29-30H,10-13H2,1H3,(H,25,26,31) LYHYYRBXZKUHGH-UHFFFAOYSA-N 265975 US9718790, I-2070 P2X purinoceptor 3 Homo sapiens 19.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265975 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265975&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021138 377004847 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505538 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n(Cc2ccc[nH]c2=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C25H23ClFN5O4/c1-15(2)36-21-10-9-19(12-20(21)27)29-23-30-24(34)32(14-17-4-3-11-28-22(17)33)25(35)31(23)13-16-5-7-18(26)8-6-16/h3-12,15H,13-14H2,1-2H3,(H,28,33)(H,29,30,34) DZHJETCWBYYEQS-UHFFFAOYSA-N 265976 US9718790, I-0685 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265976 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265976&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 135121018 377004848 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505539 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n([C@H](C)[C@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 265977 US9718790, I-1343 P2X purinoceptor 3 Homo sapiens 35.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265977 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265977&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021050 377004849 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505540 Cc1oc2ccc(cc2c1C)\N=c1/[nH]c(=O)n(CC2COC(C)(C)OC2)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C27H29ClN4O5/c1-16-17(2)37-23-10-9-21(11-22(16)23)29-24-30-25(33)32(13-19-14-35-27(3,4)36-15-19)26(34)31(24)12-18-5-7-20(28)8-6-18/h5-11,19H,12-15H2,1-4H3,(H,29,30,33) COTYBQCSYIKFCP-UHFFFAOYSA-N 265978 US9718790, I-2071 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265978 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265978&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278600 377004850 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505541 COCc1ccc(cc1)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 265979 US9718790, I-0686 P2X purinoceptor 3 Homo sapiens 605 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265979 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265979&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945171 377004851 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505542 C[C@@H]([C@@H](C)n1c(=O)[nH]\c(=N/c2ccc(OCC3CC3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 265980 US9718790, I-1344 P2X purinoceptor 3 Homo sapiens 33.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265980 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265980&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278248 377004852 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505543 Cc1oc2ccc(cc2c1C)\N=c1/[nH]c(=O)n(CC(CO)CO)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C24H25ClN4O5/c1-14-15(2)34-21-8-7-19(9-20(14)21)26-22-27-23(32)29(11-17(12-30)13-31)24(33)28(22)10-16-3-5-18(25)6-4-16/h3-9,17,30-31H,10-13H2,1-2H3,(H,26,27,32) UOONRMGNUWUAOO-UHFFFAOYSA-N 265981 US9718790, I-2072 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265981 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265981&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278601 377004853 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505544 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(c(=O)n1Cc1ccc(Cl)cc1)C(C)(C)C(=O)NC(CO)CO InChI=1S/C26H31Cl2N5O6/c1-15(2)39-21-10-9-18(11-20(21)28)30-23-31-24(37)33(26(3,4)22(36)29-19(13-34)14-35)25(38)32(23)12-16-5-7-17(27)8-6-16/h5-11,15,19,34-35H,12-14H2,1-4H3,(H,29,36)(H,30,31,37) LITDVSSHHIBLSD-UHFFFAOYSA-N 265982 US9718790, I-0687 P2X purinoceptor 3 Homo sapiens 12.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265982 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265982&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020768 377004854 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505545 C[C@@H]([C@@H](C)n1c(=O)[nH]\c(=N/c2cccc(c2)C(F)(F)F)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 265983 US9718790, I-1345 P2X purinoceptor 3 Homo sapiens 69.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265983 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265983&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021058 377004855 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505546 Cc1oc2ccc(cc2c1C)\N=c1/[nH]c(=O)n(CCCOC2CCCCO2)c(=O)n1Cc1ccc(Cl)cc1 265984 US9718790, I-2073 P2X purinoceptor 3 Homo sapiens 10.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265984 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265984&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278314 377004856 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505547 COc1ccc(CN2[C@@H](Cn3c(=O)[nH]\c(=N/c4ccc(OC(C)C)c(F)c4)n(Cc4ccc(Cl)cc4)c3=O)CCC2=O)cc1 265985 US9718790, I-0688 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265985 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265985&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278263 377004857 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505548 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc3ncccc3c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 265986 US9718790, I-1346 P2X purinoceptor 3 Homo sapiens 812 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265986 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265986&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020141 377004858 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505549 Cc1oc2ccc(cc2c1C)\N=c1/[nH]c(=O)n(CCCO)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C23H23ClN4O4/c1-14-15(2)32-20-9-8-18(12-19(14)20)25-21-26-22(30)27(10-3-11-29)23(31)28(21)13-16-4-6-17(24)7-5-16/h4-9,12,29H,3,10-11,13H2,1-2H3,(H,25,26,30) IZQDLJQDKYCXBH-UHFFFAOYSA-N 265987 US9718790, I-2074 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265987 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265987&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945410 377004859 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505550 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n(Cc2cccn(C)c2=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C26H25ClFN5O4/c1-16(2)37-22-11-10-20(13-21(22)28)29-24-30-25(35)33(15-18-5-4-12-31(3)23(18)34)26(36)32(24)14-17-6-8-19(27)9-7-17/h4-13,16H,14-15H2,1-3H3,(H,29,30,35) JHRPUGFZXRRJLT-UHFFFAOYSA-N 265988 US9718790, I-0689 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265988 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265988&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020766 377004860 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505551 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc3nc(C)c(C)nc3c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 265989 US9718790, I-1348 P2X purinoceptor 3 Homo sapiens 918 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265989 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265989&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020260 377004861 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505552 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cncc(CO)c3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H22ClN5O4/c1-2-29-23(32)28-22(30(24(29)33)14-16-3-5-18(25)6-4-16)27-19-7-9-20(10-8-19)34-21-11-17(15-31)12-26-13-21/h3-13,31H,2,14-15H2,1H3,(H,27,28,32) DDDQZKFPPCKENF-UHFFFAOYSA-N 265990 US9718790, I-2075 P2X purinoceptor 3 Homo sapiens 21.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265990 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265990&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278315 377004862 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505553 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(C)c(Cl)c2)n(Cc2ccc(Cl)cc2)c1=O 265991 US9718790, I-0691 P2X purinoceptor 3 Homo sapiens 48.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265991 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265991&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020100 377004863 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505554 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc3nc(C)sc3c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 265992 US9718790, I-1349 P2X purinoceptor 3 Homo sapiens 15.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265992 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265992&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020114 377004864 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505555 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cncc(c3)C(=O)OC)cc2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C26H25N5O5/c1-4-30-25(33)29-24(31(26(30)34)16-18-7-5-17(2)6-8-18)28-20-9-11-21(12-10-20)36-22-13-19(14-27-15-22)23(32)35-3/h5-15H,4,16H2,1-3H3,(H,28,29,33) MEUYBAACXFNSQU-UHFFFAOYSA-N 265993 US9718790, I-2076 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265993 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265993&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020192 377004865 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505556 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc3[nH]c(C)cc3c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H22ClN5O4/c1-14(21(31)34-3)12-30-23(32)28-22(27-19-8-9-20-17(11-19)10-15(2)26-20)29(24(30)33)13-16-4-6-18(25)7-5-16/h4-11,14H,12-13H2,1-3H3/b27-19+/t14-/m0/s1 LCXPUVCDZSKTAC-LRNUDVLQSA-N 265994 US9718790, I-0692 P2X purinoceptor 3 Homo sapiens 29.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265994 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265994&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020075 377004866 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505557 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc3nc(C)ccc3c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 265995 US9718790, I-1350 P2X purinoceptor 3 Homo sapiens 28.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265995 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265995&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278323 377004867 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505558 OCc1cncc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(CCOC3CCCCO3)c(=O)n2Cc2ccc(Cl)cc2)c1 265996 US9718790, I-2077 P2X purinoceptor 3 Homo sapiens 3.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265996 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265996&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020312 377004868 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505559 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n(CCS(N)(=O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C21H23ClFN5O5S/c1-13(2)33-18-8-7-16(11-17(18)23)25-19-26-20(29)27(9-10-34(24,31)32)21(30)28(19)12-14-3-5-15(22)6-4-14/h3-8,11,13H,9-10,12H2,1-2H3,(H2,24,31,32)(H,25,26,29) AUONUFASHMILGI-UHFFFAOYSA-N 265997 US9718790, I-0693 P2X purinoceptor 3 Homo sapiens 13.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265997 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265997&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020146 377004869 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505560 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc3oc(C)cc3c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 265998 US9718790, I-1351 P2X purinoceptor 3 Homo sapiens 41.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265998 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265998&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020898 377004870 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505561 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cncc(c3)C(O)=O)cc2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C25H23N5O5/c1-3-29-24(33)28-23(30(25(29)34)15-17-6-4-16(2)5-7-17)27-19-8-10-20(11-9-19)35-21-12-18(22(31)32)13-26-14-21/h4-14H,3,15H2,1-2H3,(H,31,32)(H,27,28,33) RTVWASNVOZCFLB-UHFFFAOYSA-N 265999 US9718790, I-2078 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265999 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265999&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020270 377004871 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505562 CCOC(=O)C1(Cn2c(=O)[nH]\c(=N/c3ccc(OC(C)C)c(C)c3)n(Cc3ccc(Cl)cc3)c2=O)CC1 InChI=1S/C27H31ClN4O5/c1-5-36-23(33)27(12-13-27)16-32-25(34)30-24(29-21-10-11-22(18(4)14-21)37-17(2)3)31(26(32)35)15-19-6-8-20(28)9-7-19/h6-11,14,17H,5,12-13,15-16H2,1-4H3,(H,29,30,34) WVQCYXFGGLJCAJ-UHFFFAOYSA-N 266000 US9718790, I-0694 P2X purinoceptor 3 Homo sapiens 13.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266000 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266000&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019982 377004872 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505563 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc3nc(C)ccc3c2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 266001 US9718790, I-1352 P2X purinoceptor 3 Homo sapiens 26.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266001 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266001&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945390 377004873 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505564 OCCn1c(=O)[nH]\c(=N/c2ccc(Oc3cncc(CO)c3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H22ClN5O5/c25-18-3-1-16(2-4-18)14-30-22(28-23(33)29(9-10-31)24(30)34)27-19-5-7-20(8-6-19)35-21-11-17(15-32)12-26-13-21/h1-8,11-13,31-32H,9-10,14-15H2,(H,27,28,33) RSLYAMWFZNJSIR-UHFFFAOYSA-N 266002 US9718790, I-2079 P2X purinoceptor 3 Homo sapiens 38.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266002 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266002&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020226 377004874 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505565 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(C)c(Cl)c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 266003 US9718790, I-0696 P2X purinoceptor 3 Homo sapiens 129 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266003 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266003&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020935 377004875 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505566 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc3oc(C)cc3c2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 266004 US9718790, I-1353 P2X purinoceptor 3 Homo sapiens 41.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266004 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266004&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020888 377004876 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505567 Cc1ccc(Cn2\c(=N\c3cc(ccc3C)C(F)(F)F)[nH]c(=O)n(CCC(O)=O)c2=O)cc1 InChI=1S/C22H21F3N4O4/c1-13-3-6-15(7-4-13)12-29-19(27-20(32)28(21(29)33)10-9-18(30)31)26-17-11-16(22(23,24)25)8-5-14(17)2/h3-8,11H,9-10,12H2,1-2H3,(H,30,31)(H,26,27,32) PISAABMAIXGRMT-UHFFFAOYSA-N 266005 US9718790, I-2082 P2X purinoceptor 3 Homo sapiens 833 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266005 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266005&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021189 377004877 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505568 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc3[nH]c(C)cc3c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O InChI=1S/C23H20ClN5O4/c1-13(20(30)31)11-29-22(32)27-21(26-18-7-8-19-16(10-18)9-14(2)25-19)28(23(29)33)12-15-3-5-17(24)6-4-15/h3-10,13H,11-12H2,1-2H3,(H,30,31)/b26-18+/t13-/m0/s1 XKPJIYLCQGKUIZ-WVFAEZDRSA-N 266006 US9718790, I-0697 P2X purinoceptor 3 Homo sapiens 57.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266006 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266006&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020926 377004878 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505569 CCCc1ccc(cc1OC)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 266007 US9718790, I-1354 P2X purinoceptor 3 Homo sapiens 139 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266007 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266007&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020885 377004879 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505570 Cc1ccc(Cn2\c(=N\c3cccc(c3C)C(F)(F)F)[nH]c(=O)n(CCC(O)=O)c2=O)cc1 InChI=1S/C22H21F3N4O4/c1-13-6-8-15(9-7-13)12-29-19(27-20(32)28(21(29)33)11-10-18(30)31)26-17-5-3-4-16(14(17)2)22(23,24)25/h3-9H,10-12H2,1-2H3,(H,30,31)(H,26,27,32) NLCBFRKZWWWSAI-UHFFFAOYSA-N 266008 US9718790, I-2085 P2X purinoceptor 3 Homo sapiens 852 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266008 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266008&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021140 377004880 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505571 CC(C)Oc1ccc(cc1C)\N=c1/[nH]c(=O)n(CC2(CC2)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C25H27ClN4O5/c1-15(2)35-20-9-8-19(12-16(20)3)27-22-28-23(33)30(14-25(10-11-25)21(31)32)24(34)29(22)13-17-4-6-18(26)7-5-17/h4-9,12,15H,10-11,13-14H2,1-3H3,(H,31,32)(H,27,28,33) GHXMDMOUJSJNAJ-UHFFFAOYSA-N 266009 US9718790, I-0698 P2X purinoceptor 3 Homo sapiens 26.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266009 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266009&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278161 377004881 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505572 COc1cc(ccc1CC(C)C)\N=c1/[nH]c(=O)n(CCC(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C24H27ClN4O5/c1-15(2)12-17-6-9-19(13-20(17)34-3)26-22-27-23(32)28(11-10-21(30)31)24(33)29(22)14-16-4-7-18(25)8-5-16/h4-9,13,15H,10-12,14H2,1-3H3,(H,30,31)(H,26,27,32) KGLPFOUZQXSBCE-UHFFFAOYSA-N 266010 US9718790, I-1355 P2X purinoceptor 3 Homo sapiens 177 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266010 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266010&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020890 377004882 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505573 Cc1ccc(Cn2\c(=N\c3cccc(c3F)C(F)(F)F)[nH]c(=O)n(CCC(O)=O)c2=O)cc1 InChI=1S/C21H18F4N4O4/c1-12-5-7-13(8-6-12)11-29-18(27-19(32)28(20(29)33)10-9-16(30)31)26-15-4-2-3-14(17(15)22)21(23,24)25/h2-8H,9-11H2,1H3,(H,30,31)(H,26,27,32) UQDNDHAICJQXSJ-UHFFFAOYSA-N 266011 US9718790, I-2086 P2X purinoceptor 3 Homo sapiens 234 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266011 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266011&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278631 377004883 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505574 COC(=O)[C@@H]1CC(CN1C(=O)OC(C)(C)C)n1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O 266012 US9718790, I-0699 P2X purinoceptor 3 Homo sapiens 37.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266012 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266012&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278271 377004884 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505575 Cc1ccc(Cn2c(=O)n(CCC(O)=O)c(=O)[nH]\c2=N/c2ccc(Oc3ccc(C)nc3)cc2)cc1 InChI=1S/C26H25N5O5/c1-17-3-6-19(7-4-17)16-31-24(29-25(34)30(26(31)35)14-13-23(32)33)28-20-8-11-21(12-9-20)36-22-10-5-18(2)27-15-22/h3-12,15H,13-14,16H2,1-2H3,(H,32,33)(H,28,29,34) PUSWWJDJBXALMP-UHFFFAOYSA-N 266013 US9718790, I-1356 P2X purinoceptor 3 Homo sapiens 48.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266013 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266013&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278189 377004885 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505576 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(n3)C(O)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H20ClN5O5/c1-2-29-23(33)28-22(30(24(29)34)14-15-6-8-16(25)9-7-15)26-17-10-12-18(13-11-17)35-20-5-3-4-19(27-20)21(31)32/h3-13H,2,14H2,1H3,(H,31,32)(H,26,28,33) FWSHHPRTXNMRGV-UHFFFAOYSA-N 266014 US9718790, I-2095 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266014 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266014&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945400 377004886 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505577 COC(=O)c1ccc(Cn2c(=O)[nH]\c(=N/c3ccc(OC(C)C)c(C)c3)n(Cc3ccc(Cl)cc3)c2=O)o1 InChI=1S/C27H27ClN4O6/c1-16(2)37-22-11-9-20(13-17(22)3)29-25-30-26(34)32(15-21-10-12-23(38-21)24(33)36-4)27(35)31(25)14-18-5-7-19(28)8-6-18/h5-13,16H,14-15H2,1-4H3,(H,29,30,34) QLHXBXAHGBSHSZ-UHFFFAOYSA-N 266015 US9718790, I-0700 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266015 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266015&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020928 377004887 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505578 Cc1ccc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(CCC(O)=O)c(=O)n2Cc2ccc(Cl)cc2)cn1 InChI=1S/C25H22ClN5O5/c1-16-2-9-21(14-27-16)36-20-10-7-19(8-11-20)28-23-29-24(34)30(13-12-22(32)33)25(35)31(23)15-17-3-5-18(26)6-4-17/h2-11,14H,12-13,15H2,1H3,(H,32,33)(H,28,29,34) RLOIYWAMNDJQBM-UHFFFAOYSA-N 266016 US9718790, I-1357 P2X purinoceptor 3 Homo sapiens 25.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266016 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266016&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020863 377004888 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505579 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3nccc(OC)n3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H21ClN6O4/c1-3-29-22(31)28-20(30(23(29)32)14-15-4-6-16(24)7-5-15)26-17-8-10-18(11-9-17)34-21-25-13-12-19(27-21)33-2/h4-13H,3,14H2,1-2H3,(H,26,28,31) AZFVUDHBXOVAHB-UHFFFAOYSA-N 266017 US9718790, I-2096 P2X purinoceptor 3 Homo sapiens 35.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266017 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266017&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021112 377004889 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505580 CCC(Cn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O)C(=O)OC(C)(C)C 266018 US9718790, I-0701 P2X purinoceptor 3 Homo sapiens 35.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266018 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266018&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020781 377004890 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505581 Cc1ccc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n2Cc2ccc(Cl)cc2)cn1 InChI=1S/C27H26ClN5O5/c1-17-4-11-22(14-29-17)38-21-12-9-20(10-13-21)30-24-31-25(36)33(16-27(2,3)23(34)35)26(37)32(24)15-18-5-7-19(28)8-6-18/h4-14H,15-16H2,1-3H3,(H,34,35)(H,30,31,36) YMFNWYBHHOZALR-UHFFFAOYSA-N 266019 US9718790, I-1358 P2X purinoceptor 3 Homo sapiens 9.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266019 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266019&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278190 377004891 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505582 C[C@H]1CCC(Cn2c(=O)n(C[C@H](O)CO)c(=O)[nH]\c2=N/c2ccc3nc(C)sc3c2)CC1 266020 US9718790, I-2097 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266020 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266020&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021157 377004892 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505583 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(OC)c(Cl)c2)n(Cc2ccc(Cl)cc2)c1=O 266021 US9718790, I-0702 P2X purinoceptor 3 Homo sapiens 107 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266021 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266021&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020786 377004893 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505584 CC(C)Cc1ccc(cn1)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(C)cc1 266022 US9718790, I-1359 P2X purinoceptor 3 Homo sapiens 724 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266022 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266022&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020893 377004894 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505585 C[C@H]1CCC(Cn2c(=O)n(CCO)c(=O)[nH]\c2=N/c2ccc3nc(C)sc3c2)CC1 266023 US9718790, I-2098 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266023 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266023&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021161 377004895 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505586 CNC(=O)C1(Cn2c(=O)[nH]\c(=N/c3ccc(OC(C)C)c(C)c3)n(Cc3ccc(Cl)cc3)c2=O)CC1 InChI=1S/C26H30ClN5O4/c1-16(2)36-21-10-9-20(13-17(21)3)29-23-30-24(34)32(15-26(11-12-26)22(33)28-4)25(35)31(23)14-18-5-7-19(27)8-6-18/h5-10,13,16H,11-12,14-15H2,1-4H3,(H,28,33)(H,29,30,34) KBPVNHHZZKSEQG-UHFFFAOYSA-N 266024 US9718790, I-0703 P2X purinoceptor 3 Homo sapiens 15.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266024 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266024&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020783 377004896 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505587 CCCc1ccc(cc1OC)\N=c1/[nH]c(=O)n(C[C@H](C)C(=O)OC)c(=O)n1Cc1ccc(C)cc1 266025 US9718790, I-1360 P2X purinoceptor 3 Homo sapiens 32.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266025 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266025&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020853 377004897 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505588 Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccnc(c3)C(O)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H18ClN5O5/c1-28-22(32)27-21(29(23(28)33)13-14-2-4-15(24)5-3-14)26-16-6-8-17(9-7-16)34-18-10-11-25-19(12-18)20(30)31/h2-12H,13H2,1H3,(H,30,31)(H,26,27,32) CXCDYUUTRFPBDW-UHFFFAOYSA-N 266026 US9718790, I-2099 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266026 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266026&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021144 377004898 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505589 CC(C)Oc1ccc(cc1C)\N=c1/[nH]c(=O)n(CC2(CC2)C(=O)NCCO)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C27H32ClN5O5/c1-17(2)38-22-9-8-21(14-18(22)3)30-24-31-25(36)33(16-27(10-11-27)23(35)29-12-13-34)26(37)32(24)15-19-4-6-20(28)7-5-19/h4-9,14,17,34H,10-13,15-16H2,1-3H3,(H,29,35)(H,30,31,36) OPNTVGSQNUWQKZ-UHFFFAOYSA-N 266027 US9718790, I-0704 P2X purinoceptor 3 Homo sapiens 23.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266027 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266027&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020784 377004899 C04080 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505590 CCOC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(CC(C)C)c(OC)c2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C27H34N4O5/c1-6-36-24(32)13-14-30-26(33)29-25(31(27(30)34)17-20-9-7-19(4)8-10-20)28-22-12-11-21(15-18(2)3)23(16-22)35-5/h7-12,16,18H,6,13-15,17H2,1-5H3,(H,28,29,33) BHAMRTOSLKQBME-UHFFFAOYSA-N 266028 US9718790, I-1361 P2X purinoceptor 3 Homo sapiens 15.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266028 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266028&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019922 377004900 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505591 Cc1ccc(Cn2c(=O)n(C)c(=O)[nH]\c2=N/c2ccc(Oc3ccnc(c3)C(O)=O)cc2)cc1 InChI=1S/C24H21N5O5/c1-15-3-5-16(6-4-15)14-29-22(27-23(32)28(2)24(29)33)26-17-7-9-18(10-8-17)34-19-11-12-25-20(13-19)21(30)31/h3-13H,14H2,1-2H3,(H,30,31)(H,26,27,32) IBDYBUKWSMIOLE-UHFFFAOYSA-N 266029 US9718790, I-2100 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266029 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266029&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021115 377004901 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505592 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(c(=O)n1Cc1ccc(Cl)cc1)C(C)(C)C(=O)NCCO InChI=1S/C25H29Cl2N5O5/c1-15(2)37-20-10-9-18(13-19(20)27)29-22-30-23(35)32(25(3,4)21(34)28-11-12-33)24(36)31(22)14-16-5-7-17(26)8-6-16/h5-10,13,15,33H,11-12,14H2,1-4H3,(H,28,34)(H,29,30,35) SNZPMWPPSVTGTJ-UHFFFAOYSA-N 266030 US9718790, I-0705 P2X purinoceptor 3 Homo sapiens 11.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266030 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266030&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130279094 377004902 C04080 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505593 COc1cc(ccc1CC(C)C)\N=c1/[nH]c(=O)n(CCC(O)=O)c(=O)n1Cc1ccc(C)cc1 InChI=1S/C25H30N4O5/c1-16(2)13-19-9-10-20(14-21(19)34-4)26-23-27-24(32)28(12-11-22(30)31)25(33)29(23)15-18-7-5-17(3)6-8-18/h5-10,14,16H,11-13,15H2,1-4H3,(H,30,31)(H,26,27,32) QSXPYKACJQVJSJ-UHFFFAOYSA-N 266031 US9718790, I-1362 P2X purinoceptor 3 Homo sapiens 54.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266031 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266031&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019923 377004903 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505594 CNC(=O)c1cc(Oc2ccc(cc2F)\N=c2/[nH]c(=O)[nH]c(=O)n2Cc2ccc(Cl)cc2)ccn1 InChI=1S/C23H18ClFN6O4/c1-26-20(32)18-11-16(8-9-27-18)35-19-7-6-15(10-17(19)25)28-21-29-22(33)30-23(34)31(21)12-13-2-4-14(24)5-3-13/h2-11H,12H2,1H3,(H,26,32)(H2,28,29,30,33,34) AAAMDLDGBNPDEO-UHFFFAOYSA-N 266032 US9718790, I-2101 P2X purinoceptor 3 Homo sapiens 26.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266032 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266032&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278390 377004904 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505595 CC(C)Oc1ccc(cc1C)\N=c1/[nH]c(=O)n(C[C@H]2CCC(=O)N2)c(=O)n1Cc1ccc(Cl)cc1 266033 US9718790, I-0706 P2X purinoceptor 3 Homo sapiens 14.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266033 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266033&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020960 377004905 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505596 COC(=O)[C@H](C)[C@H](C)n1c(=O)[nH]\c(=N/c2ccc(CC(C)C)c(OC)c2)n(Cc2ccc(Cl)cc2)c1=O 266034 US9718790, I-1363 P2X purinoceptor 3 Homo sapiens 56.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266034 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266034&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278506 377004906 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505597 Cc1ccc(Cn2c(=O)[nH]c(=O)[nH]\c2=N/c2ccc(Oc3cncc(c3)C(O)=O)cc2)cc1 InChI=1S/C23H19N5O5/c1-14-2-4-15(5-3-14)13-28-21(26-22(31)27-23(28)32)25-17-6-8-18(9-7-17)33-19-10-16(20(29)30)11-24-12-19/h2-12H,13H2,1H3,(H,29,30)(H2,25,26,27,31,32) SZZCXZSAVQFRFS-UHFFFAOYSA-N 266035 US9718790, I-2102 P2X purinoceptor 3 Homo sapiens 34.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266035 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266035&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945597 377004907 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505426 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(c3)C(=O)OC)cc2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C27H26N4O5/c1-4-30-26(33)29-25(31(27(30)34)17-19-10-8-18(2)9-11-19)28-21-12-14-22(15-13-21)36-23-7-5-6-20(16-23)24(32)35-3/h5-16H,4,17H2,1-3H3,(H,28,29,33) OIUWOGPDASQQHA-UHFFFAOYSA-N 265864 US9718790, I-2028 P2X purinoceptor 3 Homo sapiens 13.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265864 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265864&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020499 377004736 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505427 CC(C)Oc1ccc(cc1C)\N=c1/[nH]c(=O)n(C[C@@H](C)C(O)=O)c(=O)n1CC1CCCCC1 265865 US9718790, I-0647 P2X purinoceptor 3 Homo sapiens 316 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265865 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265865&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278196 377004737 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505428 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(cc2)C(=O)C2CC2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 265866 US9718790, I-1305 P2X purinoceptor 3 Homo sapiens 227 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265866 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265866&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020419 377004738 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505429 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(cc3)C(=O)OC)cc2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C27H26N4O5/c1-4-30-26(33)29-25(31(27(30)34)17-19-7-5-18(2)6-8-19)28-21-11-15-23(16-12-21)36-22-13-9-20(10-14-22)24(32)35-3/h5-16H,4,17H2,1-3H3,(H,28,29,33) SIXRRDUAFOOKRB-UHFFFAOYSA-N 265867 US9718790, I-2029 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265867 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265867&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020534 377004739 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505430 CCOc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(C[C@@H](C)C(O)=O)c(=O)n1CC1CCCCC1 265868 US9718790, I-0648 P2X purinoceptor 3 Homo sapiens 336 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265868 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265868&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278265 377004740 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505431 CCCc1ccc(cc1OC)\N=c1/[nH]c(=O)n(C[C@H](C)C(=O)OC)c(=O)n1Cc1ccc(Cl)cc1 265869 US9718790, I-1306 P2X purinoceptor 3 Homo sapiens 80.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265869 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265869&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021014 377004741 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505432 COC(=O)c1ccc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(C)c(=O)n2Cc2ccc(C)cc2)cc1 InChI=1S/C26H24N4O5/c1-17-4-6-18(7-5-17)16-30-24(28-25(32)29(2)26(30)33)27-20-10-14-22(15-11-20)35-21-12-8-19(9-13-21)23(31)34-3/h4-15H,16H2,1-3H3,(H,27,28,32) VXHNYHHSPKNMIV-UHFFFAOYSA-N 265870 US9718790, I-2030 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265870 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265870&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020614 377004742 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505433 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n(Cc2ccc(=O)[nH]c2)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C25H23ClFN5O4/c1-15(2)36-21-9-8-19(11-20(21)27)29-23-30-24(34)32(14-17-5-10-22(33)28-12-17)25(35)31(23)13-16-3-6-18(26)7-4-16/h3-12,15H,13-14H2,1-2H3,(H,28,33)(H,29,30,34) AYLHFASNWFEOMB-UHFFFAOYSA-N 265871 US9718790, I-0649 P2X purinoceptor 3 Homo sapiens 21.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265871 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265871&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 135121016 377004743 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505434 COC(=O)[C@H](C)[C@H](C)n1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(Br)c2)n(Cc2ccc(C)cc2)c1=O 265872 US9718790, I-1307 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265872 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265872&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278327 377004744 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505435 COC(=O)c1cccc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(C)c(=O)n2Cc2ccc(C)cc2)c1 InChI=1S/C26H24N4O5/c1-17-7-9-18(10-8-17)16-30-24(28-25(32)29(2)26(30)33)27-20-11-13-21(14-12-20)35-22-6-4-5-19(15-22)23(31)34-3/h4-15H,16H2,1-3H3,(H,27,28,32) BPHXVHOZIQZMTA-UHFFFAOYSA-N 265873 US9718790, I-2031 P2X purinoceptor 3 Homo sapiens 52.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265873 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265873&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278216 377004745 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505436 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n(Cc2cc[nH]c(=O)c2)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C25H23ClFN5O4/c1-15(2)36-21-8-7-19(12-20(21)27)29-23-30-24(34)32(14-17-9-10-28-22(33)11-17)25(35)31(23)13-16-3-5-18(26)6-4-16/h3-12,15H,13-14H2,1-2H3,(H,28,33)(H,29,30,34) DLUFEWWXNRQTMO-UHFFFAOYSA-N 265874 US9718790, I-0650 P2X purinoceptor 3 Homo sapiens 20.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265874 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265874&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 135121017 377004746 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505437 CCOC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(CC(C)C)c(OC)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H31ClN4O5/c1-5-36-23(32)12-13-30-25(33)29-24(31(26(30)34)16-18-6-9-20(27)10-7-18)28-21-11-8-19(14-17(2)3)22(15-21)35-4/h6-11,15,17H,5,12-14,16H2,1-4H3,(H,28,29,33) FMBRJHLCFZBZDY-UHFFFAOYSA-N 265875 US9718790, I-1308 P2X purinoceptor 3 Homo sapiens 29.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265875 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265875&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945258 377004747 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505438 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(cc3)S(N)(=O)=O)cc2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C25H25N5O5S/c1-3-29-24(31)28-23(30(25(29)32)16-18-6-4-17(2)5-7-18)27-19-8-10-20(11-9-19)35-21-12-14-22(15-13-21)36(26,33)34/h4-15H,3,16H2,1-2H3,(H2,26,33,34)(H,27,28,31) ZNJJLMJYYGXTAK-UHFFFAOYSA-N 265876 US9718790, I-2032 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265876 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265876&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278628 377004748 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505439 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(c(=O)n1Cc1ccc(Cl)cc1)C(C)(C)C(O)=O InChI=1S/C23H24Cl2N4O5/c1-13(2)34-18-10-9-16(11-17(18)25)26-20-27-21(32)29(23(3,4)19(30)31)22(33)28(20)12-14-5-7-15(24)8-6-14/h5-11,13H,12H2,1-4H3,(H,30,31)(H,26,27,32) INFCVXVOGZBBJU-UHFFFAOYSA-N 265877 US9718790, I-0651 P2X purinoceptor 3 Homo sapiens 97.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265877 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265877&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020942 377004749 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505440 COC(=O)[C@H](C)[C@H](C)n1c(=O)[nH]\c(=N/c2cccc(c2)C(F)(F)F)n(Cc2ccc(C)cc2)c1=O 265878 US9718790, I-1309 P2X purinoceptor 3 Homo sapiens 21.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265878 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265878&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278184 377004750 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505441 CCn1c(=O)[nH]\c(=N/c2ccc(cc2)-n2cc(ccc2=O)C(=O)OC)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H22ClN5O5/c1-3-29-24(34)28-23(31(25(29)35)14-16-4-7-18(26)8-5-16)27-19-9-11-20(12-10-19)30-15-17(22(33)36-2)6-13-21(30)32/h4-13,15H,3,14H2,1-2H3,(H,27,28,34) NRDWVVXMARKCNI-UHFFFAOYSA-N 265879 US9718790, I-2033 P2X purinoceptor 3 Homo sapiens 622 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265879 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265879&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278217 377004751 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505442 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n(CCN\C(Oc2ccccc2)=N/C#N)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C29H27ClFN7O4/c1-19(2)41-25-13-12-22(16-24(25)31)35-26-36-28(39)37(29(40)38(26)17-20-8-10-21(30)11-9-20)15-14-33-27(34-18-32)42-23-6-4-3-5-7-23/h3-13,16,19H,14-15,17H2,1-2H3,(H,33,34)(H,35,36,39) NVLBJYGKRDGMAM-UHFFFAOYSA-N 265880 US9718790, I-0652 P2X purinoceptor 3 Homo sapiens 102 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265880&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 86689100 377004752 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505443 COC(=O)[C@@H](C)[C@@H](C)n1c(=O)[nH]\c(=N/c2ccc(OC(C)C)cc2)n(Cc2ccc(C)cc2)c1=O 265881 US9718790, I-1310 P2X purinoceptor 3 Homo sapiens 66.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265881 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265881&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945106 377004753 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505444 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(c3)C(O)=O)cc2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C26H24N4O5/c1-3-29-25(33)28-24(30(26(29)34)16-18-9-7-17(2)8-10-18)27-20-11-13-21(14-12-20)35-22-6-4-5-19(15-22)23(31)32/h4-15H,3,16H2,1-2H3,(H,31,32)(H,27,28,33) HSUAPQVDWKQWKQ-UHFFFAOYSA-N 265882 US9718790, I-2034 P2X purinoceptor 3 Homo sapiens 9.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265882 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265882&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945483 377004754 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505445 CNC(NCCn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O)=NC#N InChI=1S/C24H26ClFN8O3/c1-15(2)37-20-9-8-18(12-19(20)26)31-22-32-23(35)33(11-10-29-21(28-3)30-14-27)24(36)34(22)13-16-4-6-17(25)7-5-16/h4-9,12,15H,10-11,13H2,1-3H3,(H2,28,29,30)(H,31,32,35) ONEPNZMTKCPMKB-UHFFFAOYSA-N 265883 US9718790, I-0653 P2X purinoceptor 3 Homo sapiens 37.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265883 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265883&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 86689099 377004755 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505446 COC(=O)[C@@H](C)[C@@H](C)n1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(F)c2)n(Cc2ccc(C)cc2)c1=O 265884 US9718790, I-1311 P2X purinoceptor 3 Homo sapiens 23.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265884 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265884&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020869 377004756 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505447 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(cc3)C(O)=O)cc2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C26H24N4O5/c1-3-29-25(33)28-24(30(26(29)34)16-18-6-4-17(2)5-7-18)27-20-10-14-22(15-11-20)35-21-12-8-19(9-13-21)23(31)32/h4-15H,3,16H2,1-2H3,(H,31,32)(H,27,28,33) IGSCEBOSVAPPNN-UHFFFAOYSA-N 265885 US9718790, I-2035 P2X purinoceptor 3 Homo sapiens 22.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265885 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265885&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020181 377004757 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505448 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n(CCS(O)(=O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C21H22ClFN4O6S/c1-13(2)33-18-8-7-16(11-17(18)23)24-19-25-20(28)26(9-10-34(30,31)32)21(29)27(19)12-14-3-5-15(22)6-4-14/h3-8,11,13H,9-10,12H2,1-2H3,(H,24,25,28)(H,30,31,32) RZHOYCJKHWEMSL-UHFFFAOYSA-N 265886 US9718790, I-0654 P2X purinoceptor 3 Homo sapiens 26.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265886 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265886&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 86689084 377004758 C15521 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505449 COC(=O)[C@@H](C)[C@@H](C)n1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(C)c2)n(Cc2ccc(C)cc2)c1=O 265887 US9718790, I-1312 P2X purinoceptor 3 Homo sapiens 45.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265887 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265887&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278239 377004759 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505450 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccnc(c3)C(O)=O)cc2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C25H23N5O5/c1-3-29-24(33)28-23(30(25(29)34)15-17-6-4-16(2)5-7-17)27-18-8-10-19(11-9-18)35-20-12-13-26-21(14-20)22(31)32/h4-14H,3,15H2,1-2H3,(H,31,32)(H,27,28,33) MQGBKGMZJBLJPZ-UHFFFAOYSA-N 265888 US9718790, I-2036 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265888 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265888&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019791 377004760 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505451 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(OC(F)F)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O 265889 US9718790, I-0655 P2X purinoceptor 3 Homo sapiens 67.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265889 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265889&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020943 377004761 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505452 CCCOc1ccc(cc1)\N=c1/[nH]c(=O)n([C@H](C)[C@H](C)C(=O)OC)c(=O)n1Cc1ccc(C)cc1 265890 US9718790, I-1313 P2X purinoceptor 3 Homo sapiens 62.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265890 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265890&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020877 377004762 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505453 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccsc3C(=O)OC)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H21ClN4O5S/c1-3-28-23(31)27-22(29(24(28)32)14-15-4-6-16(25)7-5-15)26-17-8-10-18(11-9-17)34-19-12-13-35-20(19)21(30)33-2/h4-13H,3,14H2,1-2H3,(H,26,27,31) RDBYHYLCVQJSQJ-UHFFFAOYSA-N 265891 US9718790, I-2037 P2X purinoceptor 3 Homo sapiens 340 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265891 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265891&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021007 377004763 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505454 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(COC(C)C)cc2)n(Cc2ccc(Cl)cc2)c1=O 265892 US9718790, I-0656 P2X purinoceptor 3 Homo sapiens 100.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265892 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265892&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278459 377004764 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505455 COC(=O)[C@@H](C)[C@@H](C)n1c(=O)[nH]\c(=N/c2ccc(OCC3CC3)cc2)n(Cc2ccc(C)cc2)c1=O 265893 US9718790, I-1314 P2X purinoceptor 3 Homo sapiens 59.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265893 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265893&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020879 377004765 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505456 Cc1[nH]c2ccc(cc2c1C)\N=c1/[nH]c(=O)n(CCOC2CCCCO2)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C27H28ClN5O4/c1-17-18(2)29-23-11-10-21(15-22(17)23)30-25-31-26(34)32(12-14-37-24-5-3-4-13-36-24)27(35)33(25)16-19-6-8-20(28)9-7-19/h6-11,15,24H,3-5,12-14,16H2,1-2H3/b30-21+ KNDGQFSAFGMTLW-MWAVMZGNSA-N 265894 US9718790, I-2038 P2X purinoceptor 3 Homo sapiens 13.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265894 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265894&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021004 377004766 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505457 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(CCO)cc2)n(Cc2ccc(Cl)cc2)c1=O 265895 US9718790, I-0657 P2X purinoceptor 3 Homo sapiens 471 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265895 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265895&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019761 377004767 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505458 COC(=O)[C@@H](C)[C@@H](C)n1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O 265896 US9718790, I-1315 P2X purinoceptor 3 Homo sapiens 40.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265896 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265896&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278240 377004768 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505459 Cc1[nH]c2ccc(cc2c1C)\N=c1/[nH]c(=O)n(C[C@H]2COC(C)(C)O2)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C26H26ClN5O4/c1-15-16(2)28-22-10-9-19(11-21(15)22)29-23-30-24(33)32(13-20-14-35-26(3,4)36-20)25(34)31(23)12-17-5-7-18(27)8-6-17/h5-11,20H,12-14H2,1-4H3/b29-19+/t20-/m0/s1 WUMBMURXPKNUOH-ZUSSYJGPSA-N 265897 US9718790, I-2039 P2X purinoceptor 3 Homo sapiens 9.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265897 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265897&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021036 377004769 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505460 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(OC(F)F)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 265898 US9718790, I-0658 P2X purinoceptor 3 Homo sapiens 109 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265898 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265898&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278460 377004770 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505461 COC(=O)[C@@H](C)[C@@H](C)n1c(=O)[nH]\c(=N/c2ccc(OCC3CC3)cc2)n(Cc2ccc(Cl)cc2)c1=O 265899 US9718790, I-1316 P2X purinoceptor 3 Homo sapiens 54.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265899 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265899&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019766 377004771 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505462 Clc1ccc(Cn2c(=O)n(CCOC3CCCCO3)c(=O)[nH]\c2=N/c2ccc(cc2)-n2ccccc2=O)cc1 265900 US9718790, I-2040 P2X purinoceptor 3 Homo sapiens 23.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265900 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265900&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021010 377004772 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505463 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n(CCNC(N)=N)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C22H25ClFN7O3/c1-13(2)34-18-8-7-16(11-17(18)24)28-20-29-21(32)30(10-9-27-19(25)26)22(33)31(20)12-14-3-5-15(23)6-4-14/h3-8,11,13H,9-10,12H2,1-2H3,(H4,25,26,27)(H,28,29,32) PVUZQIVHVORYOP-UHFFFAOYSA-N 265901 US9718790, I-0659 P2X purinoceptor 3 Homo sapiens 134 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265901 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265901&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019753 377004773 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505464 COC(=O)[C@@H](C)[C@@H](C)n1c(=O)[nH]\c(=N/c2cccc(c2)C(F)(F)F)n(Cc2ccc(Cl)cc2)c1=O 265902 US9718790, I-1317 P2X purinoceptor 3 Homo sapiens 105 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265902 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265902&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278330 377004774 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505465 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccsc3C(O)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H19ClN4O5S/c1-2-27-22(31)26-21(28(23(27)32)13-14-3-5-15(24)6-4-14)25-16-7-9-17(10-8-16)33-18-11-12-34-19(18)20(29)30/h3-12H,2,13H2,1H3,(H,29,30)(H,25,26,31) JEGHHKRKBNOHQM-UHFFFAOYSA-N 265903 US9718790, I-2041 P2X purinoceptor 3 Homo sapiens 109 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265903 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265903&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019846 377004775 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505466 COC(=O)Cn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(Cl)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C22H22Cl2N4O5/c1-13(2)33-18-9-8-16(10-17(18)24)25-20-26-21(30)28(12-19(29)32-3)22(31)27(20)11-14-4-6-15(23)7-5-14/h4-10,13H,11-12H2,1-3H3,(H,25,26,30) VGALIJZIQDQKQF-UHFFFAOYSA-N 265904 US9718790, I-0660 P2X purinoceptor 3 Homo sapiens 11.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265904 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265904&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019728 377004776 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505467 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc3ncccc3c2)n(Cc2ccc(Cl)cc2)c1=O 265905 US9718790, I-1318 P2X purinoceptor 3 Homo sapiens 544 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265905 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265905&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278185 377004777 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505468 Cc1[nH]c2ccc(cc2c1C)\N=c1/[nH]c(=O)n(CCO)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C22H22ClN5O3/c1-13-14(2)24-19-8-7-17(11-18(13)19)25-20-26-21(30)27(9-10-29)22(31)28(20)12-15-3-5-16(23)6-4-15/h3-8,11,24,29H,9-10,12H2,1-2H3,(H,25,26,30) AGLODUSAGCGDGY-UHFFFAOYSA-N 265906 US9718790, I-2042 P2X purinoceptor 3 Homo sapiens 23.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265906 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265906&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019847 377004778 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505469 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n(C[C@@H]2CN([C@@H](C)c3ccccc3)C(=O)C2)c(=O)n1Cc1ccc(Cl)cc1 265907 US9718790, I-0661 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265907 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265907&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020756 377004779 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505470 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc3nc(C)c(C)nc3c2)n(Cc2ccc(Cl)cc2)c1=O 265908 US9718790, I-1320 P2X purinoceptor 3 Homo sapiens 365 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265908 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265908&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278502 377004780 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505471 Cc1[nH]c2ccc(cc2c1C)\N=c1/[nH]c(=O)n(C[C@H](O)CO)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C23H22ClN5O4/c1-13-14(2)25-20-8-7-17(9-19(13)20)26-21-27-22(32)29(11-18(31)12-30)23(33)28(21)10-15-3-5-16(24)6-4-15/h3-9,18,30-31H,10-12H2,1-2H3/b26-17+/t18-/m0/s1 GGUHUBSNFDCIJX-WYZSWBMLSA-N 265909 US9718790, I-2043 P2X purinoceptor 3 Homo sapiens 9.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265909 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265909&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019995 377004781 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505472 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n(C[C@H]2CN([C@H](C)c3ccccc3)C(=O)C2)c(=O)n1Cc1ccc(Cl)cc1 265910 US9718790, I-0662 P2X purinoceptor 3 Homo sapiens 22.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265910 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265910&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020755 377004782 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505473 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc3nc(C)sc3c2)n(Cc2ccc(Cl)cc2)c1=O 265911 US9718790, I-1321 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265911 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265911&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020241 377004783 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505474 OCCn1c(=O)[nH]\c(=N/c2ccc(cc2)-n2ccccc2=O)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H20ClN5O4/c24-17-6-4-16(5-7-17)15-29-21(26-22(32)28(13-14-30)23(29)33)25-18-8-10-19(11-9-18)27-12-2-1-3-20(27)31/h1-12,30H,13-15H2,(H,25,26,32) IRVSXRNGKLDXSU-UHFFFAOYSA-N 265912 US9718790, I-2044 P2X purinoceptor 3 Homo sapiens 125 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265912 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265912&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020019 377004784 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505475 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(CC(=O)NC2CCOCC2)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C26H29Cl2N5O5/c1-16(2)38-22-8-7-20(13-21(22)28)30-24-31-25(35)33(15-23(34)29-19-9-11-37-12-10-19)26(36)32(24)14-17-3-5-18(27)6-4-17/h3-8,13,16,19H,9-12,14-15H2,1-2H3,(H,29,34)(H,30,31,35) MDPSSQDNTIEGMT-UHFFFAOYSA-N 265913 US9718790, I-0663 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265913 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265913&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020744 377004785 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505476 COC(=O)[C@H](C)[C@H](C)n1c(=O)[nH]\c(=N/c2ccc3nc(C)ccc3c2)n(Cc2ccc(Cl)cc2)c1=O 265914 US9718790, I-1322 P2X purinoceptor 3 Homo sapiens 20.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265914 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265914&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020225 377004786 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505477 Cc1ccc(Cn2\c(=N\c3ccc(Cl)cc3)[nH]c(=O)n(CCC(O)=O)c2=O)cc1 InChI=1S/C20H19ClN4O4/c1-13-2-4-14(5-3-13)12-25-18(22-16-8-6-15(21)7-9-16)23-19(28)24(20(25)29)11-10-17(26)27/h2-9H,10-12H2,1H3,(H,26,27)(H,22,23,28) MJQUREYMPPMGOS-UHFFFAOYSA-N 265915 US9718790, I-2045 P2X purinoceptor 3 Homo sapiens 975 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265915 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265915&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019968 377004787 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505478 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(CC(=O)NCC2CCOCC2)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C27H31Cl2N5O5/c1-17(2)39-23-8-7-21(13-22(23)29)31-25-32-26(36)34(16-24(35)30-14-18-9-11-38-12-10-18)27(37)33(25)15-19-3-5-20(28)6-4-19/h3-8,13,17-18H,9-12,14-16H2,1-2H3,(H,30,35)(H,31,32,36) NDYQZAAHXOOVBX-UHFFFAOYSA-N 265916 US9718790, I-0664 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265916 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265916&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020743 377004788 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505479 COC(=O)[C@H](C)[C@H](C)n1c(=O)[nH]\c(=N/c2ccc3oc(C)cc3c2)n(Cc2ccc(Cl)cc2)c1=O 265917 US9718790, I-1323 P2X purinoceptor 3 Homo sapiens 33.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265917 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265917&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278186 377004789 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505480 Cc1ccc(Cn2\c(=N\c3cccc(Cl)c3)[nH]c(=O)n(CCC(O)=O)c2=O)cc1 InChI=1S/C20H19ClN4O4/c1-13-5-7-14(8-6-13)12-25-18(22-16-4-2-3-15(21)11-16)23-19(28)24(20(25)29)10-9-17(26)27/h2-8,11H,9-10,12H2,1H3,(H,26,27)(H,22,23,28) BELCNDCUHKZZKP-UHFFFAOYSA-N 265918 US9718790, I-2047 P2X purinoceptor 3 Homo sapiens 384 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265918 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265918&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019834 377004790 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505481 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(CC(=O)NC(CO)CO)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C24H27Cl2N5O6/c1-14(2)37-20-8-7-17(9-19(20)26)28-22-29-23(35)31(11-21(34)27-18(12-32)13-33)24(36)30(22)10-15-3-5-16(25)6-4-15/h3-9,14,18,32-33H,10-13H2,1-2H3,(H,27,34)(H,28,29,35) ADBJOTZZPRPXCY-UHFFFAOYSA-N 265919 US9718790, I-0665 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265919 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265919&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020758 377004791 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505482 COC(=O)[C@H](C)[C@H](C)n1c(=O)[nH]\c(=N/c2ccc3nc(C)ccc3c2)n(Cc2ccc(C)cc2)c1=O 265920 US9718790, I-1324 P2X purinoceptor 3 Homo sapiens 9.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265920 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265920&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020242 377004792 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505483 CC(C)Oc1ccc(\N=c2/[nH]c(=O)n(CCC(O)=O)c(=O)n2Cc2ccc(C)cc2)c(C)c1 InChI=1S/C24H28N4O5/c1-15(2)33-19-9-10-20(17(4)13-19)25-22-26-23(31)27(12-11-21(29)30)24(32)28(22)14-18-7-5-16(3)6-8-18/h5-10,13,15H,11-12,14H2,1-4H3,(H,29,30)(H,25,26,31) JREBZPSJQCPSRQ-UHFFFAOYSA-N 265921 US9718790, I-2048 P2X purinoceptor 3 Homo sapiens 491 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265921 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265921&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945353 377004793 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505484 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(CC(=O)NCCC2CCOCC2)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C28H33Cl2N5O5/c1-18(2)40-24-8-7-22(15-23(24)30)32-26-33-27(37)35(17-25(36)31-12-9-19-10-13-39-14-11-19)28(38)34(26)16-20-3-5-21(29)6-4-20/h3-8,15,18-19H,9-14,16-17H2,1-2H3,(H,31,36)(H,32,33,37) XILHDCIQINYFPI-UHFFFAOYSA-N 265922 US9718790, I-0666 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265922 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265922&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020959 377004794 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505485 COC(=O)[C@H](C)[C@H](C)n1c(=O)[nH]\c(=N/c2ccc3oc(C)cc3c2)n(Cc2ccc(C)cc2)c1=O 265923 US9718790, I-1325 P2X purinoceptor 3 Homo sapiens 28.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265923 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265923&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945387 377004795 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505486 CC(C)Oc1ccc(\N=c2/[nH]c(=O)n(CCC(O)=O)c(=O)n2Cc2ccc(C)cc2)c(F)c1 InChI=1S/C23H25FN4O5/c1-14(2)33-17-8-9-19(18(24)12-17)25-21-26-22(31)27(11-10-20(29)30)23(32)28(21)13-16-6-4-15(3)5-7-16/h4-9,12,14H,10-11,13H2,1-3H3,(H,29,30)(H,25,26,31) LZZOFOPLVHHARL-UHFFFAOYSA-N 265924 US9718790, I-2049 P2X purinoceptor 3 Homo sapiens 85.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265924 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265924&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945472 377004796 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505487 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(CC(=O)OCC2CCOCC2)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C27H30Cl2N4O6/c1-17(2)39-23-8-7-21(13-22(23)29)30-25-31-26(35)33(15-24(34)38-16-19-9-11-37-12-10-19)27(36)32(25)14-18-3-5-20(28)6-4-18/h3-8,13,17,19H,9-12,14-16H2,1-2H3,(H,30,31,35) KEZMGQXSPYPROE-UHFFFAOYSA-N 265925 US9718790, I-0667 P2X purinoceptor 3 Homo sapiens 20.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265925 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265925&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020933 377004797 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505488 CCc1nc2ccc(cc2o1)\N=c1/[nH]c(=O)n(C[C@H](C)C(=O)OC)c(=O)n1Cc1ccc(Cl)cc1 265926 US9718790, I-1326 P2X purinoceptor 3 Homo sapiens 217 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265926 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265926&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278187 377004798 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505489 CCOc1ccc(\N=c2/[nH]c(=O)n(CCC(O)=O)c(=O)n2Cc2ccc(C)cc2)c(F)c1F InChI=1S/C22H22F2N4O5/c1-3-33-16-9-8-15(18(23)19(16)24)25-20-26-21(31)27(11-10-17(29)30)22(32)28(20)12-14-6-4-13(2)5-7-14/h4-9H,3,10-12H2,1-2H3,(H,29,30)(H,25,26,31) SPYONRIVRFZQEF-UHFFFAOYSA-N 265927 US9718790, I-2052 P2X purinoceptor 3 Homo sapiens 68.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265927 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265927&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945680 377004799 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505490 CC(C)OCc1ccc(cc1)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 265928 US9718790, I-0669 P2X purinoceptor 3 Homo sapiens 193 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265928 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265928&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020936 377004800 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505491 CCCc1nc2ccc(cc2o1)\N=c1/[nH]c(=O)n(C[C@H](C)C(=O)OC)c(=O)n1Cc1ccc(Cl)cc1 265929 US9718790, I-1327 P2X purinoceptor 3 Homo sapiens 73.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265929 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265929&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278331 377004801 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505598 CCCOc1ccc(cc1C)\N=c1/[nH]c(=O)n(C[C@H](C)C(=O)OC)c(=O)n1Cc1ccc(Cl)cc1 266036 US9718790, I-0707 P2X purinoceptor 3 Homo sapiens 21.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266036 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266036&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020958 377004908 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505599 COC(=O)[C@H](C)[C@H](C)n1c(=O)[nH]\c(=N/c2ccc(CC(C)C)c(OC)c2)n(Cc2ccc(C)cc2)c1=O 266037 US9718790, I-1364 P2X purinoceptor 3 Homo sapiens 43.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266037 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266037&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019769 377004909 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505600 Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cncc(c3)C(O)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H18ClN5O5/c1-28-22(32)27-21(29(23(28)33)13-14-2-4-16(24)5-3-14)26-17-6-8-18(9-7-17)34-19-10-15(20(30)31)11-25-12-19/h2-12H,13H2,1H3,(H,30,31)(H,26,27,32) VSYQHRDSMDCEHP-UHFFFAOYSA-N 266038 US9718790, I-2103 P2X purinoceptor 3 Homo sapiens 20.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266038 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266038&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020193 377004910 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505601 CC(C)Oc1ccc(cc1C)\N=c1/[nH]c(=O)n([C@H]2C[C@H](N(C2)C(=O)OC(C)(C)C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 266039 US9718790, I-0708 P2X purinoceptor 3 Homo sapiens 966 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266039 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266039&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020961 377004911 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505602 CCCc1ccc(cc1OC)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(C)cc1 266040 US9718790, I-1365 P2X purinoceptor 3 Homo sapiens 94.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266040 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266040&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019964 377004912 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505603 CNC(=O)c1cc(Oc2ccc(cc2)\N=c2/[nH]c(=O)[nH]c(=O)n2Cc2ccc(C)cc2)ccn1 InChI=1S/C24H22N6O4/c1-15-3-5-16(6-4-15)14-30-22(28-23(32)29-24(30)33)27-17-7-9-18(10-8-17)34-19-11-12-26-20(13-19)21(31)25-2/h3-13H,14H2,1-2H3,(H,25,31)(H2,27,28,29,32,33) WHVYHZBJJFUTKM-UHFFFAOYSA-N 266041 US9718790, I-2104 P2X purinoceptor 3 Homo sapiens 40.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266041 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266041&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020294 377004913 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505604 CC(C)Oc1ccc(cc1C)\N=c1/[nH]c(=O)n(C[C@H]2COC(C)(C)O2)c(=O)n1Cc1ccc(Cl)cc1 266042 US9718790, I-0709 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266042 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266042&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020963 377004914 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505605 COc1cc(ccc1CC(C)C)\N=c1/[nH]c(=O)n([C@@H](C)[C@@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 266043 US9718790, I-1366 P2X purinoceptor 3 Homo sapiens 20.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266043 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266043&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020289 377004915 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505606 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(nc3)C(=O)OC)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H22ClN5O5/c1-3-30-24(33)29-23(31(25(30)34)15-16-4-6-17(26)7-5-16)28-18-8-10-19(11-9-18)36-20-12-13-21(27-14-20)22(32)35-2/h4-14H,3,15H2,1-2H3,(H,28,29,33) MTDOMVRCZIRXLB-UHFFFAOYSA-N 266044 US9718790, I-2105 P2X purinoceptor 3 Homo sapiens 1.000 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266044 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266044&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020227 377004916 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505607 CC(C)Oc1ccc(cc1C)\N=c1/[nH]c(=O)n(Cc2ccc(o2)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C26H25ClN4O6/c1-15(2)36-21-10-8-19(12-16(21)3)28-24-29-25(34)31(14-20-9-11-22(37-20)23(32)33)26(35)30(24)13-17-4-6-18(27)7-5-17/h4-12,15H,13-14H2,1-3H3,(H,32,33)(H,28,29,34) APPYDFABGUFLSP-UHFFFAOYSA-N 266045 US9718790, I-0710 P2X purinoceptor 3 Homo sapiens 19.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266045 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266045&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020955 377004917 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505608 COc1cc(ccc1CC(C)C)\N=c1/[nH]c(=O)n([C@@H](C)[C@@H](C)C(O)=O)c(=O)n1Cc1ccc(C)cc1 266046 US9718790, I-1367 P2X purinoceptor 3 Homo sapiens 14.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266046 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266046&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278324 377004918 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505609 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(nc3)C(=O)OC)cc2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C26H25N5O5/c1-4-30-25(33)29-24(31(26(30)34)16-18-7-5-17(2)6-8-18)28-19-9-11-20(12-10-19)36-21-13-14-22(27-15-21)23(32)35-3/h5-15H,4,16H2,1-3H3,(H,28,29,33) MKTKYMXCCBJQQA-UHFFFAOYSA-N 266047 US9718790, I-2106 P2X purinoceptor 3 Homo sapiens 2.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266047 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266047&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021194 377004919 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505610 CCCOc1ccc(cc1C)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 266048 US9718790, I-0711 P2X purinoceptor 3 Homo sapiens 40.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266048 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266048&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019705 377004920 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505611 COC(=O)CCCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(C)nc3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C27H26ClN5O5/c1-18-5-12-23(16-29-18)38-22-13-10-21(11-14-22)30-25-31-26(35)32(15-3-4-24(34)37-2)27(36)33(25)17-19-6-8-20(28)9-7-19/h5-14,16H,3-4,15,17H2,1-2H3,(H,30,31,35) WPIHEJYXPFWUKB-UHFFFAOYSA-N 266049 US9718790, I-1368 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266049 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266049&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020261 377004921 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505612 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cc(on3)C(N)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C22H19ClN6O5/c1-2-28-21(31)26-20(29(22(28)32)12-13-3-5-14(23)6-4-13)25-15-7-9-16(10-8-15)33-18-11-17(19(24)30)34-27-18/h3-11H,2,12H2,1H3,(H2,24,30)(H,25,26,31) XREPSXSYYYCFOE-UHFFFAOYSA-N 266050 US9718790, I-2107 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266050 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266050&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945369 377004922 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505613 CC(C)Oc1ccc(cc1C)\N=c1/[nH]c(=O)n(Cc2cccn(CCOC3CCCCO3)c2=O)c(=O)n1Cc1ccc(Cl)cc1 266051 US9718790, I-0712 P2X purinoceptor 3 Homo sapiens 25.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266051 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266051&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019826 377004923 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505614 CCOC(=O)CCCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(C)nc3)cc2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C29H31N5O5/c1-4-38-26(35)6-5-17-33-28(36)32-27(34(29(33)37)19-22-10-7-20(2)8-11-22)31-23-12-15-24(16-13-23)39-25-14-9-21(3)30-18-25/h7-16,18H,4-6,17,19H2,1-3H3,(H,31,32,36) FVTOVRQCANUWMN-UHFFFAOYSA-N 266052 US9718790, I-1369 P2X purinoceptor 3 Homo sapiens 3.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266052 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266052&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020263 377004924 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505615 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3nccc(O)n3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C22H19ClN6O4/c1-2-28-21(31)27-19(29(22(28)32)13-14-3-5-15(23)6-4-14)25-16-7-9-17(10-8-16)33-20-24-12-11-18(30)26-20/h3-12H,2,13H2,1H3,(H,24,26,30)(H,25,27,31) CZVMGUWCGZLBLL-UHFFFAOYSA-N 266053 US9718790, I-2108 P2X purinoceptor 3 Homo sapiens 26.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266053 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266053&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945503 377004925 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505616 CC(C)Oc1ccc(cc1C)\N=c1/[nH]c(=O)n(Cc2cccn(CCO)c2=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C28H30ClN5O5/c1-18(2)39-24-11-10-23(15-19(24)3)30-26-31-27(37)34(17-21-5-4-12-32(13-14-35)25(21)36)28(38)33(26)16-20-6-8-22(29)9-7-20/h4-12,15,18,35H,13-14,16-17H2,1-3H3,(H,30,31,37) MVAUKKOJCCZBEB-UHFFFAOYSA-N 266054 US9718790, I-0713 P2X purinoceptor 3 Homo sapiens 16.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266054 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266054&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019706 377004926 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505617 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(CC(C)C)c(Cl)c2)n(Cc2ccc(Cl)cc2)c1=O 266055 US9718790, I-1370 P2X purinoceptor 3 Homo sapiens 19.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266055 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266055&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019918 377004927 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505618 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n(CCN(CCO)C(=O)OC(C)(C)C)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C28H35ClFN5O6/c1-18(2)40-23-11-10-21(16-22(23)30)31-24-32-25(37)34(13-12-33(14-15-36)27(39)41-28(3,4)5)26(38)35(24)17-19-6-8-20(29)9-7-19/h6-11,16,18,36H,12-15,17H2,1-5H3,(H,31,32,37) LAERZAHGYKTUPV-UHFFFAOYSA-N 266056 US9718790, I-2109 P2X purinoceptor 3 Homo sapiens 11.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266056 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266056&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021143 377004928 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505619 CC(C)Oc1ccc(cc1C)\N=c1/[nH]c(=O)n(Cc2cccnc2OCCOC2CCCCO2)c(=O)n1Cc1ccc(Cl)cc1 266057 US9718790, I-0714 P2X purinoceptor 3 Homo sapiens 30.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266057 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266057&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945014 377004929 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505620 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(CC(C)C)c(Cl)c2)n(Cc2ccc(C)cc2)c1=O 266058 US9718790, I-1371 P2X purinoceptor 3 Homo sapiens 9.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266058 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266058&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020106 377004930 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505621 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccnc(c3)C(=O)NC)cc2)n(Cc2ccc(F)cc2)c1=O InChI=1S/C25H23FN6O4/c1-3-31-24(34)30-23(32(25(31)35)15-16-4-6-17(26)7-5-16)29-18-8-10-19(11-9-18)36-20-12-13-28-21(14-20)22(33)27-2/h4-14H,3,15H2,1-2H3,(H,27,33)(H,29,30,34) ZEELQYXMOJWWRF-UHFFFAOYSA-N 266059 US9718790, I-2110 P2X purinoceptor 3 Homo sapiens 12.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266059 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266059&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945373 377004931 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505622 CC(C)Oc1ccc(cc1C)\N=c1/[nH]c(=O)n(Cc2cccnc2OCCO)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C28H30ClN5O5/c1-18(2)39-24-11-10-23(15-19(24)3)31-26-32-27(36)34(17-21-5-4-12-30-25(21)38-14-13-35)28(37)33(26)16-20-6-8-22(29)9-7-20/h4-12,15,18,35H,13-14,16-17H2,1-3H3,(H,31,32,36) FSOOMQKGSSGSTO-UHFFFAOYSA-N 266060 US9718790, I-0715 P2X purinoceptor 3 Homo sapiens 13.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266060 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266060&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019827 377004932 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505623 CC(C)Cc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 266061 US9718790, I-1372 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266061 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266061&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020138 377004933 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505624 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cncc(c3)C(=O)OC)cc2)n(Cc2ccc(F)cc2)c1=O InChI=1S/C25H22FN5O5/c1-3-30-24(33)29-23(31(25(30)34)15-16-4-6-18(26)7-5-16)28-19-8-10-20(11-9-19)36-21-12-17(13-27-14-21)22(32)35-2/h4-14H,3,15H2,1-2H3,(H,28,29,33) LWKAOVUHNQYZHP-UHFFFAOYSA-N 266062 US9718790, I-2111 P2X purinoceptor 3 Homo sapiens 44.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266062 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266062&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278318 377004934 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505625 CC(C)Oc1ccc(cc1C)\N=c1/[nH]c(=O)n([C@@H]2CN[C@@H](C2)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 266063 US9718790, I-0716 P2X purinoceptor 3 Homo sapiens 102 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266063 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266063&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020774 377004935 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505626 CC(C)Cc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(C)cc1 266064 US9718790, I-1373 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266064 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266064&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020108 377004936 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505627 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cncc(c3)C(O)=O)cc2)n(Cc2ccc(F)cc2)c1=O InChI=1S/C24H20FN5O5/c1-2-29-23(33)28-22(30(24(29)34)14-15-3-5-17(25)6-4-15)27-18-7-9-19(10-8-18)35-20-11-16(21(31)32)12-26-13-20/h3-13H,2,14H2,1H3,(H,31,32)(H,27,28,33) JSRZCATZEQQSHY-UHFFFAOYSA-N 266065 US9718790, I-2112 P2X purinoceptor 3 Homo sapiens 47.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266065 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266065&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945378 377004937 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505628 CCOC(=O)[C@H](CCn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O)NC(=O)OC(C)(C)C 266066 US9718790, I-0717 P2X purinoceptor 3 Homo sapiens 21.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266066 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266066&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 86689112 377004938 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505629 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(C)nc3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(=O)CCC(O)=O 266067 US9718790, I-1374 P2X purinoceptor 3 Homo sapiens 17.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266067 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266067&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278335 377004939 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505630 COC(=O)c1cc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(CCOC3CCCCO3)c(=O)n2Cc2ccc(Cl)cc2)no1 266068 US9718790, I-2113 P2X purinoceptor 3 Homo sapiens 1.000 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266068 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266068&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278391 377004940 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505631 CCOC(=O)C1CC[C@@H](CC1)n1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O 266069 US9718790, I-0718 P2X purinoceptor 3 Homo sapiens 93.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266069 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266069&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020762 377004941 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505632 COC(=O)[C@H](C)[C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(C)nc3)cc2)n(Cc2ccc(Cl)cc2)c1=O 266070 US9718790, I-1375 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266070 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266070&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945143 377004942 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505633 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(CO)nc3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H22ClN5O4/c1-2-29-23(32)28-22(30(24(29)33)14-16-3-5-17(25)6-4-16)27-18-7-10-20(11-8-18)34-21-12-9-19(15-31)26-13-21/h3-13,31H,2,14-15H2,1H3,(H,27,28,32) MLXSNVIJYASMNZ-UHFFFAOYSA-N 266071 US9718790, I-2114 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266071 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266071&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945422 377004943 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505634 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(OCCO)cc2)n(Cc2ccc(Cl)cc2)c1=O 266072 US9718790, I-0719 P2X purinoceptor 3 Homo sapiens 115 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266072 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266072&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278162 377004944 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505635 COC(=O)[C@@H](C)[C@@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(C)nc3)cc2)n(Cc2ccc(Cl)cc2)c1=O 266073 US9718790, I-1376 P2X purinoceptor 3 Homo sapiens 15.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266073 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266073&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278578 377004945 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505636 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(nc3)C(O)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H20ClN5O5/c1-2-29-23(33)28-22(30(24(29)34)14-15-3-5-16(25)6-4-15)27-17-7-9-18(10-8-17)35-19-11-12-20(21(31)32)26-13-19/h3-13H,2,14H2,1H3,(H,31,32)(H,27,28,33) RTUAVHRECQKXHX-UHFFFAOYSA-N 266074 US9718790, I-2115 P2X purinoceptor 3 Homo sapiens 18.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266074 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266074&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020551 377004946 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505637 CNC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O 266075 US9718790, I-0721 P2X purinoceptor 3 Homo sapiens 13.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266075 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266075&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020953 377004947 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505638 COC(=O)[C@H](C)[C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3cccnc3)cc2)n(Cc2ccc(Cl)cc2)c1=O 266076 US9718790, I-1377 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266076 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266076&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278579 377004948 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505639 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(nc3)C(O)=O)cc2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C25H23N5O5/c1-3-29-24(33)28-23(30(25(29)34)15-17-6-4-16(2)5-7-17)27-18-8-10-19(11-9-18)35-20-12-13-21(22(31)32)26-14-20/h4-14H,3,15H2,1-2H3,(H,31,32)(H,27,28,33) HOVGEFRQWSQGIA-UHFFFAOYSA-N 266077 US9718790, I-2116 P2X purinoceptor 3 Homo sapiens 15.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266077 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266077&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945371 377004949 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505640 CC(C)Oc1ccc(cc1C)\N=c1/[nH]c(=O)n(C[C@H](O)CO)c(=O)n1Cc1ccc(Cl)cc1 266078 US9718790, I-0722 P2X purinoceptor 3 Homo sapiens 14.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266078 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266078&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020950 377004950 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505641 COC(=O)[C@H](C)[C@H](C)n1c(=O)[nH]\c(=N/c2ccc(OC3CCC3)cc2)n(Cc2ccc(Cl)cc2)c1=O 266079 US9718790, I-1378 P2X purinoceptor 3 Homo sapiens 12.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266079 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266079&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945519 377004951 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505642 OCCn1c(=O)[nH]\c(=N/c2ccc(Oc3cc(on3)C(O)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C22H18ClN5O7/c23-14-3-1-13(2-4-14)12-28-20(25-21(32)27(9-10-29)22(28)33)24-15-5-7-16(8-6-15)34-18-11-17(19(30)31)35-26-18/h1-8,11,29H,9-10,12H2,(H,30,31)(H,24,25,32) YNIDOQMIERRRQX-UHFFFAOYSA-N 266080 US9718790, I-2117 P2X purinoceptor 3 Homo sapiens 23.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266080 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266080&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021016 377004952 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505643 CC(C)Oc1ccc(cc1C)\N=c1/[nH]c(=O)n(C[C@H](C)C(=O)NCCO)c(=O)n1Cc1ccc(Cl)cc1 266081 US9718790, I-0723 P2X purinoceptor 3 Homo sapiens 24.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266081 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266081&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020951 377004953 C04080 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505644 COC(=O)[C@H](C)[C@H](C)n1c(=O)[nH]\c(=N/c2ccc(OC3CCC3)cc2)n(Cc2ccc(C)cc2)c1=O 266082 US9718790, I-1379 P2X purinoceptor 3 Homo sapiens 10.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266082 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266082&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019775 377004954 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505645 OCCn1c(=O)[nH]\c(=N/c2ccc(Oc3cc(CO)on3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C22H20ClN5O6/c23-15-3-1-14(2-4-15)12-28-20(25-21(31)27(9-10-29)22(28)32)24-16-5-7-17(8-6-16)33-19-11-18(13-30)34-26-19/h1-8,11,29-30H,9-10,12-13H2,(H,24,25,31) SLGNMDHAWUMYEE-UHFFFAOYSA-N 266083 US9718790, I-2118 P2X purinoceptor 3 Homo sapiens 35.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266083 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266083&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945362 377004955 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505646 COc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 266084 US9718790, I-0724 P2X purinoceptor 3 Homo sapiens 250 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266084 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266084&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020952 377004956 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505647 COC(=O)[C@H](C)[C@H](C)n1c(=O)[nH]\c(=N/c2ccc(cc2)N2CCCCC2)n(Cc2ccc(Cl)cc2)c1=O 266085 US9718790, I-1380 P2X purinoceptor 3 Homo sapiens 26.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266085 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266085&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019776 377004957 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505648 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(nc3)C(N)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H21ClN6O4/c1-2-30-23(33)29-22(31(24(30)34)14-15-3-5-16(25)6-4-15)28-17-7-9-18(10-8-17)35-19-11-12-20(21(26)32)27-13-19/h3-13H,2,14H2,1H3,(H2,26,32)(H,28,29,33) PNCHTQOOKMPVBP-UHFFFAOYSA-N 266086 US9718790, I-2119 P2X purinoceptor 3 Homo sapiens 1.000 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266086 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266086&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945372 377004958 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505649 CC(C)Oc1ccc(cc1C)\N=c1/[nH]c(=O)n(Cc2ccc[nH]c2=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C26H26ClN5O4/c1-16(2)36-22-11-10-21(13-17(22)3)29-24-30-25(34)32(15-19-5-4-12-28-23(19)33)26(35)31(24)14-18-6-8-20(27)9-7-18/h4-13,16H,14-15H2,1-3H3,(H,28,33)(H,29,30,34) IQSQJMULEFMEAE-UHFFFAOYSA-N 266087 US9718790, I-0725 P2X purinoceptor 3 Homo sapiens 14.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266087 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266087&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 135121019 377004959 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505650 COC(=O)[C@H](C)[C@H](C)n1c(=O)[nH]\c(=N/c2ccc(cc2)N2CCCCC2)n(Cc2ccc(C)cc2)c1=O 266088 US9718790, I-1381 P2X purinoceptor 3 Homo sapiens 20.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266088 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266088&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278580 377004960 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505651 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cncc(c3)C(N)=O)cc2)n(Cc2ccc(F)cc2)c1=O InChI=1S/C24H21FN6O4/c1-2-30-23(33)29-22(31(24(30)34)14-15-3-5-17(25)6-4-15)28-18-7-9-19(10-8-18)35-20-11-16(21(26)32)12-27-13-20/h3-13H,2,14H2,1H3,(H2,26,32)(H,28,29,33) SQYCHOPKEMDHGO-UHFFFAOYSA-N 266089 US9718790, I-2120 P2X purinoceptor 3 Homo sapiens 33.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266089 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266089&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021037 377004961 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505652 CC(C)Oc1ccc(cc1C)\N=c1/[nH]c(=O)n(C[C@H](C)C(=O)NCC(F)(F)F)c(=O)n1Cc1ccc(Cl)cc1 266090 US9718790, I-0726 P2X purinoceptor 3 Homo sapiens 16.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266090 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266090&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019551 377004962 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505653 CCc1nc2ccc(cc2o1)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 266091 US9718790, I-1382 P2X purinoceptor 3 Homo sapiens 257 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266091 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266091&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020415 377004963 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505654 Cc1ccc(Cn2c(=O)n(C)c(=O)[nH]\c2=N/c2ccc(Oc3cncc(c3)C(O)=O)cc2)cc1 InChI=1S/C24H21N5O5/c1-15-3-5-16(6-4-15)14-29-22(27-23(32)28(2)24(29)33)26-18-7-9-19(10-8-18)34-20-11-17(21(30)31)12-25-13-20/h3-13H,14H2,1-2H3,(H,30,31)(H,26,27,32) RTAJTANBTRXQFG-UHFFFAOYSA-N 266092 US9718790, I-2121 P2X purinoceptor 3 Homo sapiens 21.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266092 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266092&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021119 377004964 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505655 CC[C@@H](C)Oc1ccc(cc1)\N=c1/[nH]c(=O)n(C[C@H](C)C(=O)OC)c(=O)n1Cc1ccc(Cl)cc1 266093 US9718790, I-0727 P2X purinoceptor 3 Homo sapiens 12.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266093 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266093&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019526 377004965 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505656 CCCc1nc2ccc(cc2o1)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)O)c(=O)n1Cc1ccc(Cl)cc1 266094 US9718790, I-1384 P2X purinoceptor 3 Homo sapiens 50.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266094 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266094&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278191 377004966 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505657 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n(CCNCCO)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C23H27ClFN5O4/c1-15(2)34-20-8-7-18(13-19(20)25)27-21-28-22(32)29(11-9-26-10-12-31)23(33)30(21)14-16-3-5-17(24)6-4-16/h3-8,13,15,26,31H,9-12,14H2,1-2H3,(H,27,28,32) PVKBKNNYXDRXDZ-UHFFFAOYSA-N 266095 US9718790, I-2122 P2X purinoceptor 3 Homo sapiens 93.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266095 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266095&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945694 377004967 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505658 CC[C@H](C)Oc1ccc(cc1)\N=c1/[nH]c(=O)n(C[C@H](C)C(=O)OC)c(=O)n1Cc1ccc(Cl)cc1 266096 US9718790, I-0728 P2X purinoceptor 3 Homo sapiens 14.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266096 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266096&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019543 377004968 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505659 CC(C)COc1ccc(cc1)\N=c1/[nH]c(=O)n([C@@H](C)[C@@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 266097 US9718790, I-1386 P2X purinoceptor 3 Homo sapiens 28.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266097 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266097&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278249 377004969 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505660 CCOC(=O)CCCn1c(=O)[nH]\c(=N/c2ccc3nc(C)sc3c2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C25H27N5O4S/c1-4-34-22(31)6-5-13-29-24(32)28-23(27-19-11-12-20-21(14-19)35-17(3)26-20)30(25(29)33)15-18-9-7-16(2)8-10-18/h7-12,14H,4-6,13,15H2,1-3H3,(H,27,28,32) MIMOZTJQNBMPEC-UHFFFAOYSA-N 266098 US9718790, I-2123 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266098 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266098&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021132 377004970 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505661 CCOC(=O)C(\Cn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O)=N\OC InChI=1S/C26H30ClN5O6/c1-6-37-23(33)21(30-36-5)15-32-25(34)29-24(28-20-11-12-22(17(4)13-20)38-16(2)3)31(26(32)35)14-18-7-9-19(27)10-8-18/h7-13,16H,6,14-15H2,1-5H3,(H,28,29,34)/b30-21+ PYBAPHLAIIUCCV-MWAVMZGNSA-N 266099 US9718790, I-0729 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266099 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266099&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 88558733 377004971 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505662 CC(C)COc1ccc(cc1)\N=c1/[nH]c(=O)n([C@@H](C)[C@@H](C)C(O)=O)c(=O)n1Cc1ccc(C)cc1 266100 US9718790, I-1387 P2X purinoceptor 3 Homo sapiens 44.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266100 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266100&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945175 377004972 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505663 Cc1nc2ccc(cc2s1)\N=c1/[nH]c(=O)n(CCCC(O)=O)c(=O)n1Cc1ccc(C)cc1 InChI=1S/C23H23N5O4S/c1-14-5-7-16(8-6-14)13-28-21(25-17-9-10-18-19(12-17)33-15(2)24-18)26-22(31)27(23(28)32)11-3-4-20(29)30/h5-10,12H,3-4,11,13H2,1-2H3,(H,29,30)(H,25,26,31) QTNAQAZLNFHKDI-UHFFFAOYSA-N 266101 US9718790, I-2124 P2X purinoceptor 3 Homo sapiens 27.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266101 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266101&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021173 377004973 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505664 CC[C@H](C)Oc1ccc(cc1C)\N=c1/[nH]c(=O)n(C[C@H](C)C(=O)OC)c(=O)n1Cc1ccc(Cl)cc1 266102 US9718790, I-0730 P2X purinoceptor 3 Homo sapiens 23.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266102 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266102&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019527 377004974 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505665 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(C)nc3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 266103 US9718790, I-1388 P2X purinoceptor 3 Homo sapiens 9.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266103 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266103&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278250 377004975 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505666 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cncc(OC)n3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H21ClN6O4/c1-3-29-22(31)28-21(30(23(29)32)14-15-4-6-16(24)7-5-15)26-17-8-10-18(11-9-17)34-20-13-25-12-19(27-20)33-2/h4-13H,3,14H2,1-2H3,(H,26,28,31) GXPJQRLXFFBKMP-UHFFFAOYSA-N 266104 US9718790, I-2125 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266104 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266104&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021174 377004976 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505667 CC[C@@H](C)Oc1ccc(cc1C)\N=c1/[nH]c(=O)n(C[C@H](C)C(=O)OC)c(=O)n1Cc1ccc(Cl)cc1 266105 US9718790, I-0731 P2X purinoceptor 3 Homo sapiens 12.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266105 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266105&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020402 377004977 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505668 C[C@@H]([C@@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(C)nc3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 266106 US9718790, I-1389 P2X purinoceptor 3 Homo sapiens 12.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266106 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266106&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278325 377004978 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505669 Cc1ccc(Cn2\c(=N\c3ccc4n(C)c(=O)ccc4c3)[nH]c(=O)n(CCC(O)=O)c2=O)cc1 InChI=1S/C24H23N5O5/c1-15-3-5-16(6-4-15)14-29-22(26-23(33)28(24(29)34)12-11-21(31)32)25-18-8-9-19-17(13-18)7-10-20(30)27(19)2/h3-10,13H,11-12,14H2,1-2H3,(H,31,32)(H,25,26,33) HIYWCTSZMATUTJ-UHFFFAOYSA-N 266107 US9718790, I-2128 P2X purinoceptor 3 Homo sapiens 287 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266107 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266107&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945698 377004979 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505670 CC(C)Oc1ccc(cc1C)\N=c1/[nH]c(=O)n(CC[C@H](NC(=O)OC(C)(C)C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 266108 US9718790, I-0732 P2X purinoceptor 3 Homo sapiens 41.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266108 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266108&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 86689114 377004980 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505671 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3cccnc3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 266109 US9718790, I-1390 P2X purinoceptor 3 Homo sapiens 15.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266109 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266109&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278192 377004981 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505672 CCOc1ccc2cc(ccc2c1)\N=c1/[nH]c(=O)n(CCC(O)=O)c(=O)n1Cc1ccc(C)cc1 InChI=1S/C26H26N4O5/c1-3-35-22-11-9-19-14-21(10-8-20(19)15-22)27-24-28-25(33)29(13-12-23(31)32)26(34)30(24)16-18-6-4-17(2)5-7-18/h4-11,14-15H,3,12-13,16H2,1-2H3,(H,31,32)(H,27,28,33) CYMIFYFCMSIYSW-UHFFFAOYSA-N 266110 US9718790, I-2130 P2X purinoceptor 3 Homo sapiens 790 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266110 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266110&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019859 377004982 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505673 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(OCCO)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 266111 US9718790, I-0733 P2X purinoceptor 3 Homo sapiens 287 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266111 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266111&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020413 377004983 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505674 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc(OC3CCC3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 266112 US9718790, I-1391 P2X purinoceptor 3 Homo sapiens 16.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266112 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266112&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945149 377004984 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505675 Cc1ccc(Cn2\c(=N\c3ccc4[nH]c(=O)sc4c3)[nH]c(=O)n(CCC(O)=O)c2=O)cc1 InChI=1S/C21H19N5O5S/c1-12-2-4-13(5-3-12)11-26-18(24-19(29)25(21(26)31)9-8-17(27)28)22-14-6-7-15-16(10-14)32-20(30)23-15/h2-7,10H,8-9,11H2,1H3,(H,23,30)(H,27,28)(H,22,24,29) GFUGNDKOXMDSFU-UHFFFAOYSA-N 266113 US9718790, I-2133 P2X purinoceptor 3 Homo sapiens 182 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266113 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266113&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019740 377004985 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505676 CCOC(=O)C(\Cn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O)=N\OC InChI=1S/C25H27ClFN5O6/c1-5-37-22(33)20(30-36-4)14-32-24(34)29-23(28-18-10-11-21(19(27)12-18)38-15(2)3)31(25(32)35)13-16-6-8-17(26)9-7-16/h6-12,15H,5,13-14H2,1-4H3,(H,28,29,34)/b30-20+ YIGJBVSOWOYXIM-TWKHWXDSSA-N 266114 US9718790, I-0735 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266114 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266114&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 88558810 377004986 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505677 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc(OC3CCC3)cc2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 266115 US9718790, I-1392 P2X purinoceptor 3 Homo sapiens 18.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266115 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266115&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945168 377004987 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505678 COc1ccc2cc(ccc2n1)\N=c1/[nH]c(=O)n(CCC(O)=O)c(=O)n1Cc1ccc(C)cc1 InChI=1S/C24H23N5O5/c1-15-3-5-16(6-4-15)14-29-22(27-23(32)28(24(29)33)12-11-21(30)31)25-18-8-9-19-17(13-18)7-10-20(26-19)34-2/h3-10,13H,11-12,14H2,1-2H3,(H,30,31)(H,25,27,32) OBYJTKJIKRERSU-UHFFFAOYSA-N 266116 US9718790, I-2137 P2X purinoceptor 3 Homo sapiens 134 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266116 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266116&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021006 377004988 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505679 CC(C)Oc1ccc(cc1C)\N=c1/[nH]c(=O)n(CC[C@H](N)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 266117 US9718790, I-0736 P2X purinoceptor 3 Homo sapiens 131 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266117 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266117&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 86689116 377004989 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505680 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc(cc2)N2CCCCC2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 266118 US9718790, I-1393 P2X purinoceptor 3 Homo sapiens 35.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266118 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266118&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278581 377004990 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505681 CCn1c(=O)[nH]\c(=N/c2ccc(OC3CNC=C(C3)C(=O)OC)cc2)n(Cc2ccc(Cl)cc2)c1=O 266119 US9718790, I-2138 P2X purinoceptor 3 Homo sapiens 171 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266119 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266119&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021043 377004991 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505682 CO\N=C(/Cn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O InChI=1S/C23H23ClFN5O6/c1-13(2)36-19-9-8-16(10-17(19)25)26-21-27-22(33)30(12-18(20(31)32)28-35-3)23(34)29(21)11-14-4-6-15(24)7-5-14/h4-10,13H,11-12H2,1-3H3,(H,31,32)(H,26,27,33)/b28-18+ UBTPMHBDZWHOKQ-MTDXEUNCSA-N 266120 US9718790, I-0737 P2X purinoceptor 3 Homo sapiens 140 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266120 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266120&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 88558735 377004992 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505683 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc(cc2)N2CCCCC2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 266121 US9718790, I-1394 P2X purinoceptor 3 Homo sapiens 44.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266121 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266121&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278582 377004993 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505684 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(NC(C)=O)c3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H24ClN5O4/c1-3-31-25(34)30-24(32(26(31)35)16-18-7-9-19(27)10-8-18)29-20-11-13-22(14-12-20)36-23-6-4-5-21(15-23)28-17(2)33/h4-15H,3,16H2,1-2H3,(H,28,33)(H,29,30,34) JPELLAOIEKQASR-UHFFFAOYSA-N 266122 US9718790, I-2139 P2X purinoceptor 3 Homo sapiens 22.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266122 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266122&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020993 377004994 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505685 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(OCC(F)F)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O 266123 US9718790, I-0738 P2X purinoceptor 3 Homo sapiens 19.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266123 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266123&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 88558736 377004995 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505686 Cc1ccc(Cn2c(=O)n(CCCC(O)=O)c(=O)[nH]\c2=N/c2ccc(Oc3ccc(C)nc3)cc2)cc1 InChI=1S/C27H27N5O5/c1-18-5-8-20(9-6-18)17-32-25(30-26(35)31(27(32)36)15-3-4-24(33)34)29-21-10-13-22(14-11-21)37-23-12-7-19(2)28-16-23/h5-14,16H,3-4,15,17H2,1-2H3,(H,33,34)(H,29,30,35) FQEMVANGBBOIFZ-UHFFFAOYSA-N 266124 US9718790, I-1395 P2X purinoceptor 3 Homo sapiens 23.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266124 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266124&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945406 377004996 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505687 Cc1ccc(Cn2c(=O)[nH]c(=O)[nH]\c2=N/c2ccc(Oc3ccnc(c3)C(O)=O)cc2)cc1 InChI=1S/C23H19N5O5/c1-14-2-4-15(5-3-14)13-28-21(26-22(31)27-23(28)32)25-16-6-8-17(9-7-16)33-18-10-11-24-19(12-18)20(29)30/h2-12H,13H2,1H3,(H,29,30)(H2,25,26,27,31,32) GOSJFPJTVIDBKZ-UHFFFAOYSA-N 266125 US9718790, I-2140 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266125 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266125&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945645 377004997 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505688 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(CC(=O)N2CCOCC2)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C25H27Cl2N5O5/c1-16(2)37-21-8-7-19(13-20(21)27)28-23-29-24(34)32(15-22(33)30-9-11-36-12-10-30)25(35)31(23)14-17-3-5-18(26)6-4-17/h3-8,13,16H,9-12,14-15H2,1-2H3,(H,28,29,34) YEJGLDWUENFCCC-UHFFFAOYSA-N 266126 US9718790, I-0739 P2X purinoceptor 3 Homo sapiens 29.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266126 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266126&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019544 377004998 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505689 COC(=O)CCCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccnc(C)c3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C27H26ClN5O5/c1-18-16-23(13-14-29-18)38-22-11-9-21(10-12-22)30-25-31-26(35)32(15-3-4-24(34)37-2)27(36)33(25)17-19-5-7-20(28)8-6-19/h5-14,16H,3-4,15,17H2,1-2H3,(H,30,31,35) HPOPGIMWVZWHDI-UHFFFAOYSA-N 266127 US9718790, I-1396 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266127 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266127&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278507 377004999 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505690 OC(=O)c1cc(Oc2ccc(cc2F)\N=c2/[nH]c(=O)[nH]c(=O)n2Cc2ccc(Cl)cc2)ccn1 InChI=1S/C22H15ClFN5O5/c23-13-3-1-12(2-4-13)11-29-20(27-21(32)28-22(29)33)26-14-5-6-18(16(24)9-14)34-15-7-8-25-17(10-15)19(30)31/h1-10H,11H2,(H,30,31)(H2,26,27,28,32,33) ZQJDBPTTZDMGQE-UHFFFAOYSA-N 266128 US9718790, I-2141 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266128 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266128&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278607 377005000 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505691 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(CC(=O)N2CCN(CC2)C(=O)OC(C)(C)C)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C30H36Cl2N6O6/c1-19(2)43-24-11-10-22(16-23(24)32)33-26-34-27(40)38(28(41)37(26)17-20-6-8-21(31)9-7-20)18-25(39)35-12-14-36(15-13-35)29(42)44-30(3,4)5/h6-11,16,19H,12-15,17-18H2,1-5H3,(H,33,34,40) BGSUHCSZBDMULK-UHFFFAOYSA-N 266129 US9718790, I-0740 P2X purinoceptor 3 Homo sapiens 221 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266129 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266129&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278206 377005001 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505692 CCOC(=O)CCCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccnc(C)c3)cc2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C29H31N5O5/c1-4-38-26(35)6-5-17-33-28(36)32-27(34(29(33)37)19-22-9-7-20(2)8-10-22)31-23-11-13-24(14-12-23)39-25-15-16-30-21(3)18-25/h7-16,18H,4-6,17,19H2,1-3H3,(H,31,32,36) JCXODJYSGFBZDF-UHFFFAOYSA-N 266130 US9718790, I-1397 P2X purinoceptor 3 Homo sapiens 3.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266130 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266130&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945531 377005002 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505693 COC(=O)CCCn1c(=O)[nH]\c(=N/c2ccc3nc(C)sc3c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H22ClN5O4S/c1-14-25-18-10-9-17(12-19(18)34-14)26-21-27-22(31)28(11-3-4-20(30)33-2)23(32)29(21)13-15-5-7-16(24)8-6-15/h5-10,12H,3-4,11,13H2,1-2H3,(H,26,27,31) NNQBJQCUMTYZHC-UHFFFAOYSA-N 266131 US9718790, I-2142 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266131 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266131&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020579 377005003 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505694 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(OCC(F)F)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 266132 US9718790, I-0741 P2X purinoceptor 3 Homo sapiens 50.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266132 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266132&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 88558886 377005004 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505695 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2cnc(OC3CCC3)c(Cl)c2)n(Cc2ccc(C)cc2)c1=O 266133 US9718790, I-1398 P2X purinoceptor 3 Homo sapiens 25.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266133 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266133&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020457 377005005 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505696 Cc1nc2ccc(cc2s1)\N=c1/[nH]c(=O)n(CCCC(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C22H20ClN5O4S/c1-13-24-17-9-8-16(11-18(17)33-13)25-20-26-21(31)27(10-2-3-19(29)30)22(32)28(20)12-14-4-6-15(23)7-5-14/h4-9,11H,2-3,10,12H2,1H3,(H,29,30)(H,25,26,31) HXCJXJDQSPJPTL-UHFFFAOYSA-N 266134 US9718790, I-2143 P2X purinoceptor 3 Homo sapiens 23.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266134 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266134&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278608 377005006 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505697 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(CC(=O)N2CCNCC2)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C25H28Cl2N6O4/c1-16(2)37-21-8-7-19(13-20(21)27)29-23-30-24(35)33(15-22(34)31-11-9-28-10-12-31)25(36)32(23)14-17-3-5-18(26)6-4-17/h3-8,13,16,28H,9-12,14-15H2,1-2H3,(H,29,30,35) ROTMMLCKDFVRHU-UHFFFAOYSA-N 266135 US9718790, I-0742 P2X purinoceptor 3 Homo sapiens 38.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266135 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266135&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020777 377005007 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505698 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2cnc(OC3CCC3)c(Cl)c2)n(Cc2ccc(Cl)cc2)c1=O 266136 US9718790, I-1399 P2X purinoceptor 3 Homo sapiens 50.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266136 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266136&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278336 377005008 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505699 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(n3)C(N)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H21ClN6O4/c1-2-30-23(33)29-22(31(24(30)34)14-15-6-8-16(25)9-7-15)27-17-10-12-18(13-11-17)35-20-5-3-4-19(28-20)21(26)32/h3-13H,2,14H2,1H3,(H2,26,32)(H,27,29,33) JYJDTPHHEDDOQN-UHFFFAOYSA-N 266137 US9718790, I-2145 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266137 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266137&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021090 377005009 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505700 CCCOc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(C[C@H](C)C(=O)OC)c(=O)n1Cc1ccc(Cl)cc1 266138 US9718790, I-0743 P2X purinoceptor 3 Homo sapiens 13.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266138 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266138&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020779 377005010 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505701 CCOC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(OC3CCC3)c(C)c2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C27H32N4O5/c1-4-35-24(32)14-15-30-26(33)29-25(31(27(30)34)17-20-10-8-18(2)9-11-20)28-21-12-13-23(19(3)16-21)36-22-6-5-7-22/h8-13,16,22H,4-7,14-15,17H2,1-3H3,(H,28,29,33) BNEJPDUQXSXLDN-UHFFFAOYSA-N 266139 US9718790, I-1400 P2X purinoceptor 3 Homo sapiens 13.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266139 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266139&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278583 377005011 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505702 CCOC(=O)c1sc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(CC)c(=O)n2Cc2ccc(Cl)cc2)nc1C InChI=1S/C25H24ClN5O5S/c1-4-30-23(33)29-22(31(25(30)34)14-16-6-8-17(26)9-7-16)28-18-10-12-19(13-11-18)36-24-27-15(3)20(37-24)21(32)35-5-2/h6-13H,4-5,14H2,1-3H3,(H,28,29,33) MBGQDQLAFATJTH-UHFFFAOYSA-N 266140 US9718790, I-2147 P2X purinoceptor 3 Homo sapiens 14.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266140 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266140&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278632 377005012 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505703 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc3OCOCc3c2)n(Cc2ccc(Cl)cc2)c1=O 266141 US9718790, I-0744 P2X purinoceptor 3 Homo sapiens 53.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266141 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266141&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020772 377005013 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505704 CCOC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(OC3CCC3)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H29ClN4O5/c1-3-35-23(32)13-14-30-25(33)29-24(31(26(30)34)16-18-7-9-19(27)10-8-18)28-20-11-12-22(17(2)15-20)36-21-5-4-6-21/h7-12,15,21H,3-6,13-14,16H2,1-2H3,(H,28,29,33) BJFZMCPQPTWRQM-UHFFFAOYSA-N 266142 US9718790, I-1401 P2X purinoceptor 3 Homo sapiens 22.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266142 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266142&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945423 377005014 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505705 CCOC(=O)c1cnc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(CC)c(=O)n2Cc2ccc(Cl)cc2)s1 InChI=1S/C24H22ClN5O5S/c1-3-29-22(32)28-21(30(24(29)33)14-15-5-7-16(25)8-6-15)27-17-9-11-18(12-10-17)35-23-26-13-19(36-23)20(31)34-4-2/h5-13H,3-4,14H2,1-2H3,(H,27,28,32) YBEOOIJFRJKAHC-UHFFFAOYSA-N 266143 US9718790, I-2148 P2X purinoceptor 3 Homo sapiens 2.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266143 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266143&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020555 377005015 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505706 COCCOc1ccc(cc1)\N=c1/[nH]c(=O)n(C[C@H](C)C(=O)OC)c(=O)n1Cc1ccc(Cl)cc1 266144 US9718790, I-0745 P2X purinoceptor 3 Homo sapiens 125 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266144 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266144&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020775 377005016 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505707 COC(=O)[C@H](C)[C@H](C)n1c(=O)[nH]\c(=N/c2ccc(OC3CCC3)c(C)c2)n(Cc2ccc(C)cc2)c1=O 266145 US9718790, I-1402 P2X purinoceptor 3 Homo sapiens 33.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266145 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266145&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019924 377005017 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505708 CCOC(=O)Cc1c(C)oc2ccc(cc12)\N=c1/[nH]c(=O)n(CC)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C25H25ClN4O5/c1-4-29-24(32)28-23(30(25(29)33)14-16-6-8-17(26)9-7-16)27-18-10-11-21-20(12-18)19(15(3)35-21)13-22(31)34-5-2/h6-12H,4-5,13-14H2,1-3H3,(H,27,28,32) SOEYIBIGPUQEDD-UHFFFAOYSA-N 266146 US9718790, I-2149 P2X purinoceptor 3 Homo sapiens 791 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266146 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266146&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020640 377005018 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505709 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc3OCOCc3c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 266147 US9718790, I-0746 P2X purinoceptor 3 Homo sapiens 140 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266147 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266147&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020127 377005019 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505710 COC(=O)[C@H](C)[C@H](C)n1c(=O)[nH]\c(=N/c2ccc(OC3CCC3)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O 266148 US9718790, I-1403 P2X purinoceptor 3 Homo sapiens 50.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266148 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266148&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945398 377005020 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505711 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(o3)C(=O)OC)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H21ClN4O6/c1-3-28-23(31)27-22(29(24(28)32)14-15-4-6-16(25)7-5-15)26-17-8-10-18(11-9-17)34-20-13-12-19(35-20)21(30)33-2/h4-13H,3,14H2,1-2H3,(H,26,27,31) FBUVTVFTMRUQID-UHFFFAOYSA-N 266149 US9718790, I-2150 P2X purinoceptor 3 Homo sapiens 44.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266149 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266149&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020642 377005021 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505712 CCCOc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 266150 US9718790, I-0747 P2X purinoceptor 3 Homo sapiens 12.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266150 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266150&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020202 377005022 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505713 Cc1cc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(CCCC(O)=O)c(=O)n2Cc2ccc(Cl)cc2)ccn1 InChI=1S/C26H24ClN5O5/c1-17-15-22(12-13-28-17)37-21-10-8-20(9-11-21)29-24-30-25(35)31(14-2-3-23(33)34)26(36)32(24)16-18-4-6-19(27)7-5-18/h4-13,15H,2-3,14,16H2,1H3,(H,33,34)(H,29,30,35) ZMWBWUGEYRPAQO-UHFFFAOYSA-N 266151 US9718790, I-1404 P2X purinoceptor 3 Homo sapiens 24.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266151 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266151&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278193 377005023 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505714 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3nc(C)c(s3)C(O)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H20ClN5O5S/c1-3-28-21(32)27-20(29(23(28)33)12-14-4-6-15(24)7-5-14)26-16-8-10-17(11-9-16)34-22-25-13(2)18(35-22)19(30)31/h4-11H,3,12H2,1-2H3,(H,30,31)(H,26,27,32) GXYMHKKUECWFLK-UHFFFAOYSA-N 266152 US9718790, I-2151 P2X purinoceptor 3 Homo sapiens 12.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266152 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266152&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945601 377005024 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505715 COCCOc1ccc(cc1)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 266153 US9718790, I-0748 P2X purinoceptor 3 Homo sapiens 295 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266153 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266153&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945063 377005025 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505716 Cc1ccc(Cn2c(=O)n(CCCC(O)=O)c(=O)[nH]\c2=N/c2ccc(Oc3ccnc(C)c3)cc2)cc1 InChI=1S/C27H27N5O5/c1-18-5-7-20(8-6-18)17-32-25(30-26(35)31(27(32)36)15-3-4-24(33)34)29-21-9-11-22(12-10-21)37-23-13-14-28-19(2)16-23/h5-14,16H,3-4,15,17H2,1-2H3,(H,33,34)(H,29,30,35) AHONLFWSABNDBJ-UHFFFAOYSA-N 266154 US9718790, I-1405 P2X purinoceptor 3 Homo sapiens 26.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266154 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266154&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278337 377005026 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505717 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(o3)C(O)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H19ClN4O6/c1-2-27-22(31)26-21(28(23(27)32)13-14-3-5-15(24)6-4-14)25-16-7-9-17(10-8-16)33-19-12-11-18(34-19)20(29)30/h3-12H,2,13H2,1H3,(H,29,30)(H,25,26,31) LIUCRZXEYRMQPK-UHFFFAOYSA-N 266155 US9718790, I-2152 P2X purinoceptor 3 Homo sapiens 41.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266155 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266155&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117756969 377005027 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505718 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(OCC(C)C)cc2)n(Cc2ccc(Cl)cc2)c1=O 266156 US9718790, I-0749 P2X purinoceptor 3 Homo sapiens 27.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266156 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266156&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020204 377005028 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505719 Cc1ccc(Cn2c(=O)n(CCC(O)=O)c(=O)[nH]\c2=N/c2ccc(OC3CCC3)c(C)c2)cc1 InChI=1S/C25H28N4O5/c1-16-6-8-18(9-7-16)15-29-23(27-24(32)28(25(29)33)13-12-22(30)31)26-19-10-11-21(17(2)14-19)34-20-4-3-5-20/h6-11,14,20H,3-5,12-13,15H2,1-2H3,(H,30,31)(H,26,27,32) NLVSBYVBJRKYSN-UHFFFAOYSA-N 266157 US9718790, I-1406 P2X purinoceptor 3 Homo sapiens 64.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266157 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266157&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020462 377005029 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505720 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ncc(s3)C(O)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C22H18ClN5O5S/c1-2-27-20(31)26-19(28(22(27)32)12-13-3-5-14(23)6-4-13)25-15-7-9-16(10-8-15)33-21-24-11-17(34-21)18(29)30/h3-11H,2,12H2,1H3,(H,29,30)(H,25,26,31) CFNOJNBVBWXJKM-UHFFFAOYSA-N 266158 US9718790, I-2153 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266158 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266158&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020020 377005030 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505721 CC(C)COc1ccc(cc1)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 266159 US9718790, I-0750 P2X purinoceptor 3 Homo sapiens 22.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266159 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266159&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019985 377005031 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505722 Cc1cc(ccc1OC1CCC1)\N=c1/[nH]c(=O)n(CCC(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C24H25ClN4O5/c1-15-13-18(9-10-20(15)34-19-3-2-4-19)26-22-27-23(32)28(12-11-21(30)31)24(33)29(22)14-16-5-7-17(25)8-6-16/h5-10,13,19H,2-4,11-12,14H2,1H3,(H,30,31)(H,26,27,32) JTNODPOVLQDSKM-UHFFFAOYSA-N 266160 US9718790, I-1407 P2X purinoceptor 3 Homo sapiens 36.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266160 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266160&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020471 377005032 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505723 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cncc(c3)C(=O)OC)cc2)n(Cc2ccc(Cl)cn2)c1=O InChI=1S/C24H21ClN6O5/c1-3-30-23(33)29-22(31(24(30)34)14-18-5-4-16(25)12-27-18)28-17-6-8-19(9-7-17)36-20-10-15(11-26-13-20)21(32)35-2/h4-13H,3,14H2,1-2H3,(H,28,29,33) LXPVDHNQVNTUST-UHFFFAOYSA-N 266161 US9718790, I-2154 P2X purinoceptor 3 Homo sapiens 133 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266161 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266161&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278633 377005033 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505724 CC(C)Oc1ccc(cc1C)\N=c1/[nH]c(=O)n(C[C@@H]2CCC(=O)N2)c(=O)n1Cc1ccc(Cl)cc1 266162 US9718790, I-0751 P2X purinoceptor 3 Homo sapiens 21.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266162 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266162&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945193 377005034 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505725 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc(OC3CCC3)c(C)c2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 266163 US9718790, I-1408 P2X purinoceptor 3 Homo sapiens 16.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266163 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266163&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278334 377005035 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505726 COC(=O)CCCCn1c(=O)[nH]\c(=N/c2ccc3nc(C)sc3c2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C25H27N5O4S/c1-16-7-9-18(10-8-16)15-30-23(27-19-11-12-20-21(14-19)35-17(2)26-20)28-24(32)29(25(30)33)13-5-4-6-22(31)34-3/h7-12,14H,4-6,13,15H2,1-3H3,(H,27,28,32) PEMGHOVDHVMOHF-UHFFFAOYSA-N 266164 US9718790, I-2155 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266164 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266164&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019970 377005036 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505727 CC[C@H](C)Oc1ccc(cc1C)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 266165 US9718790, I-0752 P2X purinoceptor 3 Homo sapiens 34.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266165 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266165&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278264 377005037 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505728 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc(OC3CCC3)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 266166 US9718790, I-1409 P2X purinoceptor 3 Homo sapiens 17.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266166 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266166&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020519 377005038 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505729 CCc1nc2ccc(cc2s1)\N=c1/[nH]c(=O)n(CCCCC(=O)OC)c(=O)n1Cc1ccc(C)cc1 InChI=1S/C26H29N5O4S/c1-4-22-28-20-13-12-19(15-21(20)36-22)27-24-29-25(33)30(14-6-5-7-23(32)35-3)26(34)31(24)16-18-10-8-17(2)9-11-18/h8-13,15H,4-7,14,16H2,1-3H3,(H,27,29,33) PYUKMAGSSMRJMK-UHFFFAOYSA-N 266167 US9718790, I-2156 P2X purinoceptor 3 Homo sapiens 2.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266167 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266167&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019863 377005039 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505730 CC[C@@H](C)Oc1ccc(cc1C)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 266168 US9718790, I-0753 P2X purinoceptor 3 Homo sapiens 11.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266168 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266168&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278525 377005040 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505731 C[C@@H](Cn1c(=O)[nH]\c(=N/c2cnc(OC3CCC3)c(Cl)c2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 266169 US9718790, I-1410 P2X purinoceptor 3 Homo sapiens 56.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266169 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266169&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020464 377005041 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505732 CCCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(nc3)C(=O)OC)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H24ClN5O5/c1-3-14-31-25(34)30-24(32(26(31)35)16-17-4-6-18(27)7-5-17)29-19-8-10-20(11-9-19)37-21-12-13-22(28-15-21)23(33)36-2/h4-13,15H,3,14,16H2,1-2H3,(H,29,30,34) XGOUBOSJWVMAOH-UHFFFAOYSA-N 266170 US9718790, I-2157 P2X purinoceptor 3 Homo sapiens 1.000 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266170 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266170&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019784 377005042 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505733 CC[C@@H](C)Oc1ccc(cc1)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 266171 US9718790, I-0754 P2X purinoceptor 3 Homo sapiens 16.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266171 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266171&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118944976 377005043 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505734 C[C@@H](Cn1c(=O)[nH]\c(=N/c2cnc(OC3CCC3)c(Cl)c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 266172 US9718790, I-1411 P2X purinoceptor 3 Homo sapiens 58.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266172 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266172&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020112 377005044 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505735 Cc1nc2ccc(cc2s1)\N=c1/[nH]c(=O)n(CCCCC(O)=O)c(=O)n1Cc1ccc(C)cc1 InChI=1S/C24H25N5O4S/c1-15-6-8-17(9-7-15)14-29-22(26-18-10-11-19-20(13-18)34-16(2)25-19)27-23(32)28(24(29)33)12-4-3-5-21(30)31/h6-11,13H,3-5,12,14H2,1-2H3,(H,30,31)(H,26,27,32) LNJYBJJQCQPDJT-UHFFFAOYSA-N 266173 US9718790, I-2158 P2X purinoceptor 3 Homo sapiens 29.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266173 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266173&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019707 377005045 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505736 CC[C@H](C)Oc1ccc(cc1)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 266174 US9718790, I-0755 P2X purinoceptor 3 Homo sapiens 24.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266174 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266174&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945091 377005046 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505737 OC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cncc(F)c3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H19ClFN5O5/c25-16-3-1-15(2-4-16)14-31-22(29-23(34)30(24(31)35)10-9-21(32)33)28-18-5-7-19(8-6-18)36-20-11-17(26)12-27-13-20/h1-8,11-13H,9-10,14H2,(H,32,33)(H,28,29,34) PGCNVNUKNQVADU-UHFFFAOYSA-N 266175 US9718790, I-1412 P2X purinoceptor 3 Homo sapiens 11.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266175 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266175&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020140 377005047 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505738 CCc1nc2ccc(cc2s1)\N=c1/[nH]c(=O)n(CCCCC(O)=O)c(=O)n1Cc1ccc(C)cc1 InChI=1S/C25H27N5O4S/c1-3-21-27-19-12-11-18(14-20(19)35-21)26-23-28-24(33)29(13-5-4-6-22(31)32)25(34)30(23)15-17-9-7-16(2)8-10-17/h7-12,14H,3-6,13,15H2,1-2H3,(H,31,32)(H,26,28,33) IMZMSTCCPIEIPW-UHFFFAOYSA-N 266176 US9718790, I-2159 P2X purinoceptor 3 Homo sapiens 47.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266176 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266176&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019645 377005048 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505739 CO\N=C(/Cn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O InChI=1S/C24H26ClN5O6/c1-14(2)36-20-10-9-18(11-15(20)3)26-22-27-23(33)30(13-19(21(31)32)28-35-4)24(34)29(22)12-16-5-7-17(25)8-6-16/h5-11,14H,12-13H2,1-4H3,(H,31,32)(H,26,27,33)/b28-19+ WHJAZEPHUXUGSM-TURZUDJPSA-N 266177 US9718790, I-0756 P2X purinoceptor 3 Homo sapiens 131 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266177 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266177&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278272 377005049 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505740 Cc1ccc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(CCC(O)=O)c(=O)n2Cc2ccc(Cl)cc2)c(C)n1 InChI=1S/C26H24ClN5O5/c1-16-3-12-22(17(2)28-16)37-21-10-8-20(9-11-21)29-24-30-25(35)31(14-13-23(33)34)26(36)32(24)15-18-4-6-19(27)7-5-18/h3-12H,13-15H2,1-2H3,(H,33,34)(H,29,30,35) UZLGIRJJFMVSAW-UHFFFAOYSA-N 266178 US9718790, I-1413 P2X purinoceptor 3 Homo sapiens 72.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266178 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266178&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278260 377005050 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505741 CCCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccnc(c3)C(=O)OC)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H24ClN5O5/c1-3-14-31-25(34)30-24(32(26(31)35)16-17-4-6-18(27)7-5-17)29-19-8-10-20(11-9-19)37-21-12-13-28-22(15-21)23(33)36-2/h4-13,15H,3,14,16H2,1-2H3,(H,29,30,34) WKZHEZOVIVNLGJ-UHFFFAOYSA-N 266179 US9718790, I-2160 P2X purinoceptor 3 Homo sapiens 3.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266179 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266179&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945227 377005051 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505742 COC(=O)Cn1cccc(Cn2c(=O)[nH]\c(=N/c3ccc(OC(C)C)c(C)c3)n(Cc3ccc(Cl)cc3)c2=O)c1=O InChI=1S/C29H30ClN5O6/c1-18(2)41-24-12-11-23(14-19(24)3)31-27-32-28(38)35(29(39)34(27)15-20-7-9-22(30)10-8-20)16-21-6-5-13-33(26(21)37)17-25(36)40-4/h5-14,18H,15-17H2,1-4H3,(H,31,32,38) OUELCSJPOSCUMM-UHFFFAOYSA-N 266180 US9718790, I-0757 P2X purinoceptor 3 Homo sapiens 35.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266180 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266180&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278526 377005052 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505743 CC(C)NC(=O)c1ccc(cc1Cl)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 266181 US9718790, I-1414 P2X purinoceptor 3 Homo sapiens 986 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266181 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266181&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020201 377005053 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505744 CCCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(nc3)C(O)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H22ClN5O5/c1-2-13-30-24(34)29-23(31(25(30)35)15-16-3-5-17(26)6-4-16)28-18-7-9-19(10-8-18)36-20-11-12-21(22(32)33)27-14-20/h3-12,14H,2,13,15H2,1H3,(H,32,33)(H,28,29,34) JSGQOWOREXSOJU-UHFFFAOYSA-N 266182 US9718790, I-2161 P2X purinoceptor 3 Homo sapiens 14.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266182 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266182&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278226 377005054 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505745 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n(CCC(=O)NC#N)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C23H22ClFN6O4/c1-14(2)35-19-8-7-17(11-18(19)25)28-21-29-22(33)30(10-9-20(32)27-13-26)23(34)31(21)12-15-3-5-16(24)6-4-15/h3-8,11,14H,9-10,12H2,1-2H3,(H,27,32)(H,28,29,33) FBOBKOADMZHIMR-UHFFFAOYSA-N 266183 US9718790, I-0758 P2X purinoceptor 3 Homo sapiens 19.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266183 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266183&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 86689095 377005055 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505746 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(NC(C)=O)cc2)n(Cc2ccc(C)cc2)c1=O 266184 US9718790, I-1415 P2X purinoceptor 3 Homo sapiens 532 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266184 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266184&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020113 377005056 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505747 CCCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccnc(c3)C(O)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H22ClN5O5/c1-2-13-30-24(34)29-23(31(25(30)35)15-16-3-5-17(26)6-4-16)28-18-7-9-19(10-8-18)36-20-11-12-27-21(14-20)22(32)33/h3-12,14H,2,13,15H2,1H3,(H,32,33)(H,28,29,34) FHEMIVSNWGHSOX-UHFFFAOYSA-N 266185 US9718790, I-2162 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266185 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266185&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278428 377005057 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505748 CC(C)Oc1ccc(cc1C)\N=c1/[nH]c(=O)n(Cc2cccn(CC(O)=O)c2=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C28H28ClN5O6/c1-17(2)40-23-11-10-22(13-18(23)3)30-26-31-27(38)34(15-20-5-4-12-32(25(20)37)16-24(35)36)28(39)33(26)14-19-6-8-21(29)9-7-19/h4-13,17H,14-16H2,1-3H3,(H,35,36)(H,30,31,38) BEEKGQHBVALOCX-UHFFFAOYSA-N 266186 US9718790, I-0760 P2X purinoceptor 3 Homo sapiens 37.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266186 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266186&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019783 377005058 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505749 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(NS(C)(=O)=O)cc2)n(Cc2ccc(C)cc2)c1=O 266187 US9718790, I-1416 P2X purinoceptor 3 Homo sapiens 141 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266187 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266187&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019770 377005059 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505750 Cc1nc2ccc(cc2s1)\N=c1/[nH]c(=O)n(CCNCCO)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C22H23ClN6O3S/c1-14-25-18-7-6-17(12-19(18)33-14)26-20-27-21(31)28(10-8-24-9-11-30)22(32)29(20)13-15-2-4-16(23)5-3-15/h2-7,12,24,30H,8-11,13H2,1H3,(H,26,27,31) QNXULVPVYDJMHF-UHFFFAOYSA-N 266188 US9718790, I-2163 P2X purinoceptor 3 Homo sapiens 54.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266188 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266188&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020966 377005060 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505751 COC(=O)C[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O 266189 US9718790, I-0761 P2X purinoceptor 3 Homo sapiens 15.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266189 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266189&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945090 377005061 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505752 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(NS(C)(=O)=O)cc2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 266190 US9718790, I-1417 P2X purinoceptor 3 Homo sapiens 207 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266190 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266190&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019772 377005062 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505753 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cncc(c3)C(O)=O)cc2)n(Cc2ccc(Cl)cn2)c1=O InChI=1S/C23H19ClN6O5/c1-2-29-22(33)28-21(30(23(29)34)13-17-4-3-15(24)11-26-17)27-16-5-7-18(8-6-16)35-19-9-14(20(31)32)10-25-12-19/h3-12H,2,13H2,1H3,(H,31,32)(H,27,28,33) MNWFQRBZSOBFPQ-UHFFFAOYSA-N 266191 US9718790, I-2164 P2X purinoceptor 3 Homo sapiens 125 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266191 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266191&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278609 377005063 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505754 CC(C)Oc1ccc(cc1C)\N=c1/[nH]c(=O)n(-c2ccc(cc2)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C27H25ClN4O5/c1-16(2)37-23-13-10-21(14-17(23)3)29-25-30-26(35)32(22-11-6-19(7-12-22)24(33)34)27(36)31(25)15-18-4-8-20(28)9-5-18/h4-14,16H,15H2,1-3H3,(H,33,34)(H,29,30,35) XIVYNVOMACELOJ-UHFFFAOYSA-N 266192 US9718790, I-0762 P2X purinoceptor 3 Homo sapiens 82.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266192 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266192&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945060 377005064 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505755 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(NC(=O)C(C)C)c(Cl)c2)n(Cc2ccc(C)cc2)c1=O 266193 US9718790, I-1419 P2X purinoceptor 3 Homo sapiens 304 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266193 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266193&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019942 377005065 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505756 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cc(ccn3)C(N)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H21ClN6O4/c1-2-30-23(33)29-22(31(24(30)34)14-15-3-5-17(25)6-4-15)28-18-7-9-19(10-8-18)35-20-13-16(21(26)32)11-12-27-20/h3-13H,2,14H2,1H3,(H2,26,32)(H,28,29,33) CCOFNNFDWDSTHB-UHFFFAOYSA-N 266194 US9718790, I-2165 P2X purinoceptor 3 Homo sapiens 979 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266194 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266194&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020944 377005066 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505757 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(Cl)c2)n(Cc2ccccc2)c1=O 266195 US9718790, I-0763 P2X purinoceptor 3 Homo sapiens 80.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266195 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266195&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278273 377005067 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505758 CC(C)C(=O)Nc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(C)cc1 266196 US9718790, I-1420 P2X purinoceptor 3 Homo sapiens 607 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266196 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266196&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019943 377005068 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505759 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccnc(N)c3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H21ClN6O3/c1-2-29-22(31)28-21(30(23(29)32)14-15-3-5-16(24)6-4-15)27-17-7-9-18(10-8-17)33-19-11-12-26-20(25)13-19/h3-13H,2,14H2,1H3,(H2,25,26)(H,27,28,31) IDAXEQKDTSXBSB-UHFFFAOYSA-N 266197 US9718790, I-2166 P2X purinoceptor 3 Homo sapiens 10.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266197 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266197&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945612 377005069 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505760 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(C)c2)n(Cc2ccccc2)c1=O 266198 US9718790, I-0764 P2X purinoceptor 3 Homo sapiens 254 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266198 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266198&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278163 377005070 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505761 CCOC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(COC)c2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C27H34N4O6/c1-6-36-24(32)13-14-30-26(33)29-25(31(27(30)34)16-20-9-7-19(4)8-10-20)28-22-11-12-23(37-18(2)3)21(15-22)17-35-5/h7-12,15,18H,6,13-14,16-17H2,1-5H3,(H,28,29,33) DUWKECNMACNPSA-UHFFFAOYSA-N 266199 US9718790, I-1421 P2X purinoceptor 3 Homo sapiens 883 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266199 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266199&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945176 377005071 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505762 OCCn1c(=O)[nH]\c(=N/c2ccc3nc(sc3c2)C(F)(F)F)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C20H15ClF3N5O3S/c21-12-3-1-11(2-4-12)10-29-17(27-18(31)28(7-8-30)19(29)32)25-13-5-6-14-15(9-13)33-16(26-14)20(22,23)24/h1-6,9,30H,7-8,10H2,(H,25,27,31) VGAMTFRYBXFLSH-UHFFFAOYSA-N 266200 US9718790, I-2167 P2X purinoceptor 3 Homo sapiens 54.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266200 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266200&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020352 377005072 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505763 CC(C)Oc1ccc(cc1C)\N=c1/[nH]c(=O)n(C[C@H](C)CC(O)=O)c(=O)n1Cc1ccc(Cl)cc1 266201 US9718790, I-0765 P2X purinoceptor 3 Homo sapiens 40.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266201 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266201&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945146 377005073 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505764 COCc1cc(ccc1OC(C)C)\N=c1/[nH]c(=O)n(CC(C)(C)C(=O)OC)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C27H33ClN4O6/c1-17(2)38-22-12-11-21(13-19(22)15-36-5)29-24-30-25(34)32(16-27(3,4)23(33)37-6)26(35)31(24)14-18-7-9-20(28)10-8-18/h7-13,17H,14-16H2,1-6H3,(H,29,30,34) UVJCQGLOFUPIFH-UHFFFAOYSA-N 266202 US9718790, I-1422 P2X purinoceptor 3 Homo sapiens 529 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266202 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266202&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945150 377005074 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505765 OC[C@@H](O)Cn1c(=O)[nH]\c(=N/c2ccc3nc(sc3c2)C(F)(F)F)n(Cc2ccc(Cl)cc2)c1=O 266203 US9718790, I-2168 P2X purinoceptor 3 Homo sapiens 57.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266203 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266203&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020314 377005075 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505766 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(CC#N)c(Cl)c2)n(Cc2ccc(Cl)cc2)c1=O 266204 US9718790, I-0766 P2X purinoceptor 3 Homo sapiens 438 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266204 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266204&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278464 377005076 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505767 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(CO)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H31ClN4O6/c1-16(2)37-21-11-10-20(12-18(21)14-32)28-23-29-24(34)31(15-26(3,4)22(33)36-5)25(35)30(23)13-17-6-8-19(27)9-7-17/h6-12,16,32H,13-15H2,1-5H3,(H,28,29,34) XURMXIHUIOGXAI-UHFFFAOYSA-N 266205 US9718790, I-1423 P2X purinoceptor 3 Homo sapiens 41.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266205 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266205&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278584 377005077 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505768 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ncc(o3)C(O)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C22H18ClN5O6/c1-2-27-20(31)26-19(28(22(27)32)12-13-3-5-14(23)6-4-13)25-15-7-9-16(10-8-15)33-21-24-11-17(34-21)18(29)30/h3-11H,2,12H2,1H3,(H,29,30)(H,25,26,31) OXAZHNXGYGAVRX-UHFFFAOYSA-N 266206 US9718790, I-2189 P2X purinoceptor 3 Homo sapiens 51.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266206 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266206&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278429 377005078 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505769 COCCOc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(C[C@H](C)C(=O)OC)c(=O)n1Cc1ccc(Cl)cc1 266207 US9718790, I-0767 P2X purinoceptor 3 Homo sapiens 88.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266207 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266207&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020145 377005079 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505770 CCOC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(CO)c2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C26H32N4O6/c1-5-35-23(32)12-13-29-25(33)28-24(30(26(29)34)15-19-8-6-18(4)7-9-19)27-21-10-11-22(36-17(2)3)20(14-21)16-31/h6-11,14,17,31H,5,12-13,15-16H2,1-4H3,(H,27,28,33) FCLWQYAQRRXVKZ-UHFFFAOYSA-N 266208 US9718790, I-1424 P2X purinoceptor 3 Homo sapiens 35.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266208 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266208&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020882 377005080 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505771 CCn1c(=O)[nH]\c(=N/c2ccc3oc(C)c(CC(O)=O)c3c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H21ClN4O5/c1-3-27-22(31)26-21(28(23(27)32)12-14-4-6-15(24)7-5-14)25-16-8-9-19-18(10-16)17(11-20(29)30)13(2)33-19/h4-10H,3,11-12H2,1-2H3,(H,29,30)(H,25,26,31) COUAYOZMFYHGEJ-UHFFFAOYSA-N 266209 US9718790, I-2170 P2X purinoceptor 3 Homo sapiens 819 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266209 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266209&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020326 377005081 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505772 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc3CCCc3c2)n(Cc2ccc(Cl)cc2)c1=O 266210 US9718790, I-0769 P2X purinoceptor 3 Homo sapiens 207 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266210 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266210&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020139 377005082 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505773 CCOC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(COC(C)=O)c2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C28H34N4O7/c1-6-37-25(34)13-14-31-27(35)30-26(32(28(31)36)16-21-9-7-19(4)8-10-21)29-23-11-12-24(39-18(2)3)22(15-23)17-38-20(5)33/h7-12,15,18H,6,13-14,16-17H2,1-5H3,(H,29,30,35) JJVPAFXWLNVVDW-UHFFFAOYSA-N 266211 US9718790, I-1425 P2X purinoceptor 3 Homo sapiens 50.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266211 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266211&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020865 377005083 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505774 CCn1c(=O)[nH]\c(=N/c2ccc3oc(C)c(CCO)c3c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H23ClN4O4/c1-3-27-22(30)26-21(28(23(27)31)13-15-4-6-16(24)7-5-15)25-17-8-9-20-19(12-17)18(10-11-29)14(2)32-20/h4-9,12,29H,3,10-11,13H2,1-2H3,(H,25,26,30) SFLUHMAXLLXOEP-UHFFFAOYSA-N 266212 US9718790, I-2171 P2X purinoceptor 3 Homo sapiens 296 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266212 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266212&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020646 377005084 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505775 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc3OCCc3c2)n(Cc2ccc(Cl)cc2)c1=O 266213 US9718790, I-0770 P2X purinoceptor 3 Homo sapiens 405 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266213 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266213&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019991 377005085 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505776 CCOC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(CC(C)C)c(Cl)c2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C26H31ClN4O4/c1-5-35-23(32)12-13-30-25(33)29-24(28-21-11-10-20(14-17(2)3)22(27)15-21)31(26(30)34)16-19-8-6-18(4)7-9-19/h6-11,15,17H,5,12-14,16H2,1-4H3,(H,28,29,33) XWZWZDMJSSNPTB-UHFFFAOYSA-N 266214 US9718790, I-1426 P2X purinoceptor 3 Homo sapiens 50.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266214 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266214&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019649 377005086 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505777 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(nc3)[N+]([O-])=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H19ClN6O5/c1-2-28-22(31)27-21(29(23(28)32)14-15-3-5-16(24)6-4-15)26-17-7-9-18(10-8-17)35-19-11-12-20(25-13-19)30(33)34/h3-13H,2,14H2,1H3,(H,26,27,31) VYFQRVHDHNYOHB-UHFFFAOYSA-N 266215 US9718790, I-2172 P2X purinoceptor 3 Homo sapiens 1.000 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266215 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266215&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278642 377005087 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505778 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc3CCCc3c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 266216 US9718790, I-0772 P2X purinoceptor 3 Homo sapiens 477 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266216 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266216&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019884 377005088 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505779 CC(C)Cc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(CCC(O)=O)c(=O)n1Cc1ccc(C)cc1 InChI=1S/C24H27ClN4O4/c1-15(2)12-18-8-9-19(13-20(18)25)26-22-27-23(32)28(11-10-21(30)31)24(33)29(22)14-17-6-4-16(3)5-7-17/h4-9,13,15H,10-12,14H2,1-3H3,(H,30,31)(H,26,27,32) SELSRVYQWNHIBE-UHFFFAOYSA-N 266217 US9718790, I-1427 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266217 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266217&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019697 377005089 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505780 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cncc(c3)C(=O)OC)cc2)n(CC2CCC3(CC3)CC2)c1=O InChI=1S/C27H31N5O5/c1-3-31-25(34)30-24(32(26(31)35)17-18-8-10-27(11-9-18)12-13-27)29-20-4-6-21(7-5-20)37-22-14-19(15-28-16-22)23(33)36-2/h4-7,14-16,18H,3,8-13,17H2,1-2H3,(H,29,30,34) LUFATGWTNMVUFB-UHFFFAOYSA-N 266218 US9718790, I-2173 P2X purinoceptor 3 Homo sapiens 12.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266218 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266218&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020603 377005090 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505781 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc3OCCc3c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 266219 US9718790, I-0773 P2X purinoceptor 3 Homo sapiens 790 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266219 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266219&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019622 377005091 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505782 COCc1cc(ccc1OC(C)C)\N=c1/[nH]c(=O)n(CCC(O)=O)c(=O)n1Cc1ccc(C)cc1 InChI=1S/C25H30N4O6/c1-16(2)35-21-10-9-20(13-19(21)15-34-4)26-23-27-24(32)28(12-11-22(30)31)25(33)29(23)14-18-7-5-17(3)6-8-18/h5-10,13,16H,11-12,14-15H2,1-4H3,(H,30,31)(H,26,27,32) YTTRVHQFRQTVPI-UHFFFAOYSA-N 266220 US9718790, I-1428 P2X purinoceptor 3 Homo sapiens 926 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266220 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266220&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019760 377005092 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505783 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccnc(c3)C(=O)OC)cc2)n(CC2CCC3(CC3)CC2)c1=O InChI=1S/C27H31N5O5/c1-3-31-25(34)30-24(32(26(31)35)17-18-8-11-27(12-9-18)13-14-27)29-19-4-6-20(7-5-19)37-21-10-15-28-22(16-21)23(33)36-2/h4-7,10,15-16,18H,3,8-9,11-14,17H2,1-2H3,(H,29,30,34) VFPQVCOHVIZQKS-UHFFFAOYSA-N 266221 US9718790, I-2174 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266221 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266221&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020585 377005093 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505784 CC(C)Oc1ccc(cc1C)\N=c1/[nH]c(=O)n(CCN2CCCC2=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C26H30ClN5O4/c1-17(2)36-22-11-10-21(15-18(22)3)28-24-29-25(34)31(14-13-30-12-4-5-23(30)33)26(35)32(24)16-19-6-8-20(27)9-7-19/h6-11,15,17H,4-5,12-14,16H2,1-3H3,(H,28,29,34) UPNFNUXIKWIVNB-UHFFFAOYSA-N 266222 US9718790, I-0774 P2X purinoceptor 3 Homo sapiens 54.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266222 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266222&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019623 377005094 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505785 CC(C)Oc1ccc(cc1CO)\N=c1/[nH]c(=O)n(CCC(O)=O)c(=O)n1Cc1ccc(C)cc1 InChI=1S/C24H28N4O6/c1-15(2)34-20-9-8-19(12-18(20)14-29)25-22-26-23(32)27(11-10-21(30)31)24(33)28(22)13-17-6-4-16(3)5-7-17/h4-9,12,15,29H,10-11,13-14H2,1-3H3,(H,30,31)(H,25,26,32) NCMADRBYKVCBNZ-UHFFFAOYSA-N 266223 US9718790, I-1429 P2X purinoceptor 3 Homo sapiens 232 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266223 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266223&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019678 377005095 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505786 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cncc(c3)C(O)=O)cc2)n(CC2CCC3(CC3)CC2)c1=O InChI=1S/C26H29N5O5/c1-2-30-24(34)29-23(31(25(30)35)16-17-7-9-26(10-8-17)11-12-26)28-19-3-5-20(6-4-19)36-21-13-18(22(32)33)14-27-15-21/h3-6,13-15,17H,2,7-12,16H2,1H3,(H,32,33)(H,28,29,34) SCACDHZKYSDZCL-UHFFFAOYSA-N 266224 US9718790, I-2175 P2X purinoceptor 3 Homo sapiens 13.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266224 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266224&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020605 377005096 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505787 CC(C)Oc1ccc(cc1C)\N=c1/[nH]c(=O)n([C@H]2CCOC2=O)c(=O)n1Cc1ccc(Cl)cc1 266225 US9718790, I-0775 P2X purinoceptor 3 Homo sapiens 41.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266225 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266225&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019885 377005097 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505788 COCc1cc(ccc1OC(C)C)\N=c1/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C26H31ClN4O6/c1-16(2)37-21-11-10-20(12-18(21)14-36-5)28-23-29-24(34)31(15-26(3,4)22(32)33)25(35)30(23)13-17-6-8-19(27)9-7-17/h6-12,16H,13-15H2,1-5H3,(H,32,33)(H,28,29,34) BXFCBXPVBGCTPG-UHFFFAOYSA-N 266226 US9718790, I-1430 P2X purinoceptor 3 Homo sapiens 709 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266226 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266226&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278338 377005098 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505789 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccnc(c3)C(N)=O)cc2)n(CC2CCC3(CC3)CC2)c1=O InChI=1S/C26H30N6O4/c1-2-31-24(34)30-23(32(25(31)35)16-17-7-10-26(11-8-17)12-13-26)29-18-3-5-19(6-4-18)36-20-9-14-28-21(15-20)22(27)33/h3-6,9,14-15,17H,2,7-8,10-13,16H2,1H3,(H2,27,33)(H,29,30,34) RXPSQPMUKJBXLG-UHFFFAOYSA-N 266227 US9718790, I-2176 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266227 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266227&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021148 377005099 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505790 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2cccc(c2)C(C)C)n(Cc2ccc(Cl)cc2)c1=O 266228 US9718790, I-0777 P2X purinoceptor 3 Homo sapiens 116 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266228 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266228&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020134 377005100 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505791 CC(C)Oc1ccc(cc1CO)\N=c1/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C25H29ClN4O6/c1-15(2)36-20-10-9-19(11-17(20)13-31)27-22-28-23(34)30(14-25(3,4)21(32)33)24(35)29(22)12-16-5-7-18(26)8-6-16/h5-11,15,31H,12-14H2,1-4H3,(H,32,33)(H,27,28,34) UDZCCKADECRQJT-UHFFFAOYSA-N 266229 US9718790, I-1431 P2X purinoceptor 3 Homo sapiens 242 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266229 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266229&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278511 377005101 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505792 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccnc(c3)C(O)=O)cc2)n(CC2CCC3(CC3)CC2)c1=O InChI=1S/C26H29N5O5/c1-2-30-24(34)29-23(31(25(30)35)16-17-7-10-26(11-8-17)12-13-26)28-18-3-5-19(6-4-18)36-20-9-14-27-21(15-20)22(32)33/h3-6,9,14-15,17H,2,7-8,10-13,16H2,1H3,(H,32,33)(H,28,29,34) OICXOHQBWDJYGT-UHFFFAOYSA-N 266230 US9718790, I-2177 P2X purinoceptor 3 Homo sapiens 14.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266230 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266230&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021142 377005102 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505793 CCOC(=O)C(CNc1ccc(OC(C)C)c(C)c1)Cn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O 266231 US9718790, I-0778 P2X purinoceptor 3 Homo sapiens 84.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266231 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266231&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020082 377005103 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505794 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccnc(O)c3)cc2)n(Cc2ccc(C)cc2)c1=O 266232 US9718790, I-1432 P2X purinoceptor 3 Homo sapiens 2.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266232 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266232&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945543 377005104 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505795 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cncc(c3)C(N)=O)cc2)n(CC2CCC3(CC3)CC2)c1=O InChI=1S/C26H30N6O4/c1-2-31-24(34)30-23(32(25(31)35)16-17-7-9-26(10-8-17)11-12-26)29-19-3-5-20(6-4-19)36-21-13-18(22(27)33)14-28-15-21/h3-6,13-15,17H,2,7-12,16H2,1H3,(H2,27,33)(H,29,30,34) FBXANVPBYOSJFE-UHFFFAOYSA-N 266233 US9718790, I-2178 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266233 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266233&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021136 377005105 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505796 CCOC(=O)C(=C)Cn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H29ClN4O5/c1-6-35-23(32)18(5)14-31-25(33)29-24(28-21-11-12-22(17(4)13-21)36-16(2)3)30(26(31)34)15-19-7-9-20(27)10-8-19/h7-13,16H,5-6,14-15H2,1-4H3,(H,28,29,33) YATHNUIUGZIVPM-UHFFFAOYSA-N 266234 US9718790, I-0779 P2X purinoceptor 3 Homo sapiens 16.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266234 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266234&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020103 377005106 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505797 CCOC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccnc(O)c3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H24ClN5O6/c1-2-37-23(34)12-14-31-25(35)30-24(32(26(31)36)16-17-3-5-18(27)6-4-17)29-19-7-9-20(10-8-19)38-21-11-13-28-22(33)15-21/h3-11,13,15H,2,12,14,16H2,1H3,(H,28,33)(H,29,30,35) IGLLYYBQJHCOCG-UHFFFAOYSA-N 266235 US9718790, I-1434 P2X purinoceptor 3 Homo sapiens 2.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266235 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266235&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020300 377005107 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505798 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cncc(c3)C#N)cc2)n(CC2CCC3(CC3)CC2)c1=O InChI=1S/C26H28N6O3/c1-2-31-24(33)30-23(32(25(31)34)17-18-7-9-26(10-8-18)11-12-26)29-20-3-5-21(6-4-20)35-22-13-19(14-27)15-28-16-22/h3-6,13,15-16,18H,2,7-12,17H2,1H3,(H,29,30,33) COVVNZDIMDTAHC-UHFFFAOYSA-N 266236 US9718790, I-2179 P2X purinoceptor 3 Homo sapiens 3.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266236 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266236&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945505 377005108 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505799 COC(=O)c1coc(Cn2c(=O)[nH]\c(=N/c3ccc(OC(C)C)c(C)c3)n(Cc3ccc(Cl)cc3)c2=O)n1 InChI=1S/C26H26ClN5O6/c1-15(2)38-21-10-9-19(11-16(21)3)28-24-30-25(34)32(13-22-29-20(14-37-22)23(33)36-4)26(35)31(24)12-17-5-7-18(27)8-6-17/h5-11,14-15H,12-13H2,1-4H3,(H,28,30,34) YBJLNVUINVJIAU-UHFFFAOYSA-N 266237 US9718790, I-0780 P2X purinoceptor 3 Homo sapiens 15.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266237 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266237&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019978 377005109 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505800 COC(=O)[C@H](C)[C@H](C)n1c(=O)[nH]\c(=N/c2ccc(CC(C)C)c(Cl)c2)n(Cc2ccc(Cl)cc2)c1=O 266238 US9718790, I-1435 P2X purinoceptor 3 Homo sapiens 61.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266238 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266238&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020120 377005110 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505801 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(n3)C(=O)OC)cc2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C26H25N5O5/c1-4-30-25(33)29-24(31(26(30)34)16-18-10-8-17(2)9-11-18)27-19-12-14-20(15-13-19)36-22-7-5-6-21(28-22)23(32)35-3/h5-15H,4,16H2,1-3H3,(H,27,29,33) GGLXUJNBRLBHMF-UHFFFAOYSA-N 266239 US9718790, I-2180 P2X purinoceptor 3 Homo sapiens 11.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266239 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266239&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945611 377005111 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505802 COC(=O)c1cccc(Cn2c(=O)[nH]\c(=N/c3ccc(OC(C)C)c(C)c3)n(Cc3ccc(Cl)cc3)c2=O)n1 InChI=1S/C28H28ClN5O5/c1-17(2)39-24-13-12-21(14-18(24)3)31-26-32-27(36)34(16-22-6-5-7-23(30-22)25(35)38-4)28(37)33(26)15-19-8-10-20(29)11-9-19/h5-14,17H,15-16H2,1-4H3,(H,31,32,36) AVSNETIFMLCUDV-UHFFFAOYSA-N 266240 US9718790, I-0781 P2X purinoceptor 3 Homo sapiens 9.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266240 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266240&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019732 377005112 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505803 COC(=O)[C@H](C)[C@H](C)n1c(=O)[nH]\c(=N/c2ccc(CC(C)C)c(Cl)c2)n(Cc2ccc(C)cc2)c1=O 266241 US9718790, I-1436 P2X purinoceptor 3 Homo sapiens 54.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266241 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266241&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945155 377005113 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505804 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(n3)C(O)=O)cc2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C25H23N5O5/c1-3-29-24(33)28-23(30(25(29)34)15-17-9-7-16(2)8-10-17)26-18-11-13-19(14-12-18)35-21-6-4-5-20(27-21)22(31)32/h4-14H,3,15H2,1-2H3,(H,31,32)(H,26,28,33) AAXJYXFLDXVJHF-UHFFFAOYSA-N 266242 US9718790, I-2181 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266242 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266242&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945641 377005114 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505805 CC[C@@H](CC(=O)OC)n1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O 266243 US9718790, I-0782 P2X purinoceptor 3 Homo sapiens 192 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266243 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266243&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019870 377005115 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505806 COC(=O)[C@@H](C)[C@@H](C)n1c(=O)[nH]\c(=N/c2ccc(CC(C)C)c(Cl)c2)n(Cc2ccc(Cl)cc2)c1=O 266244 US9718790, I-1438 P2X purinoceptor 3 Homo sapiens 63.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266244 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266244&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945421 377005116 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505807 COC(=O)CCCCn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(Cl)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H28Cl2N4O5/c1-16(2)36-21-12-11-19(14-20(21)27)28-23-29-24(33)30(13-5-4-6-22(32)35-3)25(34)31(23)15-17-7-9-18(26)10-8-17/h7-12,14,16H,4-6,13,15H2,1-3H3,(H,28,29,33) KISQJMHKVUSQPK-UHFFFAOYSA-N 266245 US9718790, I-2182 P2X purinoceptor 3 Homo sapiens 3.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266245 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266245&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945660 377005117 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505808 CC[C@H](CC(=O)OC)n1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O 266246 US9718790, I-0783 P2X purinoceptor 3 Homo sapiens 65.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266246 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266246&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945026 377005118 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505809 COC(=O)[C@@H](C)[C@@H](C)n1c(=O)[nH]\c(=N/c2ccc(CC(C)C)c(Cl)c2)n(Cc2ccc(C)cc2)c1=O 266247 US9718790, I-1439 P2X purinoceptor 3 Homo sapiens 39.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266247 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266247&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019921 377005119 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505810 CCc1nc2ccc(cc2s1)\N=c1/[nH]c(=O)n(CCCCC(=O)OC)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C25H26ClN5O4S/c1-3-21-28-19-12-11-18(14-20(19)36-21)27-23-29-24(33)30(13-5-4-6-22(32)35-2)25(34)31(23)15-16-7-9-17(26)10-8-16/h7-12,14H,3-6,13,15H2,1-2H3,(H,27,29,33) UYZBQUJDZNAZES-UHFFFAOYSA-N 266248 US9718790, I-2183 P2X purinoceptor 3 Homo sapiens 1.000 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266248 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266248&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945520 377005120 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505811 CCOC(=O)c1cc(Cn2c(=O)[nH]\c(=N/c3ccc(OC(C)C)c(C)c3)n(Cc3ccc(Cl)cc3)c2=O)on1 InChI=1S/C27H28ClN5O6/c1-5-37-24(34)22-13-21(39-31-22)15-33-26(35)30-25(29-20-10-11-23(17(4)12-20)38-16(2)3)32(27(33)36)14-18-6-8-19(28)9-7-18/h6-13,16H,5,14-15H2,1-4H3,(H,29,30,35) LIAPUARSZSUXKS-UHFFFAOYSA-N 266249 US9718790, I-0784 P2X purinoceptor 3 Homo sapiens 22.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266249 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266249&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019872 377005121 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505812 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccnc(O)c3)cc2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 266250 US9718790, I-1440 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266250 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266250&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019945 377005122 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505813 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(CCCCC(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C24H26Cl2N4O5/c1-15(2)35-20-11-10-18(13-19(20)26)27-22-28-23(33)29(12-4-3-5-21(31)32)24(34)30(22)14-16-6-8-17(25)9-7-16/h6-11,13,15H,3-5,12,14H2,1-2H3,(H,31,32)(H,27,28,33) NWTHGEAXMFTHOM-UHFFFAOYSA-N 266251 US9718790, I-2184 P2X purinoceptor 3 Homo sapiens 10.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266251 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266251&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020556 377005123 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505814 CCOC(=O)c1nc(Cn2c(=O)[nH]\c(=N/c3ccc(OC(C)C)c(C)c3)n(Cc3ccc(Cl)cc3)c2=O)cs1 InChI=1S/C27H28ClN5O5S/c1-5-37-24(34)23-29-21(15-39-23)14-33-26(35)31-25(30-20-10-11-22(17(4)12-20)38-16(2)3)32(27(33)36)13-18-6-8-19(28)9-7-18/h6-12,15-16H,5,13-14H2,1-4H3,(H,30,31,35) KRNIOXKBZDIIMJ-UHFFFAOYSA-N 266252 US9718790, I-0785 P2X purinoceptor 3 Homo sapiens 11.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266252 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266252&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019873 377005124 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505815 OC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccnc(O)c3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H20ClN5O6/c25-16-3-1-15(2-4-16)14-30-22(28-23(34)29(24(30)35)12-10-21(32)33)27-17-5-7-18(8-6-17)36-19-9-11-26-20(31)13-19/h1-9,11,13H,10,12,14H2,(H,26,31)(H,32,33)(H,27,28,34) LPEWFIYZTNCKRI-UHFFFAOYSA-N 266253 US9718790, I-1441 P2X purinoceptor 3 Homo sapiens 9.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266253 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266253&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020463 377005125 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505816 CCc1nc2ccc(cc2s1)\N=c1/[nH]c(=O)n(CCCCC(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C24H24ClN5O4S/c1-2-20-27-18-11-10-17(13-19(18)35-20)26-22-28-23(33)29(12-4-3-5-21(31)32)24(34)30(22)14-15-6-8-16(25)9-7-15/h6-11,13H,2-5,12,14H2,1H3,(H,31,32)(H,26,28,33) LKSXLAYXUBLCCP-UHFFFAOYSA-N 266254 US9718790, I-2185 P2X purinoceptor 3 Homo sapiens 15.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266254 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266254&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020641 377005126 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505817 CNC(=O)CCCn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H30ClN5O4/c1-16(2)35-21-12-11-20(14-17(21)3)28-23-29-24(33)30(13-5-6-22(32)27-4)25(34)31(23)15-18-7-9-19(26)10-8-18/h7-12,14,16H,5-6,13,15H2,1-4H3,(H,27,32)(H,28,29,33) VRVPUPXRBKHIRB-UHFFFAOYSA-N 266255 US9718790, I-0786 P2X purinoceptor 3 Homo sapiens 15.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266255 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266255&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020785 377005127 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505818 CC(C)Cc1ccc(cc1Cl)\N=c1/[nH]c(=O)n([C@@H](C)[C@@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 266256 US9718790, I-1442 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266256 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266256&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020453 377005128 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505819 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccnc(c3)C(=O)OC)cc2)n(Cc2ccc(Cl)cn2)c1=O InChI=1S/C24H21ClN6O5/c1-3-30-23(33)29-22(31(24(30)34)14-17-5-4-15(25)13-27-17)28-16-6-8-18(9-7-16)36-19-10-11-26-20(12-19)21(32)35-2/h4-13H,3,14H2,1-2H3,(H,28,29,33) CSJQAECZFPHQKZ-UHFFFAOYSA-N 266257 US9718790, I-2186 P2X purinoceptor 3 Homo sapiens 104 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266257 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266257&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021023 377005129 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505820 CC(C)Oc1ccc(cc1C)\N=c1/[nH]c(=O)n(CCCC(=O)N2CCOCC2)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C28H34ClN5O5/c1-19(2)39-24-11-10-23(17-20(24)3)30-26-31-27(36)33(12-4-5-25(35)32-13-15-38-16-14-32)28(37)34(26)18-21-6-8-22(29)9-7-21/h6-11,17,19H,4-5,12-16,18H2,1-3H3,(H,30,31,36) MJXQMIVXJUECQG-UHFFFAOYSA-N 266258 US9718790, I-0787 P2X purinoceptor 3 Homo sapiens 24.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266258 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266258&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020782 377005130 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505821 CC(C)Cc1ccc(cc1Cl)\N=c1/[nH]c(=O)n([C@@H](C)[C@@H](C)C(O)=O)c(=O)n1Cc1ccc(C)cc1 266259 US9718790, I-1443 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266259 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266259&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278339 377005131 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505822 CCOC(=O)c1cnc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(CC)c(=O)n2Cc2ccc(Cl)cc2)o1 InChI=1S/C24H22ClN5O6/c1-3-29-22(32)28-21(30(24(29)33)14-15-5-7-16(25)8-6-15)27-17-9-11-18(12-10-17)35-23-26-13-19(36-23)20(31)34-4-2/h5-13H,3-4,14H2,1-2H3,(H,27,28,32) ZIOQDHBWHADXOE-UHFFFAOYSA-N 266260 US9718790, I-2187 P2X purinoceptor 3 Homo sapiens 44.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266260 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266260&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945585 377005132 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505823 CC(C)Oc1ccc(cc1C)\N=c1/[nH]c(=O)n(CCCC(=O)NCCO)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C26H32ClN5O5/c1-17(2)37-22-11-10-21(15-18(22)3)29-24-30-25(35)31(13-4-5-23(34)28-12-14-33)26(36)32(24)16-19-6-8-20(27)9-7-19/h6-11,15,17,33H,4-5,12-14,16H2,1-3H3,(H,28,34)(H,29,30,35) FUSVHYGSAUXBQR-UHFFFAOYSA-N 266261 US9718790, I-0788 P2X purinoceptor 3 Homo sapiens 32.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266261 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266261&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020776 377005133 C04080 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505824 CC(C)Cc1ccc(cc1Cl)\N=c1/[nH]c(=O)n([C@H](C)[C@H](C)C(O)=O)c(=O)n1Cc1ccc(C)cc1 266262 US9718790, I-1444 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266262 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266262&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020458 377005134 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505825 CCOC(=O)c1coc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(CC)c(=O)n2Cc2ccc(Cl)cc2)n1 InChI=1S/C24H22ClN5O6/c1-3-29-22(32)28-21(30(24(29)33)13-15-5-7-16(25)8-6-15)26-17-9-11-18(12-10-17)36-23-27-19(14-35-23)20(31)34-4-2/h5-12,14H,3-4,13H2,1-2H3,(H,26,28,32) WSAOOCHUKSYRGD-UHFFFAOYSA-N 266263 US9718790, I-2188 P2X purinoceptor 3 Homo sapiens 9.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266263 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266263&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278649 377005135 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505826 COCCOc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 266264 US9718790, I-0789 P2X purinoceptor 3 Homo sapiens 181 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266264 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266264&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020778 377005136 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505827 CC(C)Cc1ccc(cc1Cl)\N=c1/[nH]c(=O)n([C@H](C)[C@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 266265 US9718790, I-1445 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266265 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266265&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020509 377005137 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505828 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ncc(o3)C(O)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C22H18ClN5O6/c1-2-27-20(31)26-19(28(22(27)32)12-13-3-5-14(23)6-4-13)25-15-7-9-16(10-8-15)33-21-24-11-17(34-21)18(29)30/h3-11H,2,12H2,1H3,(H,29,30)(H,25,26,31) OXAZHNXGYGAVRX-UHFFFAOYSA-N 266206 US9718790, I-2189 P2X purinoceptor 3 Homo sapiens 47.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266206 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266206&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278429 377005078 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505829 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc3nc(C)ccc3c2)n(Cc2ccc(Cl)cc2)c1=O 266266 US9718790, I-0790 P2X purinoceptor 3 Homo sapiens 13.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266266 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266266&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020780 377005138 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505830 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(CC(C)C)c(Cl)c2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C27H33ClN4O4/c1-17(2)13-20-11-12-21(14-22(20)28)29-24-30-25(34)32(16-27(4,5)23(33)36-6)26(35)31(24)15-19-9-7-18(3)8-10-19/h7-12,14,17H,13,15-16H2,1-6H3,(H,29,30,34) DZMDITBCOZBHOQ-UHFFFAOYSA-N 266267 US9718790, I-1447 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266267 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266267&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945540 377005139 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505831 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3nc(co3)C(O)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C22H18ClN5O6/c1-2-27-20(31)26-19(28(22(27)32)11-13-3-5-14(23)6-4-13)24-15-7-9-16(10-8-15)34-21-25-17(12-33-21)18(29)30/h3-10,12H,2,11H2,1H3,(H,29,30)(H,24,26,31) KHVPCKNGGIDNIK-UHFFFAOYSA-N 266268 US9718790, I-2190 P2X purinoceptor 3 Homo sapiens 33.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266268 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266268&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021026 377005140 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505832 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc3CCCCc3c2)n(Cc2ccc(Cl)cc2)c1=O 266269 US9718790, I-0791 P2X purinoceptor 3 Homo sapiens 266 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266269 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266269&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019821 377005141 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505833 CCOC(=O)C1(Cn2c(=O)[nH]\c(=N/c3ccc(CC(C)C)c(Cl)c3)n(Cc3ccc(C)cc3)c2=O)CC1 InChI=1S/C28H33ClN4O4/c1-5-37-24(34)28(12-13-28)17-33-26(35)31-25(30-22-11-10-21(14-18(2)3)23(29)15-22)32(27(33)36)16-20-8-6-19(4)7-9-20/h6-11,15,18H,5,12-14,16-17H2,1-4H3,(H,30,31,35) ZMGBUKRMUCXBBR-UHFFFAOYSA-N 266270 US9718790, I-1448 P2X purinoceptor 3 Homo sapiens 12.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266270 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266270&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019925 377005142 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505834 CCOC(=O)c1csc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(CC)c(=O)n2Cc2ccc(Cl)cc2)n1 InChI=1S/C24H22ClN5O5S/c1-3-29-22(32)28-21(30(24(29)33)13-15-5-7-16(25)8-6-15)26-17-9-11-18(12-10-17)35-23-27-19(14-36-23)20(31)34-4-2/h5-12,14H,3-4,13H2,1-2H3,(H,26,28,32) AWDJPBUUZAEBNL-UHFFFAOYSA-N 266271 US9718790, I-2191 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266271 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266271&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945399 377005143 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505835 CC(C)c1cccc(c1)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 266272 US9718790, I-0792 P2X purinoceptor 3 Homo sapiens 170 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266272 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266272&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019795 377005144 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505836 CCOC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(Cl)c2)n(CC2CCC3(CC3)CC2)c1=O InChI=1S/C26H35ClN4O5/c1-4-35-22(32)9-14-30-24(33)29-23(28-19-5-6-21(20(27)15-19)36-17(2)3)31(25(30)34)16-18-7-10-26(11-8-18)12-13-26/h5-6,15,17-18H,4,7-14,16H2,1-3H3,(H,28,29,33) IKXFSRVQVLRLMW-UHFFFAOYSA-N 266273 US9718790, I-1449 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266273 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266273&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019929 377005145 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505837 CCOC(=O)c1cc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(CC)c(=O)n2Cc2ccc(Cl)cc2)[nH]n1 InChI=1S/C24H23ClN6O5/c1-3-30-23(33)27-22(31(24(30)34)14-15-5-7-16(25)8-6-15)26-17-9-11-18(12-10-17)36-20-13-19(28-29-20)21(32)35-4-2/h5-13H,3-4,14H2,1-2H3,(H,28,29)(H,26,27,33) WKYTZSDXMPFXSP-UHFFFAOYSA-N 266274 US9718790, I-2192 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266274 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266274&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945435 377005146 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505838 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccccc1 266275 US9718790, I-0794 P2X purinoceptor 3 Homo sapiens 168 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266275 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266275&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019702 377005147 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505839 CC(C)Oc1ccc(NC(=O)CCn2c(=O)[nH]\c(=N/c3ccc(OC(C)C)c(Cl)c3)n(CC3CCC4(CC4)CC3)c2=O)cc1Cl InChI=1S/C33H41Cl2N5O5/c1-20(2)44-27-7-5-23(17-25(27)34)36-29(41)11-16-39-31(42)38-30(37-24-6-8-28(26(35)18-24)45-21(3)4)40(32(39)43)19-22-9-12-33(13-10-22)14-15-33/h5-8,17-18,20-22H,9-16,19H2,1-4H3,(H,36,41)(H,37,38,42) DFQGSNZKOFLTJK-UHFFFAOYSA-N 266276 US9718790, I-1450 P2X purinoceptor 3 Homo sapiens 448 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266276 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266276&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945181 377005148 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505840 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3nc(cs3)C(O)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C22H18ClN5O5S/c1-2-27-20(31)26-19(28(22(27)32)11-13-3-5-14(23)6-4-13)24-15-7-9-16(10-8-15)33-21-25-17(12-34-21)18(29)30/h3-10,12H,2,11H2,1H3,(H,29,30)(H,24,26,31) HLEWVIORSFMGHF-UHFFFAOYSA-N 266277 US9718790, I-2193 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266277 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266277&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945665 377005149 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505841 CC(C)Oc1ccc(cc1C)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccccc1 266278 US9718790, I-0795 P2X purinoceptor 3 Homo sapiens 724 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266278 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266278&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019796 377005150 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505842 CC(C)Cc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(CC2(CC2)C(O)=O)c(=O)n1Cc1ccc(C)cc1 InChI=1S/C26H29ClN4O4/c1-16(2)12-19-8-9-20(13-21(19)27)28-23-29-24(34)31(15-26(10-11-26)22(32)33)25(35)30(23)14-18-6-4-17(3)5-7-18/h4-9,13,16H,10-12,14-15H2,1-3H3,(H,32,33)(H,28,29,34) BXTGBHOWCBAVFD-UHFFFAOYSA-N 266279 US9718790, I-1451 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266279 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266279&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278261 377005151 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505843 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cc(n[nH]3)C(O)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C22H19ClN6O5/c1-2-28-21(32)25-20(29(22(28)33)12-13-3-5-14(23)6-4-13)24-15-7-9-16(10-8-15)34-18-11-17(19(30)31)26-27-18/h3-11H,2,12H2,1H3,(H,26,27)(H,30,31)(H,24,25,32) IYHIAVXTDNVDNT-UHFFFAOYSA-N 266280 US9718790, I-2194 P2X purinoceptor 3 Homo sapiens 52.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266280 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266280&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020275 377005152 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505844 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(OC)c(c2)C(F)(F)F)n(Cc2ccc(Cl)cc2)c1=O 266281 US9718790, I-0796 P2X purinoceptor 3 Homo sapiens 386 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266281 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266281&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020798 377005153 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505845 COC(=O)[C@@H](C)[C@@H](C)n1c(=O)[nH]\c(=N/c2ccc(OC3CCC3)cc2)n(Cc2ccc(Cl)cc2)c1=O 266282 US9718790, I-1452 P2X purinoceptor 3 Homo sapiens 14.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266282 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266282&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021030 377005154 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505846 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc4ocnc34)c(Cl)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H19Cl2N5O4/c1-2-31-24(33)30-23(32(25(31)34)13-15-6-8-16(26)9-7-15)29-17-10-11-19(18(27)12-17)36-21-5-3-4-20-22(21)28-14-35-20/h3-12,14H,2,13H2,1H3,(H,29,30,33) HERVZUUVQPXDRE-UHFFFAOYSA-N 266283 US9718790, I-2195 P2X purinoceptor 3 Homo sapiens 14.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266283 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266283&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945638 377005155 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505847 COc1ccc(cc1C(F)(F)F)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 266284 US9718790, I-0797 P2X purinoceptor 3 Homo sapiens 701 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266284 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266284&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020800 377005156 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505848 COC(=O)[C@@H](C)[C@@H](C)n1c(=O)[nH]\c(=N/c2ccc(OC3CCC3)cc2)n(Cc2ccc(C)cc2)c1=O 266285 US9718790, I-1453 P2X purinoceptor 3 Homo sapiens 13.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266285 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266285&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945287 377005157 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505849 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc4[nH]ncc34)c(Cl)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H20Cl2N6O3/c1-2-32-24(34)30-23(33(25(32)35)14-15-6-8-16(26)9-7-15)29-17-10-11-22(19(27)12-17)36-21-5-3-4-20-18(21)13-28-31-20/h3-13H,2,14H2,1H3,(H,28,31)(H,29,30,34) JKQHTUAZSJKLPF-UHFFFAOYSA-N 266286 US9718790, I-2196 P2X purinoceptor 3 Homo sapiens 446 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266286 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266286&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130279158 377005158 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505850 CC[C@@H](CC(O)=O)n1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O 266287 US9718790, I-0798 P2X purinoceptor 3 Homo sapiens 465 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266287 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266287&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020804 377005159 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505851 COC(=O)[C@@H](C)[C@@H](C)n1c(=O)[nH]\c(=N/c2ccc(cc2)N2CCCCC2)n(Cc2ccc(Cl)cc2)c1=O 266288 US9718790, I-1454 P2X purinoceptor 3 Homo sapiens 23.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266288 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266288&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278340 377005160 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505852 CCn1c(=O)[nH]\c(=N/c2ccc(OCCN(C)C(C)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H26ClN5O4/c1-4-28-22(31)26-21(29(23(28)32)15-17-5-7-18(24)8-6-17)25-19-9-11-20(12-10-19)33-14-13-27(3)16(2)30/h5-12H,4,13-15H2,1-3H3,(H,25,26,31) JVJYQESXKNXATF-UHFFFAOYSA-N 266289 US9718790, I-2197 P2X purinoceptor 3 Homo sapiens 215 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266289 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266289&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278328 377005161 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505853 CC[C@H](CC(O)=O)n1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O 266290 US9718790, I-0799 P2X purinoceptor 3 Homo sapiens 281 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266290 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266290&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945023 377005162 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505854 COC(=O)[C@@H](C)[C@@H](C)n1c(=O)[nH]\c(=N/c2ccc(cc2)N2CCCCC2)n(Cc2ccc(C)cc2)c1=O 266291 US9718790, I-1455 P2X purinoceptor 3 Homo sapiens 32.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266291 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266291&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945536 377005163 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505855 CCn1c(=O)[nH]\c(=N/c2ccc(OCc3nnc(C)o3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C22H21ClN6O4/c1-3-28-21(30)25-20(29(22(28)31)12-15-4-6-16(23)7-5-15)24-17-8-10-18(11-9-17)32-13-19-27-26-14(2)33-19/h4-11H,3,12-13H2,1-2H3,(H,24,25,30) PTQIRNZBYRCUNF-UHFFFAOYSA-N 266292 US9718790, I-2199 P2X purinoceptor 3 Homo sapiens 515 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266292 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266292&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945621 377005164 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505856 CC(C)Oc1ccc(cc1C)\N=c1/[nH]c(=O)n(Cc2nc(co2)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C25H24ClN5O6/c1-14(2)37-20-9-8-18(10-15(20)3)27-23-29-24(34)31(12-21-28-19(13-36-21)22(32)33)25(35)30(23)11-16-4-6-17(26)7-5-16/h4-10,13-14H,11-12H2,1-3H3,(H,32,33)(H,27,29,34) GRODESAQRKUJSY-UHFFFAOYSA-N 266293 US9718790, I-0800 P2X purinoceptor 3 Homo sapiens 21.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266293 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266293&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020801 377005165 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505857 C[C@@H]([C@@H](C)n1c(=O)[nH]\c(=N/c2ccc(OC3CCC3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 266294 US9718790, I-1456 P2X purinoceptor 3 Homo sapiens 14.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266294 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266294&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945411 377005166 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505858 CCn1c(=O)[nH]\c(=N/c2ccc(OCc3noc(C)n3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C22H21ClN6O4/c1-3-28-21(30)26-20(29(22(28)31)12-15-4-6-16(23)7-5-15)25-17-8-10-18(11-9-17)32-13-19-24-14(2)33-27-19/h4-11H,3,12-13H2,1-2H3,(H,25,26,30) TVWWEPQMOMLKDZ-UHFFFAOYSA-N 266295 US9718790, I-2200 P2X purinoceptor 3 Homo sapiens 545 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266295 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266295&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945706 377005167 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505859 CC(C)Oc1ccc(cc1C)\N=c1/[nH]c(=O)n(Cc2cccc(n2)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C27H26ClN5O5/c1-16(2)38-23-12-11-20(13-17(23)3)30-25-31-26(36)33(15-21-5-4-6-22(29-21)24(34)35)27(37)32(25)14-18-7-9-19(28)10-8-18/h4-13,16H,14-15H2,1-3H3,(H,34,35)(H,30,31,36) LTYQNNBAGQKYPR-UHFFFAOYSA-N 266296 US9718790, I-0801 P2X purinoceptor 3 Homo sapiens 10.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266296 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266296&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020982 377005168 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505860 C[C@@H]([C@@H](C)n1c(=O)[nH]\c(=N/c2ccc(OC3CCC3)cc2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 266297 US9718790, I-1457 P2X purinoceptor 3 Homo sapiens 14.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266297 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266297&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278194 377005169 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505861 CCn1c(=O)[nH]\c(=N/c2ccc(OCCc3ccccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H24ClN5O3/c1-2-30-24(32)29-23(31(25(30)33)17-18-6-8-19(26)9-7-18)28-21-10-12-22(13-11-21)34-16-14-20-5-3-4-15-27-20/h3-13,15H,2,14,16-17H2,1H3,(H,28,29,32) FRXYIOFREWPKCL-UHFFFAOYSA-N 266298 US9718790, I-2201 P2X purinoceptor 3 Homo sapiens 92.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266298 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266298&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021028 377005170 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505862 CC(C)Oc1ccc(cc1C)\N=c1/[nH]c(=O)n(Cc2cc(no2)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C25H24ClN5O6/c1-14(2)36-21-9-8-18(10-15(21)3)27-23-28-24(34)31(13-19-11-20(22(32)33)29-37-19)25(35)30(23)12-16-4-6-17(26)7-5-16/h4-11,14H,12-13H2,1-3H3,(H,32,33)(H,27,28,34) CRGHUMKXOTUILR-UHFFFAOYSA-N 266299 US9718790, I-0802 P2X purinoceptor 3 Homo sapiens 21.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266299 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266299&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020987 377005171 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505863 C[C@@H]([C@@H](C)n1c(=O)[nH]\c(=N/c2ccc(cc2)N2CCCCC2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 266300 US9718790, I-1458 P2X purinoceptor 3 Homo sapiens 25.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266300 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266300&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945310 377005172 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505864 CCCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(nc3)C(N)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H23ClN6O4/c1-2-13-31-24(34)30-23(32(25(31)35)15-16-3-5-17(26)6-4-16)29-18-7-9-19(10-8-18)36-20-11-12-21(22(27)33)28-14-20/h3-12,14H,2,13,15H2,1H3,(H2,27,33)(H,29,30,34) OVQKGZVXMSQNCM-UHFFFAOYSA-N 266301 US9718790, I-2203 P2X purinoceptor 3 Homo sapiens 1.000 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266301 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266301&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945667 377005173 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505865 CC(C)Oc1ccc(cc1C)\N=c1/[nH]c(=O)n(c(=O)n1Cc1ccc(Cl)cc1)C(C)(C)CC(O)=O InChI=1S/C25H29ClN4O5/c1-15(2)35-20-11-10-19(12-16(20)3)27-22-28-23(33)30(25(4,5)13-21(31)32)24(34)29(22)14-17-6-8-18(26)9-7-17/h6-12,15H,13-14H2,1-5H3,(H,31,32)(H,27,28,33) RNYAZYVEVGKQMK-UHFFFAOYSA-N 266302 US9718790, I-0804 P2X purinoceptor 3 Homo sapiens 132 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266302 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266302&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020983 377005174 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505866 C[C@@H]([C@@H](C)n1c(=O)[nH]\c(=N/c2ccc(cc2)N2CCCCC2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 266303 US9718790, I-1459 P2X purinoceptor 3 Homo sapiens 34.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266303 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266303&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278585 377005175 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505867 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cncc(c3)C(=O)OC)cc2)n(CC2CCC(C)(C)CC2)c1=O InChI=1S/C27H33N5O5/c1-5-31-25(34)30-24(32(26(31)35)17-18-10-12-27(2,3)13-11-18)29-20-6-8-21(9-7-20)37-22-14-19(15-28-16-22)23(33)36-4/h6-9,14-16,18H,5,10-13,17H2,1-4H3,(H,29,30,34) DQHGYKATSWKFTF-UHFFFAOYSA-N 266304 US9718790, I-2204 P2X purinoceptor 3 Homo sapiens 28.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266304 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266304&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021070 377005176 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505868 CCOC(=O)CC(C)(C)n1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C27H33ClN4O5/c1-7-36-23(33)15-27(5,6)32-25(34)30-24(29-21-12-13-22(18(4)14-21)37-17(2)3)31(26(32)35)16-19-8-10-20(28)11-9-19/h8-14,17H,7,15-16H2,1-6H3,(H,29,30,34) PMPSMPDQSCQDDR-UHFFFAOYSA-N 266305 US9718790, I-0805 P2X purinoceptor 3 Homo sapiens 29.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266305 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266305&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020971 377005177 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505869 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(cc2)C2CC2)n(Cc2ccc(C)cc2)c1=O 266306 US9718790, I-1460 P2X purinoceptor 3 Homo sapiens 272 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266306 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266306&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020302 377005178 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505870 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccnc(c3)C(=O)OC)cc2)n(CC2CCC(C)(C)CC2)c1=O InChI=1S/C27H33N5O5/c1-5-31-25(34)30-24(32(26(31)35)17-18-10-13-27(2,3)14-11-18)29-19-6-8-20(9-7-19)37-21-12-15-28-22(16-21)23(33)36-4/h6-9,12,15-16,18H,5,10-11,13-14,17H2,1-4H3,(H,29,30,34) ADSDBFLXVWDOPC-UHFFFAOYSA-N 266307 US9718790, I-2205 P2X purinoceptor 3 Homo sapiens 9.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266307 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266307&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278230 377005179 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505871 CO[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O)C(=O)OC 266308 US9718790, I-0806 P2X purinoceptor 3 Homo sapiens 12.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266308 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266308&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019550 377005180 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505872 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(CCC(O)=O)c(=O)n1CC1CCC2(CC2)CC1 InChI=1S/C24H31ClN4O5/c1-15(2)34-19-4-3-17(13-18(19)25)26-21-27-22(32)28(12-7-20(30)31)23(33)29(21)14-16-5-8-24(9-6-16)10-11-24/h3-4,13,15-16H,5-12,14H2,1-2H3,(H,30,31)(H,26,27,32) POZLIQHYJHVLRD-UHFFFAOYSA-N 266309 US9718790, I-1461 P2X purinoceptor 3 Homo sapiens 25.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266309 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266309&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021073 377005181 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505873 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cc(ncn3)C(=O)OC)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H21ClN6O5/c1-3-30-23(33)29-22(31(24(30)34)13-15-4-6-16(25)7-5-15)28-17-8-10-18(11-9-17)36-20-12-19(21(32)35-2)26-14-27-20/h4-12,14H,3,13H2,1-2H3,(H,28,29,33) IPGXPPKZGWGBGV-UHFFFAOYSA-N 266310 US9718790, I-2206 P2X purinoceptor 3 Homo sapiens 12.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266310 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266310&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278430 377005182 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505874 CO[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 266311 US9718790, I-0807 P2X purinoceptor 3 Homo sapiens 13.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266311 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266311&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019560 377005183 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505875 CC(C)Cc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n1Cc1ccc(C)cc1 InChI=1S/C26H31ClN4O4/c1-16(2)12-19-10-11-20(13-21(19)27)28-23-29-24(34)31(15-26(4,5)22(32)33)25(35)30(23)14-18-8-6-17(3)7-9-18/h6-11,13,16H,12,14-15H2,1-5H3,(H,32,33)(H,28,29,34) VAIQRRFBYXQBGZ-UHFFFAOYSA-N 266312 US9718790, I-1462 P2X purinoceptor 3 Homo sapiens 3.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266312 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266312&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278341 377005184 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505876 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cncc(c3)C(O)=O)cc2)n(CC2CCC(C)(C)CC2)c1=O InChI=1S/C26H31N5O5/c1-4-30-24(34)29-23(31(25(30)35)16-17-9-11-26(2,3)12-10-17)28-19-5-7-20(8-6-19)36-21-13-18(22(32)33)14-27-15-21/h5-8,13-15,17H,4,9-12,16H2,1-3H3,(H,32,33)(H,28,29,34) BKZJCBQBYDLOMQ-UHFFFAOYSA-N 266313 US9718790, I-2207 P2X purinoceptor 3 Homo sapiens 69.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266313 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266313&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945579 377005185 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505877 CC(C)Oc1ccc(cc1C)\N=c1/[nH]c(=O)n([C@@H]2CCOC2=O)c(=O)n1Cc1ccc(Cl)cc1 266314 US9718790, I-0808 P2X purinoceptor 3 Homo sapiens 203 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266314 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266314&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118944985 377005186 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505878 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(C3CC3)c(Cl)c2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 266315 US9718790, I-1463::US9718790, I-1489 P2X purinoceptor 3 Homo sapiens 632 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266315 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266315&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019713 377005187 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505879 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccnc(c3)C(O)=O)cc2)n(CC2CCC(C)(C)CC2)c1=O InChI=1S/C26H31N5O5/c1-4-30-24(34)29-23(31(25(30)35)16-17-9-12-26(2,3)13-10-17)28-18-5-7-19(8-6-18)36-20-11-14-27-21(15-20)22(32)33/h5-8,11,14-15,17H,4,9-10,12-13,16H2,1-3H3,(H,32,33)(H,28,29,34) FLUDMNGKVISTPE-UHFFFAOYSA-N 266316 US9718790, I-2208 P2X purinoceptor 3 Homo sapiens 12.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266316 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266316&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021029 377005188 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505880 COC(=O)[C@H](C)[C@H](C)n1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O 266317 US9718790, I-0809 P2X purinoceptor 3 Homo sapiens 34.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266317 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266317&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019529 377005189 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505881 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(CC(C)C)c(Cl)c2)n(Cc2ccc(C)nc2)c1=O 266318 US9718790, I-1464 P2X purinoceptor 3 Homo sapiens 70.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266318 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266318&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945548 377005190 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505882 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cc(ncn3)C(O)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H19ClN6O5/c1-2-29-22(33)28-21(30(23(29)34)12-14-3-5-15(24)6-4-14)27-16-7-9-17(10-8-16)35-19-11-18(20(31)32)25-13-26-19/h3-11,13H,2,12H2,1H3,(H,31,32)(H,27,28,33) GOXSCOHGFJWVRZ-UHFFFAOYSA-N 266319 US9718790, I-2209 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266319 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266319&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945626 377005191 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505883 CCOC(=O)CC(C)(C)n1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(Cl)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H30Cl2N4O5/c1-6-36-22(33)14-26(4,5)32-24(34)30-23(29-19-11-12-21(20(28)13-19)37-16(2)3)31(25(32)35)15-17-7-9-18(27)10-8-17/h7-13,16H,6,14-15H2,1-5H3,(H,29,30,34) GKQFPFSDSXVKJQ-UHFFFAOYSA-N 266320 US9718790, I-0810 P2X purinoceptor 3 Homo sapiens 16.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266320 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266320&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019561 377005192 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505884 CCc1oc2ccc(cc2c1C)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 266321 US9718790, I-1465 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266321 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266321&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021124 377005193 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505885 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cc(nc(Cl)n3)C(=O)OC)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H20Cl2N6O5/c1-3-31-23(34)30-22(32(24(31)35)13-14-4-6-15(25)7-5-14)27-16-8-10-17(11-9-16)37-19-12-18(20(33)36-2)28-21(26)29-19/h4-12H,3,13H2,1-2H3,(H,27,30,34) WHKQTWGZVVPSKJ-UHFFFAOYSA-N 266322 US9718790, I-2210 P2X purinoceptor 3 Homo sapiens 14.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266322 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266322&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278611 377005194 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505886 COC(=O)[C@@H](C)[C@@H](C)n1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O 266323 US9718790, I-0811 P2X purinoceptor 3 Homo sapiens 40.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266323 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266323&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278531 377005195 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505887 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc3OC(C)Cc3c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 266324 US9718790, I-1466 P2X purinoceptor 3 Homo sapiens 121 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266324 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266324&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019610 377005196 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505888 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccnc(c3)C(O)=O)cc2)n(Cc2ccc(Cl)cn2)c1=O InChI=1S/C23H19ClN6O5/c1-2-29-22(33)28-21(30(23(29)34)13-16-4-3-14(24)12-26-16)27-15-5-7-17(8-6-15)35-18-9-10-25-19(11-18)20(31)32/h3-12H,2,13H2,1H3,(H,31,32)(H,27,28,33) HILJQOPXCYIVBO-UHFFFAOYSA-N 266325 US9718790, I-2211 P2X purinoceptor 3 Homo sapiens 14.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266325 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266325&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278650 377005197 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505889 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(OCC(C)C)cc2)n(Cc2ccc(C)cc2)c1=O 266326 US9718790, I-0812 P2X purinoceptor 3 Homo sapiens 33.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266326 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266326&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020169 377005198 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505890 C[C@@H]([C@@H](C)n1c(=O)[nH]\c(=N/c2ccc3nc(C)sc3c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 266327 US9718790, I-1467 P2X purinoceptor 3 Homo sapiens 12.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266327 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266327&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945434 377005199 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505891 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cnc(cn3)C(=O)OC)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H21ClN6O5/c1-3-30-23(33)29-22(31(24(30)34)14-15-4-6-16(25)7-5-15)28-17-8-10-18(11-9-17)36-20-13-26-19(12-27-20)21(32)35-2/h4-13H,3,14H2,1-2H3,(H,28,29,33) PROGVNDCBHEPNU-UHFFFAOYSA-N 266328 US9718790, I-2212 P2X purinoceptor 3 Homo sapiens 2.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266328 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266328&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945613 377005200 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505892 CCc1ccc(cc1C)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 266329 US9718790, I-0818 P2X purinoceptor 3 Homo sapiens 18.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266329 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266329&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019896 377005201 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505893 C[C@@H]([C@@H](C)n1c(=O)[nH]\c(=N/c2ccc3nc(C)sc3c2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 266330 US9718790, I-1468 P2X purinoceptor 3 Homo sapiens 10.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266330 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266330&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019746 377005202 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505894 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccnc(NC(=O)NC4CC4)c3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C27H26ClN7O4/c1-2-34-26(37)33-24(35(27(34)38)16-17-3-5-18(28)6-4-17)30-19-9-11-21(12-10-19)39-22-13-14-29-23(15-22)32-25(36)31-20-7-8-20/h3-6,9-15,20H,2,7-8,16H2,1H3,(H,30,33,37)(H2,29,31,32,36) PUUFMHQZCPQYRZ-UHFFFAOYSA-N 266331 US9718790, I-2213 P2X purinoceptor 3 Homo sapiens 2.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266331 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266331&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021160 377005203 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505895 CCCCOc1ccc(cc1)\N=c1/[nH]c(=O)n(C[C@H](C)C(=O)OC)c(=O)n1Cc1ccc(Cl)cc1 266332 US9718790, I-0814 P2X purinoceptor 3 Homo sapiens 17.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266332 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266332&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020170 377005204 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505896 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc3nc(C)sc3c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 266333 US9718790, I-1469 P2X purinoceptor 3 Homo sapiens 9.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266333 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266333&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278586 377005205 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505897 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(N)nc3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H21ClN6O3/c1-2-29-22(31)28-21(30(23(29)32)14-15-3-5-16(24)6-4-15)27-17-7-9-18(10-8-17)33-19-11-12-20(25)26-13-19/h3-13H,2,14H2,1H3,(H2,25,26)(H,27,28,31) JJVMTMSFJSWDNR-UHFFFAOYSA-N 266334 US9718790, I-2214 P2X purinoceptor 3 Homo sapiens 22.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266334 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266334&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021153 377005206 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505898 CCc1ccc(cc1C)\N=c1/[nH]c(=O)n(C[C@H](C)C(=O)OC)c(=O)n1Cc1ccc(Cl)cc1 266335 US9718790, I-0815 P2X purinoceptor 3 Homo sapiens 189 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266335 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266335&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020085 377005207 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505899 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc3nc(C)sc3c2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 266336 US9718790, I-1470 P2X purinoceptor 3 Homo sapiens 10.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266336 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266336&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945304 377005208 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505900 OC(=O)c1cncc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(CC(F)F)c(=O)n2Cc2ccc(Cl)cc2)c1 InChI=1S/C24H18ClF2N5O5/c25-16-3-1-14(2-4-16)12-31-22(30-23(35)32(24(31)36)13-20(26)27)29-17-5-7-18(8-6-17)37-19-9-15(21(33)34)10-28-11-19/h1-11,20H,12-13H2,(H,33,34)(H,29,30,35) QQXPGQFCLLVNKK-UHFFFAOYSA-N 266337 US9718790, I-2215 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266337 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266337&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278343 377005209 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505901 CCCCOc1ccc(cc1)\N=c1/[nH]c(=O)n(C[C@H](C)C(=O)OC)c(=O)n1Cc1ccc(C)cc1 266338 US9718790, I-0816 P2X purinoceptor 3 Homo sapiens 37.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266338 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266338&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019736 377005210 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505902 CCc1nc2ccc(cc2s1)\N=c1/[nH]c(=O)n([C@@H](C)[C@@H](C)C(O)=O)c(=O)n1Cc1ccc(C)cc1 266339 US9718790, I-1471 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266339 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266339&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278262 377005211 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505903 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccnc(NC(C)=O)c3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H23ClN6O4/c1-3-31-24(34)30-23(32(25(31)35)15-17-4-6-18(26)7-5-17)29-19-8-10-20(11-9-19)36-21-12-13-27-22(14-21)28-16(2)33/h4-14H,3,15H2,1-2H3,(H,27,28,33)(H,29,30,34) RRHXBNJYAMQGEF-UHFFFAOYSA-N 266340 US9718790, I-2216 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266340 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266340&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020648 377005212 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505904 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(c(=O)n1Cc1ccc(Cl)cc1)C(C)(C)CC(O)=O InChI=1S/C24H26Cl2N4O5/c1-14(2)35-19-10-9-17(11-18(19)26)27-21-28-22(33)30(24(3,4)12-20(31)32)23(34)29(21)13-15-5-7-16(25)8-6-15/h5-11,14H,12-13H2,1-4H3,(H,31,32)(H,27,28,33) RBWOUNOUKRKBSO-UHFFFAOYSA-N 266341 US9718790, I-0817 P2X purinoceptor 3 Homo sapiens 27.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266341 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266341&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019637 377005213 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505905 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc3nc(C)sc3c2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 266342 US9718790, I-1473 P2X purinoceptor 3 Homo sapiens 12.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266342 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266342&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945427 377005214 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505906 CCC(=O)Nc1cc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(CC)c(=O)n2Cc2ccc(Cl)cc2)ccn1 InChI=1S/C26H25ClN6O4/c1-3-23(34)30-22-15-21(13-14-28-22)37-20-11-9-19(10-12-20)29-24-31-25(35)32(4-2)26(36)33(24)16-17-5-7-18(27)8-6-17/h5-15H,3-4,16H2,1-2H3,(H,28,30,34)(H,29,31,35) AUXQKDDENFRCGP-UHFFFAOYSA-N 266343 US9718790, I-2217 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266343 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266343&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130279147 377005215 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505907 CCc1ccc(cc1C)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 266329 US9718790, I-0818 P2X purinoceptor 3 Homo sapiens 529 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266329 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266329&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019896 377005201 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505908 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2cnc(Oc3ccccc3)c(Cl)c2)n(Cc2ccc(C)cc2)c1=O 266344 US9718790, I-1474 P2X purinoceptor 3 Homo sapiens 138 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266344 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266344&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278512 377005216 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505909 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(C(=O)OC)c(F)c3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H22ClFN4O5/c1-3-31-25(34)30-24(32(26(31)35)15-16-4-6-17(27)7-5-16)29-18-8-10-19(11-9-18)37-20-12-13-21(22(28)14-20)23(33)36-2/h4-14H,3,15H2,1-2H3,(H,29,30,34) LBTGVYAQXCMFLT-UHFFFAOYSA-N 266345 US9718790, I-2218 P2X purinoceptor 3 Homo sapiens 3.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266345 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266345&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020649 377005217 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505910 CCCCOc1ccc(cc1)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 266346 US9718790, I-0819 P2X purinoceptor 3 Homo sapiens 22.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266346 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266346&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019819 377005218 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505911 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2cnc(OC3CCCC3)c(Cl)c2)n(Cc2ccc(C)cc2)c1=O 266347 US9718790, I-1475 P2X purinoceptor 3 Homo sapiens 39.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266347 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266347&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278587 377005219 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505912 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cc(F)cc(c3)C(=O)OC)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H22ClFN4O5/c1-3-31-25(34)30-24(32(26(31)35)15-16-4-6-18(27)7-5-16)29-20-8-10-21(11-9-20)37-22-13-17(23(33)36-2)12-19(28)14-22/h4-14H,3,15H2,1-2H3,(H,29,30,34) COAOKETUSHHRFC-UHFFFAOYSA-N 266348 US9718790, I-2219 P2X purinoceptor 3 Homo sapiens 14.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266348 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266348&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020558 377005220 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505913 CCCCOc1ccc(cc1)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(C)cc1 266349 US9718790, I-0820 P2X purinoceptor 3 Homo sapiens 35.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266349 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266349&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278465 377005221 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505914 C[C@@H](Cn1c(=O)[nH]\c(=N/c2cnc(Oc3ccccc3)c(Cl)c2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 266350 US9718790, I-1476 P2X purinoceptor 3 Homo sapiens 262 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266350 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266350&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020469 377005222 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505915 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3nc(OC)nc(OC)n3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H22ClN7O5/c1-4-30-22(32)26-18(31(23(30)33)13-14-5-7-15(24)8-6-14)25-16-9-11-17(12-10-16)36-21-28-19(34-2)27-20(29-21)35-3/h5-12H,4,13H2,1-3H3,(H,25,26,32) BCMZYWUXPVTYAG-UHFFFAOYSA-N 266351 US9718790, I-2220 P2X purinoceptor 3 Homo sapiens 37.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266351 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266351&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020611 377005223 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505916 CCCOc1ccc(cc1)\N=c1/[nH]c(=O)n(c(=O)n1Cc1ccc(Cl)cc1)C(C)(C)CC(=O)OCC InChI=1S/C26H31ClN4O5/c1-5-15-36-21-13-11-20(12-14-21)28-23-29-24(33)31(26(3,4)16-22(32)35-6-2)25(34)30(23)17-18-7-9-19(27)10-8-18/h7-14H,5-6,15-17H2,1-4H3,(H,28,29,33) ULHBNUJVXJOFRN-UHFFFAOYSA-N 266352 US9718790, I-0821 P2X purinoceptor 3 Homo sapiens 50.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266352 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266352&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278532 377005224 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505917 C[C@@H](Cn1c(=O)[nH]\c(=N/c2cnc(OC3CCCC3)c(Cl)c2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 266353 US9718790, I-1477 P2X purinoceptor 3 Homo sapiens 68.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266353 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266353&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020460 377005225 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505918 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3nc(O)nc(O)n3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C21H18ClN7O5/c1-2-28-20(32)24-16(29(21(28)33)11-12-3-5-13(22)6-4-12)23-14-7-9-15(10-8-14)34-19-26-17(30)25-18(31)27-19/h3-10H,2,11H2,1H3,(H,23,24,32)(H2,25,26,27,30,31) VNCLIVKTNXOWTG-UHFFFAOYSA-N 266354 US9718790, I-2222 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266354 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266354&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019864 377005226 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505919 CCOC(=O)CC(C)(C)n1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H30ClFN4O5/c1-6-36-22(33)14-26(4,5)32-24(34)30-23(29-19-11-12-21(20(28)13-19)37-16(2)3)31(25(32)35)15-17-7-9-18(27)10-8-17/h7-13,16H,6,14-15H2,1-5H3,(H,29,30,34) BIQHTEXNYYXYSA-UHFFFAOYSA-N 266355 US9718790, I-0822 P2X purinoceptor 3 Homo sapiens 26.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266355 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266355&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278164 377005227 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505920 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2cnc(OC3CCC3)c(C)c2)n(Cc2ccc(C)cc2)c1=O 266356 US9718790, I-1478 P2X purinoceptor 3 Homo sapiens 19.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266356 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266356&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020450 377005228 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505921 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cc(F)cc(c3)C(O)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H20ClFN4O5/c1-2-30-24(34)29-23(31(25(30)35)14-15-3-5-17(26)6-4-15)28-19-7-9-20(10-8-19)36-21-12-16(22(32)33)11-18(27)13-21/h3-13H,2,14H2,1H3,(H,32,33)(H,28,29,34) QSJYFFLEWFKGCS-UHFFFAOYSA-N 266357 US9718790, I-2223 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266357 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266357&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020038 377005229 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505922 CC[C@@H](C)Oc1ccc(cc1C)\N=c1/[nH]c(=O)n(C[C@H](C)C(=O)OC)c(=O)n1Cc1ccc(C)cc1 266358 US9718790, I-0823 P2X purinoceptor 3 Homo sapiens 11.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266358 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266358&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945153 377005230 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505923 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2cnc(OC3CCC3)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O 266359 US9718790, I-1479 P2X purinoceptor 3 Homo sapiens 20.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266359 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266359&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278348 377005231 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505924 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(\C=C\C(=O)OC)c3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C28H25ClN4O5/c1-3-32-27(35)31-26(33(28(32)36)18-20-7-10-21(29)11-8-20)30-22-12-14-23(15-13-22)38-24-6-4-5-19(17-24)9-16-25(34)37-2/h4-17H,3,18H2,1-2H3,(H,30,31,35)/b16-9+ JODRNMIFZXHBAK-CXUHLZMHSA-N 266360 US9718790, I-2224 P2X purinoceptor 3 Homo sapiens 33.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266360 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266360&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945628 377005232 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505925 CC[C@@H](C)Oc1ccc(cc1)\N=c1/[nH]c(=O)n(C[C@H](C)C(=O)OC)c(=O)n1Cc1ccc(C)cc1 266361 US9718790, I-0824 P2X purinoceptor 3 Homo sapiens 18.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266361 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266361&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278466 377005233 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505926 COC(=O)C1(Cn2c(=O)[nH]\c(=N/c3ccc(OC(C)C)c(C)c3)n(Cc3ccc(Cl)cc3)c2=O)COC1 InChI=1S/C26H29ClN4O6/c1-16(2)37-21-10-9-20(11-17(21)3)28-23-29-24(33)31(13-26(14-36-15-26)22(32)35-4)25(34)30(23)12-18-5-7-19(27)8-6-18/h5-11,16H,12-15H2,1-4H3,(H,28,29,33) GKKBLNPCCNASIL-UHFFFAOYSA-N 266362 US9718790, I-1480 P2X purinoceptor 3 Homo sapiens 2.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266362 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266362&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020452 377005234 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505927 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(CCC(=O)OC)c3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C28H27ClN4O5/c1-3-32-27(35)31-26(33(28(32)36)18-20-7-10-21(29)11-8-20)30-22-12-14-23(15-13-22)38-24-6-4-5-19(17-24)9-16-25(34)37-2/h4-8,10-15,17H,3,9,16,18H2,1-2H3,(H,30,31,35) SSPSZJQVMRUGJD-UHFFFAOYSA-N 266363 US9718790, I-2225 P2X purinoceptor 3 Homo sapiens 61.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266363 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266363&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020060 377005235 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505928 CC(C)Oc1ccc(cc1C)\N=c1/[nH]c(=O)n([C@H](C)[C@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 266364 US9718790, I-0825 P2X purinoceptor 3 Homo sapiens 25.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266364 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266364&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020191 377005236 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505929 CC(C)Oc1ccc(cc1C)\N=c1/[nH]c(=O)n(CC2(COC2)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C25H27ClN4O6/c1-15(2)36-20-9-8-19(10-16(20)3)27-22-28-23(33)30(12-25(21(31)32)13-35-14-25)24(34)29(22)11-17-4-6-18(26)7-5-17/h4-10,15H,11-14H2,1-3H3,(H,31,32)(H,27,28,33) AHAPRWLRQVZLLI-UHFFFAOYSA-N 266365 US9718790, I-1481 P2X purinoceptor 3 Homo sapiens 39.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266365 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266365&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945445 377005237 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505930 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(C(O)=O)c(F)c3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H20ClFN4O5/c1-2-30-24(34)29-23(31(25(30)35)14-15-3-5-16(26)6-4-15)28-17-7-9-18(10-8-17)36-19-11-12-20(22(32)33)21(27)13-19/h3-13H,2,14H2,1H3,(H,32,33)(H,28,29,34) QSXHFOFXWGBKGE-UHFFFAOYSA-N 266366 US9718790, I-2226 P2X purinoceptor 3 Homo sapiens 12.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266366 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266366&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945670 377005238 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505931 CC(C)Oc1ccc(cc1C)\N=c1/[nH]c(=O)n([C@@H](C)[C@@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 266367 US9718790, I-0826 P2X purinoceptor 3 Homo sapiens 19.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266367 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266367&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020054 377005239 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505932 C[C@@H](Cn1c(=O)[nH]\c(=N/c2cnc(OC3CCC3)c(C)c2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 266368 US9718790, I-1482 P2X purinoceptor 3 Homo sapiens 98.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266368 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266368&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945389 377005240 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505933 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cc(ccn3)C#N)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H19ClN6O3/c1-2-30-23(32)29-22(31(24(30)33)15-16-3-5-18(25)6-4-16)28-19-7-9-20(10-8-19)34-21-13-17(14-26)11-12-27-21/h3-13H,2,15H2,1H3,(H,28,29,32) KUOFAFWNEPTBIS-UHFFFAOYSA-N 266369 US9718790, I-2227 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266369 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266369&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945710 377005241 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505934 CC(C)COc1ccc(cc1)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(C)cc1 266370 US9718790, I-0827 P2X purinoceptor 3 Homo sapiens 26.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266370 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266370&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945320 377005242 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505935 C[C@@H](Cn1c(=O)[nH]\c(=N/c2cnc(OC3CCC3)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 266371 US9718790, I-1483 P2X purinoceptor 3 Homo sapiens 87.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266371 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266371&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945438 377005243 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505936 Cc1cc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(C[C@@H]3COC(C)(C)O3)c(=O)n2Cc2ccc(Cl)cc2)no1 266372 US9718790, I-2228 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266372 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266372&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945617 377005244 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505937 CCCOc1ccc(cc1)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(C)cc1 266373 US9718790, I-0828 P2X purinoceptor 3 Homo sapiens 25.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266373 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266373&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020405 377005245 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505938 COC(=O)[C@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(cc2)N2CCCCC2)n(Cc2ccc(Cl)cc2)c1=O 266374 US9718790, I-1484 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266374 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266374&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945308 377005246 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505939 Cc1cc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(C[C@@H](O)CO)c(=O)n2Cc2ccc(Cl)cc2)no1 266375 US9718790, I-2229 P2X purinoceptor 3 Homo sapiens 23.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266375 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266375&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945631 377005247 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505940 CCCOc1ccc(cc1)\N=c1/[nH]c(=O)n(c(=O)n1Cc1ccc(Cl)cc1)C(C)(C)CC(O)=O InChI=1S/C24H27ClN4O5/c1-4-13-34-19-11-9-18(10-12-19)26-21-27-22(32)29(24(2,3)14-20(30)31)23(33)28(21)15-16-5-7-17(25)8-6-16/h5-12H,4,13-15H2,1-3H3,(H,30,31)(H,26,27,32) VOBYLYJGRSLMOV-UHFFFAOYSA-N 266376 US9718790, I-0829 P2X purinoceptor 3 Homo sapiens 216 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266376 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266376&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945329 377005248 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505941 CC(C)Cc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(C)nc1 266377 US9718790, I-1485 P2X purinoceptor 3 Homo sapiens 235 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266377 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266377&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945553 377005249 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505942 CCCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(nc3)C#N)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H21ClN6O3/c1-2-13-31-24(33)30-23(32(25(31)34)16-17-3-5-18(26)6-4-17)29-19-7-10-21(11-8-19)35-22-12-9-20(14-27)28-15-22/h3-12,15H,2,13,16H2,1H3,(H,29,30,33) UVUKXDJEOZGJHQ-UHFFFAOYSA-N 266378 US9718790, I-2230 P2X purinoceptor 3 Homo sapiens 2.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266378 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266378&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945377 377005250 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505943 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n(c(=O)n1Cc1ccc(Cl)cc1)C(C)(C)CC(O)=O InChI=1S/C24H26ClFN4O5/c1-14(2)35-19-10-9-17(11-18(19)26)27-21-28-22(33)30(24(3,4)12-20(31)32)23(34)29(21)13-15-5-7-16(25)8-6-15/h5-11,14H,12-13H2,1-4H3,(H,31,32)(H,27,28,33) AONGJCMTKATWMD-UHFFFAOYSA-N 266379 US9718790, I-0830 P2X purinoceptor 3 Homo sapiens 89.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266379 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266379&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945082 377005251 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505944 C[C@H](Cn1c(=O)[nH]\c(=N/c2ccc(cc2)N2CCCCC2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 266380 US9718790, I-1486 P2X purinoceptor 3 Homo sapiens 43.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266380 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266380&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019764 377005252 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505945 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(\C=C\C(O)=O)c3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C27H23ClN4O5/c1-2-31-26(35)30-25(32(27(31)36)17-19-6-9-20(28)10-7-19)29-21-11-13-22(14-12-21)37-23-5-3-4-18(16-23)8-15-24(33)34/h3-16H,2,17H2,1H3,(H,33,34)(H,29,30,35)/b15-8+ JHADFSREWPUDTI-OVCLIPMQSA-N 266381 US9718790, I-2231 P2X purinoceptor 3 Homo sapiens 3.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266381 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266381&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021063 377005253 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505946 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(OCC(C)C)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O 266382 US9718790, I-0831 P2X purinoceptor 3 Homo sapiens 77.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266382 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266382&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945341 377005254 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505947 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(C3CC3)c(Cl)c2)n(Cc2ccc(C)cc2)c1=O 266383 US9718790, I-1487 P2X purinoceptor 3 Homo sapiens 106 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266383 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266383&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019580 377005255 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505948 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(CCC(O)=O)c3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C27H25ClN4O5/c1-2-31-26(35)30-25(32(27(31)36)17-19-6-9-20(28)10-7-19)29-21-11-13-22(14-12-21)37-23-5-3-4-18(16-23)8-15-24(33)34/h3-7,9-14,16H,2,8,15,17H2,1H3,(H,33,34)(H,29,30,35) LQHSJPZTVULMJO-UHFFFAOYSA-N 266384 US9718790, I-2232 P2X purinoceptor 3 Homo sapiens 13.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266384 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266384&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278431 377005256 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505949 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(OCC(C)C)c(C)c2)n(Cc2ccc(C)cc2)c1=O 266385 US9718790, I-0832 P2X purinoceptor 3 Homo sapiens 103 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266385 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266385&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019583 377005257 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505950 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(C3CC3)c(c2)C2CC2)n(Cc2ccc(C)cc2)c1=O 266386 US9718790, I-1488 P2X purinoceptor 3 Homo sapiens 652 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266386 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266386&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019712 377005258 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505951 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cc(F)cc(c3)C(N)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H21ClFN5O4/c1-2-31-24(34)30-23(32(25(31)35)14-15-3-5-17(26)6-4-15)29-19-7-9-20(10-8-19)36-21-12-16(22(28)33)11-18(27)13-21/h3-13H,2,14H2,1H3,(H2,28,33)(H,29,30,34) OIAAYNIWLJLLSJ-UHFFFAOYSA-N 266387 US9718790, I-2233 P2X purinoceptor 3 Homo sapiens 2.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266387 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266387&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021049 377005259 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505952 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(OCC3CC3)cc2)n(Cc2ccc(Cl)cc2)c1=O 266388 US9718790, I-0833 P2X purinoceptor 3 Homo sapiens 15.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266388 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266388&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278283 377005260 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505953 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(C3CC3)c(Cl)c2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 266315 US9718790, I-1463::US9718790, I-1489 P2X purinoceptor 3 Homo sapiens 254 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266315 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266315&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019713 377005187 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505954 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(C(N)=O)c(F)c3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H21ClFN5O4/c1-2-31-24(34)30-23(32(25(31)35)14-15-3-5-16(26)6-4-15)29-17-7-9-18(10-8-17)36-19-11-12-20(22(28)33)21(27)13-19/h3-13H,2,14H2,1H3,(H2,28,33)(H,29,30,34) UNIJEBBEDPEKML-UHFFFAOYSA-N 266390 US9718790, I-2234 P2X purinoceptor 3 Homo sapiens 2.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266390 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266390&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945712 377005261 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505955 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(OCC3CC3)cc2)n(Cc2ccc(C)cc2)c1=O 266391 US9718790, I-0834 P2X purinoceptor 3 Homo sapiens 18.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266391 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266391&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118944973 377005262 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505956 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(C(C)=C)c(Cl)c2)n(Cc2ccc(C)cc2)c1=O 266392 US9718790, I-1491 P2X purinoceptor 3 Homo sapiens 284 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266392 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266392&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945441 377005263 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505957 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(F)c(c3)C(N)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H21ClFN5O4/c1-2-31-24(34)30-23(32(25(31)35)14-15-3-5-16(26)6-4-15)29-17-7-9-18(10-8-17)36-19-11-12-21(27)20(13-19)22(28)33/h3-13H,2,14H2,1H3,(H2,28,33)(H,29,30,34) QDMNZOBUNKHAGT-UHFFFAOYSA-N 266393 US9718790, I-2235 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266393 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266393&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021021 377005264 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505958 CC(C)COc1ccc(cc1C)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 266394 US9718790, I-0835 P2X purinoceptor 3 Homo sapiens 78.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266394 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266394&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118944998 377005265 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505959 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(C(C)=C)c(Cl)c2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 266395 US9718790, I-1492 P2X purinoceptor 3 Homo sapiens 461 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266395 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266395&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945549 377005266 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505960 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cncc(c3)C(N)=O)cc2)n(Cc2ccc(Cl)cn2)c1=O InChI=1S/C23H20ClN7O4/c1-2-30-22(33)29-21(31(23(30)34)13-17-4-3-15(24)11-27-17)28-16-5-7-18(8-6-16)35-19-9-14(20(25)32)10-26-12-19/h3-12H,2,13H2,1H3,(H2,25,32)(H,28,29,33) KTIKYVYMNWGPPV-UHFFFAOYSA-N 266396 US9718790, I-2236 P2X purinoceptor 3 Homo sapiens 62.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266396 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266396&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278395 377005267 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505961 CC(C)COc1ccc(cc1C)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(C)cc1 266397 US9718790, I-0836 P2X purinoceptor 3 Homo sapiens 95.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266397 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266397&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019639 377005268 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505962 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(C(C)C)c(Cl)c2)n(Cc2ccc(C)cc2)c1=O 266398 US9718790, I-1493 P2X purinoceptor 3 Homo sapiens 444 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266398 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266398&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945555 377005269 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505963 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccnc(c3)C(N)=O)cc2)n(Cc2ccc(Cl)cn2)c1=O InChI=1S/C23H20ClN7O4/c1-2-30-22(33)29-21(31(23(30)34)13-16-4-3-14(24)12-27-16)28-15-5-7-17(8-6-15)35-18-9-10-26-19(11-18)20(25)32/h3-12H,2,13H2,1H3,(H2,25,32)(H,28,29,33) QEVDTBSWBNKQOS-UHFFFAOYSA-N 266399 US9718790, I-2237 P2X purinoceptor 3 Homo sapiens 20.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266399 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266399&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278612 377005270 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505964 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(OCC3CC3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 266400 US9718790, I-0837 P2X purinoceptor 3 Homo sapiens 17.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266400 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266400&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019790 377005271 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505965 CC(C)c1ccc(cc1Cl)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(C)cc1 266401 US9718790, I-1494 P2X purinoceptor 3 Homo sapiens 571 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266401 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266401&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945447 377005272 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505966 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(n3)C(=O)OC)cc2)n(Cc2ccc(Cl)cn2)c1=O InChI=1S/C24H21ClN6O5/c1-3-30-23(33)29-22(31(24(30)34)14-17-8-7-15(25)13-26-17)27-16-9-11-18(12-10-16)36-20-6-4-5-19(28-20)21(32)35-2/h4-13H,3,14H2,1-2H3,(H,27,29,33) UXOBMNXOWULKSB-UHFFFAOYSA-N 266402 US9718790, I-2238 P2X purinoceptor 3 Homo sapiens 148 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266402 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266402&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945498 377005273 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505967 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(OCC3CC3)cc2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 266403 US9718790, I-0838 P2X purinoceptor 3 Homo sapiens 33.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266403 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266403&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019640 377005274 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505968 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(CC2(COC2)C(O)=O)c(=O)n1Cc1ccc(C)cc1 InChI=1S/C25H27ClN4O6/c1-15(2)36-20-9-8-18(10-19(20)26)27-22-28-23(33)30(12-25(21(31)32)13-35-14-25)24(34)29(22)11-17-6-4-16(3)5-7-17/h4-10,15H,11-14H2,1-3H3,(H,31,32)(H,27,28,33) CHJNOZVCGZQIFY-UHFFFAOYSA-N 266404 US9718790, I-1495 P2X purinoceptor 3 Homo sapiens 26.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266404 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266404&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945430 377005275 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505969 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(n3)C(O)=O)cc2)n(Cc2ccc(Cl)cn2)c1=O InChI=1S/C23H19ClN6O5/c1-2-29-22(33)28-21(30(23(29)34)13-16-7-6-14(24)12-25-16)26-15-8-10-17(11-9-15)35-19-5-3-4-18(27-19)20(31)32/h3-12H,2,13H2,1H3,(H,31,32)(H,26,28,33) POMATBLEWDYJOM-UHFFFAOYSA-N 266405 US9718790, I-2239 P2X purinoceptor 3 Homo sapiens 49.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266405 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266405&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945704 377005276 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505970 CCCOc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(C[C@H](C)C(=O)OC)c(=O)n1Cc1ccc(C)cc1 266406 US9718790, I-0839 P2X purinoceptor 3 Homo sapiens 12.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266406 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266406&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019641 377005277 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505971 CC(C)Cc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(CC2(COC2)C(O)=O)c(=O)n1Cc1ccc(C)cc1 InChI=1S/C26H29ClN4O5/c1-16(2)10-19-8-9-20(11-21(19)27)28-23-29-24(34)31(13-26(22(32)33)14-36-15-26)25(35)30(23)12-18-6-4-17(3)5-7-18/h4-9,11,16H,10,12-15H2,1-3H3,(H,32,33)(H,28,29,34) HPJWMVMIIIGBKV-UHFFFAOYSA-N 266407 US9718790, I-1496 P2X purinoceptor 3 Homo sapiens 9.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266407 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266407&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020472 377005278 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505972 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(n3)C(N)=O)cc2)n(Cc2ccc(Cl)cn2)c1=O InChI=1S/C23H20ClN7O4/c1-2-30-22(33)29-21(31(23(30)34)13-16-7-6-14(24)12-26-16)27-15-8-10-17(11-9-15)35-19-5-3-4-18(28-19)20(25)32/h3-12H,2,13H2,1H3,(H2,25,32)(H,27,29,33) DODFRGOCAYZFNF-UHFFFAOYSA-N 266408 US9718790, I-2240 P2X purinoceptor 3 Homo sapiens 21.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266408 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266408&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945673 377005279 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505973 CCCOc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(C)cc1 266409 US9718790, I-0840 P2X purinoceptor 3 Homo sapiens 17.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266409 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266409&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945035 377005280 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505974 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2cc(Cl)cc(Cl)c2)n(Cc2ccc(C)cc2)c1=O 266410 US9718790, I-1497 P2X purinoceptor 3 Homo sapiens 619 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266410 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266410&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020467 377005281 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505975 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(NC(C)=O)nc3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H23ClN6O4/c1-3-31-24(34)30-23(32(25(31)35)15-17-4-6-18(26)7-5-17)29-19-8-10-20(11-9-19)36-21-12-13-22(27-14-21)28-16(2)33/h4-14H,3,15H2,1-2H3,(H,27,28,33)(H,29,30,34) IMGZUMNOQYGZAY-UHFFFAOYSA-N 266411 US9718790, I-2241 P2X purinoceptor 3 Homo sapiens 1.000 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266411 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266411&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945419 377005282 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505976 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(C)c(c2)C(F)(F)F)n(Cc2ccc(Cl)cc2)c1=O 266412 US9718790, I-0841 P2X purinoceptor 3 Homo sapiens 150 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266412 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266412&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019729 377005283 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505977 CCOCc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(C[C@H](C)C(=O)OC)c(=O)n1Cc1ccc(C)cc1 266413 US9718790, I-1498 P2X purinoceptor 3 Homo sapiens 22.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266413 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266413&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020483 377005284 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505978 CCC(=O)Nc1ccc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(CC)c(=O)n2Cc2ccc(Cl)cc2)cn1 InChI=1S/C26H25ClN6O4/c1-3-23(34)30-22-14-13-21(15-28-22)37-20-11-9-19(10-12-20)29-24-31-25(35)32(4-2)26(36)33(24)16-17-5-7-18(27)8-6-17/h5-15H,3-4,16H2,1-2H3,(H,28,30,34)(H,29,31,35) GLJRIIUGLXFMAN-UHFFFAOYSA-N 266414 US9718790, I-2242 P2X purinoceptor 3 Homo sapiens <4.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266414 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266414&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945672 377005285 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505979 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(C)c(c2)C(F)(F)F)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 266415 US9718790, I-0843 P2X purinoceptor 3 Homo sapiens 183 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266415 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266415&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019762 377005286 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505980 CCOc1c(Cl)cc(cc1Cl)\N=c1/[nH]c(=O)n(C[C@H](C)C(=O)OC)c(=O)n1Cc1ccc(C)cc1 266416 US9718790, I-1499 P2X purinoceptor 3 Homo sapiens 19.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266416 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266416&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020521 377005287 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505981 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(NC(=O)NC4CC4)nc3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C27H26ClN7O4/c1-2-34-26(37)33-24(35(27(34)38)16-17-3-5-18(28)6-4-17)30-19-9-11-21(12-10-19)39-22-13-14-23(29-15-22)32-25(36)31-20-7-8-20/h3-6,9-15,20H,2,7-8,16H2,1H3,(H,30,33,37)(H2,29,31,32,36) RXQBLPASJPMRTN-UHFFFAOYSA-N 266417 US9718790, I-2243 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266417 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266417&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021012 377005288 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505982 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n(CC(C)(C)CC(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C25H28ClFN4O5/c1-15(2)36-20-10-9-18(11-19(20)27)28-22-29-23(34)31(14-25(3,4)12-21(32)33)24(35)30(22)13-16-5-7-17(26)8-6-16/h5-11,15H,12-14H2,1-4H3,(H,32,33)(H,28,29,34) JCVZHIPGAVXRDG-UHFFFAOYSA-N 266418 US9718790, I-0845 P2X purinoceptor 3 Homo sapiens 24.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266418 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266418&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278533 377005289 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505983 C[C@@H](Cn1c(=O)[nH]\c(=N/c2cc(Cl)cc(Cl)c2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 266419 US9718790, I-1500 P2X purinoceptor 3 Homo sapiens 897 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266419 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266419&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020485 377005290 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505984 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccnc(CN(C)C)c3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H27ClN6O3/c1-4-32-25(34)30-24(33(26(32)35)16-18-5-7-19(27)8-6-18)29-20-9-11-22(12-10-20)36-23-13-14-28-21(15-23)17-31(2)3/h5-15H,4,16-17H2,1-3H3,(H,29,30,34) ULBMCHRSFCYTBG-UHFFFAOYSA-N 266420 US9718790, I-2244 P2X purinoceptor 3 Homo sapiens 59.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266420 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266420&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945408 377005291 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505985 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(OCC(F)F)cc2)n(Cc2ccc(Cl)cc2)c1=O 266421 US9718790, I-0846 P2X purinoceptor 3 Homo sapiens 35.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266421 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266421&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945216 377005292 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505986 COCc1c(Cl)cc(cc1Cl)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(C)cc1 266422 US9718790, I-1501 P2X purinoceptor 3 Homo sapiens 11.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266422 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266422&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278349 377005293 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505987 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccnc(CNC)c3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H25ClN6O3/c1-3-31-24(33)30-23(32(25(31)34)16-17-4-6-18(26)7-5-17)29-19-8-10-21(11-9-19)35-22-12-13-28-20(14-22)15-27-2/h4-14,27H,3,15-16H2,1-2H3,(H,29,30,33) SCPKVDVKSAHPCM-UHFFFAOYSA-N 266423 US9718790, I-2245 P2X purinoceptor 3 Homo sapiens 108 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266423 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266423&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278651 377005294 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505988 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(OCC(F)F)cc2)n(Cc2ccc(C)cc2)c1=O 266424 US9718790, I-0847 P2X purinoceptor 3 Homo sapiens 31.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266424 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266424&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945240 377005295 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505989 CCOCc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(C)cc1 266425 US9718790, I-1502 P2X purinoceptor 3 Homo sapiens 107 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266425 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266425&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278350 377005296 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505990 CCn1c(=O)[nH]\c(=N/[C@H]2CC[C@@H](CC2)Oc2ccnc(c2)C(=O)NC)n(Cc2ccc(Cl)cc2)c1=O 266426 US9718790, I-2246 P2X purinoceptor 3 Homo sapiens 790 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266426 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266426&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945525 377005297 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505991 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(OCC(F)F)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 266427 US9718790, I-0848 P2X purinoceptor 3 Homo sapiens 60.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266427 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266427&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945044 377005298 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505992 CCOC(=O)CCn1c(=O)[nH]\c(=N/c2ccc3oc(CC)c(C)c3c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H27ClN4O5/c1-4-21-16(3)20-14-19(10-11-22(20)36-21)28-24-29-25(33)30(13-12-23(32)35-5-2)26(34)31(24)15-17-6-8-18(27)9-7-17/h6-11,14H,4-5,12-13,15H2,1-3H3,(H,28,29,33) LWBVFCROECNWPQ-UHFFFAOYSA-N 266428 US9718790, I-1503 P2X purinoceptor 3 Homo sapiens 12.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266428 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266428&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945200 377005299 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505993 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cc(sn3)C(=O)OC)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H20ClN5O5S/c1-3-28-22(31)26-21(29(23(28)32)13-14-4-6-15(24)7-5-14)25-16-8-10-17(11-9-16)34-19-12-18(35-27-19)20(30)33-2/h4-12H,3,13H2,1-2H3,(H,25,26,31) YYMZPFBYKSQNNN-UHFFFAOYSA-N 266429 US9718790, I-2247 P2X purinoceptor 3 Homo sapiens 3.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266429 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266429&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020153 377005300 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504272 CC(C)n1c(=O)nc(Nc2cccc(c2)C(F)(F)F)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C20H18ClF3N4O2/c1-12(2)28-18(29)26-17(25-16-5-3-4-14(10-16)20(22,23)24)27(19(28)30)11-13-6-8-15(21)9-7-13/h3-10,12H,11H2,1-2H3,(H,25,26,29) UUGKLNMQRWYVRO-UHFFFAOYSA-N 183070 US9150546, I-020::US9688643, I-020::US9718790, I-0020 P2X purinoceptor 3 Homo sapiens 384 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183070 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183070&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821112 313634470 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504273 CC(C)Oc1ccc(cc1C)\N=C1/NCN(C[C@H](C)C(O)=O)C(=O)N1Cc1ccc(C=C)cc1 InChI=1S/C26H32N4O4/c1-6-20-7-9-21(10-8-20)15-30-25(27-16-29(26(30)33)14-19(5)24(31)32)28-22-11-12-23(18(4)13-22)34-17(2)3/h6-13,17,19H,1,14-16H2,2-5H3,(H,27,28)(H,31,32)/t19-/m0/s1 VYIFJUFHMQLRTL-IBGZPJMESA-N 264721 US9718790, I-0897 P2X purinoceptor 3 Homo sapiens 25.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264721 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264721&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278275 377003599 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504274 CCc1oc2ccc(cc2c1C)\N=c1/[nH]c(=O)n(CC2(CC2)C(O)=O)c(=O)n1Cc1ccc(C)cc1 InChI=1S/C27H28N4O5/c1-4-21-17(3)20-13-19(9-10-22(20)36-21)28-24-29-25(34)31(15-27(11-12-27)23(32)33)26(35)30(24)14-18-7-5-16(2)6-8-18/h5-10,13H,4,11-12,14-15H2,1-3H3,(H,32,33)(H,28,29,34) RRPMEAKMLKCNPZ-UHFFFAOYSA-N 264722 US9718790, I-1555 P2X purinoceptor 3 Homo sapiens 16.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264722 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264722&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945557 377003600 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504275 CC(C)n1c(=O)nc(Nc2cccc(c2)C(F)(F)F)n(Cc2ccc(C)cc2)c1=O InChI=1S/C21H21F3N4O2/c1-13(2)28-19(29)26-18(25-17-6-4-5-16(11-17)21(22,23)24)27(20(28)30)12-15-9-7-14(3)8-10-15/h4-11,13H,12H2,1-3H3,(H,25,26,29) YOKVDDNYLFEVNF-UHFFFAOYSA-N 183071 US9150546, I-021::US9688643, I-021::US9718790, I-0021 P2X purinoceptor 3 Homo sapiens 197 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183071 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183071&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 75237521 313634471 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504276 CCc1ccc(CN2C(=O)N(C[C@H](C)C(O)=O)CN\C2=N/c2ccc(OC(C)C)c(C)c2)cc1 InChI=1S/C26H34N4O4/c1-6-20-7-9-21(10-8-20)15-30-25(27-16-29(26(30)33)14-19(5)24(31)32)28-22-11-12-23(18(4)13-22)34-17(2)3/h7-13,17,19H,6,14-16H2,1-5H3,(H,27,28)(H,31,32)/t19-/m0/s1 NBXGTYSXBXFEGU-IBGZPJMESA-N 264724 US9718790, I-0898 P2X purinoceptor 3 Homo sapiens 20.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264724 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264724&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278534 377003602 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504277 CCc1nc2ccc(cc2s1)\N=c1/[nH]c(=O)n(CC2(CC2)C(O)=O)c(=O)n1Cc1ccc(C)cc1 InChI=1S/C25H25N5O4S/c1-3-20-27-18-9-8-17(12-19(18)35-20)26-22-28-23(33)30(14-25(10-11-25)21(31)32)24(34)29(22)13-16-6-4-15(2)5-7-16/h4-9,12H,3,10-11,13-14H2,1-2H3,(H,31,32)(H,26,28,33) DDKLGUJTZXJQEG-UHFFFAOYSA-N 264725 US9718790, I-1556 P2X purinoceptor 3 Homo sapiens 11.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264725 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264725&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020489 377003603 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504278 CCCCn1c(=O)nc(Nc2cccc(c2)C(F)(F)F)n(Cc2ccc(C)cc2)c1=O InChI=1S/C22H23F3N4O2/c1-3-4-12-28-20(30)27-19(26-18-7-5-6-17(13-18)22(23,24)25)29(21(28)31)14-16-10-8-15(2)9-11-16/h5-11,13H,3-4,12,14H2,1-2H3,(H,26,27,30) CSTQVHSGLNKRJV-UHFFFAOYSA-N 183072 US9150546, I-029::US9688643, I-029::US9718790, I-0029 P2X purinoceptor 3 Homo sapiens 595 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183072 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183072&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 75237553 313634472 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504279 CCCOc1ccc(cc1)\N=C1/NCN([C@@H](C)[C@@H](C)C(=O)OC)C(=O)N1Cc1ccc(Cl)cc1 InChI=1S/C25H31ClN4O4/c1-5-14-34-22-12-10-21(11-13-22)28-24-27-16-30(18(3)17(2)23(31)33-4)25(32)29(24)15-19-6-8-20(26)9-7-19/h6-13,17-18H,5,14-16H2,1-4H3,(H,27,28)/t17-,18+/m1/s1 FHMSQDUTUCHVME-MSOLQXFVSA-N 264727 US9718790, I-0899 P2X purinoceptor 3 Homo sapiens 23.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264727 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264727&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278289 377003605 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504280 CCCc1nc2ccc(cc2s1)\N=c1/[nH]c(=O)n(CCC(=O)OCC)c(=O)n1Cc1ccc(C)cc1 InChI=1S/C26H29N5O4S/c1-4-6-22-28-20-12-11-19(15-21(20)36-22)27-24-29-25(33)30(14-13-23(32)35-5-2)26(34)31(24)16-18-9-7-17(3)8-10-18/h7-12,15H,4-6,13-14,16H2,1-3H3,(H,27,29,33) IEIPIPACBYISCO-UHFFFAOYSA-N 264728 US9718790, I-1558 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264728 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264728&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020431 377003606 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504281 Cc1ccc(Cn2c(Nc3cccc(c3)C(F)(F)F)nc(=O)n(c2=O)C(C)(C)C)cc1 InChI=1S/C22H23F3N4O2/c1-14-8-10-15(11-9-14)13-28-18(27-19(30)29(20(28)31)21(2,3)4)26-17-7-5-6-16(12-17)22(23,24)25/h5-12H,13H2,1-4H3,(H,26,27,30) GSQTVLOBZSWCFK-UHFFFAOYSA-N 183073 US9150546, I-097::US9688643, I-097::US9718790, I-0097 P2X purinoceptor 3 Homo sapiens 505 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183073 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183073&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821135 313634473 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504282 COC(=O)[C@H](C)[C@H](C)N1CN\C(=N/c2ccc(OCC3CC3)cc2)N(Cc2ccc(Cl)cc2)C1=O InChI=1S/C26H31ClN4O4/c1-17(24(32)34-3)18(2)31-16-28-25(30(26(31)33)14-19-6-8-21(27)9-7-19)29-22-10-12-23(13-11-22)35-15-20-4-5-20/h6-13,17-18,20H,4-5,14-16H2,1-3H3,(H,28,29)/t17-,18+/m1/s1 VHDFBPLTRCJFQW-MSOLQXFVSA-N 264732 US9718790, I-0900 P2X purinoceptor 3 Homo sapiens 18.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264732 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264732&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278211 377003610 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504283 CCOC(=O)CCn1c(=O)[nH]\c(=N/c2ccc3nc(sc3c2)C2CC2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C26H27N5O4S/c1-3-35-22(32)12-13-30-25(33)29-24(31(26(30)34)15-17-6-4-16(2)5-7-17)27-19-10-11-20-21(14-19)36-23(28-20)18-8-9-18/h4-7,10-11,14,18H,3,8-9,12-13,15H2,1-2H3,(H,27,29,33) MEWQUBPCDMUOEJ-UHFFFAOYSA-N 264733 US9718790, I-1559 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264733 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264733&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020432 377003611 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504284 CC(C)n1c(=O)nc(Nc2ccc(Oc3ccccc3)cc2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C26H26N4O3/c1-18(2)30-25(31)28-24(29(26(30)32)17-20-11-9-19(3)10-12-20)27-21-13-15-23(16-14-21)33-22-7-5-4-6-8-22/h4-16,18H,17H2,1-3H3,(H,27,28,31) WTXITHIOEDHEDI-UHFFFAOYSA-N 183074 US9150546, I-116::US9688643, I-116::US9718790, I-0116 P2X purinoceptor 3 Homo sapiens 484 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183074 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183074&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821393 313634474 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504285 COC(=O)[C@@H](C)CN1CN\C(=N/c2ccc(OC(C)C)c(Br)c2)N(Cc2ccc(C)cc2)C1=O InChI=1S/C25H31BrN4O4/c1-16(2)34-22-11-10-20(12-21(22)26)28-24-27-15-29(13-18(4)23(31)33-5)25(32)30(24)14-19-8-6-17(3)7-9-19/h6-12,16,18H,13-15H2,1-5H3,(H,27,28)/t18-/m0/s1 KBQZCVRWPYJFFU-SFHVURJKSA-N 264735 US9718790, I-0901 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264735 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264735&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278473 377003613 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504286 CCCc1nc2ccc(cc2s1)\N=c1/[nH]c(=O)n(CCC(O)=O)c(=O)n1Cc1ccc(C)cc1 InChI=1S/C24H25N5O4S/c1-3-4-20-26-18-10-9-17(13-19(18)34-20)25-22-27-23(32)28(12-11-21(30)31)24(33)29(22)14-16-7-5-15(2)6-8-16/h5-10,13H,3-4,11-12,14H2,1-2H3,(H,30,31)(H,25,27,32) DHKPKCFNGCPYGY-UHFFFAOYSA-N 264736 US9718790, I-1560 P2X purinoceptor 3 Homo sapiens 51.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264736 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264736&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020434 377003614 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504287 CC(C)n1c(=O)nc(Nc2cccc(Cl)c2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C20H21ClN4O2/c1-13(2)25-19(26)23-18(22-17-6-4-5-16(21)11-17)24(20(25)27)12-15-9-7-14(3)8-10-15/h4-11,13H,12H2,1-3H3,(H,22,23,26) JDTYNPPCONPDCJ-UHFFFAOYSA-N 183075 US9150546, I-117::US9688643, I-117::US9718790, I-0117 P2X purinoceptor 3 Homo sapiens 387 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183075 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183075&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76820975 313634475 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504288 CCOC(=O)C1(CN2CN\C(=N/c3ccc(OC(C)C)c(Cl)c3)N(Cc3ccc(C)cc3)C2=O)CC1 InChI=1S/C27H33ClN4O4/c1-5-35-24(33)27(12-13-27)16-31-17-29-25(30-21-10-11-23(22(28)14-21)36-18(2)3)32(26(31)34)15-20-8-6-19(4)7-9-20/h6-11,14,18H,5,12-13,15-17H2,1-4H3,(H,29,30) YFYHHMZWRCJBMK-UHFFFAOYSA-N 264738 US9718790, I-0902 P2X purinoceptor 3 Homo sapiens 10.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264738 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264738&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278535 377003616 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504289 Cc1ccc(Cn2c(=O)n(CCC(O)=O)c(=O)[nH]\c2=N/c2ccc3nc(sc3c2)C2CC2)cc1 InChI=1S/C24H23N5O4S/c1-14-2-4-15(5-3-14)13-29-22(27-23(32)28(24(29)33)11-10-20(30)31)25-17-8-9-18-19(12-17)34-21(26-18)16-6-7-16/h2-5,8-9,12,16H,6-7,10-11,13H2,1H3,(H,30,31)(H,25,27,32) HIDPGCWRGHJOMA-UHFFFAOYSA-N 264739 US9718790, I-1561 P2X purinoceptor 3 Homo sapiens 32.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264739 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264739&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021172 377003617 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504290 CSc1cccc(Nc2nc(=O)n(C(C)C)c(=O)n2Cc2ccc(C)cc2)c1 InChI=1S/C21H24N4O2S/c1-14(2)25-20(26)23-19(22-17-6-5-7-18(12-17)28-4)24(21(25)27)13-16-10-8-15(3)9-11-16/h5-12,14H,13H2,1-4H3,(H,22,23,26) SERAWUWTGODSSL-UHFFFAOYSA-N 183076 US9150546, I-118::US9688643, I-118::US9718790, I-0118 P2X purinoceptor 3 Homo sapiens 231 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183076 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183076&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 75237596 313634476 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504291 CCOC(=O)C1(CN2CN\C(=N/c3ccc(OCC)c(Cl)c3)N(Cc3ccc(C)cc3)C2=O)CC1 InChI=1S/C26H31ClN4O4/c1-4-34-22-11-10-20(14-21(22)27)29-24-28-17-30(16-26(12-13-26)23(32)35-5-2)25(33)31(24)15-19-8-6-18(3)7-9-19/h6-11,14H,4-5,12-13,15-17H2,1-3H3,(H,28,29) KQWDBYKJXWEOOJ-UHFFFAOYSA-N 264741 US9718790, I-0903 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264741 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264741&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278212 377003619 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504292 CCOC(=O)CCn1c(=O)[nH]\c(=N/c2ccc3nc(sc3c2)C(C)C)n(Cc2ccc(C)cc2)c1=O InChI=1S/C26H29N5O4S/c1-5-35-22(32)12-13-30-25(33)29-24(31(26(30)34)15-18-8-6-17(4)7-9-18)27-19-10-11-20-21(14-19)36-23(28-20)16(2)3/h6-11,14,16H,5,12-13,15H2,1-4H3,(H,27,29,33) VNTAGNHSIARFKW-UHFFFAOYSA-N 264742 US9718790, I-1562 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264742 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264742&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021120 377003620 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504293 CC(C)Oc1ccc(Nc2nc(=O)n(C(C)C)c(=O)n2Cc2ccc(C)cc2)cc1 InChI=1S/C23H28N4O3/c1-15(2)27-22(28)25-21(24-19-10-12-20(13-11-19)30-16(3)4)26(23(27)29)14-18-8-6-17(5)7-9-18/h6-13,15-16H,14H2,1-5H3,(H,24,25,28) SFHXKQUAZHFZDZ-UHFFFAOYSA-N 183077 US9150546, I-121::US9688643, I-121::US9718790, I-0121 P2X purinoceptor 3 Homo sapiens 246 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183077 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183077&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821026 313634477 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504294 CC(C)Oc1ccc(cc1Cl)\N=C1/NCN(CC2(CC2)C(O)=O)C(=O)N1Cc1ccc(C)cc1 InChI=1S/C25H29ClN4O4/c1-16(2)34-21-9-8-19(12-20(21)26)28-23-27-15-29(14-25(10-11-25)22(31)32)24(33)30(23)13-18-6-4-17(3)5-7-18/h4-9,12,16H,10-11,13-15H2,1-3H3,(H,27,28)(H,31,32) GURIBNCXJJNYMM-UHFFFAOYSA-N 264744 US9718790, I-0904 P2X purinoceptor 3 Homo sapiens 11.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264744 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264744&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278290 377003622 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504295 CC(C)c1nc2ccc(cc2s1)\N=c1/[nH]c(=O)n(CCC(O)=O)c(=O)n1Cc1ccc(C)cc1 InChI=1S/C24H25N5O4S/c1-14(2)21-26-18-9-8-17(12-19(18)34-21)25-22-27-23(32)28(11-10-20(30)31)24(33)29(22)13-16-6-4-15(3)5-7-16/h4-9,12,14H,10-11,13H2,1-3H3,(H,30,31)(H,25,27,32) IOODFXUAMJUYBH-UHFFFAOYSA-N 264745 US9718790, I-1563 P2X purinoceptor 3 Homo sapiens 31.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264745 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264745&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021069 377003623 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504296 CC(C)n1c(=O)nc(Nc2ccc3[nH]ccc3c2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C22H23N5O2/c1-14(2)27-21(28)25-20(24-18-8-9-19-17(12-18)10-11-23-19)26(22(27)29)13-16-6-4-15(3)5-7-16/h4-12,14,23H,13H2,1-3H3,(H,24,25,28) VFEADJKRJBHYRS-UHFFFAOYSA-N 183078 US9150546, I-123::US9688643, I-123::US9718790, I-0123 P2X purinoceptor 3 Homo sapiens 815 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183078 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183078&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 75237597 313634478 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504297 CCOc1ccc(cc1Cl)\N=C1/NCN(CC2(CC2)C(O)=O)C(=O)N1Cc1ccc(C)cc1 InChI=1S/C24H27ClN4O4/c1-3-33-20-9-8-18(12-19(20)25)27-22-26-15-28(14-24(10-11-24)21(30)31)23(32)29(22)13-17-6-4-16(2)5-7-17/h4-9,12H,3,10-11,13-15H2,1-2H3,(H,26,27)(H,30,31) UJGZPWYIXZQPLG-UHFFFAOYSA-N 264747 US9718790, I-0905 P2X purinoceptor 3 Homo sapiens 22.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264747 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264747&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278213 377003625 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504298 CCc1oc2ccc(cc2c1C)\N=c1/[nH]c(=O)n(CC(=O)OC)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C24H23ClN4O5/c1-4-19-14(2)18-11-17(9-10-20(18)34-19)26-22-27-23(31)29(13-21(30)33-3)24(32)28(22)12-15-5-7-16(25)8-6-15/h5-11H,4,12-13H2,1-3H3,(H,26,27,31) BOGMDKWREOOYPV-UHFFFAOYSA-N 264748 US9718790, I-1564 P2X purinoceptor 3 Homo sapiens 13.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264748 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264748&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021065 377003626 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504299 CC(C)n1c(=O)nc(Nc2cccc(c2)C(F)(F)F)n(Cc2ccc(F)cc2)c1=O InChI=1S/C20H18F4N4O2/c1-12(2)28-18(29)26-17(25-16-5-3-4-14(10-16)20(22,23)24)27(19(28)30)11-13-6-8-15(21)9-7-13/h3-10,12H,11H2,1-2H3,(H,25,26,29) MSMVJAKQZYUCKV-UHFFFAOYSA-N 183079 US9150546, I-126::US9688643, I-126::US9718790, I-0126 P2X purinoceptor 3 Homo sapiens 689 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183079 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183079&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821386 313634479 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504300 CC(C)Oc1ccc(cc1C)\N=c1/[nH]c(=O)n(CC2(CO)COC2)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C25H29ClN4O5/c1-16(2)35-21-9-8-20(10-17(21)3)27-22-28-23(32)30(12-25(13-31)14-34-15-25)24(33)29(22)11-18-4-6-19(26)7-5-18/h4-10,16,31H,11-15H2,1-3H3,(H,27,28,32) WSNGGPSNGJYGJN-UHFFFAOYSA-N 264750 US9718790, I-0906 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264750 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264750&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945222 377003628 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504301 CCc1oc2ccc(cc2c1C)\N=c1/[nH]c(=O)n(CCNC(=O)C(F)(F)F)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C25H23ClF3N5O4/c1-3-19-14(2)18-12-17(8-9-20(18)38-19)31-22-32-23(36)33(11-10-30-21(35)25(27,28)29)24(37)34(22)13-15-4-6-16(26)7-5-15/h4-9,12H,3,10-11,13H2,1-2H3,(H,30,35)(H,31,32,36) MKDFXRSDFZYBIT-UHFFFAOYSA-N 264751 US9718790, I-1565 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264751 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264751&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130279139 377003629 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504302 CC(C)n1c(=O)nc(Nc2ccc(Oc3ccccc3)cc2)n(Cc2ccc(F)cc2)c1=O InChI=1S/C25H23FN4O3/c1-17(2)30-24(31)28-23(29(25(30)32)16-18-8-10-19(26)11-9-18)27-20-12-14-22(15-13-20)33-21-6-4-3-5-7-21/h3-15,17H,16H2,1-2H3,(H,27,28,31) CNSNAAGHAOMOPM-UHFFFAOYSA-N 183080 US9150546, I-128::US9688643, I-128::US9718790, I-0128 P2X purinoceptor 3 Homo sapiens 840 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183080 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183080&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821421 313634480 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504303 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(C=C)c2)n(Cc2ccc(C)cc2)c1=O 264753 US9718790, I-0907 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264753 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264753&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019634 377003631 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504304 CCc1oc2ccc(cc2c1C)\N=c1/[nH]c(=O)n(CCNC(C)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C25H26ClN5O4/c1-4-21-15(2)20-13-19(9-10-22(20)35-21)28-23-29-24(33)30(12-11-27-16(3)32)25(34)31(23)14-17-5-7-18(26)8-6-17/h5-10,13H,4,11-12,14H2,1-3H3,(H,27,32)(H,28,29,33) AULZAURNDUZLBF-UHFFFAOYSA-N 264754 US9718790, I-1566 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264754 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264754&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019951 377003632 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504305 CSc1cccc(Nc2nc(=O)n(C(C)C)c(=O)n2Cc2ccc(F)cc2)c1 InChI=1S/C20H21FN4O2S/c1-13(2)25-19(26)23-18(22-16-5-4-6-17(11-16)28-3)24(20(25)27)12-14-7-9-15(21)10-8-14/h4-11,13H,12H2,1-3H3,(H,22,23,26) KUHNCTZRZIHMNZ-UHFFFAOYSA-N 183081 US9150546, I-130::US9688643, I-130::US9718790, I-0130 P2X purinoceptor 3 Homo sapiens 953 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183081 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183081&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821143 313634481 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504306 CCc1cc(ccc1OC(C)C)\N=c1/[nH]c(=O)n(C[C@H](C)C(=O)OC)c(=O)n1Cc1ccc(C)cc1 264756 US9718790, I-0908 P2X purinoceptor 3 Homo sapiens 13.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264756 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264756&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 86689119 377003634 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504307 CCc1oc2ccc(cc2c1C)\N=c1/[nH]c(=O)n(CCCNC(=O)C(F)(F)F)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C26H25ClF3N5O4/c1-3-20-15(2)19-13-18(9-10-21(19)39-20)32-23-33-24(37)34(12-4-11-31-22(36)26(28,29)30)25(38)35(23)14-16-5-7-17(27)8-6-16/h5-10,13H,3-4,11-12,14H2,1-2H3,(H,31,36)(H,32,33,37) KPAINECLCQMKRD-UHFFFAOYSA-N 264757 US9718790, I-1567 P2X purinoceptor 3 Homo sapiens 12.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264757 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264757&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278589 377003635 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504308 CC(C)Oc1ccc(Nc2nc(=O)n(C(C)C)c(=O)n2Cc2ccc(F)cc2)cc1 InChI=1S/C22H25FN4O3/c1-14(2)27-21(28)25-20(24-18-9-11-19(12-10-18)30-15(3)4)26(22(27)29)13-16-5-7-17(23)8-6-16/h5-12,14-15H,13H2,1-4H3,(H,24,25,28) CFGDBJCENZPXFT-UHFFFAOYSA-N 183082 US9150546, I-133::US9688643, I-133::US9718790, I-0133 P2X purinoceptor 3 Homo sapiens 339 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183082 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183082&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821219 313634482 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504309 CC(C)Oc1ccc(cc1Br)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(C)cc1 264759 US9718790, I-0909 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264759 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264759&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020077 377003637 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504310 CCc1oc2ccc(cc2c1C)\N=c1/[nH]c(=O)n(CCCNC(C)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C26H28ClN5O4/c1-4-22-16(2)21-14-20(10-11-23(21)36-22)29-24-30-25(34)31(13-5-12-28-17(3)33)26(35)32(24)15-18-6-8-19(27)9-7-18/h6-11,14H,4-5,12-13,15H2,1-3H3,(H,28,33)(H,29,30,34) SNXSWIMIGKIBLJ-UHFFFAOYSA-N 264760 US9718790, I-1568 P2X purinoceptor 3 Homo sapiens 10.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264760 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264760&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020009 377003638 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504311 CCn1c(=O)nc(Nc2cccc(c2)C(F)(F)F)n(Cc2ccc(F)cc2)c1=O InChI=1S/C19H16F4N4O2/c1-2-26-17(28)25-16(24-15-5-3-4-13(10-15)19(21,22)23)27(18(26)29)11-12-6-8-14(20)9-7-12/h3-10H,2,11H2,1H3,(H,24,25,28) VQUSPBTZXROEJD-UHFFFAOYSA-N 183083 US9150546, I-138::US9688643, I-138::US9718790, I-0138 P2X purinoceptor 3 Homo sapiens 619 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183083 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183083&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821341 313634483 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504312 CC(C)Oc1ccc(cc1C=C)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(C)cc1 264762 US9718790, I-0910 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264762 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264762&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020430 377003640 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504313 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc3nc(C)sc3c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H24ClN5O4S/c1-14-26-18-10-9-17(11-19(18)35-14)27-21-28-22(32)30(13-24(2,3)20(31)34-4)23(33)29(21)12-15-5-7-16(25)8-6-15/h5-11H,12-13H2,1-4H3,(H,27,28,32) OBYALDSPPSRMAK-UHFFFAOYSA-N 264763 US9718790, I-1569 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264763 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264763&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278590 377003641 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504314 CCn1c(=O)nc(Nc2ccc(Oc3ccccc3)cc2)n(Cc2ccc(F)cc2)c1=O InChI=1S/C24H21FN4O3/c1-2-28-23(30)27-22(29(24(28)31)16-17-8-10-18(25)11-9-17)26-19-12-14-21(15-13-19)32-20-6-4-3-5-7-20/h3-15H,2,16H2,1H3,(H,26,27,30) XYDHNFAHHWQXIT-UHFFFAOYSA-N 183084 US9150546, I-141::US9688643, I-141::US9718790, I-0141 P2X purinoceptor 3 Homo sapiens 685 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183084 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183084&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76820951 313634484 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504315 CCc1cc(ccc1OC(C)C)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(C)cc1 264765 US9718790, I-0911 P2X purinoceptor 3 Homo sapiens 15.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264765 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264765&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020087 377003643 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504316 CNC(=O)CCn1c(=O)[nH]\c(=N/c2ccc3nc(C)sc3c2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C23H24N6O3S/c1-14-4-6-16(7-5-14)13-29-21(26-17-8-9-18-19(12-17)33-15(2)25-18)27-22(31)28(23(29)32)11-10-20(30)24-3/h4-9,12H,10-11,13H2,1-3H3,(H,24,30)(H,26,27,31) GKVBGHICVSTLGK-UHFFFAOYSA-N 264766 US9718790, I-1570 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264766 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264766&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019957 377003644 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504317 CC(C)n1c(=O)nc(Nc2cccc(c2)C(F)(F)F)n(Cc2ccc(Cl)cn2)c1=O InChI=1S/C19H17ClF3N5O2/c1-11(2)28-17(29)26-16(25-14-5-3-4-12(8-14)19(21,22)23)27(18(28)30)10-15-7-6-13(20)9-24-15/h3-9,11H,10H2,1-2H3,(H,25,26,29) YBSHZIGUKUOWCU-UHFFFAOYSA-N 183085 US9150546, I-162::US9688643, I-162::US9718790, I-0162 P2X purinoceptor 3 Homo sapiens 379 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183085 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183085&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821366 313634485 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504318 CCCOc1ccc(cc1)\N=c1/[nH]c(=O)n(CC2(CC2)C(=O)OCC)c(=O)n1Cc1ccc(C)cc1 InChI=1S/C27H32N4O5/c1-4-16-36-22-12-10-21(11-13-22)28-24-29-25(33)31(18-27(14-15-27)23(32)35-5-2)26(34)30(24)17-20-8-6-19(3)7-9-20/h6-13H,4-5,14-18H2,1-3H3,(H,28,29,33) STVPXVKTGNUATF-UHFFFAOYSA-N 264768 US9718790, I-0912 P2X purinoceptor 3 Homo sapiens 10.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264768 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264768&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020088 377003646 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504319 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc3nc(C)sc3c2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C25H27N5O4S/c1-15-6-8-17(9-7-15)13-29-22(27-18-10-11-19-20(12-18)35-16(2)26-19)28-23(32)30(24(29)33)14-25(3,4)21(31)34-5/h6-12H,13-14H2,1-5H3,(H,27,28,32) DNQWJDQTWSCPTB-UHFFFAOYSA-N 264769 US9718790, I-1571 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264769 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264769&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945205 377003647 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504320 CC(C)n1c(=O)nc(Nc2ccc(Oc3ccccc3)cc2)n(Cc2ccc(Cl)cn2)c1=O InChI=1S/C24H22ClN5O3/c1-16(2)30-23(31)28-22(29(24(30)32)15-19-9-8-17(25)14-26-19)27-18-10-12-21(13-11-18)33-20-6-4-3-5-7-20/h3-14,16H,15H2,1-2H3,(H,27,28,31) BJIFHYQSYDRPLS-UHFFFAOYSA-N 183086 US9150546, I-164::US9688643, I-164::US9718790, I-0164 P2X purinoceptor 3 Homo sapiens 860 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183086 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183086&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821170 313634486 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504321 CCOC(=O)C1(Cn2c(=O)[nH]\c(=N/c3ccc(OCC4CC4)cc3)n(Cc3ccc(C)cc3)c2=O)CC1 InChI=1S/C28H32N4O5/c1-3-36-24(33)28(14-15-28)18-32-26(34)30-25(31(27(32)35)16-20-6-4-19(2)5-7-20)29-22-10-12-23(13-11-22)37-17-21-8-9-21/h4-7,10-13,21H,3,8-9,14-18H2,1-2H3,(H,29,30,34) ZDOCCHXRYOAMKV-UHFFFAOYSA-N 264771 US9718790, I-0913 P2X purinoceptor 3 Homo sapiens 9.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264771 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264771&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020224 377003649 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504322 CCc1nc2ccc(cc2s1)\N=c1/[nH]c(=O)n(CC(C)(C)C(=O)OC)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C25H26ClN5O4S/c1-5-20-28-18-11-10-17(12-19(18)36-20)27-22-29-23(33)31(14-25(2,3)21(32)35-4)24(34)30(22)13-15-6-8-16(26)9-7-15/h6-12H,5,13-14H2,1-4H3,(H,27,29,33) VMFRNMRKXJBHAN-UHFFFAOYSA-N 264772 US9718790, I-1572 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264772 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264772&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945224 377003650 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504323 CC(C)n1c(=O)nc(Nc2cccc(OC(F)(F)F)c2)n(Cc2ccc(F)cc2)c1=O InChI=1S/C20H18F4N4O3/c1-12(2)28-18(29)26-17(25-15-4-3-5-16(10-15)31-20(22,23)24)27(19(28)30)11-13-6-8-14(21)9-7-13/h3-10,12H,11H2,1-2H3,(H,25,26,29) CFHUZVXARLKACN-UHFFFAOYSA-N 183087 US9150546, I-181::US9688643, I-181::US9718790, I-0181 P2X purinoceptor 3 Homo sapiens 985 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183087 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183087&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821033 313634487 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504324 CCCOc1ccc(cc1)\N=c1/[nH]c(=O)n(CC2(CC2)C(O)=O)c(=O)n1Cc1ccc(C)cc1 InChI=1S/C25H28N4O5/c1-3-14-34-20-10-8-19(9-11-20)26-22-27-23(32)29(16-25(12-13-25)21(30)31)24(33)28(22)15-18-6-4-17(2)5-7-18/h4-11H,3,12-16H2,1-2H3,(H,30,31)(H,26,27,32) XWPQUAUILOMTKS-UHFFFAOYSA-N 264774 US9718790, I-0914 P2X purinoceptor 3 Homo sapiens 74.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264774 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264774&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020132 377003652 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504325 CCc1nc2ccc(cc2s1)\N=c1/[nH]c(=O)n(CC(C)(C)C(=O)OC)c(=O)n1Cc1ccc(C)cc1 InChI=1S/C26H29N5O4S/c1-6-21-28-19-12-11-18(13-20(19)36-21)27-23-29-24(33)31(15-26(3,4)22(32)35-5)25(34)30(23)14-17-9-7-16(2)8-10-17/h7-13H,6,14-15H2,1-5H3,(H,27,29,33) VMSITVNPTPYAGE-UHFFFAOYSA-N 264775 US9718790, I-1573 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264775 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264775&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117756449 377003653 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504326 CC(C)n1c(=O)nc(Nc2cccc(F)c2)n(Cc2ccc(F)cc2)c1=O InChI=1S/C19H18F2N4O2/c1-12(2)25-18(26)23-17(22-16-5-3-4-15(21)10-16)24(19(25)27)11-13-6-8-14(20)9-7-13/h3-10,12H,11H2,1-2H3,(H,22,23,26) PLOUZYMGEYTAOO-UHFFFAOYSA-N 183088 US9150546, I-182::US9688643, I-182::US9718790, I-0182 P2X purinoceptor 3 Homo sapiens 714 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183088 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183088&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821334 313634488 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504327 Cc1ccc(Cn2c(=O)n(CC3(CC3)C(O)=O)c(=O)[nH]\c2=N/c2ccc(OCC3CC3)cc2)cc1 InChI=1S/C26H28N4O5/c1-17-2-4-18(5-3-17)14-29-23(27-20-8-10-21(11-9-20)35-15-19-6-7-19)28-24(33)30(25(29)34)16-26(12-13-26)22(31)32/h2-5,8-11,19H,6-7,12-16H2,1H3,(H,31,32)(H,27,28,33) LGAWWICUZNFELB-UHFFFAOYSA-N 264777 US9718790, I-0915 P2X purinoceptor 3 Homo sapiens 75.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264777 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264777&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020167 377003655 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504328 CCc1oc2ccc(cc2c1C)\N=c1/[nH]c(=O)n(CC(C)(C)C(=O)OC)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C27H29ClN4O5/c1-6-21-16(2)20-13-19(11-12-22(20)37-21)29-24-30-25(34)32(15-27(3,4)23(33)36-5)26(35)31(24)14-17-7-9-18(28)10-8-17/h7-13H,6,14-15H2,1-5H3,(H,29,30,34) RSRSEUWKGNQFHY-UHFFFAOYSA-N 264778 US9718790, I-1574 P2X purinoceptor 3 Homo sapiens 18.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264778 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264778&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945349 377003656 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504329 CC(C)Oc1ccc(Nc2nc(=O)n(C(C)C)c(=O)n2Cc2ccc(Cl)cc2)cc1 InChI=1S/C22H25ClN4O3/c1-14(2)27-21(28)25-20(24-18-9-11-19(12-10-18)30-15(3)4)26(22(27)29)13-16-5-7-17(23)8-6-16/h5-12,14-15H,13H2,1-4H3,(H,24,25,28) KRYNINNUFDZTED-UHFFFAOYSA-N 183089 US9150546, I-200::US9688643, I-200::US9718790, I-0200 P2X purinoceptor 3 Homo sapiens 128 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183089 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183089&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821207 313634489 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504330 CCOc1ccc(cc1Cl)\N=c1/[nH]c(=O)n([C@@H](C)[C@@H](C)C(=O)OC)c(=O)n1Cc1ccc(Cl)cc1 264780 US9718790, I-0916 P2X purinoceptor 3 Homo sapiens 19.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264780 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264780&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278276 377003658 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504331 CCc1oc2ccc(cc2c1C)\N=c1/[nH]c(=O)n(CC(C)(C)C(=O)OC)c(=O)n1Cc1ccc(C)cc1 InChI=1S/C28H32N4O5/c1-7-22-18(3)21-14-20(12-13-23(21)37-22)29-25-30-26(34)32(16-28(4,5)24(33)36-6)27(35)31(25)15-19-10-8-17(2)9-11-19/h8-14H,7,15-16H2,1-6H3,(H,29,30,34) WPCLNAZJGAWSKC-UHFFFAOYSA-N 264781 US9718790, I-1575 P2X purinoceptor 3 Homo sapiens 9.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264781 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264781&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278522 377003659 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504332 CC(C)Oc1ccc(Nc2nc(=O)n(C(C)C)c(=O)n2Cc2ccc(F)cc2)cc1Cl InChI=1S/C22H24ClFN4O3/c1-13(2)28-21(29)26-20(25-17-9-10-19(18(23)11-17)31-14(3)4)27(22(28)30)12-15-5-7-16(24)8-6-15/h5-11,13-14H,12H2,1-4H3,(H,25,26,29) OWVXHUYXGFSYQY-UHFFFAOYSA-N 183090 US9150546, I-203::US9688643, I-203::US9718790, I-0203 P2X purinoceptor 3 Homo sapiens 110 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183090 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183090&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821264 313634490 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504333 COC(=O)[C@H](C)[C@H](C)n1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(Cl)c2)n(Cc2ccc(Cl)cc2)c1=O 264783 US9718790, I-0917 P2X purinoceptor 3 Homo sapiens 19.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264783 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264783&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278214 377003661 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504334 Cc1nc2ccc(cc2s1)\N=c1/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C23H22ClN5O4S/c1-13-25-17-9-8-16(10-18(17)34-13)26-20-27-21(32)29(12-23(2,3)19(30)31)22(33)28(20)11-14-4-6-15(24)7-5-14/h4-10H,11-12H2,1-3H3,(H,30,31)(H,26,27,32) RBVYUYPSEUAANG-UHFFFAOYSA-N 264784 US9718790, I-1576 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264784 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264784&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945479 377003662 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505994 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(OCC(F)F)cc2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 266430 US9718790, I-0849 P2X purinoceptor 3 Homo sapiens 78.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266430 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266430&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945257 377005301 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505995 CCOC(=O)CCn1c(=O)[nH]\c(=N/c2ccc3oc(CC)c(C)c3c2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C27H30N4O5/c1-5-22-18(4)21-15-20(11-12-23(21)36-22)28-25-29-26(33)30(14-13-24(32)35-6-2)27(34)31(25)16-19-9-7-17(3)8-10-19/h7-12,15H,5-6,13-14,16H2,1-4H3,(H,28,29,33) QNRGRCUDXLKCFM-UHFFFAOYSA-N 266431 US9718790, I-1504 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266431 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266431&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945196 377005302 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505996 OC(=O)c1cc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(CC(F)F)c(=O)n2Cc2ccc(Cl)cc2)ccn1 InChI=1S/C24H18ClF2N5O5/c25-15-3-1-14(2-4-15)12-31-22(30-23(35)32(24(31)36)13-20(26)27)29-16-5-7-17(8-6-16)37-18-9-10-28-19(11-18)21(33)34/h1-11,20H,12-13H2,(H,33,34)(H,29,30,35) UTCIHBPFZMKGTJ-UHFFFAOYSA-N 266432 US9718790, I-2248 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266432 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266432&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945510 377005303 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505997 CC(C)Oc1ccc(cc1C)\N=c1/[nH]c(=O)n([C@H]2CC[C@@H](CC2)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 266433 US9718790, I-0850 P2X purinoceptor 3 Homo sapiens 62.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266433 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266433&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020210 377005304 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505998 CCOC(=O)CCn1c(=O)[nH]\c(=N/c2ccc3nc(CC)sc3c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H24ClN5O4S/c1-3-20-27-18-10-9-17(13-19(18)35-20)26-22-28-23(32)29(12-11-21(31)34-4-2)24(33)30(22)14-15-5-7-16(25)8-6-15/h5-10,13H,3-4,11-12,14H2,1-2H3,(H,26,28,32) GZDVIALJTPXCQG-UHFFFAOYSA-N 266434 US9718790, I-1505 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266434 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266434&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945424 377005305 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505999 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cc(sn3)C(O)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C22H18ClN5O5S/c1-2-27-21(31)25-20(28(22(27)32)12-13-3-5-14(23)6-4-13)24-15-7-9-16(10-8-15)33-18-11-17(19(29)30)34-26-18/h3-11H,2,12H2,1H3,(H,29,30)(H,24,25,31) UHHZNGLGGUAOQW-UHFFFAOYSA-N 266435 US9718790, I-2249 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266435 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266435&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020155 377005306 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506000 CC(C)Oc1ccc(cc1C)\N=c1/[nH]c(=O)n([C@@H]2CC[C@@H](CC2)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 266436 US9718790, I-0851 P2X purinoceptor 3 Homo sapiens 24.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266436 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266436&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020210 377005307 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506001 CCOC(=O)CCn1c(=O)[nH]\c(=N/c2ccc3nc(CC)sc3c2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C25H27N5O4S/c1-4-21-27-19-11-10-18(14-20(19)35-21)26-23-28-24(32)29(13-12-22(31)34-5-2)25(33)30(23)15-17-8-6-16(3)7-9-17/h6-11,14H,4-5,12-13,15H2,1-3H3,(H,26,28,32) CEQCXOBVKBJSKA-UHFFFAOYSA-N 266437 US9718790, I-1506 P2X purinoceptor 3 Homo sapiens 2.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266437 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266437&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945314 377005308 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506002 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cc(ccn3)C(O)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H20ClN5O5/c1-2-29-23(33)28-22(30(24(29)34)14-15-3-5-17(25)6-4-15)27-18-7-9-19(10-8-18)35-20-13-16(21(31)32)11-12-26-20/h3-13H,2,14H2,1H3,(H,31,32)(H,27,28,33) JMSWXVHOMCSGBX-UHFFFAOYSA-N 266438 US9718790, I-2250 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266438 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266438&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020157 377005309 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506003 CC(C)Oc1ccc(cc1C)\N=c1/[nH]c(=O)n(C[C@H](O)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 266439 US9718790, I-0852 P2X purinoceptor 3 Homo sapiens 38.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266439 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266439&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020000 377005310 C02929 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506004 CCc1oc2ccc(cc2c1C)\N=c1/[nH]c(=O)n(CCC(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C24H23ClN4O5/c1-3-19-14(2)18-12-17(8-9-20(18)34-19)26-22-27-23(32)28(11-10-21(30)31)24(33)29(22)13-15-4-6-16(25)7-5-15/h4-9,12H,3,10-11,13H2,1-2H3,(H,30,31)(H,26,27,32) BYQHHIHOWTTXJZ-UHFFFAOYSA-N 266440 US9718790, I-1507 P2X purinoceptor 3 Homo sapiens 15.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266440 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266440&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945204 377005311 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506005 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccnc(c3)C(=O)NC)c(OC)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H25ClN6O5/c1-4-32-25(35)31-24(33(26(32)36)15-16-5-7-17(27)8-6-16)30-18-9-10-21(22(13-18)37-3)38-19-11-12-29-20(14-19)23(34)28-2/h5-14H,4,15H2,1-3H3,(H,28,34)(H,30,31,35) GEJLXODERDTFRZ-UHFFFAOYSA-N 266441 US9718790, I-2251 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266441 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266441&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945414 377005312 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506006 CC[C@@H](C)Oc1ccc(cc1C)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(C)cc1 266442 US9718790, I-0853 P2X purinoceptor 3 Homo sapiens 13.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266442 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266442&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020128 377005313 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506007 CCc1oc2ccc(cc2c1C)\N=c1/[nH]c(=O)n(CCC(O)=O)c(=O)n1Cc1ccc(C)cc1 InChI=1S/C25H26N4O5/c1-4-20-16(3)19-13-18(9-10-21(19)34-20)26-23-27-24(32)28(12-11-22(30)31)25(33)29(23)14-17-7-5-15(2)6-8-17/h5-10,13H,4,11-12,14H2,1-3H3,(H,30,31)(H,26,27,32) DCOBWFZYLWHCIJ-UHFFFAOYSA-N 266443 US9718790, I-1508 P2X purinoceptor 3 Homo sapiens 18.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266443 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266443&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278351 377005314 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506008 COc1ccc(CNc2nc(=O)n(Cc3ccc(Cl)cc3)\c(=N\c3ccc(OC(C)C)cc3)[nH]2)c(OC)c1 InChI=1S/C28H30ClN5O4/c1-18(2)38-23-13-10-22(11-14-23)31-27-32-26(30-16-20-7-12-24(36-3)15-25(20)37-4)33-28(35)34(27)17-19-5-8-21(29)9-6-19/h5-15,18H,16-17H2,1-4H3,(H2,30,31,32,33,35) WBHQXFSFJKQWFS-UHFFFAOYSA-N 266444 US9718790, I-2252 P2X purinoceptor 3 Homo sapiens 769 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266444 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266444&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 135121020 377005315 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506009 CC[C@@H](C)Oc1ccc(cc1)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(C)cc1 266445 US9718790, I-0854 P2X purinoceptor 3 Homo sapiens 32.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266445 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266445&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020237 377005316 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506010 CCc1nc2ccc(cc2s1)\N=c1/[nH]c(=O)n(CCC(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C22H20ClN5O4S/c1-2-18-25-16-8-7-15(11-17(16)33-18)24-20-26-21(31)27(10-9-19(29)30)22(32)28(20)12-13-3-5-14(23)6-4-13/h3-8,11H,2,9-10,12H2,1H3,(H,29,30)(H,24,26,31) OFPVPLFCZNIKNR-UHFFFAOYSA-N 266446 US9718790, I-1509 P2X purinoceptor 3 Homo sapiens 14.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266446 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266446&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278342 377005317 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506011 CC(C)Oc1ccc(cc1)\N=c1/[nH]c(=S)n(C(C)C)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C22H25ClN4O2S/c1-14(2)27-21(30)25-20(24-18-9-11-19(12-10-18)29-15(3)4)26(22(27)28)13-16-5-7-17(23)8-6-16/h5-12,14-15H,13H2,1-4H3,(H,24,25,30) SLVRFWKWHPQOLP-UHFFFAOYSA-N 266447 US9718790, I-2254 P2X purinoceptor 3 Homo sapiens 78.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266447 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266447&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 86689136 377005318 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506012 CCOC(=O)C(F)(F)Cn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(C)c2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C26H30F2N4O5/c1-6-36-22(33)26(27,28)15-32-24(34)30-23(29-20-11-12-21(18(5)13-20)37-16(2)3)31(25(32)35)14-19-9-7-17(4)8-10-19/h7-13,16H,6,14-15H2,1-5H3,(H,29,30,34) HDKNBARNXSTGDQ-UHFFFAOYSA-N 266448 US9718790, I-0855 P2X purinoceptor 3 Homo sapiens 10.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266448 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266448&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020002 377005319 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506013 CCc1nc2ccc(cc2s1)\N=c1/[nH]c(=O)n(CCC(O)=O)c(=O)n1Cc1ccc(C)cc1 InChI=1S/C23H23N5O4S/c1-3-19-25-17-9-8-16(12-18(17)33-19)24-21-26-22(31)27(11-10-20(29)30)23(32)28(21)13-15-6-4-14(2)5-7-15/h4-9,12H,3,10-11,13H2,1-2H3,(H,29,30)(H,24,26,31) YWFGFJNLJSKEEA-UHFFFAOYSA-N 266449 US9718790, I-1510 P2X purinoceptor 3 Homo sapiens 13.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266449 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266449&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945281 377005320 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506014 CC(C)Oc1ccc(cc1)-n1c(NCc2ccc(Cl)cc2)nc(=S)n(C(C)C)c1=O InChI=1S/C22H25ClN4O2S/c1-14(2)26-21(30)25-20(24-13-16-5-7-17(23)8-6-16)27(22(26)28)18-9-11-19(12-10-18)29-15(3)4/h5-12,14-15H,13H2,1-4H3,(H,24,25,30) NTJLVEZRLMXLIK-UHFFFAOYSA-N 266450 US9718790, I-2255 P2X purinoceptor 3 Homo sapiens 543 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266450 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266450&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 135121021 377005321 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506015 CCOC(=O)C(F)(F)Cn1c(=O)[nH]\c(=N/c2ccc(OCC)c(Cl)c2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C24H25ClF2N4O5/c1-4-35-19-11-10-17(12-18(19)25)28-21-29-22(33)31(14-24(26,27)20(32)36-5-2)23(34)30(21)13-16-8-6-15(3)7-9-16/h6-12H,4-5,13-14H2,1-3H3,(H,28,29,33) IAMQEZVSINSGAV-UHFFFAOYSA-N 266451 US9718790, I-0856 P2X purinoceptor 3 Homo sapiens 12.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266451 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266451&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020422 377005322 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506016 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(CC3CC3)c(Cl)c2)n(Cc2ccc(C)cc2)c1=O 266452 US9718790, I-1511 P2X purinoceptor 3 Homo sapiens 29.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266452 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266452&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020267 377005323 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506018 CC(C)Oc1ccc(cc1C)\N=c1/[nH]c(=O)n(CC(F)(F)C(O)=O)c(=O)n1Cc1ccc(C)cc1 InChI=1S/C24H26F2N4O5/c1-14(2)35-19-10-9-18(11-16(19)4)27-21-28-22(33)30(13-24(25,26)20(31)32)23(34)29(21)12-17-7-5-15(3)6-8-17/h5-11,14H,12-13H2,1-4H3,(H,31,32)(H,27,28,33) UZPMEIKVMZBLIA-UHFFFAOYSA-N 266454 US9718790, I-0857 P2X purinoceptor 3 Homo sapiens 19.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266454 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266454&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020477 377005325 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506019 Cn1cc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(CCC(O)=O)c(=O)n2Cc2ccc(Cl)cc2)ccc1=O InChI=1S/C25H22ClN5O6/c1-29-15-20(10-11-21(29)32)37-19-8-6-18(7-9-19)27-23-28-24(35)30(13-12-22(33)34)25(36)31(23)14-16-2-4-17(26)5-3-16/h2-11,15H,12-14H2,1H3,(H,33,34)(H,27,28,35) BWLCZNGCKPRKCB-UHFFFAOYSA-N 266455 US9718790, I-1512 P2X purinoceptor 3 Homo sapiens 13.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266455 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266455&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020122 377005326 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506020 CCn1c(=O)n(Cc2ccc(Cl)cc2)\c(=N\c2ccc(Oc3ccnc(O)c3)cc2)[nH]c1=S InChI=1S/C23H20ClN5O3S/c1-2-28-22(33)27-21(29(23(28)31)14-15-3-5-16(24)6-4-15)26-17-7-9-18(10-8-17)32-19-11-12-25-20(30)13-19/h3-13H,2,14H2,1H3,(H,25,30)(H,26,27,33) KGBYCFCKZMFMSL-UHFFFAOYSA-N 266456 US9718790, I-2258 P2X purinoceptor 3 Homo sapiens 3.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266456 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266456&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 88558901 377005327 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506021 CCOc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(CC(F)(F)C(O)=O)c(=O)n1Cc1ccc(C)cc1 InChI=1S/C22H21ClF2N4O5/c1-3-34-17-9-8-15(10-16(17)23)26-19-27-20(32)29(12-22(24,25)18(30)31)21(33)28(19)11-14-6-4-13(2)5-7-14/h4-10H,3,11-12H2,1-2H3,(H,30,31)(H,26,27,32) MCBAIEHOIWAFIL-UHFFFAOYSA-N 266457 US9718790, I-0858 P2X purinoceptor 3 Homo sapiens 22.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266457 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266457&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020500 377005328 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506022 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(CC3CC3)c(Cl)c2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 266458 US9718790, I-1513 P2X purinoceptor 3 Homo sapiens 10.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266458 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266458&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020306 377005329 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506023 CCn1c(=S)[nH]\c(=N/c2ccc(Oc3cncc(c3)C(=O)OC)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H22ClN5O4S/c1-3-30-24(36)29-23(31(25(30)33)15-16-4-6-18(26)7-5-16)28-19-8-10-20(11-9-19)35-21-12-17(13-27-14-21)22(32)34-2/h4-14H,3,15H2,1-2H3,(H,28,29,36) ZJPWFZQJWGZBKD-UHFFFAOYSA-N 266459 US9718790, I-2262 P2X purinoceptor 3 Homo sapiens 17.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266459 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266459&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 88558906 377005330 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506024 CCCOc1ccc(cc1)\N=c1/[nH]c(=O)n(CC(F)(F)C(=O)OCC)c(=O)n1Cc1ccc(C)cc1 InChI=1S/C25H28F2N4O5/c1-4-14-36-20-12-10-19(11-13-20)28-22-29-23(33)31(16-25(26,27)21(32)35-5-2)24(34)30(22)15-18-8-6-17(3)7-9-18/h6-13H,4-5,14-16H2,1-3H3,(H,28,29,33) ODUVIZDKESADKZ-UHFFFAOYSA-N 266460 US9718790, I-0859 P2X purinoceptor 3 Homo sapiens 17.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266460 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266460&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020410 377005331 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506025 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(OC3CC3)cc2)n(Cc2ccc(C)cc2)c1=O 266461 US9718790, I-1514 P2X purinoceptor 3 Homo sapiens 24.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266461 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266461&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020124 377005332 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506026 CCn1c(=S)[nH]\c(=N/c2ccc(Oc3cncc(c3)C(O)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H20ClN5O4S/c1-2-29-23(35)28-22(30(24(29)33)14-15-3-5-17(25)6-4-15)27-18-7-9-19(10-8-18)34-20-11-16(21(31)32)12-26-13-20/h3-13H,2,14H2,1H3,(H,31,32)(H,27,28,35) CXPVKDCJWVXHDB-UHFFFAOYSA-N 266462 US9718790, I-2263 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266462 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266462&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278652 377005333 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506027 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(CC(C)C)cc2)n(Cc2ccc(C)cc2)c1=O 266463 US9718790, I-0860 P2X purinoceptor 3 Homo sapiens 62.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266463 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266463&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020424 377005334 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506028 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccc3)nc2)n(Cc2ccc(C)cc2)c1=O 266464 US9718790, I-1515 P2X purinoceptor 3 Homo sapiens 157 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266464 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266464&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020244 377005335 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506029 CCn1c(SC)n\c(=N/c2ccc(Oc3cncc(c3)C(=O)OC)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H24ClN5O4S/c1-4-31-25(37-3)30-24(32(26(31)34)16-17-5-7-19(27)8-6-17)29-20-9-11-21(12-10-20)36-22-13-18(14-28-15-22)23(33)35-2/h5-15H,4,16H2,1-3H3/b29-24+ VZTQOQPFUIFGOK-RMLRFSFXSA-N 266465 US9718790, I-2264 P2X purinoceptor 3 Homo sapiens 558 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266465 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266465&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 77389054 377005336 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506030 CCCOc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(CCCC(=O)OCC)c(=O)n1Cc1ccc(C)cc1 InChI=1S/C26H31ClN4O5/c1-4-15-36-22-13-12-20(16-21(22)27)28-24-29-25(33)30(14-6-7-23(32)35-5-2)26(34)31(24)17-19-10-8-18(3)9-11-19/h8-13,16H,4-7,14-15,17H2,1-3H3,(H,28,29,33) YHSJNOVUWRYVPQ-UHFFFAOYSA-N 266466 US9718790, I-0861 P2X purinoceptor 3 Homo sapiens 19.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266466 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266466&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020421 377005337 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506031 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(OC3CC3)cc2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 266467 US9718790, I-1516 P2X purinoceptor 3 Homo sapiens 49.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266467 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266467&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020303 377005338 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506032 CCn1c(=O)[nH]\c(=N/c2ccc(O[C@@H]3C[C@H](N(C3)C(=O)OC(C)(C)C)C(=O)OC)cc2)n(Cc2ccc(Cl)cc2)c1=O 266468 US9718790, I-2265 P2X purinoceptor 3 Homo sapiens 299 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266468 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266468&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278344 377005339 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506033 CCOC(=O)CCCn1c(=O)[nH]\c(=N/c2ccc(OCC)c(Cl)c2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C25H29ClN4O5/c1-4-34-21-13-12-19(15-20(21)26)27-23-28-24(32)29(14-6-7-22(31)35-5-2)25(33)30(23)16-18-10-8-17(3)9-11-18/h8-13,15H,4-7,14,16H2,1-3H3,(H,27,28,32) JRSIZXREEYFGBY-UHFFFAOYSA-N 266469 US9718790, I-0862 P2X purinoceptor 3 Homo sapiens 10.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266469 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266469&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020426 377005340 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506034 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccc3)nc2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 266470 US9718790, I-1517 P2X purinoceptor 3 Homo sapiens 240 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266470 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266470&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020211 377005341 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506035 COC(=O)c1cccc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(C)c(=O)n2Cc2ccc(C)cc2)n1 InChI=1S/C25H23N5O5/c1-16-7-9-17(10-8-16)15-30-23(28-24(32)29(2)25(30)33)26-18-11-13-19(14-12-18)35-21-6-4-5-20(27-21)22(31)34-3/h4-14H,15H2,1-3H3,(H,26,28,32) RZJHSOYXIUIKIN-UHFFFAOYSA-N 266471 US9718790, I-2266 P2X purinoceptor 3 Homo sapiens 44.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266471 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266471&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021145 377005342 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506036 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc3nc(C)ccc3c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 266472 US9718790, I-0864 P2X purinoceptor 3 Homo sapiens 35.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266472 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266472&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020408 377005343 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506037 CCOC(=O)CCn1c(=O)[nH]\c(=N/c2ccc3nc(C)sc3c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H22ClN5O4S/c1-3-33-20(30)10-11-28-22(31)27-21(26-17-8-9-18-19(12-17)34-14(2)25-18)29(23(28)32)13-15-4-6-16(24)7-5-15/h4-9,12H,3,10-11,13H2,1-2H3,(H,26,27,31) XGSHOMSTHNUPGM-UHFFFAOYSA-N 266473 US9718790, I-1518 P2X purinoceptor 3 Homo sapiens 2.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266473 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266473&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020265 377005344 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506038 CCn1c(=O)[nH]\c(=N/c2ccc3nc(sc3c2)N(C)C)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C21H21ClN6O2S/c1-4-27-19(29)25-18(28(21(27)30)12-13-5-7-14(22)8-6-13)23-15-9-10-16-17(11-15)31-20(24-16)26(2)3/h5-11H,4,12H2,1-3H3,(H,23,25,29) METGYDPMLHXVIF-UHFFFAOYSA-N 266474 US9718790, I-2267 P2X purinoceptor 3 Homo sapiens 331 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266474 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266474&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021146 377005345 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506039 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(C)c2)n(Cc2ccc(Br)cc2)c1=O 266475 US9718790, I-0865 P2X purinoceptor 3 Homo sapiens 17.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266475 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266475&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020446 377005346 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506040 CCOC(=O)CCn1c(=O)[nH]\c(=N/c2ccc3nc(C)sc3c2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C24H25N5O4S/c1-4-33-21(30)11-12-28-23(31)27-22(26-18-9-10-19-20(13-18)34-16(3)25-19)29(24(28)32)14-17-7-5-15(2)6-8-17/h5-10,13H,4,11-12,14H2,1-3H3,(H,26,27,31) QLRLCKSOODOJGP-UHFFFAOYSA-N 266476 US9718790, I-1519 P2X purinoceptor 3 Homo sapiens 2.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266476 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266476&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020266 377005347 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506041 Cc1ccc(Cn2c(=O)n(C)c(=O)[nH]\c2=N/c2ccc(Oc3cccc(n3)C(O)=O)cc2)cc1 InChI=1S/C24H21N5O5/c1-15-6-8-16(9-7-15)14-29-22(27-23(32)28(2)24(29)33)25-17-10-12-18(13-11-17)34-20-5-3-4-19(26-20)21(30)31/h3-13H,14H2,1-2H3,(H,30,31)(H,25,27,32) PVUMHSVHRSYWLT-UHFFFAOYSA-N 266477 US9718790, I-2268 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266477 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266477&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020276 377005348 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506042 CCOC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(Cl)c2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C25H29ClN4O5/c1-5-34-22(31)12-13-29-24(32)28-23(27-19-10-11-21(20(26)14-19)35-16(2)3)30(25(29)33)15-18-8-6-17(4)7-9-18/h6-11,14,16H,5,12-13,15H2,1-4H3,(H,27,28,32) LMUXCBIYRWBGIA-UHFFFAOYSA-N 266478 US9718790, I-0866 P2X purinoceptor 3 Homo sapiens 2.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266478 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266478&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 86689093 377005349 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506043 Cc1nc2ccc(cc2s1)\N=c1/[nH]c(=O)n(CCC(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C21H18ClN5O4S/c1-12-23-16-7-6-15(10-17(16)32-12)24-19-25-20(30)26(9-8-18(28)29)21(31)27(19)11-13-2-4-14(22)5-3-13/h2-7,10H,8-9,11H2,1H3,(H,28,29)(H,24,25,30) IDHMEUSDOVRHAF-UHFFFAOYSA-N 266479 US9718790, I-1520 P2X purinoceptor 3 Homo sapiens 32.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266479 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266479&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020305 377005350 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506044 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(nn3)C(=O)OC)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H21ClN6O5/c1-3-30-23(33)27-22(31(24(30)34)14-15-4-6-16(25)7-5-15)26-17-8-10-18(11-9-17)36-20-13-12-19(28-29-20)21(32)35-2/h4-13H,3,14H2,1-2H3,(H,26,27,33) RHWKADCUUNQCMX-UHFFFAOYSA-N 266480 US9718790, I-2269 P2X purinoceptor 3 Homo sapiens 2.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266480 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266480&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945643 377005351 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506045 CCOC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(OCC)c(Cl)c2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C24H27ClN4O5/c1-4-33-20-11-10-18(14-19(20)25)26-22-27-23(31)28(13-12-21(30)34-5-2)24(32)29(22)15-17-8-6-16(3)7-9-17/h6-11,14H,4-5,12-13,15H2,1-3H3,(H,26,27,31) ZKURFZUSQITFQS-UHFFFAOYSA-N 266481 US9718790, I-0867 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266481 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266481&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278210 377005352 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506046 Cc1nc2ccc(cc2s1)\N=c1/[nH]c(=O)n(CCC(O)=O)c(=O)n1Cc1ccc(C)cc1 InChI=1S/C22H21N5O4S/c1-13-3-5-15(6-4-13)12-27-20(25-21(30)26(22(27)31)10-9-19(28)29)24-16-7-8-17-18(11-16)32-14(2)23-17/h3-8,11H,9-10,12H2,1-2H3,(H,28,29)(H,24,25,30) OGXUEXWYERENPK-UHFFFAOYSA-N 266482 US9718790, I-1521 P2X purinoceptor 3 Homo sapiens 22.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266482 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266482&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019937 377005353 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506047 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cncc(n3)C(=O)OC)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H21ClN6O5/c1-3-30-23(33)29-22(31(24(30)34)14-15-4-6-16(25)7-5-15)27-17-8-10-18(11-9-17)36-20-13-26-12-19(28-20)21(32)35-2/h4-13H,3,14H2,1-2H3,(H,27,29,33) HUCWWQACWSSKIJ-UHFFFAOYSA-N 266483 US9718790, I-2270 P2X purinoceptor 3 Homo sapiens <4.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266483 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266483&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021152 377005354 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506048 CC(C)Oc1ccc(cc1C)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(Br)cc1 266484 US9718790, I-0868 P2X purinoceptor 3 Homo sapiens 23.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266484 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266484&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020166 377005355 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506049 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(OC)nc3)cc2)n(Cc2ccc(C)cc2)c1=O 266485 US9718790, I-1522 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266485 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266485&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278267 377005356 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506050 COC(=O)c1cccc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(C)c(=O)n2Cc2ccc(Cl)cc2)n1 InChI=1S/C24H20ClN5O5/c1-29-23(32)28-22(30(24(29)33)14-15-6-8-16(25)9-7-15)26-17-10-12-18(13-11-17)35-20-5-3-4-19(27-20)21(31)34-2/h3-13H,14H2,1-2H3,(H,26,28,32) KVDBQJACGSCPPJ-UHFFFAOYSA-N 266486 US9718790, I-2271 P2X purinoceptor 3 Homo sapiens 36.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266486 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266486&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278234 377005357 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506051 CNC(=O)[C@H](CCO)n1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O 266487 US9718790, I-0869 P2X purinoceptor 3 Homo sapiens 574 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266487 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266487&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945230 377005358 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506052 CCOC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(OC)nc3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C27H26ClN5O6/c1-3-38-24(34)14-15-32-26(35)31-25(33(27(32)36)17-18-4-6-19(28)7-5-18)30-20-8-10-21(11-9-20)39-22-12-13-23(37-2)29-16-22/h4-13,16H,3,14-15,17H2,1-2H3,(H,30,31,35) XCOXPRRHOANODN-UHFFFAOYSA-N 266488 US9718790, I-1523 P2X purinoceptor 3 Homo sapiens 3.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266488 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266488&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019765 377005359 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506053 Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(n3)C(O)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H18ClN5O5/c1-28-22(32)27-21(29(23(28)33)13-14-5-7-15(24)8-6-14)25-16-9-11-17(12-10-16)34-19-4-2-3-18(26-19)20(30)31/h2-12H,13H2,1H3,(H,30,31)(H,25,27,32) HIZKGMJCRLPZOS-UHFFFAOYSA-N 266489 US9718790, I-2272 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266489 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266489&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278432 377005360 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506054 CNC(=O)[C@@H](CCO)n1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O 266490 US9718790, I-0870 P2X purinoceptor 3 Homo sapiens 530 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266490 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266490&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278467 377005361 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506055 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(CC(C)(C)O)c(Cl)c2)n(Cc2ccc(C)cc2)c1=O 266491 US9718790, I-1527 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266491 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266491&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020143 377005362 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506056 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(nn3)C(O)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H19ClN6O5/c1-2-29-22(33)26-21(30(23(29)34)13-14-3-5-15(24)6-4-14)25-16-7-9-17(10-8-16)35-19-12-11-18(20(31)32)27-28-19/h3-12H,2,13H2,1H3,(H,31,32)(H,25,26,33) BYESDPBWDIERSZ-UHFFFAOYSA-N 266492 US9718790, I-2273 P2X purinoceptor 3 Homo sapiens 12.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266492 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266492&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020176 377005363 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506057 CCCOc1ccc(cc1)\N=c1/[nH]c(=O)n(CC(F)(F)C(O)=O)c(=O)n1Cc1ccc(C)cc1 InChI=1S/C23H24F2N4O5/c1-3-12-34-18-10-8-17(9-11-18)26-20-27-21(32)29(14-23(24,25)19(30)31)22(33)28(20)13-16-6-4-15(2)5-7-16/h4-11H,3,12-14H2,1-2H3,(H,30,31)(H,26,27,32) MDRICZISCBRRNG-UHFFFAOYSA-N 266493 US9718790, I-0871 P2X purinoceptor 3 Homo sapiens 40.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266493 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266493&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020802 377005364 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506058 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(CC(C)(C)F)c(Cl)c2)n(Cc2ccc(C)cc2)c1=O 266494 US9718790, I-1528 P2X purinoceptor 3 Homo sapiens 32.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266494 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266494&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020213 377005365 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506059 Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(n3)C(N)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H19ClN6O4/c1-29-22(32)28-21(30(23(29)33)13-14-5-7-15(24)8-6-14)26-16-9-11-17(12-10-16)34-19-4-2-3-18(27-19)20(25)31/h2-12H,13H2,1H3,(H2,25,31)(H,26,28,32) FNGSUHHEZLTAHV-UHFFFAOYSA-N 266495 US9718790, I-2274 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266495 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266495&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945675 377005366 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506060 CC(C)Cc1ccc(cc1)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(C)cc1 266496 US9718790, I-0872 P2X purinoceptor 3 Homo sapiens 81.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266496 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266496&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020805 377005367 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504335 CC(C)Oc1ccc(Nc2nc(=O)n(C(C)C)c(=O)n2Cc2ccc(F)cc2)cc1C(F)(F)F InChI=1S/C23H24F4N4O3/c1-13(2)31-21(32)29-20(30(22(31)33)12-15-5-7-16(24)8-6-15)28-17-9-10-19(34-14(3)4)18(11-17)23(25,26)27/h5-11,13-14H,12H2,1-4H3,(H,28,29,32) PTPBSADSFRUMGB-UHFFFAOYSA-N 183091 US9150546, I-204::US9688643, I-204::US9718790, I-0204 P2X purinoceptor 3 Homo sapiens 558 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183091 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183091&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821243 313634491 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504336 CCOC(=O)C1(Cn2c(=O)[nH]\c(=N/c3ccc(OCC)c(Cl)c3)n(Cc3ccc(Cl)cc3)c2=O)CC1 InChI=1S/C25H26Cl2N4O5/c1-3-35-20-10-9-18(13-19(20)27)28-22-29-23(33)31(15-25(11-12-25)21(32)36-4-2)24(34)30(22)14-16-5-7-17(26)8-6-16/h5-10,13H,3-4,11-12,14-15H2,1-2H3,(H,28,29,33) GWEPMWQYLPQVBL-UHFFFAOYSA-N 264786 US9718790, I-0918 P2X purinoceptor 3 Homo sapiens 14.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264786 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264786&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021020 377003664 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504337 Cc1nc2ccc(cc2s1)\N=c1/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n1Cc1ccc(C)cc1 InChI=1S/C24H25N5O4S/c1-14-5-7-16(8-6-14)12-28-21(26-17-9-10-18-19(11-17)34-15(2)25-18)27-22(32)29(23(28)33)13-24(3,4)20(30)31/h5-11H,12-13H2,1-4H3,(H,30,31)(H,26,27,32) HHSFAKQIZFCAJW-UHFFFAOYSA-N 264787 US9718790, I-1577 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264787 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264787&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945465 377003665 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504338 CC(C)Oc1ccc(Nc2nc(=O)n(C(C)C)c(=O)n2Cc2ccc(C)c(F)c2)cc1 InChI=1S/C23H27FN4O3/c1-14(2)28-22(29)26-21(25-18-8-10-19(11-9-18)31-15(3)4)27(23(28)30)13-17-7-6-16(5)20(24)12-17/h6-12,14-15H,13H2,1-5H3,(H,25,26,29) VXLKRVZZJMGIRW-UHFFFAOYSA-N 183092 US9150546, I-217::US9688643, I-217::US9718790, I-0217 P2X purinoceptor 3 Homo sapiens 268 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183092 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183092&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821277 313634492 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504339 CCCOc1ccc(cc1)\N=c1/[nH]c(=O)n(CC2(CC2)C(=O)OCC)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C26H29ClN4O5/c1-3-15-36-21-11-9-20(10-12-21)28-23-29-24(33)31(17-26(13-14-26)22(32)35-4-2)25(34)30(23)16-18-5-7-19(27)8-6-18/h5-12H,3-4,13-17H2,1-2H3,(H,28,29,33) VBOQDIFLYMHORZ-UHFFFAOYSA-N 264789 US9718790, I-0919 P2X purinoceptor 3 Homo sapiens 14.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264789 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264789&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020994 377003667 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504340 CCc1nc2ccc(cc2s1)\N=c1/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C24H24ClN5O4S/c1-4-19-27-17-10-9-16(11-18(17)35-19)26-21-28-22(33)30(13-24(2,3)20(31)32)23(34)29(21)12-14-5-7-15(25)8-6-14/h5-11H,4,12-13H2,1-3H3,(H,31,32)(H,26,28,33) VVJPHDFJYJFKQZ-UHFFFAOYSA-N 264790 US9718790, I-1578 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264790 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264790&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945460 377003668 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504341 CC(C)Oc1ccc(Nc2nc(=O)n(C(C)C)c(=O)n2Cc2ccc(C)c(c2)[N+]([O-])=O)cc1 InChI=1S/C23H27N5O5/c1-14(2)27-22(29)25-21(24-18-8-10-19(11-9-18)33-15(3)4)26(23(27)30)13-17-7-6-16(5)20(12-17)28(31)32/h6-12,14-15H,13H2,1-5H3,(H,24,25,29) DOEKZSQEACUAEJ-UHFFFAOYSA-N 183093 US9150546, I-218::US9688643, I-218::US9718790, I-0218 P2X purinoceptor 3 Homo sapiens 505 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183093 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183093&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 119099065 313634493 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504342 CCCOc1ccc(cc1)\N=c1/[nH]c(=O)n([C@@H](C)[C@@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 264792 US9718790, I-0920 P2X purinoceptor 3 Homo sapiens 37.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264792 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264792&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020999 377003670 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504343 CC(C)Cc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(C[C@H](C)CO)c(=O)n1Cc1ccc(C)cc1 264793 US9718790, I-1579 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264793 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264793&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278363 377003671 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504344 COC(=O)c1ccc(Nc2nc(=O)n(C(C)C)c(=O)n2Cc2ccc(F)cc2)cc1 InChI=1S/C21H21FN4O4/c1-13(2)26-20(28)24-19(23-17-10-6-15(7-11-17)18(27)30-3)25(21(26)29)12-14-4-8-16(22)9-5-14/h4-11,13H,12H2,1-3H3,(H,23,24,28) YCUSQGGRWIFGSQ-UHFFFAOYSA-N 183094 US9150546, I-221::US9688643, I-221::US9718790, I-0221 P2X purinoceptor 3 Homo sapiens 276 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183094 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183094&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821180 313634494 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504345 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc(OCC3CC3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 264795 US9718790, I-0921 P2X purinoceptor 3 Homo sapiens 30.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264795 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264795&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945367 377003673 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504346 CCc1nc2ccc(cc2s1)\N=c1/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n1Cc1ccc(C)cc1 InChI=1S/C25H27N5O4S/c1-5-20-27-18-11-10-17(12-19(18)35-20)26-22-28-23(33)30(14-25(3,4)21(31)32)24(34)29(22)13-16-8-6-15(2)7-9-16/h6-12H,5,13-14H2,1-4H3,(H,31,32)(H,26,28,33) IUSYYYKDTWCANC-UHFFFAOYSA-N 264796 US9718790, I-1580 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264796 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264796&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945587 377003674 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504347 CC(C)n1c(=O)nc(NC(C)c2ccc(Cl)cc2)n(Cc2ccc(F)cc2)c1=O InChI=1S/C21H22ClFN4O2/c1-13(2)27-20(28)25-19(24-14(3)16-6-8-17(22)9-7-16)26(21(27)29)12-15-4-10-18(23)11-5-15/h4-11,13-14H,12H2,1-3H3,(H,24,25,28) AXDGKTCQGHHSCD-UHFFFAOYSA-N 183095 US9150546, I-223::US9688643, I-223::US9718790, I-0223 P2X purinoceptor 3 Homo sapiens 909 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183095 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183095&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821409 313634495 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504348 CCOc1ccc(cc1Cl)\N=c1/[nH]c(=O)n([C@@H](C)[C@@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 264798 US9718790, I-0922 P2X purinoceptor 3 Homo sapiens 29.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264798 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264798&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945206 377003676 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504349 CCc1oc2ccc(cc2c1C)\N=c1/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C26H27ClN4O5/c1-5-20-15(2)19-12-18(10-11-21(19)36-20)28-23-29-24(34)31(14-26(3,4)22(32)33)25(35)30(23)13-16-6-8-17(27)9-7-16/h6-12H,5,13-14H2,1-4H3,(H,32,33)(H,28,29,34) UBXJRUXGBJPXHA-UHFFFAOYSA-N 264799 US9718790, I-1581 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264799 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264799&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945482 377003677 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504350 CC(C)Oc1ccc(Nc2nc(=O)n(C(C)C)c(=O)n2Cc2ccc(F)cc2)cc1C#N InChI=1S/C23H24FN5O3/c1-14(2)29-22(30)27-21(28(23(29)31)13-16-5-7-18(24)8-6-16)26-19-9-10-20(32-15(3)4)17(11-19)12-25/h5-11,14-15H,13H2,1-4H3,(H,26,27,30) RBEZCVPCKGYRNI-UHFFFAOYSA-N 183096 US9150546, I-227::US9688643, I-227::US9718790, I-0227 P2X purinoceptor 3 Homo sapiens 910 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183096 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183096&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821362 313634496 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504351 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n([C@@H](C)[C@@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 264801 US9718790, I-0923 P2X purinoceptor 3 Homo sapiens 15.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264801 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264801&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945288 377003679 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504352 CCc1oc2ccc(cc2c1C)\N=c1/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n1Cc1ccc(C)cc1 InChI=1S/C27H30N4O5/c1-6-21-17(3)20-13-19(11-12-22(20)36-21)28-24-29-25(34)31(15-27(4,5)23(32)33)26(35)30(24)14-18-9-7-16(2)8-10-18/h7-13H,6,14-15H2,1-5H3,(H,32,33)(H,28,29,34) OPMOFQZSNIGAJS-UHFFFAOYSA-N 264802 US9718790, I-1582 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264802 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264802&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278347 377003680 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504353 CC(C)Oc1ccc(Nc2nc(=O)n(C(C)C)c(=O)n2Cc2ccc(Cl)cc2)cc1Cl InChI=1S/C22H24Cl2N4O3/c1-13(2)28-21(29)26-20(25-17-9-10-19(18(24)11-17)31-14(3)4)27(22(28)30)12-15-5-7-16(23)8-6-15/h5-11,13-14H,12H2,1-4H3,(H,25,26,29) VRNDXKXJUGXSQA-UHFFFAOYSA-N 183097 US9150546, I-228::US9688643, I-228::US9718790, I-0228 P2X purinoceptor 3 Homo sapiens 31.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183097 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183097&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821066 313634497 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504354 CCOc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(CC2(CC2)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C23H22Cl2N4O5/c1-2-34-18-8-7-16(11-17(18)25)26-20-27-21(32)29(13-23(9-10-23)19(30)31)22(33)28(20)12-14-3-5-15(24)6-4-14/h3-8,11H,2,9-10,12-13H2,1H3,(H,30,31)(H,26,27,32) RHXINYYGHBGPEY-UHFFFAOYSA-N 264804 US9718790, I-0924 P2X purinoceptor 3 Homo sapiens 30.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264804 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264804&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278474 377003682 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504355 CCn1c(C)nc2cc(ccc12)\N=c1/[nH]c(=O)n([C@@H](C)[C@@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 264805 US9718790, I-1583 P2X purinoceptor 3 Homo sapiens 332 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264805 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264805&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019797 377003683 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504356 CC(C)Oc1ccc(Nc2nc(=O)n(C(C)C)c(=O)n2Cc2ccc(Cl)cn2)cc1Cl InChI=1S/C21H23Cl2N5O3/c1-12(2)28-20(29)26-19(25-15-7-8-18(17(23)9-15)31-13(3)4)27(21(28)30)11-16-6-5-14(22)10-24-16/h5-10,12-13H,11H2,1-4H3,(H,25,26,29) AVXMYJGDEUEZIL-UHFFFAOYSA-N 183098 US9150546, I-234::US9688643, I-234::US9718790, I-0234 P2X purinoceptor 3 Homo sapiens 298 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183098 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183098&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821195 313634498 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504357 CCCOc1ccc(cc1)\N=c1/[nH]c(=O)n(CC2(CC2)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C24H25ClN4O5/c1-2-13-34-19-9-7-18(8-10-19)26-21-27-22(32)29(15-24(11-12-24)20(30)31)23(33)28(21)14-16-3-5-17(25)6-4-16/h3-10H,2,11-15H2,1H3,(H,30,31)(H,26,27,32) WYWVLXVLESCLFT-UHFFFAOYSA-N 264807 US9718790, I-0925 P2X purinoceptor 3 Homo sapiens 59.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264807 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264807&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278168 377003685 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504358 CC(C)c1nc2ccc(cc2s1)\N=c1/[nH]c(=O)n([C@@H](C)[C@@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 264808 US9718790, I-1585 P2X purinoceptor 3 Homo sapiens 14.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264808 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264808&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278364 377003686 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504359 CC(C)Oc1ccc(Nc2nc(=O)n(C(C)C)c(=O)n2Cc2ccc(Cl)nc2)cc1Cl InChI=1S/C21H23Cl2N5O3/c1-12(2)28-20(29)26-19(25-15-6-7-17(16(22)9-15)31-13(3)4)27(21(28)30)11-14-5-8-18(23)24-10-14/h5-10,12-13H,11H2,1-4H3,(H,25,26,29) OKKVOHSWYVTAHO-UHFFFAOYSA-N 183099 US9150546, I-235::US9688643, I-235::US9718790, I-0235 P2X purinoceptor 3 Homo sapiens 985 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183099 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183099&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821064 313634499 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504360 CCCOc1ccc(cc1)\N=c1/[nH]c(=O)n([C@@H](C)[C@@H](C)C(=O)OC)c(=O)n1Cc1ccc(C)cc1 264810 US9718790, I-0926 P2X purinoceptor 3 Homo sapiens 31.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264810 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264810&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278277 377003688 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504361 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc3nc(sc3c2)C2CC2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 264811 US9718790, I-1586 P2X purinoceptor 3 Homo sapiens 13.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264811 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264811&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945439 377003689 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504362 COCCOc1ccc(Nc2nc(=O)n(C(C)C)c(=O)n2Cc2ccc(Cl)cc2)cc1Cl InChI=1S/C22H24Cl2N4O4/c1-14(2)28-21(29)26-20(27(22(28)30)13-15-4-6-16(23)7-5-15)25-17-8-9-19(18(24)12-17)32-11-10-31-3/h4-9,12,14H,10-11,13H2,1-3H3,(H,25,26,29) IAQHVVYKMDVUFT-UHFFFAOYSA-N 183100 US9150546, I-237::US9688643, I-237::US9718790, I-0237 P2X purinoceptor 3 Homo sapiens 230 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183100 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183100&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821247 313634500 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504363 COC(=O)[C@H](C)[C@H](C)n1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(C)c2)n(Cc2ccc(C)cc2)c1=O 264813 US9718790, I-0927 P2X purinoceptor 3 Homo sapiens 21.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264813 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264813&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945267 377003691 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504364 COc1ccc2cc(ccc2n1)\N=c1/[nH]c(=O)n([C@@H](C)[C@@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 264814 US9718790, I-1587 P2X purinoceptor 3 Homo sapiens 38.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264814 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264814&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020902 377003692 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504365 COC(=O)c1ccc(Nc2nc(=O)n(C(C)C)c(=O)n2Cc2ccc(F)cc2)cc1Cl InChI=1S/C21H20ClFN4O4/c1-12(2)27-20(29)25-19(24-15-8-9-16(17(22)10-15)18(28)31-3)26(21(27)30)11-13-4-6-14(23)7-5-13/h4-10,12H,11H2,1-3H3,(H,24,25,29) UPIQRRIDCVZSEU-UHFFFAOYSA-N 183101 US9150546, I-238::US9688643, I-238::US9718790, I-0238 P2X purinoceptor 3 Homo sapiens 658 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183101 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183101&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76820978 313634501 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504366 COC(=O)[C@H](C)[C@H](C)n1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(Cl)c2)n(Cc2ccc(C)cc2)c1=O 264816 US9718790, I-0928 P2X purinoceptor 3 Homo sapiens 14.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264816 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264816&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020810 377003694 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504367 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2cc(Cl)c3oc(C)cc3c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 264817 US9718790, I-1588 P2X purinoceptor 3 Homo sapiens 67.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264817 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264817&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945225 377003695 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504368 CC(C)n1c(=O)nc(Nc2ccc(OC3CCOCC3)c(Cl)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H26Cl2N4O4/c1-15(2)30-23(31)28-22(29(24(30)32)14-16-3-5-17(25)6-4-16)27-18-7-8-21(20(26)13-18)34-19-9-11-33-12-10-19/h3-8,13,15,19H,9-12,14H2,1-2H3,(H,27,28,31) DDNUNYHYRGZFMC-UHFFFAOYSA-N 183102 US9150546, I-239::US9688643, I-239::US9718790, I-0239 P2X purinoceptor 3 Homo sapiens 116 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183102 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183102&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821040 313634502 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504369 CCCOc1ccc(cc1)\N=c1/[nH]c(=O)n([C@@H](C)[C@@H](C)C(O)=O)c(=O)n1Cc1ccc(C)cc1 264819 US9718790, I-0929 P2X purinoceptor 3 Homo sapiens 45.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264819 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264819&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278536 377003697 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504370 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc3ncsc3c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 264820 US9718790, I-1589 P2X purinoceptor 3 Homo sapiens 158 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264820 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264820&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020916 377003698 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504371 CC(C)n1c(=O)nc(Nc2ccc3oc(=O)[nH]c3c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C20H18ClN5O4/c1-11(2)26-18(27)24-17(22-14-7-8-16-15(9-14)23-19(28)30-16)25(20(26)29)10-12-3-5-13(21)6-4-12/h3-9,11H,10H2,1-2H3,(H,23,28)(H,22,24,27) AMVBFIORCQGGGL-UHFFFAOYSA-N 264821 US9718790, I-0249 P2X purinoceptor 3 Homo sapiens 953 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264821 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264821&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821001 377003699 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504372 CC(C)Oc1ccc(cc1C)\N=c1/[nH]c(=O)n([C@@H](C)[C@@H](C)C(O)=O)c(=O)n1Cc1ccc(C)cc1 264822 US9718790, I-0930 P2X purinoceptor 3 Homo sapiens 30.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264822 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264822&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278278 377003700 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504373 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc3sccc3c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 264823 US9718790, I-1590 P2X purinoceptor 3 Homo sapiens 998 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264823 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264823&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020918 377003701 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504374 CCOC(=O)COc1ccc(Nc2nc(=O)n(C(C)C)c(=O)n2Cc2ccc(Cl)cc2)cc1Cl InChI=1S/C23H24Cl2N4O5/c1-4-33-20(30)13-34-19-10-9-17(11-18(19)25)26-21-27-22(31)29(14(2)3)23(32)28(21)12-15-5-7-16(24)8-6-15/h5-11,14H,4,12-13H2,1-3H3,(H,26,27,31) YECJAZONJNUKOF-UHFFFAOYSA-N 183104 US9150546, I-241::US9688643, I-241::US9718790, I-0241 P2X purinoceptor 3 Homo sapiens 447 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183104 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183104&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821187 313634504 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504375 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n([C@@H](C)[C@@H](C)C(O)=O)c(=O)n1Cc1ccc(C)cc1 264825 US9718790, I-0931 P2X purinoceptor 3 Homo sapiens 12.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264825 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264825&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 89666605 377003703 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504376 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccn(C)c(=O)c3)cc2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 264826 US9718790, I-1595 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264826 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264826&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278270 377003704 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504377 CC(C)n1c(=O)nc(Nc2ccc(OC3CCNCC3)c(Cl)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H27Cl2N5O3/c1-15(2)31-23(32)29-22(30(24(31)33)14-16-3-5-17(25)6-4-16)28-18-7-8-21(20(26)13-18)34-19-9-11-27-12-10-19/h3-8,13,15,19,27H,9-12,14H2,1-2H3,(H,28,29,32) LBCWOSHEBIVJGF-UHFFFAOYSA-N 183105 US9150546, I-242::US9688643, I-242::US9718790, I-0242 P2X purinoceptor 3 Homo sapiens 787 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183105 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183105&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76820942 313634505 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504378 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(O[C@H](C)C(F)(F)F)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 264828 US9718790, I-0932 P2X purinoceptor 3 Homo sapiens 21.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264828 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264828&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019553 377003706 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504379 OCCCn1c(=O)[nH]\c(=N/c2ccc(Oc3cncc(F)c3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H21ClFN5O4/c25-17-4-2-16(3-5-17)15-31-22(29-23(33)30(24(31)34)10-1-11-32)28-19-6-8-20(9-7-19)35-21-12-18(26)13-27-14-21/h2-9,12-14,32H,1,10-11,15H2,(H,28,29,33) LDSABWZEHRISNP-UHFFFAOYSA-N 264829 US9718790, I-1596 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264829 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264829&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945313 377003707 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504380 COc1ccc(Nc2nc(=O)n(C(C)C)c(=O)n2Cc2ccc(Cl)cc2)cc1Cl InChI=1S/C20H20Cl2N4O3/c1-12(2)26-19(27)24-18(23-15-8-9-17(29-3)16(22)10-15)25(20(26)28)11-13-4-6-14(21)7-5-13/h4-10,12H,11H2,1-3H3,(H,23,24,27) MOCLUEIBJVFEID-UHFFFAOYSA-N 183106 US9150546, I-243::US9688643, I-243::US9718790, I-0243 P2X purinoceptor 3 Homo sapiens 450 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183106 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183106&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821167 313634506 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504381 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(O[C@@H](C)C(F)(F)F)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 264831 US9718790, I-0933 P2X purinoceptor 3 Homo sapiens 82.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264831 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264831&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019554 377003709 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504382 Cc1ccc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(CCCO)c(=O)n2Cc2ccc(Cl)cc2)cn1 InChI=1S/C25H24ClN5O4/c1-17-3-10-22(15-27-17)35-21-11-8-20(9-12-21)28-23-29-24(33)30(13-2-14-32)25(34)31(23)16-18-4-6-19(26)7-5-18/h3-12,15,32H,2,13-14,16H2,1H3,(H,28,29,33) XKZADTSBVZYANT-UHFFFAOYSA-N 264832 US9718790, I-1597 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264832 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264832&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278373 377003710 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504383 CC(C)Oc1ccc(Nc2nc(=O)n(C(C)C)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C22H24ClFN4O3/c1-13(2)28-21(29)26-20(25-17-9-10-19(18(24)11-17)31-14(3)4)27(22(28)30)12-15-5-7-16(23)8-6-15/h5-11,13-14H,12H2,1-4H3,(H,25,26,29) NEEKIVKPSARQCC-UHFFFAOYSA-N 183107 US9150546, I-244::US9688643, I-244::US9718790, I-0244 P2X purinoceptor 3 Homo sapiens 45.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183107 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183107&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821359 313634507 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504384 OC(=O)C1(Cn2c(=O)[nH]\c(=N/c3ccc(OCC4CC4)cc3)n(Cc3ccc(Cl)cc3)c2=O)CC1 InChI=1S/C25H25ClN4O5/c26-18-5-3-16(4-6-18)13-29-22(27-19-7-9-20(10-8-19)35-14-17-1-2-17)28-23(33)30(24(29)34)15-25(11-12-25)21(31)32/h3-10,17H,1-2,11-15H2,(H,31,32)(H,27,28,33) OOXZYIGGLPPDOQ-UHFFFAOYSA-N 264834 US9718790, I-0934 P2X purinoceptor 3 Homo sapiens 57.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264834 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264834&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019586 377003712 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504385 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccnc(C)c3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H22ClN5O3/c1-3-29-23(31)28-22(30(24(29)32)15-17-4-6-18(25)7-5-17)27-19-8-10-20(11-9-19)33-21-12-13-26-16(2)14-21/h4-14H,3,15H2,1-2H3,(H,27,28,31) VJBKXOPJQFHZGK-UHFFFAOYSA-N 264835 US9718790, I-1598 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264835 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264835&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945478 377003713 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504386 CC(C)Oc1ccc(Nc2nc(=O)n(C(C)C)c(=O)n2Cc2ccc(Cl)cc2)cc1C#N InChI=1S/C23H24ClN5O3/c1-14(2)29-22(30)27-21(28(23(29)31)13-16-5-7-18(24)8-6-16)26-19-9-10-20(32-15(3)4)17(11-19)12-25/h5-11,14-15H,13H2,1-4H3,(H,26,27,30) XNSXTWGZTGQSMH-UHFFFAOYSA-N 183108 US9150546, I-245::US9688643, I-245::US9718790, I-0245 P2X purinoceptor 3 Homo sapiens 168 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183108 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183108&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76820964 313634508 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504387 CC(C)Oc1ccc(cc1C)\N=c1/[nH]c(=O)n(CC2(CC2)C(O)=O)c(=O)n1Cc1ccc(C)cc1 InChI=1S/C26H30N4O5/c1-16(2)35-21-10-9-20(13-18(21)4)27-23-28-24(33)30(15-26(11-12-26)22(31)32)25(34)29(23)14-19-7-5-17(3)6-8-19/h5-10,13,16H,11-12,14-15H2,1-4H3,(H,31,32)(H,27,28,33) JZKORLMLLSDGIU-UHFFFAOYSA-N 264837 US9718790, I-0935 P2X purinoceptor 3 Homo sapiens 38.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264837 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264837&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019564 377003715 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504388 Cc1cc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(CCCO)c(=O)n2Cc2ccc(Cl)cc2)ccn1 InChI=1S/C25H24ClN5O4/c1-17-15-22(11-12-27-17)35-21-9-7-20(8-10-21)28-23-29-24(33)30(13-2-14-32)25(34)31(23)16-18-3-5-19(26)6-4-18/h3-12,15,32H,2,13-14,16H2,1H3,(H,28,29,33) AGIPWEQDZLIMDN-UHFFFAOYSA-N 264838 US9718790, I-1599 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264838 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264838&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945191 377003716 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504389 CC(C)n1c(=O)nc(Nc2ccc3[nH]c(=O)oc3c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C20H18ClN5O4/c1-11(2)26-18(27)24-17(22-14-7-8-15-16(9-14)30-19(28)23-15)25(20(26)29)10-12-3-5-13(21)6-4-12/h3-9,11H,10H2,1-2H3,(H,23,28)(H,22,24,27) BRLFUVYLTKDYOS-UHFFFAOYSA-N 183109 US9150546, I-246::US9688643, I-246::US9718790, I-0246 P2X purinoceptor 3 Homo sapiens 996 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183109 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183109&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 77888198 313634509 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504390 CC[C@@H](C)Oc1ccc(cc1)\N=c1/[nH]c(=O)n([C@H](C)CC(O)=O)c(=O)n1Cc1ccc(C)cc1 264840 US9718790, I-0936 P2X purinoceptor 3 Homo sapiens 65.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264840 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264840&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278279 377003717 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504391 CNC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(O)nc3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H23ClN6O5/c1-27-21(33)12-13-31-24(35)30-23(32(25(31)36)15-16-2-4-17(26)5-3-16)29-18-6-8-19(9-7-18)37-20-10-11-22(34)28-14-20/h2-11,14H,12-13,15H2,1H3,(H,27,33)(H,28,34)(H,29,30,35) NAJVUIOQDVSJGS-UHFFFAOYSA-N 264841 US9718790, I-1600 P2X purinoceptor 3 Homo sapiens 11.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264841 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264841&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945580 377003718 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504392 COC(=O)c1ccc(Nc2nc(=O)n(C(C)C)c(=O)n2Cc2ccc(Cl)cc2)cc1 InChI=1S/C21H21ClN4O4/c1-13(2)26-20(28)24-19(23-17-10-6-15(7-11-17)18(27)30-3)25(21(26)29)12-14-4-8-16(22)9-5-14/h4-11,13H,12H2,1-3H3,(H,23,24,28) UDKRZHKBWBJIRH-UHFFFAOYSA-N 183110 US9150546, I-248::US9688643, I-248::US9718790, I-0248 P2X purinoceptor 3 Homo sapiens 420 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183110 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183110&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821342 313634510 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504393 CC[C@@H](C)Oc1ccc(cc1C)\N=c1/[nH]c(=O)n([C@H](C)CC(O)=O)c(=O)n1Cc1ccc(C)cc1 264843 US9718790, I-0937 P2X purinoceptor 3 Homo sapiens 22.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264843 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264843&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945009 377003720 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504394 CNC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(O)nc3)cc2)n(Cc2ccc(C)cc2)c1=O 264844 US9718790, I-1601 P2X purinoceptor 3 Homo sapiens 24.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264844 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264844&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945238 377003721 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504395 CC(C)Oc1ccc(Nc2nc(=O)n(C(C)C)c(=O)n2Cc2ccc(Cl)s2)cc1F InChI=1S/C20H22ClFN4O3S/c1-11(2)26-19(27)24-18(25(20(26)28)10-14-6-8-17(21)30-14)23-13-5-7-16(15(22)9-13)29-12(3)4/h5-9,11-12H,10H2,1-4H3,(H,23,24,27) VRGLWZSDHZCAOI-UHFFFAOYSA-N 183111 US9150546, I-254::US9688643, I-254::US9718790, I-0254 P2X purinoceptor 3 Homo sapiens 144 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183111 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183111&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821021 313634511 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504396 CC[C@@H](C)Oc1ccc(cc1C)\N=c1/[nH]c(=O)n([C@H](C)CC(=O)OC)c(=O)n1Cc1ccc(C)cc1 264846 US9718790, I-0938 P2X purinoceptor 3 Homo sapiens 35.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264846 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264846&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278475 377003723 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504397 COC(=O)Cn1c(=O)[nH]\c(=N/c2ccc3nc(C)sc3c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C21H18ClN5O4S/c1-12-23-16-8-7-15(9-17(16)32-12)24-19-25-20(29)27(11-18(28)31-2)21(30)26(19)10-13-3-5-14(22)6-4-13/h3-9H,10-11H2,1-2H3,(H,24,25,29) FUSQNMYKEQLYES-UHFFFAOYSA-N 264847 US9718790, I-1602 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264847 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264847&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020904 377003724 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504398 CC(C)NC(=O)c1ccc(Nc2nc(=O)n(C(C)C)c(=O)n2Cc2ccc(Cl)cc2)cc1 InChI=1S/C23H26ClN5O3/c1-14(2)25-20(30)17-7-11-19(12-8-17)26-21-27-22(31)29(15(3)4)23(32)28(21)13-16-5-9-18(24)10-6-16/h5-12,14-15H,13H2,1-4H3,(H,25,30)(H,26,27,31) SIGZERSAIQXHMB-UHFFFAOYSA-N 183112 US9150546, I-255::US9688643, I-255::US9718790, I-0255 P2X purinoceptor 3 Homo sapiens 520 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183112 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183112&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821432 313634512 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504399 CC[C@@H](C)Oc1ccc(cc1)\N=c1/[nH]c(=O)n([C@H](C)CC(=O)OC)c(=O)n1Cc1ccc(C)cc1 264849 US9718790, I-0939 P2X purinoceptor 3 Homo sapiens 34.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264849 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264849&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945208 377003726 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504400 Cc1nc2ccc(cc2s1)\N=c1/[nH]c(=O)n(C[C@H]2COC(C)(C)O2)c(=O)n1Cc1ccc(Cl)cc1 264850 US9718790, I-1603 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264850 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264850&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020905 377003727 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504931 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccnc(CO)c3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H22ClN5O4/c1-2-29-23(32)28-22(30(24(29)33)14-16-3-5-17(25)6-4-16)27-18-7-9-20(10-8-18)34-21-11-12-26-19(13-21)15-31/h3-13,31H,2,14-15H2,1H3,(H,27,28,32) VDUHETRBDKMMLI-UHFFFAOYSA-N 265378 US9718790, I-1844 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265378 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265378&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019975 377004253 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506061 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(cc2)-c2noc(C)n2)n(Cc2ccc(Cl)cc2)c1=O 266497 US9718790, I-1529 P2X purinoceptor 3 Homo sapiens 26.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266497 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266497&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278345 377005368 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506062 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(nc3)C(=O)OC)cc2)n(Cc2ccc(Cl)cn2)c1=O InChI=1S/C24H21ClN6O5/c1-3-30-23(33)29-22(31(24(30)34)14-17-5-4-15(25)12-26-17)28-16-6-8-18(9-7-16)36-19-10-11-20(27-13-19)21(32)35-2/h4-13H,3,14H2,1-2H3,(H,28,29,33) RXVGUFQNCOSTAC-UHFFFAOYSA-N 266498 US9718790, I-2275 P2X purinoceptor 3 Homo sapiens 10.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266498 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266498&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945537 377005369 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506063 CCCOc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(CCCC(O)=O)c(=O)n1Cc1ccc(C)cc1 InChI=1S/C24H27ClN4O5/c1-3-13-34-20-11-10-18(14-19(20)25)26-22-27-23(32)28(12-4-5-21(30)31)24(33)29(22)15-17-8-6-16(2)7-9-17/h6-11,14H,3-5,12-13,15H2,1-2H3,(H,30,31)(H,26,27,32) DTKKKNFHJFFXDQ-UHFFFAOYSA-N 266499 US9718790, I-0873 P2X purinoceptor 3 Homo sapiens 47.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266499 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266499&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020807 377005370 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506064 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(cc2)-c2noc(C)n2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 266500 US9718790, I-1530 P2X purinoceptor 3 Homo sapiens 93.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266500 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266500&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020268 377005371 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506066 CCOc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(CCCC(O)=O)c(=O)n1Cc1ccc(C)cc1 InChI=1S/C23H25ClN4O5/c1-3-33-19-11-10-17(13-18(19)24)25-21-26-22(31)27(12-4-5-20(29)30)23(32)28(21)14-16-8-6-15(2)7-9-16/h6-11,13H,3-5,12,14H2,1-2H3,(H,29,30)(H,25,26,31) RLSYOGUEFDIEMS-UHFFFAOYSA-N 266502 US9718790, I-0874 P2X purinoceptor 3 Homo sapiens 86.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266502 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266502&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020809 377005373 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506067 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(CC(C)(C)F)c(Cl)c2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 266503 US9718790, I-1531 P2X purinoceptor 3 Homo sapiens 25.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266503 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266503&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020870 377005374 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506068 CCn1c(=O)[nH]\c(=N/c2ccc(O[C@H]3CN[C@@H](C3)C(=O)OC)cc2)n(Cc2ccc(Cl)cc2)c1=O 266504 US9718790, I-2277 P2X purinoceptor 3 Homo sapiens 107 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266504 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266504&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945533 377005375 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506069 COC(=O)C[C@@H](C)n1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(Cl)c2)n(Cc2ccc(C)cc2)c1=O 266505 US9718790, I-0875 P2X purinoceptor 3 Homo sapiens 14.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266505 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266505&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020803 377005376 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506070 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(CC(C)(C)O)c(Cl)c2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 266506 US9718790, I-1532 P2X purinoceptor 3 Homo sapiens 25.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266506 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266506&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020881 377005377 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506071 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(nc3)C(O)=O)cc2)n(Cc2ccc(Cl)cn2)c1=O InChI=1S/C23H19ClN6O5/c1-2-29-22(33)28-21(30(23(29)34)13-16-4-3-14(24)11-25-16)27-15-5-7-17(8-6-15)35-18-9-10-19(20(31)32)26-12-18/h3-12H,2,13H2,1H3,(H,31,32)(H,27,28,33) UQFBNBJOXINBMK-UHFFFAOYSA-N 266507 US9718790, I-2278 P2X purinoceptor 3 Homo sapiens 136 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266507 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266507&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020592 377005378 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506073 COc1ccc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(CCC(O)=O)c(=O)n2Cc2ccc(Cl)cc2)cn1 InChI=1S/C25H22ClN5O6/c1-36-21-11-10-20(14-27-21)37-19-8-6-18(7-9-19)28-23-29-24(34)30(13-12-22(32)33)25(35)31(23)15-16-2-4-17(26)5-3-16/h2-11,14H,12-13,15H2,1H3,(H,32,33)(H,28,29,34) YNHGQTSOHLPJBQ-UHFFFAOYSA-N 266508 US9718790, I-1533 P2X purinoceptor 3 Homo sapiens 16.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266508 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266508&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945312 377005379 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506074 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(nc3)C(N)=O)cc2)n(Cc2ccc(Cl)cn2)c1=O InChI=1S/C23H20ClN7O4/c1-2-30-22(33)29-21(31(23(30)34)13-16-4-3-14(24)11-26-16)28-15-5-7-17(8-6-15)35-18-9-10-19(20(25)32)27-12-18/h3-12H,2,13H2,1H3,(H2,25,32)(H,28,29,33) MOCBFFLUXNROFU-UHFFFAOYSA-N 266509 US9718790, I-2279 P2X purinoceptor 3 Homo sapiens 33.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266509 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266509&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945642 377005380 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506075 CCCOc1ccc(cc1Cl)\N=c1/[nH]c(=O)n([C@H](C)CC(=O)OC)c(=O)n1Cc1ccc(C)cc1 266510 US9718790, I-0877 P2X purinoceptor 3 Homo sapiens 28.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266510 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266510&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945263 377005381 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506076 COc1ccc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n2Cc2ccc(C)cc2)cn1 266511 US9718790, I-1534 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266511 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266511&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278268 377005382 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506077 CCn1c(=O)[nH]\c(=N/c2ccc3nc(sc3c2)N2CCC2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C22H21ClN6O2S/c1-2-28-20(30)26-19(29(22(28)31)13-14-4-6-15(23)7-5-14)24-16-8-9-17-18(12-16)32-21(25-17)27-10-3-11-27/h4-9,12H,2-3,10-11,13H2,1H3,(H,24,26,30) CAMFOUUMGYNPNA-UHFFFAOYSA-N 266512 US9718790, I-2280 P2X purinoceptor 3 Homo sapiens 127 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266512 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266512&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020651 377005383 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506078 CCOc1ccc(cc1Cl)\N=c1/[nH]c(=O)n([C@H](C)CC(=O)OC)c(=O)n1Cc1ccc(C)cc1 266513 US9718790, I-0878 P2X purinoceptor 3 Homo sapiens 22.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266513 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266513&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945228 377005384 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506079 OC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(O)nc3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H20ClN5O6/c25-16-3-1-15(2-4-16)14-30-22(28-23(34)29(24(30)35)12-11-21(32)33)27-17-5-7-18(8-6-17)36-19-9-10-20(31)26-13-19/h1-10,13H,11-12,14H2,(H,26,31)(H,32,33)(H,27,28,34) HNFYRGBWMSIJCS-UHFFFAOYSA-N 266514 US9718790, I-1535 P2X purinoceptor 3 Homo sapiens 28.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266514 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266514&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020887 377005385 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506080 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cnc(nc3)C#N)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H18ClN7O3/c1-2-30-22(32)29-21(31(23(30)33)14-15-3-5-16(24)6-4-15)28-17-7-9-18(10-8-17)34-19-12-26-20(11-25)27-13-19/h3-10,12-13H,2,14H2,1H3,(H,28,29,32) CFMXPNSZIVNKKY-UHFFFAOYSA-N 266515 US9718790, I-2281 P2X purinoceptor 3 Homo sapiens 2.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266515 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266515&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945467 377005386 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506081 CCOc1ccc(cc1Cl)\N=c1/[nH]c(=O)n([C@H](C)CC(O)=O)c(=O)n1Cc1ccc(C)cc1 266516 US9718790, I-0879 P2X purinoceptor 3 Homo sapiens 58.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266516 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266516&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945213 377005387 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506082 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(O)nc3)cc2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 266517 US9718790, I-1536 P2X purinoceptor 3 Homo sapiens 24.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266517 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266517&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117756443 377005388 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506083 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cncc(n3)C(O)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H19ClN6O5/c1-2-29-22(33)28-21(30(23(29)34)13-14-3-5-15(24)6-4-14)26-16-7-9-17(10-8-16)35-19-12-25-11-18(27-19)20(31)32/h3-12H,2,13H2,1H3,(H,31,32)(H,26,28,33) QMCDJNNVTFPWKR-UHFFFAOYSA-N 266518 US9718790, I-2282 P2X purinoceptor 3 Homo sapiens <4.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266518 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266518&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278613 377005389 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506084 CCCOc1ccc(cc1Cl)\N=c1/[nH]c(=O)n([C@H](C)CC(O)=O)c(=O)n1Cc1ccc(C)cc1 266519 US9718790, I-0880 P2X purinoceptor 3 Homo sapiens 49.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266519 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266519&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945049 377005390 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506085 CCOC(=O)C1(Cn2c(=O)[nH]\c(=N/c3ccc4nc(C)sc4c3)n(Cc3ccc(Cl)cc3)c2=O)CC1 InChI=1S/C25H24ClN5O4S/c1-3-35-21(32)25(10-11-25)14-31-23(33)29-22(28-18-8-9-19-20(12-18)36-15(2)27-19)30(24(31)34)13-16-4-6-17(26)7-5-16/h4-9,12H,3,10-11,13-14H2,1-2H3,(H,28,29,33) QZFAANSQVPOKNP-UHFFFAOYSA-N 266520 US9718790, I-1537 P2X purinoceptor 3 Homo sapiens 3.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266520 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266520&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278352 377005391 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506086 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(nn3)C(N)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H20ClN7O4/c1-2-30-22(33)27-21(31(23(30)34)13-14-3-5-15(24)6-4-14)26-16-7-9-17(10-8-16)35-19-12-11-18(20(25)32)28-29-19/h3-12H,2,13H2,1H3,(H2,25,32)(H,26,27,33) IHFCQEUEVHYAAA-UHFFFAOYSA-N 266521 US9718790, I-2283 P2X purinoceptor 3 Homo sapiens <4.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266521 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266521&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278653 377005392 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506087 CO\N=C\c1ccc(cc1F)\N=c1/[nH]c(=O)n(C[C@H](C)C(=O)OC)c(=O)n1Cc1ccc(Cl)cc1 266522 US9718790, I-0881 P2X purinoceptor 3 Homo sapiens 127 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266522 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266522&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 88558812 377005393 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506088 CCOC(=O)C1(Cn2c(=O)[nH]\c(=N/c3ccc4oc(CC)c(C)c4c3)n(Cc3ccc(Cl)cc3)c2=O)CC1 InChI=1S/C28H29ClN4O5/c1-4-22-17(3)21-14-20(10-11-23(21)38-22)30-25-31-26(35)33(16-28(12-13-28)24(34)37-5-2)27(36)32(25)15-18-6-8-19(29)9-7-18/h6-11,14H,4-5,12-13,15-16H2,1-3H3,(H,30,31,35) KYUGDQINPUBSCD-UHFFFAOYSA-N 266523 US9718790, I-1538 P2X purinoceptor 3 Homo sapiens 17.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266523 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266523&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020900 377005394 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506089 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cncc(n3)C(N)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H20ClN7O4/c1-2-30-22(33)29-21(31(23(30)34)13-14-3-5-15(24)6-4-14)27-16-7-9-17(10-8-16)35-19-12-26-11-18(28-19)20(25)32/h3-12H,2,13H2,1H3,(H2,25,32)(H,27,29,33) VXQSKEXVEPILMA-UHFFFAOYSA-N 266524 US9718790, I-2284 P2X purinoceptor 3 Homo sapiens <4.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266524 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266524&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021199 377005395 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506090 CCOc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(CCC(O)=O)c(=O)n1Cc1ccc(C)cc1 InChI=1S/C22H23ClN4O5/c1-3-32-18-9-8-16(12-17(18)23)24-20-25-21(30)26(11-10-19(28)29)22(31)27(20)13-15-6-4-14(2)5-7-15/h4-9,12H,3,10-11,13H2,1-2H3,(H,28,29)(H,24,25,30) YJTFYGAJQIFEMJ-UHFFFAOYSA-N 266525 US9718790, I-0882 P2X purinoceptor 3 Homo sapiens 100.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266525 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266525&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019742 377005396 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506091 CCOC(=O)C1(Cn2c(=O)[nH]\c(=N/c3ccc4nc(CC)sc4c3)n(Cc3ccc(Cl)cc3)c2=O)CC1 InChI=1S/C26H26ClN5O4S/c1-3-21-29-19-10-9-18(13-20(19)37-21)28-23-30-24(34)32(15-26(11-12-26)22(33)36-4-2)25(35)31(23)14-16-5-7-17(27)8-6-16/h5-10,13H,3-4,11-12,14-15H2,1-2H3,(H,28,30,34) NHKNXKVXUAPWCZ-UHFFFAOYSA-N 266526 US9718790, I-1539 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266526 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266526&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278346 377005397 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506092 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cnc(nc3)C(O)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H19ClN6O5/c1-2-29-22(33)28-21(30(23(29)34)13-14-3-5-15(24)6-4-14)27-16-7-9-17(10-8-16)35-18-11-25-19(20(31)32)26-12-18/h3-12H,2,13H2,1H3,(H,31,32)(H,27,28,33) FJFAHZBFUPYNSL-UHFFFAOYSA-N 266527 US9718790, I-2285 P2X purinoceptor 3 Homo sapiens 15.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266527 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266527&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021162 377005398 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506093 CCCOc1ccc(cc1)\N=c1/[nH]c(=O)n(C[C@H](CC)C(=O)OC)c(=O)n1Cc1ccc(C)cc1 266528 US9718790, I-0883 P2X purinoceptor 3 Homo sapiens 24.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266528 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266528&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945344 377005399 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506094 CC(C)Cc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cn1 266529 US9718790, I-1540 P2X purinoceptor 3 Homo sapiens 52.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266529 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266529&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278353 377005400 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506095 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccsn3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C21H18ClN5O3S/c1-2-26-20(28)24-19(27(21(26)29)13-14-3-5-15(22)6-4-14)23-16-7-9-17(10-8-16)30-18-11-12-31-25-18/h3-12H,2,13H2,1H3,(H,23,24,28) AVPBWOGEFMTVHT-UHFFFAOYSA-N 266530 US9718790, I-2286 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266530 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266530&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278235 377005401 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506096 CC[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(C)c2)n(Cc2ccc(C)cc2)c1=O)C(=O)OC 266531 US9718790, I-0884 P2X purinoceptor 3 Homo sapiens 16.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266531 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266531&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945266 377005402 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506097 Cc1nc2ccc(cc2s1)\N=c1/[nH]c(=O)n(CC2COC(C)(C)OC2)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C25H26ClN5O4S/c1-15-27-20-9-8-19(10-21(20)36-15)28-22-29-23(32)31(12-17-13-34-25(2,3)35-14-17)24(33)30(22)11-16-4-6-18(26)7-5-16/h4-10,17H,11-14H2,1-3H3,(H,28,29,32) JGMYLVUFRJNJDK-UHFFFAOYSA-N 266532 US9718790, I-1542 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266532 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266532&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020449 377005403 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506098 CC1(C)OCC(Cn2c(=O)[nH]\c(=N/c3ccc(Oc4ccon4)cc3)n(Cc3ccc(Cl)cc3)c2=O)CO1 InChI=1S/C26H26ClN5O6/c1-26(2)35-15-18(16-36-26)14-32-24(33)29-23(31(25(32)34)13-17-3-5-19(27)6-4-17)28-20-7-9-21(10-8-20)38-22-11-12-37-30-22/h3-12,18H,13-16H2,1-2H3,(H,28,29,33) FFGNFBWPYTXBTK-UHFFFAOYSA-N 266533 US9718790, I-2287 P2X purinoceptor 3 Homo sapiens <4.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266533&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278354 377005404 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506099 CCCOc1ccc(cc1)\N=c1/[nH]c(=O)n(C[C@H](CC)C(O)=O)c(=O)n1Cc1ccc(C)cc1 266534 US9718790, I-0885 P2X purinoceptor 3 Homo sapiens 87.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266534 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266534&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945221 377005405 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506100 CNC(=O)CCn1c(=O)[nH]\c(=N/c2ccc3nc(C)sc3c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C22H21ClN6O3S/c1-13-25-17-8-7-16(11-18(17)33-13)26-20-27-21(31)28(10-9-19(30)24-2)22(32)29(20)12-14-3-5-15(23)6-4-14/h3-8,11H,9-10,12H2,1-2H3,(H,24,30)(H,26,27,31) KPADDAIIZNDJNR-UHFFFAOYSA-N 266535 US9718790, I-1543 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266535 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266535&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020451 377005406 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506101 Clc1ccc(Cn2c(=O)n(CCOC3CCCCO3)c(=O)[nH]\c2=N/c2ccc(Oc3ccon3)cc2)cc1 266536 US9718790, I-2288 P2X purinoceptor 3 Homo sapiens 1.000 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266536 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266536&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945433 377005407 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506102 CC[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(C)c2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 266537 US9718790, I-0886 P2X purinoceptor 3 Homo sapiens 76.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266537 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266537&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278165 377005408 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506103 Cc1nc2ccc(cc2s1)\N=c1/[nH]c(=O)n(CC(CO)CO)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C22H22ClN5O4S/c1-13-24-18-7-6-17(8-19(18)33-13)25-20-26-21(31)28(10-15(11-29)12-30)22(32)27(20)9-14-2-4-16(23)5-3-14/h2-8,15,29-30H,9-12H2,1H3,(H,25,26,31) XXFQNJVHACHWRD-UHFFFAOYSA-N 266538 US9718790, I-1544 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266538 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266538&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020516 377005409 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506104 CC1(C)OC[C@H](Cn2c(=O)[nH]\c(=N/c3ccc(Oc4ccon4)cc3)n(Cc3ccc(Cl)cc3)c2=O)O1 266539 US9718790, I-2289 P2X purinoceptor 3 Homo sapiens <4.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266539 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266539&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278355 377005410 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506105 CC[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O)C(=O)OC 266540 US9718790, I-0887 P2X purinoceptor 3 Homo sapiens 23.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266540 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266540&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020239 377005411 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506106 CCOC(=O)C1(Cn2c(=O)[nH]\c(=N/c3ccc4nc(C)sc4c3)n(Cc3ccc(C)cc3)c2=O)CC1 InChI=1S/C26H27N5O4S/c1-4-35-22(32)26(11-12-26)15-31-24(33)29-23(28-19-9-10-20-21(13-19)36-17(3)27-20)30(25(31)34)14-18-7-5-16(2)6-8-18/h5-10,13H,4,11-12,14-15H2,1-3H3,(H,28,29,33) UWVBKAAFSHZKRU-UHFFFAOYSA-N 266541 US9718790, I-1545 P2X purinoceptor 3 Homo sapiens 3.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266541 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266541&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020454 377005412 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506107 Cc1ccc(Cn2c(=O)n(CCC(O)=O)c(=O)[nH]\c2=N/c2c(Cl)ccc(c2C)C(F)(F)F)cc1 InChI=1S/C22H20ClF3N4O4/c1-12-3-5-14(6-4-12)11-30-19(28-20(33)29(21(30)34)10-9-17(31)32)27-18-13(2)15(22(24,25)26)7-8-16(18)23/h3-8H,9-11H2,1-2H3,(H,31,32)(H,27,28,33) RZWJIQFIYHQKHH-UHFFFAOYSA-N 266542 US9718790, I-2090 P2X purinoceptor 3 Homo sapiens <4.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266542 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266542&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019877 377005413 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506108 CCCOc1ccc(cc1)\N=c1/[nH]c(=O)n(C[C@H](CC)C(=O)OC)c(=O)n1Cc1ccc(Cl)cc1 266543 US9718790, I-0888 P2X purinoceptor 3 Homo sapiens 30.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266543 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266543&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945212 377005414 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506109 CCOC(=O)C1(Cn2c(=O)[nH]\c(=N/c3ccc4oc(CC)c(C)c4c3)n(Cc3ccc(C)cc3)c2=O)CC1 InChI=1S/C29H32N4O5/c1-5-23-19(4)22-15-21(11-12-24(22)38-23)30-26-31-27(35)33(17-29(13-14-29)25(34)37-6-2)28(36)32(26)16-20-9-7-18(3)8-10-20/h7-12,15H,5-6,13-14,16-17H2,1-4H3,(H,30,31,35) ZQVKAHDEZAYEKK-UHFFFAOYSA-N 266544 US9718790, I-1546 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266544 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266544&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020892 377005415 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506110 OCC(CO)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccon3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H22ClN5O6/c24-17-3-1-15(2-4-17)11-28-21(26-22(32)29(23(28)33)12-16(13-30)14-31)25-18-5-7-19(8-6-18)35-20-9-10-34-27-20/h1-10,16,30-31H,11-14H2,(H,25,26,32) QQMBZHUDBVMIJM-UHFFFAOYSA-N 266545 US9718790, I-2291 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266545 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266545&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278614 377005416 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506111 CC[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 266546 US9718790, I-0889 P2X purinoceptor 3 Homo sapiens 53.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266546 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266546&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020129 377005417 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506112 CCOC(=O)C1(Cn2c(=O)[nH]\c(=N/c3ccc4nc(CC)sc4c3)n(Cc3ccc(C)cc3)c2=O)CC1 InChI=1S/C27H29N5O4S/c1-4-22-29-20-11-10-19(14-21(20)37-22)28-24-30-25(34)32(16-27(12-13-27)23(33)36-5-2)26(35)31(24)15-18-8-6-17(3)7-9-18/h6-11,14H,4-5,12-13,15-16H2,1-3H3,(H,28,30,34) XNXGPDWKWMFLHH-UHFFFAOYSA-N 266547 US9718790, I-1547 P2X purinoceptor 3 Homo sapiens 3.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266547 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266547&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117756489 377005418 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506113 OCCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccon3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C21H18ClN5O5/c22-15-3-1-14(2-4-15)13-27-19(24-20(29)26(10-11-28)21(27)30)23-16-5-7-17(8-6-16)32-18-9-12-31-25-18/h1-9,12,28H,10-11,13H2,(H,23,24,29) ZVGDSCINPIKWGT-UHFFFAOYSA-N 266548 US9718790, I-2292 P2X purinoceptor 3 Homo sapiens 12.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266548 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266548&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945604 377005419 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506114 CCCOc1ccc(cc1)\N=c1/[nH]c(=O)n(C[C@H](CC)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 266549 US9718790, I-0890 P2X purinoceptor 3 Homo sapiens 32.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266549 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266549&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278166 377005420 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506115 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(OC=C)c(Cl)c2)n(Cc2ccc(C)cc2)c1=O 266550 US9718790, I-1548 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266550 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266550&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020884 377005421 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506116 OC[C@@H](O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccon3)cc2)n(Cc2ccc(Cl)cc2)c1=O 266551 US9718790, I-2293 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266551 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266551&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945535 377005422 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506117 CCCOc1ccc(cc1Cl)\N=C1/NCN(CCC(=O)OCC)C(=O)N1Cc1ccc(C)cc1 InChI=1S/C25H31ClN4O4/c1-4-14-34-22-11-10-20(15-21(22)26)28-24-27-17-29(13-12-23(31)33-5-2)25(32)30(24)16-19-8-6-18(3)7-9-19/h6-11,15H,4-5,12-14,16-17H2,1-3H3,(H,27,28) POAWODMRLAXEJG-UHFFFAOYSA-N 266552 US9718790, I-0891 P2X purinoceptor 3 Homo sapiens 13.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266552 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266552&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278469 377005423 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506118 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(OC=C)c(Cl)c2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 266553 US9718790, I-1549 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266553 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266553&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020883 377005424 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506119 OC[C@@H](O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3nccs3)cc2)n(Cc2ccc(Cl)cc2)c1=O 266554 US9718790, I-2294 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266554 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266554&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278236 377005425 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506120 COC(=O)[C@@H](C)CN1CN\C(=N/c2ccc(OC(C)C)c(C)c2)N(Cc2ccc(C=C)cc2)C1=O InChI=1S/C27H34N4O4/c1-7-21-8-10-22(11-9-21)16-31-26(28-17-30(27(31)33)15-20(5)25(32)34-6)29-23-12-13-24(19(4)14-23)35-18(2)3/h7-14,18,20H,1,15-17H2,2-6H3,(H,28,29)/t20-/m0/s1 JXVCDCLCCGSWRC-FQEVSTJZSA-N 266555 US9718790, I-0892 P2X purinoceptor 3 Homo sapiens 18.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266555 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266555&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278470 377005426 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506121 COC(=O)[C@@H](C)Cn1c(=O)nc(N(C)c2ccc(OC=C)c(Cl)c2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C25H27ClN4O5/c1-6-35-21-12-11-19(13-20(21)26)28(4)23-27-24(32)30(14-17(3)22(31)34-5)25(33)29(23)15-18-9-7-16(2)8-10-18/h6-13,17H,1,14-15H2,2-5H3/t17-/m0/s1 LNSYRFXFKPKOQJ-KRWDZBQOSA-N 266556 US9718790, I-1550 P2X purinoceptor 3 Homo sapiens 833 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266556 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266556&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 135121022 377005427 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506122 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccnc(c3)C(O)=O)c(OC)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H22ClN5O6/c1-3-30-24(34)29-23(31(25(30)35)14-15-4-6-16(26)7-5-15)28-17-8-9-20(21(12-17)36-2)37-18-10-11-27-19(13-18)22(32)33/h4-13H,3,14H2,1-2H3,(H,32,33)(H,28,29,34) ZQMBEAPXDNGHSC-UHFFFAOYSA-N 266557 US9718790, I-2295 P2X purinoceptor 3 Homo sapiens <4.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266557 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266557&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945523 377005428 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506123 CO\N=C\c1ccc(cc1F)\N=C1/NCN(C[C@H](C)C(O)=O)C(=O)N1Cc1ccc(Cl)cc1 InChI=1S/C22H23ClFN5O4/c1-14(20(30)31)11-28-13-25-21(27-18-8-5-16(10-26-33-2)19(24)9-18)29(22(28)32)12-15-3-6-17(23)7-4-15/h3-10,14H,11-13H2,1-2H3,(H,25,27)(H,30,31)/b26-10+/t14-/m0/s1 OSCKHZANALXLCL-KSUYQGFWSA-N 266558 US9718790, I-0893 P2X purinoceptor 3 Homo sapiens 202 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266558 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266558&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278167 377005429 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506124 CCc1oc2ccc(cc2c1C)\N=c1/[nH]c(=O)n(CC2(CC2)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C26H25ClN4O5/c1-3-20-15(2)19-12-18(8-9-21(19)36-20)28-23-29-24(34)31(14-26(10-11-26)22(32)33)25(35)30(23)13-16-4-6-17(27)7-5-16/h4-9,12H,3,10-11,13-14H2,1-2H3,(H,32,33)(H,28,29,34) RDLBXUOTFHNEDE-UHFFFAOYSA-N 266559 US9718790, I-1551 P2X purinoceptor 3 Homo sapiens 9.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266559 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266559&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945346 377005430 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506125 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cnc(cn3)C(O)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H19ClN6O5/c1-2-29-22(33)28-21(30(23(29)34)13-14-3-5-15(24)6-4-14)27-16-7-9-17(10-8-16)35-19-12-25-18(11-26-19)20(31)32/h3-12H,2,13H2,1H3,(H,31,32)(H,27,28,33) JVHLCFGGDWOALE-UHFFFAOYSA-N 266560 US9718790, I-2296 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266560 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266560&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020355 377005431 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506126 CCc1ccc(CN2C(=O)N(C[C@H](C)C(=O)OC)CN\C2=N/c2ccc(OC(C)C)c(C)c2)cc1 InChI=1S/C27H36N4O4/c1-7-21-8-10-22(11-9-21)16-31-26(28-17-30(27(31)33)15-20(5)25(32)34-6)29-23-12-13-24(19(4)14-23)35-18(2)3/h8-14,18,20H,7,15-17H2,1-6H3,(H,28,29)/t20-/m0/s1 DQIYDORGSSUDFW-FQEVSTJZSA-N 266561 US9718790, I-0894 P2X purinoceptor 3 Homo sapiens 28.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266561 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266561&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278288 377005432 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506127 Cc1nc2ccc(cc2s1)\N=c1/[nH]c(=O)n(CC2(CC2)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C23H20ClN5O4S/c1-13-25-17-7-6-16(10-18(17)34-13)26-20-27-21(32)29(12-23(8-9-23)19(30)31)22(33)28(20)11-14-2-4-15(24)5-3-14/h2-7,10H,8-9,11-12H2,1H3,(H,30,31)(H,26,27,32) MVVIZBCRVAURJG-UHFFFAOYSA-N 266562 US9718790, I-1552 P2X purinoceptor 3 Homo sapiens 15.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266562 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266562&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278588 377005433 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506128 CCn1c(=O)[nH]\c(=N/[C@H]2CC[C@@H](CC2)Oc2ccnc(c2)C(O)=O)n(Cc2ccc(Cl)cc2)c1=O 266563 US9718790, I-2297 P2X purinoceptor 3 Homo sapiens 65.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266563 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266563&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020233 377005434 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504401 CC(C)CNC(=O)c1ccc(Nc2nc(=O)n(C(C)C)c(=O)n2Cc2ccc(Cl)cc2)cc1 InChI=1S/C24H28ClN5O3/c1-15(2)13-26-21(31)18-7-11-20(12-8-18)27-22-28-23(32)30(16(3)4)24(33)29(22)14-17-5-9-19(25)10-6-17/h5-12,15-16H,13-14H2,1-4H3,(H,26,31)(H,27,28,32) HXHVMCCJJHMFTF-UHFFFAOYSA-N 183113 US9150546, I-256::US9688643, I-256::US9718790, I-0256 P2X purinoceptor 3 Homo sapiens 867 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183113 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183113&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821253 313634513 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504402 CC(C)Cc1ccc(cc1C)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 264852 US9718790, I-0949 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264852 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264852&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020817 377003729 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504403 CCc1oc2ccc(cc2c1C)\N=c1/[nH]c(=O)n(C[C@H]2COC(C)(C)O2)c(=O)n1Cc1ccc(Cl)cc1 264853 US9718790, I-1604 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264853 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264853&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020908 377003730 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504404 CC(C)n1c(=O)nc(Nc2ccc(cc2)C(=O)NC2CC2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H24ClN5O3/c1-14(2)29-22(31)27-21(28(23(29)32)13-15-3-7-17(24)8-4-15)26-19-9-5-16(6-10-19)20(30)25-18-11-12-18/h3-10,14,18H,11-13H2,1-2H3,(H,25,30)(H,26,27,31) KLIMXRDHTVGIJE-UHFFFAOYSA-N 183114 US9150546, I-257::US9688643, I-257::US9718790, I-0257 P2X purinoceptor 3 Homo sapiens 682 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183114 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183114&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821283 313634514 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504405 CCOC(=O)C1(Cn2c(=O)[nH]\c(=N/c3ccc(OC(C)C)c(C)c3)n(Cc3ccc(C)cc3)c2=O)CC1 InChI=1S/C28H34N4O5/c1-6-36-24(33)28(13-14-28)17-32-26(34)30-25(29-22-11-12-23(20(5)15-22)37-18(2)3)31(27(32)35)16-21-9-7-19(4)8-10-21/h7-12,15,18H,6,13-14,16-17H2,1-5H3,(H,29,30,34) YQOWBWXKKDQKRM-UHFFFAOYSA-N 264855 US9718790, I-0941 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264855 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264855&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020130 377003732 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504406 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(OC3CC3)c(Cl)c2)n(Cc2ccc(C)cc2)c1=O 264856 US9718790, I-1605 P2X purinoceptor 3 Homo sapiens 18.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264856 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264856&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020897 377003733 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504407 CC(C)n1c(=O)nc(Nc2ccc(cc2)C(=O)NCC2CC2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H26ClN5O3/c1-15(2)30-23(32)28-22(29(24(30)33)14-17-5-9-19(25)10-6-17)27-20-11-7-18(8-12-20)21(31)26-13-16-3-4-16/h5-12,15-16H,3-4,13-14H2,1-2H3,(H,26,31)(H,27,28,32) WGVHUASKTDZQAF-UHFFFAOYSA-N 183115 US9150546, I-258::US9688643, I-258::US9718790, I-0258 P2X purinoceptor 3 Homo sapiens 683 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183115 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183115&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821435 313634515 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504408 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(O[C@H](C)C(F)(F)F)cc2)n(Cc2ccc(Cl)cc2)c1=O 264858 US9718790, I-0942 P2X purinoceptor 3 Homo sapiens 22.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264858 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264858&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020086 377003735 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504409 CCOC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(OC3CC3)c(Cl)c2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C25H27ClN4O5/c1-3-34-22(31)12-13-29-24(32)28-23(30(25(29)33)15-17-6-4-16(2)5-7-17)27-18-8-11-21(20(26)14-18)35-19-9-10-19/h4-8,11,14,19H,3,9-10,12-13,15H2,1-2H3,(H,27,28,32) LEHMSZQGMNIHNB-UHFFFAOYSA-N 264859 US9718790, I-1606 P2X purinoceptor 3 Homo sapiens 15.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264859 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264859&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019808 377003736 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504410 CC(C)Cn1c2ccc(Nc3nc(=O)n(C(C)C)c(=O)n3Cc3ccc(Cl)cc3)cc2oc1=O InChI=1S/C24H26ClN5O4/c1-14(2)12-28-19-10-9-18(11-20(19)34-24(28)33)26-21-27-22(31)30(15(3)4)23(32)29(21)13-16-5-7-17(25)8-6-16/h5-11,14-15H,12-13H2,1-4H3,(H,26,27,31) LFJLSWYPCIEZFA-UHFFFAOYSA-N 264860 US9718790, I-0268 P2X purinoceptor 3 Homo sapiens 861 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264860 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264860&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821413 377003737 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504411 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(O[C@@H](C)C(F)(F)F)cc2)n(Cc2ccc(Cl)cc2)c1=O 264861 US9718790, I-0943 P2X purinoceptor 3 Homo sapiens 61.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264861 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264861&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945284 377003738 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504412 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(OC3CC3)c(Cl)c2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 264862 US9718790, I-1607 P2X purinoceptor 3 Homo sapiens 35.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264862 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264862&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020012 377003739 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504413 CC(C)Oc1ccc(Nc2nc(=O)[nH]c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C19H18ClFN4O3/c1-11(2)28-16-8-7-14(9-15(16)21)22-17-23-18(26)24-19(27)25(17)10-12-3-5-13(20)6-4-12/h3-9,11H,10H2,1-2H3,(H2,22,23,24,26,27) AJVAAPSNYAVHDF-UHFFFAOYSA-N 183117 US9150546, I-269::US9688643, I-269::US9718790, I-0269 P2X purinoceptor 3 Homo sapiens 415 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183117 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183117&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76820948 313634517 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504414 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(C)c2)n(Cc2ccc(cc2)C#C)c1=O 264864 US9718790, I-0945 P2X purinoceptor 3 Homo sapiens 173 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264864 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264864&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 88558785 377003741 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504415 Cc1ccc(Cn2c(=O)n(CCC(O)=O)c(=O)[nH]\c2=N/c2ccc(OC3CC3)c(Cl)c2)cc1 InChI=1S/C23H23ClN4O5/c1-14-2-4-15(5-3-14)13-28-21(26-22(31)27(23(28)32)11-10-20(29)30)25-16-6-9-19(18(24)12-16)33-17-7-8-17/h2-6,9,12,17H,7-8,10-11,13H2,1H3,(H,29,30)(H,25,26,31) KJHBUDKDKYKRJM-UHFFFAOYSA-N 264865 US9718790, I-1608 P2X purinoceptor 3 Homo sapiens 100.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264865 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264865&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019959 377003742 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504416 COc1cc(Cl)ccc1Cn1c(Nc2ccc(OC(C)C)c(F)c2)nc(=O)n(C(C)C)c1=O InChI=1S/C23H26ClFN4O4/c1-13(2)29-22(30)27-21(26-17-8-9-19(18(25)11-17)33-14(3)4)28(23(29)31)12-15-6-7-16(24)10-20(15)32-5/h6-11,13-14H,12H2,1-5H3,(H,26,27,30) GTFVMMIIRJHQNA-UHFFFAOYSA-N 183118 US9150546, I-270::US9688643, I-270::US9718790, I-0270 P2X purinoceptor 3 Homo sapiens 271 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183118 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183118&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821318 313634518 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504417 CC(C)Oc1ccc(cc1C)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(cc1)C#C 264867 US9718790, I-0946 P2X purinoceptor 3 Homo sapiens 239 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264867 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264867&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 88558890 377003744 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504418 CCc1oc2ccc(cc2c1C)\N=c1/[nH]c(=O)n(CC(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C23H21ClN4O5/c1-3-18-13(2)17-10-16(8-9-19(17)33-18)25-21-26-22(31)28(12-20(29)30)23(32)27(21)11-14-4-6-15(24)7-5-14/h4-10H,3,11-12H2,1-2H3,(H,29,30)(H,25,26,31) FAAUBQAIGQYELT-UHFFFAOYSA-N 264868 US9718790, I-1609 P2X purinoceptor 3 Homo sapiens 187 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264868 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264868&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019980 377003745 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504419 CC(C)Oc1ccc(Nc2nc(=O)n(CC3CC3)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C23H24ClFN4O3/c1-14(2)32-20-10-9-18(11-19(20)25)26-21-27-22(30)29(13-15-3-4-15)23(31)28(21)12-16-5-7-17(24)8-6-16/h5-11,14-15H,3-4,12-13H2,1-2H3,(H,26,27,30) KWLZBQHILCASGJ-UHFFFAOYSA-N 183119 US9150546, I-271::US9688643, I-271::US9718790, I-0271 P2X purinoceptor 3 Homo sapiens 32.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183119 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183119&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821043 313634519 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504420 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(CC(C)C)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O 264870 US9718790, I-0947 P2X purinoceptor 3 Homo sapiens 24.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264870 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264870&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020812 377003747 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504421 Cc1nc2ccc(cc2s1)\N=c1/[nH]c(=O)n(CC(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C20H16ClN5O4S/c1-11-22-15-7-6-14(8-16(15)31-11)23-18-24-19(29)26(10-17(27)28)20(30)25(18)9-12-2-4-13(21)5-3-12/h2-8H,9-10H2,1H3,(H,27,28)(H,23,24,29) SLDJRYRHMHOPMO-UHFFFAOYSA-N 264871 US9718790, I-1610 P2X purinoceptor 3 Homo sapiens 251 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264871 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264871&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020007 377003748 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504422 CC(C)Oc1ccc(Nc2nc(=O)n(CCN(C)C)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C23H27ClFN5O3/c1-15(2)33-20-10-9-18(13-19(20)25)26-21-27-22(31)29(12-11-28(3)4)23(32)30(21)14-16-5-7-17(24)8-6-16/h5-10,13,15H,11-12,14H2,1-4H3,(H,26,27,31) UCAYJQSCZMASBW-UHFFFAOYSA-N 183120 US9150546, I-272::US9688643, I-272::US9718790, I-0272 P2X purinoceptor 3 Homo sapiens 180 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183120 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183120&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821009 313634520 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504423 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(C=C(C)C)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O 264873 US9718790, I-0948 P2X purinoceptor 3 Homo sapiens 19.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264873 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264873&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020816 377003750 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504424 CC(C)Cc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(CCNC(C)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C24H27Cl2N5O3/c1-15(2)12-18-6-9-20(13-21(18)26)28-22-29-23(33)30(11-10-27-16(3)32)24(34)31(22)14-17-4-7-19(25)8-5-17/h4-9,13,15H,10-12,14H2,1-3H3,(H,27,32)(H,28,29,33) YNNFIAJQWWEVAH-UHFFFAOYSA-N 264874 US9718790, I-1611 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264874 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264874&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020126 377003751 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504425 CC(C)Oc1ccc(Nc2nc(=O)n(CCO)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C21H22ClFN4O4/c1-13(2)31-18-8-7-16(11-17(18)23)24-19-25-20(29)26(9-10-28)21(30)27(19)12-14-3-5-15(22)6-4-14/h3-8,11,13,28H,9-10,12H2,1-2H3,(H,24,25,29) XKUBPFCGXISTNR-UHFFFAOYSA-N 183121 US9150546, I-273::US9688643, I-273::US9718790, I-0273 P2X purinoceptor 3 Homo sapiens 38.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183121 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183121&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821279 313634521 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504426 CC(C)Cc1ccc(cc1C)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 264852 US9718790, I-0949 P2X purinoceptor 3 Homo sapiens 21.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264852 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264852&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020817 377003729 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504427 CCc1nc2ccc(cc2s1)\N=c1/[nH]c(=O)n(CCNC(C)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C23H23ClN6O3S/c1-3-20-27-18-9-8-17(12-19(18)34-20)26-21-28-22(32)29(11-10-25-14(2)31)23(33)30(21)13-15-4-6-16(24)7-5-15/h4-9,12H,3,10-11,13H2,1-2H3,(H,25,31)(H,26,28,32) HRDPVTPXWMDRIV-UHFFFAOYSA-N 264876 US9718790, I-1612 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264876 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264876&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020142 377003753 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504428 CC(C)Oc1ccc(Nc2nc(=O)n(CC(C)(CO)CO)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C24H28ClFN4O5/c1-15(2)35-20-9-8-18(10-19(20)26)27-21-28-22(33)30(12-24(3,13-31)14-32)23(34)29(21)11-16-4-6-17(25)7-5-16/h4-10,15,31-32H,11-14H2,1-3H3,(H,27,28,33) UTJLWFYQRDUGFC-UHFFFAOYSA-N 183122 US9150546, I-274::US9688643, I-274::US9718790, I-0274 P2X purinoceptor 3 Homo sapiens 9.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183122 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183122&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76388509 313634522 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504429 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(C=C(C)C)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 264878 US9718790, I-0950 P2X purinoceptor 3 Homo sapiens 20.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264878 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264878&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020813 377003755 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504430 CCc1nc2ccc(cc2s1)\N=c1/[nH]c(=O)n(CCCNC(C)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C24H25ClN6O3S/c1-3-21-28-19-10-9-18(13-20(19)35-21)27-22-29-23(33)30(12-4-11-26-15(2)32)24(34)31(22)14-16-5-7-17(25)8-6-16/h5-10,13H,3-4,11-12,14H2,1-2H3,(H,26,32)(H,27,29,33) MFFHVGCKKZGZNL-UHFFFAOYSA-N 264879 US9718790, I-1613 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264879 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264879&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020214 377003756 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504431 CC(C)Oc1ccc(Nc2nc(=O)n(CC3CCOCC3)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C25H28ClFN4O4/c1-16(2)35-22-8-7-20(13-21(22)27)28-23-29-24(32)31(15-18-9-11-34-12-10-18)25(33)30(23)14-17-3-5-19(26)6-4-17/h3-8,13,16,18H,9-12,14-15H2,1-2H3,(H,28,29,32) KMGNDJHSKCRYEF-UHFFFAOYSA-N 183123 US9150546, I-275::US9688643, I-275::US9718790, I-0275 P2X purinoceptor 3 Homo sapiens 21.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183123 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183123&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821452 313634523 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504432 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(c2)C#N)n(Cc2ccc(C)cc2)c1=O 264881 US9718790, I-0951 P2X purinoceptor 3 Homo sapiens 33.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264881 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264881&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945363 377003758 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504433 CC(C)Cc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(CCCNC(C)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C25H29Cl2N5O3/c1-16(2)13-19-7-10-21(14-22(19)27)29-23-30-24(34)31(12-4-11-28-17(3)33)25(35)32(23)15-18-5-8-20(26)9-6-18/h5-10,14,16H,4,11-13,15H2,1-3H3,(H,28,33)(H,29,30,34) UNSPNUPEPLCQHJ-UHFFFAOYSA-N 264882 US9718790, I-1614 P2X purinoceptor 3 Homo sapiens 9.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264882 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264882&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020307 377003759 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504434 CC(C)Oc1ccc(Nc2nc(=O)n(CC(CO)CO)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C23H26ClFN4O5/c1-14(2)34-20-8-7-18(9-19(20)25)26-21-27-22(32)29(11-16(12-30)13-31)23(33)28(21)10-15-3-5-17(24)6-4-15/h3-9,14,16,30-31H,10-13H2,1-2H3,(H,26,27,32) RUZOIAXGYPSNOT-UHFFFAOYSA-N 183124 US9150546, I-276::US9688643, I-276::US9718790, I-0276 P2X purinoceptor 3 Homo sapiens 12.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183124 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183124&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821269 313634524 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504435 CCN(C(C)C)c1ccc(cc1)\N=c1/[nH]c(=O)n(C[C@H](C)C(=O)OC)c(=O)n1Cc1ccc(Cl)cc1 264884 US9718790, I-0952 P2X purinoceptor 3 Homo sapiens 741 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264884 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264884&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020794 377003761 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504436 C[C@@H](Oc1ccc(cc1)\N=c1/[nH]c(=O)n(CCCNC(C)=O)c(=O)n1Cc1ccc(Cl)cc1)C(F)(F)F 264885 US9718790, I-1615 P2X purinoceptor 3 Homo sapiens 12.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264885 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264885&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020212 377003762 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504437 CCn1c(=O)nc(Nc2ccc(OC(C)C)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C21H22ClFN4O3/c1-4-26-20(28)25-19(24-16-9-10-18(17(23)11-16)30-13(2)3)27(21(26)29)12-14-5-7-15(22)8-6-14/h5-11,13H,4,12H2,1-3H3,(H,24,25,28) ZFOLLFDANAKBTB-UHFFFAOYSA-N 183125 US9150546, I-277::US9688643, I-277::US9718790, I-0277 P2X purinoceptor 3 Homo sapiens 38.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183125 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183125&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821275 313634525 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504438 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(c2)C#N)n(Cc2ccc(Cl)cc2)c1=O 264887 US9718790, I-0953 P2X purinoceptor 3 Homo sapiens 42.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264887 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264887&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278300 377003764 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504439 CC(C)Cc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(C[C@H](C)C(N)=O)c(=O)n1Cc1ccc(C)cc1 264888 US9718790, I-1616 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264888 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264888&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019654 377003765 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504440 OCCn1c(=O)nc(Nc2ccc(cc2)-c2ccon2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C21H18ClN5O4/c22-16-5-1-14(2-6-16)13-27-19(24-20(29)26(10-11-28)21(27)30)23-17-7-3-15(4-8-17)18-9-12-31-25-18/h1-9,12,28H,10-11,13H2,(H,23,24,29) IBYTZLXTXPKYSB-UHFFFAOYSA-N 183126 US9150546, I-278::US9688643, I-278::US9718790, I-0278 P2X purinoceptor 3 Homo sapiens 931 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183126 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183126&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821140 313634526 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504441 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(cc2)N2CCCCC2)n(Cc2ccc(Cl)cc2)c1=O 264890 US9718790, I-0954 P2X purinoceptor 3 Homo sapiens 23.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264890 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264890&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020791 377003767 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504442 C[C@@H](Oc1ccc(cc1)\N=c1/[nH]c(=O)n(CCNC(C)=O)c(=O)n1Cc1ccc(Cl)cc1)C(F)(F)F 264891 US9718790, I-1617 P2X purinoceptor 3 Homo sapiens 27.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264891 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264891&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130279112 377003768 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504443 COCCn1c(=O)nc(Nc2ccc(OC(C)C)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C22H24ClFN4O4/c1-14(2)32-19-9-8-17(12-18(19)24)25-20-26-21(29)27(10-11-31-3)22(30)28(20)13-15-4-6-16(23)7-5-15/h4-9,12,14H,10-11,13H2,1-3H3,(H,25,26,29) LFPJLMIAJIYGIU-UHFFFAOYSA-N 183127 US9150546, I-280::US9688643, I-280::US9718790, I-0280 P2X purinoceptor 3 Homo sapiens 30.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183127 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183127&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821447 313634527 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504444 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(C=C(C)C)c(Cl)c2)n(Cc2ccc(Cl)cc2)c1=O 264893 US9718790, I-0955 P2X purinoceptor 3 Homo sapiens 28.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264893 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264893&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020792 377003770 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504445 Cc1nc2ccc(cc2s1)\N=c1/[nH]c(=O)n(C[C@H](O)CO)c(=O)n1Cc1ccc(Cl)cc1 264894 US9718790, I-1618 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264894 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264894&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019675 377003771 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504446 CC(C)Oc1ccc(Nc2nc(=O)n(CCN3CCOCC3)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C25H29ClFN5O4/c1-17(2)36-22-8-7-20(15-21(22)27)28-23-29-24(33)31(10-9-30-11-13-35-14-12-30)25(34)32(23)16-18-3-5-19(26)6-4-18/h3-8,15,17H,9-14,16H2,1-2H3,(H,28,29,33) TVASFVKDNGFONS-UHFFFAOYSA-N 183128 US9150546, I-281::US9688643, I-281::US9718790, I-0281 P2X purinoceptor 3 Homo sapiens 12.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183128 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183128&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821220 313634528 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504447 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Br)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O 264896 US9718790, I-0956 P2X purinoceptor 3 Homo sapiens 139 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264896 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264896&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019651 377003773 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504448 Cc1nc2ccc(cc2s1)\N=c1/[nH]c(=O)n(CCCO)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C21H20ClN5O3S/c1-13-23-17-8-7-16(11-18(17)31-13)24-19-25-20(29)26(9-2-10-28)21(30)27(19)12-14-3-5-15(22)6-4-14/h3-8,11,28H,2,9-10,12H2,1H3,(H,24,25,29) PJJSDJVWQYPTQR-UHFFFAOYSA-N 264897 US9718790, I-1619 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264897 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264897&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945123 377003774 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504449 CC(C)Oc1ccc(Nc2nc(=O)n(CCN3CCCCC3)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C26H31ClFN5O3/c1-18(2)36-23-11-10-21(16-22(23)28)29-24-30-25(34)32(15-14-31-12-4-3-5-13-31)26(35)33(24)17-19-6-8-20(27)9-7-19/h6-11,16,18H,3-5,12-15,17H2,1-2H3,(H,29,30,34) AQIFGVPXDZVNGA-UHFFFAOYSA-N 183129 US9150546, I-282::US9688643, I-282::US9718790, I-0282 P2X purinoceptor 3 Homo sapiens 27.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183129 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183129&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821381 313634529 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504450 CCOC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(OCC3CC3)c(Cl)c2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C26H29ClN4O5/c1-3-35-23(32)12-13-30-25(33)29-24(31(26(30)34)15-18-6-4-17(2)5-7-18)28-20-10-11-22(21(27)14-20)36-16-19-8-9-19/h4-7,10-11,14,19H,3,8-9,12-13,15-16H2,1-2H3,(H,28,29,33) ONXLYISXFJWJSB-UHFFFAOYSA-N 264899 US9718790, I-0957 P2X purinoceptor 3 Homo sapiens 25.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264899 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264899&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019781 377003776 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504451 C[C@@H](Oc1ccc(cc1)\N=c1/[nH]c(=O)n(CCCO)c(=O)n1Cc1ccc(Cl)cc1)C(F)(F)F 264900 US9718790, I-1620 P2X purinoceptor 3 Homo sapiens 14.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264900 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264900&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019685 377003777 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504452 CC(C)Oc1ccc(Nc2nc(=O)n(CC(F)(F)C(O)=O)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C22H20ClF3N4O5/c1-12(2)35-17-8-7-15(9-16(17)24)27-19-28-20(33)30(11-22(25,26)18(31)32)21(34)29(19)10-13-3-5-14(23)6-4-13/h3-9,12H,10-11H2,1-2H3,(H,31,32)(H,27,28,33) IXCROGNFOOAIDL-UHFFFAOYSA-N 183130 US9150546, I-283::US9688643, I-283::US9718790, I-0283 P2X purinoceptor 3 Homo sapiens 19.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183130 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183130&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821358 313634530 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504453 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(OCC3CC3)c(Cl)c2)n(Cc2ccc(C)cc2)c1=O 264902 US9718790, I-0958 P2X purinoceptor 3 Homo sapiens 30.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264902 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264902&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019895 377003779 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504454 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccnc(O)c3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H20ClN5O4/c1-2-28-22(31)27-21(29(23(28)32)14-15-3-5-16(24)6-4-15)26-17-7-9-18(10-8-17)33-19-11-12-25-20(30)13-19/h3-13H,2,14H2,1H3,(H,25,30)(H,26,27,31) VXXVGUHUDNWHAT-UHFFFAOYSA-N 264903 US9718790, I-1621 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264903 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264903&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945589 377003780 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504455 CC(C)Oc1ccc(Nc2nc(=O)n(CC(O)=O)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C21H20ClFN4O5/c1-12(2)32-17-8-7-15(9-16(17)23)24-19-25-20(30)27(11-18(28)29)21(31)26(19)10-13-3-5-14(22)6-4-13/h3-9,12H,10-11H2,1-2H3,(H,28,29)(H,24,25,30) PLIWLWCQSVFBEL-UHFFFAOYSA-N 183131 US9150546, I-284::US9688643, I-284::US9718790, I-0284 P2X purinoceptor 3 Homo sapiens 629 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183131 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183131&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76820980 313634531 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504456 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(C=C(C)C)c(Cl)c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 264905 US9718790, I-0959 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264905 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264905&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019652 377003782 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504457 CCc1nc2ccc(cc2s1)\N=c1/[nH]c(=O)n(CCCO)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C22H22ClN5O3S/c1-2-19-25-17-9-8-16(12-18(17)32-19)24-20-26-21(30)27(10-3-11-29)22(31)28(20)13-14-4-6-15(23)7-5-14/h4-9,12,29H,2-3,10-11,13H2,1H3,(H,24,26,30) WSWKWTZBXVBJEW-UHFFFAOYSA-N 264906 US9718790, I-1622 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264906 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264906&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020008 377003783 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504458 CC(C)Oc1ccc(Nc2nc(=O)n(CCCO)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C22H24ClFN4O4/c1-14(2)32-19-9-8-17(12-18(19)24)25-20-26-21(30)27(10-3-11-29)22(31)28(20)13-15-4-6-16(23)7-5-15/h4-9,12,14,29H,3,10-11,13H2,1-2H3,(H,25,26,30) NOTRDLDWXSPKCF-UHFFFAOYSA-N 183132 US9150546, I-285::US9688643, I-285::US9718790, I-0285 P2X purinoceptor 3 Homo sapiens 14.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183132 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183132&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821080 313634532 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504459 CC(C)Oc1ccc(cc1C#N)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 264908 US9718790, I-0960 P2X purinoceptor 3 Homo sapiens 70.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264908 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264908&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945296 377003785 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504460 CC[C@@H](C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(CCCO)c(=O)n1Cc1ccc(Cl)cc1 264909 US9718790, I-1623 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264909 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264909&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019810 377003786 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504461 CC(C)Oc1ccc(Nc2nc(=O)n(C(CO)CO)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C22H24ClFN4O5/c1-13(2)33-19-8-7-16(9-18(19)24)25-20-26-21(31)28(17(11-29)12-30)22(32)27(20)10-14-3-5-15(23)6-4-14/h3-9,13,17,29-30H,10-12H2,1-2H3,(H,25,26,31) MSADNIYDADHRDA-UHFFFAOYSA-N 183133 US9150546, I-286::US9688643, I-286::US9718790, I-0286 P2X purinoceptor 3 Homo sapiens 277 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183133 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183133&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821257 313634533 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504462 CC(C)Oc1ccc(cc1C#N)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(C)cc1 264911 US9718790, I-0961 P2X purinoceptor 3 Homo sapiens 74.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264911 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264911&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278169 377003788 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504463 CCc1oc2ccc(cc2c1C)\N=c1/[nH]c(=O)n(C[C@H](O)CO)c(=O)n1Cc1ccc(Cl)cc1 264912 US9718790, I-1624 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264912 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264912&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020010 377003789 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504464 Clc1ccc(Cn2c(Nc3ccc(cc3)-c3ccon3)nc(=O)n(CCN3CCOCC3)c2=O)cc1 InChI=1S/C25H25ClN6O4/c26-20-5-1-18(2-6-20)17-32-23(27-21-7-3-19(4-8-21)22-9-14-36-29-22)28-24(33)31(25(32)34)11-10-30-12-15-35-16-13-30/h1-9,14H,10-13,15-17H2,(H,27,28,33) HZBDYVIANCHSDU-UHFFFAOYSA-N 183134 US9150546, I-287::US9688643, I-287::US9718790, I-0287 P2X purinoceptor 3 Homo sapiens 222 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183134 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183134&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821177 313634534 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504465 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(cc2)N2CCCCC2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 264914 US9718790, I-0962 P2X purinoceptor 3 Homo sapiens 31.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264914 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264914&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019835 377003791 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504466 CCc1oc2ccc(cc2c1C)\N=c1/[nH]c(=O)n(CCCO)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C24H25ClN4O4/c1-3-20-15(2)19-13-18(9-10-21(19)33-20)26-22-27-23(31)28(11-4-12-30)24(32)29(22)14-16-5-7-17(25)8-6-16/h5-10,13,30H,3-4,11-12,14H2,1-2H3,(H,26,27,31) SXWPRGIAUGKFJA-UHFFFAOYSA-N 264915 US9718790, I-1625 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264915 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264915&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020011 377003792 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504932 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n(Cc2ccccc2C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C27H24ClFN4O5/c1-16(2)38-23-12-11-20(13-22(23)29)30-25-31-26(36)33(15-18-5-3-4-6-21(18)24(34)35)27(37)32(25)14-17-7-9-19(28)10-8-17/h3-13,16H,14-15H2,1-2H3,(H,34,35)(H,30,31,36) DVUTVMVNMJUMHZ-UHFFFAOYSA-N 183290 US9150546, I-459::US9688643, I-459::US9718790, I-0468 P2X purinoceptor 3 Homo sapiens 39.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183290 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183290&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578785 313634690 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504936 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccncc3)cc2)n(Cc2ccc(C)cc2)c1=O 265382 US9718790, I-1125 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265382 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265382&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945074 377004257 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504937 CNC(=O)c1cc(Oc2ccc(cc2)\N=c2/[nH]c(=O)[nH]c(=O)n2Cc2ccc(Cl)cc2)ccn1 InChI=1S/C23H19ClN6O4/c1-25-20(31)19-12-18(10-11-26-19)34-17-8-6-16(7-9-17)27-21-28-22(32)29-23(33)30(21)13-14-2-4-15(24)5-3-14/h2-12H,13H2,1H3,(H,25,31)(H2,27,28,29,32,33) DHJQPQUTFCHZDO-UHFFFAOYSA-N 265383 US9718790, I-1846 P2X purinoceptor 3 Homo sapiens 15.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265383 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265383&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021195 377004258 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504938 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 183292 US9150546, I-461::US9688643, I-461::US9718790, I-0470 P2X purinoceptor 3 Homo sapiens 9.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183292 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183292&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578746 313634692 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504939 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cccnc3)cc2)n(Cc2ccc(C)cc2)c1=O 265385 US9718790, I-1126 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265385 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265385&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020998 377004260 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504940 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(OC)nc3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H22ClN5O4/c1-3-29-23(31)28-22(30(24(29)32)15-16-4-6-17(25)7-5-16)27-18-8-10-19(11-9-18)34-20-12-13-21(33-2)26-14-20/h4-14H,3,15H2,1-2H3,(H,27,28,31) LHJVWSJAHFDDAC-UHFFFAOYSA-N 265386 US9718790, I-1847 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265386 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265386&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021197 377004261 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504941 CCOc1ccc(cc1C)\N=c1/[nH]c(=O)n(CC(C)(C)C(=O)OC)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C25H29ClN4O5/c1-6-35-20-12-11-19(13-16(20)2)27-22-28-23(32)30(15-25(3,4)21(31)34-5)24(33)29(22)14-17-7-9-18(26)10-8-17/h7-13H,6,14-15H2,1-5H3,(H,27,28,32) JQRLNIOYJHNYAQ-UHFFFAOYSA-N 183293 US9150546, I-462::US9688643, I-462::US9718790, I-0471 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183293 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183293&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578456 313634693 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504943 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(O)nc3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H20ClN5O4/c1-2-28-22(31)27-21(29(23(28)32)14-15-3-5-16(24)6-4-15)26-17-7-9-18(10-8-17)33-19-11-12-20(30)25-13-19/h3-13H,2,14H2,1H3,(H,25,30)(H,26,27,31) ZSJWIVPNBZRTLW-UHFFFAOYSA-N 265388 US9718790, I-1848 P2X purinoceptor 3 Homo sapiens 14.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265388 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265388&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278406 377004263 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504944 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(C)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H27ClN4O4/c1-15-6-11-19(12-16(15)2)26-21-27-22(31)29(14-24(3,4)20(30)33-5)23(32)28(21)13-17-7-9-18(25)10-8-17/h6-12H,13-14H2,1-5H3,(H,26,27,31) LCTXMEPCVOFRSI-UHFFFAOYSA-N 183294 US9150546, I-463::US9688643, I-463::US9718790, I-0472 P2X purinoceptor 3 Homo sapiens 74.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183294 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183294&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578368 313634694 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504945 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(O)c2)n(Cc2ccc(C)cc2)c1=O 265390 US9718790, I-1128 P2X purinoceptor 3 Homo sapiens 21.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265390 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265390&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021048 377004265 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504946 OCC(CO)Cn1c(=O)[nH]\c(=N/c2ccc(OCC3CC3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H27ClN4O5/c25-19-5-3-16(4-6-19)11-28-22(27-23(32)29(24(28)33)12-18(13-30)14-31)26-20-7-9-21(10-8-20)34-15-17-1-2-17/h3-10,17-18,30-31H,1-2,11-15H2,(H,26,27,32) ABIWGEOKCPCZFR-UHFFFAOYSA-N 265391 US9718790, I-1849 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265391 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265391&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945259 377004266 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504947 Cc1ccc(cc1C)\N=c1/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C23H25ClN4O4/c1-14-5-10-18(11-15(14)2)25-20-26-21(31)28(13-23(3,4)19(29)30)22(32)27(20)12-16-6-8-17(24)9-7-16/h5-11H,12-13H2,1-4H3,(H,29,30)(H,25,26,31) VETDRJDGGSYGGI-UHFFFAOYSA-N 183295 US9150546, I-464::US9688643, I-464::US9718790, I-0473 P2X purinoceptor 3 Homo sapiens 564 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183295 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183295&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578487 313634695 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504948 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(OC)c2)n(Cc2ccc(C)cc2)c1=O 265393 US9718790, I-1129 P2X purinoceptor 3 Homo sapiens 11.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265393 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265393&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021057 377004268 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504949 CC(=O)OCC(CO)CCn1c(=O)[nH]\c(=N/c2ccc3nc(C)sc3c2)n(Cc2ccc(Cl)cc2)c1=O 265394 US9718790, I-1851 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265394 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265394&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945546 377004269 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504950 CCOc1ccc(cc1C)\N=c1/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C24H27ClN4O5/c1-5-34-19-11-10-18(12-15(19)2)26-21-27-22(32)29(14-24(3,4)20(30)31)23(33)28(21)13-16-6-8-17(25)9-7-16/h6-12H,5,13-14H2,1-4H3,(H,30,31)(H,26,27,32) UAGYKUJNNDRACK-UHFFFAOYSA-N 183296 US9150546, I-465::US9688643, I-465::US9718790, I-0474 P2X purinoceptor 3 Homo sapiens 57.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183296 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183296&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578552 313634696 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504951 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(OC(C)C)c2)n(Cc2ccc(C)cc2)c1=O 265396 US9718790, I-1130 P2X purinoceptor 3 Homo sapiens 133 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265396 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265396&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021009 377004271 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504952 Cc1nc2ccc(cc2s1)\N=c1/[nH]c(=O)n(CCC2COC(C)(C)OC2)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C26H28ClN5O4S/c1-16-28-21-9-8-20(12-22(21)37-16)29-23-30-24(33)31(11-10-18-14-35-26(2,3)36-15-18)25(34)32(23)13-17-4-6-19(27)7-5-17/h4-9,12,18H,10-11,13-15H2,1-3H3,(H,29,30,33) BHBMAVQRJIVNFK-UHFFFAOYSA-N 265397 US9718790, I-1852 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265397 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265397&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945571 377004272 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504953 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2cccc(Cl)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C22H22Cl2N4O4/c1-22(2,18(29)32-3)13-28-20(30)26-19(25-17-6-4-5-16(24)11-17)27(21(28)31)12-14-7-9-15(23)10-8-14/h4-11H,12-13H2,1-3H3,(H,25,26,30) BGADQIBSLMMIBV-UHFFFAOYSA-N 183297 US9150546, I-466::US9688643, I-466::US9718790, I-0475 P2X purinoceptor 3 Homo sapiens 37.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183297 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183297&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578386 313634697 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504954 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)cc2)n(Cc2ccc(C=C)cc2)c1=O 265399 US9718790, I-1131 P2X purinoceptor 3 Homo sapiens 105 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265399 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265399&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020862 377004274 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504955 Cc1nc2ccc(cc2s1)\N=c1/[nH]c(=O)n(CCC(CO)CO)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C23H24ClN5O4S/c1-14-25-19-7-6-18(10-20(19)34-14)26-21-27-22(32)28(9-8-16(12-30)13-31)23(33)29(21)11-15-2-4-17(24)5-3-15/h2-7,10,16,30-31H,8-9,11-13H2,1H3,(H,26,27,32) OEGFPRQKZIFWNV-UHFFFAOYSA-N 265400 US9718790, I-1853 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265400 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265400&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278209 377004275 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504956 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2cccc(OC(F)(F)F)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H22ClF3N4O5/c1-22(2,18(32)35-3)13-31-20(33)29-19(28-16-5-4-6-17(11-16)36-23(25,26)27)30(21(31)34)12-14-7-9-15(24)10-8-14/h4-11H,12-13H2,1-3H3,(H,28,29,33) SPZRXZLQIWQTDM-UHFFFAOYSA-N 183298 US9150546, I-467::US9688643, I-467::US9718790, I-0476 P2X purinoceptor 3 Homo sapiens 37.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183298 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183298&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578889 313634698 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506129 CCOc1ccc(cc1Cl)\N=C1/NCN(CCC(O)=O)C(=O)N1Cc1ccc(C)cc1 InChI=1S/C22H25ClN4O4/c1-3-31-19-9-8-17(12-18(19)23)25-21-24-14-26(11-10-20(28)29)22(30)27(21)13-16-6-4-15(2)5-7-16/h4-9,12H,3,10-11,13-14H2,1-2H3,(H,24,25)(H,28,29) JCVZYKFWLHJWTH-UHFFFAOYSA-N 266564 US9718790, I-0895 P2X purinoceptor 3 Homo sapiens 47.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266564 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266564&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278471 377005435 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506130 CCc1nc2ccc(cc2s1)\N=c1/[nH]c(=O)n(CC2(CC2)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C24H22ClN5O4S/c1-2-19-27-17-8-7-16(11-18(17)35-19)26-21-28-22(33)30(13-24(9-10-24)20(31)32)23(34)29(21)12-14-3-5-15(25)6-4-14/h3-8,11H,2,9-10,12-13H2,1H3,(H,31,32)(H,26,28,33) IBATUVZWNXVAJD-UHFFFAOYSA-N 266565 US9718790, I-1553 P2X purinoceptor 3 Homo sapiens 11.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266565 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266565&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945164 377005436 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506131 CC(C)Oc1ccc(cc1Cl)\N=C1/NCN(CCC(O)=O)C(=O)N1Cc1ccc(C)cc1 InChI=1S/C23H27ClN4O4/c1-15(2)32-20-9-8-18(12-19(20)24)26-22-25-14-27(11-10-21(29)30)23(31)28(22)13-17-6-4-16(3)5-7-17/h4-9,12,15H,10-11,13-14H2,1-3H3,(H,25,26)(H,29,30) GVHQWPOFLINVHQ-UHFFFAOYSA-N 266566 US9718790, I-0896 P2X purinoceptor 3 Homo sapiens 16.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266566 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266566&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278472 377005437 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506132 Cc1nc2ccc(cc2s1)\N=c1/[nH]c(=O)n(CC2(CC2)C(O)=O)c(=O)n1Cc1ccc(C)cc1 InChI=1S/C24H23N5O4S/c1-14-3-5-16(6-4-14)12-28-21(26-17-7-8-18-19(11-17)34-15(2)25-18)27-22(32)29(23(28)33)13-24(9-10-24)20(30)31/h3-8,11H,9-10,12-13H2,1-2H3,(H,30,31)(H,26,27,32) QJAZKSUTLHVGER-UHFFFAOYSA-N 266567 US9718790, I-1554 P2X purinoceptor 3 Homo sapiens 14.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266567 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266567&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945450 377005438 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506133 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cc(ccn3)C#N)cc2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C25H22N6O3/c1-3-30-24(32)29-23(31(25(30)33)16-18-6-4-17(2)5-7-18)28-20-8-10-21(11-9-20)34-22-14-19(15-26)12-13-27-22/h4-14H,3,16H2,1-2H3,(H,28,29,32) COZLGBGMAHXPDZ-UHFFFAOYSA-N 266568 US9718790, I-2300 P2X purinoceptor 3 Homo sapiens 3.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266568 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266568&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945716 377005439 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506134 CSc1n\c(=N/c2ccc(OC(C)C)cc2)n(Cc2ccc(Cl)cc2)c(=O)n1C(C)C InChI=1S/C23H27ClN4O2S/c1-15(2)28-22(31-5)26-21(25-19-10-12-20(13-11-19)30-16(3)4)27(23(28)29)14-17-6-8-18(24)9-7-17/h6-13,15-16H,14H2,1-5H3/b25-21+ XJDMLXSPEDVPPL-NJNXFGOHSA-N 266569 US9718790, I-2301 P2X purinoceptor 3 Homo sapiens 437 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266569 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266569&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 135121023 377005440 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506135 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(n3)C#N)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H19ClN6O3/c1-2-30-23(32)29-22(31(24(30)33)15-16-6-8-17(25)9-7-16)28-18-10-12-20(13-11-18)34-21-5-3-4-19(14-26)27-21/h3-13H,2,15H2,1H3,(H,28,29,32) TYPMSPVHFHGWFU-UHFFFAOYSA-N 266570 US9718790, I-2302 P2X purinoceptor 3 Homo sapiens 2.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266570 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266570&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945474 377005441 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506136 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cc(ccn3)C(O)=O)cc2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C25H23N5O5/c1-3-29-24(33)28-23(30(25(29)34)15-17-6-4-16(2)5-7-17)27-19-8-10-20(11-9-19)35-21-14-18(22(31)32)12-13-26-21/h4-14H,3,15H2,1-2H3,(H,31,32)(H,27,28,33) UYAYQLKLNVKDAK-UHFFFAOYSA-N 266571 US9718790, I-2303 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266571 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266571&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945702 377005442 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506137 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccnc(NC(=O)OC(C)(C)C)c3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C28H29ClN6O5/c1-5-34-25(36)33-24(35(27(34)38)17-18-6-8-19(29)9-7-18)31-20-10-12-21(13-11-20)39-22-14-15-30-23(16-22)32-26(37)40-28(2,3)4/h6-16H,5,17H2,1-4H3,(H,30,32,37)(H,31,33,36) KKTXKIOSNJHPLB-UHFFFAOYSA-N 266572 US9718790, I-2304 P2X purinoceptor 3 Homo sapiens 29.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266572 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266572&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021083 377005443 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506139 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(cn3)C#N)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H19ClN6O3/c1-2-30-23(32)29-22(31(24(30)33)15-16-3-6-18(25)7-4-16)28-19-8-10-20(11-9-19)34-21-12-5-17(13-26)14-27-21/h3-12,14H,2,15H2,1H3,(H,28,29,32) ZADDUFAVRKXAPP-UHFFFAOYSA-N 266574 US9718790, I-2306 P2X purinoceptor 3 Homo sapiens 2.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266574 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266574&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945726 377005445 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506140 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3nccc(n3)C(=O)OC)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H21ClN6O5/c1-3-30-23(33)29-21(31(24(30)34)14-15-4-6-16(25)7-5-15)27-17-8-10-18(11-9-17)36-22-26-13-12-19(28-22)20(32)35-2/h4-13H,3,14H2,1-2H3,(H,27,29,33) SNYWOBPTWQRXLW-UHFFFAOYSA-N 266575 US9718790, I-2307 P2X purinoceptor 3 Homo sapiens 15.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266575 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266575&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021047 377005446 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506141 COC(=O)c1cncc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(C3CC3)c(=O)n2Cc2ccc(Cl)cc2)c1 InChI=1S/C26H22ClN5O5/c1-36-23(33)17-12-22(14-28-13-17)37-21-10-6-19(7-11-21)29-24-30-25(34)32(20-8-9-20)26(35)31(24)15-16-2-4-18(27)5-3-16/h2-7,10-14,20H,8-9,15H2,1H3,(H,29,30,34) MEIJBIPIGAVYGS-UHFFFAOYSA-N 266576 US9718790, I-2308 P2X purinoceptor 3 Homo sapiens 3.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266576 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266576&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 56655625 377005447 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506142 CNC(=O)c1cc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(C3CC3)c(=O)n2Cc2ccc(Cl)cc2)ccn1 InChI=1S/C26H23ClN6O4/c1-28-23(34)22-14-21(12-13-29-22)37-20-10-6-18(7-11-20)30-24-31-25(35)33(19-8-9-19)26(36)32(24)15-16-2-4-17(27)5-3-16/h2-7,10-14,19H,8-9,15H2,1H3,(H,28,34)(H,30,31,35) QVCFNWUHRXKNPE-UHFFFAOYSA-N 266577 US9718790, I-2309 P2X purinoceptor 3 Homo sapiens 2.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266577 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266577&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945596 377005448 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506143 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccnc(n3)C#N)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H18ClN7O3/c1-2-30-22(32)29-21(31(23(30)33)14-15-3-5-16(24)6-4-15)27-17-7-9-18(10-8-17)34-20-11-12-26-19(13-25)28-20/h3-12H,2,14H2,1H3,(H,27,29,32) XNRLZHISNSWYRE-UHFFFAOYSA-N 266578 US9718790, I-2310 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266578 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266578&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 56655699 377005449 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506144 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3nccc(n3)C(N)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H20ClN7O4/c1-2-30-22(33)29-20(31(23(30)34)13-14-3-5-15(24)6-4-14)27-16-7-9-17(10-8-16)35-21-26-12-11-18(28-21)19(25)32/h3-12H,2,13H2,1H3,(H2,25,32)(H,27,29,33) GVOHHDMEYOAHKV-UHFFFAOYSA-N 266579 US9718790, I-2311 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266579 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266579&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945542 377005450 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506145 CCc1cc2cc(ccc2o1)\N=c1/[nH]c(=O)n(CC2COC(C)(C)OC2)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C27H29ClN4O5/c1-4-22-12-19-11-21(9-10-23(19)37-22)29-24-30-25(33)32(14-18-15-35-27(2,3)36-16-18)26(34)31(24)13-17-5-7-20(28)8-6-17/h5-12,18H,4,13-16H2,1-3H3,(H,29,30,33) REQQOGKUTCXWTE-UHFFFAOYSA-N 266580 US9718790, I-2312 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266580 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266580&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278397 377005451 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506146 CCc1cc2cc(ccc2o1)\N=c1/[nH]c(=O)n(CC(CO)CO)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C24H25ClN4O5/c1-2-20-10-17-9-19(7-8-21(17)34-20)26-22-27-23(32)29(12-16(13-30)14-31)24(33)28(22)11-15-3-5-18(25)6-4-15/h3-10,16,30-31H,2,11-14H2,1H3,(H,26,27,32) YEIPLDVZOLVPNM-UHFFFAOYSA-N 266581 US9718790, I-2313 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266581 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266581&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021089 377005452 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506147 CCc1cc2cc(ccc2o1)\N=c1/[nH]c(=O)n(C[C@H]2COC(C)(C)O2)c(=O)n1Cc1ccc(Cl)cc1 266582 US9718790, I-2314 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266582 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266582&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278623 377005453 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506148 CCc1cc2cc(ccc2o1)\N=c1/[nH]c(=O)n(C[C@H](O)CO)c(=O)n1Cc1ccc(Cl)cc1 266583 US9718790, I-2315 P2X purinoceptor 3 Homo sapiens 17.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266583 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266583&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278624 377005454 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506149 CNCCCn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H27ClFN5O3/c1-15(2)33-20-10-9-18(13-19(20)25)27-21-28-22(31)29(12-4-11-26-3)23(32)30(21)14-16-5-7-17(24)8-6-16/h5-10,13,15,26H,4,11-12,14H2,1-3H3,(H,27,28,31) UJPRCIUUSGKMIR-UHFFFAOYSA-N 266584 US9718790, I-2316 P2X purinoceptor 3 Homo sapiens 51.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266584 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266584&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 56655768 377005455 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506150 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n(CCCN(C)C(C)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C25H29ClFN5O4/c1-16(2)36-22-11-10-20(14-21(22)27)28-23-29-24(34)31(13-5-12-30(4)17(3)33)25(35)32(23)15-18-6-8-19(26)9-7-18/h6-11,14,16H,5,12-13,15H2,1-4H3,(H,28,29,34) YKKHSVUFWNFEJT-UHFFFAOYSA-N 266585 US9718790, I-2317 P2X purinoceptor 3 Homo sapiens 3.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266585 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266585&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 56655769 377005456 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506151 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cncc(c3)C#N)cc2)n(Cc2ccc(Cl)cn2)c1=O InChI=1S/C23H18ClN7O3/c1-2-30-22(32)29-21(31(23(30)33)14-18-4-3-16(24)12-27-18)28-17-5-7-19(8-6-17)34-20-9-15(10-25)11-26-13-20/h3-9,11-13H,2,14H2,1H3,(H,28,29,32) ATJKUHHHIMUCKK-UHFFFAOYSA-N 266586 US9718790, I-2318 P2X purinoceptor 3 Homo sapiens 18.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266586 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266586&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945486 377005457 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506152 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3nccc(n3)C(O)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H19ClN6O5/c1-2-29-22(33)28-20(30(23(29)34)13-14-3-5-15(24)6-4-14)26-16-7-9-17(10-8-16)35-21-25-12-11-18(27-21)19(31)32/h3-12H,2,13H2,1H3,(H,31,32)(H,26,28,33) NNXNXTCMMZSANQ-UHFFFAOYSA-N 266587 US9718790, I-2319 P2X purinoceptor 3 Homo sapiens 17.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266587 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266587&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 56655771 377005458 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506153 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(cn3)C(O)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H20ClN5O5/c1-2-29-23(33)28-22(30(24(29)34)14-15-3-6-17(25)7-4-15)27-18-8-10-19(11-9-18)35-20-12-5-16(13-26-20)21(31)32/h3-13H,2,14H2,1H3,(H,31,32)(H,27,28,33) MSKDCGIFWJWBHZ-UHFFFAOYSA-N 266588 US9718790, I-2320 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266588 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266588&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 56655844 377005459 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506154 CCn1c(=O)[nH]\c(=N/c2ccc3nc(Cl)sc3c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C19H15Cl2N5O2S/c1-2-25-18(27)24-17(22-13-7-8-14-15(9-13)29-16(21)23-14)26(19(25)28)10-11-3-5-12(20)6-4-11/h3-9H,2,10H2,1H3,(H,22,24,27) AZXDUHSWOYZFIB-UHFFFAOYSA-N 266589 US9718790, I-2321 P2X purinoceptor 3 Homo sapiens 11.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266589 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266589&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 56655845 377005460 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506155 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ncc(cn3)C(=O)OC)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H21ClN6O5/c1-3-30-23(33)29-21(31(24(30)34)14-15-4-6-17(25)7-5-15)28-18-8-10-19(11-9-18)36-22-26-12-16(13-27-22)20(32)35-2/h4-13H,3,14H2,1-2H3,(H,28,29,33) FDJXUEVHSZQESV-UHFFFAOYSA-N 266590 US9718790, I-2322 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266590 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266590&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 56655843 377005461 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506156 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ncc(cn3)C(O)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H19ClN6O5/c1-2-29-22(33)28-20(30(23(29)34)13-14-3-5-16(24)6-4-14)27-17-7-9-18(10-8-17)35-21-25-11-15(12-26-21)19(31)32/h3-12H,2,13H2,1H3,(H,31,32)(H,27,28,33) SUMZJCFJATXVOY-UHFFFAOYSA-N 266591 US9718790, I-2323 P2X purinoceptor 3 Homo sapiens 16.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266591 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266591&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 56655772 377005462 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506157 CCn1c(=O)[nH]\c(=N/c2ccc3nc(OCC(=O)OC)sc3c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C22H20ClN5O5S/c1-3-27-20(30)26-19(28(22(27)31)11-13-4-6-14(23)7-5-13)24-15-8-9-16-17(10-15)34-21(25-16)33-12-18(29)32-2/h4-10H,3,11-12H2,1-2H3,(H,24,26,30) LYYWGYJCMVIKKI-UHFFFAOYSA-N 266592 US9718790, I-2324 P2X purinoceptor 3 Homo sapiens 115 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266592 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266592&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945723 377005463 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506158 CCn1c(=O)[nH]\c(=N/c2ccc3nc(O)sc3c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C19H16ClN5O3S/c1-2-24-17(26)23-16(21-13-7-8-14-15(9-13)29-18(27)22-14)25(19(24)28)10-11-3-5-12(20)6-4-11/h3-9H,2,10H2,1H3,(H,22,27)(H,21,23,26) PEUGRKJWFRIODB-UHFFFAOYSA-N 266593 US9718790, I-2325 P2X purinoceptor 3 Homo sapiens 47.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266593 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266593&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020606 377005464 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506159 CCn1c(=O)[nH]\c(=N/c2ccc3nc(OCC(O)=O)sc3c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C21H18ClN5O5S/c1-2-26-19(30)25-18(27(21(26)31)10-12-3-5-13(22)6-4-12)23-14-7-8-15-16(9-14)33-20(24-15)32-11-17(28)29/h3-9H,2,10-11H2,1H3,(H,28,29)(H,23,25,30) JLRFVJVKOSXARP-UHFFFAOYSA-N 266594 US9718790, I-2326 P2X purinoceptor 3 Homo sapiens 108 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266594 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266594&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020607 377005465 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506160 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(\C=C\C(=O)OC)c3)cc2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C29H28N4O5/c1-4-32-28(35)31-27(33(29(32)36)19-22-10-8-20(2)9-11-22)30-23-13-15-24(16-14-23)38-25-7-5-6-21(18-25)12-17-26(34)37-3/h5-18H,4,19H2,1-3H3,(H,30,31,35)/b17-12+ KPTJZGQUSGYZCJ-SFQUDFHCSA-N 266595 US9718790, I-2327 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266595 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266595&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020586 377005466 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506161 COC(=O)\C=C\c1cccc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(C)c(=O)n2Cc2ccc(C)cc2)c1 InChI=1S/C28H26N4O5/c1-19-7-9-21(10-8-19)18-32-26(30-27(34)31(2)28(32)35)29-22-12-14-23(15-13-22)37-24-6-4-5-20(17-24)11-16-25(33)36-3/h4-17H,18H2,1-3H3,(H,29,30,34)/b16-11+ UDWZMKAEEGHFBU-LFIBNONCSA-N 266596 US9718790, I-2328 P2X purinoceptor 3 Homo sapiens 34.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266596 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266596&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019733 377005467 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506162 COC(=O)\C=C\c1cccc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(C)c(=O)n2Cc2ccc(Cl)cc2)c1 InChI=1S/C27H23ClN4O5/c1-31-26(34)30-25(32(27(31)35)17-19-6-9-20(28)10-7-19)29-21-11-13-22(14-12-21)37-23-5-3-4-18(16-23)8-15-24(33)36-2/h3-16H,17H2,1-2H3,(H,29,30,34)/b15-8+ XIBYYLLQVLIOFU-OVCLIPMQSA-N 266597 US9718790, I-2329 P2X purinoceptor 3 Homo sapiens 70.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266597 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266597&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019874 377005468 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506163 OC(=O)c1cc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(C3CC3)c(=O)n2Cc2ccc(Cl)cc2)ccn1 InChI=1S/C25H20ClN5O5/c26-16-3-1-15(2-4-16)14-30-23(29-24(34)31(25(30)35)18-7-8-18)28-17-5-9-19(10-6-17)36-20-11-12-27-21(13-20)22(32)33/h1-6,9-13,18H,7-8,14H2,(H,32,33)(H,28,29,34) SILLBAJGOGEIGD-UHFFFAOYSA-N 266598 US9718790, I-2330 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266598 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266598&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019875 377005469 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506164 OC(=O)c1cncc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(C3CC3)c(=O)n2Cc2ccc(Cl)cc2)c1 InChI=1S/C25H20ClN5O5/c26-17-3-1-15(2-4-17)14-30-23(29-24(34)31(25(30)35)19-7-8-19)28-18-5-9-20(10-6-18)36-21-11-16(22(32)33)12-27-13-21/h1-6,9-13,19H,7-8,14H2,(H,32,33)(H,28,29,34) ARBQZXFYXCHNHR-UHFFFAOYSA-N 266599 US9718790, I-2331 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266599 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266599&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019865 377005470 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506165 COC(=O)c1cncc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(C3COC3)c(=O)n2Cc2ccc(Cl)cc2)c1 InChI=1S/C26H22ClN5O6/c1-36-23(33)17-10-22(12-28-11-17)38-21-8-6-19(7-9-21)29-24-30-25(34)32(20-14-37-15-20)26(35)31(24)13-16-2-4-18(27)5-3-16/h2-12,20H,13-15H2,1H3,(H,29,30,34) GDZDNOZJSUXNLX-UHFFFAOYSA-N 266600 US9718790, I-2332 P2X purinoceptor 3 Homo sapiens 218 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266600 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266600&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278399 377005471 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506166 CC1(C)OC[C@H](Cn2c(=O)[nH]\c(=N/c3ccc(Oc4cncc(F)c4)cc3)n(Cc3ccc(Cl)cc3)c2=O)O1 266601 US9718790, I-2333 P2X purinoceptor 3 Homo sapiens 3.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266601 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266601&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019792 377005472 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506167 OC[C@@H](O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cncc(F)c3)cc2)n(Cc2ccc(Cl)cc2)c1=O 266602 US9718790, I-2334 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266602 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266602&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278657 377005473 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506168 CCc1cc2cc(ccc2o1)\N=c1/[nH]c(=O)n(CCCOC2CCCCO2)c(=O)n1Cc1ccc(Cl)cc1 266603 US9718790, I-2335 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266603 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266603&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278433 377005474 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506169 CCc1cc2cc(ccc2o1)\N=c1/[nH]c(=O)n(CCCO)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C23H23ClN4O4/c1-2-19-13-16-12-18(8-9-20(16)32-19)25-21-26-22(30)27(10-3-11-29)23(31)28(21)14-15-4-6-17(24)7-5-15/h4-9,12-13,29H,2-3,10-11,14H2,1H3,(H,25,26,30) FOUYQHAUZLEUML-UHFFFAOYSA-N 266604 US9718790, I-2336 P2X purinoceptor 3 Homo sapiens 10.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266604 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266604&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019969 377005475 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506170 CCn1c(=O)[nH]\c(=N/c2ccc3nc(\C=N/OC)sc3c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C21H19ClN6O3S/c1-3-27-20(29)26-19(28(21(27)30)12-13-4-6-14(22)7-5-13)24-15-8-9-16-17(10-15)32-18(25-16)11-23-31-2/h4-11H,3,12H2,1-2H3,(H,24,26,29)/b23-11- HGRUECQYABVTNK-KSEXSDGBSA-N 266605 US9718790, I-2338 P2X purinoceptor 3 Homo sapiens 260 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266605 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266605&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 88558774 377005476 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506172 Cc1ccc(Cn2c(=O)n(C)c(=O)[nH]\c2=N/c2ccc(Oc3cc(ccn3)C#N)cc2)cc1 InChI=1S/C24H20N6O3/c1-16-3-5-17(6-4-16)15-30-22(28-23(31)29(2)24(30)32)27-19-7-9-20(10-8-19)33-21-13-18(14-25)11-12-26-21/h3-13H,15H2,1-2H3,(H,27,28,31) BVNBCOSYJYIGRC-UHFFFAOYSA-N 266606 US9718790, I-2340 P2X purinoceptor 3 Homo sapiens 13.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266606 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266606&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945459 377005477 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506173 Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cc(ccn3)C#N)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H17ClN6O3/c1-29-22(31)28-21(30(23(29)32)14-15-2-4-17(24)5-3-15)27-18-6-8-19(9-7-18)33-20-12-16(13-25)10-11-26-20/h2-12H,14H2,1H3,(H,27,28,31) ZQJYTNKIBWGJQI-UHFFFAOYSA-N 266607 US9718790, I-2341 P2X purinoceptor 3 Homo sapiens 10.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266607 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266607&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278400 377005478 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506174 Cc1ccc(Cn2c(=O)n(C)c(=O)[nH]\c2=N/c2ccc(Oc3cc(ccn3)C(N)=O)cc2)cc1 InChI=1S/C24H22N6O4/c1-15-3-5-16(6-4-15)14-30-22(28-23(32)29(2)24(30)33)27-18-7-9-19(10-8-18)34-20-13-17(21(25)31)11-12-26-20/h3-13H,14H2,1-2H3,(H2,25,31)(H,27,28,32) XZXQTFYOWCPDHK-UHFFFAOYSA-N 266608 US9718790, I-2342 P2X purinoceptor 3 Homo sapiens 16.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266608 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266608&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020045 377005479 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506175 Cc1ccc(Cn2c(=O)n(C)c(=O)[nH]\c2=N/c2ccc(Oc3cc(ccn3)C(O)=O)cc2)cc1 InChI=1S/C24H21N5O5/c1-15-3-5-16(6-4-15)14-29-22(27-23(32)28(2)24(29)33)26-18-7-9-19(10-8-18)34-20-13-17(21(30)31)11-12-25-20/h3-13H,14H2,1-2H3,(H,30,31)(H,26,27,32) DAHUQLQUAWMHGO-UHFFFAOYSA-N 266609 US9718790, I-2343 P2X purinoceptor 3 Homo sapiens 19.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266609 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266609&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020047 377005480 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506176 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(\C=C\C(O)=O)c3)cc2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C28H26N4O5/c1-3-31-27(35)30-26(32(28(31)36)18-21-9-7-19(2)8-10-21)29-22-12-14-23(15-13-22)37-24-6-4-5-20(17-24)11-16-25(33)34/h4-17H,3,18H2,1-2H3,(H,33,34)(H,29,30,35)/b16-11+ ZHNSYDHZEQXNKZ-LFIBNONCSA-N 266610 US9718790, I-2344 P2X purinoceptor 3 Homo sapiens 3.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266610 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266610&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278625 377005481 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506177 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ncccc3C#N)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H19ClN6O3/c1-2-30-23(32)29-22(31(24(30)33)15-16-5-7-18(25)8-6-16)28-19-9-11-20(12-10-19)34-21-17(14-26)4-3-13-27-21/h3-13H,2,15H2,1H3,(H,28,29,32) BGZJDZBTPZABDP-UHFFFAOYSA-N 266611 US9718790, I-2345 P2X purinoceptor 3 Homo sapiens 20.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266611 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266611&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278626 377005482 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506178 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3nc(C)c(s3)C(O)=O)cc2)n(C[C@H]2CC[C@H](C)CC2)c1=O 266612 US9718790, I-2346 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266612 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266612&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945692 377005483 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506179 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ncc(s3)C(O)=O)cc2)n(C[C@H]2CC[C@H](C)CC2)c1=O 266613 US9718790, I-2347 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266613 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266613&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945513 377005484 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506180 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3nc(cs3)C(O)=O)cc2)n(C[C@H]2CC[C@H](C)CC2)c1=O 266614 US9718790, I-2348 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266614 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266614&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278401 377005485 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506181 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cc(sn3)C(O)=O)cc2)n(C[C@H]2CC[C@H](C)CC2)c1=O 266615 US9718790, I-2349 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266615 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266615&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945552 377005486 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506182 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccsn3)cc2)n(C[C@H]2CC[C@H](C)CC2)c1=O 266616 US9718790, I-2350 P2X purinoceptor 3 Homo sapiens 2.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266616 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266616&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020084 377005487 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506183 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(nc3)C(O)=O)cc2)n(C[C@H]2CC[C@H](C)CC2)c1=O 266617 US9718790, I-2351 P2X purinoceptor 3 Homo sapiens 9.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266617 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266617&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945646 377005488 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506184 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cncc(c3)C(O)=O)cc2)n(C[C@H]2CC[C@H](C)CC2)c1=O 266618 US9718790, I-2352 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266618 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266618&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945443 377005489 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506185 Cc1cc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(CC(CO)CO)c(=O)n2Cc2ccc(Cl)cc2)no1 InChI=1S/C24H24ClN5O6/c1-15-10-21(28-36-15)35-20-8-6-19(7-9-20)26-22-27-23(33)30(12-17(13-31)14-32)24(34)29(22)11-16-2-4-18(25)5-3-16/h2-10,17,31-32H,11-14H2,1H3,(H,26,27,33) FBUCOWLSBLJOJJ-UHFFFAOYSA-N 266619 US9718790, I-2353 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266619 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266619&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945685 377005490 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506186 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(c3)C(O)=O)cc2)n(C[C@H]2CC[C@H](C)CC2)c1=O 266620 US9718790, I-2354 P2X purinoceptor 3 Homo sapiens 3.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266620 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266620&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278356 377005491 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506187 Cc1nnc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(C)c(=O)n2Cc2ccc(Cl)cc2)o1 InChI=1S/C20H17ClN6O4/c1-12-24-25-19(30-12)31-16-9-7-15(8-10-16)22-17-23-18(28)26(2)20(29)27(17)11-13-3-5-14(21)6-4-13/h3-10H,11H2,1-2H3,(H,22,23,28) RMWWUZHCAKLUSK-UHFFFAOYSA-N 266621 US9718790, I-2355 P2X purinoceptor 3 Homo sapiens 71.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266621 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266621&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278435 377005492 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506188 Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccon3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C20H16ClN5O4/c1-25-19(27)23-18(26(20(25)28)12-13-2-4-14(21)5-3-13)22-15-6-8-16(9-7-15)30-17-10-11-29-24-17/h2-11H,12H2,1H3,(H,22,23,27) WHGWDODMQODBFD-UHFFFAOYSA-N 266622 US9718790, I-2356 P2X purinoceptor 3 Homo sapiens 24.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266622 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266622&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019861 377005493 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506189 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccon3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C21H18ClN5O4/c1-2-26-20(28)24-19(27(21(26)29)13-14-3-5-15(22)6-4-14)23-16-7-9-17(10-8-16)31-18-11-12-30-25-18/h3-12H,2,13H2,1H3,(H,23,24,28) BEIWLQDBQPYNHC-UHFFFAOYSA-N 266623 US9718790, I-2357 P2X purinoceptor 3 Homo sapiens 12.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266623 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266623&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020057 377005494 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506190 OCCCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccon3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C22H20ClN5O5/c23-16-4-2-15(3-5-16)14-28-20(25-21(30)27(22(28)31)11-1-12-29)24-17-6-8-18(9-7-17)33-19-10-13-32-26-19/h2-10,13,29H,1,11-12,14H2,(H,24,25,30) CHOIQIFRKFKALO-UHFFFAOYSA-N 266624 US9718790, I-2358 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266624 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266624&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019862 377005495 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506191 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccnc(c3)C(=O)OC)cc2)n(Cc2ccc(F)cc2)c1=O InChI=1S/C25H22FN5O5/c1-3-30-24(33)29-23(31(25(30)34)15-16-4-6-17(26)7-5-16)28-18-8-10-19(11-9-18)36-20-12-13-27-21(14-20)22(32)35-2/h4-14H,3,15H2,1-2H3,(H,28,29,33) MFKNTNIQOWARKU-UHFFFAOYSA-N 266625 US9718790, I-2359 P2X purinoceptor 3 Homo sapiens 26.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266625 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266625&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020037 377005496 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506192 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccnc(c3)C(O)=O)cc2)n(Cc2ccc(F)cc2)c1=O InChI=1S/C24H20FN5O5/c1-2-29-23(33)28-22(30(24(29)34)14-15-3-5-16(25)6-4-15)27-17-7-9-18(10-8-17)35-19-11-12-26-20(13-19)21(31)32/h3-13H,2,14H2,1H3,(H,31,32)(H,27,28,33) CFSQQVCQKKUFEI-UHFFFAOYSA-N 266626 US9718790, I-2360 P2X purinoceptor 3 Homo sapiens 11.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266626 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266626&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278357 377005497 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506193 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccnc(c3)C(N)=O)cc2)n(Cc2ccc(F)cc2)c1=O InChI=1S/C24H21FN6O4/c1-2-30-23(33)29-22(31(24(30)34)14-15-3-5-16(25)6-4-15)28-17-7-9-18(10-8-17)35-19-11-12-27-20(13-19)21(26)32/h3-13H,2,14H2,1H3,(H2,26,32)(H,28,29,33) BHXZTURRNHPAGY-UHFFFAOYSA-N 266627 US9718790, I-2361 P2X purinoceptor 3 Homo sapiens 15.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266627 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266627&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 89640244 377005498 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506194 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ncccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C22H19ClN6O3/c1-2-28-21(30)27-19(29(22(28)31)14-15-4-6-16(23)7-5-15)26-17-8-10-18(11-9-17)32-20-24-12-3-13-25-20/h3-13H,2,14H2,1H3,(H,26,27,30) VGLBDFHKVGESED-UHFFFAOYSA-N 266628 US9718790, I-2362 P2X purinoceptor 3 Homo sapiens 10.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266628 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266628&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278627 377005499 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506195 Cc1ccc(Cn2c(=O)n(C)c(=O)[nH]\c2=N/c2ccc(Oc3cccc(\C=C\C(O)=O)c3)cc2)cc1 InChI=1S/C27H24N4O5/c1-18-6-8-20(9-7-18)17-31-25(29-26(34)30(2)27(31)35)28-21-11-13-22(14-12-21)36-23-5-3-4-19(16-23)10-15-24(32)33/h3-16H,17H2,1-2H3,(H,32,33)(H,28,29,34)/b15-10+ BMURCEGASARAKZ-XNTDXEJSSA-N 266629 US9718790, I-2363 P2X purinoceptor 3 Homo sapiens 9.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266629 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266629&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278402 377005500 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506196 Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(\C=C\C(O)=O)c3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H21ClN4O5/c1-30-25(34)29-24(31(26(30)35)16-18-5-8-19(27)9-6-18)28-20-10-12-21(13-11-20)36-22-4-2-3-17(15-22)7-14-23(32)33/h2-15H,16H2,1H3,(H,32,33)(H,28,29,34)/b14-7+ APKGYIARRAMSGJ-VGOFMYFVSA-N 266630 US9718790, I-2364 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266630 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266630&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021155 377005501 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504467 CC(C)Oc1ccc(Nc2nc(=O)n(CC#N)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C21H19ClFN5O3/c1-13(2)31-18-8-7-16(11-17(18)23)25-19-26-20(29)27(10-9-24)21(30)28(19)12-14-3-5-15(22)6-4-14/h3-8,11,13H,10,12H2,1-2H3,(H,25,26,29) SHZBDZQJVOICIK-UHFFFAOYSA-N 183135 US9150546, I-288::US9688643, I-288::US9718790, I-0288 P2X purinoceptor 3 Homo sapiens 93.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183135 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183135&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821284 313634535 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504468 CCN(C(C)C)c1ccc(cc1)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 264917 US9718790, I-0963 P2X purinoceptor 3 Homo sapiens 662 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264917 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264917&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019913 377003794 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504469 CC[C@@H](C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cn1 264918 US9718790, I-1626 P2X purinoceptor 3 Homo sapiens 18.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264918 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264918&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020922 377003795 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504470 CC(C)Oc1ccc(Nc2nc(=O)n(CCC(O)=O)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C22H22ClFN4O5/c1-13(2)33-18-8-7-16(11-17(18)24)25-20-26-21(31)27(10-9-19(29)30)22(32)28(20)12-14-3-5-15(23)6-4-14/h3-8,11,13H,9-10,12H2,1-2H3,(H,29,30)(H,25,26,31) MCTZNTUJEJXMFG-UHFFFAOYSA-N 183136 US9150546, I-289::US9688643, I-289::US9718790, I-0289 P2X purinoceptor 3 Homo sapiens 66.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183136 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183136&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821389 313634536 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504471 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Br)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 264920 US9718790, I-0964 P2X purinoceptor 3 Homo sapiens 344 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264920 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264920&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019902 377003797 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504472 CCOC(=O)CCCn1c(=O)[nH]\c(=N/c2ccc3oc(CC)c(C)c3c2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C28H32N4O5/c1-5-23-19(4)22-16-21(13-14-24(22)37-23)29-26-30-27(34)31(15-7-8-25(33)36-6-2)28(35)32(26)17-20-11-9-18(3)10-12-20/h9-14,16H,5-8,15,17H2,1-4H3,(H,29,30,34) OUZOHWQRRQFMNB-UHFFFAOYSA-N 264921 US9718790, I-1627 P2X purinoceptor 3 Homo sapiens 9.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264921 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264921&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020930 377003798 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504473 CC(C)Oc1ccc(Nc2nc(=O)n(CCN)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C21H23ClFN5O3/c1-13(2)31-18-8-7-16(11-17(18)23)25-19-26-20(29)27(10-9-24)21(30)28(19)12-14-3-5-15(22)6-4-14/h3-8,11,13H,9-10,12,24H2,1-2H3,(H,25,26,29) SAZRRLWYPWSLHE-UHFFFAOYSA-N 183137 US9150546, I-290::US9688643, I-290::US9718790, I-0290 P2X purinoceptor 3 Homo sapiens 266 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183137 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183137&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821151 313634537 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504474 COC(=O)[C@H](C)[C@H](C)n1c(=O)[nH]\c(=N/c2ccc(OCC3CC3)cc2)n(Cc2ccc(C)cc2)c1=O 264923 US9718790, I-0965 P2X purinoceptor 3 Homo sapiens 21.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264923 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264923&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945243 377003799 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504475 OC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(OCc3ccccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H22ClN5O5/c26-18-6-4-17(5-7-18)15-31-23(29-24(34)30(25(31)35)14-12-22(32)33)28-19-8-10-21(11-9-19)36-16-20-3-1-2-13-27-20/h1-11,13H,12,14-16H2,(H,32,33)(H,28,29,34) QGMQMQSUTOEVQV-UHFFFAOYSA-N 264924 US9718790, I-1628 P2X purinoceptor 3 Homo sapiens 683 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264924 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264924&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020923 377003800 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504476 CC(C)Oc1ccc(Nc2nc(=O)n(CCC#N)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C22H21ClFN5O3/c1-14(2)32-19-9-8-17(12-18(19)24)26-20-27-21(30)28(11-3-10-25)22(31)29(20)13-15-4-6-16(23)7-5-15/h4-9,12,14H,3,11,13H2,1-2H3,(H,26,27,30) MUAVUCGFIWKKLX-UHFFFAOYSA-N 183138 US9150546, I-291::US9688643, I-291::US9718790, I-0291 P2X purinoceptor 3 Homo sapiens 9.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183138 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183138&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821316 313634538 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504477 CCOc1ccc(cc1Cl)\N=c1/[nH]c(=O)n([C@@H](C)[C@@H](C)C(=O)OC)c(=O)n1Cc1ccc(C)cc1 264926 US9718790, I-0966 P2X purinoceptor 3 Homo sapiens 17.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264926 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264926&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019559 377003802 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504478 CCOC(=O)CCCn1c(=O)[nH]\c(=N/c2ccc3nc(CC)sc3c2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C26H29N5O4S/c1-4-22-28-20-13-12-19(15-21(20)36-22)27-24-29-25(33)30(14-6-7-23(32)35-5-2)26(34)31(24)16-18-10-8-17(3)9-11-18/h8-13,15H,4-7,14,16H2,1-3H3,(H,27,29,33) BTSYNFBYFTZSIT-UHFFFAOYSA-N 264927 US9718790, I-1629 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264927 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264927&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020924 377003803 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504479 CC(C)Oc1ccc(Nc2nc(=O)n(CCNC(C)=O)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C23H25ClFN5O4/c1-14(2)34-20-9-8-18(12-19(20)25)27-21-28-22(32)29(11-10-26-15(3)31)23(33)30(21)13-16-4-6-17(24)7-5-16/h4-9,12,14H,10-11,13H2,1-3H3,(H,26,31)(H,27,28,32) VLKNEIAWFTVSEB-UHFFFAOYSA-N 183139 US9150546, I-292::US9688643, I-292::US9718790, I-0292 P2X purinoceptor 3 Homo sapiens 34.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183139 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183139&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 77393823 313634539 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504480 COC(=O)[C@H](C)[C@H](C)n1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(F)c2)n(Cc2ccc(C)cc2)c1=O 264929 US9718790, I-0967 P2X purinoceptor 3 Homo sapiens 19.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264929 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264929&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019531 377003805 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504481 CCc1oc2ccc(cc2c1C)\N=c1/[nH]c(=O)n(CCCC(O)=O)c(=O)n1Cc1ccc(C)cc1 InChI=1S/C26H28N4O5/c1-4-21-17(3)20-14-19(11-12-22(20)35-21)27-24-28-25(33)29(13-5-6-23(31)32)26(34)30(24)15-18-9-7-16(2)8-10-18/h7-12,14H,4-6,13,15H2,1-3H3,(H,31,32)(H,27,28,33) QNGZNLGGBNZQAS-UHFFFAOYSA-N 264930 US9718790, I-1630 P2X purinoceptor 3 Homo sapiens 15.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264930 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264930&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020934 377003806 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504482 CC(C)Oc1ccc(Nc2nc(=O)n(CC(=O)N(C)C)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C23H25ClFN5O4/c1-14(2)34-19-10-9-17(11-18(19)25)26-21-27-22(32)30(13-20(31)28(3)4)23(33)29(21)12-15-5-7-16(24)8-6-15/h5-11,14H,12-13H2,1-4H3,(H,26,27,32) RCVSMVSKFKNQJB-UHFFFAOYSA-N 183140 US9150546, I-293::US9688643, I-293::US9718790, I-0293 P2X purinoceptor 3 Homo sapiens 351 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183140 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183140&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821093 313634540 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504483 Cc1ccc(Cn2c(=O)n(CCC(O)=O)c(=O)[nH]\c2=N/c2ccc(OCC3CC3)c(Cl)c2)cc1 InChI=1S/C24H25ClN4O5/c1-15-2-4-16(5-3-15)13-29-22(27-23(32)28(24(29)33)11-10-21(30)31)26-18-8-9-20(19(25)12-18)34-14-17-6-7-17/h2-5,8-9,12,17H,6-7,10-11,13-14H2,1H3,(H,30,31)(H,26,27,32) KRRMRDKGDUBCGJ-UHFFFAOYSA-N 264932 US9718790, I-0968 P2X purinoceptor 3 Homo sapiens 107 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264932 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264932&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019547 377003808 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504484 CCc1nc2ccc(cc2s1)\N=c1/[nH]c(=O)n(CCCC(O)=O)c(=O)n1Cc1ccc(C)cc1 InChI=1S/C24H25N5O4S/c1-3-20-26-18-11-10-17(13-19(18)34-20)25-22-27-23(32)28(12-4-5-21(30)31)24(33)29(22)14-16-8-6-15(2)7-9-16/h6-11,13H,3-5,12,14H2,1-2H3,(H,30,31)(H,25,27,32) XBLMDBNCJDWYDK-UHFFFAOYSA-N 264933 US9718790, I-1631 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264933 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264933&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019771 377003809 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504485 CNC(=O)Cn1c(=O)nc(Nc2ccc(OC(C)C)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C22H23ClFN5O4/c1-13(2)33-18-9-8-16(10-17(18)24)26-20-27-21(31)29(12-19(30)25-3)22(32)28(20)11-14-4-6-15(23)7-5-14/h4-10,13H,11-12H2,1-3H3,(H,25,30)(H,26,27,31) PCFINRYADQXVKE-UHFFFAOYSA-N 183141 US9150546, I-294::US9688643, I-294::US9718790, I-0294 P2X purinoceptor 3 Homo sapiens 40.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183141 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183141&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76820949 313634541 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504486 COC(=O)[C@H](C)[C@H](C)n1c(=O)[nH]\c(=N/c2ccc(OCC3CC3)c(Cl)c2)n(Cc2ccc(C)cc2)c1=O 264935 US9718790, I-0969 P2X purinoceptor 3 Homo sapiens 47.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264935 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264935&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278544 377003811 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504487 OC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(OCc3cccnc3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H22ClN5O5/c26-19-5-3-17(4-6-19)15-31-23(29-24(34)30(25(31)35)13-11-22(32)33)28-20-7-9-21(10-8-20)36-16-18-2-1-12-27-14-18/h1-10,12,14H,11,13,15-16H2,(H,32,33)(H,28,29,34) LNYLYMZEKPMTNM-UHFFFAOYSA-N 264936 US9718790, I-1632 P2X purinoceptor 3 Homo sapiens 389 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264936 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264936&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019630 377003812 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504488 CC(C)Oc1ccc(Nc2nc(=O)n(CC(N)=O)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C21H21ClFN5O4/c1-12(2)32-17-8-7-15(9-16(17)23)25-19-26-20(30)28(11-18(24)29)21(31)27(19)10-13-3-5-14(22)6-4-13/h3-9,12H,10-11H2,1-2H3,(H2,24,29)(H,25,26,30) XUQJWMNWTZFCLU-UHFFFAOYSA-N 183142 US9150546, I-295::US9688643, I-295::US9718790, I-0295 P2X purinoceptor 3 Homo sapiens 46.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183142 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183142&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821065 313634542 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504489 CCOC(=O)C1(Cn2c(=O)[nH]\c(=N/c3ccc(OCC4CC4)c(Cl)c3)n(Cc3ccc(C)cc3)c2=O)CC1 InChI=1S/C28H31ClN4O5/c1-3-37-24(34)28(12-13-28)17-33-26(35)31-25(32(27(33)36)15-19-6-4-18(2)5-7-19)30-21-10-11-23(22(29)14-21)38-16-20-8-9-20/h4-7,10-11,14,20H,3,8-9,12-13,15-17H2,1-2H3,(H,30,31,35) DFESOKYUCOKAMK-UHFFFAOYSA-N 264938 US9718790, I-0970 P2X purinoceptor 3 Homo sapiens 20.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264938 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264938&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019534 377003814 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504490 CCc1oc2ccc(cc2c1C)\N=c1/[nH]c(=O)n(CCO)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C23H23ClN4O4/c1-3-19-14(2)18-12-17(8-9-20(18)32-19)25-21-26-22(30)27(10-11-29)23(31)28(21)13-15-4-6-16(24)7-5-15/h4-9,12,29H,3,10-11,13H2,1-2H3,(H,25,26,30) LHCXYFXOYZEPQP-UHFFFAOYSA-N 264939 US9718790, I-1633 P2X purinoceptor 3 Homo sapiens 16.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264939 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264939&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019777 377003815 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504491 CC(C)Oc1ccc(Nc2nc(=O)n(C(C)=O)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C21H20ClFN4O4/c1-12(2)31-18-9-8-16(10-17(18)23)24-19-25-20(29)27(13(3)28)21(30)26(19)11-14-4-6-15(22)7-5-14/h4-10,12H,11H2,1-3H3,(H,24,25,29) TZVHQOORWPGESA-UHFFFAOYSA-N 183143 US9150546, I-296::US9688643, I-296::US9718790, I-0296 P2X purinoceptor 3 Homo sapiens 176 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183143 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183143&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821385 313634543 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504492 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(OCC3CC3)c(Cl)c2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 264941 US9718790, I-0971 P2X purinoceptor 3 Homo sapiens 30.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264941 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264941&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945380 377003817 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504493 Cc1nc2ccc(cc2s1)\N=c1/[nH]c(=O)n(CC2(C)COC(C)(C)OC2)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C26H28ClN5O4S/c1-16-28-20-10-9-19(11-21(20)37-16)29-22-30-23(33)32(13-26(4)14-35-25(2,3)36-15-26)24(34)31(22)12-17-5-7-18(27)8-6-17/h5-11H,12-15H2,1-4H3,(H,29,30,33) KNCWIPNJVCPCGZ-UHFFFAOYSA-N 264942 US9718790, I-1635 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264942 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264942&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019582 377003818 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504494 CC(C)Oc1ccc(Nc2nc(=O)n(CCC(=O)N(C)C)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C24H27ClFN5O4/c1-15(2)35-20-10-9-18(13-19(20)26)27-22-28-23(33)30(12-11-21(32)29(3)4)24(34)31(22)14-16-5-7-17(25)8-6-16/h5-10,13,15H,11-12,14H2,1-4H3,(H,27,28,33) SNURGCWNVNKCDB-UHFFFAOYSA-N 183144 US9150546, I-297::US9688643, I-297::US9718790, I-0297 P2X purinoceptor 3 Homo sapiens 45.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183144 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183144&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821416 313634544 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504495 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc(OCC3CC3)cc2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 264944 US9718790, I-0972 P2X purinoceptor 3 Homo sapiens 38.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264944 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264944&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278545 377003820 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504496 CCc1oc2ccc(cc2c1C)\N=c1/[nH]c(=O)n(CC2(C)COC(C)(C)OC2)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C29H33ClN4O5/c1-6-23-18(2)22-13-21(11-12-24(22)39-23)31-25-32-26(35)34(15-29(5)16-37-28(3,4)38-17-29)27(36)33(25)14-19-7-9-20(30)10-8-19/h7-13H,6,14-17H2,1-5H3,(H,31,32,35) FZSIXEHPFXLMIV-UHFFFAOYSA-N 264945 US9718790, I-1636 P2X purinoceptor 3 Homo sapiens 9.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264945 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264945&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019954 377003821 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504497 CNC(=O)CCn1c(=O)nc(Nc2ccc(OC(C)C)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H25ClFN5O4/c1-14(2)34-19-9-8-17(12-18(19)25)27-21-28-22(32)29(11-10-20(31)26-3)23(33)30(21)13-15-4-6-16(24)7-5-15/h4-9,12,14H,10-11,13H2,1-3H3,(H,26,31)(H,27,28,32) XGSOCLWAPUYZQU-UHFFFAOYSA-N 183145 US9150546, I-298::US9688643, I-298::US9718790, I-0298 P2X purinoceptor 3 Homo sapiens 27.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183145 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183145&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821333 313634545 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504498 CCOc1ccc(cc1Cl)\N=c1/[nH]c(=O)n([C@@H](C)[C@@H](C)C(O)=O)c(=O)n1Cc1ccc(C)cc1 264947 US9718790, I-0973 P2X purinoceptor 3 Homo sapiens 19.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264947 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264947&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945069 377003823 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504499 CC(C)Cc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(CC(C)(CO)CO)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C25H30Cl2N4O4/c1-16(2)10-18-6-9-20(11-21(18)27)28-22-29-23(34)31(13-25(3,14-32)15-33)24(35)30(22)12-17-4-7-19(26)8-5-17/h4-9,11,16,32-33H,10,12-15H2,1-3H3,(H,28,29,34) KJLJNNPUHZPPCK-UHFFFAOYSA-N 264948 US9718790, I-1637 P2X purinoceptor 3 Homo sapiens 12.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264948 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264948&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019813 377003824 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504500 CC(C)Oc1ccc(Nc2nc(=O)n(CCC(N)=O)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C22H23ClFN5O4/c1-13(2)33-18-8-7-16(11-17(18)24)26-20-27-21(31)28(10-9-19(25)30)22(32)29(20)12-14-3-5-15(23)6-4-14/h3-8,11,13H,9-10,12H2,1-2H3,(H2,25,30)(H,26,27,31) UFFMZHJMYPBKRN-UHFFFAOYSA-N 183146 US9150546, I-299::US9688643, I-299::US9718790, I-0299 P2X purinoceptor 3 Homo sapiens 46.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183146 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183146&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821155 313634546 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504501 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n([C@@H](C)[C@@H](C)C(O)=O)c(=O)n1Cc1ccc(C)cc1 264950 US9718790, I-0974 P2X purinoceptor 3 Homo sapiens 29.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264950 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264950&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945207 377003826 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504502 COC(=O)CN1CCC(Cn2c(=O)[nH]\c(=N/c3ccc(OC(C)C)c(C)c3)n(Cc3ccc(Cl)cc3)c2=O)CC1 InChI=1S/C29H36ClN5O5/c1-19(2)40-25-10-9-24(15-20(25)3)31-27-32-28(37)35(17-22-11-13-33(14-12-22)18-26(36)39-4)29(38)34(27)16-21-5-7-23(30)8-6-21/h5-10,15,19,22H,11-14,16-18H2,1-4H3,(H,31,32,37) BSUPUJXAEJVENT-UHFFFAOYSA-N 264951 US9718790, I-1638 P2X purinoceptor 3 Homo sapiens 13.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264951 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264951&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945599 377003827 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504503 CC(C)Oc1ccc(Nc2nc(=O)n(Cc3ccccn3)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C25H23ClFN5O3/c1-16(2)35-22-11-10-19(13-21(22)27)29-23-30-24(33)32(15-20-5-3-4-12-28-20)25(34)31(23)14-17-6-8-18(26)9-7-17/h3-13,16H,14-15H2,1-2H3,(H,29,30,33) XXENJCJYUMNOPR-UHFFFAOYSA-N 183147 US9150546, I-300::US9688643, I-300::US9718790, I-0300 P2X purinoceptor 3 Homo sapiens 25.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183147 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183147&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821289 313634547 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504504 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc(OCC3CC3)c(Cl)c2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 264953 US9718790, I-0975 P2X purinoceptor 3 Homo sapiens 43.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264953 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264953&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278546 377003829 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504505 COC(=O)CN1CCC(CC1)n1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C28H34ClN5O5/c1-18(2)39-24-10-9-22(15-19(24)3)30-26-31-27(36)34(23-11-13-32(14-12-23)17-25(35)38-4)28(37)33(26)16-20-5-7-21(29)8-6-20/h5-10,15,18,23H,11-14,16-17H2,1-4H3,(H,30,31,36) KVNWQHBJWAMALK-UHFFFAOYSA-N 264954 US9718790, I-1639 P2X purinoceptor 3 Homo sapiens 14.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264954 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264954&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278284 377003830 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504506 CC(C)Oc1ccc(Nc2nc(=O)n(Cc3ccccc3)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C26H24ClFN4O3/c1-17(2)35-23-13-12-21(14-22(23)28)29-24-30-25(33)32(16-18-6-4-3-5-7-18)26(34)31(24)15-19-8-10-20(27)11-9-19/h3-14,17H,15-16H2,1-2H3,(H,29,30,33) CRXFJQFRHPYGEW-UHFFFAOYSA-N 183148 US9150546, I-301::US9688643, I-301::US9718790, I-0301 P2X purinoceptor 3 Homo sapiens 48.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183148 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183148&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821148 313634548 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504507 Cc1ccc(Cn2c(=O)n(CC3(CC3)C(O)=O)c(=O)[nH]\c2=N/c2ccc(OCC3CC3)c(Cl)c2)cc1 InChI=1S/C26H27ClN4O5/c1-16-2-4-17(5-3-16)13-30-23(28-19-8-9-21(20(27)12-19)36-14-18-6-7-18)29-24(34)31(25(30)35)15-26(10-11-26)22(32)33/h2-5,8-9,12,18H,6-7,10-11,13-15H2,1H3,(H,32,33)(H,28,29,34) GZVHUSOOLJPWRN-UHFFFAOYSA-N 264956 US9718790, I-0976 P2X purinoceptor 3 Homo sapiens 69.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264956 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264956&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020479 377003832 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504508 CC(C)Oc1ccc(cc1C)\N=c1/[nH]c(=O)n(CC2CN(C2)C(=O)OC(C)(C)C)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C29H36ClN5O5/c1-18(2)39-24-12-11-23(13-19(24)3)31-25-32-26(36)35(17-21-14-33(15-21)28(38)40-29(4,5)6)27(37)34(25)16-20-7-9-22(30)10-8-20/h7-13,18,21H,14-17H2,1-6H3,(H,31,32,36) QXJWKUSQOZJDSY-UHFFFAOYSA-N 264957 US9718790, I-1640 P2X purinoceptor 3 Homo sapiens 13.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264957 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264957&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019815 377003833 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504509 COc1ccc(Nc2nc(=O)n(CCO)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C19H18ClFN4O4/c1-29-16-7-6-14(10-15(16)21)22-17-23-18(27)24(8-9-26)19(28)25(17)11-12-2-4-13(20)5-3-12/h2-7,10,26H,8-9,11H2,1H3,(H,22,23,27) VQLURVNMKVRPBI-UHFFFAOYSA-N 183149 US9150546, I-305::US9688643, I-305::US9718790, I-0305 P2X purinoceptor 3 Homo sapiens 946 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183149 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183149&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821291 313634549 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504510 COC(=O)CC1(Cn2c(=O)[nH]\c(=N/c3ccc(OC(C)C)c(Cl)c3)n(Cc3ccc(Cl)cc3)c2=O)CC1 InChI=1S/C26H28Cl2N4O5/c1-16(2)37-21-9-8-19(12-20(21)28)29-23-30-24(34)32(15-26(10-11-26)13-22(33)36-3)25(35)31(23)14-17-4-6-18(27)7-5-17/h4-9,12,16H,10-11,13-15H2,1-3H3,(H,29,30,34) ZMTZNVODXCQNNM-UHFFFAOYSA-N 264959 US9718790, I-0977 P2X purinoceptor 3 Homo sapiens 15.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264959 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264959&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278476 377003835 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504511 CC(C)Oc1ccc(cc1C)\N=c1/[nH]c(=O)n(C2CN(C2)C(=O)OC(C)(C)C)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C28H34ClN5O5/c1-17(2)38-23-12-11-21(13-18(23)3)30-24-31-25(35)34(22-15-32(16-22)27(37)39-28(4,5)6)26(36)33(24)14-19-7-9-20(29)10-8-19/h7-13,17,22H,14-16H2,1-6H3,(H,30,31,35) XRRWTHGOMGTJPQ-UHFFFAOYSA-N 264960 US9718790, I-1641 P2X purinoceptor 3 Homo sapiens 20.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264960 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264960&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019981 377003836 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504512 CCOc1ccc(Nc2nc(=O)n(CCO)c(=O)n2Cc2ccc(Cl)cc2)cc1 InChI=1S/C20H21ClN4O4/c1-2-29-17-9-7-16(8-10-17)22-18-23-19(27)24(11-12-26)20(28)25(18)13-14-3-5-15(21)6-4-14/h3-10,26H,2,11-13H2,1H3,(H,22,23,27) PCNUGCNYROAAGW-UHFFFAOYSA-N 183150 US9150546, I-307::US9688643, I-307::US9718790, I-0307 P2X purinoceptor 3 Homo sapiens 250 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183150 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183150&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821438 313634550 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504513 COC(=O)CC1(Cn2c(=O)[nH]\c(=N/c3ccc(OC(C)C)c(C)c3)n(Cc3ccc(Cl)cc3)c2=O)CC1 InChI=1S/C27H31ClN4O5/c1-17(2)37-22-10-9-21(13-18(22)3)29-24-30-25(34)32(16-27(11-12-27)14-23(33)36-4)26(35)31(24)15-19-5-7-20(28)8-6-19/h5-10,13,17H,11-12,14-16H2,1-4H3,(H,29,30,34) RHUUVJLVTRRRJM-UHFFFAOYSA-N 264962 US9718790, I-0978 P2X purinoceptor 3 Homo sapiens 13.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264962 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264962&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945080 377003838 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504514 CC1(C)OCC(Cn2c(=O)nc(Cc3cccc(c3)C(F)(F)F)n(Cc3ccc(Cl)cc3)c2=O)CO1 InChI=1S/C25H25ClF3N3O4/c1-24(2)35-14-18(15-36-24)13-32-22(33)30-21(11-17-4-3-5-19(10-17)25(27,28)29)31(23(32)34)12-16-6-8-20(26)9-7-16/h3-10,18H,11-15H2,1-2H3 WUHRECZNFQNFHW-UHFFFAOYSA-N 264963 US9718790, I-1642 P2X purinoceptor 3 Homo sapiens 551 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264963 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264963&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 77388173 377003839 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504515 OCCn1c(=O)nc(Nc2cccc(OC(F)(F)F)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C19H16ClF3N4O4/c20-13-6-4-12(5-7-13)11-27-16(25-17(29)26(8-9-28)18(27)30)24-14-2-1-3-15(10-14)31-19(21,22)23/h1-7,10,28H,8-9,11H2,(H,24,25,29) SZPOVAGBNOSRKL-UHFFFAOYSA-N 183151 US9150546, I-309::US9688643, I-309::US9718790, I-0309 P2X purinoceptor 3 Homo sapiens 357 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183151 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183151&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821085 313634551 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504516 COC(=O)CC1(Cn2c(=O)[nH]\c(=N/c3ccc(OC(C)C)c(Cl)c3)n(Cc3ccc(C)cc3)c2=O)CC1 InChI=1S/C27H31ClN4O5/c1-17(2)37-22-10-9-20(13-21(22)28)29-24-30-25(34)32(16-27(11-12-27)14-23(33)36-4)26(35)31(24)15-19-7-5-18(3)6-8-19/h5-10,13,17H,11-12,14-16H2,1-4H3,(H,29,30,34) OZJJJLSFTKBAKH-UHFFFAOYSA-N 264965 US9718790, I-0979 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264965 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264965&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945145 377003841 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504517 Cc1nc2ccc(cc2s1)\N=c1/[nH]c(=O)n(CC(C)(CO)CO)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C23H24ClN5O4S/c1-14-25-18-8-7-17(9-19(18)34-14)26-20-27-21(32)29(11-23(2,12-30)13-31)22(33)28(20)10-15-3-5-16(24)6-4-15/h3-9,30-31H,10-13H2,1-2H3,(H,26,27,32) UXOXHPHWPGRCSQ-UHFFFAOYSA-N 264966 US9718790, I-1643 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264966 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264966&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945499 377003842 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504518 CC(C)Oc1ccc(Nc2nc(=O)n(C(F)F)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C20H18ClF3N4O3/c1-11(2)31-16-8-7-14(9-15(16)22)25-18-26-19(29)28(17(23)24)20(30)27(18)10-12-3-5-13(21)6-4-12/h3-9,11,17H,10H2,1-2H3,(H,25,26,29) UKOOLOVTENGDOT-UHFFFAOYSA-N 183152 US9150546, I-310::US9688643, I-310::US9718790, I-0310 P2X purinoceptor 3 Homo sapiens 389 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183152 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183152&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821325 313634552 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504519 COC(=O)CC1(Cn2c(=O)[nH]\c(=N/c3ccc(OC(C)C)c(C)c3)n(Cc3ccc(C)cc3)c2=O)CC1 InChI=1S/C28H34N4O5/c1-18(2)37-23-11-10-22(14-20(23)4)29-25-30-26(34)32(17-28(12-13-28)15-24(33)36-5)27(35)31(25)16-21-8-6-19(3)7-9-21/h6-11,14,18H,12-13,15-17H2,1-5H3,(H,29,30,34) JHLOLSLPCDVDQQ-UHFFFAOYSA-N 264968 US9718790, I-0980 P2X purinoceptor 3 Homo sapiens 11.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264968 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264968&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945139 377003844 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504520 CCc1oc2ccc(cc2c1C)\N=c1/[nH]c(=O)n(CC(C)(CO)CO)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C26H29ClN4O5/c1-4-21-16(2)20-11-19(9-10-22(20)36-21)28-23-29-24(34)31(13-26(3,14-32)15-33)25(35)30(23)12-17-5-7-18(27)8-6-17/h5-11,32-33H,4,12-15H2,1-3H3,(H,28,29,34) PHDTTXITWQGZHW-UHFFFAOYSA-N 264969 US9718790, I-1644 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264969 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264969&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020025 377003845 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504521 OCCn1c(=O)nc(Nc2ccc(cc2)N2CCCCC2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H26ClN5O3/c24-18-6-4-17(5-7-18)16-29-21(26-22(31)28(14-15-30)23(29)32)25-19-8-10-20(11-9-19)27-12-2-1-3-13-27/h4-11,30H,1-3,12-16H2,(H,25,26,31) OJQRPQPOPGAGNZ-UHFFFAOYSA-N 183153 US9150546, I-311::US9688643, I-311::US9718790, I-0311 P2X purinoceptor 3 Homo sapiens 142 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183153 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183153&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821457 313634553 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504522 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(CC2(CC(O)=O)CC2)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C25H26Cl2N4O5/c1-15(2)36-20-8-7-18(11-19(20)27)28-22-29-23(34)31(14-25(9-10-25)12-21(32)33)24(35)30(22)13-16-3-5-17(26)6-4-16/h3-8,11,15H,9-10,12-14H2,1-2H3,(H,32,33)(H,28,29,34) NYRKWUYEIZYKTC-UHFFFAOYSA-N 264971 US9718790, I-0981 P2X purinoceptor 3 Homo sapiens 10.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264971 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264971&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020185 377003847 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504523 CCOC(=O)CCn1c(=O)[nH]\c(=N/c2cccc(c2)S(F)(F)(F)(F)F)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C21H20ClF5N4O4S/c1-2-35-18(32)10-11-30-20(33)29-19(31(21(30)34)13-14-6-8-15(22)9-7-14)28-16-4-3-5-17(12-16)36(23,24,25,26)27/h3-9,12H,2,10-11,13H2,1H3,(H,28,29,33) NXIAYPMFWJSMIN-UHFFFAOYSA-N 264972 US9718790, I-1646 P2X purinoceptor 3 Homo sapiens 43.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264972 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264972&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 88558744 377003848 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504524 CCOc1ccc(Nc2nc(=O)n(CCO)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C20H20ClFN4O4/c1-2-30-17-8-7-15(11-16(17)22)23-18-24-19(28)25(9-10-27)20(29)26(18)12-13-3-5-14(21)6-4-13/h3-8,11,27H,2,9-10,12H2,1H3,(H,23,24,28) UVRGSNWJIMHPJR-UHFFFAOYSA-N 183154 US9150546, I-312::US9688643, I-312::US9718790, I-0312 P2X purinoceptor 3 Homo sapiens 104 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183154 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183154&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76820982 313634554 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504525 CC(C)Oc1ccc(cc1C)\N=c1/[nH]c(=O)n(CC2(CC(O)=O)CC2)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C26H29ClN4O5/c1-16(2)36-21-9-8-20(12-17(21)3)28-23-29-24(34)31(15-26(10-11-26)13-22(32)33)25(35)30(23)14-18-4-6-19(27)7-5-18/h4-9,12,16H,10-11,13-15H2,1-3H3,(H,32,33)(H,28,29,34) JWFTXQDFKUTBIO-UHFFFAOYSA-N 264974 US9718790, I-0982 P2X purinoceptor 3 Homo sapiens 17.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264974 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264974&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020135 377003850 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504527 OCCn1c(=O)nc(Nc2cccc(c2)C(F)(F)F)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C19H16ClF3N4O3/c20-14-6-4-12(5-7-14)11-27-16(25-17(29)26(8-9-28)18(27)30)24-15-3-1-2-13(10-15)19(21,22)23/h1-7,10,28H,8-9,11H2,(H,24,25,29) GNJMVKXDASLTBV-UHFFFAOYSA-N 183155 US9150546, I-313::US9688643, I-313::US9718790, I-0313 P2X purinoceptor 3 Homo sapiens 178 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183155 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183155&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821293 313634555 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504528 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(CC2(CC(O)=O)CC2)c(=O)n1Cc1ccc(C)cc1 InChI=1S/C26H29ClN4O5/c1-16(2)36-21-9-8-19(12-20(21)27)28-23-29-24(34)31(15-26(10-11-26)13-22(32)33)25(35)30(23)14-18-6-4-17(3)5-7-18/h4-9,12,16H,10-11,13-15H2,1-3H3,(H,32,33)(H,28,29,34) RJCCUKWECWONFW-UHFFFAOYSA-N 264976 US9718790, I-0983 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264976 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264976&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020439 377003852 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504529 CC(C)Oc1ccc(cc1C)\N=c1/[nH]c(=O)n(CC2CCN(CC(O)=O)CC2)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C28H34ClN5O5/c1-18(2)39-24-9-8-23(14-19(24)3)30-26-31-27(37)34(16-21-10-12-32(13-11-21)17-25(35)36)28(38)33(26)15-20-4-6-22(29)7-5-20/h4-9,14,18,21H,10-13,15-17H2,1-3H3,(H,35,36)(H,30,31,37) OSNRSROMQMUGPH-UHFFFAOYSA-N 264977 US9718790, I-1648 P2X purinoceptor 3 Homo sapiens 160 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264977 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264977&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945496 377003853 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504530 OCCn1c(=O)nc(Nc2cccc(c2)-c2ccon2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C21H18ClN5O4/c22-16-6-4-14(5-7-16)13-27-19(24-20(29)26(9-10-28)21(27)30)23-17-3-1-2-15(12-17)18-8-11-31-25-18/h1-8,11-12,28H,9-10,13H2,(H,23,24,29) DDPKJFUGSSHNQH-UHFFFAOYSA-N 183156 US9150546, I-314::US9688643, I-314::US9718790, I-0314 P2X purinoceptor 3 Homo sapiens 555 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183156 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183156&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821005 313634556 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504531 CC(C)Oc1ccc(cc1C)\N=c1/[nH]c(=O)n(CC2(CC(O)=O)CC2)c(=O)n1Cc1ccc(C)cc1 InChI=1S/C27H32N4O5/c1-17(2)36-22-10-9-21(13-19(22)4)28-24-29-25(34)31(16-27(11-12-27)14-23(32)33)26(35)30(24)15-20-7-5-18(3)6-8-20/h5-10,13,17H,11-12,14-16H2,1-4H3,(H,32,33)(H,28,29,34) VQWIQONGZWBYIK-UHFFFAOYSA-N 264979 US9718790, I-0984 P2X purinoceptor 3 Homo sapiens 21.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264979 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264979&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020245 377003855 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504532 CC(C)Oc1ccc(cc1C)\N=c1/[nH]c(=O)n(C2CCN(CC(O)=O)CC2)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C27H32ClN5O5/c1-17(2)38-23-9-8-21(14-18(23)3)29-25-30-26(36)33(22-10-12-31(13-11-22)16-24(34)35)27(37)32(25)15-19-4-6-20(28)7-5-19/h4-9,14,17,22H,10-13,15-16H2,1-3H3,(H,34,35)(H,29,30,36) ZVBPGQRKOYOOMZ-UHFFFAOYSA-N 264980 US9718790, I-1649 P2X purinoceptor 3 Homo sapiens 285 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264980 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264980&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019687 377003856 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504533 OCCn1c(=O)nc(Nc2ccc(c(F)c2)C(F)(F)F)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C19H15ClF4N4O3/c20-12-3-1-11(2-4-12)10-28-16(26-17(30)27(7-8-29)18(28)31)25-13-5-6-14(15(21)9-13)19(22,23)24/h1-6,9,29H,7-8,10H2,(H,25,26,30) DGUIURWTUWHUDG-UHFFFAOYSA-N 183157 US9150546, I-315::US9688643, I-315::US9718790, I-0315 P2X purinoceptor 3 Homo sapiens 183 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183157 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183157&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821237 313634557 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504934 C[C@@H](Oc1ccc(cc1)\N=c1/[nH]c(=O)n(C[C@H](O)CO)c(=O)n1Cc1ccc(Cl)cc1)C(F)(F)F 265380 US9718790, I-1845 P2X purinoceptor 3 Homo sapiens 33.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265380 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265380&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019852 377004255 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504935 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(C[C@@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 183291 US9150546, I-460::US9688643, I-460::US9718790, I-0469 P2X purinoceptor 3 Homo sapiens 16.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183291 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183291&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578529 313634691 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504957 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2cccc(CC(C)C)c2)n(Cc2ccc(C)cc2)c1=O 265402 US9718790, I-1132 P2X purinoceptor 3 Homo sapiens 586 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265402 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265402&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020842 377004277 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504958 CC1(C)OC[C@H](Cn2c(=O)[nH]\c(=N/c3ccc(OCC4CC4)cc3)n(Cc3ccc(Cl)cc3)c2=O)O1 265403 US9718790, I-1854 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265403 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265403&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278568 377004278 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504959 CC(C)(Cn1c(=O)[nH]\c(=N/c2cccc(Cl)c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O InChI=1S/C21H20Cl2N4O4/c1-21(2,17(28)29)12-27-19(30)25-18(24-16-5-3-4-15(23)10-16)26(20(27)31)11-13-6-8-14(22)9-7-13/h3-10H,11-12H2,1-2H3,(H,28,29)(H,24,25,30) VRQZGCHSOQRPQF-UHFFFAOYSA-N 183299 US9150546, I-468::US9688643, I-468::US9718790, I-0477 P2X purinoceptor 3 Homo sapiens 137 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183299 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183299&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578413 313634699 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504960 CCc1ccc(Cn2\c(=N\c3ccc(OC(C)C)cc3)[nH]c(=O)n(C[C@H](C)C(=O)OC)c2=O)cc1 265405 US9718790, I-1133 P2X purinoceptor 3 Homo sapiens 51.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265405 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265405&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020864 377004280 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504961 OC[C@@H](O)Cn1c(=O)[nH]\c(=N/c2ccc(OCC3CC3)cc2)n(Cc2ccc(Cl)cc2)c1=O 265406 US9718790, I-1855 P2X purinoceptor 3 Homo sapiens 21.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265406 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265406&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278569 377004281 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504962 CC(C)(Cn1c(=O)[nH]\c(=N/c2cccc(OC(F)(F)F)c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O InChI=1S/C22H20ClF3N4O5/c1-21(2,17(31)32)12-30-19(33)28-18(27-15-4-3-5-16(10-15)35-22(24,25)26)29(20(30)34)11-13-6-8-14(23)9-7-13/h3-10H,11-12H2,1-2H3,(H,31,32)(H,27,28,33) OFBGTHRBXJQAKW-UHFFFAOYSA-N 183300 US9150546, I-469::US9688643, I-469::US9718790, I-0478 P2X purinoceptor 3 Homo sapiens 101 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183300 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183300&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578601 313634700 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504963 CC(C)Oc1ccc(cc1O)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(C)cc1 265408 US9718790, I-1134 P2X purinoceptor 3 Homo sapiens 35.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265408 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265408&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020843 377004283 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504964 COc1ccc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(CC(N)=O)c(=O)n2Cc2ccc(Cl)cc2)cn1 InChI=1S/C24H21ClN6O5/c1-35-21-11-10-19(12-27-21)36-18-8-6-17(7-9-18)28-22-29-23(33)31(14-20(26)32)24(34)30(22)13-15-2-4-16(25)5-3-15/h2-12H,13-14H2,1H3,(H2,26,32)(H,28,29,33) UFUVHTWHWVNCPZ-UHFFFAOYSA-N 265409 US9718790, I-1856 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265409 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265409&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945558 377004284 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504965 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc3[nH]ccc3c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H24ClN5O4/c1-24(2,20(31)34-3)14-30-22(32)28-21(27-18-8-9-19-16(12-18)10-11-26-19)29(23(30)33)13-15-4-6-17(25)7-5-15/h4-12,26H,13-14H2,1-3H3,(H,27,28,32) QUUJAAQFGPTNJB-UHFFFAOYSA-N 183301 US9150546, I-470::US9688643, I-470::US9718790, I-0479 P2X purinoceptor 3 Homo sapiens 80.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183301 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183301&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578909 313634701 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504966 COc1cc(ccc1OC(C)C)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(C)cc1 265411 US9718790, I-1135 P2X purinoceptor 3 Homo sapiens 18.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265411 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265411&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020841 377004286 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504967 CNC(=O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(OC)nc3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H23ClN6O5/c1-27-21(33)15-32-24(34)30-23(31(25(32)35)14-16-3-5-17(26)6-4-16)29-18-7-9-19(10-8-18)37-20-11-12-22(36-2)28-13-20/h3-13H,14-15H2,1-2H3,(H,27,33)(H,29,30,34) TUHVSBNXQIRQDK-UHFFFAOYSA-N 265412 US9718790, I-1857 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265412 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265412&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945551 377004287 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504968 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2cccc(c2)C(F)(F)F)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H22ClF3N4O4/c1-22(2,18(32)35-3)13-31-20(33)29-19(28-17-6-4-5-15(11-17)23(25,26)27)30(21(31)34)12-14-7-9-16(24)10-8-14/h4-11H,12-13H2,1-3H3,(H,28,29,33) RKIAQDSYNKVHJJ-UHFFFAOYSA-N 183302 US9150546, I-471::US9688643, I-471::US9718790, I-0480 P2X purinoceptor 3 Homo sapiens 24.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183302 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183302&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578429 313634702 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504969 CC(C)Oc1ccc(cc1OC(C)C)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(C)cc1 265414 US9718790, I-1136 P2X purinoceptor 3 Homo sapiens 204 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265414 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265414&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021051 377004289 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504970 COc1ccc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(CC(=O)NCCO)c(=O)n2Cc2ccc(Cl)cc2)cn1 InChI=1S/C26H25ClN6O6/c1-38-23-11-10-21(14-29-23)39-20-8-6-19(7-9-20)30-24-31-25(36)33(16-22(35)28-12-13-34)26(37)32(24)15-17-2-4-18(27)5-3-17/h2-11,14,34H,12-13,15-16H2,1H3,(H,28,35)(H,30,31,36) JLXFWJLTTSWLJQ-UHFFFAOYSA-N 265415 US9718790, I-1858 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265415 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265415&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130279126 377004290 C04080 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504971 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(Cl)c(Cl)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C22H21Cl3N4O4/c1-22(2,18(30)33-3)12-29-20(31)27-19(26-15-8-9-16(24)17(25)10-15)28(21(29)32)11-13-4-6-14(23)7-5-13/h4-10H,11-12H2,1-3H3,(H,26,27,31) RDLMYGPENFGHLI-UHFFFAOYSA-N 183303 US9150546, I-472::US9688643, I-472::US9718790, I-0481 P2X purinoceptor 3 Homo sapiens 47.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183303 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183303&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578666 313634703 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504972 CC(C)Cc1cccc(c1)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(C)cc1 265417 US9718790, I-1137 P2X purinoceptor 3 Homo sapiens 678 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265417 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265417&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945178 377004292 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504973 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cc(OC)ncn3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H21ClN6O4/c1-3-29-22(31)28-21(30(23(29)32)13-15-4-6-16(24)7-5-15)27-17-8-10-18(11-9-17)34-20-12-19(33-2)25-14-26-20/h4-12,14H,3,13H2,1-2H3,(H,27,28,31) PZOWSIMTVVKSHB-UHFFFAOYSA-N 265418 US9718790, I-1859 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265418 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265418&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278606 377004293 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504974 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)nc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H28ClN5O5/c1-15(2)35-19-11-10-18(12-26-19)27-21-28-22(32)30(14-24(3,4)20(31)34-5)23(33)29(21)13-16-6-8-17(25)9-7-16/h6-12,15H,13-14H2,1-5H3,(H,27,28,32) BSTAKLZFGBHMOK-UHFFFAOYSA-N 183304 US9150546, I-473::US9688643, I-473::US9718790, I-0482 P2X purinoceptor 3 Homo sapiens 583 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183304 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183304&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578441 313634704 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504975 CC(C)Oc1ccc(cc1)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(C=C)cc1 265420 US9718790, I-1139 P2X purinoceptor 3 Homo sapiens 52.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265420 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265420&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278224 377004295 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504976 CCOC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(F)c2)n(CC2C[C@H]3CC[C@@H]2C3)c1=O 265421 US9718790, I-1860 P2X purinoceptor 3 Homo sapiens 150 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265421 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265421&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278407 377004296 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504977 COC(=O)C(C)n1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O 183305 US9150546, I-474::US9688643, I-474::US9718790, I-0483 P2X purinoceptor 3 Homo sapiens 14.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183305 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183305&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578472 313634705 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504978 CCc1ccc(Cn2c(=O)n(C[C@H](C)C(O)=O)c(=O)[nH]\c2=N/c2ccc(OC(C)C)cc2)cc1 265423 US9718790, I-1140 P2X purinoceptor 3 Homo sapiens 44.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265423 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265423&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278225 377004298 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504979 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n(CCC(O)=O)c(=O)n1CC1C[C@H]2CC[C@@H]1C2 265424 US9718790, I-1862 P2X purinoceptor 3 Homo sapiens 552 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265424 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265424&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278408 377004299 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504980 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n(C(C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 183306 US9150546, I-475::US9688643, I-475::US9718790, I-0484 P2X purinoceptor 3 Homo sapiens 571 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183306 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183306&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578660 313634706 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504981 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)cc2)n(Cc2ccc(\C=C\C)cc2)c1=O 265426 US9718790, I-1141 P2X purinoceptor 3 Homo sapiens 911 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265426 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265426&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020183 377004301 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504982 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cncc(c3)C(=O)OC)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H22ClN5O5/c1-3-30-24(33)29-23(31(25(30)34)15-16-4-6-18(26)7-5-16)28-19-8-10-20(11-9-19)36-21-12-17(13-27-14-21)22(32)35-2/h4-14H,3,15H2,1-2H3,(H,28,29,33) DIDNDDFRQLKWKZ-UHFFFAOYSA-N 265427 US9718790, I-1863 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265427 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265427&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278294 377004302 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504983 CC(C)(Cn1c(=O)[nH]\c(=N/c2cccc(c2)C(F)(F)F)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O InChI=1S/C22H20ClF3N4O4/c1-21(2,17(31)32)12-30-19(33)28-18(27-16-5-3-4-14(10-16)22(24,25)26)29(20(30)34)11-13-6-8-15(23)9-7-13/h3-10H,11-12H2,1-2H3,(H,31,32)(H,27,28,33) GWKWQVXRPIJDAM-UHFFFAOYSA-N 183307 US9150546, I-476::US9688643, I-476::US9718790, I-0485 P2X purinoceptor 3 Homo sapiens 35.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183307 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183307&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578436 313634707 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504984 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)cc2)n(Cc2ccc(\C=C/C)cc2)c1=O 265429 US9718790, I-1142 P2X purinoceptor 3 Homo sapiens 802 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265429 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265429&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278303 377004304 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504985 CCOc1ccc(Cc2nc(=O)n(C[C@H](C)C(=O)OC)c(=O)n2Cc2ccc(Cl)cc2)cc1 InChI=1S/C24H26ClN3O5/c1-4-33-20-11-7-17(8-12-20)13-21-26-23(30)28(14-16(2)22(29)32-3)24(31)27(21)15-18-5-9-19(25)10-6-18/h5-12,16H,4,13-15H2,1-3H3/t16-/m0/s1 JSNYIRWJDLYFEA-INIZCTEOSA-N 265430 US9718790, I-1864 P2X purinoceptor 3 Homo sapiens 186 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265430 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265430&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 135121005 377004305 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504986 CC(C)(Cn1c(=O)[nH]\c(=N/c2ccc(Cl)c(Cl)c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O InChI=1S/C21H19Cl3N4O4/c1-21(2,17(29)30)11-28-19(31)26-18(25-14-7-8-15(23)16(24)9-14)27(20(28)32)10-12-3-5-13(22)6-4-12/h3-9H,10-11H2,1-2H3,(H,29,30)(H,25,26,31) VMTZHIZQTJWQIE-UHFFFAOYSA-N 183308 US9150546, I-477::US9688643, I-477::US9718790, I-0486 P2X purinoceptor 3 Homo sapiens 56.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183308 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183308&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578604 313634708 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504987 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(Cl)c2)n(Cc2ccc(OC)cc2)c1=O 265432 US9718790, I-1143 P2X purinoceptor 3 Homo sapiens 24.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265432 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265432&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019489 377004307 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504988 COC(=O)[C@@H](C)Cn1c(=O)nc(Cc2ccccc2C)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H24ClN3O4/c1-15-6-4-5-7-18(15)12-20-25-22(29)27(13-16(2)21(28)31-3)23(30)26(20)14-17-8-10-19(24)11-9-17/h4-11,16H,12-14H2,1-3H3/t16-/m0/s1 CDKTYZYUEVIVLN-INIZCTEOSA-N 265433 US9718790, I-1865 P2X purinoceptor 3 Homo sapiens 357 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265433 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265433&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 135121006 377004308 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504989 CC(C)(Cn1c(=O)[nH]\c(=N/c2ccc3[nH]ccc3c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O InChI=1S/C23H22ClN5O4/c1-23(2,19(30)31)13-29-21(32)27-20(26-17-7-8-18-15(11-17)9-10-25-18)28(22(29)33)12-14-3-5-16(24)6-4-14/h3-11,25H,12-13H2,1-2H3,(H,30,31)(H,26,27,32) CISPGXOHZZTVHA-UHFFFAOYSA-N 183309 US9150546, I-478::US9688643, I-478::US9718790, I-0487 P2X purinoceptor 3 Homo sapiens 629 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183309 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183309&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578908 313634709 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504990 CCCc1ccc(Cn2\c(=N\c3ccc(OC(C)C)cc3)[nH]c(=O)n(C[C@H](C)C(=O)OC)c2=O)cc1 265435 US9718790, I-1144 P2X purinoceptor 3 Homo sapiens 764 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265435 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265435&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945189 377004310 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504991 COC(=O)[C@@H](C)Cn1c(=O)nc(Cc2ccc(OC)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H23ClFN3O5/c1-14(21(29)33-3)12-28-22(30)26-20(11-16-6-9-19(32-2)18(25)10-16)27(23(28)31)13-15-4-7-17(24)8-5-15/h4-10,14H,11-13H2,1-3H3/t14-/m0/s1 VARFFWZDEXDFPX-AWEZNQCLSA-N 265436 US9718790, I-1869 P2X purinoceptor 3 Homo sapiens 328 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265436 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265436&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 135121007 377004311 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504992 COC(=O)[C@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)cc2)n(Cc2ccc(Cl)cc2)c1=O 183310 US9150546, I-479::US9688643, I-479::US9718790, I-0488 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183310 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183310&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578589 313634710 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504993 CCOC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(OCC3CC3)cc2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C26H30N4O5/c1-3-34-23(31)14-15-29-25(32)28-24(30(26(29)33)16-19-6-4-18(2)5-7-19)27-21-10-12-22(13-11-21)35-17-20-8-9-20/h4-7,10-13,20H,3,8-9,14-17H2,1-2H3,(H,27,28,32) YMXXPTYBIHNNCN-UHFFFAOYSA-N 265438 US9718790, I-1146 P2X purinoceptor 3 Homo sapiens 9.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265438 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265438&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945368 377004313 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504994 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(cc3)C(N)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H22ClN5O4/c1-2-30-24(33)29-23(31(25(30)34)15-16-3-7-18(26)8-4-16)28-19-9-13-21(14-10-19)35-20-11-5-17(6-12-20)22(27)32/h3-14H,2,15H2,1H3,(H2,27,32)(H,28,29,33) JVZRQQKMHKTTLH-UHFFFAOYSA-N 265439 US9718790, I-1870 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265439 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265439&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019592 377004314 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504995 CCOc1ccc(cc1)\N=c1/[nH]c(=O)n(C[C@@H](C)C(=O)OC)c(=O)n1Cc1ccc(Cl)cc1 183311 US9150546, I-480::US9688643, I-480::US9718790, I-0489 P2X purinoceptor 3 Homo sapiens 12.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183311 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183311&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578937 313634711 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504996 CCOC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(OCC3CC3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H27ClN4O5/c1-2-34-22(31)13-14-29-24(32)28-23(30(25(29)33)15-17-5-7-19(26)8-6-17)27-20-9-11-21(12-10-20)35-16-18-3-4-18/h5-12,18H,2-4,13-16H2,1H3,(H,27,28,32) ZVVUJDNEBCZNSI-UHFFFAOYSA-N 265441 US9718790, I-1147 P2X purinoceptor 3 Homo sapiens 10.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265441 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265441&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278227 377004316 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504997 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(NC(C)=O)cc3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H24ClN5O4/c1-3-31-25(34)30-24(32(26(31)35)16-18-4-6-19(27)7-5-18)29-21-10-14-23(15-11-21)36-22-12-8-20(9-13-22)28-17(2)33/h4-15H,3,16H2,1-2H3,(H,28,33)(H,29,30,34) YDWRDXBHTOTOQI-UHFFFAOYSA-N 265442 US9718790, I-1871 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265442 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265442&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278295 377004317 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504998 CCOc1ccc(cc1C)\N=c1/[nH]c(=O)n(C[C@@H](C)C(=O)OC)c(=O)n1Cc1ccc(Cl)cc1 183312 US9150546, I-481::US9688643, I-481::US9718790, I-0490 P2X purinoceptor 3 Homo sapiens 12.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183312 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183312&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578417 313634712 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504999 Cc1ccc(Cn2c(=O)n(CCC(O)=O)c(=O)[nH]\c2=N/c2ccc(OCC3CC3)cc2)cc1 InChI=1S/C24H26N4O5/c1-16-2-4-17(5-3-16)14-28-22(26-23(31)27(24(28)32)13-12-21(29)30)25-19-8-10-20(11-9-19)33-15-18-6-7-18/h2-5,8-11,18H,6-7,12-15H2,1H3,(H,29,30)(H,25,26,31) BRQJFTAWMXQPAQ-UHFFFAOYSA-N 265444 US9718790, I-1148::US9718790, I-1149 P2X purinoceptor 3 Homo sapiens 86.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265444 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265444&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278228 377004319 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505000 CCOC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(F)cc3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C27H24ClFN4O5/c1-2-37-24(34)15-16-32-26(35)31-25(33(27(32)36)17-18-3-5-19(28)6-4-18)30-21-9-13-23(14-10-21)38-22-11-7-20(29)8-12-22/h3-14H,2,15-17H2,1H3,(H,30,31,35) NAAJFELZMZLKGN-UHFFFAOYSA-N 265445 US9718790, I-1872 P2X purinoceptor 3 Homo sapiens 15.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265445 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265445&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945432 377004320 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505001 CC(C)Oc1ccc(cc1)\N=c1/[nH]c(=O)n(C[C@@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 183313 US9150546, I-483::US9688643, I-483::US9718790, I-0492 P2X purinoceptor 3 Homo sapiens 100.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183313 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183313&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578892 313634713 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505002 Cc1ccc(Cn2c(=O)n(CCC(O)=O)c(=O)[nH]\c2=N/c2ccc(OCC3CC3)cc2)cc1 InChI=1S/C24H26N4O5/c1-16-2-4-17(5-3-16)14-28-22(26-23(31)27(24(28)32)13-12-21(29)30)25-19-8-10-20(11-9-19)33-15-18-6-7-18/h2-5,8-11,18H,6-7,12-15H2,1H3,(H,29,30)(H,25,26,31) BRQJFTAWMXQPAQ-UHFFFAOYSA-N 265444 US9718790, I-1148::US9718790, I-1149 P2X purinoceptor 3 Homo sapiens 65.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265444 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265444&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278228 377004319 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505003 COC(=O)CCCCn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(Cl)c2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C26H31ClN4O5/c1-17(2)36-22-13-12-20(15-21(22)27)28-24-29-25(33)30(14-6-5-7-23(32)35-4)26(34)31(24)16-19-10-8-18(3)9-11-19/h8-13,15,17H,5-7,14,16H2,1-4H3,(H,28,29,33) ASJOGFYETZHUSY-UHFFFAOYSA-N 265448 US9718790, I-1873 P2X purinoceptor 3 Homo sapiens 2.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265448 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265448&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945418 377004322 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505004 CCOc1ccc(cc1)\N=c1/[nH]c(=O)n(C[C@@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 183314 US9150546, I-484::US9688643, I-484::US9718790, I-0493 P2X purinoceptor 3 Homo sapiens 290 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183314 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183314&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578830 313634714 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505005 C\C=C/c1ccc(Cn2c(=O)n(C[C@H](C)C(O)=O)c(=O)[nH]\c2=N/c2ccc(OC(C)C)cc2)cc1 265450 US9718790, I-1150 P2X purinoceptor 3 Homo sapiens 551 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265450 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265450&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278182 377004324 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505006 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(CCC(=O)NS(C)(=O)=O)c(=O)n1Cc1ccc(C)cc1 InChI=1S/C24H28ClN5O6S/c1-15(2)36-20-10-9-18(13-19(20)25)26-22-27-23(32)29(12-11-21(31)28-37(4,34)35)24(33)30(22)14-17-7-5-16(3)6-8-17/h5-10,13,15H,11-12,14H2,1-4H3,(H,28,31)(H,26,27,32) KSNQBJHFZLPENV-UHFFFAOYSA-N 265451 US9718790, I-1874 P2X purinoceptor 3 Homo sapiens 13.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265451 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265451&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019686 377004325 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505007 CCOc1ccc(cc1C)\N=c1/[nH]c(=O)n(C[C@@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 183315 US9150546, I-485::US9688643, I-485::US9718790, I-0494 P2X purinoceptor 3 Homo sapiens 198 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183315 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183315&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578794 313634715 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505008 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2cccc(SC)c2)n(Cc2ccc(Cl)cc2)c1=O 265453 US9718790, I-1151 P2X purinoceptor 3 Homo sapiens 46.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265453 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265453&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020874 377004327 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505009 CCc1nc2ccc(cc2s1)\N=c1/[nH]c(=O)n(CCC(=O)NS(C)(=O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C23H23ClN6O5S2/c1-3-20-26-17-9-8-16(12-18(17)36-20)25-21-27-22(32)29(11-10-19(31)28-37(2,34)35)23(33)30(21)13-14-4-6-15(24)7-5-14/h4-9,12H,3,10-11,13H2,1-2H3,(H,28,31)(H,25,27,32) RGEQKMHZTAOSSF-UHFFFAOYSA-N 265454 US9718790, I-1875 P2X purinoceptor 3 Homo sapiens 13.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265454 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265454&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019723 377004328 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505010 CC(C)Oc1ccc(cc1C)\N=c1/[nH]c(=O)n(C[C@@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 183316 US9150546, I-486::US9688643, I-486::US9718790, I-0495 P2X purinoceptor 3 Homo sapiens 42.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183316 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183316&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578773 313634716 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505011 CSc1cccc(c1)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 265456 US9718790, I-1152 P2X purinoceptor 3 Homo sapiens 110 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265456 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265456&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020848 377004330 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505012 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(CC(=O)NS(C)(=O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C22H23Cl2N5O6S/c1-13(2)35-18-9-8-16(10-17(18)24)25-20-26-21(31)29(12-19(30)27-36(3,33)34)22(32)28(20)11-14-4-6-15(23)7-5-14/h4-10,13H,11-12H2,1-3H3,(H,27,30)(H,25,26,31) OMWAJJVXDYTUST-UHFFFAOYSA-N 265457 US9718790, I-1876 P2X purinoceptor 3 Homo sapiens 35.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265457 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265457&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020290 377004331 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505013 CCOc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(C[C@@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 183317 US9150546, I-487::US9688643, I-487::US9718790, I-0496 P2X purinoceptor 3 Homo sapiens 27.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183317 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183317&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578939 313634717 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505014 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2cccc(SC)c2)n(Cc2ccc(C)cc2)c1=O 265459 US9718790, I-1153 P2X purinoceptor 3 Homo sapiens 71.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265459 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265459&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020849 377004333 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505015 OC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(F)cc3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H20ClFN4O5/c26-17-3-1-16(2-4-17)15-31-23(29-24(34)30(25(31)35)14-13-22(32)33)28-19-7-11-21(12-8-19)36-20-9-5-18(27)6-10-20/h1-12H,13-15H2,(H,32,33)(H,28,29,34) AFIPDQFCTAZBGV-UHFFFAOYSA-N 265460 US9718790, I-1877 P2X purinoceptor 3 Homo sapiens 36.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265460 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265460&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945325 377004334 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505016 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc3oc(C)nc3c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H24ClN5O5/c1-14-26-18-11-17(9-10-19(18)35-14)27-21-28-22(32)30(13-24(2,3)20(31)34-4)23(33)29(21)12-15-5-7-16(25)8-6-15/h5-11H,12-13H2,1-4H3,(H,27,28,32) BWWMLEAJMQPMGW-UHFFFAOYSA-N 183318 US9150546, I-488::US9688643, I-488::US9718790, I-0497 P2X purinoceptor 3 Homo sapiens 124 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183318 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183318&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578565 313634718 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505017 CSc1cccc(c1)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(C)cc1 265462 US9718790, I-1154 P2X purinoceptor 3 Homo sapiens 131 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265462 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265462&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020855 377004336 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505018 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(CCCCC(O)=O)c(=O)n1Cc1ccc(C)cc1 InChI=1S/C25H29ClN4O5/c1-16(2)35-21-12-11-19(14-20(21)26)27-23-28-24(33)29(13-5-4-6-22(31)32)25(34)30(23)15-18-9-7-17(3)8-10-18/h7-12,14,16H,4-6,13,15H2,1-3H3,(H,31,32)(H,27,28,33) WUERGSVWDUBJRQ-UHFFFAOYSA-N 265463 US9718790, I-1878 P2X purinoceptor 3 Homo sapiens 10.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265463 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265463&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278616 377004337 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505019 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc3oc(C)cc3c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H25ClN4O5/c1-15-11-17-12-19(9-10-20(17)35-15)27-22-28-23(32)30(14-25(2,3)21(31)34-4)24(33)29(22)13-16-5-7-18(26)8-6-16/h5-12H,13-14H2,1-4H3,(H,27,28,32) GYFNLPAGZFKNSP-UHFFFAOYSA-N 183319 US9150546, I-489::US9688643, I-489::US9718790, I-0498 P2X purinoceptor 3 Homo sapiens 10.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183319 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183319&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578659 313634719 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505020 CCOC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H29ClN4O5/c1-5-34-22(31)12-13-29-24(32)28-23(27-20-10-11-21(17(4)14-20)35-16(2)3)30(25(29)33)15-18-6-8-19(26)9-7-18/h6-11,14,16H,5,12-13,15H2,1-4H3,(H,27,28,32) RJKYBKHDALTXJO-UHFFFAOYSA-N 265465 US9718790, I-1155 P2X purinoceptor 3 Homo sapiens 9.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265465 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265465&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020866 377004339 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505021 COC(=O)c1cc(cn1C)\N=c1/[nH]c(=O)n(CCC(O)=O)c(=O)n1Cc1ccc(C)cc1 InChI=1S/C21H23N5O6/c1-13-4-6-14(7-5-13)11-26-19(22-15-10-16(18(29)32-3)24(2)12-15)23-20(30)25(21(26)31)9-8-17(27)28/h4-7,10,12H,8-9,11H2,1-3H3,(H,27,28)(H,22,23,30) VNQJVLAGIOKZIC-UHFFFAOYSA-N 265466 US9718790, I-1879 P2X purinoceptor 3 Homo sapiens 128 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265466 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265466&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020337 377004340 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505022 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(CN(C)C)c(Cl)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H29Cl2N5O4/c1-25(2,21(33)36-5)15-32-23(34)29-22(28-19-11-8-17(14-30(3)4)20(27)12-19)31(24(32)35)13-16-6-9-18(26)10-7-16/h6-12H,13-15H2,1-5H3,(H,28,29,34) XHHFQYQVSXWJKI-UHFFFAOYSA-N 183320 US9150546, I-490::US9688643, I-490::US9718790, I-0499 P2X purinoceptor 3 Homo sapiens 46.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183320 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183320&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578600 313634720 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506197 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ncccc3C(N)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H21ClN6O4/c1-2-30-23(33)29-22(31(24(30)34)14-15-5-7-16(25)8-6-15)28-17-9-11-18(12-10-17)35-21-19(20(26)32)4-3-13-27-21/h3-13H,2,14H2,1H3,(H2,26,32)(H,28,29,33) MZJZRNGTIDECND-UHFFFAOYSA-N 266631 US9718790, I-2365 P2X purinoceptor 3 Homo sapiens 211 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266631 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266631&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021151 377005502 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506198 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ncccc3C(O)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H20ClN5O5/c1-2-29-23(33)28-22(30(24(29)34)14-15-5-7-16(25)8-6-15)27-17-9-11-18(12-10-17)35-20-19(21(31)32)4-3-13-26-20/h3-13H,2,14H2,1H3,(H,31,32)(H,27,28,33) HZMOWRCSPXADQZ-UHFFFAOYSA-N 266632 US9718790, I-2366 P2X purinoceptor 3 Homo sapiens 90.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266632 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266632&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021150 377005503 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506199 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cc(C)nn3C)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H23ClN6O3/c1-4-29-22(31)26-21(30(23(29)32)14-16-5-7-17(24)8-6-16)25-18-9-11-19(12-10-18)33-20-13-15(2)27-28(20)3/h5-13H,4,14H2,1-3H3,(H,25,26,31) RZUUCWBYCJFSHV-UHFFFAOYSA-N 266633 US9718790, I-2367 P2X purinoceptor 3 Homo sapiens 128 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266633 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266633&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021198 377005504 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506200 Cc1cc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(C[C@H]3COC(C)(C)O3)c(=O)n2Cc2ccc(Cl)cc2)n(C)n1 266634 US9718790, I-2368 P2X purinoceptor 3 Homo sapiens 13.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266634 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266634&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020089 377005505 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506201 CC(CO)(CO)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccon3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H24ClN5O6/c1-24(14-31,15-32)13-30-22(33)27-21(29(23(30)34)12-16-2-4-17(25)5-3-16)26-18-6-8-19(9-7-18)36-20-10-11-35-28-20/h2-11,31-32H,12-15H2,1H3,(H,26,27,33) ATKFXYQEZLTIMT-UHFFFAOYSA-N 266635 US9718790, I-2369 P2X purinoceptor 3 Homo sapiens 3.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266635 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266635&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278403 377005506 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506202 OCC(O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccon3)cc2)n(Cc2ccc(Cl)cc2)c1=O 266636 US9718790, I-2370 P2X purinoceptor 3 Homo sapiens 11.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266636 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266636&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945375 377005507 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506203 Cc1cc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(C[C@H](O)CO)c(=O)n2Cc2ccc(Cl)cc2)n(C)n1 266637 US9718790, I-2371 P2X purinoceptor 3 Homo sapiens 102 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266637 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266637&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945440 377005508 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506204 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccnc(c3)C#N)cc2)n(Cc2ccc(Cl)cn2)c1=O InChI=1S/C23H18ClN7O3/c1-2-30-22(32)29-21(31(23(30)33)14-17-4-3-15(24)13-27-17)28-16-5-7-19(8-6-16)34-20-9-10-26-18(11-20)12-25/h3-11,13H,2,14H2,1H3,(H,28,29,32) FAXNPPBDERQIOZ-UHFFFAOYSA-N 266638 US9718790, I-2372 P2X purinoceptor 3 Homo sapiens 32.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266638 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266638&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945550 377005509 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506205 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(n3)C#N)cc2)n(Cc2ccc(Cl)cn2)c1=O InChI=1S/C23H18ClN7O3/c1-2-30-22(32)29-21(31(23(30)33)14-18-7-6-15(24)13-26-18)28-16-8-10-19(11-9-16)34-20-5-3-4-17(12-25)27-20/h3-11,13H,2,14H2,1H3,(H,28,29,32) XEIRGNMAJAAHJL-UHFFFAOYSA-N 266639 US9718790, I-2373 P2X purinoceptor 3 Homo sapiens 33.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266639 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266639&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019866 377005510 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506206 Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(n3)C#N)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H17ClN6O3/c1-29-22(31)28-21(30(23(29)32)14-15-5-7-16(24)8-6-15)27-17-9-11-19(12-10-17)33-20-4-2-3-18(13-25)26-20/h2-12H,14H2,1H3,(H,27,28,31) PTQCHRGZEFCBBV-UHFFFAOYSA-N 266640 US9718790, I-2374 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266640 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266640&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278404 377005511 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506207 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(nc3)C#N)cc2)n(Cc2ccc(Cl)cn2)c1=O InChI=1S/C23H18ClN7O3/c1-2-30-22(32)29-21(31(23(30)33)14-18-4-3-15(24)12-26-18)28-16-5-8-19(9-6-16)34-20-10-7-17(11-25)27-13-20/h3-10,12-13H,2,14H2,1H3,(H,28,29,32) KDXDNOVLNUKDTQ-UHFFFAOYSA-N 266641 US9718790, I-2375 P2X purinoceptor 3 Homo sapiens 22.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266641 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266641&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945412 377005512 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506208 Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cc(ccn3)C(N)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H19ClN6O4/c1-29-22(32)28-21(30(23(29)33)13-14-2-4-16(24)5-3-14)27-17-6-8-18(9-7-17)34-19-12-15(20(25)31)10-11-26-19/h2-12H,13H2,1H3,(H2,25,31)(H,27,28,32) DOLUZJAVKBCZNL-UHFFFAOYSA-N 266642 US9718790, I-2376 P2X purinoceptor 3 Homo sapiens 20.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266642 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266642&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019738 377005513 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506209 COC(=O)c1cc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(C)c(=O)n2Cc2ccc(Cl)cc2)ccn1 InChI=1S/C24H20ClN5O5/c1-29-23(32)28-22(30(24(29)33)14-15-3-5-16(25)6-4-15)27-17-7-9-18(10-8-17)35-19-11-12-26-20(13-19)21(31)34-2/h3-13H,14H2,1-2H3,(H,27,28,32) ZNBXHVIBVIUWLC-UHFFFAOYSA-N 266643 US9718790, I-2377 P2X purinoceptor 3 Homo sapiens 15.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266643 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266643&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945653 377005514 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506210 Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccnc(c3)C(N)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H19ClN6O4/c1-29-22(32)28-21(30(23(29)33)13-14-2-4-15(24)5-3-14)27-16-6-8-17(9-7-16)34-18-10-11-26-19(12-18)20(25)31/h2-12H,13H2,1H3,(H2,25,31)(H,27,28,32) CGCBIWIVBAENOM-UHFFFAOYSA-N 266644 US9718790, I-2378 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266644 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266644&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945517 377005515 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506211 Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(nn3)C(N)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C22H18ClN7O4/c1-29-21(32)26-20(30(22(29)33)12-13-2-4-14(23)5-3-13)25-15-6-8-16(9-7-15)34-18-11-10-17(19(24)31)27-28-18/h2-11H,12H2,1H3,(H2,24,31)(H,25,26,32) PPJAATIAKMRGRC-UHFFFAOYSA-N 266645 US9718790, I-2379 P2X purinoceptor 3 Homo sapiens 9.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266645 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266645&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945566 377005516 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506212 Cn1c(=O)[nH]\c(=N/c2ccc(Oc3nccc(n3)C(N)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C22H18ClN7O4/c1-29-21(32)28-19(30(22(29)33)12-13-2-4-14(23)5-3-13)26-15-6-8-16(9-7-15)34-20-25-11-10-17(27-20)18(24)31/h2-11H,12H2,1H3,(H2,24,31)(H,26,28,32) ZMIFZSXITVLDRV-UHFFFAOYSA-N 266646 US9718790, I-2380 P2X purinoceptor 3 Homo sapiens 29.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266646 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266646&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020359 377005517 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506213 Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(nn3)C(O)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C22H17ClN6O5/c1-28-21(32)25-20(29(22(28)33)12-13-2-4-14(23)5-3-13)24-15-6-8-16(9-7-15)34-18-11-10-17(19(30)31)26-27-18/h2-11H,12H2,1H3,(H,30,31)(H,24,25,32) VSKFHPYAOAEWCA-UHFFFAOYSA-N 266647 US9718790, I-2381 P2X purinoceptor 3 Homo sapiens 54.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266647 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266647&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278405 377005518 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506214 Cc1ccc(Cn2c(=O)n(C)c(=O)[nH]\c2=N/c2ccc(Oc3ccc(nn3)C(O)=O)cc2)cc1 InChI=1S/C23H20N6O5/c1-14-3-5-15(6-4-14)13-29-21(25-22(32)28(2)23(29)33)24-16-7-9-17(10-8-16)34-19-12-11-18(20(30)31)26-27-19/h3-12H,13H2,1-2H3,(H,30,31)(H,24,25,32) DBUXYTLAENZWRE-UHFFFAOYSA-N 266648 US9718790, I-2382 P2X purinoceptor 3 Homo sapiens 54.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266648 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266648&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020281 377005519 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506215 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(nn3)C(O)=O)cc2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C24H22N6O5/c1-3-29-23(33)26-22(30(24(29)34)14-16-6-4-15(2)5-7-16)25-17-8-10-18(11-9-17)35-20-13-12-19(21(31)32)27-28-20/h4-13H,3,14H2,1-2H3,(H,31,32)(H,25,26,33) QOWDUXMUXUXSFX-UHFFFAOYSA-N 266649 US9718790, I-2383 P2X purinoceptor 3 Homo sapiens 15.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266649 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266649&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020217 377005520 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506216 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cnc(cn3)C(O)=O)cc2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C24H22N6O5/c1-3-29-23(33)28-22(30(24(29)34)14-16-6-4-15(2)5-7-16)27-17-8-10-18(11-9-17)35-20-13-25-19(12-26-20)21(31)32/h4-13H,3,14H2,1-2H3,(H,31,32)(H,27,28,33) FUPPWZVVXNAALF-UHFFFAOYSA-N 266650 US9718790, I-2384 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266650 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266650&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020235 377005521 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506217 Cc1ccc(Cn2c(=O)n(C)c(=O)[nH]\c2=N/c2ccc(Oc3cnc(cn3)C(O)=O)cc2)cc1 InChI=1S/C23H20N6O5/c1-14-3-5-15(6-4-14)13-29-21(27-22(32)28(2)23(29)33)26-16-7-9-17(10-8-16)34-19-12-24-18(11-25-19)20(30)31/h3-12H,13H2,1-2H3,(H,30,31)(H,26,27,32) HWUMZHRJLFENQY-UHFFFAOYSA-N 266651 US9718790, I-2385 P2X purinoceptor 3 Homo sapiens 13.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266651 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266651&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945696 377005522 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506218 Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cnc(cn3)C(O)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C22H17ClN6O5/c1-28-21(32)27-20(29(22(28)33)12-13-2-4-14(23)5-3-13)26-15-6-8-16(9-7-15)34-18-11-24-17(10-25-18)19(30)31/h2-11H,12H2,1H3,(H,30,31)(H,26,27,32) AYQCTFSLFFCLPU-UHFFFAOYSA-N 266652 US9718790, I-2386 P2X purinoceptor 3 Homo sapiens 13.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266652 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266652&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278358 377005523 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506219 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(n3)C#N)c(OC)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H21ClN6O4/c1-3-31-24(33)30-23(32(25(31)34)15-16-7-9-17(26)10-8-16)29-18-11-12-20(21(13-18)35-2)36-22-6-4-5-19(14-27)28-22/h4-13H,3,15H2,1-2H3,(H,29,30,33) ZVNWRVBOUDGCLH-UHFFFAOYSA-N 266653 US9718790, I-2387 P2X purinoceptor 3 Homo sapiens 2.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266653 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266653&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945691 377005524 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506220 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cnc(cn3)C(N)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H20ClN7O4/c1-2-30-22(33)29-21(31(23(30)34)13-14-3-5-15(24)6-4-14)28-16-7-9-17(10-8-16)35-19-12-26-18(11-27-19)20(25)32/h3-12H,2,13H2,1H3,(H2,25,32)(H,28,29,33) QLZNGEZHYKYHHV-UHFFFAOYSA-N 266654 US9718790, I-2388 P2X purinoceptor 3 Homo sapiens 3.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266654 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266654&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020615 377005525 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506221 Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cnc(cn3)C(N)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C22H18ClN7O4/c1-29-21(32)28-20(30(22(29)33)12-13-2-4-14(23)5-3-13)27-15-6-8-16(9-7-15)34-18-11-25-17(10-26-18)19(24)31/h2-11H,12H2,1H3,(H2,24,31)(H,27,28,32) FUIDZQPAQJZGLW-UHFFFAOYSA-N 266655 US9718790, I-2389 P2X purinoceptor 3 Homo sapiens 10.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266655 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266655&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020563 377005526 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506222 COc1cc(ccc1Oc1cccc(n1)C#N)\N=c1/[nH]c(=O)n(C)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C24H19ClN6O4/c1-30-23(32)29-22(31(24(30)33)14-15-6-8-16(25)9-7-15)28-17-10-11-19(20(12-17)34-2)35-21-5-3-4-18(13-26)27-21/h3-12H,14H2,1-2H3,(H,28,29,32) PWVIMGXODHYUHV-UHFFFAOYSA-N 266656 US9718790, I-2390 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266656 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266656&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945727 377005527 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506223 Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cc(ccn3)C(O)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H18ClN5O5/c1-28-22(32)27-21(29(23(28)33)13-14-2-4-16(24)5-3-14)26-17-6-8-18(9-7-17)34-19-12-15(20(30)31)10-11-25-19/h2-12H,13H2,1H3,(H,30,31)(H,26,27,32) ASZCNURPTAUHCA-UHFFFAOYSA-N 266657 US9718790, I-2391 P2X purinoceptor 3 Homo sapiens 29.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266657 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266657&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020643 377005528 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506224 Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(cn3)C#N)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H17ClN6O3/c1-29-22(31)28-21(30(23(29)32)14-15-2-5-17(24)6-3-15)27-18-7-9-19(10-8-18)33-20-11-4-16(12-25)13-26-20/h2-11,13H,14H2,1H3,(H,27,28,31) JFMGMYXFDCOUBD-UHFFFAOYSA-N 266658 US9718790, I-2392 P2X purinoceptor 3 Homo sapiens 11.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266658 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266658&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945735 377005529 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506225 Cc1ccc(Cn2c(=O)n(C)c(=O)[nH]\c2=N/c2ccc(Oc3ccc(cn3)C#N)cc2)cc1 InChI=1S/C24H20N6O3/c1-16-3-5-17(6-4-16)15-30-22(28-23(31)29(2)24(30)32)27-19-8-10-20(11-9-19)33-21-12-7-18(13-25)14-26-21/h3-12,14H,15H2,1-2H3,(H,27,28,31) RWPANNMPWFMLKR-UHFFFAOYSA-N 266659 US9718790, I-2393 P2X purinoceptor 3 Homo sapiens 10.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266659 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266659&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278436 377005530 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506226 Fc1ccc(Cn2c(=O)n(CCCOC3CCCCO3)c(=O)[nH]\c2=N/c2ccc(Oc3ccon3)cc2)cc1 266660 US9718790, I-2394 P2X purinoceptor 3 Homo sapiens 21.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266660 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266660&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021187 377005531 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506227 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(cn3)C#N)cc2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C25H22N6O3/c1-3-30-24(32)29-23(31(25(30)33)16-18-6-4-17(2)5-7-18)28-20-9-11-21(12-10-20)34-22-13-8-19(14-26)15-27-22/h4-13,15H,3,16H2,1-2H3,(H,28,29,32) RJHZILVMVNOHNM-UHFFFAOYSA-N 266661 US9718790, I-2395 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266661 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266661&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278437 377005532 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506228 CC1(C)OCC(C)(Cn2c(=O)[nH]\c(=N/c3ccc(Oc4ccon4)cc3)n(Cc3ccc(F)cc3)c2=O)CO1 InChI=1S/C27H28FN5O6/c1-26(2)36-16-27(3,17-37-26)15-33-24(34)30-23(32(25(33)35)14-18-4-6-19(28)7-5-18)29-20-8-10-21(11-9-20)39-22-12-13-38-31-22/h4-13H,14-17H2,1-3H3,(H,29,30,34) HMGMQXGUGADYAH-UHFFFAOYSA-N 266662 US9718790, I-2396 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266662 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266662&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945574 377005533 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506229 OCCCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccon3)cc2)n(Cc2ccc(F)cc2)c1=O InChI=1S/C22H20FN5O5/c23-16-4-2-15(3-5-16)14-28-20(25-21(30)27(22(28)31)11-1-12-29)24-17-6-8-18(9-7-17)33-19-10-13-32-26-19/h2-10,13,29H,1,11-12,14H2,(H,24,25,30) UYPVXCBQNMUZTQ-UHFFFAOYSA-N 266663 US9718790, I-2397 P2X purinoceptor 3 Homo sapiens 39.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266663 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266663&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278661 377005534 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506230 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(cn3)C(N)=O)cc2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C25H24N6O4/c1-3-30-24(33)29-23(31(25(30)34)15-17-6-4-16(2)5-7-17)28-19-9-11-20(12-10-19)35-21-13-8-18(14-27-21)22(26)32/h4-14H,3,15H2,1-2H3,(H2,26,32)(H,28,29,33) PMBMDVRFXNESLL-UHFFFAOYSA-N 266664 US9718790, I-2398 P2X purinoceptor 3 Homo sapiens 3.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266664 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266664&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945736 377005535 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506231 CC(CO)(CO)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccon3)cc2)n(Cc2ccc(F)cc2)c1=O InChI=1S/C24H24FN5O6/c1-24(14-31,15-32)13-30-22(33)27-21(29(23(30)34)12-16-2-4-17(25)5-3-16)26-18-6-8-19(9-7-18)36-20-10-11-35-28-20/h2-11,31-32H,12-15H2,1H3,(H,26,27,33) CWLVETIERDTOOU-UHFFFAOYSA-N 266665 US9718790, I-2399 P2X purinoceptor 3 Homo sapiens 20.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266665 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266665&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278238 377005536 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506232 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(cn3)C(O)=O)cc2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C25H23N5O5/c1-3-29-24(33)28-23(30(25(29)34)15-17-6-4-16(2)5-7-17)27-19-9-11-20(12-10-19)35-21-13-8-18(14-26-21)22(31)32/h4-14H,3,15H2,1-2H3,(H,31,32)(H,27,28,33) QUDUHELYSMVWRA-UHFFFAOYSA-N 266666 US9718790, I-2400 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266666 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266666&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020022 377005537 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506233 Cc1ccc(Cn2c(=O)n(C)c(=O)[nH]\c2=N/c2ccc(Oc3ccc(cn3)C(O)=O)cc2)cc1 InChI=1S/C24H21N5O5/c1-15-3-5-16(6-4-15)14-29-22(27-23(32)28(2)24(29)33)26-18-8-10-19(11-9-18)34-20-12-7-17(13-25-20)21(30)31/h3-13H,14H2,1-2H3,(H,30,31)(H,26,27,32) FWFJTRSJHQLSDN-UHFFFAOYSA-N 266667 US9718790, I-2401 P2X purinoceptor 3 Homo sapiens 18.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266667 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266667&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020039 377005538 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506234 COC(=O)c1ccc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(C)c(=O)n2Cc2ccc(Cl)cc2)cn1 InChI=1S/C24H20ClN5O5/c1-29-23(32)28-22(30(24(29)33)14-15-3-5-16(25)6-4-15)27-17-7-9-18(10-8-17)35-19-11-12-20(26-13-19)21(31)34-2/h3-13H,14H2,1-2H3,(H,27,28,32) ZYVCCGXBJVRSKB-UHFFFAOYSA-N 266668 US9718790, I-2402 P2X purinoceptor 3 Homo sapiens 3.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266668 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266668&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020026 377005539 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506235 Cc1ccc(Cn2c(=O)n(C)c(=O)[nH]\c2=N/c2ccc(Oc3nccc(n3)C(O)=O)cc2)cc1 InChI=1S/C23H20N6O5/c1-14-3-5-15(6-4-14)13-29-20(27-22(32)28(2)23(29)33)25-16-7-9-17(10-8-16)34-21-24-12-11-18(26-21)19(30)31/h3-12H,13H2,1-2H3,(H,30,31)(H,25,27,32) YJKJTVGTUIZRIY-UHFFFAOYSA-N 266669 US9718790, I-2403 P2X purinoceptor 3 Homo sapiens 61.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266669 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266669&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020027 377005540 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506236 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3nccc(n3)C(O)=O)cc2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C24H22N6O5/c1-3-29-23(33)28-21(30(24(29)34)14-16-6-4-15(2)5-7-16)26-17-8-10-18(11-9-17)35-22-25-13-12-19(27-22)20(31)32/h4-13H,3,14H2,1-2H3,(H,31,32)(H,26,28,33) SZCFHKXDCAALSB-UHFFFAOYSA-N 266670 US9718790, I-2404 P2X purinoceptor 3 Homo sapiens 16.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266670 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266670&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020332 377005541 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506237 Cn1c(=O)[nH]\c(=N/c2ccc(Oc3nccc(n3)C(O)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C22H17ClN6O5/c1-28-21(32)27-19(29(22(28)33)12-13-2-4-14(23)5-3-13)25-15-6-8-16(9-7-15)34-20-24-11-10-17(26-20)18(30)31/h2-11H,12H2,1H3,(H,30,31)(H,25,27,32) UATOFTPDQBBCFR-UHFFFAOYSA-N 266671 US9718790, I-2405 P2X purinoceptor 3 Homo sapiens 62.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266671 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266671&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020238 377005542 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506238 Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(nc3)C(N)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H19ClN6O4/c1-29-22(32)28-21(30(23(29)33)13-14-2-4-15(24)5-3-14)27-16-6-8-17(9-7-16)34-18-10-11-19(20(25)31)26-12-18/h2-12H,13H2,1H3,(H2,25,31)(H,27,28,32) MLSRRJCBYIFHTA-UHFFFAOYSA-N 266672 US9718790, I-2406 P2X purinoceptor 3 Homo sapiens 10.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266672 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266672&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020240 377005543 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506239 Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(cn3)C(N)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H19ClN6O4/c1-29-22(32)28-21(30(23(29)33)13-14-2-5-16(24)6-3-14)27-17-7-9-18(10-8-17)34-19-11-4-15(12-26-19)20(25)31/h2-12H,13H2,1H3,(H2,25,31)(H,27,28,32) FMGMXFOFHHNBRL-UHFFFAOYSA-N 266673 US9718790, I-2407 P2X purinoceptor 3 Homo sapiens 9.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266673&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020343 377005544 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506240 OC[C@H](O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccon3)cc2)n(Cc2ccc(Cl)cc2)c1=O 266674 US9718790, I-2408 P2X purinoceptor 3 Homo sapiens 14.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266674 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266674&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945737 377005545 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506241 Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ncc(s3)C(O)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C21H16ClN5O5S/c1-26-19(30)25-18(27(21(26)31)11-12-2-4-13(22)5-3-12)24-14-6-8-15(9-7-14)32-20-23-10-16(33-20)17(28)29/h2-10H,11H2,1H3,(H,28,29)(H,24,25,30) NUONDJVSGYOLMJ-UHFFFAOYSA-N 266675 US9718790, I-2409 P2X purinoceptor 3 Homo sapiens 14.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266675 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266675&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021180 377005546 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506242 Cn1c(=O)[nH]\c(=N/c2ccc(Oc3nc(cs3)C(O)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C21H16ClN5O5S/c1-26-19(30)25-18(27(21(26)31)10-12-2-4-13(22)5-3-12)23-14-6-8-15(9-7-14)32-20-24-16(11-33-20)17(28)29/h2-9,11H,10H2,1H3,(H,28,29)(H,23,25,30) VICMCEDHOBFKOT-UHFFFAOYSA-N 266676 US9718790, I-2410 P2X purinoceptor 3 Homo sapiens 36.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266676 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266676&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021201 377005547 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506243 Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cc(n[nH]3)C(O)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C21H17ClN6O5/c1-27-20(31)24-19(28(21(27)32)11-12-2-4-13(22)5-3-12)23-14-6-8-15(9-7-14)33-17-10-16(18(29)30)25-26-17/h2-10H,11H2,1H3,(H,25,26)(H,29,30)(H,23,24,31) BBMQOAIMDYIHOY-UHFFFAOYSA-N 266677 US9718790, I-2411 P2X purinoceptor 3 Homo sapiens 166 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266677 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266677&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021178 377005548 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506244 Cn1ccc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(C[C@H](O)CO)c(=O)n2Cc2ccc(Cl)cc2)n1 266678 US9718790, I-2412 P2X purinoceptor 3 Homo sapiens 84.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266678 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266678&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021200 377005549 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506245 Cn1ccc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(CCCO)c(=O)n2Cc2ccc(Cl)cc2)n1 InChI=1S/C23H23ClN6O4/c1-28-13-11-20(27-28)34-19-9-7-18(8-10-19)25-21-26-22(32)29(12-2-14-31)23(33)30(21)15-16-3-5-17(24)6-4-16/h3-11,13,31H,2,12,14-15H2,1H3,(H,25,26,32) GUNIEDWRSLVRFE-UHFFFAOYSA-N 266679 US9718790, I-2413 P2X purinoceptor 3 Homo sapiens 36.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266679 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266679&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021202 377005550 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506246 Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ncc(s3)C(N)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C21H17ClN6O4S/c1-27-19(30)26-18(28(21(27)31)11-12-2-4-13(22)5-3-12)25-14-6-8-15(9-7-14)32-20-24-10-16(33-20)17(23)29/h2-10H,11H2,1H3,(H2,23,29)(H,25,26,30) LRXXTWZCINSHAP-UHFFFAOYSA-N 266680 US9718790, I-2414 P2X purinoceptor 3 Homo sapiens 3.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266680 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266680&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021190 377005551 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506247 Cn1c(=O)[nH]\c(=N/c2ccc(Oc3nc(cs3)C(N)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C21H17ClN6O4S/c1-27-19(30)26-18(28(21(27)31)10-12-2-4-13(22)5-3-12)24-14-6-8-15(9-7-14)32-20-25-16(11-33-20)17(23)29/h2-9,11H,10H2,1H3,(H2,23,29)(H,24,26,30) JIVIDYIPWZJUFQ-UHFFFAOYSA-N 266681 US9718790, I-2415 P2X purinoceptor 3 Homo sapiens 9.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266681 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266681&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021192 377005552 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506248 Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cc(n[nH]3)C(N)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C21H18ClN7O4/c1-28-20(31)25-19(29(21(28)32)11-12-2-4-13(22)5-3-12)24-14-6-8-15(9-7-14)33-17-10-16(18(23)30)26-27-17/h2-10H,11H2,1H3,(H2,23,30)(H,26,27)(H,24,25,31) ITHRPHUPGJJDIZ-UHFFFAOYSA-N 266682 US9718790, I-2416 P2X purinoceptor 3 Homo sapiens 54.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266682 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266682&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278367 377005553 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506249 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cc(n[nH]3)C(N)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C22H20ClN7O4/c1-2-29-21(32)26-20(30(22(29)33)12-13-3-5-14(23)6-4-13)25-15-7-9-16(10-8-15)34-18-11-17(19(24)31)27-28-18/h3-11H,2,12H2,1H3,(H2,24,31)(H,27,28)(H,25,26,32) JNQSICGQFVDUAX-UHFFFAOYSA-N 266683 US9718790, I-2417 P2X purinoceptor 3 Homo sapiens 41.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266683 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266683&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020272 377005554 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506250 OC[C@@H](O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ncccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O 266684 US9718790, I-2418 P2X purinoceptor 3 Homo sapiens 12.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266684 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266684&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020273 377005555 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506251 Clc1ccc(Cn2c(=O)n(CCOC3CCCCO3)c(=O)[nH]\c2=N/c2ccc(Oc3ncccn3)cc2)cc1 266685 US9718790, I-2419 P2X purinoceptor 3 Homo sapiens 3.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266685 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266685&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020328 377005556 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506252 OCCn1c(=O)[nH]\c(=N/c2ccc(Oc3cncc(F)c3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H19ClFN5O4/c24-16-3-1-15(2-4-16)14-30-21(28-22(32)29(9-10-31)23(30)33)27-18-5-7-19(8-6-18)34-20-11-17(25)12-26-13-20/h1-8,11-13,31H,9-10,14H2,(H,27,28,32) DIPMPCTVSUWNRK-UHFFFAOYSA-N 266686 US9718790, I-2420 P2X purinoceptor 3 Homo sapiens 9.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266686 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266686&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020344 377005557 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506253 Clc1ccc(Cn2c(=O)n(CCCOC3CCCCO3)c(=O)[nH]\c2=N/c2ccc(Oc3ncccn3)cc2)cc1 266687 US9718790, I-2421 P2X purinoceptor 3 Homo sapiens 3.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266687 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266687&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945738 377005558 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506254 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccnc(c3)C(O)=O)cc2)n(CC2CC[C@H](C)CC2)c1=O 266688 US9718790, I-2422 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266688 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266688&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020333 377005559 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506255 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(n3)C(O)=O)c(OC)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H22ClN5O6/c1-3-30-24(34)29-23(31(25(30)35)14-15-7-9-16(26)10-8-15)27-17-11-12-19(20(13-17)36-2)37-21-6-4-5-18(28-21)22(32)33/h4-13H,3,14H2,1-2H3,(H,32,33)(H,27,29,34) IEWVBXWHJQEILP-UHFFFAOYSA-N 266689 US9718790, I-2423 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266689 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266689&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020353 377005560 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506256 COc1cc(ccc1Oc1cccc(n1)C(O)=O)\N=c1/[nH]c(=O)n(C)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C24H20ClN5O6/c1-29-23(33)28-22(30(24(29)34)13-14-6-8-15(25)9-7-14)26-16-10-11-18(19(12-16)35-2)36-20-5-3-4-17(27-20)21(31)32/h3-12H,13H2,1-2H3,(H,31,32)(H,26,28,33) GIAKRNQLOUEYNK-UHFFFAOYSA-N 266690 US9718790, I-2424 P2X purinoceptor 3 Homo sapiens 20.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266690 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266690&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020042 377005561 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506257 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccnc(NC(=O)NC)c3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H24ClN7O4/c1-3-32-24(35)31-22(33(25(32)36)15-16-4-6-17(26)7-5-16)29-18-8-10-19(11-9-18)37-20-12-13-28-21(14-20)30-23(34)27-2/h4-14H,3,15H2,1-2H3,(H,29,31,35)(H2,27,28,30,34) JTVPHPNFXJYUGE-UHFFFAOYSA-N 266691 US9718790, I-2425 P2X purinoceptor 3 Homo sapiens 2.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266691 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266691&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020043 377005562 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506258 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(NC(=O)NC)nc3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H24ClN7O4/c1-3-32-24(35)31-22(33(25(32)36)15-16-4-6-17(26)7-5-16)29-18-8-10-19(11-9-18)37-20-12-13-21(28-14-20)30-23(34)27-2/h4-14H,3,15H2,1-2H3,(H,29,31,35)(H2,27,28,30,34) PMCLJZSNEXSLMJ-UHFFFAOYSA-N 266692 US9718790, I-2426 P2X purinoceptor 3 Homo sapiens 11.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266692 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266692&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945448 377005563 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506259 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cnc(cn3)C#N)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H18ClN7O3/c1-2-30-22(32)29-21(31(23(30)33)14-15-3-5-16(24)6-4-15)28-17-7-9-19(10-8-17)34-20-13-26-18(11-25)12-27-20/h3-10,12-13H,2,14H2,1H3,(H,28,29,32) ZVKPXQWKRYTPOA-UHFFFAOYSA-N 266693 US9718790, I-2427 P2X purinoceptor 3 Homo sapiens 2.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266693 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266693&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945458 377005564 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506260 Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cnc(cn3)C#N)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C22H16ClN7O3/c1-29-21(31)28-20(30(22(29)32)13-14-2-4-15(23)5-3-14)27-16-6-8-18(9-7-16)33-19-12-25-17(10-24)11-26-19/h2-9,11-12H,13H2,1H3,(H,27,28,31) BMEWIVCWKKVQLG-UHFFFAOYSA-N 266694 US9718790, I-2428 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266694 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266694&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278368 377005565 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506261 CC(=O)Nc1ccc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(C)c(=O)n2Cc2ccc(Cl)cc2)cn1 InChI=1S/C24H21ClN6O4/c1-15(32)27-21-12-11-20(13-26-21)35-19-9-7-18(8-10-19)28-22-29-23(33)30(2)24(34)31(22)14-16-3-5-17(25)6-4-16/h3-13H,14H2,1-2H3,(H,26,27,32)(H,28,29,33) VAONLPZTXJMFNA-UHFFFAOYSA-N 266695 US9718790, I-2429 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266695 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266695&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020066 377005566 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506262 CC(=O)Nc1cc(Oc2ccc(cc2)\N=c2/[nH]c(=O)[nH]c(=O)n2Cc2ccc(Cl)cc2)ccn1 InChI=1S/C23H19ClN6O4/c1-14(31)26-20-12-19(10-11-25-20)34-18-8-6-17(7-9-18)27-21-28-22(32)29-23(33)30(21)13-15-2-4-16(24)5-3-15/h2-12H,13H2,1H3,(H,25,26,31)(H2,27,28,29,32,33) GDHRSDQJQNWXCQ-UHFFFAOYSA-N 266696 US9718790, I-2430 P2X purinoceptor 3 Homo sapiens 48.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266696 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266696&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020092 377005567 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504534 CCCOc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(CC2(CC2)C(=O)OCC)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C26H28Cl2N4O5/c1-3-13-37-21-10-9-19(14-20(21)28)29-23-30-24(34)32(16-26(11-12-26)22(33)36-4-2)25(35)31(23)15-17-5-7-18(27)8-6-17/h5-10,14H,3-4,11-13,15-16H2,1-2H3,(H,29,30,34) RUPYRKXQFQAXHG-UHFFFAOYSA-N 264982 US9718790, I-0985 P2X purinoceptor 3 Homo sapiens 26.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264982 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264982&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020186 377003858 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504535 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc3oc(C)c(C)c3c2)n(Cc2ccc(Cl)cc2)c1=O 264983 US9718790, I-1650 P2X purinoceptor 3 Homo sapiens 9.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264983 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264983&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019788 377003859 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504536 OCCn1c(=O)nc(Nc2ccc(F)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C18H15ClF2N4O3/c19-12-3-1-11(2-4-12)10-25-16(22-13-5-6-14(20)15(21)9-13)23-17(27)24(7-8-26)18(25)28/h1-6,9,26H,7-8,10H2,(H,22,23,27) SPLPIBKXRGJGLE-UHFFFAOYSA-N 183158 US9150546, I-316::US9688643, I-316::US9718790, I-0316 P2X purinoceptor 3 Homo sapiens 712 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183158 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183158&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821214 313634558 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504537 CCCOc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(CC2(CC2)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C24H24Cl2N4O5/c1-2-11-35-19-8-7-17(12-18(19)26)27-21-28-22(33)30(14-24(9-10-24)20(31)32)23(34)29(21)13-15-3-5-16(25)6-4-15/h3-8,12H,2,9-11,13-14H2,1H3,(H,31,32)(H,27,28,33) QERFHMGEFGWSIE-UHFFFAOYSA-N 264985 US9718790, I-0986 P2X purinoceptor 3 Homo sapiens 31.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264985 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264985&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278477 377003861 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504538 OC(=O)CCn1c(=O)[nH]\c(=N/c2cccc(c2)S(F)(F)(F)(F)F)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C19H16ClF5N4O4S/c20-13-6-4-12(5-7-13)11-29-17(27-18(32)28(19(29)33)9-8-16(30)31)26-14-2-1-3-15(10-14)34(21,22,23,24)25/h1-7,10H,8-9,11H2,(H,30,31)(H,26,27,32) NHZRBCJIWBGPQG-UHFFFAOYSA-N 264986 US9718790, I-1651 P2X purinoceptor 3 Homo sapiens 54.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264986 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264986&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 88558798 377003862 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504539 CC(C)Oc1ccc(Nc2nc(=O)n(CCCN)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C22H25ClFN5O3/c1-14(2)32-19-9-8-17(12-18(19)24)26-20-27-21(30)28(11-3-10-25)22(31)29(20)13-15-4-6-16(23)7-5-15/h4-9,12,14H,3,10-11,13,25H2,1-2H3,(H,26,27,30) OIMNDBFRVLTWKG-UHFFFAOYSA-N 183159 US9150546, I-317::US9688643, I-317::US9718790, I-0317 P2X purinoceptor 3 Homo sapiens 137 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183159 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183159&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821352 313634559 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504540 CCOC(=O)C1(Cn2c(=O)[nH]\c(=N/c3ccc(OC(C)C)cc3)n(Cc3ccc(Cl)cc3)c2=O)CC1 InChI=1S/C26H29ClN4O5/c1-4-35-22(32)26(13-14-26)16-31-24(33)29-23(28-20-9-11-21(12-10-20)36-17(2)3)30(25(31)34)15-18-5-7-19(27)8-6-18/h5-12,17H,4,13-16H2,1-3H3,(H,28,29,33) CSNCFCHHBHVRHO-UHFFFAOYSA-N 264988 US9718790, I-0987 P2X purinoceptor 3 Homo sapiens 15.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264988 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264988&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278282 377003864 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504541 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc3oc(C)c(C)c3c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 264989 US9718790, I-1653 P2X purinoceptor 3 Homo sapiens 14.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264989 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264989&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020158 377003865 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504542 CC(C)Oc1ccc(Nc2nc(=O)n(CCO)c(=O)n2Cc2ccc(Cl)cc2)cc1 InChI=1S/C21H23ClN4O4/c1-14(2)30-18-9-7-17(8-10-18)23-19-24-20(28)25(11-12-27)21(29)26(19)13-15-3-5-16(22)6-4-15/h3-10,14,27H,11-13H2,1-2H3,(H,23,24,28) WNEKFDBSKZECEH-UHFFFAOYSA-N 183160 US9150546, I-320::US9688643, I-320::US9718790, I-0320 P2X purinoceptor 3 Homo sapiens 83.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183160 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183160&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821401 313634560 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504543 CC(C)Oc1ccc(cc1)\N=c1/[nH]c(=O)n(CC2(CC2)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C24H25ClN4O5/c1-15(2)34-19-9-7-18(8-10-19)26-21-27-22(32)29(14-24(11-12-24)20(30)31)23(33)28(21)13-16-3-5-17(25)6-4-16/h3-10,15H,11-14H2,1-2H3,(H,30,31)(H,26,27,32) HUWBEPUZWOELIE-UHFFFAOYSA-N 264991 US9718790, I-0988 P2X purinoceptor 3 Homo sapiens 93.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264991 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264991&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020797 377003867 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504544 CC(C)Oc1ccc(cc1C)\N=c1/[nH]c(=O)n(CC2CNC2)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C24H28ClN5O3/c1-15(2)33-21-9-8-20(10-16(21)3)27-22-28-23(31)30(14-18-11-26-12-18)24(32)29(22)13-17-4-6-19(25)7-5-17/h4-10,15,18,26H,11-14H2,1-3H3,(H,27,28,31) YQSSPXTXJWUOKJ-UHFFFAOYSA-N 264992 US9718790, I-1654 P2X purinoceptor 3 Homo sapiens 66.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264992 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264992&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020262 377003868 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504545 CCCOc1ccc(Nc2nc(=O)n(CCO)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C21H22ClFN4O4/c1-2-11-31-18-8-7-16(12-17(18)23)24-19-25-20(29)26(9-10-28)21(30)27(19)13-14-3-5-15(22)6-4-14/h3-8,12,28H,2,9-11,13H2,1H3,(H,24,25,29) IAXQCPJUCZINLK-UHFFFAOYSA-N 183161 US9150546, I-321::US9688643, I-321::US9718790, I-0321 P2X purinoceptor 3 Homo sapiens 33.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183161 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183161&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821099 313634561 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504546 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccc3)cc2)n(Cc2ccc(Cl)cc2)c1=O 264994 US9718790, I-0989 P2X purinoceptor 3 Homo sapiens 68.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264994 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264994&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 86689107 377003870 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504547 CC(C)Oc1ccc(Nc2nc(=O)c3ccc4cc(Cl)ccc4c3[nH]2)cc1 InChI=1S/C21H18ClN3O2/c1-12(2)27-16-7-5-15(6-8-16)23-21-24-19-17-10-4-14(22)11-13(17)3-9-18(19)20(26)25-21/h3-12H,1-2H3,(H2,23,24,25,26) HVPVVNIKYXYPFB-UHFFFAOYSA-N 264995 US9718790, I-1655 P2X purinoceptor 3 Homo sapiens 667 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264995 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264995&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 137528356 377003871 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504548 OCCn1c(=O)nc(Nc2ccc(OC3CCCC3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H25ClN4O4/c24-17-7-5-16(6-8-17)15-28-21(26-22(30)27(13-14-29)23(28)31)25-18-9-11-20(12-10-18)32-19-3-1-2-4-19/h5-12,19,29H,1-4,13-15H2,(H,25,26,30) QCYBCGKXTXODTF-UHFFFAOYSA-N 183162 US9150546, I-322::US9688643, I-322::US9718790, I-0322 P2X purinoceptor 3 Homo sapiens 112 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183162 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183162&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821323 313634562 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504549 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccc3)cc2)n(Cc2ccc(C)cc2)c1=O 264997 US9718790, I-0990 P2X purinoceptor 3 Homo sapiens 51.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264997 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264997&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945085 377003873 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504550 CCc1oc2ccc(cc2c1C)\N=c1/[nH]c(=O)n(CC(N)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C23H22ClN5O4/c1-3-18-13(2)17-10-16(8-9-19(17)33-18)26-21-27-22(31)29(12-20(25)30)23(32)28(21)11-14-4-6-15(24)7-5-14/h4-10H,3,11-12H2,1-2H3,(H2,25,30)(H,26,27,31) RAFODGAVOJGZBP-UHFFFAOYSA-N 264998 US9718790, I-1656 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264998 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264998&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020929 377003874 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504551 CC(C)COc1ccc(Nc2nc(=O)n(CCO)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C22H24ClFN4O4/c1-14(2)13-32-19-8-7-17(11-18(19)24)25-20-26-21(30)27(9-10-29)22(31)28(20)12-15-3-5-16(23)6-4-15/h3-8,11,14,29H,9-10,12-13H2,1-2H3,(H,25,26,30) DCGRXCWZDNUUBX-UHFFFAOYSA-N 183163 US9150546, I-323::US9688643, I-323::US9718790, I-0323 P2X purinoceptor 3 Homo sapiens 148 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183163 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183163&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821442 313634563 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504552 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccc3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 265000 US9718790, I-0991 P2X purinoceptor 3 Homo sapiens 22.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265000 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265000&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019804 377003876 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504553 CCc1oc2ccc(cc2c1C)\N=c1/[nH]c(=O)n(CC(=O)NC)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C24H24ClN5O4/c1-4-19-14(2)18-11-17(9-10-20(18)34-19)27-22-28-23(32)30(13-21(31)26-3)24(33)29(22)12-15-5-7-16(25)8-6-15/h5-11H,4,12-13H2,1-3H3,(H,26,31)(H,27,28,32) YBADZXTUZCOFQL-UHFFFAOYSA-N 265001 US9718790, I-1657 P2X purinoceptor 3 Homo sapiens 9.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265001 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265001&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020938 377003877 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504554 OCCn1c(=O)nc(Nc2ccc(OC3CCOCC3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H25ClN4O5/c24-17-3-1-16(2-4-17)15-28-21(26-22(30)27(11-12-29)23(28)31)25-18-5-7-19(8-6-18)33-20-9-13-32-14-10-20/h1-8,20,29H,9-15H2,(H,25,26,30) KUNJUWMHHWZXFE-UHFFFAOYSA-N 183164 US9150546, I-324::US9688643, I-324::US9718790, I-0324 P2X purinoceptor 3 Homo sapiens 309 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183164 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183164&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821216 313634564 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504555 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccc3)cc2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 265003 US9718790, I-0992 P2X purinoceptor 3 Homo sapiens 24.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265003 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265003&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019931 377003879 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504556 CCc1oc2ccc(cc2c1C)\N=c1/[nH]c(=O)n(CC(=O)NCCO)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C25H26ClN5O5/c1-3-20-15(2)19-12-18(8-9-21(19)36-20)28-23-29-24(34)31(14-22(33)27-10-11-32)25(35)30(23)13-16-4-6-17(26)7-5-16/h4-9,12,32H,3,10-11,13-14H2,1-2H3,(H,27,33)(H,28,29,34) IDQSKNHXUWIBRC-UHFFFAOYSA-N 265004 US9718790, I-1658 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265004 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265004&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020939 377003880 C04080 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504557 CC(C)Oc1ccc(Nc2nc(=O)n(CCO)c(=O)[nH]2)cc1F InChI=1S/C14H17FN4O4/c1-8(2)23-11-4-3-9(7-10(11)15)16-12-17-13(21)19(5-6-20)14(22)18-12/h3-4,7-8,20H,5-6H2,1-2H3,(H2,16,17,18,21,22) SIRUOEAXMZXYMV-UHFFFAOYSA-N 183165 US9150546, I-325::US9688643, I-325::US9718790, I-0325 P2X purinoceptor 3 Homo sapiens 665 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183165 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183165&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821351 313634565 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504558 COCO[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O)C(=O)OC 265006 US9718790, I-0993 P2X purinoceptor 3 Homo sapiens 20.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265006 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265006&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019932 377003882 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504559 Cc1nc2ccc(cc2s1)\N=c1/[nH]c(=O)n(CC(N)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C20H17ClN6O3S/c1-11-23-15-7-6-14(8-16(15)31-11)24-18-25-19(29)27(10-17(22)28)20(30)26(18)9-12-2-4-13(21)5-3-12/h2-8H,9-10H2,1H3,(H2,22,28)(H,24,25,29) VJQNNGGIMWTFMB-UHFFFAOYSA-N 265007 US9718790, I-1659 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265007 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265007&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020937 377003883 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504560 CC(C)Oc1ccc(Nc2nc(=O)n(CCCNC(C)=O)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C24H27ClFN5O4/c1-15(2)35-21-10-9-19(13-20(21)26)28-22-29-23(33)30(12-4-11-27-16(3)32)24(34)31(22)14-17-5-7-18(25)8-6-17/h5-10,13,15H,4,11-12,14H2,1-3H3,(H,27,32)(H,28,29,33) IFZZAWGUWRJMDO-UHFFFAOYSA-N 183166 US9150546, I-326::US9688643, I-326::US9718790, I-0326 P2X purinoceptor 3 Homo sapiens 11.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183166 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183166&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821044 313634566 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504561 COC(=O)[C@@H](O)Cn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O 265009 US9718790, I-0994 P2X purinoceptor 3 Homo sapiens 20.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265009 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265009&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019889 377003885 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504562 CNC(=O)Cn1c(=O)[nH]\c(=N/c2ccc3nc(C)sc3c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C21H19ClN6O3S/c1-12-24-16-8-7-15(9-17(16)32-12)25-19-26-20(30)28(11-18(29)23-2)21(31)27(19)10-13-3-5-14(22)6-4-13/h3-9H,10-11H2,1-2H3,(H,23,29)(H,25,26,30) LIBCWYQIYZGICR-UHFFFAOYSA-N 265010 US9718790, I-1660 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265010 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265010&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020940 377003886 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504563 CC(C)Cc1ccc(Nc2nc(=O)n(CCO)c(=O)n2Cc2ccc(Cl)cc2)cc1 InChI=1S/C22H25ClN4O3/c1-15(2)13-16-5-9-19(10-6-16)24-20-25-21(29)26(11-12-28)22(30)27(20)14-17-3-7-18(23)8-4-17/h3-10,15,28H,11-14H2,1-2H3,(H,24,25,29) JJEVCTBXYVKJGJ-UHFFFAOYSA-N 183167 US9150546, I-328::US9688643, I-328::US9718790, I-0328 P2X purinoceptor 3 Homo sapiens 124 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183167 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183167&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821364 313634567 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504564 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(C)c2)n(Cc2ccc(cc2)C(C)=C)c1=O 265012 US9718790, I-0995 P2X purinoceptor 3 Homo sapiens 276 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265012 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265012&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019890 377003888 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504565 Cc1nc2ccc(cc2s1)\N=c1/[nH]c(=O)n(CC(=O)NCCO)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C22H21ClN6O4S/c1-13-25-17-7-6-16(10-18(17)34-13)26-20-27-21(32)29(12-19(31)24-8-9-30)22(33)28(20)11-14-2-4-15(23)5-3-14/h2-7,10,30H,8-9,11-12H2,1H3,(H,24,31)(H,26,27,32) CXBOXXMINMPFKI-UHFFFAOYSA-N 265013 US9718790, I-1661 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265013 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265013&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945242 377003889 C04080 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504566 OCCn1c(=O)nc(Nc2ccc(OC(F)F)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C19H17ClF2N4O4/c20-13-3-1-12(2-4-13)11-26-17(24-18(28)25(9-10-27)19(26)29)23-14-5-7-15(8-6-14)30-16(21)22/h1-8,16,27H,9-11H2,(H,23,24,28) RKXQIFCQXRKXAA-UHFFFAOYSA-N 183168 US9150546, I-329::US9688643, I-329::US9718790, I-0329 P2X purinoceptor 3 Homo sapiens 266 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183168 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183168&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821162 313634568 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504567 COC(=O)C(=O)Cn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H25ClN4O6/c1-14(2)35-20-10-9-18(11-15(20)3)26-22-27-23(32)29(13-19(30)21(31)34-4)24(33)28(22)12-16-5-7-17(25)8-6-16/h5-11,14H,12-13H2,1-4H3,(H,26,27,32) FRKRIPAWPGSEAM-UHFFFAOYSA-N 265015 US9718790, I-0996 P2X purinoceptor 3 Homo sapiens 32.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265015 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265015&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019486 377003891 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504568 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cc(C)on3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 265016 US9718790, I-1662 P2X purinoceptor 3 Homo sapiens 11.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265016 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265016&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945491 377003892 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504569 OCCn1c(=O)nc(Nc2ccc(OCC#N)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C20H18ClN5O4/c21-15-3-1-14(2-4-15)13-26-18(24-19(28)25(10-11-27)20(26)29)23-16-5-7-17(8-6-16)30-12-9-22/h1-8,27H,10-13H2,(H,23,24,28) DAHFGHKKJUUEMZ-UHFFFAOYSA-N 183169 US9150546, I-330::US9688643, I-330::US9718790, I-0330 P2X purinoceptor 3 Homo sapiens 594 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183169 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183169&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821450 313634569 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504570 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(C)c2)n(Cc2ccc(cc2)C(C)C)c1=O 265018 US9718790, I-0997 P2X purinoceptor 3 Homo sapiens 680 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265018 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265018&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020484 377003894 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504571 CCc1nc2ccc(cc2s1)\N=c1/[nH]c(=O)n(CCO)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C21H20ClN5O3S/c1-2-18-24-16-8-7-15(11-17(16)31-18)23-19-25-20(29)26(9-10-28)21(30)27(19)12-13-3-5-14(22)6-4-13/h3-8,11,28H,2,9-10,12H2,1H3,(H,23,25,29) DBAPCJGRVQGMJI-UHFFFAOYSA-N 265019 US9718790, I-1663 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265019 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265019&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945477 377003895 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504572 CC(C)Oc1ccc(Nc2nc(=O)n(CC(C)(C)CN)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C24H29ClFN5O3/c1-15(2)34-20-10-9-18(11-19(20)26)28-21-29-22(32)31(14-24(3,4)13-27)23(33)30(21)12-16-5-7-17(25)8-6-16/h5-11,15H,12-14,27H2,1-4H3,(H,28,29,32) KNTGWOHWZKIFHC-UHFFFAOYSA-N 183170 US9150546, I-331::US9688643, I-331::US9718790, I-0331 P2X purinoceptor 3 Homo sapiens 66.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183170 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183170&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821383 313634570 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504573 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Cl)c(Cl)c2)n(Cc2ccc(C)cc2)c1=O 265021 US9718790, I-0998 P2X purinoceptor 3 Homo sapiens 24.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265021 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265021&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020487 377003897 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504574 CCc1nc2ccc(cc2s1)\N=c1/[nH]c(=O)n(C[C@H](C)NC(C)=O)c(=O)n1Cc1ccc(Cl)cc1 265022 US9718790, I-1665 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265022 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265022&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130279259 377003898 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504575 CC(C)Oc1ccc(Nc2nc(=O)n(CC(C)(C)CO)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C24H28ClFN4O4/c1-15(2)34-20-10-9-18(11-19(20)26)27-21-28-22(32)30(13-24(3,4)14-31)23(33)29(21)12-16-5-7-17(25)8-6-16/h5-11,15,31H,12-14H2,1-4H3,(H,27,28,32) HGRPNRICIGWDCD-UHFFFAOYSA-N 183171 US9150546, I-332::US9688643, I-332::US9718790, I-0332 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183171 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183171&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821434 313634571 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504576 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(OC(F)(F)F)cc2)n(Cc2ccc(C)cc2)c1=O 265024 US9718790, I-0999 P2X purinoceptor 3 Homo sapiens 174 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265024 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265024&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278482 377003900 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504577 CCc1oc2ccc(cc2c1C)\N=c1/[nH]c(=O)n(C[C@H](C)NC(C)=O)c(=O)n1Cc1ccc(Cl)cc1 265025 US9718790, I-1666 P2X purinoceptor 3 Homo sapiens 10.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265025 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265025&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019692 377003901 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504578 CC(C)Oc1ccc(Nc2nc(=O)n(CCO)c(=O)n2Cc2ccc(F)cc2)cc1F InChI=1S/C21H22F2N4O4/c1-13(2)31-18-8-7-16(11-17(18)23)24-19-25-20(29)26(9-10-28)21(30)27(19)12-14-3-5-15(22)6-4-14/h3-8,11,13,28H,9-10,12H2,1-2H3,(H,24,25,29) UKLFEXAABNFJMM-UHFFFAOYSA-N 183172 US9150546, I-333::US9688643, I-333::US9718790, I-0333 P2X purinoceptor 3 Homo sapiens 192 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183172 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183172&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821111 313634572 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504579 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Cl)c(c2)C(F)(F)F)n(Cc2ccc(C)cc2)c1=O 265027 US9718790, I-1000 P2X purinoceptor 3 Homo sapiens 116 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265027 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265027&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020442 377003903 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504580 COC(=O)CCn1c(=O)[nH]\c(=N/C2CCCCC2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C21H28N4O4/c1-15-8-10-16(11-9-15)14-25-19(22-17-6-4-3-5-7-17)23-20(27)24(21(25)28)13-12-18(26)29-2/h8-11,17H,3-7,12-14H2,1-2H3,(H,22,23,27) IKJJQCKTLKFTQP-UHFFFAOYSA-N 265028 US9718790, I-1668 P2X purinoceptor 3 Homo sapiens 309 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265028 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265028&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019681 377003904 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504581 OCCn1c(=O)nc(Nc2ccc(Oc3ccccc3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H21ClN4O4/c25-18-8-6-17(7-9-18)16-29-22(27-23(31)28(14-15-30)24(29)32)26-19-10-12-21(13-11-19)33-20-4-2-1-3-5-20/h1-13,30H,14-16H2,(H,26,27,31) KLZCINWURKWDQT-UHFFFAOYSA-N 183173 US9150546, I-334::US9688643, I-334::US9718790, I-0334 P2X purinoceptor 3 Homo sapiens 99.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183173 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183173&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76820945 313634573 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504582 CC(C)Oc1ccc(cc1C)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(cc1)C(C)=C 265030 US9718790, I-1001 P2X purinoceptor 3 Homo sapiens 292 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265030 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265030&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020976 377003906 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504583 Cc1nc2ccc(cc2s1)\N=c1/[nH]c(=O)n(CCC(N)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C21H19ClN6O3S/c1-12-24-16-7-6-15(10-17(16)32-12)25-19-26-20(30)27(9-8-18(23)29)21(31)28(19)11-13-2-4-14(22)5-3-13/h2-7,10H,8-9,11H2,1H3,(H2,23,29)(H,25,26,30) BREQRFOXMNTJTN-UHFFFAOYSA-N 265031 US9718790, I-1670 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265031 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265031&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019683 377003907 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504584 CC(C)Oc1ccc(Nc2nc(=O)n(CC3(CO)CC3)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C24H26ClFN4O4/c1-15(2)34-20-8-7-18(11-19(20)26)27-21-28-22(32)30(13-24(14-31)9-10-24)23(33)29(21)12-16-3-5-17(25)6-4-16/h3-8,11,15,31H,9-10,12-14H2,1-2H3,(H,27,28,32) NHPKSMZBRJQQSF-UHFFFAOYSA-N 183174 US9150546, I-335::US9688643, I-335::US9718790, I-0335 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183174 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183174&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821197 313634574 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504585 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(OC(F)(F)F)cc2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 265033 US9718790, I-1002 P2X purinoceptor 3 Homo sapiens 298 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265033 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265033&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020979 377003909 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504586 Cc1nc2ccc(cc2s1)\N=c1/[nH]c(=O)n(CCC(N)=O)c(=O)n1Cc1ccc(C)cc1 InChI=1S/C22H22N6O3S/c1-13-3-5-15(6-4-13)12-28-20(26-21(30)27(22(28)31)10-9-19(23)29)25-16-7-8-17-18(11-16)32-14(2)24-17/h3-8,11H,9-10,12H2,1-2H3,(H2,23,29)(H,25,26,30) ABQFYKZYQNETCR-UHFFFAOYSA-N 265034 US9718790, I-1671 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265034 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265034&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020945 377003910 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504587 COC(=O)Cn1c(=O)nc(Nc2ccc(OC(C)C)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C22H22ClFN4O5/c1-13(2)33-18-9-8-16(10-17(18)24)25-20-26-21(30)28(12-19(29)32-3)22(31)27(20)11-14-4-6-15(23)7-5-14/h4-10,13H,11-12H2,1-3H3,(H,25,26,30) FLNMUXWIGQAANO-UHFFFAOYSA-N 183175 US9150546, I-338::US9688643, I-338::US9718790, I-0338 P2X purinoceptor 3 Homo sapiens 53.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183175 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183175&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76820973 313634575 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504588 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Cl)c(c2)C(F)(F)F)n(Cc2ccc(C)cc2)c1=O)C(O)=O 265036 US9718790, I-1003 P2X purinoceptor 3 Homo sapiens 229 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265036 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265036&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020981 377003912 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504589 CCc1oc2ccc(cc2c1C)\N=c1/[nH]c(=O)n(C[C@@H](C)NC(C)=O)c(=O)n1Cc1ccc(Cl)cc1 265037 US9718790, I-1673 P2X purinoceptor 3 Homo sapiens 14.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265037 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265037&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020964 377003913 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504590 CC(C)Oc1ccc(Nc2nc(=O)n(CCO)c(=O)n2Cc2ccc(F)c(F)c2)cc1F InChI=1S/C21H21F3N4O4/c1-12(2)32-18-6-4-14(10-17(18)24)25-19-26-20(30)27(7-8-29)21(31)28(19)11-13-3-5-15(22)16(23)9-13/h3-6,9-10,12,29H,7-8,11H2,1-2H3,(H,25,26,30) CUQQYEWTZONCKB-UHFFFAOYSA-N 183176 US9150546, I-339::US9688643, I-339::US9718790, I-0339 P2X purinoceptor 3 Homo sapiens 775 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183176 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183176&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821332 313634576 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504591 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Cl)c(Cl)c2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 265039 US9718790, I-1004 P2X purinoceptor 3 Homo sapiens 85.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265039 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265039&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278547 377003915 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504592 Cc1ccc(Cn2\c(=N\c3nc4ccccc4s3)[nH]c(=O)n(CCC(O)=O)c2=O)cc1 InChI=1S/C21H19N5O4S/c1-13-6-8-14(9-7-13)12-26-18(23-19-22-15-4-2-3-5-16(15)31-19)24-20(29)25(21(26)30)11-10-17(27)28/h2-9H,10-12H2,1H3,(H,27,28)(H,22,23,24,29) MTYUXQBCTCHRAM-UHFFFAOYSA-N 265040 US9718790, I-1674 P2X purinoceptor 3 Homo sapiens 971 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265040 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265040&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020948 377003916 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504593 CC(C)Oc1ccc(Nc2nc(=O)n(CCO)c(=O)n2Cc2ccc(F)cc2F)cc1F InChI=1S/C21H21F3N4O4/c1-12(2)32-18-6-5-15(10-17(18)24)25-19-26-20(30)27(7-8-29)21(31)28(19)11-13-3-4-14(22)9-16(13)23/h3-6,9-10,12,29H,7-8,11H2,1-2H3,(H,25,26,30) RTZOYNJXYRFCMD-UHFFFAOYSA-N 183177 US9150546, I-340::US9688643, I-340::US9718790, I-0340 P2X purinoceptor 3 Homo sapiens 336 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183177 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183177&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821109 313634577 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504594 CCCCOc1ccc(cc1)\N=c1/[nH]c(=O)n(CC2(CC2)C(=O)OCC)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C27H31ClN4O5/c1-3-5-16-37-22-12-10-21(11-13-22)29-24-30-25(34)32(18-27(14-15-27)23(33)36-4-2)26(35)31(24)17-19-6-8-20(28)9-7-19/h6-13H,3-5,14-18H2,1-2H3,(H,29,30,34) KWQBLCDKDYBBHU-UHFFFAOYSA-N 265042 US9718790, I-1005 P2X purinoceptor 3 Homo sapiens 31.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265042 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265042&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020984 377003918 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504595 CCc1oc2ccc(cc2c1C)\N=c1/[nH]c(=O)n(CCC(O)=O)c(=O)n1CC1CC1 InChI=1S/C21H24N4O5/c1-3-16-12(2)15-10-14(6-7-17(15)30-16)22-19-23-20(28)24(9-8-18(26)27)21(29)25(19)11-13-4-5-13/h6-7,10,13H,3-5,8-9,11H2,1-2H3,(H,26,27)(H,22,23,28) RUKAUISMUZAZFK-UHFFFAOYSA-N 265043 US9718790, I-1676 P2X purinoceptor 3 Homo sapiens 854 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265043 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265043&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020159 377003919 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504596 CC(C)Oc1ccc(Nc2nc(=O)n(CCO)c(=O)n2Cc2ccc(Cl)c(F)c2)cc1F InChI=1S/C21H21ClF2N4O4/c1-12(2)32-18-6-4-14(10-17(18)24)25-19-26-20(30)27(7-8-29)21(31)28(19)11-13-3-5-15(22)16(23)9-13/h3-6,9-10,12,29H,7-8,11H2,1-2H3,(H,25,26,30) QSZIEXCHKXBPKQ-UHFFFAOYSA-N 183178 US9150546, I-341::US9688643, I-341::US9718790, I-0341 P2X purinoceptor 3 Homo sapiens 149 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183178 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183178&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821011 313634578 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504597 CCCCOc1ccc(cc1)\N=c1/[nH]c(=O)n(CC2(CC2)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C25H27ClN4O5/c1-2-3-14-35-20-10-8-19(9-11-20)27-22-28-23(33)30(16-25(12-13-25)21(31)32)24(34)29(22)15-17-4-6-18(26)7-5-17/h4-11H,2-3,12-16H2,1H3,(H,31,32)(H,27,28,33) AKHSVZATVYAZMO-UHFFFAOYSA-N 265045 US9718790, I-1006 P2X purinoceptor 3 Homo sapiens 118 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265045 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265045&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020228 377003921 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504598 CCOC(=O)CN1CC(Cn2c(=O)[nH]\c(=N/c3ccc(OC(C)C)c(C)c3)n(Cc3ccc(Cl)cc3)c2=O)C1 InChI=1S/C28H34ClN5O5/c1-5-38-25(35)17-32-13-21(14-32)16-34-27(36)31-26(30-23-10-11-24(19(4)12-23)39-18(2)3)33(28(34)37)15-20-6-8-22(29)9-7-20/h6-12,18,21H,5,13-17H2,1-4H3,(H,30,31,36) RNNRGPQNGKXBSF-UHFFFAOYSA-N 265046 US9718790, I-1677 P2X purinoceptor 3 Homo sapiens 17.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265046 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265046&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945391 377003922 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504599 CC(C)Oc1ccc(Nc2nc(=O)n(CCCOC3CCCCO3)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C27H32ClFN4O5/c1-18(2)38-23-12-11-21(16-22(23)29)30-25-31-26(34)32(13-5-15-37-24-6-3-4-14-36-24)27(35)33(25)17-19-7-9-20(28)10-8-19/h7-12,16,18,24H,3-6,13-15,17H2,1-2H3,(H,30,31,34) PZPBYNVUKMXYIV-UHFFFAOYSA-N 183179 US9150546, I-342::US9688643, I-342::US9718790, I-0342 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183179 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183179&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821045 313634579 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505023 CCOC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(C)c2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C26H32N4O5/c1-6-34-23(31)13-14-29-25(32)28-24(27-21-11-12-22(19(5)15-21)35-17(2)3)30(26(29)33)16-20-9-7-18(4)8-10-20/h7-12,15,17H,6,13-14,16H2,1-5H3,(H,27,28,32) UVESGNGSMVNFCZ-UHFFFAOYSA-N 265468 US9718790, I-1156 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265468 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265468&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020490 377004342 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505024 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(c3)C(=O)OC)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H23ClN4O5/c1-3-30-25(33)29-24(31(26(30)34)16-17-7-9-19(27)10-8-17)28-20-11-13-21(14-12-20)36-22-6-4-5-18(15-22)23(32)35-2/h4-15H,3,16H2,1-2H3,(H,28,29,33) HNFFUCOWBNPIDO-UHFFFAOYSA-N 265469 US9718790, I-1880 P2X purinoceptor 3 Homo sapiens 15.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265469 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265469&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020338 377004343 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505025 Cc1cc2cc(ccc2o1)\N=c1/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C24H23ClN4O5/c1-14-10-16-11-18(8-9-19(16)34-14)26-21-27-22(32)29(13-24(2,3)20(30)31)23(33)28(21)12-15-4-6-17(25)7-5-15/h4-11H,12-13H2,1-3H3,(H,30,31)(H,26,27,32) BDZSWGJDARTUHN-UHFFFAOYSA-N 183321 US9150546, I-491::US9688643, I-491::US9718790, I-0500 P2X purinoceptor 3 Homo sapiens 27.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183321 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183321&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578954 313634721 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505026 CC(C)Oc1ccc(cc1C)\N=c1/[nH]c(=O)n(CCC(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C23H25ClN4O5/c1-14(2)33-19-9-8-18(12-15(19)3)25-21-26-22(31)27(11-10-20(29)30)23(32)28(21)13-16-4-6-17(24)7-5-16/h4-9,12,14H,10-11,13H2,1-3H3,(H,29,30)(H,25,26,31) CGEBTLYJFVFFSS-UHFFFAOYSA-N 265471 US9718790, I-1157 P2X purinoceptor 3 Homo sapiens 52.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265471 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265471&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020428 377004345 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505027 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(c3)C(O)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H21ClN4O5/c1-2-29-24(33)28-23(30(25(29)34)15-16-6-8-18(26)9-7-16)27-19-10-12-20(13-11-19)35-21-5-3-4-17(14-21)22(31)32/h3-14H,2,15H2,1H3,(H,31,32)(H,27,28,33) QLAKDHBMJPTROD-UHFFFAOYSA-N 265472 US9718790, I-1881 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265472 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265472&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020475 377004346 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505028 CCn1ccc2cc(ccc12)\N=c1/[nH]c(=O)n(CC(C)(C)C(=O)OC)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C26H28ClN5O4/c1-5-30-13-12-18-14-20(10-11-21(18)30)28-23-29-24(34)32(16-26(2,3)22(33)36-4)25(35)31(23)15-17-6-8-19(27)9-7-17/h6-14H,5,15-16H2,1-4H3,(H,28,29,34) YGKBHZHTBZHKRV-UHFFFAOYSA-N 183322 US9150546, I-492::US9688643, I-492::US9718790, I-0501 P2X purinoceptor 3 Homo sapiens 102 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183322 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183322&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578940 313634722 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505029 CC(C)Oc1ccc(cc1C)\N=c1/[nH]c(=O)n(CCC(O)=O)c(=O)n1Cc1ccc(C)cc1 InChI=1S/C24H28N4O5/c1-15(2)33-20-10-9-19(13-17(20)4)25-22-26-23(31)27(12-11-21(29)30)24(32)28(22)14-18-7-5-16(3)6-8-18/h5-10,13,15H,11-12,14H2,1-4H3,(H,29,30)(H,25,26,31) OXIXYHYQAXHTDY-UHFFFAOYSA-N 265474 US9718790, I-1158 P2X purinoceptor 3 Homo sapiens 63.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265474 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265474&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020443 377004348 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505030 C[C@@H](Oc1ccc(cc1)\N=c1/[nH]c(=O)n(CC(CO)CO)c(=O)n1Cc1ccc(Cl)cc1)C(F)(F)F 265475 US9718790, I-1882 P2X purinoceptor 3 Homo sapiens 16.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265475 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265475&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020480 377004349 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505031 CCn1ccc2cc(ccc12)\N=c1/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C25H26ClN5O4/c1-4-29-12-11-17-13-19(9-10-20(17)29)27-22-28-23(34)31(15-25(2,3)21(32)33)24(35)30(22)14-16-5-7-18(26)8-6-16/h5-13H,4,14-15H2,1-3H3,(H,32,33)(H,27,28,34) JOBNQHGVFFAIKQ-UHFFFAOYSA-N 183323 US9150546, I-493::US9688643, I-493::US9718790, I-0502 P2X purinoceptor 3 Homo sapiens 952 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183323 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183323&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578622 313634723 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505032 COc1ccc(Cn2c(=O)n(C[C@H](C)C(O)=O)c(=O)[nH]\c2=N/c2ccc(OC(C)C)c(Cl)c2)cc1 265477 US9718790, I-1159 P2X purinoceptor 3 Homo sapiens 43.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265477 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265477&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019488 377004351 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505033 OC(=O)c1cc(Oc2ccc(cc2)\N=c2/[nH]c(=O)[nH]c(=O)n2Cc2ccc(Cl)cc2)ccn1 InChI=1S/C22H16ClN5O5/c23-14-3-1-13(2-4-14)12-28-20(26-21(31)27-22(28)32)25-15-5-7-16(8-6-15)33-17-9-10-24-18(11-17)19(29)30/h1-11H,12H2,(H,29,30)(H2,25,26,27,31,32) ZIOYXEKVMVEAGK-UHFFFAOYSA-N 265478 US9718790, I-1883 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265478 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265478&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278573 377004352 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505034 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc3nc(C)oc3c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H24ClN5O5/c1-14-26-18-10-9-17(11-19(18)35-14)27-21-28-22(32)30(13-24(2,3)20(31)34-4)23(33)29(21)12-15-5-7-16(25)8-6-15/h5-11H,12-13H2,1-4H3,(H,27,28,32) DERUTLWVSXYUBL-UHFFFAOYSA-N 183324 US9150546, I-494::US9688643, I-494::US9718790, I-0503 P2X purinoceptor 3 Homo sapiens 34.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183324 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183324&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578858 313634724 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505035 C\C=C\c1ccc(Cn2c(=O)n(C[C@H](C)C(O)=O)c(=O)[nH]\c2=N/c2ccc(OC(C)C)cc2)cc1 265480 US9718790, I-1160 P2X purinoceptor 3 Homo sapiens 973 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265480 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265480&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945073 377004354 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505036 CCOC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(F)c2)n(CC2CCC(F)(F)CC2)c1=O InChI=1S/C24H31F3N4O5/c1-4-35-20(32)9-12-30-22(33)29-21(28-17-5-6-19(18(25)13-17)36-15(2)3)31(23(30)34)14-16-7-10-24(26,27)11-8-16/h5-6,13,15-16H,4,7-12,14H2,1-3H3,(H,28,29,33) LVSDCJJSYVXUTM-UHFFFAOYSA-N 265481 US9718790, I-1884 P2X purinoceptor 3 Homo sapiens 296 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265481 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265481&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278574 377004355 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505037 CN(C)Cc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C24H27Cl2N5O4/c1-24(2,20(32)33)14-31-22(34)28-21(27-18-10-7-16(13-29(3)4)19(26)11-18)30(23(31)35)12-15-5-8-17(25)9-6-15/h5-11H,12-14H2,1-4H3,(H,32,33)(H,27,28,34) CQRVXUVYPUKGAY-UHFFFAOYSA-N 183325 US9150546, I-495::US9688643, I-495::US9718790, I-0504 P2X purinoceptor 3 Homo sapiens 125 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183325 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183325&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578874 313634725 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505038 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(OC(F)F)cc2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 265483 US9718790, I-1161 P2X purinoceptor 3 Homo sapiens 148 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265483 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265483&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020423 377004357 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505039 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cncc(c3)C(O)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H20ClN5O5/c1-2-29-23(33)28-22(30(24(29)34)14-15-3-5-17(25)6-4-15)27-18-7-9-19(10-8-18)35-20-11-16(21(31)32)12-26-13-20/h3-13H,2,14H2,1H3,(H,31,32)(H,27,28,33) RCKAIDRZCRYEJO-UHFFFAOYSA-N 265484 US9718790, I-1885 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265484 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265484&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945593 377004358 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505040 Cc1nc2ccc(cc2o1)\N=c1/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C23H22ClN5O5/c1-13-25-17-9-8-16(10-18(17)34-13)26-20-27-21(32)29(12-23(2,3)19(30)31)22(33)28(20)11-14-4-6-15(24)7-5-14/h4-10H,11-12H2,1-3H3,(H,30,31)(H,26,27,32) MDIBYOPAIJSTAN-UHFFFAOYSA-N 183326 US9150546, I-496::US9688643, I-496::US9718790, I-0505 P2X purinoceptor 3 Homo sapiens 125 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183326 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183326&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578848 313634726 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505041 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(OC(F)F)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 265486 US9718790, I-1162 P2X purinoceptor 3 Homo sapiens 179 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265486 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265486&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020425 377004360 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505042 CCOc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(CC2COC(C)(C)OC2)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C25H28Cl2N4O5/c1-4-34-21-10-9-19(11-20(21)27)28-22-29-23(32)31(13-17-14-35-25(2,3)36-15-17)24(33)30(22)12-16-5-7-18(26)8-6-16/h5-11,17H,4,12-15H2,1-3H3,(H,28,29,32) QRUOOLUMNZAGMS-UHFFFAOYSA-N 265487 US9718790, I-1886 P2X purinoceptor 3 Homo sapiens 3.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265487 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265487&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945554 377004361 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505043 Cc1nc2cc(ccc2o1)\N=c1/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C23H22ClN5O5/c1-13-25-17-10-16(8-9-18(17)34-13)26-20-27-21(32)29(12-23(2,3)19(30)31)22(33)28(20)11-14-4-6-15(24)7-5-14/h4-10H,11-12H2,1-3H3,(H,30,31)(H,26,27,32) QXSSRYCKGNMWJG-UHFFFAOYSA-N 183327 US9150546, I-497::US9688643, I-497::US9718790, I-0506 P2X purinoceptor 3 Homo sapiens 458 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183327 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183327&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578615 313634727 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505044 CC(C)Oc1ccc(cc1C)\N=c1/[nH]c(=O)n([C@H](C)[C@@H](C)C(=O)N[C@H](C)[C@@H](O)c2ccccc2)c(=O)n1Cc1ccc(Cl)cc1 265489 US9718790, I-1163 P2X purinoceptor 3 Homo sapiens 823 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265489 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265489&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278308 377004363 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505045 CCOc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(C[C@H]2COC(C)(C)O2)c(=O)n1Cc1ccc(Cl)cc1 265490 US9718790, I-1887 P2X purinoceptor 3 Homo sapiens 3.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265490 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265490&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020040 377004364 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505046 CCOC(=O)CCCn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(Cl)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H28Cl2N4O5/c1-4-35-22(32)6-5-13-30-24(33)29-23(28-19-11-12-21(20(27)14-19)36-16(2)3)31(25(30)34)15-17-7-9-18(26)10-8-17/h7-12,14,16H,4-6,13,15H2,1-3H3,(H,28,29,33) RZCZZXLNXHRKPV-UHFFFAOYSA-N 183328 US9150546, I-498::US9688643, I-498::US9718790, I-0507 P2X purinoceptor 3 Homo sapiens 9.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183328 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183328&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578625 313634728 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505047 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(OC(F)F)cc2)n(Cc2ccc(Cl)cc2)c1=O 265492 US9718790, I-1166 P2X purinoceptor 3 Homo sapiens 126 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265492 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265492&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019717 377004366 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505048 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cc(O)ncn3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C22H19ClN6O4/c1-2-28-21(31)27-20(29(22(28)32)12-14-3-5-15(23)6-4-14)26-16-7-9-17(10-8-16)33-19-11-18(30)24-13-25-19/h3-11,13H,2,12H2,1H3,(H,24,25,30)(H,26,27,31) KEWDMRXLJKBSEM-UHFFFAOYSA-N 265493 US9718790, I-1888 P2X purinoceptor 3 Homo sapiens 10.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265493 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265493&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945576 377004367 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505049 CC(C)Oc1ccc(cc1C)\N=c1/[nH]c(=O)[nH]c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C20H21ClN4O3/c1-12(2)28-17-9-8-16(10-13(17)3)22-18-23-19(26)24-20(27)25(18)11-14-4-6-15(21)7-5-14/h4-10,12H,11H2,1-3H3,(H2,22,23,24,26,27) BISBPWAYYOPSQX-UHFFFAOYSA-N 183329 US9150546, I-499::US9688643, I-499::US9718790, I-0508 P2X purinoceptor 3 Homo sapiens 137 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183329 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183329&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578699 313634729 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505050 CCOC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(Br)c2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C25H29BrN4O5/c1-5-34-22(31)12-13-29-24(32)28-23(27-19-10-11-21(20(26)14-19)35-16(2)3)30(25(29)33)15-18-8-6-17(4)7-9-18/h6-11,14,16H,5,12-13,15H2,1-4H3,(H,27,28,32) MAHIYKUGJKINHM-UHFFFAOYSA-N 265495 US9718790, I-1168 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265495 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265495&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117756604 377004369 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505051 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(CC(=O)OC)c3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C27H25ClN4O5/c1-3-31-26(34)30-25(32(27(31)35)17-18-7-9-20(28)10-8-18)29-21-11-13-22(14-12-21)37-23-6-4-5-19(15-23)16-24(33)36-2/h4-15H,3,16-17H2,1-2H3,(H,29,30,34) GWSVIQKAPSHZFP-UHFFFAOYSA-N 265496 US9718790, I-1889 P2X purinoceptor 3 Homo sapiens 23.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265496 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265496&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945429 377004370 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505052 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(CCCC(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C23H24Cl2N4O5/c1-14(2)34-19-10-9-17(12-18(19)25)26-21-27-22(32)28(11-3-4-20(30)31)23(33)29(21)13-15-5-7-16(24)8-6-15/h5-10,12,14H,3-4,11,13H2,1-2H3,(H,30,31)(H,26,27,32) WCZMIXQUMLQDCK-UHFFFAOYSA-N 183330 US9150546, I-500::US9688643, I-500::US9718790, I-0509 P2X purinoceptor 3 Homo sapiens 13.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183330 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183330&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578791 313634730 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505053 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(C=C(C)C)c(F)c2)n(Cc2ccc(C)cc2)c1=O 265498 US9718790, I-1171 P2X purinoceptor 3 Homo sapiens 25.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265498 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265498&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021064 377004372 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505054 COC(=O)CCn1c(=O)[nH]\c(=N/c2ccccc2NC(C)=O)n(Cc2ccc(C)cc2)c1=O InChI=1S/C23H25N5O5/c1-15-8-10-17(11-9-15)14-28-21(25-19-7-5-4-6-18(19)24-16(2)29)26-22(31)27(23(28)32)13-12-20(30)33-3/h4-11H,12-14H2,1-3H3,(H,24,29)(H,25,26,31) QGNIPTQBGUQOBC-UHFFFAOYSA-N 265499 US9718790, I-1892 P2X purinoceptor 3 Homo sapiens 113 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265499 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265499&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019984 377004373 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505055 Cc1cc2cc(ccc2o1)\N=c1/[nH]c(=O)[nH]c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C19H15ClN4O3/c1-11-8-13-9-15(6-7-16(13)27-11)21-17-22-18(25)23-19(26)24(17)10-12-2-4-14(20)5-3-12/h2-9H,10H2,1H3,(H2,21,22,23,25,26) LINZAOUDZMSNFJ-UHFFFAOYSA-N 183331 US9150546, I-501::US9688643, I-501::US9718790, I-0510 P2X purinoceptor 3 Homo sapiens 191 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183331 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183331&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578605 313634731 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505056 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(CN(C)C)c(Cl)c2)n(Cc2ccc(C)cc2)c1=O 265501 US9718790, I-1172 P2X purinoceptor 3 Homo sapiens 97.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265501 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265501&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945295 377004375 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505057 COC(=O)CCn1c(=O)[nH]\c(=N/c2cc(c[nH]c2=O)-c2ccncc2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C25H24N6O5/c1-16-3-5-17(6-4-16)15-31-23(29-24(34)30(25(31)35)12-9-21(32)36-2)28-20-13-19(14-27-22(20)33)18-7-10-26-11-8-18/h3-8,10-11,13-14H,9,12,15H2,1-2H3,(H,27,33)(H,28,29,34) MWGCMROXBCCDIW-UHFFFAOYSA-N 265502 US9718790, I-1893 P2X purinoceptor 3 Homo sapiens 178 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265502 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265502&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 135121008 377004376 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505058 CCOC(=O)CCCn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H31ClN4O5/c1-5-35-23(32)7-6-14-30-25(33)29-24(28-21-12-13-22(18(4)15-21)36-17(2)3)31(26(30)34)16-19-8-10-20(27)11-9-19/h8-13,15,17H,5-7,14,16H2,1-4H3,(H,28,29,33) CHEHAKBBCUEQJD-UHFFFAOYSA-N 183332 US9150546, I-502::US9688643, I-502::US9718790, I-0511 P2X purinoceptor 3 Homo sapiens 20.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183332 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183332&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578821 313634732 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505059 CCOc1ccc(cc1Br)\N=c1/[nH]c(=O)n(C[C@H](C)C(=O)OC)c(=O)n1Cc1ccc(C)cc1 265504 US9718790, I-1173 P2X purinoceptor 3 Homo sapiens 9.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265504 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265504&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021066 377004378 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505060 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(CC(O)=O)c3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H23ClN4O5/c1-2-30-25(34)29-24(31(26(30)35)16-17-6-8-19(27)9-7-17)28-20-10-12-21(13-11-20)36-22-5-3-4-18(14-22)15-23(32)33/h3-14H,2,15-16H2,1H3,(H,32,33)(H,28,29,34) LMCPMMUNPDXHEH-UHFFFAOYSA-N 265505 US9718790, I-1894 P2X purinoceptor 3 Homo sapiens 23.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265505 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265505&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019967 377004379 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505061 CC(C)Oc1ccc(cc1C)\N=c1/[nH]c(=O)n(CCCC(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C24H27ClN4O5/c1-15(2)34-20-11-10-19(13-16(20)3)26-22-27-23(32)28(12-4-5-21(30)31)24(33)29(22)14-17-6-8-18(25)9-7-17/h6-11,13,15H,4-5,12,14H2,1-3H3,(H,30,31)(H,26,27,32) BXLWUDHFHPTRAG-UHFFFAOYSA-N 183333 US9150546, I-503::US9688643, I-503::US9718790, I-0512 P2X purinoceptor 3 Homo sapiens 50.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183333 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183333&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578619 313634733 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505062 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(C=C(C)C)c(F)c2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 265507 US9718790, I-1174 P2X purinoceptor 3 Homo sapiens 27.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265507 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265507&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021046 377004381 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505063 NC(=O)c1cc(Oc2ccc(cc2)\N=c2/[nH]c(=O)[nH]c(=O)n2Cc2ccc(Cl)cc2)ccn1 InChI=1S/C22H17ClN6O4/c23-14-3-1-13(2-4-14)12-29-20(27-21(31)28-22(29)32)26-15-5-7-16(8-6-15)33-17-9-10-25-18(11-17)19(24)30/h1-11H,12H2,(H2,24,30)(H2,26,27,28,31,32) DVPIVHDSLPCUBK-UHFFFAOYSA-N 265508 US9718790, I-1896 P2X purinoceptor 3 Homo sapiens 14.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265508 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265508&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945567 377004382 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505064 CCOC(=O)CCCn1c(=O)[nH]\c(=N/c2ccc3oc(C)cc3c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H25ClN4O5/c1-3-34-22(31)5-4-12-29-24(32)28-23(27-20-10-11-21-18(14-20)13-16(2)35-21)30(25(29)33)15-17-6-8-19(26)9-7-17/h6-11,13-14H,3-5,12,15H2,1-2H3,(H,27,28,32) NRMCIFMJBUNITC-UHFFFAOYSA-N 183334 US9150546, I-504::US9688643, I-504::US9718790, I-0513 P2X purinoceptor 3 Homo sapiens 15.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183334 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183334&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578890 313634734 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505066 OCCNC(=O)c1cc(Oc2ccc(cc2)\N=c2/[nH]c(=O)[nH]c(=O)n2Cc2ccc(Cl)cc2)ccn1 InChI=1S/C24H21ClN6O5/c25-16-3-1-15(2-4-16)14-31-22(29-23(34)30-24(31)35)28-17-5-7-18(8-6-17)36-19-9-10-26-20(13-19)21(33)27-11-12-32/h1-10,13,32H,11-12,14H2,(H,27,33)(H2,28,29,30,34,35) HOMQZEAGFFIICL-UHFFFAOYSA-N 265510 US9718790, I-1897 P2X purinoceptor 3 Homo sapiens 24.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265510 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265510&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945261 377004384 C04080 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505067 Cc1cc2cc(ccc2o1)\N=c1/[nH]c(=O)n(CCCC(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C23H21ClN4O5/c1-14-11-16-12-18(8-9-19(16)33-14)25-21-26-22(31)27(10-2-3-20(29)30)23(32)28(21)13-15-4-6-17(24)7-5-15/h4-9,11-12H,2-3,10,13H2,1H3,(H,29,30)(H,25,26,31) SPZUYZIZNIODLC-UHFFFAOYSA-N 183335 US9150546, I-505::US9688643, I-505::US9718790, I-0514 P2X purinoceptor 3 Homo sapiens 120 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183335 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183335&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578831 313634735 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505069 FC(F)(F)CNC(=O)c1cc(Oc2ccc(cc2)\N=c2/[nH]c(=O)[nH]c(=O)n2Cc2ccc(Cl)cc2)ccn1 InChI=1S/C24H18ClF3N6O4/c25-15-3-1-14(2-4-15)12-34-21(32-22(36)33-23(34)37)31-16-5-7-17(8-6-16)38-18-9-10-29-19(11-18)20(35)30-13-24(26,27)28/h1-11H,12-13H2,(H,30,35)(H2,31,32,33,36,37) NGFQWSLZHYMVIZ-UHFFFAOYSA-N 265512 US9718790, I-1898 P2X purinoceptor 3 Homo sapiens 11.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265512 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265512&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278382 377004386 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505070 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc3n(CC(C)C)ccc3c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C28H32ClN5O4/c1-18(2)15-32-13-12-20-14-22(10-11-23(20)32)30-25-31-26(36)34(17-28(3,4)24(35)38-5)27(37)33(25)16-19-6-8-21(29)9-7-19/h6-14,18H,15-17H2,1-5H3,(H,30,31,36) YVYTXXAKCRMLAS-UHFFFAOYSA-N 183336 US9150546, I-506::US9688643, I-506::US9718790, I-0515 P2X purinoceptor 3 Homo sapiens 279 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183336 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183336&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578514 313634736 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505071 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(CN(C)C)c(Cl)c2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 265514 US9718790, I-1177 P2X purinoceptor 3 Homo sapiens 273 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265514 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265514&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278310 377004388 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505072 CC(C)Oc1ccc(cc1C)\N=c1/[nH]c(=O)n(CC2COC(C)(C)OC2)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C27H33ClN4O5/c1-17(2)37-23-11-10-22(12-18(23)3)29-24-30-25(33)32(14-20-15-35-27(4,5)36-16-20)26(34)31(24)13-19-6-8-21(28)9-7-19/h6-12,17,20H,13-16H2,1-5H3,(H,29,30,33) OCBZAIDRBZHNSX-UHFFFAOYSA-N 265515 US9718790, I-1899 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265515 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265515&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019744 377004389 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505073 CCCn1ccc2cc(ccc12)\N=c1/[nH]c(=O)n(CC(C)(C)C(=O)OC)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C27H30ClN5O4/c1-5-13-31-14-12-19-15-21(10-11-22(19)31)29-24-30-25(35)33(17-27(2,3)23(34)37-4)26(36)32(24)16-18-6-8-20(28)9-7-18/h6-12,14-15H,5,13,16-17H2,1-4H3,(H,29,30,35) CZJPRYZTVINBPE-UHFFFAOYSA-N 183337 US9150546, I-507::US9688643, I-507::US9718790, I-0516 P2X purinoceptor 3 Homo sapiens 301 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183337 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183337&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578496 313634737 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505074 CC(C)Oc1ccc(cc1Br)\N=c1/[nH]c(=O)n(CCC(O)=O)c(=O)n1Cc1ccc(C)cc1 InChI=1S/C23H25BrN4O5/c1-14(2)33-19-9-8-17(12-18(19)24)25-21-26-22(31)27(11-10-20(29)30)23(32)28(21)13-16-6-4-15(3)5-7-16/h4-9,12,14H,10-11,13H2,1-3H3,(H,29,30)(H,25,26,31) ZYXNSRYLSGRNHT-UHFFFAOYSA-N 265517 US9718790, I-1178 P2X purinoceptor 3 Homo sapiens 17.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265517 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265517&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020055 377004391 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505075 NC(=O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(O)nc3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H19ClN6O5/c24-15-3-1-14(2-4-15)12-29-21(28-22(33)30(23(29)34)13-19(25)31)27-16-5-7-17(8-6-16)35-18-9-10-20(32)26-11-18/h1-11H,12-13H2,(H2,25,31)(H,26,32)(H,27,28,33) UIOFTOMXRUQKKE-UHFFFAOYSA-N 265518 US9718790, I-1900 P2X purinoceptor 3 Homo sapiens 16.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265518 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265518&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019745 377004392 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505076 CC(C)Cn1ccc2cc(ccc12)\N=c1/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C27H30ClN5O4/c1-17(2)14-31-12-11-19-13-21(9-10-22(19)31)29-24-30-25(36)33(16-27(3,4)23(34)35)26(37)32(24)15-18-5-7-20(28)8-6-18/h5-13,17H,14-16H2,1-4H3,(H,34,35)(H,29,30,36) LSTHKOYNWJFZGC-UHFFFAOYSA-N 183338 US9150546, I-508::US9688643, I-508::US9718790, I-0517 P2X purinoceptor 3 Homo sapiens 511 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183338 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183338&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578383 313634738 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505077 CCOc1ccc(cc1Br)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(C)cc1 265520 US9718790, I-1179 P2X purinoceptor 3 Homo sapiens 33.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265520 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265520&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278496 377004394 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505078 CNC(=O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(O)nc3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H21ClN6O5/c1-26-21(33)14-31-23(34)29-22(30(24(31)35)13-15-2-4-16(25)5-3-15)28-17-6-8-18(9-7-17)36-19-10-11-20(32)27-12-19/h2-12H,13-14H2,1H3,(H,26,33)(H,27,32)(H,28,29,34) ZFZDLHVGFJZPBA-UHFFFAOYSA-N 265521 US9718790, I-1901 P2X purinoceptor 3 Homo sapiens 15.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265521 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265521&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020507 377004395 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505079 CCCn1ccc2cc(ccc12)\N=c1/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C26H28ClN5O4/c1-4-12-30-13-11-18-14-20(9-10-21(18)30)28-23-29-24(35)32(16-26(2,3)22(33)34)25(36)31(23)15-17-5-7-19(27)8-6-17/h5-11,13-14H,4,12,15-16H2,1-3H3,(H,33,34)(H,28,29,35) OWGZMAZZYUSLCJ-UHFFFAOYSA-N 183339 US9150546, I-509::US9688643, I-509::US9718790, I-0518 P2X purinoceptor 3 Homo sapiens 652 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183339 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183339&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578485 313634739 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505081 OCCNC(=O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(O)nc3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H23ClN6O6/c26-17-3-1-16(2-4-17)14-31-23(30-24(36)32(25(31)37)15-22(35)27-11-12-33)29-18-5-7-19(8-6-18)38-20-9-10-21(34)28-13-20/h1-10,13,33H,11-12,14-15H2,(H,27,35)(H,28,34)(H,29,30,36) ZKGUCUQURIVEFR-UHFFFAOYSA-N 265523 US9718790, I-1902 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265523 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265523&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945260 377004397 C04080 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505082 CSc1cccc(c1)\N=c1/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C22H23ClN4O4S/c1-22(2,18(28)29)13-27-20(30)25-19(24-16-5-4-6-17(11-16)32-3)26(21(27)31)12-14-7-9-15(23)10-8-14/h4-11H,12-13H2,1-3H3,(H,28,29)(H,24,25,30) DQUCQFHPLJOMDY-UHFFFAOYSA-N 183340 US9150546, I-510::US9688643, I-510::US9718790, I-0519 P2X purinoceptor 3 Homo sapiens 98.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183340 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183340&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578919 313634740 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505084 COC(=O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccnc(O)c3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H20ClN5O6/c1-35-21(32)14-30-23(33)28-22(29(24(30)34)13-15-2-4-16(25)5-3-15)27-17-6-8-18(9-7-17)36-19-10-11-26-20(31)12-19/h2-12H,13-14H2,1H3,(H,26,31)(H,27,28,33) LEAMUVRAKNGQFD-UHFFFAOYSA-N 265525 US9718790, I-1903 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265525 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265525&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020565 377004399 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505085 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(F)c2)n(Cc2ccc(C)cc2)c1=O 183341 US9150546, I-515::US9688643, I-515::US9718790, I-0524 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183341 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183341&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578641 313634741 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505086 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(OC3CCCCC3)nc2)n(Cc2ccc(C)cc2)c1=O 265527 US9718790, I-1184 P2X purinoceptor 3 Homo sapiens 138 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265527 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265527&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019602 377004401 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505087 COC(=O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(C)nc3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H22ClN5O5/c1-16-3-10-21(13-27-16)36-20-11-8-19(9-12-20)28-23-29-24(33)31(15-22(32)35-2)25(34)30(23)14-17-4-6-18(26)7-5-17/h3-13H,14-15H2,1-2H3,(H,28,29,33) QYVIKFIEVOKDSY-UHFFFAOYSA-N 265528 US9718790, I-1904 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265528 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265528&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020508 377004402 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505088 CCOC(=O)CCCn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(Cl)c2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C26H31ClN4O5/c1-5-35-23(32)7-6-14-30-25(33)29-24(28-20-12-13-22(21(27)15-20)36-17(2)3)31(26(30)34)16-19-10-8-18(4)9-11-19/h8-13,15,17H,5-7,14,16H2,1-4H3,(H,28,29,33) SGZWRROGODEEEX-UHFFFAOYSA-N 183342 US9150546, I-516::US9688643, I-516::US9718790, I-0525 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183342 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183342&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578724 313634742 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505089 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(OC3CCCC3)nc2)n(Cc2ccc(C)cc2)c1=O 265530 US9718790, I-1185 P2X purinoceptor 3 Homo sapiens 116 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265530 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265530&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019660 377004404 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505090 CC(C)Oc1ccc(cc1C)\N=c1/[nH]c(=O)n(CC(CO)CO)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C24H29ClN4O5/c1-15(2)34-21-9-8-20(10-16(21)3)26-22-27-23(32)29(12-18(13-30)14-31)24(33)28(22)11-17-4-6-19(25)7-5-17/h4-10,15,18,30-31H,11-14H2,1-3H3,(H,26,27,32) WWFZLKJKCWJRSR-UHFFFAOYSA-N 265531 US9718790, I-1905 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265531 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265531&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020537 377004405 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505091 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(C)cc1 183343 US9150546, I-517::US9688643, I-517::US9718790, I-0526 P2X purinoceptor 3 Homo sapiens 15.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183343 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183343&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578710 313634743 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505092 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(OC3CCCC3)cc2)n(Cc2ccc(C)cc2)c1=O 265533 US9718790, I-1186 P2X purinoceptor 3 Homo sapiens 33.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265533&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278229 377004407 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506263 CC(=O)Nc1cc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(C)c(=O)n2Cc2ccc(Cl)cc2)ccn1 InChI=1S/C24H21ClN6O4/c1-15(32)27-21-13-20(11-12-26-21)35-19-9-7-18(8-10-19)28-22-29-23(33)30(2)24(34)31(22)14-16-3-5-17(25)6-4-16/h3-13H,14H2,1-2H3,(H,26,27,32)(H,28,29,33) LBSWBWCYRRQRGG-UHFFFAOYSA-N 266697 US9718790, I-2431 P2X purinoceptor 3 Homo sapiens 18.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266697 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266697&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020050 377005568 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506264 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccnc(c3)C(=O)NC)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H22ClFN6O4/c1-3-32-24(35)31-23(33(25(32)36)14-15-4-6-16(26)7-5-15)30-17-8-9-21(19(27)12-17)37-18-10-11-29-20(13-18)22(34)28-2/h4-13H,3,14H2,1-2H3,(H,28,34)(H,30,31,35) DLHJALRVLVWQSF-UHFFFAOYSA-N 266698 US9718790, I-2432 P2X purinoceptor 3 Homo sapiens 2.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266698 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266698&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020070 377005569 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506265 CNC(=O)c1cc(Oc2ccc(cc2F)\N=c2/[nH]c(=O)n(C)c(=O)n2Cc2ccc(Cl)cc2)ccn1 InChI=1S/C24H20ClFN6O4/c1-27-21(33)19-12-17(9-10-28-19)36-20-8-7-16(11-18(20)26)29-22-30-23(34)31(2)24(35)32(22)13-14-3-5-15(25)6-4-14/h3-12H,13H2,1-2H3,(H,27,33)(H,29,30,34) MWEOKORNMQYMAR-UHFFFAOYSA-N 266699 US9718790, I-2433 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266699 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266699&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019881 377005570 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506266 CCOC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccon3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H22ClN5O6/c1-2-34-21(31)11-13-29-23(32)27-22(30(24(29)33)15-16-3-5-17(25)6-4-16)26-18-7-9-19(10-8-18)36-20-12-14-35-28-20/h3-10,12,14H,2,11,13,15H2,1H3,(H,26,27,32) DANKXJNFOJWBBE-UHFFFAOYSA-N 266700 US9718790, I-2434 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266700 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266700&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020116 377005571 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506267 OC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccon3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C22H18ClN5O6/c23-15-3-1-14(2-4-15)13-28-20(25-21(31)27(22(28)32)11-9-19(29)30)24-16-5-7-17(8-6-16)34-18-10-12-33-26-18/h1-8,10,12H,9,11,13H2,(H,29,30)(H,24,25,31) CNHVWLBIYDNFFT-UHFFFAOYSA-N 266701 US9718790, I-2435 P2X purinoceptor 3 Homo sapiens 37.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266701 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266701&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020046 377005572 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506268 OC[C@@H](O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(F)n3)cc2)n(Cc2ccc(Cl)cc2)c1=O 266702 US9718790, I-2436 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266702 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266702&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278662 377005573 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506269 OCC(CO)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3nccs3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H22ClN5O5S/c24-17-3-1-15(2-4-17)11-28-20(27-21(32)29(23(28)33)12-16(13-30)14-31)26-18-5-7-19(8-6-18)34-22-25-9-10-35-22/h1-10,16,30-31H,11-14H2,(H,26,27,32) AMRHNMVGQGWRDB-UHFFFAOYSA-N 266703 US9718790, I-2437 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266703 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266703&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945711 377005574 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506270 OCCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccon3)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C21H17ClFN5O5/c22-14-3-1-13(2-4-14)12-28-19(25-20(30)27(8-9-29)21(28)31)24-15-5-6-17(16(23)11-15)33-18-7-10-32-26-18/h1-7,10-11,29H,8-9,12H2,(H,24,25,30) AKLBBTFJYVOACJ-UHFFFAOYSA-N 266704 US9718790, I-2438 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266704 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266704&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945687 377005575 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506271 OCC(CO)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccon3)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H21ClFN5O6/c24-16-3-1-14(2-4-16)10-29-21(27-22(33)30(23(29)34)11-15(12-31)13-32)26-17-5-6-19(18(25)9-17)36-20-7-8-35-28-20/h1-9,15,31-32H,10-13H2,(H,26,27,33) LGHPIPZLWIGARV-UHFFFAOYSA-N 266705 US9718790, I-2439 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266705 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266705&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945674 377005576 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506272 OC[C@@H](O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccon3)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O 266706 US9718790, I-2440 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266706 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266706&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019879 377005577 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506273 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(Cl)n3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H19Cl2N5O3/c1-2-29-22(31)28-21(30(23(29)32)14-15-6-8-16(24)9-7-15)26-17-10-12-18(13-11-17)33-20-5-3-4-19(25)27-20/h3-13H,2,14H2,1H3,(H,26,28,31) HYYJYHWWLJIXJG-UHFFFAOYSA-N 266707 US9718790, I-2441 P2X purinoceptor 3 Homo sapiens 10.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266707 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266707&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 88558778 377005578 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506274 Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(cn3)C(O)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H18ClN5O5/c1-28-22(32)27-21(29(23(28)33)13-14-2-5-16(24)6-3-14)26-17-7-9-18(10-8-17)34-19-11-4-15(12-25-19)20(30)31/h2-12H,13H2,1H3,(H,30,31)(H,26,27,32) LMKXXIZPVAFAGI-UHFFFAOYSA-N 266708 US9718790, I-2442 P2X purinoceptor 3 Homo sapiens 18.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266708 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266708&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020056 377005579 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506275 NC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccon3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C22H19ClN6O5/c23-15-3-1-14(2-4-15)13-29-20(26-21(31)28(22(29)32)11-9-18(24)30)25-16-5-7-17(8-6-16)34-19-10-12-33-27-19/h1-8,10,12H,9,11,13H2,(H2,24,30)(H,25,26,31) RCGOWEJTLCRUEV-UHFFFAOYSA-N 266709 US9718790, I-2443 P2X purinoceptor 3 Homo sapiens 24.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266709 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266709&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020097 377005580 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506276 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cc(ncn3)C(O)=O)cc2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C24H22N6O5/c1-3-29-23(33)28-22(30(24(29)34)13-16-6-4-15(2)5-7-16)27-17-8-10-18(11-9-17)35-20-12-19(21(31)32)25-14-26-20/h4-12,14H,3,13H2,1-2H3,(H,31,32)(H,27,28,33) ZUULIPCNSYXSNF-UHFFFAOYSA-N 266710 US9718790, I-2444 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266710 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266710&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019638 377005581 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506277 Cc1ccc(Cn2c(=O)n(C)c(=O)[nH]\c2=N/c2ccc(Oc3cc(ncn3)C(O)=O)cc2)cc1 InChI=1S/C23H20N6O5/c1-14-3-5-15(6-4-14)12-29-21(27-22(32)28(2)23(29)33)26-16-7-9-17(10-8-16)34-19-11-18(20(30)31)24-13-25-19/h3-11,13H,12H2,1-2H3,(H,30,31)(H,26,27,32) YTAUWSIXOQEYBB-UHFFFAOYSA-N 266711 US9718790, I-2445 P2X purinoceptor 3 Homo sapiens 13.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266711 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266711&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019737 377005582 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506278 C[C@H]1CC[C@H](Cn2c(=O)n(C)c(=O)[nH]\c2=N/c2ccc(Oc3cccc(n3)C#N)cc2)CC1 266712 US9718790, I-2446 P2X purinoceptor 3 Homo sapiens 1.000 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266712 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266712&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945528 377005583 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506279 Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cc(ncn3)C(O)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C22H17ClN6O5/c1-28-21(32)27-20(29(22(28)33)11-13-2-4-14(23)5-3-13)26-15-6-8-16(9-7-15)34-18-10-17(19(30)31)24-12-25-18/h2-10,12H,11H2,1H3,(H,30,31)(H,26,27,32) JXVOBICWMVKXRJ-UHFFFAOYSA-N 266713 US9718790, I-2447 P2X purinoceptor 3 Homo sapiens 10.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266713 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266713&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019867 377005584 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506280 OCC(O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3nccs3)cc2)n(Cc2ccc(Cl)cc2)c1=O 266714 US9718790, I-2448 P2X purinoceptor 3 Homo sapiens 11.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266714 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266714&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019708 377005585 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506281 OCCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc4[nH]cnc4c3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H21ClN6O4/c26-17-3-1-16(2-4-17)14-32-23(30-24(34)31(11-12-33)25(32)35)29-18-5-7-19(8-6-18)36-20-9-10-21-22(13-20)28-15-27-21/h1-10,13,15,33H,11-12,14H2,(H,27,28)(H,29,30,34) VXQIYBFBSQLZHN-UHFFFAOYSA-N 266715 US9718790, I-2449 P2X purinoceptor 3 Homo sapiens 9.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266715 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266715&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019779 377005586 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506282 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3nc(C(O)=O)c(C)s3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H20ClN5O5S/c1-3-28-21(32)27-20(29(23(28)33)12-14-4-6-15(24)7-5-14)25-16-8-10-17(11-9-16)34-22-26-18(19(30)31)13(2)35-22/h4-11H,3,12H2,1-2H3,(H,30,31)(H,25,27,32) YRRMGQAZBUJQJV-UHFFFAOYSA-N 266716 US9718790, I-2450 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266716 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266716&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945676 377005587 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506283 Cc1sc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(C)c(=O)n2Cc2ccc(Cl)cc2)nc1C(O)=O InChI=1S/C22H18ClN5O5S/c1-12-17(18(29)30)25-21(34-12)33-16-9-7-15(8-10-16)24-19-26-20(31)27(2)22(32)28(19)11-13-3-5-14(23)6-4-13/h3-10H,11H2,1-2H3,(H,29,30)(H,24,26,31) SGVFYTXNSZNCEZ-UHFFFAOYSA-N 266717 US9718790, I-2451 P2X purinoceptor 3 Homo sapiens 25.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266717 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266717&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019709 377005588 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506284 OCCCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccn[nH]3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C22H21ClN6O4/c23-16-4-2-15(3-5-16)14-29-20(26-21(31)28(22(29)32)12-1-13-30)25-17-6-8-18(9-7-17)33-19-10-11-24-27-19/h2-11,30H,1,12-14H2,(H,24,27)(H,25,26,31) VOPTWMPGHMPJFS-UHFFFAOYSA-N 266718 US9718790, I-2452 P2X purinoceptor 3 Homo sapiens 36.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266718 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266718&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945578 377005589 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506285 OC[C@@H](O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccn[nH]3)cc2)n(Cc2ccc(Cl)cc2)c1=O 266719 US9718790, I-2453 P2X purinoceptor 3 Homo sapiens 64.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266719 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266719&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278242 377005590 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506286 OCC(CO)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccn[nH]3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H23ClN6O5/c24-17-3-1-15(2-4-17)11-29-21(27-22(33)30(23(29)34)12-16(13-31)14-32)26-18-5-7-19(8-6-18)35-20-9-10-25-28-20/h1-10,16,31-32H,11-14H2,(H,25,28)(H,26,27,33) JSNZFTNZLPYQKQ-UHFFFAOYSA-N 266720 US9718790, I-2454 P2X purinoceptor 3 Homo sapiens 35.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266720 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266720&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945739 377005591 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506287 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccn[nH]3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C21H19ClN6O3/c1-2-27-20(29)25-19(28(21(27)30)13-14-3-5-15(22)6-4-14)24-16-7-9-17(10-8-16)31-18-11-12-23-26-18/h3-12H,2,13H2,1H3,(H,23,26)(H,24,25,29) ZZKJPPSZNNYTJO-UHFFFAOYSA-N 266721 US9718790, I-2455 P2X purinoceptor 3 Homo sapiens 63.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266721 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266721&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278629 377005592 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506288 Cc1cnc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(CC(O)CO)c(=O)n2Cc2ccc(Cl)cc2)s1 266722 US9718790, I-2456 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266722 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266722&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021179 377005593 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506289 Cc1cnc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(CCO)c(=O)n2Cc2ccc(Cl)cc2)s1 InChI=1S/C22H20ClN5O4S/c1-14-12-24-21(33-14)32-18-8-6-17(7-9-18)25-19-26-20(30)27(10-11-29)22(31)28(19)13-15-2-4-16(23)5-3-15/h2-9,12,29H,10-11,13H2,1H3,(H,25,26,30) YADXXQNQWPWQDO-UHFFFAOYSA-N 266723 US9718790, I-2457 P2X purinoceptor 3 Homo sapiens 13.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266723 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266723&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021207 377005594 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506290 Cc1cnc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(CC(CO)CO)c(=O)n2Cc2ccc(Cl)cc2)s1 InChI=1S/C24H24ClN5O5S/c1-15-10-26-23(36-15)35-20-8-6-19(7-9-20)27-21-28-22(33)30(12-17(13-31)14-32)24(34)29(21)11-16-2-4-18(25)5-3-16/h2-10,17,31-32H,11-14H2,1H3,(H,27,28,33) CDMCTGSJUMALOG-UHFFFAOYSA-N 266724 US9718790, I-2458 P2X purinoceptor 3 Homo sapiens 3.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266724 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266724&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021183 377005595 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506291 COC(=O)[C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3ccon3)cc2)n(Cc2ccc(Cl)cc2)c1=O 266725 US9718790, I-2459 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266725 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266725&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021177 377005596 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506292 COC(=O)[C@@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3ccon3)cc2)n(Cc2ccc(Cl)cc2)c1=O 266726 US9718790, I-2460 P2X purinoceptor 3 Homo sapiens 35.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266726 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266726&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945656 377005597 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506293 Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccnc(c3)C(O)=O)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H17ClFN5O5/c1-29-22(33)28-21(30(23(29)34)12-13-2-4-14(24)5-3-13)27-15-6-7-19(17(25)10-15)35-16-8-9-26-18(11-16)20(31)32/h2-11H,12H2,1H3,(H,31,32)(H,27,28,33) GNHFEDKJJBBFFI-UHFFFAOYSA-N 266727 US9718790, I-2461 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266727 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266727&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019868 377005598 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506294 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccnc(c3)C(O)=O)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H19ClFN5O5/c1-2-30-23(34)29-22(31(24(30)35)13-14-3-5-15(25)6-4-14)28-16-7-8-20(18(26)11-16)36-17-9-10-27-19(12-17)21(32)33/h3-12H,2,13H2,1H3,(H,32,33)(H,28,29,34) IEUFDBKLBLTXAS-UHFFFAOYSA-N 266728 US9718790, I-2462 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266728 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266728&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278243 377005599 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506295 C[C@H]1CC[C@H](Cn2c(=O)n(C)c(=O)[nH]\c2=N/c2ccc(Oc3cccc(n3)C(N)=O)cc2)CC1 266729 US9718790, I-2463 P2X purinoceptor 3 Homo sapiens 3.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266729 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266729&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945522 377005600 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506296 Cc1ccc(Cn2c(=O)n(C)c(=O)[nH]\c2=N/c2ccc(Oc3ccc(cn3)C(N)=O)cc2)cc1 InChI=1S/C24H22N6O4/c1-15-3-5-16(6-4-15)14-30-22(28-23(32)29(2)24(30)33)27-18-8-10-19(11-9-18)34-20-12-7-17(13-26-20)21(25)31/h3-13H,14H2,1-2H3,(H2,25,31)(H,27,28,32) NCMYXTSNTANRHC-UHFFFAOYSA-N 266730 US9718790, I-2464 P2X purinoceptor 3 Homo sapiens 10.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266730 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266730&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020645 377005601 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506297 C[C@H]1CC[C@H](Cn2c(=O)n(C)c(=O)[nH]\c2=N/c2ccc(Oc3cccc(n3)C(O)=O)cc2)CC1 266731 US9718790, I-2465 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266731 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266731&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020647 377005602 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506298 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(n3)C#N)cc2)n(Cc2ccc(F)cc2)c1=O InChI=1S/C24H19FN6O3/c1-2-30-23(32)29-22(31(24(30)33)15-16-6-8-17(25)9-7-16)28-18-10-12-20(13-11-18)34-21-5-3-4-19(14-26)27-21/h3-13H,2,15H2,1H3,(H,28,29,32) SFTVYJSXNMWKPM-UHFFFAOYSA-N 266732 US9718790, I-2466 P2X purinoceptor 3 Homo sapiens 16.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266732 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266732&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278409 377005603 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506299 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cncc(n3)C(=O)OC)cc2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C25H24N6O5/c1-4-30-24(33)29-23(31(25(30)34)15-17-7-5-16(2)6-8-17)27-18-9-11-19(12-10-18)36-21-14-26-13-20(28-21)22(32)35-3/h5-14H,4,15H2,1-3H3,(H,27,29,33) HHECYQPQBVVUJS-UHFFFAOYSA-N 266733 US9718790, I-2467 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266733 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266733&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020596 377005604 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506300 COC(=O)c1cncc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(C)c(=O)n2Cc2ccc(C)cc2)n1 InChI=1S/C24H22N6O5/c1-15-4-6-16(7-5-15)14-30-22(28-23(32)29(2)24(30)33)26-17-8-10-18(11-9-17)35-20-13-25-12-19(27-20)21(31)34-3/h4-13H,14H2,1-3H3,(H,26,28,32) VCCAKEBDHUJUJO-UHFFFAOYSA-N 266734 US9718790, I-2468 P2X purinoceptor 3 Homo sapiens 20.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266734 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266734&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021100 377005605 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506301 COC(=O)c1cncc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(C)c(=O)n2Cc2ccc(Cl)cc2)n1 InChI=1S/C23H19ClN6O5/c1-29-22(32)28-21(30(23(29)33)13-14-3-5-15(24)6-4-14)26-16-7-9-17(10-8-16)35-19-12-25-11-18(27-19)20(31)34-2/h3-12H,13H2,1-2H3,(H,26,28,32) OVQGHTFDYJSKFX-UHFFFAOYSA-N 266735 US9718790, I-2469 P2X purinoceptor 3 Homo sapiens 19.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266735 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266735&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021075 377005606 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506302 Clc1ccc(Cn2c(=O)n(CCOC3CCCCO3)c(=O)[nH]\c2=N/c2ccc(Oc3ccsn3)cc2)cc1 266736 US9718790, I-2470 P2X purinoceptor 3 Homo sapiens <1 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266736 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266736&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021078 377005607 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506303 Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cncc(n3)C(N)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C22H18ClN7O4/c1-29-21(32)28-20(30(22(29)33)12-13-2-4-14(23)5-3-13)26-15-6-8-16(9-7-15)34-18-11-25-10-17(27-18)19(24)31/h2-11H,12H2,1H3,(H2,24,31)(H,26,28,32) HPOZGYXWDIMBGN-UHFFFAOYSA-N 266737 US9718790, I-2471 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266737 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266737&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021108 377005608 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506304 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cncc(n3)C(N)=O)cc2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C24H23N7O4/c1-3-30-23(33)29-22(31(24(30)34)14-16-6-4-15(2)5-7-16)27-17-8-10-18(11-9-17)35-20-13-26-12-19(28-20)21(25)32/h4-13H,3,14H2,1-2H3,(H2,25,32)(H,27,29,33) MXBYMTUIACVCFN-UHFFFAOYSA-N 266738 US9718790, I-2472 P2X purinoceptor 3 Homo sapiens 3.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266738 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266738&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278440 377005609 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506305 Cc1ccc(Cn2c(=O)n(C)c(=O)[nH]\c2=N/c2ccc(Oc3cncc(n3)C(N)=O)cc2)cc1 InChI=1S/C23H21N7O4/c1-14-3-5-15(6-4-14)13-30-21(28-22(32)29(2)23(30)33)26-16-7-9-17(10-8-16)34-19-12-25-11-18(27-19)20(24)31/h3-12H,13H2,1-2H3,(H2,24,31)(H,26,28,32) ZNDVPWVAQFQUJH-UHFFFAOYSA-N 266739 US9718790, I-2473 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266739 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266739&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945463 377005610 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506306 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cncc(n3)C(O)=O)cc2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C24H22N6O5/c1-3-29-23(33)28-22(30(24(29)34)14-16-6-4-15(2)5-7-16)26-17-8-10-18(11-9-17)35-20-13-25-12-19(27-20)21(31)32/h4-13H,3,14H2,1-2H3,(H,31,32)(H,26,28,33) LXGWLGXKRXXTCO-UHFFFAOYSA-N 266740 US9718790, I-2474 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266740 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266740&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945682 377005611 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506307 Cc1ccc(Cn2c(=O)n(C)c(=O)[nH]\c2=N/c2ccc(Oc3cncc(n3)C(O)=O)cc2)cc1 InChI=1S/C23H20N6O5/c1-14-3-5-15(6-4-14)13-29-21(27-22(32)28(2)23(29)33)25-16-7-9-17(10-8-16)34-19-12-24-11-18(26-19)20(30)31/h3-12H,13H2,1-2H3,(H,30,31)(H,25,27,32) DXVPJIFJSNYDPU-UHFFFAOYSA-N 266741 US9718790, I-2475 P2X purinoceptor 3 Homo sapiens 12.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266741 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266741&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278244 377005612 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506308 Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cncc(n3)C(O)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C22H17ClN6O5/c1-28-21(32)27-20(29(22(28)33)12-13-2-4-14(23)5-3-13)25-15-6-8-16(9-7-15)34-18-11-24-10-17(26-18)19(30)31/h2-11H,12H2,1H3,(H,30,31)(H,25,27,32) IGNPNBFLXLVZMU-UHFFFAOYSA-N 266742 US9718790, I-2476 P2X purinoceptor 3 Homo sapiens 13.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266742 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266742&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021210 377005613 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506309 OCCn1c(=O)[nH]\c(=N/c2ccc(Oc3cnsn3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C20H17ClN6O4S/c21-14-3-1-13(2-4-14)12-27-18(24-19(29)26(9-10-28)20(27)30)23-15-5-7-16(8-6-15)31-17-11-22-32-25-17/h1-8,11,28H,9-10,12H2,(H,23,24,29) JXRIEHQCNREORS-UHFFFAOYSA-N 266743 US9718790, I-2477 P2X purinoceptor 3 Homo sapiens 15.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266743 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266743&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021206 377005614 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506310 OCC(CO)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cnsn3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C22H21ClN6O5S/c23-16-3-1-14(2-4-16)10-28-20(26-21(32)29(22(28)33)11-15(12-30)13-31)25-17-5-7-18(8-6-17)34-19-9-24-35-27-19/h1-9,15,30-31H,10-13H2,(H,25,26,32) QQMYIDQAJTUBRV-UHFFFAOYSA-N 266744 US9718790, I-2478 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266744 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266744&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021205 377005615 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506311 OC[C@@H](O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cnsn3)cc2)n(Cc2ccc(Cl)cc2)c1=O 266745 US9718790, I-2479 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266745 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266745&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278636 377005616 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506312 CC[C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3ccnc(c3)C(O)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O 266746 US9718790, I-2480 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266746 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266746&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945695 377005617 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506313 CC[C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3cncc(c3)C(O)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O 266747 US9718790, I-2481 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266747 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266747&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278369 377005618 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506314 CC[C@@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3ccnc(c3)C(O)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O 266748 US9718790, I-2482 P2X purinoceptor 3 Homo sapiens 11.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266748 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266748&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945466 377005619 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506315 CC[C@@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3cncc(c3)C(O)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O 266749 US9718790, I-2483 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266749 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266749&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278663 377005620 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506316 OC(=O)c1cc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(C3CCC3)c(=O)n2Cc2ccc(Cl)cc2)ccn1 InChI=1S/C26H22ClN5O5/c27-17-6-4-16(5-7-17)15-31-24(30-25(35)32(26(31)36)19-2-1-3-19)29-18-8-10-20(11-9-18)37-21-12-13-28-22(14-21)23(33)34/h4-14,19H,1-3,15H2,(H,33,34)(H,29,30,35) CPPZAHBFLHVMHL-UHFFFAOYSA-N 266750 US9718790, I-2484 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266750 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266750&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278410 377005621 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506317 OC(=O)c1cncc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(C3CCC3)c(=O)n2Cc2ccc(Cl)cc2)c1 InChI=1S/C26H22ClN5O5/c27-18-6-4-16(5-7-18)15-31-24(30-25(35)32(26(31)36)20-2-1-3-20)29-19-8-10-21(11-9-19)37-22-12-17(23(33)34)13-28-14-22/h4-14,20H,1-3,15H2,(H,33,34)(H,29,30,35) ADLQVUXKWVNNPO-UHFFFAOYSA-N 266751 US9718790, I-2485 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266751 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266751&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278664 377005622 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506318 C[C@H](C(O)=O)n1c(=O)[nH]\c(=N/c2ccc(Oc3ccon3)cc2)n(Cc2ccc(Cl)cc2)c1=O 266752 US9718790, I-2486 P2X purinoceptor 3 Homo sapiens 381 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266752 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266752&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278245 377005623 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506319 C[C@H](CO)n1c(=O)[nH]\c(=N/c2ccc(Oc3ccon3)cc2)n(Cc2ccc(Cl)cc2)c1=O 266753 US9718790, I-2488 P2X purinoceptor 3 Homo sapiens 37.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266753 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266753&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020618 377005624 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506320 C[C@@H](CO)n1c(=O)[nH]\c(=N/c2ccc(Oc3ccon3)cc2)n(Cc2ccc(Cl)cc2)c1=O 266754 US9718790, I-2489 P2X purinoceptor 3 Homo sapiens 50.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266754 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266754&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020620 377005625 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506321 OCCOCCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccon3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H22ClN5O6/c24-17-3-1-16(2-4-17)15-29-21(26-22(31)28(23(29)32)10-13-33-14-11-30)25-18-5-7-19(8-6-18)35-20-9-12-34-27-20/h1-9,12,30H,10-11,13-15H2,(H,25,26,31) HNRDVCSOYPDCQQ-UHFFFAOYSA-N 266755 US9718790, I-2490 P2X purinoceptor 3 Homo sapiens 10.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266755 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266755&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020560 377005626 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506322 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cc(C(O)=O)n(C)n3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H21ClN6O5/c1-3-29-22(33)26-21(30(23(29)34)13-14-4-6-15(24)7-5-14)25-16-8-10-17(11-9-16)35-19-12-18(20(31)32)28(2)27-19/h4-12H,3,13H2,1-2H3,(H,31,32)(H,25,26,33) UJUUSHGGXWBORQ-UHFFFAOYSA-N 266756 US9718790, I-2491 P2X purinoceptor 3 Homo sapiens 74.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266756 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266756&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020568 377005627 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506323 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(n3)C#N)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H18ClFN6O3/c1-2-31-23(33)30-22(32(24(31)34)14-15-6-8-16(25)9-7-15)29-17-10-11-20(19(26)12-17)35-21-5-3-4-18(13-27)28-21/h3-12H,2,14H2,1H3,(H,29,30,33) OOKNLMKQLJSRNQ-UHFFFAOYSA-N 266757 US9718790, I-2492 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266757 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266757&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278441 377005628 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506324 Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(n3)C#N)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H16ClFN6O3/c1-30-22(32)29-21(31(23(30)33)13-14-5-7-15(24)8-6-14)28-16-9-10-19(18(25)11-16)34-20-4-2-3-17(12-26)27-20/h2-11H,13H2,1H3,(H,28,29,32) WSVDQEVGNZUMGW-UHFFFAOYSA-N 266758 US9718790, I-2493 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266758 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266758&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278246 377005629 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506325 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(n3)C#N)cc2)n(C[C@H]2CC[C@H](C)CC2)c1=O 266759 US9718790, I-2494 P2X purinoceptor 3 Homo sapiens 1.000 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266759 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266759&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945718 377005630 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506326 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(n3)C(N)=O)cc2)n(Cc2ccc(F)cc2)c1=O InChI=1S/C24H21FN6O4/c1-2-30-23(33)29-22(31(24(30)34)14-15-6-8-16(25)9-7-15)27-17-10-12-18(13-11-17)35-20-5-3-4-19(28-20)21(26)32/h3-13H,2,14H2,1H3,(H2,26,32)(H,27,29,33) GKRFFHNSOCSDPS-UHFFFAOYSA-N 266760 US9718790, I-2495 P2X purinoceptor 3 Homo sapiens 21.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266760 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266760&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278442 377005631 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506327 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(n3)C(O)=O)cc2)n(Cc2ccc(F)cc2)c1=O InChI=1S/C24H20FN5O5/c1-2-29-23(33)28-22(30(24(29)34)14-15-6-8-16(25)9-7-15)26-17-10-12-18(13-11-17)35-20-5-3-4-19(27-20)21(31)32/h3-13H,2,14H2,1H3,(H,31,32)(H,26,28,33) ZAUVHZCIEZSYCB-UHFFFAOYSA-N 266761 US9718790, I-2496 P2X purinoceptor 3 Homo sapiens 30.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266761 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266761&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278370 377005632 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506328 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(n3)C(N)=O)cc2)n(C[C@H]2CC[C@H](C)CC2)c1=O 266762 US9718790, I-2497 P2X purinoceptor 3 Homo sapiens 1.000 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266762 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266762&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278637 377005633 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504600 CCOC(=O)C1(Cn2c(=O)[nH]\c(=N/c3ccc(OCC(C)C)cc3)n(Cc3ccc(Cl)cc3)c2=O)CC1 InChI=1S/C27H31ClN4O5/c1-4-36-23(33)27(13-14-27)17-32-25(34)30-24(29-21-9-11-22(12-10-21)37-16-18(2)3)31(26(32)35)15-19-5-7-20(28)8-6-19/h5-12,18H,4,13-17H2,1-3H3,(H,29,30,34) FQNRLANANWNKFS-UHFFFAOYSA-N 265048 US9718790, I-1007 P2X purinoceptor 3 Homo sapiens 15.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265048 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265048&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945046 377003924 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504601 CC(C)Oc1ccc(cc1C)\N=c1/[nH]c(=O)n(CC2CN(CC(O)=O)C2)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C26H30ClN5O5/c1-16(2)37-22-9-8-21(10-17(22)3)28-24-29-25(35)32(14-19-11-30(12-19)15-23(33)34)26(36)31(24)13-18-4-6-20(27)7-5-18/h4-10,16,19H,11-15H2,1-3H3,(H,33,34)(H,28,29,35) QNJSAYCYEAPYBC-UHFFFAOYSA-N 265049 US9718790, I-1678 P2X purinoceptor 3 Homo sapiens 111 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265049 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265049&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020161 377003925 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504602 COc1ccc(Cn2c(=O)nc(Nc3ccc(OC(C)C)c(F)c3)n(Cc3ccc(Cl)cc3)c2=O)cc1 InChI=1S/C27H26ClFN4O4/c1-17(2)37-24-13-10-21(14-23(24)29)30-25-31-26(34)33(16-19-6-11-22(36-3)12-7-19)27(35)32(25)15-18-4-8-20(28)9-5-18/h4-14,17H,15-16H2,1-3H3,(H,30,31,34) JVNJNDPHOPMJGS-UHFFFAOYSA-N 183180 US9150546, I-343::US9688643, I-343::US9718790, I-0343 P2X purinoceptor 3 Homo sapiens 21.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183180 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183180&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821071 313634580 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504603 CC(C)COc1ccc(cc1)\N=c1/[nH]c(=O)n(CC2(CC2)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C25H27ClN4O5/c1-16(2)14-35-20-9-7-19(8-10-20)27-22-28-23(33)30(15-25(11-12-25)21(31)32)24(34)29(22)13-17-3-5-18(26)6-4-17/h3-10,16H,11-15H2,1-2H3,(H,31,32)(H,27,28,33) ONDMEWLXLKSZGA-UHFFFAOYSA-N 265051 US9718790, I-1008 P2X purinoceptor 3 Homo sapiens 108 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265051 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265051&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278170 377003927 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504604 Cc1nc2ccc(cc2s1)\N=c1/[nH]c(=O)n(CCO)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C20H18ClN5O3S/c1-12-22-16-7-6-15(10-17(16)30-12)23-18-24-19(28)25(8-9-27)20(29)26(18)11-13-2-4-14(21)5-3-13/h2-7,10,27H,8-9,11H2,1H3,(H,23,24,28) JREINWJKEHXJLH-UHFFFAOYSA-N 265052 US9718790, I-1679 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265052 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265052&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278359 377003928 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504605 CCCCc1ccc(Nc2nc(=O)n(CCO)c(=O)n2Cc2ccc(Cl)cc2)cc1 InChI=1S/C22H25ClN4O3/c1-2-3-4-16-7-11-19(12-8-16)24-20-25-21(29)26(13-14-28)22(30)27(20)15-17-5-9-18(23)10-6-17/h5-12,28H,2-4,13-15H2,1H3,(H,24,25,29) NFHXSNPUKNDNLC-UHFFFAOYSA-N 183181 US9150546, I-344::US9688643, I-344::US9718790, I-0344 P2X purinoceptor 3 Homo sapiens 128 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183181 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183181&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821446 313634581 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504606 CC(C)Oc1ccc(cc1C)\N=c1/[nH]c(=O)n(CC(=O)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C23H23ClN4O6/c1-13(2)34-19-9-8-17(10-14(19)3)25-21-26-22(32)28(12-18(29)20(30)31)23(33)27(21)11-15-4-6-16(24)7-5-15/h4-10,13H,11-12H2,1-3H3,(H,30,31)(H,25,26,32) OTWPWDTURZYAOL-UHFFFAOYSA-N 265054 US9718790, I-1009 P2X purinoceptor 3 Homo sapiens 69.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265054 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265054&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019487 377003930 C00972 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504607 OC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(OCc3ccncc3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H22ClN5O5/c26-19-3-1-17(2-4-19)15-31-23(29-24(34)30(25(31)35)14-11-22(32)33)28-20-5-7-21(8-6-20)36-16-18-9-12-27-13-10-18/h1-10,12-13H,11,14-16H2,(H,32,33)(H,28,29,34) MFKPQNUOYYZBJB-UHFFFAOYSA-N 265055 US9718790, I-1680 P2X purinoceptor 3 Homo sapiens 730 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265055 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265055&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020309 377003931 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504608 CC(C)Oc1ccc(Nc2nc(=O)n(CC=C)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C22H22ClFN4O3/c1-4-11-27-21(29)26-20(25-17-9-10-19(18(24)12-17)31-14(2)3)28(22(27)30)13-15-5-7-16(23)8-6-15/h4-10,12,14H,1,11,13H2,2-3H3,(H,25,26,29) KVIXRQVJVQCDSK-UHFFFAOYSA-N 183182 US9150546, I-346::US9688643, I-346::US9718790, I-0346 P2X purinoceptor 3 Homo sapiens 16.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183182 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183182&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821368 313634582 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504609 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(CC2(CO)COC2)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C24H26Cl2N4O5/c1-15(2)35-20-8-7-18(9-19(20)26)27-21-28-22(32)30(11-24(12-31)13-34-14-24)23(33)29(21)10-16-3-5-17(25)6-4-16/h3-9,15,31H,10-14H2,1-2H3,(H,27,28,32) GVSZIMCXZGFZQR-UHFFFAOYSA-N 265057 US9718790, I-1010 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265057 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265057&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 86689122 377003933 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504610 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc3nc(N)sc3c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 265058 US9718790, I-1682 P2X purinoceptor 3 Homo sapiens 140 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265058 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265058&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278199 377003934 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504611 CC(C)Oc1ccc(Nc2nc(=O)n(CCO)c(=O)n2Cc2ccc(cc2)[N+]([O-])=O)cc1F InChI=1S/C21H22FN5O6/c1-13(2)33-18-8-5-15(11-17(18)22)23-19-24-20(29)25(9-10-28)21(30)26(19)12-14-3-6-16(7-4-14)27(31)32/h3-8,11,13,28H,9-10,12H2,1-2H3,(H,23,24,29) VPITVNBBSGONIS-UHFFFAOYSA-N 183183 US9150546, I-347::US9688643, I-347::US9718790, I-0347 P2X purinoceptor 3 Homo sapiens 251 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183183 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183183&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821178 313634583 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504612 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(CC2(COC2)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C24H24Cl2N4O6/c1-14(2)36-19-8-7-17(9-18(19)26)27-21-28-22(33)30(11-24(20(31)32)12-35-13-24)23(34)29(21)10-15-3-5-16(25)6-4-15/h3-9,14H,10-13H2,1-2H3,(H,31,32)(H,27,28,33) DRBJDLBGGRPKLH-UHFFFAOYSA-N 265060 US9718790, I-1011 P2X purinoceptor 3 Homo sapiens 21.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265060 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265060&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 86689121 377003936 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504613 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc3oc(cc3c2)-c2ccccc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 265061 US9718790, I-1683 P2X purinoceptor 3 Homo sapiens 310 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265061 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265061&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945201 377003937 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504614 CCCn1c(=O)nc(Nc2ccc(OC(C)C)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C22H24ClFN4O3/c1-4-11-27-21(29)26-20(25-17-9-10-19(18(24)12-17)31-14(2)3)28(22(27)30)13-15-5-7-16(23)8-6-15/h5-10,12,14H,4,11,13H2,1-3H3,(H,25,26,29) JPYJUMSFDCRFTJ-UHFFFAOYSA-N 183184 US9150546, I-348::US9688643, I-348::US9718790, I-0348 P2X purinoceptor 3 Homo sapiens 13.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183184 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183184&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821127 313634584 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504615 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(CC(CO)(CO)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C24H26Cl2N4O7/c1-14(2)37-19-8-7-17(9-18(19)26)27-21-28-22(35)30(11-24(12-31,13-32)20(33)34)23(36)29(21)10-15-3-5-16(25)6-4-15/h3-9,14,31-32H,10-13H2,1-2H3,(H,33,34)(H,27,28,35) OEBUMJJCQORPLV-UHFFFAOYSA-N 265063 US9718790, I-1012 P2X purinoceptor 3 Homo sapiens 51.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265063 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265063&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278171 377003939 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504616 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc3nc(ccc3c2)C(F)(F)F)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 265064 US9718790, I-1686 P2X purinoceptor 3 Homo sapiens 115 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265064 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265064&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278200 377003940 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504617 CCCn1c(=O)nc(Nc2ccc(OC(C)C)c(F)c2)n(Cc2ccccc2)c1=O InChI=1S/C22H25FN4O3/c1-4-12-26-21(28)25-20(27(22(26)29)14-16-8-6-5-7-9-16)24-17-10-11-19(18(23)13-17)30-15(2)3/h5-11,13,15H,4,12,14H2,1-3H3,(H,24,25,28) QOJKTYIYEBVLFQ-UHFFFAOYSA-N 183185 US9150546, I-349::US9688643, I-349::US9718790, I-0349 P2X purinoceptor 3 Homo sapiens 113 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183185 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183185&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821075 313634585 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504618 CC[C@@H](C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(C)cc1 265066 US9718790, I-1013 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265066 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265066&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020078 377003942 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504619 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc3cnccc3c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 265067 US9718790, I-1689 P2X purinoceptor 3 Homo sapiens 882 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265067 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265067&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020163 377003943 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504620 CC(C)Oc1ccc(Nc2nc(=O)n(CCOC3CCCCO3)c(=O)n2Cc2ccc(Cl)cc2)cc1Cl InChI=1S/C26H30Cl2N4O5/c1-17(2)37-22-11-10-20(15-21(22)28)29-24-30-25(33)31(12-14-36-23-5-3-4-13-35-23)26(34)32(24)16-18-6-8-19(27)9-7-18/h6-11,15,17,23H,3-5,12-14,16H2,1-2H3,(H,29,30,33) HYEDLAYHBGAJBN-UHFFFAOYSA-N 183186 US9150546, I-350::US9688643, I-350::US9718790, I-0350 P2X purinoceptor 3 Homo sapiens 10.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183186 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183186&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821217 313634586 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504621 CC[C@H](C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(C)cc1 265069 US9718790, I-1014 P2X purinoceptor 3 Homo sapiens 17.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265069 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265069&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278483 377003945 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504622 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc3nc(S)sc3c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 265070 US9718790, I-1691 P2X purinoceptor 3 Homo sapiens 22.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265070 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265070&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945610 377003946 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504623 CC(C)Oc1ccc(Nc2nc(=O)n(CCO)c(=O)n2Cc2ccc(Cl)cc2)cc1Cl InChI=1S/C21H22Cl2N4O4/c1-13(2)31-18-8-7-16(11-17(18)23)24-19-25-20(29)26(9-10-28)21(30)27(19)12-14-3-5-15(22)6-4-14/h3-8,11,13,28H,9-10,12H2,1-2H3,(H,24,25,29) LVLPRWHJRHKWQM-UHFFFAOYSA-N 183187 US9150546, I-351::US9688643, I-351::US9718790, I-0351 P2X purinoceptor 3 Homo sapiens 15.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183187 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183187&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821305 313634587 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504624 CC[C@@H](C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(C[C@H](C)C(=O)OC)c(=O)n1Cc1ccc(C)cc1 265072 US9718790, I-1015 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265072 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265072&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945166 377003948 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504625 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc3n(CCO)cnc3c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 265073 US9718790, I-1692 P2X purinoceptor 3 Homo sapiens 582 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265073 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265073&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945527 377003949 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504626 CC(C)Oc1ccc(Nc2nc(=O)n(CCC(=O)NCCO)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C24H27ClFN5O5/c1-15(2)36-20-8-7-18(13-19(20)26)28-22-29-23(34)30(11-9-21(33)27-10-12-32)24(35)31(22)14-16-3-5-17(25)6-4-16/h3-8,13,15,32H,9-12,14H2,1-2H3,(H,27,33)(H,28,29,34) CWCRNKZFRUTYCW-UHFFFAOYSA-N 183188 US9150546, I-352::US9688643, I-352::US9718790, I-0352 P2X purinoceptor 3 Homo sapiens 36.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183188 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183188&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821100 313634588 C04080 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504627 CC[C@H](C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(C[C@H](C)C(=O)OC)c(=O)n1Cc1ccc(C)cc1 265075 US9718790, I-1016 P2X purinoceptor 3 Homo sapiens 17.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265075 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265075&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945326 377003951 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504628 CCc1oc2ccc(cc2c1C)\N=c1/[nH]c(=O)n(CCCC(=O)OC)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C26H27ClN4O5/c1-4-21-16(2)20-14-19(11-12-22(20)36-21)28-24-29-25(33)30(13-5-6-23(32)35-3)26(34)31(24)15-17-7-9-18(27)10-8-17/h7-12,14H,4-6,13,15H2,1-3H3,(H,28,29,33) PUQSKFBAPCJSKM-UHFFFAOYSA-N 265076 US9718790, I-1700 P2X purinoceptor 3 Homo sapiens 12.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265076 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265076&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020954 377003952 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504629 CC(C)Oc1ccc(Nc2nc(=O)n(CC(=O)NCCO)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C23H25ClFN5O5/c1-14(2)35-19-8-7-17(11-18(19)25)27-21-28-22(33)30(13-20(32)26-9-10-31)23(34)29(21)12-15-3-5-16(24)6-4-15/h3-8,11,14,31H,9-10,12-13H2,1-2H3,(H,26,32)(H,27,28,33) ORMVFHWWSZHFJA-UHFFFAOYSA-N 183189 US9150546, I-353::US9688643, I-353::US9718790, I-0353 P2X purinoceptor 3 Homo sapiens 18.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183189 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183189&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 77888221 313634589 C04080 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504630 CC(C)Oc1ccc(cc1C)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(cc1)C(C)C 265078 US9718790, I-1017 P2X purinoceptor 3 Homo sapiens 550 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265078 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265078&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019533 377003954 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504631 CCc1nc2ccc(cc2s1)\N=c1/[nH]c(=O)n(CCCC(=O)OC)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C24H24ClN5O4S/c1-3-20-27-18-11-10-17(13-19(18)35-20)26-22-28-23(32)29(12-4-5-21(31)34-2)24(33)30(22)14-15-6-8-16(25)9-7-15/h6-11,13H,3-5,12,14H2,1-2H3,(H,26,28,32) IGGCOBZOXZXPMW-UHFFFAOYSA-N 265079 US9718790, I-1701 P2X purinoceptor 3 Homo sapiens 3.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265079 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265079&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019628 377003955 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504632 CCOC(=O)CCn1c(=O)nc(Nc2ccc(OC(C)C)c(Cl)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H26Cl2N4O5/c1-4-34-21(31)11-12-29-23(32)28-22(27-18-9-10-20(19(26)13-18)35-15(2)3)30(24(29)33)14-16-5-7-17(25)8-6-16/h5-10,13,15H,4,11-12,14H2,1-3H3,(H,27,28,32) VHGWQSUSWLECNQ-UHFFFAOYSA-N 183190 US9150546, I-354::US9688643, I-354::US9718790, I-0354 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183190 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183190&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821037 313634590 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504633 CCOC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(O[C@H](C)CC)cc2)n(Cc2ccc(C)cc2)c1=O 265081 US9718790, I-1018 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265081 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265081&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278296 377003957 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504634 CCn1c(=O)[nH]\c(=N/c2ccc3nc(C)sc3c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C20H18ClN5O2S/c1-3-25-19(27)24-18(23-15-8-9-16-17(10-15)29-12(2)22-16)26(20(25)28)11-13-4-6-14(21)7-5-13/h4-10H,3,11H2,1-2H3,(H,23,24,27) JFPGTNYZTJAXGA-UHFFFAOYSA-N 265082 US9718790, I-1702 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265082 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265082&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019768 377003958 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504635 CC(C)Oc1ccc(Nc2nc(=O)n(CCC(O)=O)c(=O)n2Cc2ccc(Cl)cc2)cc1Cl InChI=1S/C22H22Cl2N4O5/c1-13(2)33-18-8-7-16(11-17(18)24)25-20-26-21(31)27(10-9-19(29)30)22(32)28(20)12-14-3-5-15(23)6-4-14/h3-8,11,13H,9-10,12H2,1-2H3,(H,29,30)(H,25,26,31) LTHMPYWKRCESAL-UHFFFAOYSA-N 183191 US9150546, I-355::US9688643, I-355::US9718790, I-0355 P2X purinoceptor 3 Homo sapiens 20.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183191 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183191&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821101 313634591 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504636 CCOC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(O[C@H](C)CC)c(C)c2)n(Cc2ccc(C)cc2)c1=O 265084 US9718790, I-1019 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265084 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265084&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278172 377003960 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504637 CCc1nc2ccc(cc2s1)\N=c1/[nH]c(=O)n(CC)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C21H20ClN5O2S/c1-3-18-24-16-10-9-15(11-17(16)30-18)23-19-25-20(28)26(4-2)21(29)27(19)12-13-5-7-14(22)8-6-13/h5-11H,3-4,12H2,1-2H3,(H,23,25,28) BXQMPMXRNMDGFI-UHFFFAOYSA-N 265085 US9718790, I-1703 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265085 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265085&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019682 377003961 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504638 CCOC(=O)CCn1c(=O)nc(Nc2ccc(OC(C)C)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H26ClFN4O5/c1-4-34-21(31)11-12-29-23(32)28-22(27-18-9-10-20(19(26)13-18)35-15(2)3)30(24(29)33)14-16-5-7-17(25)8-6-16/h5-10,13,15H,4,11-12,14H2,1-3H3,(H,27,28,32) LDMWUXAYSNMZOT-UHFFFAOYSA-N 183192 US9150546, I-356::US9688643, I-356::US9718790, I-0356 P2X purinoceptor 3 Homo sapiens 12.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183192 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183192&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821391 313634592 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504639 CCOC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(O[C@H](C)CC)c(Cl)c2)n(Cc2ccc(C)cc2)c1=O 265087 US9718790, I-1020 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265087 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265087&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945322 377003963 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504640 CCc1oc2ccc(cc2c1C)\N=c1/[nH]c(=O)n(CCCC(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C25H25ClN4O5/c1-3-20-15(2)19-13-18(10-11-21(19)35-20)27-23-28-24(33)29(12-4-5-22(31)32)25(34)30(23)14-16-6-8-17(26)9-7-16/h6-11,13H,3-5,12,14H2,1-2H3,(H,31,32)(H,27,28,33) SIDSIPYWSAMXKO-UHFFFAOYSA-N 265088 US9718790, I-1704 P2X purinoceptor 3 Homo sapiens 15.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265088 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265088&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019581 377003964 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504641 OCCCn1c(=O)nc(Nc2cccc(c2)C(F)(F)F)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C20H18ClF3N4O3/c21-15-7-5-13(6-8-15)12-28-17(26-18(30)27(19(28)31)9-2-10-29)25-16-4-1-3-14(11-16)20(22,23)24/h1,3-8,11,29H,2,9-10,12H2,(H,25,26,30) DOVAEUUVRWPLHI-UHFFFAOYSA-N 183193 US9150546, I-357::US9688643, I-357::US9718790, I-0357 P2X purinoceptor 3 Homo sapiens 47.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183193 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183193&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821023 313634593 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504642 CCOC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(O[C@H](C)C(F)(F)F)cc2)n(Cc2ccc(C)cc2)c1=O 265090 US9718790, I-1021 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265090 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265090&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019571 377003966 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504643 CCc1nc2ccc(cc2s1)\N=c1/[nH]c(=O)n(CCCC(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C23H22ClN5O4S/c1-2-19-26-17-10-9-16(12-18(17)34-19)25-21-27-22(32)28(11-3-4-20(30)31)23(33)29(21)13-14-5-7-15(24)8-6-14/h5-10,12H,2-4,11,13H2,1H3,(H,30,31)(H,25,27,32) RTEKKIVZNCVJAT-UHFFFAOYSA-N 265091 US9718790, I-1705 P2X purinoceptor 3 Homo sapiens 14.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265091 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265091&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019684 377003967 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504644 CC(C)Cc1ccc(Nc2nc(=O)n(CCCO)c(=O)n2Cc2ccc(Cl)cc2)cc1 InChI=1S/C23H27ClN4O3/c1-16(2)14-17-6-10-20(11-7-17)25-21-26-22(30)27(12-3-13-29)23(31)28(21)15-18-4-8-19(24)9-5-18/h4-11,16,29H,3,12-15H2,1-2H3,(H,25,26,30) KQESQAJPTWDTMT-UHFFFAOYSA-N 183194 US9150546, I-358::US9688643, I-358::US9718790, I-0358 P2X purinoceptor 3 Homo sapiens 55.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183194 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183194&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821234 313634594 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504645 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(OC(F)F)c(Cl)c2)n(Cc2ccc(C)cc2)c1=O 265093 US9718790, I-1022 P2X purinoceptor 3 Homo sapiens 14.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265093 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265093&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019613 377003969 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504646 CC[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc3oc(CC)c(C)c3c2)n(Cc2ccc(Cl)cc2)c1=O)NC(C)=O 265094 US9718790, I-1708 P2X purinoceptor 3 Homo sapiens 17.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265094 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265094&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021113 377003970 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504647 CC(C)Oc1ccc(Nc2nc(=O)n(CCCO)c(=O)n2Cc2ccc(Cl)cc2)cc1 InChI=1S/C22H25ClN4O4/c1-15(2)31-19-10-8-18(9-11-19)24-20-25-21(29)26(12-3-13-28)22(30)27(20)14-16-4-6-17(23)7-5-16/h4-11,15,28H,3,12-14H2,1-2H3,(H,24,25,29) XMOQRFWNARHCLH-UHFFFAOYSA-N 183195 US9150546, I-359::US9688643, I-359::US9718790, I-0359 P2X purinoceptor 3 Homo sapiens 40.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183195 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183195&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821252 313634595 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504648 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(CCC3CC3)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O 265096 US9718790, I-1023 P2X purinoceptor 3 Homo sapiens 300 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265096 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265096&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945086 377003972 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504649 CC(C)Oc1ccc(cc1C)\N=c1/[nH]c(=O)n(C2CNC2)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C23H26ClN5O3/c1-14(2)32-20-9-8-18(10-15(20)3)26-21-27-22(30)29(19-11-25-12-19)23(31)28(21)13-16-4-6-17(24)7-5-16/h4-10,14,19,25H,11-13H2,1-3H3,(H,26,27,30) NGTAZIKHYCJKHJ-UHFFFAOYSA-N 265097 US9718790, I-1709 P2X purinoceptor 3 Homo sapiens 167 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265097 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265097&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021117 377003973 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504650 OCCCn1c(=O)nc(Nc2ccc(OC(F)F)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C20H19ClF2N4O4/c21-14-4-2-13(3-5-14)12-27-18(25-19(29)26(20(27)30)10-1-11-28)24-15-6-8-16(9-7-15)31-17(22)23/h2-9,17,28H,1,10-12H2,(H,24,25,29) YRRWZMDHZPCEJW-UHFFFAOYSA-N 183196 US9150546, I-360::US9688643, I-360::US9718790, I-0360 P2X purinoceptor 3 Homo sapiens 148 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183196 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183196&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821343 313634596 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504651 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(CCC3CC3)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 265099 US9718790, I-1024 P2X purinoceptor 3 Homo sapiens 161 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265099 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265099&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019614 377003975 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504652 CCc1oc2ccc(cc2c1C)\N=c1/[nH]c(=O)n(CCCC(N)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C25H26ClN5O4/c1-3-20-15(2)19-13-18(10-11-21(19)35-20)28-23-29-24(33)30(12-4-5-22(27)32)25(34)31(23)14-16-6-8-17(26)9-7-16/h6-11,13H,3-5,12,14H2,1-2H3,(H2,27,32)(H,28,29,33) DYHGCCSQLNNMDB-UHFFFAOYSA-N 265100 US9718790, I-1710 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265100 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265100&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021084 377003976 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504653 CCOc1ccc(Nc2nc(=O)n(CCCO)c(=O)n2Cc2ccc(Cl)cc2)cc1 InChI=1S/C21H23ClN4O4/c1-2-30-18-10-8-17(9-11-18)23-19-24-20(28)25(12-3-13-27)21(29)26(19)14-15-4-6-16(22)7-5-15/h4-11,27H,2-3,12-14H2,1H3,(H,23,24,28) MQGOIKGFIRWKLK-UHFFFAOYSA-N 183197 US9150546, I-361::US9688643, I-361::US9718790, I-0361 P2X purinoceptor 3 Homo sapiens 76.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183197 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183197&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821375 313634597 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504654 COC(=O)[C@@H](C)[C@H](C)n1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O 265102 US9718790, I-1025 P2X purinoceptor 3 Homo sapiens 134 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265102 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265102&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019555 377003978 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504655 CCc1nc2ccc(cc2s1)\N=c1/[nH]c(=O)n(CCCC(N)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C23H23ClN6O3S/c1-2-20-27-17-10-9-16(12-18(17)34-20)26-21-28-22(32)29(11-3-4-19(25)31)23(33)30(21)13-14-5-7-15(24)8-6-14/h5-10,12H,2-4,11,13H2,1H3,(H2,25,31)(H,26,28,32) SKEGCJSONVTRRM-UHFFFAOYSA-N 265103 US9718790, I-1711 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265103 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265103&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019631 377003979 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504656 CC(C)Oc1ccc(Nc2nc(=O)n(CCCO)c(=O)n2Cc2ccc(Cl)cc2)cc1Cl InChI=1S/C22H24Cl2N4O4/c1-14(2)32-19-9-8-17(12-18(19)24)25-20-26-21(30)27(10-3-11-29)22(31)28(20)13-15-4-6-16(23)7-5-15/h4-9,12,14,29H,3,10-11,13H2,1-2H3,(H,25,26,30) CGVREEYRNJNDLQ-UHFFFAOYSA-N 183198 US9150546, I-362::US9688643, I-362::US9718790, I-0362 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183198 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183198&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821189 313634598 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504657 CC(C)Oc1ccc(cc1C)\N=c1/[nH]c(=O)n([C@@H](C)[C@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 265105 US9718790, I-1026 P2X purinoceptor 3 Homo sapiens 182 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265105 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265105&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019831 377003981 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504658 OCCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccnc(O)c3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H20ClN5O5/c24-16-3-1-15(2-4-16)14-29-21(27-22(32)28(11-12-30)23(29)33)26-17-5-7-18(8-6-17)34-19-9-10-25-20(31)13-19/h1-10,13,30H,11-12,14H2,(H,25,31)(H,26,27,32) LNJBUUJDIZTXQY-UHFFFAOYSA-N 265106 US9718790, I-1712 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265106 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265106&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019589 377003982 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504659 CC(C)Oc1ccc(Nc2nc(=O)n(CCCC(O)=O)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C23H24ClFN4O5/c1-14(2)34-19-10-9-17(12-18(19)25)26-21-27-22(32)28(11-3-4-20(30)31)23(33)29(21)13-15-5-7-16(24)8-6-15/h5-10,12,14H,3-4,11,13H2,1-2H3,(H,30,31)(H,26,27,32) PRGQUPCLZCUZSW-UHFFFAOYSA-N 183199 US9150546, I-363::US9688643, I-363::US9718790, I-0363 P2X purinoceptor 3 Homo sapiens 78.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183199 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183199&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821307 313634599 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504660 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(OC(F)(F)F)c(Cl)c2)n(Cc2ccc(C)cc2)c1=O 265108 US9718790, I-1027 P2X purinoceptor 3 Homo sapiens 41.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265108 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265108&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019909 377003984 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504661 OCCCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccnc(O)c3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H22ClN5O5/c25-17-4-2-16(3-5-17)15-30-22(28-23(33)29(24(30)34)12-1-13-31)27-18-6-8-19(9-7-18)35-20-10-11-26-21(32)14-20/h2-11,14,31H,1,12-13,15H2,(H,26,32)(H,27,28,33) GCFZXKPFALKEOL-UHFFFAOYSA-N 265109 US9718790, I-1713 P2X purinoceptor 3 Homo sapiens 3.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265109 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265109&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278361 377003985 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504662 CC(C)Oc1ccc(Nc2nc(=O)n(CC(C)(C)C(O)=O)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C24H26ClFN4O5/c1-14(2)35-19-10-9-17(11-18(19)26)27-21-28-22(33)30(13-24(3,4)20(31)32)23(34)29(21)12-15-5-7-16(25)8-6-15/h5-11,14H,12-13H2,1-4H3,(H,31,32)(H,27,28,33) CAYYASMSWISXDA-UHFFFAOYSA-N 183200 US9150546, I-364::US9688643, I-364::US9718790, I-0364 P2X purinoceptor 3 Homo sapiens 30.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183200 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183200&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821363 313634600 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504663 CC[C@@H](C)Oc1ccc(cc1)\N=c1/[nH]c(=O)n(CCC(O)=O)c(=O)n1Cc1ccc(C)cc1 265111 US9718790, I-1028 P2X purinoceptor 3 Homo sapiens 78.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265111 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265111&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945167 377003987 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504664 OCC(CO)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccnc(O)c3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H24ClN5O6/c26-18-3-1-16(2-4-18)12-30-23(29-24(35)31(25(30)36)13-17(14-32)15-33)28-19-5-7-20(8-6-19)37-21-9-10-27-22(34)11-21/h1-11,17,32-33H,12-15H2,(H,27,34)(H,28,29,35) RRGDTIRMJRRZHT-UHFFFAOYSA-N 265112 US9718790, I-1714 P2X purinoceptor 3 Homo sapiens 3.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265112 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265112&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019590 377003988 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504665 CC(C)Oc1ccc(Nc2nc(=O)n(CCCCO)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C23H26ClFN4O4/c1-15(2)33-20-10-9-18(13-19(20)25)26-21-27-22(31)28(11-3-4-12-30)23(32)29(21)14-16-5-7-17(24)8-6-16/h5-10,13,15,30H,3-4,11-12,14H2,1-2H3,(H,26,27,31) WIVQLHRBUYZELM-UHFFFAOYSA-N 183201 US9150546, I-365::US9688643, I-365::US9718790, I-0365 P2X purinoceptor 3 Homo sapiens 18.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183201 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183201&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821405 313634601 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505093 CCOc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(CC(CO)CO)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C22H24Cl2N4O5/c1-2-33-19-8-7-17(9-18(19)24)25-20-26-21(31)28(11-15(12-29)13-30)22(32)27(20)10-14-3-5-16(23)6-4-14/h3-9,15,29-30H,2,10-13H2,1H3,(H,25,26,31) GAXJVLMGBWEWFZ-UHFFFAOYSA-N 265534 US9718790, I-1906 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265534 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265534&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278618 377004408 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505094 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(C)cc1 183344 US9150546, I-518::US9688643, I-518::US9718790, I-0527 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183344 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183344&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578621 313634744 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505095 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(OC3CCC3)nc2)n(Cc2ccc(C)cc2)c1=O 265536 US9718790, I-1187 P2X purinoceptor 3 Homo sapiens 58.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265536 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265536&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020117 377004410 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505096 CCOc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(C[C@H](O)CO)c(=O)n1Cc1ccc(Cl)cc1 265537 US9718790, I-1907 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265537 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265537&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021126 377004411 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505097 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(CCCC(O)=O)c(=O)n1Cc1ccc(C)cc1 InChI=1S/C24H27ClN4O5/c1-15(2)34-20-11-10-18(13-19(20)25)26-22-27-23(32)28(12-4-5-21(30)31)24(33)29(22)14-17-8-6-16(3)7-9-17/h6-11,13,15H,4-5,12,14H2,1-3H3,(H,30,31)(H,26,27,32) NXLSNMXBBXKVGK-UHFFFAOYSA-N 183345 US9150546, I-519::US9688643, I-519::US9718790, I-0528 P2X purinoceptor 3 Homo sapiens 12.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183345 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183345&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578649 313634745 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505098 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(OC3CCCCC3)nc2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 265539 US9718790, I-1188 P2X purinoceptor 3 Homo sapiens 131 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265539 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265539&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278561 377004413 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505099 C[C@@H](Oc1ccc(cc1)\N=c1/[nH]c(=O)n(CCC(O)=O)c(=O)n1Cc1ccc(Cl)cc1)C(F)(F)F 265540 US9718790, I-1908 P2X purinoceptor 3 Homo sapiens 70.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265540 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265540&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021095 377004414 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505100 Cc1cc2cc(ccc2o1)\N=c1/[nH]c(=O)n(CCCC(O)=O)c(=O)n1Cc1ccc(C)cc1 InChI=1S/C24H24N4O5/c1-15-5-7-17(8-6-15)14-28-22(25-19-9-10-20-18(13-19)12-16(2)33-20)26-23(31)27(24(28)32)11-3-4-21(29)30/h5-10,12-13H,3-4,11,14H2,1-2H3,(H,29,30)(H,25,26,31) MQVCATJXUIBEEK-UHFFFAOYSA-N 183346 US9150546, I-520::US9688643, I-520::US9718790, I-0529 P2X purinoceptor 3 Homo sapiens 80.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183346 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183346&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578423 313634746 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505101 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(OC3CCCC3)cc2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 265542 US9718790, I-1189 P2X purinoceptor 3 Homo sapiens 33.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265542 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265542&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020118 377004416 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505102 CCOC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(F)c2)n(CC2CCCCCCC2)c1=O InChI=1S/C26H37FN4O5/c1-4-35-23(32)14-15-30-25(33)29-24(28-20-12-13-22(21(27)16-20)36-18(2)3)31(26(30)34)17-19-10-8-6-5-7-9-11-19/h12-13,16,18-19H,4-11,14-15,17H2,1-3H3,(H,28,29,33) RNMTYGKEOMSCKS-UHFFFAOYSA-N 265543 US9718790, I-1911 P2X purinoceptor 3 Homo sapiens 253 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265543 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265543&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945275 377004417 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505103 CCOC(=O)CCCn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(C)c2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C27H34N4O5/c1-6-35-24(32)8-7-15-30-26(33)29-25(28-22-13-14-23(20(5)16-22)36-18(2)3)31(27(30)34)17-21-11-9-19(4)10-12-21/h9-14,16,18H,6-8,15,17H2,1-5H3,(H,28,29,33) CBVQUWBWGAGXAO-UHFFFAOYSA-N 183347 US9150546, I-521::US9688643, I-521::US9718790, I-0530 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183347 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183347&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578914 313634747 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505104 CCOC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(C=C)c2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C27H32N4O5/c1-6-21-16-22(12-13-23(21)36-18(3)4)28-25-29-26(33)30(15-14-24(32)35-7-2)27(34)31(25)17-20-10-8-19(5)9-11-20/h6,8-13,16,18H,1,7,14-15,17H2,2-5H3,(H,28,29,33) FWIWSFNFTZKNDJ-UHFFFAOYSA-N 265545 US9718790, I-1190 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265545 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265545&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020189 377004418 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505105 CNC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(OCC3CC3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H26ClN5O4/c1-26-21(31)12-13-29-23(32)28-22(30(24(29)33)14-16-4-6-18(25)7-5-16)27-19-8-10-20(11-9-19)34-15-17-2-3-17/h4-11,17H,2-3,12-15H2,1H3,(H,26,31)(H,27,28,32) QCRLXUCSNNQPHP-UHFFFAOYSA-N 265546 US9718790, I-1912 P2X purinoceptor 3 Homo sapiens 29.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265546 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265546&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945651 377004419 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505106 COC(=O)C[C@H](C)n1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(Cl)c2)n(Cc2ccc(Cl)cc2)c1=O 183348 US9150546, I-522::US9688643, I-522::US9718790, I-0531 P2X purinoceptor 3 Homo sapiens 29.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183348 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183348&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578461 313634748 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505107 CCOc1ccc(cc1C=C)\N=c1/[nH]c(=O)n(C[C@H](C)C(=O)OC)c(=O)n1Cc1ccc(C)cc1 265548 US9718790, I-1191 P2X purinoceptor 3 Homo sapiens 22.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265548 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265548&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020858 377004421 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505108 CNC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(OC3CCC3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H26ClN5O4/c1-26-21(31)13-14-29-23(32)28-22(30(24(29)33)15-16-5-7-17(25)8-6-16)27-18-9-11-20(12-10-18)34-19-3-2-4-19/h5-12,19H,2-4,13-15H2,1H3,(H,26,31)(H,27,28,32) JPYMBAQXSSTJJO-UHFFFAOYSA-N 265549 US9718790, I-1913 P2X purinoceptor 3 Homo sapiens 19.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265549 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265549&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945569 377004422 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505109 COC(=O)C[C@H](C)n1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O 183349 US9150546, I-523::US9688643, I-523::US9718790, I-0532 P2X purinoceptor 3 Homo sapiens 72.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183349 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183349&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578435 313634749 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505110 CC(C)Oc1ccc(cc1C=C)\N=c1/[nH]c(=O)n(CCC(O)=O)c(=O)n1Cc1ccc(C)cc1 InChI=1S/C25H28N4O5/c1-5-19-14-20(10-11-21(19)34-16(2)3)26-23-27-24(32)28(13-12-22(30)31)25(33)29(23)15-18-8-6-17(4)7-9-18/h5-11,14,16H,1,12-13,15H2,2-4H3,(H,30,31)(H,26,27,32) PQZMOSDXOJLMRU-UHFFFAOYSA-N 265551 US9718790, I-1192 P2X purinoceptor 3 Homo sapiens 20.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265551 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265551&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020847 377004424 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505111 NC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(OCC3CC3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H24ClN5O4/c24-17-5-3-15(4-6-17)13-29-21(27-22(31)28(23(29)32)12-11-20(25)30)26-18-7-9-19(10-8-18)33-14-16-1-2-16/h3-10,16H,1-2,11-14H2,(H2,25,30)(H,26,27,31) XCFXIBHNVAZQGF-UHFFFAOYSA-N 265552 US9718790, I-1914 P2X purinoceptor 3 Homo sapiens 46.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265552 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265552&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117756879 377004425 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505112 COC(=O)C[C@H](C)n1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O 183350 US9150546, I-524::US9688643, I-524::US9718790, I-0533 P2X purinoceptor 3 Homo sapiens 60.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183350 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183350&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578592 313634750 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505113 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(\C=C\C3CC3)cc2)n(Cc2ccc(C)cc2)c1=O 265554 US9718790, I-1193 P2X purinoceptor 3 Homo sapiens 40.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265554 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265554&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020861 377004427 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505114 NC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(OC3CCC3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H24ClN5O4/c24-16-6-4-15(5-7-16)14-29-21(27-22(31)28(23(29)32)13-12-20(25)30)26-17-8-10-19(11-9-17)33-18-2-1-3-18/h4-11,18H,1-3,12-14H2,(H2,25,30)(H,26,27,31) MQYHRGMAFCTIAH-UHFFFAOYSA-N 265555 US9718790, I-1915 P2X purinoceptor 3 Homo sapiens 23.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265555 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265555&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278576 377004428 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505115 CC(C)Oc1ccc(cc1C)\N=c1/[nH]c(=O)n(CCCC(O)=O)c(=O)n1Cc1ccc(C)cc1 InChI=1S/C25H30N4O5/c1-16(2)34-21-12-11-20(14-18(21)4)26-23-27-24(32)28(13-5-6-22(30)31)25(33)29(23)15-19-9-7-17(3)8-10-19/h7-12,14,16H,5-6,13,15H2,1-4H3,(H,30,31)(H,26,27,32) PTNDSIGCKJDYDW-UHFFFAOYSA-N 183351 US9150546, I-525::US9688643, I-525::US9718790, I-0534 P2X purinoceptor 3 Homo sapiens 54.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183351 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183351&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578449 313634751 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505116 CCOc1ccc(cc1C=C)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(C)cc1 265557 US9718790, I-1194 P2X purinoceptor 3 Homo sapiens 31.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265557 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265557&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020839 377004430 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505117 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n(CCC(O)=O)c(=O)n1CC1CCCCCCC1 InChI=1S/C24H33FN4O5/c1-16(2)34-20-11-10-18(14-19(20)25)26-22-27-23(32)28(13-12-21(30)31)24(33)29(22)15-17-8-6-4-3-5-7-9-17/h10-11,14,16-17H,3-9,12-13,15H2,1-2H3,(H,30,31)(H,26,27,32) IQAWTERUVVRROA-UHFFFAOYSA-N 265558 US9718790, I-1916 P2X purinoceptor 3 Homo sapiens 995 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265558 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265558&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019749 377004431 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505118 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n([C@@H](C)CC(O)=O)c(=O)n1Cc1ccc(Cl)cc1 183352 US9150546, I-526::US9688643, I-526::US9718790, I-0535 P2X purinoceptor 3 Homo sapiens 24.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183352 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183352&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578743 313634752 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505119 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Br)c(OC)c2)n(Cc2ccc(C)cc2)c1=O 265560 US9718790, I-1195 P2X purinoceptor 3 Homo sapiens 221 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265560 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265560&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945197 377004433 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505120 OCCCn1c(=O)[nH]\c(=N/c2ccc(OCC3CC3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H25ClN4O4/c24-18-6-4-16(5-7-18)14-28-21(26-22(30)27(23(28)31)12-1-13-29)25-19-8-10-20(11-9-19)32-15-17-2-3-17/h4-11,17,29H,1-3,12-15H2,(H,25,26,30) KXIDPCDXCNBGDD-UHFFFAOYSA-N 265561 US9718790, I-1917 P2X purinoceptor 3 Homo sapiens 23.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265561 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265561&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019725 377004434 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505121 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n([C@@H](C)CC(O)=O)c(=O)n1Cc1ccc(Cl)cc1 183353 US9150546, I-527::US9688643, I-527::US9718790, I-0536 P2X purinoceptor 3 Homo sapiens 33.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183353 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183353&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578893 313634753 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505122 COC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(CC(C)C)c(OC)c2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C26H32N4O5/c1-17(2)14-20-10-11-21(15-22(20)34-4)27-24-28-25(32)29(13-12-23(31)35-5)26(33)30(24)16-19-8-6-18(3)7-9-19/h6-11,15,17H,12-14,16H2,1-5H3,(H,27,28,32) IEVUNZJYZRUGLZ-UHFFFAOYSA-N 265563 US9718790, I-1197 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265563 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265563&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278562 377004436 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505123 OCCCn1c(=O)[nH]\c(=N/c2ccc(OC3CCC3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H25ClN4O4/c24-17-7-5-16(6-8-17)15-28-21(26-22(30)27(23(28)31)13-2-14-29)25-18-9-11-20(12-10-18)32-19-3-1-4-19/h5-12,19,29H,1-4,13-15H2,(H,25,26,30) GRXNQLGYMRDPTP-UHFFFAOYSA-N 265564 US9718790, I-1918 P2X purinoceptor 3 Homo sapiens 12.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265564 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265564&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019726 377004437 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505124 CC(C)Oc1ccc(cc1C)\N=c1/[nH]c(=O)n([C@@H](C)CC(O)=O)c(=O)n1Cc1ccc(Cl)cc1 183354 US9150546, I-528::US9688643, I-528::US9718790, I-0537 P2X purinoceptor 3 Homo sapiens 53.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183354 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183354&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578907 313634754 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505125 CCOc1ccc(cc1OC)\N=c1/[nH]c(=O)n(C[C@H](C)C(=O)OC)c(=O)n1Cc1ccc(C)cc1 265566 US9718790, I-1198 P2X purinoceptor 3 Homo sapiens 35.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265566 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265566&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278313 377004439 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505126 COC(=O)c1cccc(Oc2ccc(cc2)\N=c2/[nH]c(=O)[nH]c(=O)n2Cc2ccc(Cl)cc2)c1 InChI=1S/C24H19ClN4O5/c1-33-21(30)16-3-2-4-20(13-16)34-19-11-9-18(10-12-19)26-22-27-23(31)28-24(32)29(22)14-15-5-7-17(25)8-6-15/h2-13H,14H2,1H3,(H2,26,27,28,31,32) CFMSXLDOSKUZIS-UHFFFAOYSA-N 265567 US9718790, I-1919 P2X purinoceptor 3 Homo sapiens 214 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265567 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265567&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019727 377004440 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505127 COC(=O)[C@@H](C)Cn1c(=O)nc(Nc2ccc(OC(C)C)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H27ClN4O5/c1-15(2)34-20-11-9-19(10-12-20)26-22-27-23(31)29(13-16(3)21(30)33-4)24(32)28(22)14-17-5-7-18(25)8-6-17/h5-12,15-16H,13-14H2,1-4H3,(H,26,27,31)/t16-/m0/s1 PNDUVKCLDPNYPJ-INIZCTEOSA-N 183355 US9150546, I-529::US9688643, I-529::US9718790, I-0538 P2X purinoceptor 3 Homo sapiens 22.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183355 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183355&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117900854 313634755 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505128 CCc1cc(ccc1OC(C)C)\N=c1/[nH]c(=O)n(CCC(O)=O)c(=O)n1Cc1ccc(C)cc1 InChI=1S/C25H30N4O5/c1-5-19-14-20(10-11-21(19)34-16(2)3)26-23-27-24(32)28(13-12-22(30)31)25(33)29(23)15-18-8-6-17(4)7-9-18/h6-11,14,16H,5,12-13,15H2,1-4H3,(H,30,31)(H,26,27,32) JGIHBPTWVBAMHW-UHFFFAOYSA-N 265569 US9718790, I-1199 P2X purinoceptor 3 Homo sapiens 36.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265569 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265569&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020837 377004442 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505129 OC(=O)c1cccc(Oc2ccc(cc2)\N=c2/[nH]c(=O)[nH]c(=O)n2Cc2ccc(Cl)cc2)c1 InChI=1S/C23H17ClN4O5/c24-16-6-4-14(5-7-16)13-28-21(26-22(31)27-23(28)32)25-17-8-10-18(11-9-17)33-19-3-1-2-15(12-19)20(29)30/h1-12H,13H2,(H,29,30)(H2,25,26,27,31,32) ZCBPQYNIQXHIIJ-UHFFFAOYSA-N 265570 US9718790, I-1923 P2X purinoceptor 3 Homo sapiens 84.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265570 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265570&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945573 377004443 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505130 CCOc1ccc(Nc2nc(=O)n(C[C@H](C)C(=O)OC)c(=O)n2Cc2ccc(Cl)cc2)cc1 InChI=1S/C23H25ClN4O5/c1-4-33-19-11-9-18(10-12-19)25-21-26-22(30)28(13-15(2)20(29)32-3)23(31)27(21)14-16-5-7-17(24)8-6-16/h5-12,15H,4,13-14H2,1-3H3,(H,25,26,30)/t15-/m0/s1 LLXZMQNNOVIISR-HNNXBMFYSA-N 183356 US9150546, I-530::US9688643, I-530::US9718790, I-0539 P2X purinoceptor 3 Homo sapiens 34.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183356 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183356&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 119099069 313634756 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505131 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(\C=C\C3CC3)cc2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 265572 US9718790, I-1200 P2X purinoceptor 3 Homo sapiens 45.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265572 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265572&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020832 377004445 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505132 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(c3)C(N)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H22ClN5O4/c1-2-30-24(33)29-23(31(25(30)34)15-16-6-8-18(26)9-7-16)28-19-10-12-20(13-11-19)35-21-5-3-4-17(14-21)22(27)32/h3-14H,2,15H2,1H3,(H2,27,32)(H,28,29,33) QZRKTGGZJOQIGI-UHFFFAOYSA-N 265573 US9718790, I-1925 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265573 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265573&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019724 377004446 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505133 COC(=O)[C@@H](C)Cn1c(=O)nc(Nc2ccc(OC(C)C)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H29ClN4O5/c1-15(2)35-21-11-10-20(12-16(21)3)27-23-28-24(32)30(13-17(4)22(31)34-5)25(33)29(23)14-18-6-8-19(26)9-7-18/h6-12,15,17H,13-14H2,1-5H3,(H,27,28,32)/t17-/m0/s1 GVMFNMJAZZEXOQ-KRWDZBQOSA-N 183357 US9150546, I-531::US9688643, I-531::US9718790, I-0540 P2X purinoceptor 3 Homo sapiens 10.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183357 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183357&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 119099070 313634757 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505134 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2cccc(OC)c2)n(Cc2ccc(C)cc2)c1=O 265575 US9718790, I-1201 P2X purinoceptor 3 Homo sapiens 788 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265575 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265575&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019933 377004448 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505135 Cc1cc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(CC(N)=O)c(=O)n2Cc2ccc(Cl)cc2)ccn1 InChI=1S/C24H21ClN6O4/c1-15-12-20(10-11-27-15)35-19-8-6-18(7-9-19)28-22-29-23(33)31(14-21(26)32)24(34)30(22)13-16-2-4-17(25)5-3-16/h2-12H,13-14H2,1H3,(H2,26,32)(H,28,29,33) CXTASPBPBIXBHC-UHFFFAOYSA-N 265576 US9718790, I-1926 P2X purinoceptor 3 Homo sapiens 10.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265576 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265576&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020539 377004449 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505136 CCOc1ccc(Nc2nc(=O)n(C[C@H](C)C(=O)OC)c(=O)n2Cc2ccc(Cl)cc2)cc1C InChI=1S/C24H27ClN4O5/c1-5-34-20-11-10-19(12-15(20)2)26-22-27-23(31)29(13-16(3)21(30)33-4)24(32)28(22)14-17-6-8-18(25)9-7-17/h6-12,16H,5,13-14H2,1-4H3,(H,26,27,31)/t16-/m0/s1 AHRHHAOVZLVQPW-INIZCTEOSA-N 183358 US9150546, I-532::US9688643, I-532::US9718790, I-0541 P2X purinoceptor 3 Homo sapiens 29.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183358 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183358&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 119099071 313634758 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505137 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(CCC3CC3)cc2)n(Cc2ccc(C)cc2)c1=O 265578 US9718790, I-1202 P2X purinoceptor 3 Homo sapiens 93.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265578 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265578&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945214 377004451 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505138 CNC(=O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccnc(C)c3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H23ClN6O4/c1-16-13-21(11-12-28-16)36-20-9-7-19(8-10-20)29-23-30-24(34)32(15-22(33)27-2)25(35)31(23)14-17-3-5-18(26)6-4-17/h3-13H,14-15H2,1-2H3,(H,27,33)(H,29,30,34) HJPVGKOIQSBCRR-UHFFFAOYSA-N 265579 US9718790, I-1927 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265579 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265579&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020525 377004452 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505139 CCOc1ccc(Nc2nc(=O)n(C[C@H](C)C(=O)OC)c(=O)n2Cc2ccc(Cl)cc2)cc1Cl InChI=1S/C23H24Cl2N4O5/c1-4-34-19-10-9-17(11-18(19)25)26-21-27-22(31)29(12-14(2)20(30)33-3)23(32)28(21)13-15-5-7-16(24)8-6-15/h5-11,14H,4,12-13H2,1-3H3,(H,26,27,31)/t14-/m0/s1 YDMQMBMMHSDJFG-AWEZNQCLSA-N 183359 US9150546, I-533::US9688643, I-533::US9718790, I-0542 P2X purinoceptor 3 Homo sapiens 10.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183359 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183359&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 119099072 313634759 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505140 CCCCCc1ccc(cc1)\N=c1/[nH]c(=O)n(C[C@H](C)C(=O)OC)c(=O)n1Cc1ccc(C)cc1 265581 US9718790, I-1203 P2X purinoceptor 3 Homo sapiens 532 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265581 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265581&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019893 377004454 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505141 Cc1cc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(CC(=O)NCCO)c(=O)n2Cc2ccc(Cl)cc2)ccn1 InChI=1S/C26H25ClN6O5/c1-17-14-22(10-11-28-17)38-21-8-6-20(7-9-21)30-24-31-25(36)33(16-23(35)29-12-13-34)26(37)32(24)15-18-2-4-19(27)5-3-18/h2-11,14,34H,12-13,15-16H2,1H3,(H,29,35)(H,30,31,36) AYAIJFOMDCIFHT-UHFFFAOYSA-N 265582 US9718790, I-1928 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265582 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265582&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130279125 377004455 C04080 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505142 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc3oc(C)cc3c2)n(Cc2ccc(Cl)cc2)c1=O 183360 US9150546, I-534::US9688643, I-534::US9718790, I-0543 P2X purinoceptor 3 Homo sapiens 18.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183360 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183360&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578525 313634760 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505143 CCOC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cccnc3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H24ClN5O5/c1-2-36-23(33)13-15-31-25(34)30-24(32(26(31)35)17-18-5-7-19(27)8-6-18)29-20-9-11-21(12-10-20)37-22-4-3-14-28-16-22/h3-12,14,16H,2,13,15,17H2,1H3,(H,29,30,34) ASDIBOJWVGOMLI-UHFFFAOYSA-N 265584 US9718790, I-1204 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265584 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265584&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019752 377004457 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505144 COC(=O)Cn1c(=O)[nH]\c(=N/c2ccc(OCC3CC3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H23ClN4O5/c1-32-20(29)13-28-22(30)26-21(27(23(28)31)12-15-4-6-17(24)7-5-15)25-18-8-10-19(11-9-18)33-14-16-2-3-16/h4-11,16H,2-3,12-14H2,1H3,(H,25,26,30) GQFPPAMPYDVAMW-UHFFFAOYSA-N 265585 US9718790, I-1930 P2X purinoceptor 3 Homo sapiens 29.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265585 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265585&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020523 377004458 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505145 CCOc1ccc(cc1)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 183361 US9150546, I-535::US9688643, I-535::US9718790, I-0544 P2X purinoceptor 3 Homo sapiens 52.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183361 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183361&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578651 313634761 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505146 CCOC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccncc3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H24ClN5O5/c1-2-36-23(33)13-16-31-25(34)30-24(32(26(31)35)17-18-3-5-19(27)6-4-18)29-20-7-9-21(10-8-20)37-22-11-14-28-15-12-22/h3-12,14-15H,2,13,16-17H2,1H3,(H,29,30,34) DDQSCQBHXAHRRJ-UHFFFAOYSA-N 265587 US9718790, I-1205 P2X purinoceptor 3 Homo sapiens 2.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265587 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265587&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019962 377004460 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505147 CCOC(=O)CCn1c(=O)[nH]\c(=N/c2ccc3[nH]c(C)c(C)c3c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H26ClN5O4/c1-4-35-22(32)11-12-30-24(33)29-23(31(25(30)34)14-17-5-7-18(26)8-6-17)28-19-9-10-21-20(13-19)15(2)16(3)27-21/h5-10,13,27H,4,11-12,14H2,1-3H3,(H,28,29,33) ZMSHVKLHSZHJDF-UHFFFAOYSA-N 265588 US9718790, I-1931 P2X purinoceptor 3 Homo sapiens 9.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265588 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265588&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020909 377004461 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505148 CCOc1ccc(cc1C)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 183362 US9150546, I-536::US9688643, I-536::US9718790, I-0545 P2X purinoceptor 3 Homo sapiens 46.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183362 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183362&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578788 313634762 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505149 OC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cccnc3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H20ClN5O5/c25-17-5-3-16(4-6-17)15-30-22(28-23(33)29(24(30)34)13-11-21(31)32)27-18-7-9-19(10-8-18)35-20-2-1-12-26-14-20/h1-10,12,14H,11,13,15H2,(H,31,32)(H,27,28,33) FNFPCSOZGFELPP-UHFFFAOYSA-N 265590 US9718790, I-1206 P2X purinoceptor 3 Homo sapiens 43.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265590 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265590&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021096 377004463 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505150 OC(=O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccnc(O)c3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H18ClN5O6/c24-15-3-1-14(2-4-15)12-28-21(27-22(33)29(23(28)34)13-20(31)32)26-16-5-7-17(8-6-16)35-18-9-10-25-19(30)11-18/h1-11H,12-13H2,(H,25,30)(H,31,32)(H,26,27,33) TWPXLPYCNOFWKL-UHFFFAOYSA-N 265591 US9718790, I-1932 P2X purinoceptor 3 Homo sapiens 95.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265591 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265591&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020912 377004464 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505151 CC(C)Oc1ccc(cc1)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 183363 US9150546, I-537::US9688643, I-537::US9718790, I-0546 P2X purinoceptor 3 Homo sapiens 19.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183363 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183363&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578598 313634763 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505152 OC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccncc3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H20ClN5O5/c25-17-3-1-16(2-4-17)15-30-22(28-23(33)29(24(30)34)14-11-21(31)32)27-18-5-7-19(8-6-18)35-20-9-12-26-13-10-20/h1-10,12-13H,11,14-15H2,(H,31,32)(H,27,28,33) QUFIJKPCEHWROF-UHFFFAOYSA-N 265593 US9718790, I-1207 P2X purinoceptor 3 Homo sapiens 15.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265593 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265593&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021098 377004466 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505153 Cc1ccc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(CC(O)=O)c(=O)n2Cc2ccc(Cl)cc2)cn1 InChI=1S/C24H20ClN5O5/c1-15-2-9-20(12-26-15)35-19-10-7-18(8-11-19)27-22-28-23(33)30(14-21(31)32)24(34)29(22)13-16-3-5-17(25)6-4-16/h2-12H,13-14H2,1H3,(H,31,32)(H,27,28,33) NAJYFWPAZPVKRH-UHFFFAOYSA-N 265594 US9718790, I-1934 P2X purinoceptor 3 Homo sapiens 198 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265594 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265594&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020917 377004467 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505154 CC(C)Oc1ccc(cc1C)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 183364 US9150546, I-538::US9688643, I-538::US9718790, I-0547 P2X purinoceptor 3 Homo sapiens 16.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183364 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183364&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578644 313634764 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505155 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cccnc3C)cc2)n(Cc2ccc(C)cc2)c1=O 265596 US9718790, I-1208 P2X purinoceptor 3 Homo sapiens 21.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265596 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265596&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945262 377004469 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505156 Cc1[nH]c2ccc(cc2c1C)\N=c1/[nH]c(=O)n(CC(CO)CO)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C24H26ClN5O4/c1-14-15(2)26-21-8-7-19(9-20(14)21)27-22-28-23(33)30(11-17(12-31)13-32)24(34)29(22)10-16-3-5-18(25)6-4-16/h3-9,17,26,31-32H,10-13H2,1-2H3,(H,27,28,33) WPSGYXSBEJAVIJ-UHFFFAOYSA-N 265597 US9718790, I-1935 P2X purinoceptor 3 Homo sapiens 9.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265597 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265597&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020915 377004470 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505157 CCOc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 183365 US9150546, I-539::US9688643, I-539::US9718790, I-0548 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183365 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183365&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578535 313634765 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505158 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(C)nc3)cc2)n(Cc2ccc(C)cc2)c1=O 265599 US10065941, Compound R-209::US9718790, I-1209 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265599 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265599&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021081 377004472 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506329 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(n3)C(O)=O)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H19ClFN5O5/c1-2-30-23(34)29-22(31(24(30)35)13-14-6-8-15(25)9-7-14)27-16-10-11-19(17(26)12-16)36-20-5-3-4-18(28-20)21(32)33/h3-12H,2,13H2,1H3,(H,32,33)(H,27,29,34) GFUFTCGYPUZQOI-UHFFFAOYSA-N 266763 US9718790, I-2498 P2X purinoceptor 3 Homo sapiens 3.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266763 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266763&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278638 377005634 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506330 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(n3)C(O)=O)cc2)n(C[C@H]2CC[C@H](C)CC2)c1=O 266764 US9718790, I-2499 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266764 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266764&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945426 377005635 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506331 C[C@H](C(N)=O)n1c(=O)[nH]\c(=N/c2ccc(Oc3ccon3)cc2)n(Cc2ccc(Cl)cc2)c1=O 266765 US9718790, I-2500 P2X purinoceptor 3 Homo sapiens 67.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266765 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266765&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945701 377005636 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506332 C[C@@H](C(N)=O)n1c(=O)[nH]\c(=N/c2ccc(Oc3ccon3)cc2)n(Cc2ccc(Cl)cc2)c1=O 266766 US9718790, I-2501 P2X purinoceptor 3 Homo sapiens 57.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266766 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266766&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019899 377005637 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506333 Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(n3)C(O)=O)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H17ClFN5O5/c1-29-22(33)28-21(30(23(29)34)12-13-5-7-14(24)8-6-13)26-15-9-10-18(16(25)11-15)35-19-4-2-3-17(27-19)20(31)32/h2-11H,12H2,1H3,(H,31,32)(H,26,28,33) BMBGEROQUDCMNU-UHFFFAOYSA-N 266767 US9718790, I-2502 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266767 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266767&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019664 377005638 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506334 Fc1cccc(Oc2ccc(cc2)\N=c2/[nH]c(=O)[nH]c(=O)n2Cc2ccc(Cl)cc2)n1 InChI=1S/C21H15ClFN5O3/c22-14-6-4-13(5-7-14)12-28-19(26-20(29)27-21(28)30)24-15-8-10-16(11-9-15)31-18-3-1-2-17(23)25-18/h1-11H,12H2,(H2,24,26,27,29,30) VPKFFHOKJAFQNF-UHFFFAOYSA-N 266768 US9718790, I-2503 P2X purinoceptor 3 Homo sapiens 39.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266768 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266768&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019901 377005639 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506335 OC(=O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccon3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C21H16ClN5O6/c22-14-3-1-13(2-4-14)11-26-19(24-20(30)27(21(26)31)12-18(28)29)23-15-5-7-16(8-6-15)33-17-9-10-32-25-17/h1-10H,11-12H2,(H,28,29)(H,23,24,30) MVGCEIKGSIYLCI-UHFFFAOYSA-N 266769 US9718790, I-2504 P2X purinoceptor 3 Homo sapiens 370 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266769 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266769&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945577 377005640 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506336 OCCn1c(=O)[nH]\c(=N/c2ccc(Oc3nccs3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C21H18ClN5O4S/c22-15-3-1-14(2-4-15)13-27-18(25-19(29)26(10-11-28)21(27)30)24-16-5-7-17(8-6-16)31-20-23-9-12-32-20/h1-9,12,28H,10-11,13H2,(H,24,25,29) VZPIFBDRJFNQFQ-UHFFFAOYSA-N 266770 US9718790, I-2505 P2X purinoceptor 3 Homo sapiens 17.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266770 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266770&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278371 377005641 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506337 OC[C@H](O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3nccs3)cc2)n(Cc2ccc(Cl)cc2)c1=O 266771 US9718790, I-2506 P2X purinoceptor 3 Homo sapiens 14.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266771 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266771&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278412 377005642 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506338 OCCCn1c(=O)[nH]\c(=N/c2ccc(Oc3nccs3)cc2)n(Cc2ccc(F)cc2)c1=O InChI=1S/C22H20FN5O4S/c23-16-4-2-15(3-5-16)14-28-19(26-20(30)27(22(28)31)11-1-12-29)25-17-6-8-18(9-7-17)32-21-24-10-13-33-21/h2-10,13,29H,1,11-12,14H2,(H,25,26,30) NIWPYLUMLXJFME-UHFFFAOYSA-N 266772 US9718790, I-2507 P2X purinoceptor 3 Homo sapiens 35.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266772 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266772&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278372 377005643 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506339 CC(CO)(CO)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3nccs3)cc2)n(Cc2ccc(F)cc2)c1=O InChI=1S/C24H24FN5O5S/c1-24(14-31,15-32)13-30-21(33)28-20(29(23(30)34)12-16-2-4-17(25)5-3-16)27-18-6-8-19(9-7-18)35-22-26-10-11-36-22/h2-11,31-32H,12-15H2,1H3,(H,27,28,33) WHHJYUUIIKLEKP-UHFFFAOYSA-N 266773 US9718790, I-2508 P2X purinoceptor 3 Homo sapiens 13.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266773 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266773&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020251 377005644 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506340 OCC(O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cnsn3)cc2)n(Cc2ccc(Cl)cc2)c1=O 266774 US9718790, I-2509 P2X purinoceptor 3 Homo sapiens 9.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266774 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266774&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020349 377005645 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506341 Cc1ccc(Cn2c(=O)n(C[C@H](O)CO)c(=O)[nH]\c2=N/c2ccc(Oc3ccon3)cc2)cc1 266775 US9718790, I-2510 P2X purinoceptor 3 Homo sapiens 10.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266775 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266775&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020318 377005646 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506342 Cc1nnc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(C[C@H](O)CO)c(=O)n2Cc2ccc(Cl)cc2)s1 266776 US9718790, I-2511 P2X purinoceptor 3 Homo sapiens 235 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266776 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266776&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020253 377005647 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506343 NC(=O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccon3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C21H17ClN6O5/c22-14-3-1-13(2-4-14)11-27-19(25-20(30)28(21(27)31)12-17(23)29)24-15-5-7-16(8-6-15)33-18-9-10-32-26-18/h1-10H,11-12H2,(H2,23,29)(H,24,25,30) ZIQNDJOMWVLYGM-UHFFFAOYSA-N 266777 US9718790, I-2512 P2X purinoceptor 3 Homo sapiens 11.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266777 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266777&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020285 377005648 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506344 Cc1cnc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(C[C@H](O)CO)c(=O)n2Cc2ccc(Cl)cc2)s1 266778 US9718790, I-2513 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266778 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266778&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020354 377005649 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506345 OCC(O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccsn3)cc2)n(Cc2ccc(Cl)cc2)c1=O 266779 US9718790, I-2514 P2X purinoceptor 3 Homo sapiens 11.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266779 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266779&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020346 377005650 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506346 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3nnn[nH]3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C19H17ClN8O3/c1-2-27-18(29)22-16(28(19(27)30)11-12-3-5-13(20)6-4-12)21-14-7-9-15(10-8-14)31-17-23-25-26-24-17/h3-10H,2,11H2,1H3,(H,21,22,29)(H,23,24,25,26) MWGMZKFKQVSPEE-UHFFFAOYSA-N 266780 US9718790, I-2515 P2X purinoceptor 3 Homo sapiens 346 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266780 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266780&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020347 377005651 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506347 OCCn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(F)n3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H19ClFN5O4/c24-16-6-4-15(5-7-16)14-30-21(28-22(32)29(12-13-31)23(30)33)26-17-8-10-18(11-9-17)34-20-3-1-2-19(25)27-20/h1-11,31H,12-14H2,(H,26,28,32) AWTUNBIJAYMFLU-UHFFFAOYSA-N 266781 US9718790, I-2516 P2X purinoceptor 3 Homo sapiens 9.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266781 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266781&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019805 377005652 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506348 Cc1nnc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(CC(CO)CO)c(=O)n2Cc2ccc(Cl)cc2)s1 InChI=1S/C23H23ClN6O5S/c1-14-27-28-22(36-14)35-19-8-6-18(7-9-19)25-20-26-21(33)30(11-16(12-31)13-32)23(34)29(20)10-15-2-4-17(24)5-3-15/h2-9,16,31-32H,10-13H2,1H3,(H,25,26,33) NKGPLMCQAZFETK-UHFFFAOYSA-N 266782 US9718790, I-2517 P2X purinoceptor 3 Homo sapiens 167 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266782 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266782&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019656 377005653 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506349 Cc1nsc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(C[C@H](O)CO)c(=O)n2Cc2ccc(Cl)cc2)n1 266783 US9718790, I-2518 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266783 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266783&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019657 377005654 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506350 OC[C@@H](O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ncns3)cc2)n(Cc2ccc(Cl)cc2)c1=O 266784 US9718790, I-2519 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266784 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266784&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019907 377005655 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506351 Cc1nsc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(CC(CO)CO)c(=O)n2Cc2ccc(Cl)cc2)n1 InChI=1S/C23H23ClN6O5S/c1-14-25-22(36-28-14)35-19-8-6-18(7-9-19)26-20-27-21(33)30(11-16(12-31)13-32)23(34)29(20)10-15-2-4-17(24)5-3-15/h2-9,16,31-32H,10-13H2,1H3,(H,26,27,33) BPBUTRHHJYLTDH-UHFFFAOYSA-N 266785 US9718790, I-2520 P2X purinoceptor 3 Homo sapiens 2.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266785 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266785&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020052 377005656 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506352 OCC(CO)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ncns3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C22H21ClN6O5S/c23-16-3-1-14(2-4-16)9-28-19(27-20(32)29(22(28)33)10-15(11-30)12-31)26-17-5-7-18(8-6-17)34-21-24-13-25-35-21/h1-8,13,15,30-31H,9-12H2,(H,26,27,32) IOVHMLXFMXOUKW-UHFFFAOYSA-N 266786 US9718790, I-2521 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266786 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266786&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020071 377005657 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506353 CC(C)(C)OC(=O)NCCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccon3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H27ClN6O6/c1-26(2,3)39-24(35)28-13-14-32-23(34)30-22(33(25(32)36)16-17-4-6-18(27)7-5-17)29-19-8-10-20(11-9-19)38-21-12-15-37-31-21/h4-12,15H,13-14,16H2,1-3H3,(H,28,35)(H,29,30,34) ABBVXPOCNLYWQO-UHFFFAOYSA-N 266787 US9718790, I-2522 P2X purinoceptor 3 Homo sapiens 11.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266787 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266787&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020072 377005658 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506354 NCCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccon3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C21H19ClN6O4/c22-15-3-1-14(2-4-15)13-28-19(25-20(29)27(11-10-23)21(28)30)24-16-5-7-17(8-6-16)32-18-9-12-31-26-18/h1-9,12H,10-11,13,23H2,(H,24,25,29) JGGVMLVOYUUUCO-UHFFFAOYSA-N 266788 US9718790, I-2523 P2X purinoceptor 3 Homo sapiens 169 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266788 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266788&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020099 377005659 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506355 CC(=O)NCCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccon3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H21ClN6O5/c1-15(31)25-11-12-29-22(32)27-21(30(23(29)33)14-16-2-4-17(24)5-3-16)26-18-6-8-19(9-7-18)35-20-10-13-34-28-20/h2-10,13H,11-12,14H2,1H3,(H,25,31)(H,26,27,32) GRXPELFWFMFXAZ-UHFFFAOYSA-N 266789 US9718790, I-2524 P2X purinoceptor 3 Homo sapiens 34.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266789 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266789&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020356 377005660 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506356 OC[C@H](O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(F)n3)cc2)n(Cc2ccc(Cl)cc2)c1=O 266790 US9718790, I-2525 P2X purinoceptor 3 Homo sapiens 10.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266790 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266790&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020320 377005661 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506357 CC(CO)(CO)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(F)n3)cc2)n(Cc2ccc(F)cc2)c1=O InChI=1S/C26H25F2N5O5/c1-26(15-34,16-35)14-33-24(36)31-23(32(25(33)37)13-17-5-7-18(27)8-6-17)29-19-9-11-20(12-10-19)38-22-4-2-3-21(28)30-22/h2-12,34-35H,13-16H2,1H3,(H,29,31,36) FHVIKSMXDLXQEQ-UHFFFAOYSA-N 266791 US9718790, I-2526 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266791 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266791&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020335 377005662 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506358 CNC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccon3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H21ClN6O5/c1-25-19(31)10-12-29-22(32)27-21(30(23(29)33)14-15-2-4-16(24)5-3-15)26-17-6-8-18(9-7-17)35-20-11-13-34-28-20/h2-9,11,13H,10,12,14H2,1H3,(H,25,31)(H,26,27,32) GVIMTWWVBWTXBL-UHFFFAOYSA-N 266792 US9718790, I-2527 P2X purinoceptor 3 Homo sapiens 26.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266792 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266792&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020322 377005663 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506359 OCC(CO)n1c(=O)[nH]\c(=N/c2ccc(Oc3ccon3)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C22H19ClFN5O6/c23-14-3-1-13(2-4-14)10-28-20(26-21(32)29(22(28)33)16(11-30)12-31)25-15-5-6-18(17(24)9-15)35-19-7-8-34-27-19/h1-9,16,30-31H,10-12H2,(H,25,26,32) JEWOFLVKLCRTQK-UHFFFAOYSA-N 266793 US9718790, I-2529 P2X purinoceptor 3 Homo sapiens 73.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266793 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266793&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019855 377005664 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506360 OC[C@@H](O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccsn3)cc2)n(Cc2ccc(Cl)cc2)c1=O 266794 US9718790, I-2530 P2X purinoceptor 3 Homo sapiens 16.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266794 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266794&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019830 377005665 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506361 CC(CO)(CO)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccsn3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H24ClN5O5S/c1-24(14-31,15-32)13-30-22(33)27-21(29(23(30)34)12-16-2-4-17(25)5-3-16)26-18-6-8-19(9-7-18)35-20-10-11-36-28-20/h2-11,31-32H,12-15H2,1H3,(H,26,27,33) KMCKUPADQMZOCV-UHFFFAOYSA-N 266795 US9718790, I-2531 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266795 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266795&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019747 377005666 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506362 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccnc(n3)C(N)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H20ClN7O4/c1-2-30-22(33)29-21(31(23(30)34)13-14-3-5-15(24)6-4-14)27-16-7-9-17(10-8-16)35-18-11-12-26-20(28-18)19(25)32/h3-12H,2,13H2,1H3,(H2,25,32)(H,27,29,33) CYSOISJVAJPUKG-UHFFFAOYSA-N 266796 US9718790, I-2532 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266796 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266796&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 56655626 377005667 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506363 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(nn3)C(=O)NC)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H22ClN7O4/c1-3-31-23(34)28-22(32(24(31)35)14-15-4-6-16(25)7-5-15)27-17-8-10-18(11-9-17)36-20-13-12-19(29-30-20)21(33)26-2/h4-13H,3,14H2,1-2H3,(H,26,33)(H,27,28,34) QHFQCYIQKPEOKX-UHFFFAOYSA-N 266797 US9718790, I-2533 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266797 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266797&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019825 377005668 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506364 CNC(=O)[C@@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3ccon3)cc2)n(Cc2ccc(Cl)cc2)c1=O 266798 US9718790, I-2534 P2X purinoceptor 3 Homo sapiens 105 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266798 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266798&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130279140 377005669 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506365 CNC(=O)[C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3ccon3)cc2)n(Cc2ccc(Cl)cc2)c1=O 266799 US9718790, I-2535 P2X purinoceptor 3 Homo sapiens 44.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266799 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266799&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019644 377005670 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506366 COCCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccnc(c3)C(=O)OC)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H24ClN5O6/c1-36-14-13-31-25(34)30-24(32(26(31)35)16-17-3-5-18(27)6-4-17)29-19-7-9-20(10-8-19)38-21-11-12-28-22(15-21)23(33)37-2/h3-12,15H,13-14,16H2,1-2H3,(H,29,30,34) HEBYERXHBYYMSJ-UHFFFAOYSA-N 266800 US9718790, I-2536 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266800 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266800&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278443 377005671 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506367 COCCn1c(=O)[nH]\c(=N/c2ccc(Oc3cncc(c3)C(=O)OC)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H24ClN5O6/c1-36-12-11-31-25(34)30-24(32(26(31)35)16-17-3-5-19(27)6-4-17)29-20-7-9-21(10-8-20)38-22-13-18(14-28-15-22)23(33)37-2/h3-10,13-15H,11-12,16H2,1-2H3,(H,29,30,34) NUGCBUGKYGYTOY-UHFFFAOYSA-N 266801 US9718790, I-2537 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266801 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266801&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945449 377005672 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506368 COCCn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(n3)C#N)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H21ClN6O4/c1-35-14-13-31-24(33)30-23(32(25(31)34)16-17-5-7-18(26)8-6-17)29-19-9-11-21(12-10-19)36-22-4-2-3-20(15-27)28-22/h2-12H,13-14,16H2,1H3,(H,29,30,33) PHZGTCYGTZLOFX-UHFFFAOYSA-N 266802 US9718790, I-2538 P2X purinoceptor 3 Homo sapiens 3.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266802 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266802&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945689 377005673 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506369 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(n3)C#N)cc2)n(Cc2ncc(Cl)cn2)c1=O InChI=1S/C22H17ClN8O3/c1-2-30-21(32)29-20(31(22(30)33)13-18-25-11-14(23)12-26-18)28-15-6-8-17(9-7-15)34-19-5-3-4-16(10-24)27-19/h3-9,11-12H,2,13H2,1H3,(H,28,29,32) HKOLWAYZBHBZIJ-UHFFFAOYSA-N 266803 US9718790, I-2539 P2X purinoceptor 3 Homo sapiens 76.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266803 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266803&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945683 377005674 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506370 CCOC(=O)CN(C(=O)OC(C)(C)C)c1cc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(CC)c(=O)n2Cc2ccc(Cl)cc2)ccn1 InChI=1S/C32H35ClN6O7/c1-6-37-29(41)36-28(39(30(37)42)19-21-8-10-22(33)11-9-21)35-23-12-14-24(15-13-23)45-25-16-17-34-26(18-25)38(20-27(40)44-7-2)31(43)46-32(3,4)5/h8-18H,6-7,19-20H2,1-5H3,(H,35,36,41) APVVRWAEUAQEMP-UHFFFAOYSA-N 266804 US9718790, I-2540 P2X purinoceptor 3 Homo sapiens 104 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266804 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266804&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019905 377005675 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506371 OCC(CO)n1c(=O)[nH]\c(=N/c2ccc(Oc3nccs3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C22H20ClN5O5S/c23-15-3-1-14(2-4-15)11-27-19(26-20(31)28(22(27)32)17(12-29)13-30)25-16-5-7-18(8-6-16)33-21-24-9-10-34-21/h1-10,17,29-30H,11-13H2,(H,25,26,31) HSHBAJKXCDOXRB-UHFFFAOYSA-N 266805 US9718790, I-2541 P2X purinoceptor 3 Homo sapiens 118 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266805 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266805&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019748 377005676 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506372 OCC(CO)n1c(=O)[nH]\c(=N/c2ccc(Oc3ccon3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C22H20ClN5O6/c23-15-3-1-14(2-4-15)11-27-20(25-21(31)28(22(27)32)17(12-29)13-30)24-16-5-7-18(8-6-16)34-19-9-10-33-26-19/h1-10,17,29-30H,11-13H2,(H,24,25,31) HTEDDIKCQWQSQR-UHFFFAOYSA-N 266806 US9718790, I-2542 P2X purinoceptor 3 Homo sapiens 186 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266806 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266806&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019906 377005677 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506373 OCCCn1c(=O)[nH]\c(=N/c2ccc(Oc3ncccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H21ClN6O4/c24-17-5-3-16(4-6-17)15-30-20(28-22(32)29(23(30)33)13-2-14-31)27-18-7-9-19(10-8-18)34-21-25-11-1-12-26-21/h1,3-12,31H,2,13-15H2,(H,27,28,32) RSMRIGIKNNRUTJ-UHFFFAOYSA-N 266807 US9718790, I-2543 P2X purinoceptor 3 Homo sapiens 10.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266807 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266807&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019812 377005678 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506374 OCC(CO)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ncccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H23ClN6O5/c25-18-4-2-16(3-5-18)12-30-21(29-23(34)31(24(30)35)13-17(14-32)15-33)28-19-6-8-20(9-7-19)36-22-26-10-1-11-27-22/h1-11,17,32-33H,12-15H2,(H,28,29,34) OXBILDKBFJTYHD-UHFFFAOYSA-N 266808 US9718790, I-2544 P2X purinoceptor 3 Homo sapiens 11.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266808 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266808&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020259 377005679 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506375 OCCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(cc3)C#N)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H20ClN5O4/c26-19-5-1-18(2-6-19)16-31-23(29-24(33)30(13-14-32)25(31)34)28-20-7-11-22(12-8-20)35-21-9-3-17(15-27)4-10-21/h1-12,32H,13-14,16H2,(H,28,29,33) HJZIAGAYCAIBBH-UHFFFAOYSA-N 266809 US9718790, I-2545 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266809 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266809&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945715 377005680 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506376 NC(=O)c1ccc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(C[C@H](O)CO)c(=O)n2Cc2ccc(Cl)cc2)cc1 266810 US9718790, I-2546 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266810 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266810&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945688 377005681 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506377 COCCn1c(=O)[nH]\c(=N/c2ccc(Oc3cncc(c3)C(O)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H22ClN5O6/c1-36-11-10-30-24(34)29-23(31(25(30)35)15-16-2-4-18(26)5-3-16)28-19-6-8-20(9-7-19)37-21-12-17(22(32)33)13-27-14-21/h2-9,12-14H,10-11,15H2,1H3,(H,32,33)(H,28,29,34) VFZDKJLHHPPGBT-UHFFFAOYSA-N 266811 US9718790, I-2547 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266811 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266811&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020321 377005682 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506378 COCCn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(n3)C(O)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H22ClN5O6/c1-36-14-13-30-24(34)29-23(31(25(30)35)15-16-5-7-17(26)8-6-16)27-18-9-11-19(12-10-18)37-21-4-2-3-20(28-21)22(32)33/h2-12H,13-15H2,1H3,(H,32,33)(H,27,29,34) PWAMGCLKGLTSJZ-UHFFFAOYSA-N 266812 US9718790, I-2548 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266812 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266812&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020234 377005683 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506379 CCOC(=O)CNc1cc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(CC)c(=O)n2Cc2ccc(Cl)cc2)ccn1 InChI=1S/C27H27ClN6O5/c1-3-33-26(36)32-25(34(27(33)37)17-18-5-7-19(28)8-6-18)31-20-9-11-21(12-10-20)39-22-13-14-29-23(15-22)30-16-24(35)38-4-2/h5-15H,3-4,16-17H2,1-2H3,(H,29,30)(H,31,32,36) RVBUGJHTFXJVLM-UHFFFAOYSA-N 266813 US9718790, I-2549 P2X purinoceptor 3 Homo sapiens 12.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266813 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266813&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020282 377005684 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506380 CCOC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ncccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H23ClN6O5/c1-2-36-21(33)12-15-31-24(34)30-22(32(25(31)35)16-17-4-6-18(26)7-5-17)29-19-8-10-20(11-9-19)37-23-27-13-3-14-28-23/h3-11,13-14H,2,12,15-16H2,1H3,(H,29,30,34) PVNFXIUWMAKDNO-UHFFFAOYSA-N 266814 US9718790, I-2550 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266814 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266814&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020283 377005685 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506381 COC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ncccn3)cc2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C25H24N6O5/c1-17-4-6-18(7-5-17)16-31-22(29-24(33)30(25(31)34)15-12-21(32)35-2)28-19-8-10-20(11-9-19)36-23-26-13-3-14-27-23/h3-11,13-14H,12,15-16H2,1-2H3,(H,28,29,33) CLACDTUTYIJNKS-UHFFFAOYSA-N 266815 US9718790, I-2551 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266815 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266815&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020334 377005686 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506382 COCCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccnc(c3)C(O)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H22ClN5O6/c1-36-13-12-30-24(34)29-23(31(25(30)35)15-16-2-4-17(26)5-3-16)28-18-6-8-19(9-7-18)37-20-10-11-27-21(14-20)22(32)33/h2-11,14H,12-13,15H2,1H3,(H,32,33)(H,28,29,34) CDHQTSMVLXRQKG-UHFFFAOYSA-N 266816 US9718790, I-2552 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266816 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266816&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021111 377005687 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506383 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(n3)C(O)=O)cc2)n(Cc2ncc(Cl)cn2)c1=O InChI=1S/C22H18ClN7O5/c1-2-29-21(33)28-20(30(22(29)34)12-17-24-10-13(23)11-25-17)26-14-6-8-15(9-7-14)35-18-5-3-4-16(27-18)19(31)32/h3-11H,2,12H2,1H3,(H,31,32)(H,26,28,33) MQFSUXFHGXHSMM-UHFFFAOYSA-N 266817 US9718790, I-2553 P2X purinoceptor 3 Homo sapiens 216 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266817 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266817&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021101 377005688 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506384 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccnc(NCC(N)=O)c3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H24ClN7O4/c1-2-32-24(35)31-23(33(25(32)36)15-16-3-5-17(26)6-4-16)30-18-7-9-19(10-8-18)37-20-11-12-28-22(13-20)29-14-21(27)34/h3-13H,2,14-15H2,1H3,(H2,27,34)(H,28,29)(H,30,31,35) KPWCGUCKYHOBQX-UHFFFAOYSA-N 266818 US9718790, I-2554 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266818 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266818&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278417 377005689 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506385 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccnc(NCC(=O)NC)c3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H26ClN7O4/c1-3-33-25(36)32-24(34(26(33)37)16-17-4-6-18(27)7-5-17)31-19-8-10-20(11-9-19)38-21-12-13-29-22(14-21)30-15-23(35)28-2/h4-14H,3,15-16H2,1-2H3,(H,28,35)(H,29,30)(H,31,32,36) VPUVLGSGFHDUGB-UHFFFAOYSA-N 266819 US9718790, I-2555 P2X purinoceptor 3 Homo sapiens 16.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266819 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266819&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021156 377005690 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506386 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccnc(NCC(O)=O)c3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H23ClN6O5/c1-2-31-24(35)30-23(32(25(31)36)15-16-3-5-17(26)6-4-16)29-18-7-9-19(10-8-18)37-20-11-12-27-21(13-20)28-14-22(33)34/h3-13H,2,14-15H2,1H3,(H,27,28)(H,33,34)(H,29,30,35) HQFLFNUBPSNNHP-UHFFFAOYSA-N 266820 US9718790, I-2556 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266820 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266820&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020589 377005691 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506387 OC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ncccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H19ClN6O5/c24-16-4-2-15(3-5-16)14-30-20(28-22(33)29(23(30)34)13-10-19(31)32)27-17-6-8-18(9-7-17)35-21-25-11-1-12-26-21/h1-9,11-12H,10,13-14H2,(H,31,32)(H,27,28,33) SEZCMQSZUCXHJX-UHFFFAOYSA-N 266821 US9718790, I-2557 P2X purinoceptor 3 Homo sapiens 19.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266821 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266821&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020659 377005692 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506388 Cc1ccc(Cn2c(=O)n(CCC(O)=O)c(=O)[nH]\c2=N/c2ccc(Oc3ncccn3)cc2)cc1 InChI=1S/C24H22N6O5/c1-16-3-5-17(6-4-16)15-30-21(28-23(33)29(24(30)34)14-11-20(31)32)27-18-7-9-19(10-8-18)35-22-25-12-2-13-26-22/h2-10,12-13H,11,14-15H2,1H3,(H,31,32)(H,27,28,33) MSXSUTXTMCAUDY-UHFFFAOYSA-N 266822 US9718790, I-2558 P2X purinoceptor 3 Homo sapiens 22.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266822 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266822&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020660 377005693 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506389 NC(=O)c1ccc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(CCO)c(=O)n2Cc2ccc(Cl)cc2)cc1 InChI=1S/C25H22ClN5O5/c26-18-5-1-16(2-6-18)15-31-23(29-24(34)30(13-14-32)25(31)35)28-19-7-11-21(12-8-19)36-20-9-3-17(4-10-20)22(27)33/h1-12,32H,13-15H2,(H2,27,33)(H,28,29,34) PKVBDFAHNWAVFP-UHFFFAOYSA-N 266823 US9718790, I-2559 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266823 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266823&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278252 377005694 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506390 OC[C@H](O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(cc3)C#N)cc2)n(Cc2ccc(Cl)cc2)c1=O 266824 US9718790, I-2560 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266824 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266824&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278444 377005695 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506392 CCOC(=O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(F)n3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H21ClFN5O5/c1-2-36-22(33)15-32-24(34)30-23(31(25(32)35)14-16-6-8-17(26)9-7-16)28-18-10-12-19(13-11-18)37-21-5-3-4-20(27)29-21/h3-13H,2,14-15H2,1H3,(H,28,30,34) ZOISEQWZWDMNJI-UHFFFAOYSA-N 266825 US9718790, I-2562 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266825 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266825&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278374 377005696 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506393 OCCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccsn3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C21H18ClN5O4S/c22-15-3-1-14(2-4-15)13-27-19(24-20(29)26(10-11-28)21(27)30)23-16-5-7-17(8-6-16)31-18-9-12-32-25-18/h1-9,12,28H,10-11,13H2,(H,23,24,29) MFWRBURBIDYOAF-UHFFFAOYSA-N 266826 US9718790, I-2563 P2X purinoceptor 3 Homo sapiens 15.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266826 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266826&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020588 377005697 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506394 OC(=O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(F)n3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H17ClFN5O5/c24-15-6-4-14(5-7-15)12-29-21(28-22(33)30(23(29)34)13-20(31)32)26-16-8-10-17(11-9-16)35-19-3-1-2-18(25)27-19/h1-11H,12-13H2,(H,31,32)(H,26,28,33) FFSVUKMVDYCXAB-UHFFFAOYSA-N 266827 US9718790, I-2564 P2X purinoceptor 3 Homo sapiens 269 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266827 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266827&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278665 377005698 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506395 NC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ncccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H20ClN7O4/c24-16-4-2-15(3-5-16)14-31-20(29-22(33)30(23(31)34)13-10-19(25)32)28-17-6-8-18(9-7-17)35-21-26-11-1-12-27-21/h1-9,11-12H,10,13-14H2,(H2,25,32)(H,28,29,33) FFUJKHYKPARNEJ-UHFFFAOYSA-N 266828 US9718790, I-2565 P2X purinoceptor 3 Homo sapiens 17.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266828 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266828&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278375 377005699 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504666 CC[C@@H](C)Oc1ccc(cc1C)\N=c1/[nH]c(=O)n(CCC(O)=O)c(=O)n1Cc1ccc(C)cc1 265114 US9718790, I-1029 P2X purinoceptor 3 Homo sapiens 35.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265114 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265114&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945042 377003990 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504667 Oc1cc(Oc2ccc(cc2)\N=c2/[nH]c(=O)[nH]c(=O)n2Cc2ccc(Cl)cc2)ccn1 InChI=1S/C21H16ClN5O4/c22-14-3-1-13(2-4-14)12-27-19(25-20(29)26-21(27)30)24-15-5-7-16(8-6-15)31-17-9-10-23-18(28)11-17/h1-11H,12H2,(H,23,28)(H2,24,25,26,29,30) BRDBXNLFWSIYQP-UHFFFAOYSA-N 265115 US9718790, I-1715 P2X purinoceptor 3 Homo sapiens 21.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265115 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265115&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945272 377003991 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504668 CC(C)Cc1ccc(Nc2nc(=O)n(CC(CO)CO)c(=O)n2Cc2ccc(Cl)cc2)cc1 InChI=1S/C24H29ClN4O4/c1-16(2)11-17-5-9-21(10-6-17)26-22-27-23(32)29(13-19(14-30)15-31)24(33)28(22)12-18-3-7-20(25)8-4-18/h3-10,16,19,30-31H,11-15H2,1-2H3,(H,26,27,32) DKYDIWXEJZFVMN-UHFFFAOYSA-N 183202 US9150546, I-366::US9688643, I-366::US9718790, I-0366 P2X purinoceptor 3 Homo sapiens 46.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183202 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183202&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821182 313634602 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504669 CC[C@@H](C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(CCC(O)=O)c(=O)n1Cc1ccc(C)cc1 265117 US9718790, I-1030 P2X purinoceptor 3 Homo sapiens 14.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265117 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265117&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278173 377003993 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504670 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccnc(c3)C(=O)NC)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H23ClN6O4/c1-3-31-24(34)30-23(32(25(31)35)15-16-4-6-17(26)7-5-16)29-18-8-10-19(11-9-18)36-20-12-13-28-21(14-20)22(33)27-2/h4-14H,3,15H2,1-2H3,(H,27,33)(H,29,30,34) IMIAZSYJRAXFLG-UHFFFAOYSA-N 265118 US9718790, I-1717 P2X purinoceptor 3 Homo sapiens 2.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265118 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265118&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945210 377003994 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504671 OCC(CO)Cn1c(=O)nc(Nc2cccc(c2)C(F)(F)F)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C21H20ClF3N4O4/c22-16-6-4-13(5-7-16)9-28-18(26-17-3-1-2-15(8-17)21(23,24)25)27-19(32)29(20(28)33)10-14(11-30)12-31/h1-8,14,30-31H,9-12H2,(H,26,27,32) KCPABKMRFNAYPP-UHFFFAOYSA-N 183203 US9150546, I-367::US9688643, I-367::US9718790, I-0367 P2X purinoceptor 3 Homo sapiens 40.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183203 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183203&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821236 313634603 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504672 C[C@@H](Oc1ccc(cc1)\N=c1/[nH]c(=O)n(CCC(O)=O)c(=O)n1Cc1ccc(C)cc1)C(F)(F)F 265120 US9718790, I-1031 P2X purinoceptor 3 Homo sapiens 64.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265120 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265120&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019568 377003996 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504673 Cc1ccc(Cn2c(=O)n(CCC(O)=O)c(=O)[nH]\c2=N/c2ncc(s2)-c2ccccc2)cc1 InChI=1S/C23H21N5O4S/c1-15-7-9-16(10-8-15)14-28-20(26-22(31)27(23(28)32)12-11-19(29)30)25-21-24-13-18(33-21)17-5-3-2-4-6-17/h2-10,13H,11-12,14H2,1H3,(H,29,30)(H,24,25,26,31) IKBWTPRONTWAQN-UHFFFAOYSA-N 265121 US9718790, I-1725 P2X purinoceptor 3 Homo sapiens 953 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265121 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265121&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021053 377003997 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504674 CC(C)Oc1ccc(Nc2nc(=O)n(CC(CO)CO)c(=O)n2Cc2ccc(Cl)cc2)cc1 InChI=1S/C23H27ClN4O5/c1-15(2)33-20-9-7-19(8-10-20)25-21-26-22(31)28(12-17(13-29)14-30)23(32)27(21)11-16-3-5-18(24)6-4-16/h3-10,15,17,29-30H,11-14H2,1-2H3,(H,25,26,31) RWDNKWAXZYGNOK-UHFFFAOYSA-N 183204 US9150546, I-368::US9688643, I-368::US9718790, I-0368 P2X purinoceptor 3 Homo sapiens 41.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183204 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183204&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821424 313634604 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504675 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(OC(F)F)c(Cl)c2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 265123 US9718790, I-1032 P2X purinoceptor 3 Homo sapiens 33.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265123 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265123&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019595 377003999 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504676 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n(CCC(O)=O)c(=O)n1CCC1C[C@H]2CC[C@@H]1C2 265124 US9718790, I-1729 P2X purinoceptor 3 Homo sapiens 669 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265124 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265124&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278362 377004000 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504677 CC(C)Oc1ccc(Nc2nc(=O)n(CC(CO)CO)c(=O)n2Cc2ccc(Cl)cc2)cc1Cl InChI=1S/C23H26Cl2N4O5/c1-14(2)34-20-8-7-18(9-19(20)25)26-21-27-22(32)29(11-16(12-30)13-31)23(33)28(21)10-15-3-5-17(24)6-4-15/h3-9,14,16,30-31H,10-13H2,1-2H3,(H,26,27,32) PLKBMAZPUXNVOD-UHFFFAOYSA-N 183205 US9150546, I-369::US9688643, I-369::US9718790, I-0369 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183205 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183205&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821090 313634605 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504678 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(OC(F)(F)F)c(Cl)c2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 265126 US9718790, I-1033 P2X purinoceptor 3 Homo sapiens 67.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265126 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265126&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019596 377004002 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504679 OC[C@@H](O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccnc(O)c3)cc2)n(Cc2ccc(Cl)cc2)c1=O 265127 US9718790, I-1731 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265127 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265127&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278596 377004003 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504680 OCC(CO)Cn1c(=O)nc(Nc2ccc(OC(F)F)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C21H21ClF2N4O5/c22-15-3-1-13(2-4-15)9-27-19(25-16-5-7-17(8-6-16)33-18(23)24)26-20(31)28(21(27)32)10-14(11-29)12-30/h1-8,14,18,29-30H,9-12H2,(H,25,26,31) ZMQLRXDQQRWLTK-UHFFFAOYSA-N 183206 US9150546, I-370::US9688643, I-370::US9718790, I-0370 P2X purinoceptor 3 Homo sapiens 154 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183206 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183206&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821298 313634606 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504681 CCCOc1ccc(cc1)\N=c1/[nH]c(=O)n(C[C@@H](C)C(=O)OC)c(=O)n1Cc1ccc(Cl)cc1 265129 US9718790, I-1034 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265129 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265129&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019716 377004005 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504682 COc1ccc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(CCO)c(=O)n2Cc2ccc(Cl)cc2)cn1 InChI=1S/C24H22ClN5O5/c1-34-21-11-10-20(14-26-21)35-19-8-6-18(7-9-19)27-22-28-23(32)29(12-13-31)24(33)30(22)15-16-2-4-17(25)5-3-16/h2-11,14,31H,12-13,15H2,1H3,(H,27,28,32) QDPPXUGCVVTIMM-UHFFFAOYSA-N 265130 US9718790, I-1732 P2X purinoceptor 3 Homo sapiens 11.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265130 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265130&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945625 377004006 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504683 CCOc1ccc(Nc2nc(=O)n(CC(CO)CO)c(=O)n2Cc2ccc(Cl)cc2)cc1 InChI=1S/C22H25ClN4O5/c1-2-32-19-9-7-18(8-10-19)24-20-25-21(30)27(12-16(13-28)14-29)22(31)26(20)11-15-3-5-17(23)6-4-15/h3-10,16,28-29H,2,11-14H2,1H3,(H,24,25,30) YVGBOPHKOBITOP-UHFFFAOYSA-N 183207 US9150546, I-371::US9688643, I-371::US9718790, I-0371 P2X purinoceptor 3 Homo sapiens 63.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183207 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183207&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821436 313634607 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504684 CCCOc1ccc(cc1)\N=c1/[nH]c(=O)n(C[C@@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 265132 US9718790, I-1035 P2X purinoceptor 3 Homo sapiens 65.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265132 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265132&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945047 377004008 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504685 COc1ccc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(CCCO)c(=O)n2Cc2ccc(Cl)cc2)cn1 InChI=1S/C25H24ClN5O5/c1-35-22-12-11-21(15-27-22)36-20-9-7-19(8-10-20)28-23-29-24(33)30(13-2-14-32)25(34)31(23)16-17-3-5-18(26)6-4-17/h3-12,15,32H,2,13-14,16H2,1H3,(H,28,29,33) YYKBVSXPTFCNPH-UHFFFAOYSA-N 265133 US9718790, I-1733 P2X purinoceptor 3 Homo sapiens 3.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265133 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265133&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278286 377004009 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504686 CC(C)n1c(=O)nc(Nc2ccc(cc2)C#N)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C20H18ClN5O2/c1-13(2)26-19(27)24-18(23-17-9-5-14(11-22)6-10-17)25(20(26)28)12-15-3-7-16(21)8-4-15/h3-10,13H,12H2,1-2H3,(H,23,24,27) NZRBAYNKFGYVJA-UHFFFAOYSA-N 183208 US9150546, I-372::US9688643, I-372::US9718790, I-0372 P2X purinoceptor 3 Homo sapiens 964 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183208 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183208&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821062 313634608 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504687 COC(=O)[C@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(OCC3CC3)cc2)n(Cc2ccc(Cl)cc2)c1=O 265135 US9718790, I-1036 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265135 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265135&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945081 377004011 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504688 COc1ccc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(C[C@H](O)CO)c(=O)n2Cc2ccc(Cl)cc2)cn1 265136 US9718790, I-1734 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265136 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265136&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278201 377004012 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504689 OCCn1c(=O)nc(Nc2ccc(Cl)c(Cl)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C18H15Cl3N4O3/c19-12-3-1-11(2-4-12)10-25-16(22-13-5-6-14(20)15(21)9-13)23-17(27)24(7-8-26)18(25)28/h1-6,9,26H,7-8,10H2,(H,22,23,27) TYTCSKQWLRQJSW-UHFFFAOYSA-N 183209 US9150546, I-373::US9688643, I-373::US9718790, I-0373 P2X purinoceptor 3 Homo sapiens 185 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183209 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183209&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821272 313634609 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504690 C[C@H](Cn1c(=O)[nH]\c(=N/c2ccc(OCC3CC3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 265138 US9718790, I-1037 P2X purinoceptor 3 Homo sapiens 93.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265138 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265138&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945250 377004014 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504691 CNC(=O)c1cc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(CCO)c(=O)n2Cc2ccc(Cl)cc2)ccn1 InChI=1S/C25H23ClN6O5/c1-27-22(34)21-14-20(10-11-28-21)37-19-8-6-18(7-9-19)29-23-30-24(35)31(12-13-33)25(36)32(23)15-16-2-4-17(26)5-3-16/h2-11,14,33H,12-13,15H2,1H3,(H,27,34)(H,29,30,35) JYIMUFKODXMQCD-UHFFFAOYSA-N 265139 US9718790, I-1735 P2X purinoceptor 3 Homo sapiens 3.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265139 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265139&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945544 377004015 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504692 OCCn1c(=O)nc(Nc2ccc(OC3CCCC3)c(Cl)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H24Cl2N4O4/c24-16-7-5-15(6-8-16)14-29-21(27-22(31)28(11-12-30)23(29)32)26-17-9-10-20(19(25)13-17)33-18-3-1-2-4-18/h5-10,13,18,30H,1-4,11-12,14H2,(H,26,27,31) DLYUERWZMWXDRU-UHFFFAOYSA-N 183210 US9150546, I-374::US9688643, I-374::US9718790, I-0374 P2X purinoceptor 3 Homo sapiens 80.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183210 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183210&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821239 313634610 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504693 CCCOc1ccc(cc1)\N=c1/[nH]c(=O)n(C[C@@H](CC)C(=O)OC)c(=O)n1Cc1ccc(Cl)cc1 265141 US9718790, I-1038 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265141 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265141&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945157 377004017 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504694 Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccnc(O)c3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C22H18ClN5O4/c1-27-21(30)26-20(28(22(27)31)13-14-2-4-15(23)5-3-14)25-16-6-8-17(9-7-16)32-18-10-11-24-19(29)12-18/h2-12H,13H2,1H3,(H,24,29)(H,25,26,30) KHJNTCHVJDFAFF-UHFFFAOYSA-N 265142 US9718790, I-1736 P2X purinoceptor 3 Homo sapiens 9.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265142 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265142&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020540 377004018 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504695 OCCn1c(=O)nc(Nc2ccc(OC(F)F)c(Cl)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C19H16Cl2F2N4O4/c20-12-3-1-11(2-4-12)10-27-17(25-18(29)26(7-8-28)19(27)30)24-13-5-6-15(14(21)9-13)31-16(22)23/h1-6,9,16,28H,7-8,10H2,(H,24,25,29) YCBOZBOYAOUFQO-UHFFFAOYSA-N 183211 US9150546, I-375::US9688643, I-375::US9718790, I-0375 P2X purinoceptor 3 Homo sapiens 152 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183211 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183211&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821378 313634611 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504696 CCCOc1ccc(cc1)\N=c1/[nH]c(=O)n(C[C@@H](CC)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 265144 US9718790, I-1039 P2X purinoceptor 3 Homo sapiens 83.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265144 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265144&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945032 377004020 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504697 Cc1nc2ccc(cc2s1)\N=c1/[nH]c(=O)n(C)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C19H16ClN5O2S/c1-11-21-15-8-7-14(9-16(15)28-11)22-17-23-18(26)24(2)19(27)25(17)10-12-3-5-13(20)6-4-12/h3-9H,10H2,1-2H3,(H,22,23,26) URYGGFRLDSNUBS-UHFFFAOYSA-N 265145 US9718790, I-1737 P2X purinoceptor 3 Homo sapiens 19.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265145 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265145&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020541 377004021 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504698 CS(=O)(=O)Nc1ccc(Nc2nc(=O)n(CCO)c(=O)n2Cc2ccc(Cl)cc2)cc1 InChI=1S/C19H20ClN5O5S/c1-31(29,30)23-16-8-6-15(7-9-16)21-17-22-18(27)24(10-11-26)19(28)25(17)12-13-2-4-14(20)5-3-13/h2-9,23,26H,10-12H2,1H3,(H,21,22,27) GOQQKNNSEKHBIT-UHFFFAOYSA-N 183212 US9150546, I-377::US9718790, I-0377 P2X purinoceptor 3 Homo sapiens 755 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183212 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183212&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 77388326 313634612 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504699 CCSc1ccc(cc1C)\N=c1/[nH]c(=O)n(C[C@H](C)C(=O)OC)c(=O)n1Cc1ccc(Cl)cc1 265147 US9718790, I-1040 P2X purinoceptor 3 Homo sapiens 128 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265147 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265147&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020246 377004023 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504700 CCc1nc2ccc(cc2s1)\N=c1/[nH]c(=O)n(CCC(=O)NC)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C23H23ClN6O3S/c1-3-20-27-17-9-8-16(12-18(17)34-20)26-21-28-22(32)29(11-10-19(31)25-2)23(33)30(21)13-14-4-6-15(24)7-5-14/h4-9,12H,3,10-11,13H2,1-2H3,(H,25,31)(H,26,28,32) UCXABSRALDGTQN-UHFFFAOYSA-N 265148 US9718790, I-1738 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265148 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265148&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020470 377004024 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504701 CC(C)c1cccc(Nc2nc(=O)n(CCO)c(=O)n2Cc2ccc(Cl)cc2)c1 InChI=1S/C21H23ClN4O3/c1-14(2)16-4-3-5-18(12-16)23-19-24-20(28)25(10-11-27)21(29)26(19)13-15-6-8-17(22)9-7-15/h3-9,12,14,27H,10-11,13H2,1-2H3,(H,23,24,28) HHUYYWJOWGZXNS-UHFFFAOYSA-N 183213 US9150546, I-378::US9688643, I-378::US9718790, I-0378 P2X purinoceptor 3 Homo sapiens 347 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183213 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183213&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821174 313634613 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504702 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(C#CC3CC3)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O 265150 US9718790, I-1041 P2X purinoceptor 3 Homo sapiens 101 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265150 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265150&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020826 377004026 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504703 CCc1nc2ccc(cc2s1)\N=c1/[nH]c(=O)n(CCC(=O)NCCO)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C24H25ClN6O4S/c1-2-21-28-18-8-7-17(13-19(18)36-21)27-22-29-23(34)30(11-9-20(33)26-10-12-32)24(35)31(22)14-15-3-5-16(25)6-4-15/h3-8,13,32H,2,9-12,14H2,1H3,(H,26,33)(H,27,29,34) CLCCCGMJLUJFPJ-UHFFFAOYSA-N 265151 US9718790, I-1739 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265151 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265151&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020542 377004027 C04080 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504704 CCCSc1ccc(Nc2nc(=O)n(CCO)c(=O)n2Cc2ccc(Cl)cc2)cc1 InChI=1S/C21H23ClN4O3S/c1-2-13-30-18-9-7-17(8-10-18)23-19-24-20(28)25(11-12-27)21(29)26(19)14-15-3-5-16(22)6-4-15/h3-10,27H,2,11-14H2,1H3,(H,23,24,28) WSXYIBMUMGPQNK-UHFFFAOYSA-N 183214 US9150546, I-379::US9688643, I-379::US9718790, I-0379 P2X purinoceptor 3 Homo sapiens 330 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183214 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183214&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821173 313634614 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504705 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(C#CC3CC3)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 265153 US9718790, I-1042 P2X purinoceptor 3 Homo sapiens 148 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265153 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265153&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020829 377004029 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504706 CCOC(=O)CN1CC(C1)n1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C27H32ClN5O5/c1-5-37-24(34)16-31-14-22(15-31)33-26(35)30-25(29-21-10-11-23(18(4)12-21)38-17(2)3)32(27(33)36)13-19-6-8-20(28)9-7-19/h6-12,17,22H,5,13-16H2,1-4H3,(H,29,30,35) NCQRQTJHNCIKMV-UHFFFAOYSA-N 265154 US9718790, I-1741 P2X purinoceptor 3 Homo sapiens 55.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265154 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265154&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020957 377004030 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504707 CCOC(=O)CCn1c(=O)nc(Nc2ccc(OC(C)C)c(Cl)c2)n(CC2CCCCC2)c1=O InChI=1S/C24H33ClN4O5/c1-4-33-21(30)12-13-28-23(31)27-22(29(24(28)32)15-17-8-6-5-7-9-17)26-18-10-11-20(19(25)14-18)34-16(2)3/h10-11,14,16-17H,4-9,12-13,15H2,1-3H3,(H,26,27,31) NMXZCGVWTFHWPD-UHFFFAOYSA-N 183215 US9150546, I-380::US9688643, I-380::US9718790, I-0380 P2X purinoceptor 3 Homo sapiens 34.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183215 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183215&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821211 313634615 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504708 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(CC(C)C)c(C)c2)n(Cc2ccc(C)cc2)c1=O 265156 US9718790, I-1043 P2X purinoceptor 3 Homo sapiens 10.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265156 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265156&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020827 377004032 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504709 CC(C)Oc1ccc(cc1C)\N=c1/[nH]c(=O)n(C2CN(CC(O)=O)C2)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C25H28ClN5O5/c1-15(2)36-21-9-8-19(10-16(21)3)27-23-28-24(34)31(20-12-29(13-20)14-22(32)33)25(35)30(23)11-17-4-6-18(26)7-5-17/h4-10,15,20H,11-14H2,1-3H3,(H,32,33)(H,27,28,34) KNBIGCCNXXIFIO-UHFFFAOYSA-N 265157 US9718790, I-1742 P2X purinoceptor 3 Homo sapiens 135 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265157 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265157&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020927 377004033 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504710 CC(C)Oc1ccc(Nc2nc(=O)n(CCC(O)=O)c(=O)n2CC2CCCCC2)cc1Cl InChI=1S/C22H29ClN4O5/c1-14(2)32-18-9-8-16(12-17(18)23)24-20-25-21(30)26(11-10-19(28)29)22(31)27(20)13-15-6-4-3-5-7-15/h8-9,12,14-15H,3-7,10-11,13H2,1-2H3,(H,28,29)(H,24,25,30) QKIBFGFDLISDQM-UHFFFAOYSA-N 183216 US9150546, I-382::US9688643, I-382::US9718790, I-0382 P2X purinoceptor 3 Homo sapiens 96.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183216 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183216&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821152 313634616 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504711 CC(C)Cc1ccc(cc1C)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(C)cc1 265159 US9718790, I-1044 P2X purinoceptor 3 Homo sapiens 19.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265159 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265159&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020828 377004035 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504712 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc3[nH]ncc3c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O InChI=1S/C22H19ClN6O4/c1-12(19(30)31)13(2)29-21(32)26-20(25-17-7-8-18-15(9-17)10-24-27-18)28(22(29)33)11-14-3-5-16(23)6-4-14/h3-10,12-13H,11H2,1-2H3,(H,30,31)/b25-17+/t12-,13+/m1/s1 IHCCYTBNHULZAO-DJXJNJKVSA-N 265160 US9718790, I-1743 P2X purinoceptor 3 Homo sapiens 861 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265160 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265160&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020946 377004036 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504713 OCCn1c(=O)nc(Nc2ccc(OC(F)(F)F)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C19H16ClF3N4O4/c20-13-3-1-12(2-4-13)11-27-16(25-17(29)26(9-10-28)18(27)30)24-14-5-7-15(8-6-14)31-19(21,22)23/h1-8,28H,9-11H2,(H,24,25,29) SPZDSFVDXNQRAX-UHFFFAOYSA-N 183217 US9150546, I-383::US9688643, I-383::US9718790, I-0383 P2X purinoceptor 3 Homo sapiens 532 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183217 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183217&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821098 313634617 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504714 CC[C@H](C)COc1ccc(cc1)\N=c1/[nH]c(=O)n(C[C@H](C)C(=O)OC)c(=O)n1Cc1ccc(C)cc1 265162 US9718790, I-1045 P2X purinoceptor 3 Homo sapiens 159 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265162 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265162&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020830 377004038 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504715 CC(C)n1ncc2cc(ccc12)\N=c1/[nH]c(=O)n([C@@H](C)[C@@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 265163 US9718790, I-1744 P2X purinoceptor 3 Homo sapiens 242 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265163 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265163&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278551 377004039 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504716 CCCS(=O)c1ccc(Nc2nc(=O)n(CCO)c(=O)n2Cc2ccc(Cl)cc2)cc1 InChI=1S/C21H23ClN4O4S/c1-2-13-31(30)18-9-7-17(8-10-18)23-19-24-20(28)25(11-12-27)21(29)26(19)14-15-3-5-16(22)6-4-15/h3-10,27H,2,11-14H2,1H3,(H,23,24,28) OTAYHRITIADLTG-UHFFFAOYSA-N 183218 US9150546, I-385::US9688643, I-385::US9718790, I-0385 P2X purinoceptor 3 Homo sapiens 908 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183218 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183218&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821286 313634618 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504717 CCC[C@H](C)Oc1ccc(cc1)\N=c1/[nH]c(=O)n(C[C@H](C)C(=O)OC)c(=O)n1Cc1ccc(C)cc1 265165 US9718790, I-1046 P2X purinoceptor 3 Homo sapiens 28.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265165 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265165&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278301 377004041 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504718 COc1noc2cc(ccc12)\N=c1/[nH]c(=O)n([C@@H](C)[C@@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 265166 US9718790, I-1746 P2X purinoceptor 3 Homo sapiens 129 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265166 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265166&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278597 377004042 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504719 CC(C)Oc1ccc(Nc2nc(=O)n(CCNC(N)=O)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C22H24ClFN6O4/c1-13(2)34-18-8-7-16(11-17(18)24)27-20-28-21(32)29(10-9-26-19(25)31)22(33)30(20)12-14-3-5-15(23)6-4-14/h3-8,11,13H,9-10,12H2,1-2H3,(H3,25,26,31)(H,27,28,32) WGRJWKPPVJDRMX-UHFFFAOYSA-N 183219 US9150546, I-386::US9688643, I-386::US9718790, I-0386 P2X purinoceptor 3 Homo sapiens 41.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183219 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183219&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 77888201 313634619 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504720 CCC[C@@H](C)Oc1ccc(cc1)\N=c1/[nH]c(=O)n(C[C@H](C)C(=O)OC)c(=O)n1Cc1ccc(C)cc1 265168 US9718790, I-1047 P2X purinoceptor 3 Homo sapiens 154 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265168 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265168&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945404 377004044 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504721 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc3oc4CCCCCc4c3c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 265169 US9718790, I-1747 P2X purinoceptor 3 Homo sapiens 201 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265169 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265169&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278202 377004045 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504722 CNC(=O)NCCn1c(=O)nc(Nc2ccc(OC(C)C)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H26ClFN6O4/c1-14(2)35-19-9-8-17(12-18(19)25)28-20-29-22(33)30(11-10-27-21(32)26-3)23(34)31(20)13-15-4-6-16(24)7-5-15/h4-9,12,14H,10-11,13H2,1-3H3,(H2,26,27,32)(H,28,29,33) GBKQOARKSUDDPS-UHFFFAOYSA-N 183220 US9150546, I-387::US9688643, I-387::US9718790, I-0387 P2X purinoceptor 3 Homo sapiens 37.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183220 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183220&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 77387734 313634620 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504723 CCC(CC)Oc1ccc(cc1)\N=c1/[nH]c(=O)n(C[C@H](C)C(=O)OC)c(=O)n1Cc1ccc(C)cc1 265171 US9718790, I-1048 P2X purinoceptor 3 Homo sapiens 38.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265171 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265171&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020096 377004047 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504724 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc3oc4CCCCc4c3c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 265172 US9718790, I-1748 P2X purinoceptor 3 Homo sapiens 236 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265172 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265172&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945530 377004048 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504725 CC(C)Oc1ccc(Nc2nc(=O)n(CCNC(=O)N(C)C)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C24H28ClFN6O4/c1-15(2)36-20-10-9-18(13-19(20)26)28-21-29-23(34)31(12-11-27-22(33)30(3)4)24(35)32(21)14-16-5-7-17(25)8-6-16/h5-10,13,15H,11-12,14H2,1-4H3,(H,27,33)(H,28,29,34) LQVUMSPACOUIKQ-UHFFFAOYSA-N 183221 US9150546, I-388::US9688643, I-388::US9718790, I-0388 P2X purinoceptor 3 Homo sapiens 36.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183221 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183221&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 77888222 313634621 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504726 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(OCCC(C)C)cc2)n(Cc2ccc(C)cc2)c1=O 265174 US9718790, I-1049 P2X purinoceptor 3 Homo sapiens 177 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265174 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265174&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278302 377004050 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504727 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n(CCC(O)=O)c(=O)n1CC1CCC(C)CC1 InChI=1S/C23H31FN4O5/c1-14(2)33-19-9-8-17(12-18(19)24)25-21-26-22(31)27(11-10-20(29)30)23(32)28(21)13-16-6-4-15(3)5-7-16/h8-9,12,14-16H,4-7,10-11,13H2,1-3H3,(H,29,30)(H,25,26,31) HCNGCMJCDDSOOO-UHFFFAOYSA-N 265175 US9718790, I-1750 P2X purinoceptor 3 Homo sapiens 21.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265175 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265175&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020980 377004051 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504728 CCNC(=O)NCCn1c(=O)nc(Nc2ccc(OC(C)C)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H28ClFN6O4/c1-4-27-22(33)28-11-12-31-23(34)30-21(29-18-9-10-20(19(26)13-18)36-15(2)3)32(24(31)35)14-16-5-7-17(25)8-6-16/h5-10,13,15H,4,11-12,14H2,1-3H3,(H2,27,28,33)(H,29,30,34) OPMCGYFGAQSGMM-UHFFFAOYSA-N 183222 US9150546, I-389::US9688643, I-389::US9718790, I-0389 P2X purinoceptor 3 Homo sapiens 64.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183222 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183222&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 77387733 313634622 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504729 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(OCC(C)(C)C)cc2)n(Cc2ccc(C)cc2)c1=O 265177 US9718790, I-1050 P2X purinoceptor 3 Homo sapiens 389 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265177 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265177&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278484 377004053 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504730 CCc1nc2ccc(cc2s1)\N=c1/[nH]c(=O)n(CC(=O)OC)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C22H20ClN5O4S/c1-3-18-25-16-9-8-15(10-17(16)33-18)24-20-26-21(30)28(12-19(29)32-2)22(31)27(20)11-13-4-6-14(23)7-5-13/h4-10H,3,11-12H2,1-2H3,(H,24,26,30) SFSDJLFKYOHWQR-UHFFFAOYSA-N 265178 US9718790, I-1752 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265178 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265178&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020473 377004054 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 504731 CC(C)Oc1ccc(Nc2nc(=O)n(CCNC(=O)NCCO)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C24H28ClFN6O5/c1-15(2)37-20-8-7-18(13-19(20)26)29-21-30-23(35)31(11-9-27-22(34)28-10-12-33)24(36)32(21)14-16-3-5-17(25)6-4-16/h3-8,13,15,33H,9-12,14H2,1-2H3,(H2,27,28,34)(H,29,30,35) UYTSYZVVZRWWPG-UHFFFAOYSA-N 183223 US9150546, I-390::US9688643, I-390::US9718790, I-0390 P2X purinoceptor 3 Homo sapiens 67.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183223 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183223&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 77888253 313634623 C04080 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505159 CCOC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(F)c3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C27H24ClFN4O5/c1-2-37-24(34)14-15-32-26(35)31-25(33(27(32)36)17-18-6-8-19(28)9-7-18)30-21-10-12-22(13-11-21)38-23-5-3-4-20(29)16-23/h3-13,16H,2,14-15,17H2,1H3,(H,30,31,35) RPYHPHZLWKUHKI-UHFFFAOYSA-N 265600 US9718790, I-1937 P2X purinoceptor 3 Homo sapiens 22.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265600 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265600&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019844 377004473 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505160 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc3oc(C)cc3c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 183366 US9150546, I-540::US9688643, I-540::US9718790, I-0549 P2X purinoceptor 3 Homo sapiens 27.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183366 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183366&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578454 313634766 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505161 CCCc1ccc(cc1C)\N=c1/[nH]c(=O)n(C[C@H](C)C(=O)OC)c(=O)n1Cc1ccc(C)cc1 265602 US9718790, I-1210 P2X purinoceptor 3 Homo sapiens 37.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265602 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265602&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021035 377004475 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505162 CCOC(=O)c1cc2cc(ccc2o1)\N=c1/[nH]c(=O)n(C[C@H](C)C(=O)OC)c(=O)n1Cc1ccc(Cl)cc1 265603 US9718790, I-1938 P2X purinoceptor 3 Homo sapiens 312 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265603 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265603&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945307 377004476 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505163 CC(C)Oc1ccc(cc1)\N=c1/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C24H27ClN4O5/c1-15(2)34-19-11-9-18(10-12-19)26-21-27-22(32)29(14-24(3,4)20(30)31)23(33)28(21)13-16-5-7-17(25)8-6-16/h5-12,15H,13-14H2,1-4H3,(H,30,31)(H,26,27,32) JCPCQJZKKYRYKO-UHFFFAOYSA-N 183367 US9150546, I-541::US9688643, I-541::US9718790, I-0550 P2X purinoceptor 3 Homo sapiens 58.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183367 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183367&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578444 313634767 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505164 CCCc1ccc(cc1C)\N=c1/[nH]c(=O)n(C[C@H](C)C(=O)OC)c(=O)n1Cc1ccc(Cl)cc1 265605 US9718790, I-1211 P2X purinoceptor 3 Homo sapiens 30.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265605 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265605&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019892 377004478 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505165 COC(=O)Cn1c(=O)[nH]\c(=N/c2ccc(OC3CCC3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H23ClN4O5/c1-32-20(29)14-28-22(30)26-21(27(23(28)31)13-15-5-7-16(24)8-6-15)25-17-9-11-19(12-10-17)33-18-3-2-4-18/h5-12,18H,2-4,13-14H2,1H3,(H,25,26,30) WDKBZAAINXYIPT-UHFFFAOYSA-N 265606 US9718790, I-1939 P2X purinoceptor 3 Homo sapiens 30.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265606 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265606&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020028 377004479 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505166 CCOc1ccc(cc1)\N=c1/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C23H25ClN4O5/c1-4-33-18-11-9-17(10-12-18)25-20-26-21(31)28(14-23(2,3)19(29)30)22(32)27(20)13-15-5-7-16(24)8-6-15/h5-12H,4,13-14H2,1-3H3,(H,29,30)(H,25,26,31) XUZSADSANSSCJR-UHFFFAOYSA-N 183368 US9150546, I-542::US9688643, I-542::US9718790, I-0551 P2X purinoceptor 3 Homo sapiens 96.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183368 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183368&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578394 313634768 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505167 CCCc1ccc(cc1C)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(C)cc1 265608 US9718790, I-1212 P2X purinoceptor 3 Homo sapiens 90.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265608 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265608&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019917 377004481 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505168 NC(=O)Cn1c(=O)[nH]\c(=N/c2ccc(OCC3CC3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C22H22ClN5O4/c23-16-5-3-14(4-6-16)11-27-20(26-21(30)28(22(27)31)12-19(24)29)25-17-7-9-18(10-8-17)32-13-15-1-2-15/h3-10,15H,1-2,11-13H2,(H2,24,29)(H,25,26,30) LXLIIDDXLGLAKW-UHFFFAOYSA-N 265609 US9718790, I-1940 P2X purinoceptor 3 Homo sapiens 55.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265609 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265609&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019845 377004482 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505169 CC(C)(Cn1c(=O)[nH]\c(=N/c2ccc(OC(F)F)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O InChI=1S/C22H21ClF2N4O5/c1-22(2,17(30)31)12-29-20(32)27-19(26-15-7-9-16(10-8-15)34-18(24)25)28(21(29)33)11-13-3-5-14(23)6-4-13/h3-10,18H,11-12H2,1-2H3,(H,30,31)(H,26,27,32) GYEVZEZSHHFIPQ-UHFFFAOYSA-N 183369 US9150546, I-543::US9688643, I-543::US9718790, I-0552 P2X purinoceptor 3 Homo sapiens 172 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183369 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183369&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578802 313634769 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505170 CCCc1ccc(cc1C)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 265611 US9718790, I-1213 P2X purinoceptor 3 Homo sapiens 104 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265611 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265611&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019914 377004484 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505171 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cc(on3)C(=O)OC)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H20ClN5O6/c1-3-28-22(31)26-21(29(23(28)32)13-14-4-6-15(24)7-5-14)25-16-8-10-17(11-9-16)34-19-12-18(35-27-19)20(30)33-2/h4-12H,3,13H2,1-2H3,(H,25,26,31) ONURFTCUNGTRMI-UHFFFAOYSA-N 265612 US9718790, I-1941 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265612 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265612&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278309 377004485 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505172 CSc1ccc(cc1)\N=c1/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C22H23ClN4O4S/c1-22(2,18(28)29)13-27-20(30)25-19(24-16-8-10-17(32-3)11-9-16)26(21(27)31)12-14-4-6-15(23)7-5-14/h4-11H,12-13H2,1-3H3,(H,28,29)(H,24,25,30) CZLXUMOXYGNOSM-UHFFFAOYSA-N 183370 US9150546, I-544::US9688643, I-544::US9718790, I-0553 P2X purinoceptor 3 Homo sapiens 601 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183370 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183370&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578952 313634770 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505173 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(CCC3CC3)cc2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 265614 US9718790, I-1214 P2X purinoceptor 3 Homo sapiens 70.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265614 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265614&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019919 377004487 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505174 CNC(=O)Cn1c(=O)[nH]\c(=N/c2ccc(OCC3CC3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H24ClN5O4/c1-25-20(30)13-29-22(31)27-21(28(23(29)32)12-15-4-6-17(24)7-5-15)26-18-8-10-19(11-9-18)33-14-16-2-3-16/h4-11,16H,2-3,12-14H2,1H3,(H,25,30)(H,26,27,31) CUFQYRDNURPCNR-UHFFFAOYSA-N 265615 US9718790, I-1942 P2X purinoceptor 3 Homo sapiens 49.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265615 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265615&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020339 377004488 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505175 CC(C)Oc1ccc(Nc2nc(=O)n(CCOC3CCCCO3)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C26H30ClFN4O5/c1-17(2)37-22-11-10-20(15-21(22)28)29-24-30-25(33)31(12-14-36-23-5-3-4-13-35-23)26(34)32(24)16-18-6-8-19(27)9-7-18/h6-11,15,17,23H,3-5,12-14,16H2,1-2H3,(H,29,30,33) RKURIGKRJVTWEA-UHFFFAOYSA-N 183371 US9150546, I-545::US9688643, I-545::US9718790, I-0554 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183371 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183371&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76820961 313634771 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505176 CCCc1ccc(cc1C)\N=c1/[nH]c(=O)n(CCC(=O)OCC)c(=O)n1Cc1ccc(C)cc1 InChI=1S/C26H32N4O4/c1-5-7-21-12-13-22(16-19(21)4)27-24-28-25(32)29(15-14-23(31)34-6-2)26(33)30(24)17-20-10-8-18(3)9-11-20/h8-13,16H,5-7,14-15,17H2,1-4H3,(H,27,28,32) RCFVULAFIXNNQT-UHFFFAOYSA-N 265617 US9718790, I-1215 P2X purinoceptor 3 Homo sapiens 27.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265617 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265617&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019920 377004490 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505178 CC(C)Oc1ccc(cc1F)\N=c1/n(C)c(=O)n(CCOC2CCCCO2)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C27H32ClFN4O5/c1-18(2)38-23-12-11-21(16-22(23)29)30-25-31(3)26(34)32(13-15-37-24-6-4-5-14-36-24)27(35)33(25)17-19-7-9-20(28)10-8-19/h7-12,16,18,24H,4-6,13-15,17H2,1-3H3/b30-25+ NYQXKNHJLZHVCJ-QCWLDUFUSA-N 183372 US9150546, I-546::US9688643, I-546::US9718790, I-0555 P2X purinoceptor 3 Homo sapiens 459 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183372 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183372&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578748 313634772 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505179 CCOC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(CC(C)C)c(C)c2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C27H34N4O4/c1-6-35-24(32)13-14-30-26(33)29-25(28-23-12-11-22(15-18(2)3)20(5)16-23)31(27(30)34)17-21-9-7-19(4)8-10-21/h7-12,16,18H,6,13-15,17H2,1-5H3,(H,28,29,33) XLXHFXWKUKOWTP-UHFFFAOYSA-N 265619 US9718790, I-1216 P2X purinoceptor 3 Homo sapiens 13.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265619 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265619&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278231 377004492 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505180 Cc1ccc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(CC(N)=O)c(=O)n2Cc2ccc(Cl)cc2)cn1 InChI=1S/C24H21ClN6O4/c1-15-2-9-20(12-27-15)35-19-10-7-18(8-11-19)28-22-29-23(33)31(14-21(26)32)24(34)30(22)13-16-3-5-17(25)6-4-16/h2-12H,13-14H2,1H3,(H2,26,32)(H,28,29,33) WAUDWQRIPUAQAM-UHFFFAOYSA-N 265620 US9718790, I-1944 P2X purinoceptor 3 Homo sapiens 11.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265620 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265620&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020304 377004493 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505181 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(Cl)c2)n(CC2CCCCC2)c1=O InChI=1S/C25H35ClN4O5/c1-16(2)35-20-12-11-18(13-19(20)26)27-22-28-23(32)30(15-25(3,4)21(31)34-5)24(33)29(22)14-17-9-7-6-8-10-17/h11-13,16-17H,6-10,14-15H2,1-5H3,(H,27,28,32) DEKOKCCTTJDCJS-UHFFFAOYSA-N 183373 US9150546, I-547::US9688643, I-547::US9718790, I-0556 P2X purinoceptor 3 Homo sapiens 11.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183373 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183373&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578842 313634773 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505182 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(OC3CCC3)cc2)n(Cc2ccc(C)cc2)c1=O 265622 US9718790, I-1217 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265622 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265622&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945136 377004495 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505183 CNC(=O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(C)nc3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H23ClN6O4/c1-16-3-10-21(13-28-16)36-20-11-8-19(9-12-20)29-23-30-24(34)32(15-22(33)27-2)25(35)31(23)14-17-4-6-18(26)7-5-17/h3-13H,14-15H2,1-2H3,(H,27,33)(H,29,30,34) FCNDKZRBJCHLPE-UHFFFAOYSA-N 265623 US9718790, I-1945 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265623 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265623&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020180 377004496 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505184 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(Cl)c2)n(CC2CCCCC2)c1=O 183374 US9150546, I-548::US9688643, I-548::US9718790, I-0557 P2X purinoceptor 3 Homo sapiens 12.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183374 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183374&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578956 313634774 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505185 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(OC3COC3)cc2)n(Cc2ccc(C)cc2)c1=O 265625 US9718790, I-1218 P2X purinoceptor 3 Homo sapiens 61.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265625 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265625&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020859 377004498 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505186 NC(=O)Cn1c(=O)[nH]\c(=N/c2ccc(OC3CCC3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C22H22ClN5O4/c23-15-6-4-14(5-7-15)12-27-20(26-21(30)28(22(27)31)13-19(24)29)25-16-8-10-18(11-9-16)32-17-2-1-3-17/h4-11,17H,1-3,12-13H2,(H2,24,29)(H,25,26,30) WKJDWDFNRCOANH-UHFFFAOYSA-N 265626 US9718790, I-1946 P2X purinoceptor 3 Homo sapiens 25.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265626 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265626&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945600 377004499 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505187 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(Cl)c2)n(CC2CCCCCC2)c1=O InChI=1S/C26H37ClN4O5/c1-17(2)36-21-13-12-19(14-20(21)27)28-23-29-24(33)31(16-26(3,4)22(32)35-5)25(34)30(23)15-18-10-8-6-7-9-11-18/h12-14,17-18H,6-11,15-16H2,1-5H3,(H,28,29,33) NEKLZKIZXQWIFI-UHFFFAOYSA-N 183375 US9150546, I-549::US9688643, I-549::US9718790, I-0558 P2X purinoceptor 3 Homo sapiens 19.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183375 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183375&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578662 313634775 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505188 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(OC3CCCCC3)cc2)n(Cc2ccc(C)cc2)c1=O 265628 US9718790, I-1219 P2X purinoceptor 3 Homo sapiens 29.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265628 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265628&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278563 377004501 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505190 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(Cl)c2)n(CC2CCCC2)c1=O InChI=1S/C24H33ClN4O5/c1-15(2)34-19-11-10-17(12-18(19)25)26-21-27-22(31)29(14-24(3,4)20(30)33-5)23(32)28(21)13-16-8-6-7-9-16/h10-12,15-16H,6-9,13-14H2,1-5H3,(H,26,27,31) HESZPANWMDSMDF-UHFFFAOYSA-N 183376 US9150546, I-550::US9688643, I-550::US9718790, I-0559 P2X purinoceptor 3 Homo sapiens 33.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183376 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183376&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578533 313634776 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505191 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(OC3CCC3)cc2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 265630 US9718790, I-1220::US9718790, I-1225 P2X purinoceptor 3 Homo sapiens 13.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265630 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265630&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020851 377004503 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505192 CNC(=O)Cn1c(=O)[nH]\c(=N/c2ccc(OC3CCC3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H24ClN5O4/c1-25-20(30)14-29-22(31)27-21(28(23(29)32)13-15-5-7-16(24)8-6-15)26-17-9-11-19(12-10-17)33-18-3-2-4-18/h5-12,18H,2-4,13-14H2,1H3,(H,25,30)(H,26,27,31) CKEYJYZDTIXANS-UHFFFAOYSA-N 265631 US9718790, I-1948 P2X purinoceptor 3 Homo sapiens 22.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265631 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265631&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020633 377004504 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505193 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n1CC1CCCCC1 InChI=1S/C24H33ClN4O5/c1-15(2)34-19-11-10-17(12-18(19)25)26-21-27-22(32)29(14-24(3,4)20(30)31)23(33)28(21)13-16-8-6-5-7-9-16/h10-12,15-16H,5-9,13-14H2,1-4H3,(H,30,31)(H,26,27,32) NMNCTROXPGYIOQ-UHFFFAOYSA-N 183377 US9150546, I-551::US9688643, I-551::US9718790, I-0560 P2X purinoceptor 3 Homo sapiens 34.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183377 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183377&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578406 313634777 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505194 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(OC3COC3)cc2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 265633 US9718790, I-1221 P2X purinoceptor 3 Homo sapiens 117 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265633 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265633&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278564 377004506 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505195 Cc1[nH]c2ccc(cc2c1C)\N=c1/[nH]c(=O)n(CCCO)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C23H24ClN5O3/c1-14-15(2)25-20-9-8-18(12-19(14)20)26-21-27-22(31)28(10-3-11-30)23(32)29(21)13-16-4-6-17(24)7-5-16/h4-9,12,25,30H,3,10-11,13H2,1-2H3,(H,26,27,31) WZTNDTPFFNYSDJ-UHFFFAOYSA-N 265634 US9718790, I-1949 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265634 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265634&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020635 377004507 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505196 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1CC1CCCCC1 183378 US9150546, I-552::US9688643, I-552::US9718790, I-0561 P2X purinoceptor 3 Homo sapiens 23.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183378 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183378&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578395 313634778 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505197 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(OC3CCCCC3)cc2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 265636 US9718790, I-1222 P2X purinoceptor 3 Homo sapiens 17.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265636 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265636&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278232 377004509 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505198 Cc1[nH]c2ccc(cc2c1C)\N=c1/[nH]c(=O)n(CCC(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C23H22ClN5O4/c1-13-14(2)25-19-8-7-17(11-18(13)19)26-21-27-22(32)28(10-9-20(30)31)23(33)29(21)12-15-3-5-16(24)6-4-15/h3-8,11,25H,9-10,12H2,1-2H3,(H,30,31)(H,26,27,32) QIUBLAPNJJNZEV-UHFFFAOYSA-N 265637 US9718790, I-1950 P2X purinoceptor 3 Homo sapiens 29.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265637 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265637&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020570 377004510 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505199 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n1CC1CCCCCC1 InChI=1S/C25H35ClN4O5/c1-16(2)35-20-12-11-18(13-19(20)26)27-22-28-23(33)30(15-25(3,4)21(31)32)24(34)29(22)14-17-9-7-5-6-8-10-17/h11-13,16-17H,5-10,14-15H2,1-4H3,(H,31,32)(H,27,28,33) ZVPWBFOPYYQMCZ-UHFFFAOYSA-N 183379 US9150546, I-553::US9688643, I-553::US9718790, I-0562 P2X purinoceptor 3 Homo sapiens 34.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183379 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183379&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578707 313634779 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505200 CCCc1ccc(cc1C)\N=c1/[nH]c(=O)n(CCC(O)=O)c(=O)n1Cc1ccc(C)cc1 InChI=1S/C24H28N4O4/c1-4-5-19-10-11-20(14-17(19)3)25-22-26-23(31)27(13-12-21(29)30)24(32)28(22)15-18-8-6-16(2)7-9-18/h6-11,14H,4-5,12-13,15H2,1-3H3,(H,29,30)(H,25,26,31) HYBMMQREVMKJOE-UHFFFAOYSA-N 265639 US9718790, I-1223 P2X purinoceptor 3 Homo sapiens 297 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265639 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265639&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278565 377004512 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505202 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n1CC1CCCC1 InChI=1S/C23H31ClN4O5/c1-14(2)33-18-10-9-16(11-17(18)24)25-20-26-21(31)28(13-23(3,4)19(29)30)22(32)27(20)12-15-7-5-6-8-15/h9-11,14-15H,5-8,12-13H2,1-4H3,(H,29,30)(H,25,26,31) KHYUIQKXCLVOAV-UHFFFAOYSA-N 183380 US9150546, I-554::US9688643, I-554::US9718790, I-0563 P2X purinoceptor 3 Homo sapiens 139 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183380 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183380&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578656 313634780 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505203 CC(C)Cc1ccc(cc1C)\N=c1/[nH]c(=O)n(CCC(O)=O)c(=O)n1Cc1ccc(C)cc1 InChI=1S/C25H30N4O4/c1-16(2)13-20-9-10-21(14-18(20)4)26-23-27-24(32)28(12-11-22(30)31)25(33)29(23)15-19-7-5-17(3)6-8-19/h5-10,14,16H,11-13,15H2,1-4H3,(H,30,31)(H,26,27,32) SZVHCIGNFSYFTR-UHFFFAOYSA-N 265641 US9718790, I-1224 P2X purinoceptor 3 Homo sapiens 54.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265641 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265641&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945067 377004514 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505204 OC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(F)c3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H20ClFN4O5/c26-17-6-4-16(5-7-17)15-31-23(29-24(34)30(25(31)35)13-12-22(32)33)28-19-8-10-20(11-9-19)36-21-3-1-2-18(27)14-21/h1-11,14H,12-13,15H2,(H,32,33)(H,28,29,34) AFFBQCPDUAGNNM-UHFFFAOYSA-N 265642 US9718790, I-1952 P2X purinoceptor 3 Homo sapiens 781 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265642 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265642&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945358 377004515 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505205 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(C)c2)n(CC2CCCCC2)c1=O 183381 US9150546, I-555::US9688643, I-555::US9718790, I-0564 P2X purinoceptor 3 Homo sapiens 13.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183381 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183381&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578401 313634781 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505206 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(OC3CCC3)cc2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 265630 US9718790, I-1220::US9718790, I-1225 P2X purinoceptor 3 Homo sapiens 82.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265630 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265630&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020851 377004503 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505207 C[C@@H](Oc1ccc(cc1)\N=c1/[nH]c(=O)n(CCCO)c(=O)n1Cc1ccc(C)cc1)C(F)(F)F 265645 US9718790, I-1953 P2X purinoceptor 3 Homo sapiens 16.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265645 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265645&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020530 377004517 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505208 COC(=O)C[C@@H](C)n1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(Cl)c2)n(Cc2ccc(Cl)cc2)c1=O 183382 US9150546, I-556::US9688643, I-556::US9718790, I-0565 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183382 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183382&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578716 313634782 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505209 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(OC3CCCC3)nc2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 265647 US9718790, I-1226 P2X purinoceptor 3 Homo sapiens 122 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265647 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265647&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278566 377004519 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505210 Cc1cc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(CC(CO)CO)c(=O)n2Cc2ccc(Cl)cc2)ccn1 InChI=1S/C26H26ClN5O5/c1-17-12-23(10-11-28-17)37-22-8-6-21(7-9-22)29-24-30-25(35)32(14-19(15-33)16-34)26(36)31(24)13-18-2-4-20(27)5-3-18/h2-12,19,33-34H,13-16H2,1H3,(H,29,30,35) OQXCLVVHMLGTQJ-UHFFFAOYSA-N 265648 US9718790, I-1954 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265648 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265648&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278591 377004520 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505211 COC(=O)C[C@@H](C)n1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O 183383 US9150546, I-557::US9688643, I-557::US9718790, I-0566 P2X purinoceptor 3 Homo sapiens 19.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183383 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183383&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578452 313634783 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505212 Cc1ccc(Cn2c(=O)n(CCC(O)=O)c(=O)[nH]\c2=N/c2ccc(Oc3cccnc3)cc2)cc1 InChI=1S/C25H23N5O5/c1-17-4-6-18(7-5-17)16-30-23(28-24(33)29(25(30)34)14-12-22(31)32)27-19-8-10-20(11-9-19)35-21-3-2-13-26-15-21/h2-11,13,15H,12,14,16H2,1H3,(H,31,32)(H,27,28,33) SPVLEHMZZWRCJA-UHFFFAOYSA-N 265650 US9718790, I-1227 P2X purinoceptor 3 Homo sapiens 30.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265650 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265650&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019605 377004522 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505213 Cc1cc(Oc2ccc(cc2)\N=c2/[nH]c(=O)[nH]c(=O)n2Cc2ccc(Cl)cc2)ccn1 InChI=1S/C22H18ClN5O3/c1-14-12-19(10-11-24-14)31-18-8-6-17(7-9-18)25-20-26-21(29)27-22(30)28(20)13-15-2-4-16(23)5-3-15/h2-12H,13H2,1H3,(H2,25,26,27,29,30) QXWLSMZJNDINLZ-UHFFFAOYSA-N 265651 US9718790, I-1955 P2X purinoceptor 3 Homo sapiens 97.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265651 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265651&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945669 377004523 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505214 COC(=O)[C@H](C)Cn1c(=O)[nH]\c(=N/c2ccc3oc(C)cc3c2)n(Cc2ccc(Cl)cc2)c1=O 183384 US9150546, I-558::US9688643, I-558::US9718790, I-0567 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183384 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183384&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578519 313634784 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505215 Cc1ccc(Cn2c(=O)n(CCC(O)=O)c(=O)[nH]\c2=N/c2ccc(Oc3ccncc3)cc2)cc1 InChI=1S/C25H23N5O5/c1-17-2-4-18(5-3-17)16-30-23(28-24(33)29(25(30)34)15-12-22(31)32)27-19-6-8-20(9-7-19)35-21-10-13-26-14-11-21/h2-11,13-14H,12,15-16H2,1H3,(H,31,32)(H,27,28,33) DYQDUADZZQTWSS-UHFFFAOYSA-N 265653 US9718790, I-1228 P2X purinoceptor 3 Homo sapiens 9.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265653 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265653&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945192 377004525 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505216 C[C@@H](Oc1ccc(cc1)\N=c1/[nH]c(=O)n(CCC(N)=O)c(=O)n1Cc1ccc(Cl)cc1)C(F)(F)F 265654 US9718790, I-1956 P2X purinoceptor 3 Homo sapiens 34.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265654 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265654&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278384 377004526 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505217 CC(C)Oc1ccc(cc1C)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1CC1CCCCC1 183385 US9150546, I-559::US9688643, I-559::US9718790, I-0568 P2X purinoceptor 3 Homo sapiens 97.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183385 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183385&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578595 313634785 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505218 CCOC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cccnc3)cc2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C27H27N5O5/c1-3-36-24(33)14-16-31-26(34)30-25(32(27(31)35)18-20-8-6-19(2)7-9-20)29-21-10-12-22(13-11-21)37-23-5-4-15-28-17-23/h4-13,15,17H,3,14,16,18H2,1-2H3,(H,29,30,34) ZWEXGUATAYORLT-UHFFFAOYSA-N 265656 US9718790, I-1229 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265656 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265656&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945476 377004528 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505219 CNC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(O[C@H](C)C(F)(F)F)cc2)n(Cc2ccc(Cl)cc2)c1=O 265657 US9718790, I-1957 P2X purinoceptor 3 Homo sapiens 22.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265657 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265657&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278592 377004529 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505220 COC(=O)C[C@@H](C)n1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O 183386 US9150546, I-560::US9688643, I-560::US9718790, I-0569 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183386 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183386&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578772 313634786 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505221 CCOC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccncc3)cc2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C27H27N5O5/c1-3-36-24(33)14-17-31-26(34)30-25(32(27(31)35)18-20-6-4-19(2)5-7-20)29-21-8-10-22(11-9-21)37-23-12-15-28-16-13-23/h4-13,15-16H,3,14,17-18H2,1-2H3,(H,29,30,34) PVRNNWPKCQLQIV-UHFFFAOYSA-N 265659 US9718790, I-1230 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265659 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265659&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945079 377004531 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505222 C[C@@H](Oc1ccc(cc1)\N=c1/[nH]c(=O)n(CCC(=O)NCC(F)(F)F)c(=O)n1Cc1ccc(Cl)cc1)C(F)(F)F 265660 US9718790, I-1958 P2X purinoceptor 3 Homo sapiens 16.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265660 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265660&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278215 377004532 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505223 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n([C@H](C)CC(O)=O)c(=O)n1Cc1ccc(Cl)cc1 183387 US9150546, I-561::US9688643, I-561::US9718790, I-0570 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183387 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183387&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578547 313634787 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505224 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cccnc3C)cc2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 265662 US9718790, I-1231 P2X purinoceptor 3 Homo sapiens 36.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265662 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265662&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945078 377004534 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505225 C[C@@H](Oc1ccc(cc1)\N=c1/[nH]c(=O)n(CC(N)=O)c(=O)n1Cc1ccc(Cl)cc1)C(F)(F)F 265663 US9718790, I-1959 P2X purinoceptor 3 Homo sapiens 65.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265663 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265663&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021181 377004535 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505226 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n([C@H](C)CC(O)=O)c(=O)n1Cc1ccc(Cl)cc1 183388 US9150546, I-562::US9688643, I-562::US9718790, I-0571 P2X purinoceptor 3 Homo sapiens 27.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183388 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183388&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578745 313634788 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 505227 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(C)nc3)cc2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 265665 US10065941, Compound R-210::US9718790, I-1232 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265665 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265665&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278497 377004537 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506396 Cc1ccc(Cn2c(=O)n(CCC(N)=O)c(=O)[nH]\c2=N/c2ccc(Oc3ncccn3)cc2)cc1 InChI=1S/C24H23N7O4/c1-16-3-5-17(6-4-16)15-31-21(29-23(33)30(24(31)34)14-11-20(25)32)28-18-7-9-19(10-8-18)35-22-26-12-2-13-27-22/h2-10,12-13H,11,14-15H2,1H3,(H2,25,32)(H,28,29,33) XOSOXDBMQITCQO-UHFFFAOYSA-N 266829 US9718790, I-2566 P2X purinoceptor 3 Homo sapiens 17.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266829 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266829&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278376 377005700 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506397 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ncc(s3)C(O)=O)cc2)n(Cc2ccc(F)cc2)c1=O InChI=1S/C22H18FN5O5S/c1-2-27-20(31)26-19(28(22(27)32)12-13-3-5-14(23)6-4-13)25-15-7-9-16(10-8-15)33-21-24-11-17(34-21)18(29)30/h3-11H,2,12H2,1H3,(H,29,30)(H,25,26,31) XXYQLQJKSIWCRR-UHFFFAOYSA-N 266830 US9718790, I-2567 P2X purinoceptor 3 Homo sapiens 38.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266830 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266830&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945703 377005701 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506398 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3nc(cs3)C(O)=O)cc2)n(Cc2ccc(F)cc2)c1=O InChI=1S/C22H18FN5O5S/c1-2-27-20(31)26-19(28(22(27)32)11-13-3-5-14(23)6-4-13)24-15-7-9-16(10-8-15)33-21-25-17(12-34-21)18(29)30/h3-10,12H,2,11H2,1H3,(H,29,30)(H,24,26,31) POOLOPIZQWRSLL-UHFFFAOYSA-N 266831 US9718790, I-2568 P2X purinoceptor 3 Homo sapiens 87.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266831 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266831&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020600 377005702 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506399 CCn1c(=O)[nH]\c(=N/c2ccc(Nc3ccncc3)cc2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C24H24N6O2/c1-3-29-23(31)28-22(30(24(29)32)16-18-6-4-17(2)5-7-18)27-20-10-8-19(9-11-20)26-21-12-14-25-15-13-21/h4-15H,3,16H2,1-2H3,(H,25,26)(H,27,28,31) CUPRVIRGOORXBD-UHFFFAOYSA-N 266832 US9718790, I-2569 P2X purinoceptor 3 Homo sapiens 162 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266832 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266832&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945475 377005703 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506400 CCOC(=O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3nc(C)ns3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H21ClN6O5S/c1-3-34-19(31)13-30-21(32)27-20(29(23(30)33)12-15-4-6-16(24)7-5-15)26-17-8-10-18(11-9-17)35-22-25-14(2)28-36-22/h4-11H,3,12-13H2,1-2H3,(H,26,27,32) KZBKATADJVPPBU-UHFFFAOYSA-N 266833 US9718790, I-2570 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266833 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266833&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020622 377005704 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506401 Cc1nsc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(CC(C)(CO)CO)c(=O)n2Cc2ccc(F)cc2)n1 InChI=1S/C24H25FN6O5S/c1-15-26-22(37-29-15)36-19-9-7-18(8-10-19)27-20-28-21(34)31(12-24(2,13-32)14-33)23(35)30(20)11-16-3-5-17(25)6-4-16/h3-10,32-33H,11-14H2,1-2H3,(H,27,28,34) PELDPBWZGKFQAE-UHFFFAOYSA-N 266834 US9718790, I-2571 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266834 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266834&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020624 377005705 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506402 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccncc3)cc2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C24H23N5O3/c1-3-28-23(30)27-22(29(24(28)31)16-18-6-4-17(2)5-7-18)26-19-8-10-20(11-9-19)32-21-12-14-25-15-13-21/h4-15H,3,16H2,1-2H3,(H,26,27,30) XGCXQPJYCXMATN-UHFFFAOYSA-N 266835 US9718790, I-2573 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266835 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266835&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019806 377005706 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506403 CC(CO)(CO)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccon3)c(F)c2)n(Cc2ccc(F)cc2)c1=O InChI=1S/C24H23F2N5O6/c1-24(13-32,14-33)12-31-22(34)28-21(30(23(31)35)11-15-2-4-16(25)5-3-15)27-17-6-7-19(18(26)10-17)37-20-8-9-36-29-20/h2-10,32-33H,11-14H2,1H3,(H,27,28,34) IIYRKIVCXDKHGE-UHFFFAOYSA-N 266836 US9718790, I-2574 P2X purinoceptor 3 Homo sapiens 11.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266836 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266836&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019807 377005707 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506404 Cc1nsc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(CCO)c(=O)n2Cc2ccc(Cl)cc2)n1 InChI=1S/C21H19ClN6O4S/c1-13-23-20(33-26-13)32-17-8-6-16(7-9-17)24-18-25-19(30)27(10-11-29)21(31)28(18)12-14-2-4-15(22)5-3-14/h2-9,29H,10-12H2,1H3,(H,24,25,30) KYWJWVVMRDVXPM-UHFFFAOYSA-N 266837 US9718790, I-2575 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266837 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266837&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019849 377005708 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506405 Cc1nsc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(CC(C)(CO)CO)c(=O)n2Cc2ccc(Cl)cc2)n1 InChI=1S/C24H25ClN6O5S/c1-15-26-22(37-29-15)36-19-9-7-18(8-10-19)27-20-28-21(34)31(12-24(2,13-32)14-33)23(35)30(20)11-16-3-5-17(25)6-4-16/h3-10,32-33H,11-14H2,1-2H3,(H,27,28,34) TXQMGAVZZZNYLE-UHFFFAOYSA-N 266838 US9718790, I-2576 P2X purinoceptor 3 Homo sapiens 3.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266838 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266838&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278418 377005709 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506406 Cc1nsc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(C[C@@H](O)CO)c(=O)n2Cc2ccc(Cl)cc2)n1 266839 US9718790, I-2577 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266839 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266839&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278377 377005710 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506407 CCOC(=O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccon3)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H19ClFN5O6/c1-2-34-20(31)13-30-22(32)27-21(29(23(30)33)12-14-3-5-15(24)6-4-14)26-16-7-8-18(17(25)11-16)36-19-9-10-35-28-19/h3-11H,2,12-13H2,1H3,(H,26,27,32) HSHFSDFLVIXPSP-UHFFFAOYSA-N 266840 US9718790, I-2578 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266840 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266840&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020628 377005711 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506408 Cc1nsc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(CC(O)=O)c(=O)n2Cc2ccc(Cl)cc2)n1 InChI=1S/C21H17ClN6O5S/c1-12-23-20(34-26-12)33-16-8-6-15(7-9-16)24-18-25-19(31)28(11-17(29)30)21(32)27(18)10-13-2-4-14(22)5-3-13/h2-9H,10-11H2,1H3,(H,29,30)(H,24,25,31) WQQDZOQABUETJZ-UHFFFAOYSA-N 266841 US9718790, I-2579 P2X purinoceptor 3 Homo sapiens 71.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266841 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266841&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020590 377005712 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506409 OC(=O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccon3)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C21H15ClFN5O6/c22-13-3-1-12(2-4-13)10-27-19(25-20(31)28(21(27)32)11-18(29)30)24-14-5-6-16(15(23)9-14)34-17-7-8-33-26-17/h1-9H,10-11H2,(H,29,30)(H,24,25,31) ZMMTWYDYDXEHGX-UHFFFAOYSA-N 266842 US9718790, I-2580 P2X purinoceptor 3 Homo sapiens 204 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266842 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266842&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278639 377005713 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506410 CNC(=O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3nc(C)ns3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C22H20ClN7O4S/c1-13-25-21(35-28-13)34-17-9-7-16(8-10-17)26-19-27-20(32)30(12-18(31)24-2)22(33)29(19)11-14-3-5-15(23)6-4-14/h3-10H,11-12H2,1-2H3,(H,24,31)(H,26,27,32) IRJBTIHJDBNTNL-UHFFFAOYSA-N 266843 US9718790, I-2581 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266843 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266843&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021196 377005714 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506411 OCC(CO)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(F)n3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H23ClFN5O5/c26-18-6-4-16(5-7-18)12-31-23(30-24(35)32(25(31)36)13-17(14-33)15-34)28-19-8-10-20(11-9-19)37-22-3-1-2-21(27)29-22/h1-11,17,33-34H,12-15H2,(H,28,30,35) JZAFTMOKPDYWCB-UHFFFAOYSA-N 266844 US9718790, I-2582 P2X purinoceptor 3 Homo sapiens 3.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266844 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266844&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021147 377005715 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506412 OCC(CO)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(F)n3)cc2)n(Cc2ccc(F)cc2)c1=O InChI=1S/C25H23F2N5O5/c26-18-6-4-16(5-7-18)12-31-23(30-24(35)32(25(31)36)13-17(14-33)15-34)28-19-8-10-20(11-9-19)37-22-3-1-2-21(27)29-22/h1-11,17,33-34H,12-15H2,(H,28,30,35) REBFASGIABASBX-UHFFFAOYSA-N 266845 US9718790, I-2583 P2X purinoceptor 3 Homo sapiens 15.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266845 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266845&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021167 377005716 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506413 NC(=O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(F)n3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H18ClFN6O4/c24-15-6-4-14(5-7-15)12-30-21(29-22(33)31(23(30)34)13-19(26)32)27-16-8-10-17(11-9-16)35-20-3-1-2-18(25)28-20/h1-11H,12-13H2,(H2,26,32)(H,27,29,33) RKHBLGOBDJQRNL-UHFFFAOYSA-N 266846 US9718790, I-2584 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266846 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266846&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020340 377005717 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506414 CNC(=O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(F)n3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H20ClFN6O4/c1-27-20(33)14-32-23(34)30-22(31(24(32)35)13-15-5-7-16(25)8-6-15)28-17-9-11-18(12-10-17)36-21-4-2-3-19(26)29-21/h2-12H,13-14H2,1H3,(H,27,33)(H,28,30,34) PODHJXMPVBJOEQ-UHFFFAOYSA-N 266847 US9718790, I-2585 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266847 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266847&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020256 377005718 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506415 NC(=O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccon3)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C21H16ClFN6O5/c22-13-3-1-12(2-4-13)10-28-19(26-20(31)29(21(28)32)11-17(24)30)25-14-5-6-16(15(23)9-14)34-18-7-8-33-27-18/h1-9H,10-11H2,(H2,24,30)(H,25,26,31) FULOWXGSSSIZDZ-UHFFFAOYSA-N 266848 US9718790, I-2586 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266848 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266848&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020358 377005719 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506416 CNC(=O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccon3)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C22H18ClFN6O5/c1-25-18(31)12-30-21(32)27-20(29(22(30)33)11-13-2-4-14(23)5-3-13)26-15-6-7-17(16(24)10-15)35-19-8-9-34-28-19/h2-10H,11-12H2,1H3,(H,25,31)(H,26,27,32) WBLZXFFUUQIOMK-UHFFFAOYSA-N 266849 US9718790, I-2587 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266849 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266849&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020293 377005720 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506417 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccnc(NCCO)c3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H25ClN6O4/c1-2-31-24(34)30-23(32(25(31)35)16-17-3-5-18(26)6-4-17)29-19-7-9-20(10-8-19)36-21-11-12-27-22(15-21)28-13-14-33/h3-12,15,33H,2,13-14,16H2,1H3,(H,27,28)(H,29,30,34) IEAXUQVTOHJVKN-UHFFFAOYSA-N 266850 US9718790, I-2588 P2X purinoceptor 3 Homo sapiens 11.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266850 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266850&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020357 377005721 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506418 Cc1nsc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(CC(N)=O)c(=O)n2Cc2ccc(Cl)cc2)n1 InChI=1S/C21H18ClN7O4S/c1-12-24-20(34-27-12)33-16-8-6-15(7-9-16)25-18-26-19(31)29(11-17(23)30)21(32)28(18)10-13-2-4-14(22)5-3-13/h2-9H,10-11H2,1H3,(H2,23,30)(H,25,26,31) YQABNIXPHFPYSU-UHFFFAOYSA-N 266851 US9718790, I-2589 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266851 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266851&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020257 377005722 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506419 CNC(=O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccon3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C22H19ClN6O5/c1-24-18(30)13-29-21(31)26-20(28(22(29)32)12-14-2-4-15(23)5-3-14)25-16-6-8-17(9-7-16)34-19-10-11-33-27-19/h2-11H,12-13H2,1H3,(H,24,30)(H,25,26,31) XDVWSESDTHYWKC-UHFFFAOYSA-N 266852 US9718790, I-2590 P2X purinoceptor 3 Homo sapiens 17.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266852 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266852&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020350 377005723 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506420 CCn1c(=O)[nH]\c(=N/c2cccc(Oc3cccc(n3)C#N)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H19ClN6O3/c1-2-30-23(32)29-22(31(24(30)33)15-16-9-11-17(25)12-10-16)28-18-5-3-7-20(13-18)34-21-8-4-6-19(14-26)27-21/h3-13H,2,15H2,1H3,(H,28,29,32) VWDMNHZQEBUWMC-UHFFFAOYSA-N 266853 US9718790, I-2591 P2X purinoceptor 3 Homo sapiens 51.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266853 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266853&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278419 377005724 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506421 CCn1c(=O)[nH]\c(=N/c2cccc(Oc3cccc(n3)C(O)=O)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H20ClN5O5/c1-2-29-23(33)28-22(30(24(29)34)14-15-9-11-16(25)12-10-15)26-17-5-3-6-18(13-17)35-20-8-4-7-19(27-20)21(31)32/h3-13H,2,14H2,1H3,(H,31,32)(H,26,28,33) PHRJTMOBHMYNGQ-UHFFFAOYSA-N 266854 US9718790, I-2592 P2X purinoceptor 3 Homo sapiens 350 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266854 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266854&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021158 377005725 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506422 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(n3)C(=O)NC#N)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H20ClN7O4/c1-2-32-24(35)31-23(33(25(32)36)14-16-6-8-17(26)9-7-16)29-18-10-12-19(13-11-18)37-21-5-3-4-20(30-21)22(34)28-15-27/h3-13H,2,14H2,1H3,(H,28,34)(H,29,31,35) UYTRSEYPRRQUDE-UHFFFAOYSA-N 266855 US9718790, I-2593 P2X purinoceptor 3 Homo sapiens 1.000 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266855 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266855&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278280 377005726 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506423 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3noc(n3)C3CC3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H21ClN6O4/c1-2-29-22(31)27-20(30(23(29)32)13-14-3-7-16(24)8-4-14)25-17-9-11-18(12-10-17)33-21-26-19(34-28-21)15-5-6-15/h3-4,7-12,15H,2,5-6,13H2,1H3,(H,25,27,31) FCPREDGIJLIBCN-UHFFFAOYSA-N 266856 US9718790, I-2594 P2X purinoceptor 3 Homo sapiens 75.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266856 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266856&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021093 377005727 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506424 OCC(CO)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3noc(n3)C3CC3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H25ClN6O6/c26-18-5-1-15(2-6-18)11-31-22(29-24(35)32(25(31)36)12-16(13-33)14-34)27-19-7-9-20(10-8-19)37-23-28-21(38-30-23)17-3-4-17/h1-2,5-10,16-17,33-34H,3-4,11-14H2,(H,27,29,35) BDSNHRLYMKCBOZ-UHFFFAOYSA-N 266857 US9718790, I-2595 P2X purinoceptor 3 Homo sapiens 27.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266857 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266857&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021114 377005728 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506425 OC[C@@H](O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3noc(n3)C3CC3)cc2)n(Cc2ccc(Cl)cc2)c1=O 266858 US9718790, I-2596 P2X purinoceptor 3 Homo sapiens 51.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266858 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266858&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020341 377005729 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506426 CCn1c(=O)[nH]\c(=N/c2ccc(Sc3ccc(cc3)C(=O)OC)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H23ClN4O4S/c1-3-30-25(33)29-24(31(26(30)34)16-17-4-8-19(27)9-5-17)28-20-10-14-22(15-11-20)36-21-12-6-18(7-13-21)23(32)35-2/h4-15H,3,16H2,1-2H3,(H,28,29,33) IXANIWPUGZQDEQ-UHFFFAOYSA-N 266859 US9718790, I-2597 P2X purinoceptor 3 Homo sapiens 215 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266859 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266859&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020295 377005730 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506427 CCn1c(=O)[nH]\c(=N/c2ccc(Sc3nc[nH]n3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C20H18ClN7O2S/c1-2-27-19(29)25-17(28(20(27)30)11-13-3-5-14(21)6-4-13)24-15-7-9-16(10-8-15)31-18-22-12-23-26-18/h3-10,12H,2,11H2,1H3,(H,22,23,26)(H,24,25,29) AVEHLQSOQHQYEM-UHFFFAOYSA-N 266860 US9718790, I-2598 P2X purinoceptor 3 Homo sapiens 341 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266860 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266860&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020323 377005731 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506428 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccnnc3)cc2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C23H22N6O3/c1-3-28-22(30)27-21(29(23(28)31)15-17-6-4-16(2)5-7-17)26-18-8-10-19(11-9-18)32-20-12-13-24-25-14-20/h4-14H,3,15H2,1-2H3,(H,26,27,30) KTFMPJODSNEOQU-UHFFFAOYSA-N 266861 US9718790, I-2599 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266861 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266861&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020345 377005732 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506429 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccnnc3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C22H19ClN6O3/c1-2-28-21(30)27-20(29(22(28)31)14-15-3-5-16(23)6-4-15)26-17-7-9-18(10-8-17)32-19-11-12-24-25-13-19/h3-13H,2,14H2,1H3,(H,26,27,30) BFJLMGVKVIKXHH-UHFFFAOYSA-N 266862 US9718790, I-2600 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266862 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266862&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020656 377005733 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506430 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(nn3)C#N)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H18ClN7O3/c1-2-30-22(32)27-21(31(23(30)33)14-15-3-5-16(24)6-4-15)26-17-7-10-19(11-8-17)34-20-12-9-18(13-25)28-29-20/h3-12H,2,14H2,1H3,(H,26,27,32) YYRVDCMDEOJPRZ-UHFFFAOYSA-N 266863 US9718790, I-2601 P2X purinoceptor 3 Homo sapiens 12.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266863 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266863&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278445 377005734 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506431 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(n3)-c3nnn[nH]3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H20ClN9O3/c1-2-33-23(35)28-22(34(24(33)36)14-15-6-8-16(25)9-7-15)26-17-10-12-18(13-11-17)37-20-5-3-4-19(27-20)21-29-31-32-30-21/h3-13H,2,14H2,1H3,(H,26,28,35)(H,29,30,31,32) XYZDEONWFPJCEJ-UHFFFAOYSA-N 266864 US9718790, I-2602 P2X purinoceptor 3 Homo sapiens 2.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266864 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266864&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278281 377005735 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506432 CCn1c(=O)[nH]\c(=N/c2ccc(Sc3ccc(cc3)C(O)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H21ClN4O4S/c1-2-29-24(33)28-23(30(25(29)34)15-16-3-7-18(26)8-4-16)27-19-9-13-21(14-10-19)35-20-11-5-17(6-12-20)22(31)32/h3-14H,2,15H2,1H3,(H,31,32)(H,27,28,33) JTUJADXHHYCUIK-UHFFFAOYSA-N 266865 US9718790, I-2603 P2X purinoceptor 3 Homo sapiens 125 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266865 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266865&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020625 377005736 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506433 Clc1ccc(Cn2c(=O)n(CC(=O)NC#N)c(=O)[nH]\c2=N/c2ccc(Oc3ccon3)cc2)cc1 InChI=1S/C22H16ClN7O5/c23-15-3-1-14(2-4-15)11-29-20(27-21(32)30(22(29)33)12-18(31)25-13-24)26-16-5-7-17(8-6-16)35-19-9-10-34-28-19/h1-10H,11-12H2,(H,25,31)(H,26,27,32) OUBBSYMWCSPNQR-UHFFFAOYSA-N 266866 US9718790, I-2604 P2X purinoceptor 3 Homo sapiens 21.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266866 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266866&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945705 377005737 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506434 Cc1nsc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(CC(CO)CO)c(=O)n2Cc2ccc(F)cc2)n1 InChI=1S/C23H23FN6O5S/c1-14-25-22(36-28-14)35-19-8-6-18(7-9-19)26-20-27-21(33)30(11-16(12-31)13-32)23(34)29(20)10-15-2-4-17(24)5-3-15/h2-9,16,31-32H,10-13H2,1H3,(H,26,27,33) KFMQLKCQFHYGPW-UHFFFAOYSA-N 266867 US9718790, I-2605 P2X purinoceptor 3 Homo sapiens 14.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266867 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266867&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278253 377005738 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506435 Cc1nsc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(CCCO)c(=O)n2Cc2ccc(F)cc2)n1 InChI=1S/C22H21FN6O4S/c1-14-24-21(34-27-14)33-18-9-7-17(8-10-18)25-19-26-20(31)28(11-2-12-30)22(32)29(19)13-15-3-5-16(23)6-4-15/h3-10,30H,2,11-13H2,1H3,(H,25,26,31) NSNYPJGODLOVIM-UHFFFAOYSA-N 266868 US9718790, I-2606 P2X purinoceptor 3 Homo sapiens 14.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266868 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266868&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945655 377005739 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506436 Cc1nsc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(C[C@H](O)CO)c(=O)n2Cc2ccc(F)cc2)n1 266869 US9718790, I-2607 P2X purinoceptor 3 Homo sapiens 20.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266869 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266869&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278254 377005740 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506438 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ncc(s3)C(N)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C22H19ClN6O4S/c1-2-28-20(31)27-19(29(22(28)32)12-13-3-5-14(23)6-4-13)26-15-7-9-16(10-8-15)33-21-25-11-17(34-21)18(24)30/h3-11H,2,12H2,1H3,(H2,24,30)(H,26,27,31) QRYANJIAHZRQPP-UHFFFAOYSA-N 266870 US9718790, I-2609 P2X purinoceptor 3 Homo sapiens 2.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266870 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266870&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278255 377005741 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506439 Cc1cccc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(CC(CO)CO)c(=O)n2Cc2ccc(Cl)cc2)n1 InChI=1S/C26H26ClN5O5/c1-17-3-2-4-23(28-17)37-22-11-9-21(10-12-22)29-24-30-25(35)32(14-19(15-33)16-34)26(36)31(24)13-18-5-7-20(27)8-6-18/h2-12,19,33-34H,13-16H2,1H3,(H,29,30,35) DWUDWHBPIWFNIF-UHFFFAOYSA-N 266871 US9718790, I-2610 P2X purinoceptor 3 Homo sapiens 12.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266871 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266871&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019839 377005742 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506440 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cccnn3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C22H19ClN6O3/c1-2-28-21(30)26-20(29(22(28)31)14-15-5-7-16(23)8-6-15)25-17-9-11-18(12-10-17)32-19-4-3-13-24-27-19/h3-13H,2,14H2,1H3,(H,25,26,30) GRDSLEUNVYNSMS-UHFFFAOYSA-N 266872 US9718790, I-2611 P2X purinoceptor 3 Homo sapiens 14.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266872 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266872&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019908 377005743 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506441 CC(CO)(CO)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cccnn3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H25ClN6O5/c1-25(15-33,16-34)14-32-23(35)29-22(31(24(32)36)13-17-4-6-18(26)7-5-17)28-19-8-10-20(11-9-19)37-21-3-2-12-27-30-21/h2-12,33-34H,13-16H2,1H3,(H,28,29,35) RDZAYZLBRYGDFJ-UHFFFAOYSA-N 266873 US9718790, I-2612 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266873 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266873&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945473 377005744 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506442 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(cc3)C#N)nc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H19ClN6O3/c1-2-30-23(32)29-22(31(24(30)33)15-17-3-7-18(25)8-4-17)28-19-9-12-21(27-14-19)34-20-10-5-16(13-26)6-11-20/h3-12,14H,2,15H2,1H3,(H,28,29,32) GMBVKAXNOUYMSI-UHFFFAOYSA-N 266874 US9718790, I-2613 P2X purinoceptor 3 Homo sapiens 137 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266874 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266874&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945591 377005745 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506443 CCOC(=O)CNc1ccc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(CC)c(=O)n2Cc2ccc(Cl)cc2)cn1 InChI=1S/C27H27ClN6O5/c1-3-33-26(36)32-25(34(27(33)37)17-18-5-7-19(28)8-6-18)31-20-9-11-21(12-10-20)39-22-13-14-23(29-15-22)30-16-24(35)38-4-2/h5-15H,3-4,16-17H2,1-2H3,(H,29,30)(H,31,32,36) KNSWHONAMWDVKY-UHFFFAOYSA-N 266875 US9718790, I-2614 P2X purinoceptor 3 Homo sapiens 27.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266875 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266875&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945615 377005746 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506444 CC1(Cn2c(=O)[nH]\c(=N/c3ccc(OCC4CC4)cc3)n(Cc3ccc(Cl)cc3)c2=O)COC(C)(C)OC1 InChI=1S/C28H33ClN4O5/c1-27(2)37-17-28(3,18-38-27)16-33-25(34)31-24(32(26(33)35)14-19-6-8-21(29)9-7-19)30-22-10-12-23(13-11-22)36-15-20-4-5-20/h6-13,20H,4-5,14-18H2,1-3H3,(H,30,31,34) UFYCYQMBFPUZRC-UHFFFAOYSA-N 266876 US9718790, I-2615 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266876 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266876&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020360 377005747 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506445 CC(CO)(CO)Cn1c(=O)[nH]\c(=N/c2ccc(OCC3CC3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H29ClN4O5/c1-25(15-31,16-32)14-30-23(33)28-22(29(24(30)34)12-17-4-6-19(26)7-5-17)27-20-8-10-21(11-9-20)35-13-18-2-3-18/h4-11,18,31-32H,2-3,12-16H2,1H3,(H,27,28,33) SAPZFFUCNTTXDL-UHFFFAOYSA-N 266877 US9718790, I-2616 P2X purinoceptor 3 Homo sapiens 12.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266877 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266877&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020658 377005748 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506446 CC(CO)(CO)Cn1c(=O)[nH]\c(=N/c2ccc(OCC3CC3)cc2)n(Cc2ccc(F)cc2)c1=O InChI=1S/C25H29FN4O5/c1-25(15-31,16-32)14-30-23(33)28-22(29(24(30)34)12-17-4-6-19(26)7-5-17)27-20-8-10-21(11-9-20)35-13-18-2-3-18/h4-11,18,31-32H,2-3,12-16H2,1H3,(H,27,28,33) CLMPCJCMWKLMGR-UHFFFAOYSA-N 266878 US9718790, I-2617 P2X purinoceptor 3 Homo sapiens 42.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266878 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266878&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020593 377005749 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506447 CCOC(=O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3nccs3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H20ClN5O5S/c1-2-33-19(30)14-29-21(31)27-20(28(23(29)32)13-15-3-5-16(24)6-4-15)26-17-7-9-18(10-8-17)34-22-25-11-12-35-22/h3-12H,2,13-14H2,1H3,(H,26,27,31) YLWYRWKEEMYQPM-UHFFFAOYSA-N 266879 US9718790, I-2618 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266879 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266879&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945512 377005750 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506448 CCOC(=O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ncc(C)s3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H22ClN5O5S/c1-3-34-20(31)14-30-22(32)28-21(29(24(30)33)13-16-4-6-17(25)7-5-16)27-18-8-10-19(11-9-18)35-23-26-12-15(2)36-23/h4-12H,3,13-14H2,1-2H3,(H,27,28,32) YSDRJRWYKWDHOC-UHFFFAOYSA-N 266880 US9718790, I-2619 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266880&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020595 377005751 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506449 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(cc3)C(N)=O)nc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H21ClN6O4/c1-2-30-23(33)29-22(31(24(30)34)14-15-3-7-17(25)8-4-15)28-18-9-12-20(27-13-18)35-19-10-5-16(6-11-19)21(26)32/h3-13H,2,14H2,1H3,(H2,26,32)(H,28,29,33) RPENHEWFRZJPIF-UHFFFAOYSA-N 266881 US9718790, I-2620 P2X purinoceptor 3 Homo sapiens 110 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266881 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266881&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020059 377005752 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506450 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(cc3)C(O)=O)nc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H20ClN5O5/c1-2-29-23(33)28-22(30(24(29)34)14-15-3-7-17(25)8-4-15)27-18-9-12-20(26-13-18)35-19-10-5-16(6-11-19)21(31)32/h3-13H,2,14H2,1H3,(H,31,32)(H,27,28,33) AVGQVYOLDFICAG-UHFFFAOYSA-N 266882 US9718790, I-2621 P2X purinoceptor 3 Homo sapiens 265 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266882 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266882&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020061 377005753 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506451 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(NCC(O)=O)nc3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H23ClN6O5/c1-2-31-24(35)30-23(32(25(31)36)15-16-3-5-17(26)6-4-16)29-18-7-9-19(10-8-18)37-20-11-12-21(27-13-20)28-14-22(33)34/h3-13H,2,14-15H2,1H3,(H,27,28)(H,33,34)(H,29,30,35) RJTQZTUNPWVZEB-UHFFFAOYSA-N 266883 US9718790, I-2622 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266883 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266883&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020051 377005754 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506453 Cc1cnc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(CC(O)=O)c(=O)n2Cc2ccc(Cl)cc2)s1 InChI=1S/C22H18ClN5O5S/c1-13-10-24-21(34-13)33-17-8-6-16(7-9-17)25-19-26-20(31)28(12-18(29)30)22(32)27(19)11-14-2-4-15(23)5-3-14/h2-10H,11-12H2,1H3,(H,29,30)(H,25,26,31) VZDUORPQHDQLBQ-UHFFFAOYSA-N 266884 US9718790, I-2624 P2X purinoceptor 3 Homo sapiens 368 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266884 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266884&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020098 377005755 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506454 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(NCC(N)=O)nc3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H24ClN7O4/c1-2-32-24(35)31-23(33(25(32)36)15-16-3-5-17(26)6-4-16)30-18-7-9-19(10-8-18)37-20-11-12-22(28-13-20)29-14-21(27)34/h3-13H,2,14-15H2,1H3,(H2,27,34)(H,28,29)(H,30,31,35) HUVSUFGWIKNADN-UHFFFAOYSA-N 266885 US9718790, I-2625 P2X purinoceptor 3 Homo sapiens 3.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266885 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266885&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020062 377005756 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506455 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(NCC(=O)NC)nc3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H26ClN7O4/c1-3-33-25(36)32-24(34(26(33)37)16-17-4-6-18(27)7-5-17)31-19-8-10-20(11-9-19)38-21-12-13-22(29-14-21)30-15-23(35)28-2/h4-14H,3,15-16H2,1-2H3,(H,28,35)(H,29,30)(H,31,32,36) JYHZXVASMQBGON-UHFFFAOYSA-N 266886 US9718790, I-2626 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266886 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266886&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020053 377005757 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506456 CCOC(=O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccon3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H20ClN5O6/c1-2-33-20(30)14-29-22(31)26-21(28(23(29)32)13-15-3-5-16(24)6-4-15)25-17-7-9-18(10-8-17)35-19-11-12-34-27-19/h3-12H,2,13-14H2,1H3,(H,25,26,31) KAOCGUIMUZKYSA-UHFFFAOYSA-N 266887 US9718790, I-2627 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266887 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266887&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020187 377005758 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506457 CCOC(=O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ncns3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C22H19ClN6O5S/c1-2-33-18(30)12-29-20(31)27-19(28(22(29)32)11-14-3-5-15(23)6-4-14)26-16-7-9-17(10-8-16)34-21-24-13-25-35-21/h3-10,13H,2,11-12H2,1H3,(H,26,27,31) RDOUXCDKYUIQJV-UHFFFAOYSA-N 266888 US9718790, I-2628 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266888 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266888&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020291 377005759 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506458 CCOC(=O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cnsn3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C22H19ClN6O5S/c1-2-33-19(30)13-29-21(31)26-20(28(22(29)32)12-14-3-5-15(23)6-4-14)25-16-7-9-17(10-8-16)34-18-11-24-35-27-18/h3-11H,2,12-13H2,1H3,(H,25,26,31) BBZGWPXHGBRBOU-UHFFFAOYSA-N 266889 US9718790, I-2629 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266889 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266889&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020254 377005760 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506459 CC1(C)OCC(C)(Cn2c(=O)[nH]\c(=N/c3ccc(Oc4ccon4)cc3)n(Cc3ccc(Cl)cc3)c2=O)CO1 InChI=1S/C27H28ClN5O6/c1-26(2)36-16-27(3,17-37-26)15-33-24(34)30-23(32(25(33)35)14-18-4-6-19(28)7-5-18)29-20-8-10-21(11-9-20)39-22-12-13-38-31-22/h4-13H,14-17H2,1-3H3,(H,29,30,34) RRDWHPSAWKNMHU-UHFFFAOYSA-N 266890 US9718790, I-2630 P2X purinoceptor 3 Homo sapiens 3.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266890 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266890&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020292 377005761 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506460 CCn1c(=O)[nH]\c(=N/c2ccc(cc2)S(=O)c2ccc(cc2)C(O)=O)n(Cc2ccc(Cl)cc2)c1=O 266891 US9718790, I-2631 P2X purinoceptor 3 Homo sapiens 475 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266891 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266891&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020255 377005762 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506461 COC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(n3)C#N)cc2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C27H24N6O5/c1-18-6-8-19(9-7-18)17-33-25(31-26(35)32(27(33)36)15-14-24(34)37-2)30-20-10-12-22(13-11-20)38-23-5-3-4-21(16-28)29-23/h3-13H,14-15,17H2,1-2H3,(H,30,31,35) XTIHGIZSFRXFDJ-UHFFFAOYSA-N 266892 US9718790, I-2633 P2X purinoceptor 3 Homo sapiens 2.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266892 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266892&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945709 377005763 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506462 Cc1ccc(Cn2c(=O)n(CCC(O)=O)c(=O)[nH]\c2=N/c2ccc(Oc3cccc(n3)C#N)cc2)cc1 InChI=1S/C26H22N6O5/c1-17-5-7-18(8-6-17)16-32-24(30-25(35)31(26(32)36)14-13-23(33)34)29-19-9-11-21(12-10-19)37-22-4-2-3-20(15-27)28-22/h2-12H,13-14,16H2,1H3,(H,33,34)(H,29,30,35) XMKWCNUVDYIECM-UHFFFAOYSA-N 266893 US9718790, I-2634 P2X purinoceptor 3 Homo sapiens 11.0 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266893 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266893&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945729 377005764 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 506463 Cc1ccc(Cn2c(=O)n(CCC(O)=O)c(=O)[nH]\c2=N/c2ccc(Oc3ccc(cn3)C#N)cc2)cc1 InChI=1S/C26H22N6O5/c1-17-2-4-18(5-3-17)16-32-24(30-25(35)31(26(32)36)13-12-23(33)34)29-20-7-9-21(10-8-20)37-22-11-6-19(14-27)15-28-22/h2-11,15H,12-13,16H2,1H3,(H,33,34)(H,29,30,35) GTJMSVRAEUYRRR-UHFFFAOYSA-N 266894 US9718790, I-2635 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q22809KB aid1795343 US9718790 Kai, H; Horiguchi, T; Asahi, K; Fujii, Y Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266894 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266894&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945514 377005765 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490774 CCn1c(=O)cc(Nc2ccc(Oc3ncc(s3)C(O)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H19ClN4O5S/c1-2-27-20(29)11-19(28(23(27)32)13-14-3-5-15(24)6-4-14)26-16-7-9-17(10-8-16)33-22-25-12-18(34-22)21(30)31/h3-12,26H,2,13H2,1H3,(H,30,31) LBKBEBNJNGGBCD-UHFFFAOYSA-N 244265 US9550763, Compound I-013 P2X purinoceptor 3 Homo sapiens 2.00 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244265 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244265&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823065 376221964 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490775 CCOC(=O)c1cnc(Nc2ccc3oc(CC)c(C)c3c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H24ClN3O4/c1-4-21-15(3)19-12-18(10-11-22(19)33-21)28-25-27-13-20(24(31)32-5-2)23(30)29(25)14-16-6-8-17(26)9-7-16/h6-13H,4-5,14H2,1-3H3,(H,27,28) LWWLEQDPRMGRQX-UHFFFAOYSA-N 244266 US9550763, Compound I-014 P2X purinoceptor 3 Homo sapiens 146 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244266 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244266&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 71728268 376221965 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490776 CCOC(=O)c1cn(Cc2ccc(Cl)cc2)c(Nc2ccc3oc(CC)c(C)c3c2)nc1=O InChI=1S/C25H24ClN3O4/c1-4-21-15(3)19-12-18(10-11-22(19)33-21)27-25-28-23(30)20(24(31)32-5-2)14-29(25)13-16-6-8-17(26)9-7-16/h6-12,14H,4-5,13H2,1-3H3,(H,27,28,30) YXNGORFAHOZDPH-UHFFFAOYSA-N 244267 US9550763, Compound I-015 P2X purinoceptor 3 Homo sapiens 160 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244267 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244267&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 89745364 376221966 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490777 CCc1oc2ccc(Nc3ncc(C(O)=O)c(=O)n3Cc3ccc(Cl)cc3)cc2c1C InChI=1S/C23H20ClN3O4/c1-3-19-13(2)17-10-16(8-9-20(17)31-19)26-23-25-11-18(22(29)30)21(28)27(23)12-14-4-6-15(24)7-5-14/h4-11H,3,12H2,1-2H3,(H,25,26)(H,29,30) LDRMBHAHPIPAPC-UHFFFAOYSA-N 244268 US9550763, Compound I-016 P2X purinoceptor 3 Homo sapiens 150 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244268 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244268&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 89745122 376221967 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490778 CCc1oc2ccc(Nc3nc(=O)c(cn3Cc3ccc(Cl)cc3)C(O)=O)cc2c1C InChI=1S/C23H20ClN3O4/c1-3-19-13(2)17-10-16(8-9-20(17)31-19)25-23-26-21(28)18(22(29)30)12-27(23)11-14-4-6-15(24)7-5-14/h4-10,12H,3,11H2,1-2H3,(H,29,30)(H,25,26,28) MEERWLCJIAHKHJ-UHFFFAOYSA-N 244269 US9550763, Compound I-017 P2X purinoceptor 3 Homo sapiens 401 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244269 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244269&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 89745121 376221968 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490779 CCOC(=O)c1c[nH]\c(=N/c2ccc(Oc3cccc(F)n3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H20ClFN4O4/c1-2-34-24(33)20-14-28-25(31(23(20)32)15-16-6-8-17(26)9-7-16)29-18-10-12-19(13-11-18)35-22-5-3-4-21(27)30-22/h3-14H,2,15H2,1H3,(H,28,29) NSORLAWLCFCNJZ-UHFFFAOYSA-N 244270 US9550763, Compound I-018 P2X purinoceptor 3 Homo sapiens 13.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244270 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244270&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823066 376221969 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490780 CCc1oc2ccc(Nc3ncc(C(=O)NC4CCOCC4)c(=O)n3Cc3ccc(Cl)cc3)cc2c1C InChI=1S/C28H29ClN4O4/c1-3-24-17(2)22-14-21(8-9-25(22)37-24)32-28-30-15-23(26(34)31-20-10-12-36-13-11-20)27(35)33(28)16-18-4-6-19(29)7-5-18/h4-9,14-15,20H,3,10-13,16H2,1-2H3,(H,30,32)(H,31,34) ATUBYXGEDFJIIJ-UHFFFAOYSA-N 244271 US9550763, Compound I-019 P2X purinoceptor 3 Homo sapiens 135 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244271 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244271&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 89745134 376221970 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490781 CCc1oc2ccc(Nc3ncc(C(N)=O)c(=O)n3Cc3ccc(Cl)cc3)cc2c1C InChI=1S/C23H21ClN4O3/c1-3-19-13(2)17-10-16(8-9-20(17)31-19)27-23-26-11-18(21(25)29)22(30)28(23)12-14-4-6-15(24)7-5-14/h4-11H,3,12H2,1-2H3,(H2,25,29)(H,26,27) NOITWRASKKJWDK-UHFFFAOYSA-N 244272 US9550763, Compound I-020 P2X purinoceptor 3 Homo sapiens 50.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244272 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244272&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 89745127 376221971 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490782 CCc1oc2ccc(Nc3nc(=O)c(cn3Cc3ccc(Cl)cc3)C(=O)NC3CCOCC3)cc2c1C InChI=1S/C28H29ClN4O4/c1-3-24-17(2)22-14-21(8-9-25(22)37-24)31-28-32-27(35)23(26(34)30-20-10-12-36-13-11-20)16-33(28)15-18-4-6-19(29)7-5-18/h4-9,14,16,20H,3,10-13,15H2,1-2H3,(H,30,34)(H,31,32,35) NZXMDVHRUOAPER-UHFFFAOYSA-N 244273 US9550763, Compound I-021 P2X purinoceptor 3 Homo sapiens 20.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244273 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244273&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 89745126 376221972 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490783 CCc1oc2ccc(Nc3nc(=O)c(cn3Cc3ccc(Cl)cc3)C(=O)NC(C)C)cc2c1C InChI=1S/C26H27ClN4O3/c1-5-22-16(4)20-12-19(10-11-23(20)34-22)29-26-30-25(33)21(24(32)28-15(2)3)14-31(26)13-17-6-8-18(27)9-7-17/h6-12,14-15H,5,13H2,1-4H3,(H,28,32)(H,29,30,33) KIHAZXSBGKKMMW-UHFFFAOYSA-N 244274 US9550763, Compound I-022 P2X purinoceptor 3 Homo sapiens 94.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244274 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244274&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 89745275 376221973 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490784 CCn1c(=O)cc(Nc2ccc(Oc3cccc(c3)C(O)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H22ClN3O5/c1-2-29-24(31)15-23(30(26(29)34)16-17-6-8-19(27)9-7-17)28-20-10-12-21(13-11-20)35-22-5-3-4-18(14-22)25(32)33/h3-15,28H,2,16H2,1H3,(H,32,33) UDSLUNHVVMLZDO-UHFFFAOYSA-N 244275 US9550763, Compound I-023 P2X purinoceptor 3 Homo sapiens 3.00 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244275 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244275&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823067 376221974 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490785 CCn1c(=O)cc(Nc2ccc(Oc3cccc(c3)C(N)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H23ClN4O4/c1-2-30-24(32)15-23(31(26(30)34)16-17-6-8-19(27)9-7-17)29-20-10-12-21(13-11-20)35-22-5-3-4-18(14-22)25(28)33/h3-15,29H,2,16H2,1H3,(H2,28,33) PHYWJKRAYHETRM-UHFFFAOYSA-N 244276 US9550763, Compound I-024 P2X purinoceptor 3 Homo sapiens 14.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244276 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244276&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823068 376221975 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490786 CCn1c(=O)cc(Nc2ccc(Oc3cccc(n3)C(N)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H22ClN5O4/c1-2-30-23(32)14-21(31(25(30)34)15-16-6-8-17(26)9-7-16)28-18-10-12-19(13-11-18)35-22-5-3-4-20(29-22)24(27)33/h3-14,28H,2,15H2,1H3,(H2,27,33) OQOHNZXEVIHZPF-UHFFFAOYSA-N 244277 US9550763, Compound I-025 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244277 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244277&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823069 376221976 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490787 CCn1c(=O)cc(Nc2ccc(Oc3cccc(n3)C(N)=O)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H21ClFN5O4/c1-2-31-23(33)13-21(32(25(31)35)14-15-6-8-16(26)9-7-15)29-17-10-11-20(18(27)12-17)36-22-5-3-4-19(30-22)24(28)34/h3-13,29H,2,14H2,1H3,(H2,28,34) PFBGRKONWVMECU-UHFFFAOYSA-N 244278 US9550763, Compound I-026 P2X purinoceptor 3 Homo sapiens 3.00 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244278 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244278&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823070 376221977 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490788 CCn1c(=O)cc(Nc2ccc(Oc3cccc(n3)C(N)=O)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H24ClN5O4/c1-3-31-24(33)14-22(32(26(31)35)15-17-7-9-18(27)10-8-17)29-19-11-12-21(16(2)13-19)36-23-6-4-5-20(30-23)25(28)34/h4-14,29H,3,15H2,1-2H3,(H2,28,34) KUDRFQHVSHUKDS-UHFFFAOYSA-N 244279 US9550763, Compound I-027 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244279 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244279&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823071 376221978 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490789 CCn1c(=O)cc(Nc2ccc(Oc3cccc(n3)C(O)=O)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H23ClN4O5/c1-3-30-24(32)14-22(31(26(30)35)15-17-7-9-18(27)10-8-17)28-19-11-12-21(16(2)13-19)36-23-6-4-5-20(29-23)25(33)34/h4-14,28H,3,15H2,1-2H3,(H,33,34) BQHLMWCWUSJPKD-UHFFFAOYSA-N 244280 US9550763, Compound I-028 P2X purinoceptor 3 Homo sapiens 1.000 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244280 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244280&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823072 376221979 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490790 OC(=O)c1c[nH]\c(=N/c2ccc(Oc3cccc(F)n3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H16ClFN4O4/c24-15-6-4-14(5-7-15)13-29-21(30)18(22(31)32)12-26-23(29)27-16-8-10-17(11-9-16)33-20-3-1-2-19(25)28-20/h1-12H,13H2,(H,26,27)(H,31,32) ZHIUWMWWVKXROT-UHFFFAOYSA-N 244281 US9550763, Compound I-029 P2X purinoceptor 3 Homo sapiens 236 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244281 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244281&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823073 376221980 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490791 CCc1oc2ccc(cc2c1C)\N=c1/[nH]cc(NC(=O)C2CCOCC2)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C28H29ClN4O4/c1-3-24-17(2)22-14-21(8-9-25(22)37-24)31-28-30-15-23(32-26(34)19-10-12-36-13-11-19)27(35)33(28)16-18-4-6-20(29)7-5-18/h4-9,14-15,19H,3,10-13,16H2,1-2H3,(H,30,31)(H,32,34) SAMKJBBPVAYUEF-UHFFFAOYSA-N 244282 US9550763, Compound I-030 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244282 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244282&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823074 376221981 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490792 CCC(CC)NC(=O)c1cn(Cc2ccc(Cl)cc2)c(Nc2ccc3oc(CC)c(C)c3c2)nc1=O InChI=1S/C28H31ClN4O3/c1-5-20(6-2)30-26(34)23-16-33(15-18-8-10-19(29)11-9-18)28(32-27(23)35)31-21-12-13-25-22(14-21)17(4)24(7-3)36-25/h8-14,16,20H,5-7,15H2,1-4H3,(H,30,34)(H,31,32,35) IMZOSONOIYQZDB-UHFFFAOYSA-N 244283 US9550763, Compound I-031 P2X purinoceptor 3 Homo sapiens 54.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244283 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244283&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 89745131 376221982 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490793 CCc1oc2ccc(Nc3ncc(C(=O)NCCO)c(=O)n3Cc3ccc(Cl)cc3)cc2c1C InChI=1S/C25H25ClN4O4/c1-3-21-15(2)19-12-18(8-9-22(19)34-21)29-25-28-13-20(23(32)27-10-11-31)24(33)30(25)14-16-4-6-17(26)7-5-16/h4-9,12-13,31H,3,10-11,14H2,1-2H3,(H,27,32)(H,28,29) SNSDXXIRMIIMJZ-UHFFFAOYSA-N 244284 US9550763, Compound I-032 P2X purinoceptor 3 Homo sapiens 34.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244284 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244284&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 89745132 376221983 C04080 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490794 CCn1c(=O)cc(Nc2ccc(Oc3cccc(n3)C(O)=O)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H20ClFN4O5/c1-2-30-23(32)13-21(31(25(30)35)14-15-6-8-16(26)9-7-15)28-17-10-11-20(18(27)12-17)36-22-5-3-4-19(29-22)24(33)34/h3-13,28H,2,14H2,1H3,(H,33,34) OCOKRRDUQXLQKT-UHFFFAOYSA-N 244285 US9550763, Compound I-033 P2X purinoceptor 3 Homo sapiens 1.000 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244285 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244285&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 78161127 376221984 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490795 NC(=O)c1c[nH]\c(=N/c2ccc(Oc3cccc(F)n3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H17ClFN5O3/c24-15-6-4-14(5-7-15)13-30-22(32)18(21(26)31)12-27-23(30)28-16-8-10-17(11-9-16)33-20-3-1-2-19(25)29-20/h1-12H,13H2,(H2,26,31)(H,27,28) SAONHLXGVNEEKN-UHFFFAOYSA-N 244286 US9550763, Compound I-034 P2X purinoceptor 3 Homo sapiens 14.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244286 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244286&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823075 376221985 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490796 CCc1oc2ccc(Nc3ncc(C(=O)Nc4ccccn4)c(=O)n3Cc3ccc(Cl)cc3)cc2c1C InChI=1S/C28H24ClN5O3/c1-3-23-17(2)21-14-20(11-12-24(21)37-23)32-28-31-15-22(26(35)33-25-6-4-5-13-30-25)27(36)34(28)16-18-7-9-19(29)10-8-18/h4-15H,3,16H2,1-2H3,(H,31,32)(H,30,33,35) KSMONUDVGAAQPR-UHFFFAOYSA-N 244287 US9550763, Compound I-035 P2X purinoceptor 3 Homo sapiens 190 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244287 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244287&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 89745352 376221986 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490797 CCOC(=O)c1sc(Oc2ccc(Nc3cc(=O)n(CC)c(=O)n3Cc3ccc(Cl)cc3)cc2)nc1C InChI=1S/C26H25ClN4O5S/c1-4-30-22(32)14-21(31(26(30)34)15-17-6-8-18(27)9-7-17)29-19-10-12-20(13-11-19)36-25-28-16(3)23(37-25)24(33)35-5-2/h6-14,29H,4-5,15H2,1-3H3 QXBIYYJVVZJYEA-UHFFFAOYSA-N 244288 US9550763, Compound I-036 P2X purinoceptor 3 Homo sapiens 22.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244288 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244288&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823076 376221987 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490798 OCc1c[nH]\c(=N/c2ccc(Oc3cccc(F)n3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H18ClFN4O3/c24-17-6-4-15(5-7-17)13-29-22(31)16(14-30)12-26-23(29)27-18-8-10-19(11-9-18)32-21-3-1-2-20(25)28-21/h1-12,30H,13-14H2,(H,26,27) YXEANNSNHKVIGS-UHFFFAOYSA-N 244289 US9550763, Compound I-037 P2X purinoceptor 3 Homo sapiens 34.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244289 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244289&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823077 376221988 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490799 NC(=O)c1cccc(Oc2ccc(Nc3ncc(NC(=O)C4CCOCC4)c(=O)n3Cc3ccc(Cl)cc3)cc2)n1 InChI=1S/C29H27ClN6O5/c30-20-6-4-18(5-7-20)17-36-28(39)24(35-27(38)19-12-14-40-15-13-19)16-32-29(36)33-21-8-10-22(11-9-21)41-25-3-1-2-23(34-25)26(31)37/h1-11,16,19H,12-15,17H2,(H2,31,37)(H,32,33)(H,35,38) XJQQDUVNNYSCLN-UHFFFAOYSA-N 244290 US9550763, Compound I-038 P2X purinoceptor 3 Homo sapiens 2.00 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244290 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244290&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 89745169 376221989 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490800 CCn1c(=O)cc(Nc2ccc(Oc3ncc(s3)C(N)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H20ClN5O4S/c1-2-28-20(30)11-19(29(23(28)32)13-14-3-5-15(24)6-4-14)27-16-7-9-17(10-8-16)33-22-26-12-18(34-22)21(25)31/h3-12,27H,2,13H2,1H3,(H2,25,31) AQLHKYUQNXOWLY-UHFFFAOYSA-N 244291 US9550763, Compound I-039 P2X purinoceptor 3 Homo sapiens <4.00 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244291 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244291&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 78161128 376221990 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490801 CCn1c(=O)cc(Nc2ccc(Oc3cccc(n3)C(O)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H21ClN4O5/c1-2-29-23(31)14-21(30(25(29)34)15-16-6-8-17(26)9-7-16)27-18-10-12-19(13-11-18)35-22-5-3-4-20(28-22)24(32)33/h3-14,27H,2,15H2,1H3,(H,32,33) RVZWJVHDWPCVLO-UHFFFAOYSA-N 244292 US9550763, Compound I-040 P2X purinoceptor 3 Homo sapiens 3.00 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244292 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244292&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823078 376221991 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490802 CCn1c(=O)cc(Nc2ccc(Oc3nc(C)c(s3)C(O)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H21ClN4O5S/c1-3-28-20(30)12-19(29(24(28)33)13-15-4-6-16(25)7-5-15)27-17-8-10-18(11-9-17)34-23-26-14(2)21(35-23)22(31)32/h4-12,27H,3,13H2,1-2H3,(H,31,32) PEMZBHWMYAOBDV-UHFFFAOYSA-N 244293 US9550763, Compound I-041 P2X purinoceptor 3 Homo sapiens 3.00 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244293 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244293&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823079 376221992 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490803 Fc1cccc(Oc2ccc(cc2)\N=c2/[nH]cc(C(=O)NC3CCOCC3)c(=O)n2Cc2ccc(Cl)cc2)n1 InChI=1S/C28H25ClFN5O4/c29-19-6-4-18(5-7-19)17-35-27(37)23(26(36)32-21-12-14-38-15-13-21)16-31-28(35)33-20-8-10-22(11-9-20)39-25-3-1-2-24(30)34-25/h1-11,16,21H,12-15,17H2,(H,31,33)(H,32,36) VBCKSKUBZAYROJ-UHFFFAOYSA-N 244294 US9550763, Compound I-042 P2X purinoceptor 3 Homo sapiens 14.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244294 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244294&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823080 376221993 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490804 CCOC(=O)c1cnc(Nc2ccc(Oc3cccc(n3)C(N)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H22ClN5O5/c1-2-36-25(35)20-14-29-26(32(24(20)34)15-16-6-8-17(27)9-7-16)30-18-10-12-19(13-11-18)37-22-5-3-4-21(31-22)23(28)33/h3-14H,2,15H2,1H3,(H2,28,33)(H,29,30) WTESPEZVKMVYFZ-UHFFFAOYSA-N 244295 US9550763, Compound I-043 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244295 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244295&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 89745354 376221994 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490805 CCOC(=O)c1cccc(Oc2ccc(Nc3cc(=O)n(CC)c(=O)n3Cc3ccc(Cl)cc3)nc2)c1 InChI=1S/C27H25ClN4O5/c1-3-31-25(33)15-24(32(27(31)35)17-18-8-10-20(28)11-9-18)30-23-13-12-22(16-29-23)37-21-7-5-6-19(14-21)26(34)36-4-2/h5-16H,3-4,17H2,1-2H3,(H,29,30) FDDFDJMZWBRPAE-UHFFFAOYSA-N 244296 US9550763, Compound I-044 P2X purinoceptor 3 Homo sapiens 103 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244296 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244296&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823081 376221995 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490806 CCc1oc2ccc(cc2c1C)\N=c1/[nH]cc(C=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C23H20ClN3O3/c1-3-20-14(2)19-10-18(8-9-21(19)30-20)26-23-25-11-16(13-28)22(29)27(23)12-15-4-6-17(24)7-5-15/h4-11,13H,3,12H2,1-2H3,(H,25,26) OGFRAYLJRRWGJV-UHFFFAOYSA-N 244297 US9550763, Compound I-045 P2X purinoceptor 3 Homo sapiens 226 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244297 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244297&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823082 376221996 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490807 CCc1oc2ccc(cc2c1C)\N=c1/[nH]cc(CO)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C23H22ClN3O3/c1-3-20-14(2)19-10-18(8-9-21(19)30-20)26-23-25-11-16(13-28)22(29)27(23)12-15-4-6-17(24)7-5-15/h4-11,28H,3,12-13H2,1-2H3,(H,25,26) WSMIIZUBOAEIJC-UHFFFAOYSA-N 244298 US9550763, Compound I-046 P2X purinoceptor 3 Homo sapiens 278 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244298 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244298&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823083 376221997 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490808 CCc1oc2ccc(cc2c1C)\N=c1/[nH]cc(NS(=O)(=O)C2CCOCC2)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C27H29ClN4O5S/c1-3-24-17(2)22-14-20(8-9-25(22)37-24)30-27-29-15-23(31-38(34,35)21-10-12-36-13-11-21)26(33)32(27)16-18-4-6-19(28)7-5-18/h4-9,14-15,21,31H,3,10-13,16H2,1-2H3,(H,29,30) FPUGJUDGNPRXIQ-UHFFFAOYSA-N 244299 US9550763, Compound I-047 P2X purinoceptor 3 Homo sapiens 18.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244299 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244299&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823084 376221998 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490809 CCc1oc2ccc(cc2c1C)\N=c1/[nH]cc(\C=N\N2CCOCC2)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C27H28ClN5O3/c1-3-24-18(2)23-14-22(8-9-25(23)36-24)31-27-29-15-20(16-30-32-10-12-35-13-11-32)26(34)33(27)17-19-4-6-21(28)7-5-19/h4-9,14-16H,3,10-13,17H2,1-2H3,(H,29,31)/b30-16+ NPBMAUFHGNJHMQ-OKCVXOCRSA-N 244300 US9550763, Compound I-048 P2X purinoceptor 3 Homo sapiens 22.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244300 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244300&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823085 376221999 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490810 CCc1oc2ccc(cc2c1C)\N=c1/[nH]cc(CNC2CCOCC2)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C28H31ClN4O3/c1-3-25-18(2)24-14-23(8-9-26(24)36-25)32-28-31-16-20(15-30-22-10-12-35-13-11-22)27(34)33(28)17-19-4-6-21(29)7-5-19/h4-9,14,16,22,30H,3,10-13,15,17H2,1-2H3,(H,31,32) LMRSLPTXBKLCJE-UHFFFAOYSA-N 244301 US9550763, Compound I-049 P2X purinoceptor 3 Homo sapiens 225 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244301 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244301&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823086 376222000 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490811 OC(=O)c1cccc(Oc2ccc(Nc3ncc(C(O)=O)c(=O)n3Cc3ccc(Cl)cc3)cc2)n1 InChI=1S/C24H17ClN4O6/c25-15-6-4-14(5-7-15)13-29-21(30)18(22(31)32)12-26-24(29)27-16-8-10-17(11-9-16)35-20-3-1-2-19(28-20)23(33)34/h1-12H,13H2,(H,26,27)(H,31,32)(H,33,34) UMHAZNVXWSGQFE-UHFFFAOYSA-N 244302 US9550763, Compound I-050 P2X purinoceptor 3 Homo sapiens 67.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244302 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244302&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 89745171 376222001 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490812 CCOC(=O)c1cnc(Nc2ccc(Oc3cccc(n3)C(=O)OC)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C27H23ClN4O6/c1-3-37-25(34)21-15-29-27(32(24(21)33)16-17-7-9-18(28)10-8-17)30-19-11-13-20(14-12-19)38-23-6-4-5-22(31-23)26(35)36-2/h4-15H,3,16H2,1-2H3,(H,29,30) WUZHMOBUIYFLPB-UHFFFAOYSA-N 244303 US9550763, Compound I-051 P2X purinoceptor 3 Homo sapiens 27.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244303 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244303&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 89745176 376222002 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490813 CCn1c(=O)cc(Nc2ccc(Oc3ccc(cc3)C(=O)OC)cn2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H23ClN4O5/c1-3-30-24(32)14-23(31(26(30)34)16-17-4-8-19(27)9-5-17)29-22-13-12-21(15-28-22)36-20-10-6-18(7-11-20)25(33)35-2/h4-15H,3,16H2,1-2H3,(H,28,29) SOQFSSMJLLUDLL-UHFFFAOYSA-N 244304 US9550763, Compound I-052 P2X purinoceptor 3 Homo sapiens 21.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244304 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244304&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823087 376222003 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490814 CCn1c(=O)cc(Nc2ccc(Oc3cccc(c3)C(O)=O)cn2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H21ClN4O5/c1-2-29-23(31)13-22(30(25(29)34)15-16-6-8-18(26)9-7-16)28-21-11-10-20(14-27-21)35-19-5-3-4-17(12-19)24(32)33/h3-14H,2,15H2,1H3,(H,27,28)(H,32,33) PQHXQFNKQSRKRH-UHFFFAOYSA-N 244305 US9550763, Compound I-053 P2X purinoceptor 3 Homo sapiens 20.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244305 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244305&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823088 376222004 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490815 CCn1c(=O)cc(Nc2ccc(Oc3ccc(cc3)C(O)=O)cn2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H21ClN4O5/c1-2-29-23(31)13-22(30(25(29)34)15-16-3-7-18(26)8-4-16)28-21-12-11-20(14-27-21)35-19-9-5-17(6-10-19)24(32)33/h3-14H,2,15H2,1H3,(H,27,28)(H,32,33) PNTASGXTTAQPTI-UHFFFAOYSA-N 244306 US9550763, Compound I-054 P2X purinoceptor 3 Homo sapiens 43.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244306 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244306&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823089 376222005 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490816 CCOC(=O)c1cnc(Nc2ccc(Oc3cccc(n3)C(O)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H21ClN4O6/c1-2-36-25(35)20-14-28-26(31(23(20)32)15-16-6-8-17(27)9-7-16)29-18-10-12-19(13-11-18)37-22-5-3-4-21(30-22)24(33)34/h3-14H,2,15H2,1H3,(H,28,29)(H,33,34) XYFJJEYBXFOCNP-UHFFFAOYSA-N 244307 US9550763, Compound I-055 P2X purinoceptor 3 Homo sapiens 2.00 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244307 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244307&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 89745287 376222006 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490817 CCOC(=O)c1cnc(Oc2ccc(Nc3ncc(C(=O)OCC)c(=O)n3Cc3ccc(Cl)cc3)cc2)s1 InChI=1S/C26H23ClN4O6S/c1-3-35-23(33)20-13-28-25(31(22(20)32)15-16-5-7-17(27)8-6-16)30-18-9-11-19(12-10-18)37-26-29-14-21(38-26)24(34)36-4-2/h5-14H,3-4,15H2,1-2H3,(H,28,30) AXAACVLJLODQKB-UHFFFAOYSA-N 244308 US9550763, Compound I-056 P2X purinoceptor 3 Homo sapiens 13.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244308 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244308&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 89745288 376222007 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490818 CCc1oc2ccc(cc2c1C)\N=c1/[nH]cc(CN2CCOCC2)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C27H29ClN4O3/c1-3-24-18(2)23-14-22(8-9-25(23)35-24)30-27-29-15-20(17-31-10-12-34-13-11-31)26(33)32(27)16-19-4-6-21(28)7-5-19/h4-9,14-15H,3,10-13,16-17H2,1-2H3,(H,29,30) JAGNIOZJVUBOJM-UHFFFAOYSA-N 244309 US9550763, Compound I-057 P2X purinoceptor 3 Homo sapiens 269 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244309 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244309&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823090 376222008 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490819 CCc1oc2ccc(cc2c1C)\N=c1/[nH]cc(\C=N\OC)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C24H23ClN4O3/c1-4-21-15(2)20-11-19(9-10-22(20)32-21)28-24-26-12-17(13-27-31-3)23(30)29(24)14-16-5-7-18(25)8-6-16/h5-13H,4,14H2,1-3H3,(H,26,28)/b27-13+ OFJGWGZGPOKKEP-UVHMKAGCSA-N 244310 US9550763, Compound I-058 P2X purinoceptor 3 Homo sapiens 223 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244310 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244310&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823091 376222009 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490820 CCOC(=O)c1cnc(Nc2ccc(Oc3ncc(s3)C(O)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H19ClN4O6S/c1-2-34-22(33)18-11-26-23(29(20(18)30)13-14-3-5-15(25)6-4-14)28-16-7-9-17(10-8-16)35-24-27-12-19(36-24)21(31)32/h3-12H,2,13H2,1H3,(H,26,28)(H,31,32) YZTRBNHAHJJQRJ-UHFFFAOYSA-N 244311 US9550763, Compound I-059 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244311 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244311&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118683364 376222010 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490821 CCOC(=O)c1cccc(Oc2ccc(Nc3cc(=O)n(CC)c(=O)n3Cc3ccc(Cl)cc3)cn2)c1 InChI=1S/C27H25ClN4O5/c1-3-31-25(33)15-23(32(27(31)35)17-18-8-10-20(28)11-9-18)30-21-12-13-24(29-16-21)37-22-7-5-6-19(14-22)26(34)36-4-2/h5-16,30H,3-4,17H2,1-2H3 PMTHVBRRHPCCJR-UHFFFAOYSA-N 244312 US9550763, Compound I-060 P2X purinoceptor 3 Homo sapiens 160 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244312 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244312&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823092 376222011 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490822 CCn1c(=O)cc(Nc2ccc(Oc3ccc(cc3)C(=O)OC)nc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H23ClN4O5/c1-3-30-24(32)14-22(31(26(30)34)16-17-4-8-19(27)9-5-17)29-20-10-13-23(28-15-20)36-21-11-6-18(7-12-21)25(33)35-2/h4-15,29H,3,16H2,1-2H3 KIKYPDHNBIXGKB-UHFFFAOYSA-N 244313 US9550763, Compound I-061 P2X purinoceptor 3 Homo sapiens 65.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244313 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244313&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823093 376222012 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490823 CCn1c(=O)cc(Nc2ccc(Oc3cccc(c3)C(O)=O)nc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H21ClN4O5/c1-2-29-23(31)13-21(30(25(29)34)15-16-6-8-18(26)9-7-16)28-19-10-11-22(27-14-19)35-20-5-3-4-17(12-20)24(32)33/h3-14,28H,2,15H2,1H3,(H,32,33) RZWYGYILKGMPES-UHFFFAOYSA-N 244314 US9550763, Compound I-062 P2X purinoceptor 3 Homo sapiens 49.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244314 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244314&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823094 376222013 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490824 CCn1c(=O)cc(Nc2ccc(Oc3ccc(cc3)C(O)=O)nc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H21ClN4O5/c1-2-29-23(31)13-21(30(25(29)34)15-16-3-7-18(26)8-4-16)28-19-9-12-22(27-14-19)35-20-10-5-17(6-11-20)24(32)33/h3-14,28H,2,15H2,1H3,(H,32,33) SCZMSOCAYUAJJH-UHFFFAOYSA-N 244315 US9550763, Compound I-063 P2X purinoceptor 3 Homo sapiens 422 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244315 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244315&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823095 376222014 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490825 Clc1ccc(Cn2c(Nc3ccc(Oc4cccc(n4)C#N)cc3)cc(=O)[nH]c2=O)cc1 InChI=1S/C23H16ClN5O3/c24-16-6-4-15(5-7-16)14-29-20(12-21(30)28-23(29)31)26-17-8-10-19(11-9-17)32-22-3-1-2-18(13-25)27-22/h1-12,26H,14H2,(H,28,30,31) UJHLUGNUTPNZAU-UHFFFAOYSA-N 244316 US9550763, Compound I-064 P2X purinoceptor 3 Homo sapiens 36.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244316 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244316&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 78161129 376222015 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490826 CC(=O)Nc1cnc(Nc2ccc(Oc3ccon3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C22H18ClN5O4/c1-14(29)25-19-12-24-22(28(21(19)30)13-15-2-4-16(23)5-3-15)26-17-6-8-18(9-7-17)32-20-10-11-31-27-20/h2-12H,13H2,1H3,(H,24,26)(H,25,29) KBXHEERZEFDLEZ-UHFFFAOYSA-N 244317 US9550763, Compound I-065 P2X purinoceptor 3 Homo sapiens 99.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244317 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244317&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 71726481 376222016 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490827 NC(=O)c1cccc(Oc2ccc(Nc3cc(=O)[nH]c(=O)n3Cc3ccc(Cl)cc3)cc2)n1 InChI=1S/C23H18ClN5O4/c24-15-6-4-14(5-7-15)13-29-19(12-20(30)28-23(29)32)26-16-8-10-17(11-9-16)33-21-3-1-2-18(27-21)22(25)31/h1-12,26H,13H2,(H2,25,31)(H,28,30,32) FIRJHPSKZVOPGP-UHFFFAOYSA-N 244318 US9550763, Compound I-066 P2X purinoceptor 3 Homo sapiens 81.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244318 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244318&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823096 376222017 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490828 OC(=O)c1cccc(Oc2ccc(Nc3cc(=O)[nH]c(=O)n3Cc3ccc(Cl)cc3)cc2)n1 InChI=1S/C23H17ClN4O5/c24-15-6-4-14(5-7-15)13-28-19(12-20(29)27-23(28)32)25-16-8-10-17(11-9-16)33-21-3-1-2-18(26-21)22(30)31/h1-12,25H,13H2,(H,30,31)(H,27,29,32) ZNQYESGLGDYKGK-UHFFFAOYSA-N 244319 US9550763, Compound I-067 P2X purinoceptor 3 Homo sapiens 34.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244319 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244319&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823097 376222018 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490829 CC(=O)Nc1cnc(Nc2ccc(Oc3cccnn3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H19ClN6O3/c1-15(31)27-20-13-25-23(30(22(20)32)14-16-4-6-17(24)7-5-16)28-18-8-10-19(11-9-18)33-21-3-2-12-26-29-21/h2-13H,14H2,1H3,(H,25,28)(H,27,31) FEMLCXHQCZSMLU-UHFFFAOYSA-N 244320 US9550763, Compound I-069 P2X purinoceptor 3 Homo sapiens 68.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244320 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244320&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118685862 376222019 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490830 CC(=O)Nc1cnc(Nc2ccc(Oc3cccc(F)n3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H19ClFN5O3/c1-15(32)28-20-13-27-24(31(23(20)33)14-16-5-7-17(25)8-6-16)29-18-9-11-19(12-10-18)34-22-4-2-3-21(26)30-22/h2-13H,14H2,1H3,(H,27,29)(H,28,32) BCMGPOFTAOIMJC-UHFFFAOYSA-N 244321 US9550763, Compound I-070 P2X purinoceptor 3 Homo sapiens 28.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244321 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244321&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118685867 376222020 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490831 CCc1oc2ccc(Nc3ncc(NC(C)=O)c(=O)n3Cc3ccc(Cl)cc3)cc2c1C InChI=1S/C24H23ClN4O3/c1-4-21-14(2)19-11-18(9-10-22(19)32-21)28-24-26-12-20(27-15(3)30)23(31)29(24)13-16-5-7-17(25)8-6-16/h5-12H,4,13H2,1-3H3,(H,26,28)(H,27,30) CPPCMYVZKBMXFN-UHFFFAOYSA-N 244322 US9550763, Compound I-071 P2X purinoceptor 3 Homo sapiens 171 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244322 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244322&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 89745148 376222021 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490832 CCOC(=O)Cc1c[nH]\c(=N/c2ccc3oc(CC)c(C)c3c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H26ClN3O4/c1-4-22-16(3)21-13-20(10-11-23(21)34-22)29-26-28-14-18(12-24(31)33-5-2)25(32)30(26)15-17-6-8-19(27)9-7-17/h6-11,13-14H,4-5,12,15H2,1-3H3,(H,28,29) DYQJTCBBHQRINX-UHFFFAOYSA-N 244323 US9550763, Compound I-072 P2X purinoceptor 3 Homo sapiens 228 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244323 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244323&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823098 376222022 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490833 CCc1oc2ccc(cc2c1C)\N=c1/[nH]cc(C(C)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C24H22ClN3O3/c1-4-21-14(2)19-11-18(9-10-22(19)31-21)27-24-26-12-20(15(3)29)23(30)28(24)13-16-5-7-17(25)8-6-16/h5-12H,4,13H2,1-3H3,(H,26,27) TUSAXPVSXXWQHS-UHFFFAOYSA-N 244324 US9550763, Compound I-073 P2X purinoceptor 3 Homo sapiens 140 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244324 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244324&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823099 376222023 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490834 CCc1oc2ccc(cc2c1C)\N=c1/[nH]cc(CC(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C24H22ClN3O4/c1-3-20-14(2)19-11-18(8-9-21(19)32-20)27-24-26-12-16(10-22(29)30)23(31)28(24)13-15-4-6-17(25)7-5-15/h4-9,11-12H,3,10,13H2,1-2H3,(H,26,27)(H,29,30) LXSQYTHGMLBCKC-UHFFFAOYSA-N 244325 US9550763, Compound I-074 P2X purinoceptor 3 Homo sapiens 828 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244325 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244325&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823100 376222024 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490835 CCn1c(=O)cc(Nc2cnc(Oc3cccc(c3)C(N)=O)cn2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H21ClN6O4/c1-2-30-22(32)11-20(31(24(30)34)14-15-6-8-17(25)9-7-15)29-19-12-28-21(13-27-19)35-18-5-3-4-16(10-18)23(26)33/h3-13H,2,14H2,1H3,(H2,26,33)(H,27,29) MOEWQRSJZUFVFI-UHFFFAOYSA-N 244326 US9550763, Compound I-076 P2X purinoceptor 3 Homo sapiens 432 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244326 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244326&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823101 376222025 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490836 CCc1oc2ccc(Nc3ncc(NC(=O)C4CCOCC4)c(=O)n3Cc3ccc(Cl)cc3)cc2c1C InChI=1S/C28H29ClN4O4/c1-3-24-17(2)22-14-21(8-9-25(22)37-24)31-28-30-15-23(32-26(34)19-10-12-36-13-11-19)27(35)33(28)16-18-4-6-20(29)7-5-18/h4-9,14-15,19H,3,10-13,16H2,1-2H3,(H,30,31)(H,32,34) SAMKJBBPVAYUEF-UHFFFAOYSA-N 244327 US9550763, Compound I-077 P2X purinoceptor 3 Homo sapiens 191 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244327 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244327&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 89745365 376222026 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490837 CCc1oc2ccc(Nc3ncc(NC(=O)C4CCOCC4)c(=O)n3Cc3cccc(Cl)c3)cc2c1C InChI=1S/C28H29ClN4O4/c1-3-24-17(2)22-14-21(7-8-25(22)37-24)31-28-30-15-23(32-26(34)19-9-11-36-12-10-19)27(35)33(28)16-18-5-4-6-20(29)13-18/h4-8,13-15,19H,3,9-12,16H2,1-2H3,(H,30,31)(H,32,34) IJYWBQRQBAXDDX-UHFFFAOYSA-N 244328 US9550763, Compound I-078 P2X purinoceptor 3 Homo sapiens 20.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244328 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244328&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 89745360 376222027 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490838 CCc1oc2ccc(Nc3ncc(NC(=O)C4CCOCC4)c(=O)n3Cc3ccc(Cl)c(Cl)c3)cc2c1C InChI=1S/C28H28Cl2N4O4/c1-3-24-16(2)20-13-19(5-7-25(20)38-24)32-28-31-14-23(33-26(35)18-8-10-37-11-9-18)27(36)34(28)15-17-4-6-21(29)22(30)12-17/h4-7,12-14,18H,3,8-11,15H2,1-2H3,(H,31,32)(H,33,35) PKDQRPNJNNASSI-UHFFFAOYSA-N 244329 US9550763, Compound I-079 P2X purinoceptor 3 Homo sapiens 58.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244329 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244329&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 89745359 376222028 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490839 CCc1oc2ccc(Nc3ncc(NC(=O)C4CCOCC4)c(=O)n3CC3CCCCC3)cc2c1C InChI=1S/C28H36N4O4/c1-3-24-18(2)22-15-21(9-10-25(22)36-24)30-28-29-16-23(31-26(33)20-11-13-35-14-12-20)27(34)32(28)17-19-7-5-4-6-8-19/h9-10,15-16,19-20H,3-8,11-14,17H2,1-2H3,(H,29,30)(H,31,33) RGZXHUVXKCGCHY-UHFFFAOYSA-N 244330 US9550763, Compound I-080 P2X purinoceptor 3 Homo sapiens 20.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244330 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244330&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118685860 376222029 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490840 CCc1oc2ccc(Nc3ncc(NC(=O)C4CCOCC4)c(=O)n3C[C@H]3CC[C@H](C)CC3)cc2c1C InChI=1S/C29H38N4O4/c1-4-25-19(3)23-15-22(9-10-26(23)37-25)31-29-30-16-24(32-27(34)21-11-13-36-14-12-21)28(35)33(29)17-20-7-5-18(2)6-8-20/h9-10,15-16,18,20-21H,4-8,11-14,17H2,1-3H3,(H,30,31)(H,32,34)/t18-,20- ZVJPWSZHPXRDPT-KESTWPANSA-N 244331 US9550763, Compound I-082 P2X purinoceptor 3 Homo sapiens 9.00 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244331 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244331&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 89745382 376222030 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490841 CCn1c(=O)cc(Nc2cnc(Oc3cccc(c3)C(O)=O)cn2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H20ClN5O5/c1-2-29-22(31)11-20(30(24(29)34)14-15-6-8-17(25)9-7-15)28-19-12-27-21(13-26-19)35-18-5-3-4-16(10-18)23(32)33/h3-13H,2,14H2,1H3,(H,26,28)(H,32,33) LSGUVMKBFQHLPM-UHFFFAOYSA-N 244332 US9550763, Compound I-083 P2X purinoceptor 3 Homo sapiens 168 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244332 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244332&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823102 376222031 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490842 CCc1oc2ccc(cc2c1C)\N=c1/[nH]cc(CC(N)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C24H23ClN4O3/c1-3-20-14(2)19-11-18(8-9-21(19)32-20)28-24-27-12-16(10-22(26)30)23(31)29(24)13-15-4-6-17(25)7-5-15/h4-9,11-12H,3,10,13H2,1-2H3,(H2,26,30)(H,27,28) JICNGQHPLTUHJX-UHFFFAOYSA-N 244333 US9550763, Compound I-084 P2X purinoceptor 3 Homo sapiens 103 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244333 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244333&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823103 376222032 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490843 Clc1ccc(Cn2c(Nc3ccc(Oc4ccon4)cc3)ncc(NC(=O)C3CCOCC3)c2=O)cc1 InChI=1S/C26H24ClN5O5/c27-19-3-1-17(2-4-19)16-32-25(34)22(30-24(33)18-9-12-35-13-10-18)15-28-26(32)29-20-5-7-21(8-6-20)37-23-11-14-36-31-23/h1-8,11,14-15,18H,9-10,12-13,16H2,(H,28,29)(H,30,33) SRJDSMMPYSWWMN-UHFFFAOYSA-N 244334 US9550763, Compound I-086 P2X purinoceptor 3 Homo sapiens 2.00 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244334 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244334&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 89745436 376222033 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490844 CCc1c[nH]\c(=N/c2ccc(Oc3ncc(s3)C(O)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H19ClN4O4S/c1-2-15-11-25-22(28(20(15)29)13-14-3-5-16(24)6-4-14)27-17-7-9-18(10-8-17)32-23-26-12-19(33-23)21(30)31/h3-12H,2,13H2,1H3,(H,25,27)(H,30,31) RNCPYIVFMFYFLS-UHFFFAOYSA-N 244335 US9550763, Compound I-087 P2X purinoceptor 3 Homo sapiens 29.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244335 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244335&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823104 376222034 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490845 CCC(=O)Nc1c[nH]\c(=N/c2ccc(Oc3ccon3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H20ClN5O4/c1-2-20(30)27-19-13-25-23(29(22(19)31)14-15-3-5-16(24)6-4-15)26-17-7-9-18(10-8-17)33-21-11-12-32-28-21/h3-13H,2,14H2,1H3,(H,25,26)(H,27,30) XEVHSWMPUQBKNA-UHFFFAOYSA-N 244336 US9550763, Compound I-088 P2X purinoceptor 3 Homo sapiens 49.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244336 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244336&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823105 376222035 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490846 CCC(=O)Nc1c[nH]\c(=N/c2ccc(Oc3ccc(CO)nn3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H23ClN6O4/c1-2-22(34)29-21-13-27-25(32(24(21)35)14-16-3-5-17(26)6-4-16)28-18-7-10-20(11-8-18)36-23-12-9-19(15-33)30-31-23/h3-13,33H,2,14-15H2,1H3,(H,27,28)(H,29,34) UGTWJEGCNVMJJJ-UHFFFAOYSA-N 244337 US9550763, Compound I-089 P2X purinoceptor 3 Homo sapiens 17.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244337 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244337&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823106 376222036 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490847 CCC(=O)Nc1c[nH]\c(=N/c2ccc(Oc3cccc(F)n3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H21ClFN5O3/c1-2-22(33)30-20-14-28-25(32(24(20)34)15-16-6-8-17(26)9-7-16)29-18-10-12-19(13-11-18)35-23-5-3-4-21(27)31-23/h3-14H,2,15H2,1H3,(H,28,29)(H,30,33) PCPCGLFNYGCHDP-UHFFFAOYSA-N 244338 US9550763, Compound I-090 P2X purinoceptor 3 Homo sapiens 11.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244338 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244338&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823107 376222037 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490848 CCC(=O)Nc1c[nH]\c(=N/c2ccc(Oc3ccc(nc3)C(=O)OC)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C27H24ClN5O5/c1-3-24(34)32-23-15-30-27(33(25(23)35)16-17-4-6-18(28)7-5-17)31-19-8-10-20(11-9-19)38-21-12-13-22(29-14-21)26(36)37-2/h4-15H,3,16H2,1-2H3,(H,30,31)(H,32,34) ZCCBOXNZDPPXEN-UHFFFAOYSA-N 244339 US9550763, Compound I-091 P2X purinoceptor 3 Homo sapiens 3.00 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244339 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244339&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823108 376222038 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490849 CCC(=O)Nc1c[nH]\c(=N/c2ccc(Oc3ccc(nc3)C(O)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H22ClN5O5/c1-2-23(33)31-22-14-29-26(32(24(22)34)15-16-3-5-17(27)6-4-16)30-18-7-9-19(10-8-18)37-20-11-12-21(25(35)36)28-13-20/h3-14H,2,15H2,1H3,(H,29,30)(H,31,33)(H,35,36) CZJKFLCHCPLMCJ-UHFFFAOYSA-N 244340 US9550763, Compound I-092 P2X purinoceptor 3 Homo sapiens 19.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244340 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244340&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823109 376222039 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490850 CCC(=O)Nc1c[nH]\c(=N/c2ccc(Oc3cccc(n3)C(N)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H23ClN6O4/c1-2-22(34)31-21-14-29-26(33(25(21)36)15-16-6-8-17(27)9-7-16)30-18-10-12-19(13-11-18)37-23-5-3-4-20(32-23)24(28)35/h3-14H,2,15H2,1H3,(H2,28,35)(H,29,30)(H,31,34) MLHCQFSYRYKOKW-UHFFFAOYSA-N 244341 US9550763, Compound I-093 P2X purinoceptor 3 Homo sapiens 9.00 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244341 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244341&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823110 376222040 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490851 CCC(=O)Nc1c[nH]\c(=N/c2ccc(Oc3cnc(cn3)C(O)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H21ClN6O5/c1-2-21(33)31-19-11-29-25(32(23(19)34)14-15-3-5-16(26)6-4-15)30-17-7-9-18(10-8-17)37-22-13-27-20(12-28-22)24(35)36/h3-13H,2,14H2,1H3,(H,29,30)(H,31,33)(H,35,36) LROHUQJTXVCKOD-UHFFFAOYSA-N 244342 US9550763, Compound I-094 P2X purinoceptor 3 Homo sapiens 10.00 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244342 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244342&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823111 376222041 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490852 CCC(=O)Nc1c[nH]\c(=N/c2ccc(Oc3ccc(nc3)C(N)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H23ClN6O4/c1-2-23(34)32-22-14-30-26(33(25(22)36)15-16-3-5-17(27)6-4-16)31-18-7-9-19(10-8-18)37-20-11-12-21(24(28)35)29-13-20/h3-14H,2,15H2,1H3,(H2,28,35)(H,30,31)(H,32,34) UHFKYZRDYXHNLQ-UHFFFAOYSA-N 244343 US9550763, Compound I-095 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244343 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244343&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823112 376222042 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490853 CCOC(=O)c1c[nH]\c(=N/c2ccc(Oc3ccon3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H19ClN4O5/c1-2-31-22(30)19-13-25-23(28(21(19)29)14-15-3-5-16(24)6-4-15)26-17-7-9-18(10-8-17)33-20-11-12-32-27-20/h3-13H,2,14H2,1H3,(H,25,26) XBWCHKLRYKYCKO-UHFFFAOYSA-N 244344 US9550763, Compound I-096 P2X purinoceptor 3 Homo sapiens 64.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244344 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244344&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823113 376222043 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490854 CCC(=O)Nc1c[nH]\c(=N/c2ccc(Oc3cnc(cn3)C(N)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H22ClN7O4/c1-2-21(34)32-20-12-30-25(33(24(20)36)14-15-3-5-16(26)6-4-15)31-17-7-9-18(10-8-17)37-22-13-28-19(11-29-22)23(27)35/h3-13H,2,14H2,1H3,(H2,27,35)(H,30,31)(H,32,34) OIOKKHUAXLLAPB-UHFFFAOYSA-N 244345 US9550763, Compound I-097 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244345 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244345&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823114 376222044 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490855 CCC(=O)Nc1c[nH]\c(=N/c2ccc(Oc3ccnc(c3)C(=O)OC)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C27H24ClN5O5/c1-3-24(34)32-23-15-30-27(33(25(23)35)16-17-4-6-18(28)7-5-17)31-19-8-10-20(11-9-19)38-21-12-13-29-22(14-21)26(36)37-2/h4-15H,3,16H2,1-2H3,(H,30,31)(H,32,34) CJYDYMDSAPSRBC-UHFFFAOYSA-N 244346 US9550763, Compound I-098 P2X purinoceptor 3 Homo sapiens 11.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244346 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244346&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823115 376222045 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490856 OC(=O)c1c[nH]\c(=N/c2ccc(Oc3ccon3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C21H15ClN4O5/c22-14-3-1-13(2-4-14)12-26-19(27)17(20(28)29)11-23-21(26)24-15-5-7-16(8-6-15)31-18-9-10-30-25-18/h1-11H,12H2,(H,23,24)(H,28,29) POXIVQAKVMLNQN-UHFFFAOYSA-N 244347 US9550763, Compound I-099 P2X purinoceptor 3 Homo sapiens 534 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244347 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244347&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823116 376222046 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490857 NC(=O)c1c[nH]\c(=N/c2ccc(Oc3ccon3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C21H16ClN5O4/c22-14-3-1-13(2-4-14)12-27-20(29)17(19(23)28)11-24-21(27)25-15-5-7-16(8-6-15)31-18-9-10-30-26-18/h1-11H,12H2,(H2,23,28)(H,24,25) GCYRKAHTEGJIEK-UHFFFAOYSA-N 244348 US9550763, Compound I-100 P2X purinoceptor 3 Homo sapiens 32.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244348 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244348&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823117 376222047 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490858 OCCNC(=O)c1c[nH]\c(=N/c2ccc(Oc3ccon3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H20ClN5O5/c24-16-3-1-15(2-4-16)14-29-22(32)19(21(31)25-10-11-30)13-26-23(29)27-17-5-7-18(8-6-17)34-20-9-12-33-28-20/h1-9,12-13,30H,10-11,14H2,(H,25,31)(H,26,27) MJZVJPDRVRTPME-UHFFFAOYSA-N 244349 US9550763, Compound I-101 P2X purinoceptor 3 Homo sapiens 71.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244349 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244349&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823118 376222048 C04080 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490859 CCc1oc2ccc(cc2c1C)\N=c1/[nH]cc(CC(C)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C25H24ClN3O3/c1-4-22-16(3)21-12-20(9-10-23(21)32-22)28-25-27-13-18(11-15(2)30)24(31)29(25)14-17-5-7-19(26)8-6-17/h5-10,12-13H,4,11,14H2,1-3H3,(H,27,28) NZMCXNADWAXOCN-UHFFFAOYSA-N 244350 US9550763, Compound I-102 P2X purinoceptor 3 Homo sapiens 267 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244350 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244350&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823119 376222049 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490860 CCc1oc2ccc(cc2c1C)\N=c1/[nH]cc(CC(C)(C)O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C26H28ClN3O3/c1-5-22-16(2)21-12-20(10-11-23(21)33-22)29-25-28-14-18(13-26(3,4)32)24(31)30(25)15-17-6-8-19(27)9-7-17/h6-12,14,32H,5,13,15H2,1-4H3,(H,28,29) CPGZVASWGDXMBC-UHFFFAOYSA-N 244351 US9550763, Compound I-103 P2X purinoceptor 3 Homo sapiens 144 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244351 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244351&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823120 376222050 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490861 CCC(=O)Nc1c[nH]\c(=N/c2ccc(Oc3cccc(n3)C(O)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H22ClN5O5/c1-2-22(33)30-21-14-28-26(32(24(21)34)15-16-6-8-17(27)9-7-16)29-18-10-12-19(13-11-18)37-23-5-3-4-20(31-23)25(35)36/h3-14H,2,15H2,1H3,(H,28,29)(H,30,33)(H,35,36) HCGSNIFOOWSAJP-UHFFFAOYSA-N 244352 US9550763, Compound I-104 P2X purinoceptor 3 Homo sapiens 3.00 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244352 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244352&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823121 376222051 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490862 CCC(=O)Nc1c[nH]\c(=N/c2ccc(Oc3ccnc(c3)C(O)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H22ClN5O5/c1-2-23(33)31-22-14-29-26(32(24(22)34)15-16-3-5-17(27)6-4-16)30-18-7-9-19(10-8-18)37-20-11-12-28-21(13-20)25(35)36/h3-14H,2,15H2,1H3,(H,29,30)(H,31,33)(H,35,36) MLYWQMDHPGORFR-UHFFFAOYSA-N 244353 US9550763, Compound I-105 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244353 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244353&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823122 376222052 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490863 CCC(=O)Nc1c[nH]\c(=N/c2ccc(Oc3ccnc(c3)C(N)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H23ClN6O4/c1-2-23(34)32-22-14-30-26(33(25(22)36)15-16-3-5-17(27)6-4-16)31-18-7-9-19(10-8-18)37-20-11-12-29-21(13-20)24(28)35/h3-14H,2,15H2,1H3,(H2,28,35)(H,30,31)(H,32,34) HMMCMXDGSWZKRO-UHFFFAOYSA-N 244354 US9550763, Compound I-106 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244354 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244354&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823123 376222053 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490864 CCOC(=O)c1c[nH]\c(=N/c2ccc(Oc3ncccc3F)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H20ClFN4O4/c1-2-34-24(33)20-14-29-25(31(23(20)32)15-16-5-7-17(26)8-6-16)30-18-9-11-19(12-10-18)35-22-21(27)4-3-13-28-22/h3-14H,2,15H2,1H3,(H,29,30) KUFPHDCGHHKAEK-UHFFFAOYSA-N 244355 US9550763, Compound I-107 P2X purinoceptor 3 Homo sapiens 29.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244355 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244355&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823124 376222054 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490865 OC(=O)c1c[nH]\c(=N/c2ccc(Oc3ncccc3F)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H16ClFN4O4/c24-15-5-3-14(4-6-15)13-29-21(30)18(22(31)32)12-27-23(29)28-16-7-9-17(10-8-16)33-20-19(25)2-1-11-26-20/h1-12H,13H2,(H,27,28)(H,31,32) ZHGBFNADGHVUEO-UHFFFAOYSA-N 244356 US9550763, Compound I-108 P2X purinoceptor 3 Homo sapiens 440 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244356 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244356&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823125 376222055 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490866 CN(C(=O)C1CCOCC1)c1c[nH]\c(=N/c2ccc(Oc3ccon3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C27H26ClN5O5/c1-32(25(34)19-10-13-36-14-11-19)23-16-29-27(33(26(23)35)17-18-2-4-20(28)5-3-18)30-21-6-8-22(9-7-21)38-24-12-15-37-31-24/h2-9,12,15-16,19H,10-11,13-14,17H2,1H3,(H,29,30) ADRWFGBOPFLVAG-UHFFFAOYSA-N 244357 US9550763, Compound I-109 P2X purinoceptor 3 Homo sapiens 34.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244357 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244357&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823126 376222056 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490867 NC(=O)c1c[nH]\c(=N/c2ccc(Oc3ncccc3F)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H17ClFN5O3/c24-15-5-3-14(4-6-15)13-30-22(32)18(20(26)31)12-28-23(30)29-16-7-9-17(10-8-16)33-21-19(25)2-1-11-27-21/h1-12H,13H2,(H2,26,31)(H,28,29) UABDWSUGKWTFHH-UHFFFAOYSA-N 244358 US9550763, Compound I-110 P2X purinoceptor 3 Homo sapiens 27.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244358 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244358&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823127 376222057 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490868 OCCNC(=O)c1c[nH]\c(=N/c2ccc(Oc3ncccc3F)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H21ClFN5O4/c26-17-5-3-16(4-6-17)15-32-24(35)20(22(34)28-12-13-33)14-30-25(32)31-18-7-9-19(10-8-18)36-23-21(27)2-1-11-29-23/h1-11,14,33H,12-13,15H2,(H,28,34)(H,30,31) TVWMXBTVEIEKSI-UHFFFAOYSA-N 244359 US9550763, Compound I-111 P2X purinoceptor 3 Homo sapiens 22.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244359 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244359&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823128 376222058 C04080 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490869 CCOC(=O)c1c[nH]\c(=N/c2ccc(Oc3cccc(F)n3)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H22ClFN4O4/c1-3-35-25(34)20-14-29-26(32(24(20)33)15-17-7-9-18(27)10-8-17)30-19-11-12-21(16(2)13-19)36-23-6-4-5-22(28)31-23/h4-14H,3,15H2,1-2H3,(H,29,30) WWWXVSIURQLDTI-UHFFFAOYSA-N 244360 US9550763, Compound I-112 P2X purinoceptor 3 Homo sapiens 24.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244360 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244360&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823129 376222059 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490870 COC(=O)[C@@H](C)Cn1c(=O)cc(Nc2ccc(Oc3ccccc3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C28H26ClN3O5/c1-19(27(34)36-2)17-32-26(33)16-25(31(28(32)35)18-20-8-10-21(29)11-9-20)30-22-12-14-24(15-13-22)37-23-6-4-3-5-7-23/h3-16,19,30H,17-18H2,1-2H3/t19-/m0/s1 NQLSXZMAHANSNC-IBGZPJMESA-N 244361 US9550763, Compound I-113 P2X purinoceptor 3 Homo sapiens 187 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244361 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244361&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823130 376222060 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490871 COC(=O)[C@@H](C)Cn1c(=O)cc(Nc2ccc(Oc3ccon3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H23ClN4O6/c1-16(24(32)34-2)14-30-23(31)13-21(29(25(30)33)15-17-3-5-18(26)6-4-17)27-19-7-9-20(10-8-19)36-22-11-12-35-28-22/h3-13,16,27H,14-15H2,1-2H3/t16-/m0/s1 OELRVUYLCIVHHH-INIZCTEOSA-N 244362 US9550763, Compound I-114 P2X purinoceptor 3 Homo sapiens 17.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244362 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244362&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823131 376222061 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490872 COC(=O)[C@@H](C)Cn1c(=O)cc(Nc2ccc(Oc3ncccc3F)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C27H24ClFN4O5/c1-17(26(35)37-2)15-33-24(34)14-23(32(27(33)36)16-18-5-7-19(28)8-6-18)31-20-9-11-21(12-10-20)38-25-22(29)4-3-13-30-25/h3-14,17,31H,15-16H2,1-2H3/t17-/m0/s1 UNBMNXFNENXJFZ-KRWDZBQOSA-N 244363 US9550763, Compound I-115 P2X purinoceptor 3 Homo sapiens 9.00 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244363 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244363&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823132 376222062 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490873 COC(=O)[C@@H](C)Cn1c(=O)cc(Nc2ccc(Oc3cccc(F)n3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C27H24ClFN4O5/c1-17(26(35)37-2)15-33-25(34)14-23(32(27(33)36)16-18-6-8-19(28)9-7-18)30-20-10-12-21(13-11-20)38-24-5-3-4-22(29)31-24/h3-14,17,30H,15-16H2,1-2H3/t17-/m0/s1 VJGDXOSUOZCVIZ-KRWDZBQOSA-N 244364 US9550763, Compound I-116 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244364 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244364&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823133 376222063 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490874 C[C@@H](Cn1c(=O)cc(Nc2ccc(Oc3ccccc3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O InChI=1S/C27H24ClN3O5/c1-18(26(33)34)16-31-25(32)15-24(30(27(31)35)17-19-7-9-20(28)10-8-19)29-21-11-13-23(14-12-21)36-22-5-3-2-4-6-22/h2-15,18,29H,16-17H2,1H3,(H,33,34)/t18-/m0/s1 JTQUVGUZJAXMNZ-SFHVURJKSA-N 244365 US9550763, Compound I-117 P2X purinoceptor 3 Homo sapiens 26.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244365 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244365&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823134 376222064 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490875 CCC(=O)Nc1c[nH]\c(=N/c2ccc(Oc3ccc(CO)nc3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H24ClN5O4/c1-2-24(34)31-23-14-29-26(32(25(23)35)15-17-3-5-18(27)6-4-17)30-19-7-10-21(11-8-19)36-22-12-9-20(16-33)28-13-22/h3-14,33H,2,15-16H2,1H3,(H,29,30)(H,31,34) MRHLITFBGGFWMO-UHFFFAOYSA-N 244366 US9550763, Compound I-118 P2X purinoceptor 3 Homo sapiens 17.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244366 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244366&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823135 376222065 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490876 C[C@@H](Cn1c(=O)cc(Nc2ccc(Oc3ncccc3F)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O InChI=1S/C26H22ClFN4O5/c1-16(25(34)35)14-32-23(33)13-22(31(26(32)36)15-17-4-6-18(27)7-5-17)30-19-8-10-20(11-9-19)37-24-21(28)3-2-12-29-24/h2-13,16,30H,14-15H2,1H3,(H,34,35)/t16-/m0/s1 ADBNZAWEDDYRSM-INIZCTEOSA-N 244367 US9550763, Compound I-119 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244367 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244367&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823136 376222066 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490877 C[C@@H](Cn1c(=O)cc(Nc2ccc(Oc3cccc(F)n3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O InChI=1S/C26H22ClFN4O5/c1-16(25(34)35)14-32-24(33)13-22(31(26(32)36)15-17-5-7-18(27)8-6-17)29-19-9-11-20(12-10-19)37-23-4-2-3-21(28)30-23/h2-13,16,29H,14-15H2,1H3,(H,34,35)/t16-/m0/s1 WRWJNHANINETGS-INIZCTEOSA-N 244368 US9550763, Compound I-120 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244368 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244368&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823137 376222067 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490878 C[C@@H](Cn1c(=O)cc(Nc2ccc(Oc3ccon3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O InChI=1S/C24H21ClN4O6/c1-15(23(31)32)13-29-22(30)12-20(28(24(29)33)14-16-2-4-17(25)5-3-16)26-18-6-8-19(9-7-18)35-21-10-11-34-27-21/h2-12,15,26H,13-14H2,1H3,(H,31,32)/t15-/m0/s1 IZWOTGFEEKJFOP-HNNXBMFYSA-N 244369 US9550763, Compound I-121 P2X purinoceptor 3 Homo sapiens 26.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244369 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244369&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823138 376222068 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490879 COC(=O)[C@@H](C)Cn1c(=O)cc(Nc2ccc(Oc3cccc(n3)C#N)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C28H23ClFN5O5/c1-17(27(37)39-2)15-35-26(36)13-24(34(28(35)38)16-18-6-8-19(29)9-7-18)32-20-10-11-23(22(30)12-20)40-25-5-3-4-21(14-31)33-25/h3-13,17,32H,15-16H2,1-2H3/t17-/m0/s1 CSRCTYAFSCAQOO-KRWDZBQOSA-N 244370 US9550763, Compound I-122 P2X purinoceptor 3 Homo sapiens 3.00 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244370 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244370&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823139 376222069 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490880 Fc1ccc(Cn2c(=O)c(NC(=O)C3CCOCC3)c[nH]\c2=N/c2ccc(Oc3ccon3)cc2)cc1 InChI=1S/C26H24FN5O5/c27-19-3-1-17(2-4-19)16-32-25(34)22(30-24(33)18-9-12-35-13-10-18)15-28-26(32)29-20-5-7-21(8-6-20)37-23-11-14-36-31-23/h1-8,11,14-15,18H,9-10,12-13,16H2,(H,28,29)(H,30,33) JWIMJJFXWWWXFJ-UHFFFAOYSA-N 244371 US9550763, Compound I-123 P2X purinoceptor 3 Homo sapiens 24.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244371 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244371&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823140 376222070 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490881 CCn1c(=O)cc(Nc2ccc(Oc3cccc(n3)C#N)cn2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H19ClN6O3/c1-2-30-23(32)12-21(31(24(30)33)15-16-6-8-17(25)9-7-16)29-20-11-10-19(14-27-20)34-22-5-3-4-18(13-26)28-22/h3-12,14H,2,15H2,1H3,(H,27,29) AWRSUIYRRUKSLH-UHFFFAOYSA-N 244372 US9550763, Compound I-124 P2X purinoceptor 3 Homo sapiens 19.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244372 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244372&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823141 376222071 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490882 CCn1c(=O)cc(Nc2ccc(Oc3cccc(n3)C(O)=O)cn2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H20ClN5O5/c1-2-29-22(31)12-20(30(24(29)34)14-15-6-8-16(25)9-7-15)28-19-11-10-17(13-26-19)35-21-5-3-4-18(27-21)23(32)33/h3-13H,2,14H2,1H3,(H,26,28)(H,32,33) PAUPFRGTXYPTLH-UHFFFAOYSA-N 244373 US9550763, Compound I-125 P2X purinoceptor 3 Homo sapiens 23.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244373 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244373&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823142 376222072 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490883 C[C@@H](Cn1c(=O)cc(Nc2ccc(Oc3cccc(n3)C(N)=O)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O InChI=1S/C27H23ClFN5O6/c1-15(26(37)38)13-34-24(35)12-22(33(27(34)39)14-16-5-7-17(28)8-6-16)31-18-9-10-21(19(29)11-18)40-23-4-2-3-20(32-23)25(30)36/h2-12,15,31H,13-14H2,1H3,(H2,30,36)(H,37,38)/t15-/m0/s1 VLROVDRVUJRTRQ-HNNXBMFYSA-N 244374 US9550763, Compound I-126 P2X purinoceptor 3 Homo sapiens 3.00 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244374 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244374&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823143 376222073 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490884 C[C@@H](Cn1c(=O)cc(Nc2ccc(Oc3cccc(n3)C#N)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O InChI=1S/C27H21ClFN5O5/c1-16(26(36)37)14-34-25(35)12-23(33(27(34)38)15-17-5-7-18(28)8-6-17)31-19-9-10-22(21(29)11-19)39-24-4-2-3-20(13-30)32-24/h2-12,16,31H,14-15H2,1H3,(H,36,37)/t16-/m0/s1 IQDDWAADKRIYMJ-INIZCTEOSA-N 244375 US9550763, Compound I-127 P2X purinoceptor 3 Homo sapiens 3.00 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244375 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244375&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823144 376222074 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490885 CCOC(=O)c1c[nH]\c(=N/c2ccc(Oc3ccc(F)cn3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H20ClFN4O4/c1-2-34-24(33)21-14-29-25(31(23(21)32)15-16-3-5-17(26)6-4-16)30-19-8-10-20(11-9-19)35-22-12-7-18(27)13-28-22/h3-14H,2,15H2,1H3,(H,29,30) SGGLIXKPRUBVNH-UHFFFAOYSA-N 244376 US9550763, Compound I-128 P2X purinoceptor 3 Homo sapiens 35.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244376 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244376&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823145 376222075 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490886 CCc1c[nH]\c(=N/c2ccc(Oc3cccc(n3)C#N)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H20ClN5O2/c1-2-18-15-28-25(31(24(18)32)16-17-6-8-19(26)9-7-17)30-20-10-12-22(13-11-20)33-23-5-3-4-21(14-27)29-23/h3-13,15H,2,16H2,1H3,(H,28,30) PRBJJVFTUOBHST-UHFFFAOYSA-N 244377 US9550763, Compound I-129 P2X purinoceptor 3 Homo sapiens 61.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244377 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244377&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823146 376222076 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490887 CCc1c[nH]\c(=N/c2ccc(Oc3cccc(n3)C#N)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H22ClN5O2/c1-3-19-15-29-26(32(25(19)33)16-18-7-9-20(27)10-8-18)31-21-11-12-23(17(2)13-21)34-24-6-4-5-22(14-28)30-24/h4-13,15H,3,16H2,1-2H3,(H,29,31) BGGHBICMNLACSN-UHFFFAOYSA-N 244378 US9550763, Compound I-130 P2X purinoceptor 3 Homo sapiens 32.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244378 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244378&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823147 376222077 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490888 Clc1ccc(Cn2c(Nc3ccc(Oc4nccs4)cc3)ncc(NC(=O)C3CCOCC3)c2=O)cc1 InChI=1S/C26H24ClN5O4S/c27-19-3-1-17(2-4-19)16-32-24(34)22(31-23(33)18-9-12-35-13-10-18)15-29-25(32)30-20-5-7-21(8-6-20)36-26-28-11-14-37-26/h1-8,11,14-15,18H,9-10,12-13,16H2,(H,29,30)(H,31,33) CJNKGLDZYNTFEG-UHFFFAOYSA-N 244379 US9550763, Compound I-131 P2X purinoceptor 3 Homo sapiens 2.00 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244379 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244379&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 89745188 376222078 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490889 Fc1cccnc1Oc1ccc(Nc2ncc(NC(=O)C3CCOCC3)c(=O)n2Cc2ccc(Cl)cc2)cc1 InChI=1S/C28H25ClFN5O4/c29-20-5-3-18(4-6-20)17-35-27(37)24(34-25(36)19-11-14-38-15-12-19)16-32-28(35)33-21-7-9-22(10-8-21)39-26-23(30)2-1-13-31-26/h1-10,13,16,19H,11-12,14-15,17H2,(H,32,33)(H,34,36) JDMQNJTZKLALQT-UHFFFAOYSA-N 244380 US9550763, Compound I-132 P2X purinoceptor 3 Homo sapiens 2.00 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244380 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244380&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 89745409 376222079 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490890 Fc1ccc(Oc2ccc(Nc3ncc(NC(=O)C4CCOCC4)c(=O)n3Cc3ccc(Cl)cc3)cc2)nc1 InChI=1S/C28H25ClFN5O4/c29-20-3-1-18(2-4-20)17-35-27(37)24(34-26(36)19-11-13-38-14-12-19)16-32-28(35)33-22-6-8-23(9-7-22)39-25-10-5-21(30)15-31-25/h1-10,15-16,19H,11-14,17H2,(H,32,33)(H,34,36) UVHLUWRFYQNJLY-UHFFFAOYSA-N 244381 US9550763, Compound I-133 P2X purinoceptor 3 Homo sapiens 1.000 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244381 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244381&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 89745403 376222080 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490891 Fc1cccc(Oc2ccc(Nc3ncc(NC(=O)C4CCOCC4)c(=O)n3Cc3ccc(Cl)cc3)cc2)n1 InChI=1S/C28H25ClFN5O4/c29-20-6-4-18(5-7-20)17-35-27(37)23(33-26(36)19-12-14-38-15-13-19)16-31-28(35)32-21-8-10-22(11-9-21)39-25-3-1-2-24(30)34-25/h1-11,16,19H,12-15,17H2,(H,31,32)(H,33,36) PNOYIRVQDLBXFW-UHFFFAOYSA-N 244382 US9550763, Compound I-134 P2X purinoceptor 3 Homo sapiens 2.00 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244382 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244382&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 89745406 376222081 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490892 Cc1cc(Nc2ncc(NC(=O)C3CCOCC3)c(=O)n2Cc2ccc(Cl)cc2)ccc1Oc1cccc(F)n1 InChI=1S/C29H27ClFN5O4/c1-18-15-22(9-10-24(18)40-26-4-2-3-25(31)35-26)33-29-32-16-23(34-27(37)20-11-13-39-14-12-20)28(38)36(29)17-19-5-7-21(30)8-6-19/h2-10,15-16,20H,11-14,17H2,1H3,(H,32,33)(H,34,37) STAOOLOPSQLOEV-UHFFFAOYSA-N 244383 US9550763, Compound I-135 P2X purinoceptor 3 Homo sapiens 2.00 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244383 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244383&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118686115 376222082 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490893 Cc1cncc(Oc2ccc(Nc3ncc(NC(=O)C4CCOCC4)c(=O)n3Cc3ccc(Cl)cc3)cc2)n1 InChI=1S/C28H27ClN6O4/c1-18-14-30-16-25(32-18)39-23-8-6-22(7-9-23)33-28-31-15-24(34-26(36)20-10-12-38-13-11-20)27(37)35(28)17-19-2-4-21(29)5-3-19/h2-9,14-16,20H,10-13,17H2,1H3,(H,31,33)(H,34,36) ZRQUORVERJWXDV-UHFFFAOYSA-N 244384 US9550763, Compound I-136 P2X purinoceptor 3 Homo sapiens 2.00 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244384 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244384&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 71726613 376222083 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490894 Cc1ccc(Oc2ccc(Nc3ncc(NC(=O)C4CCOCC4)c(=O)n3Cc3ccc(Cl)cc3)cc2)nn1 InChI=1S/C28H27ClN6O4/c1-18-2-11-25(34-33-18)39-23-9-7-22(8-10-23)31-28-30-16-24(32-26(36)20-12-14-38-15-13-20)27(37)35(28)17-19-3-5-21(29)6-4-19/h2-11,16,20H,12-15,17H2,1H3,(H,30,31)(H,32,36) NPYMRBJJKMZKTN-UHFFFAOYSA-N 244385 US9550763, Compound I-137 P2X purinoceptor 3 Homo sapiens 1.000 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244385 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244385&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118686061 376222084 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490895 CCC(=O)Nc1c[nH]\c(=N/c2ccc(Oc3cnc(cn3)C#N)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H20ClN7O3/c1-2-22(34)32-21-13-30-25(33(24(21)35)15-16-3-5-17(26)6-4-16)31-18-7-9-20(10-8-18)36-23-14-28-19(11-27)12-29-23/h3-10,12-14H,2,15H2,1H3,(H,30,31)(H,32,34) LASDMRXPIGTQGN-UHFFFAOYSA-N 244386 US9550763, Compound I-138 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244386 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244386&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823148 376222085 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490896 Cc1cc(ccc1Oc1cccc(F)n1)\N=c1/[nH]cc(C(N)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C24H19ClFN5O3/c1-14-11-17(9-10-19(14)34-21-4-2-3-20(26)30-21)29-24-28-12-18(22(27)32)23(33)31(24)13-15-5-7-16(25)8-6-15/h2-12H,13H2,1H3,(H2,27,32)(H,28,29) OEOASNCOJQFISI-UHFFFAOYSA-N 244387 US9550763, Compound I-139 P2X purinoceptor 3 Homo sapiens 16.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244387 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244387&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823149 376222086 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490897 COc1cccc(Oc2ccc(cc2C)\N=c2/[nH]cc(C(N)=O)c(=O)n2Cc2ccc(Cl)cc2)n1 InChI=1S/C25H22ClN5O4/c1-15-12-18(10-11-20(15)35-22-5-3-4-21(30-22)34-2)29-25-28-13-19(23(27)32)24(33)31(25)14-16-6-8-17(26)9-7-16/h3-13H,14H2,1-2H3,(H2,27,32)(H,28,29) IXDJVXWVLFEKRN-UHFFFAOYSA-N 244388 US9550763, Compound I-140 P2X purinoceptor 3 Homo sapiens 99.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244388 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244388&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823150 376222087 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490898 OC(=O)c1c[nH]\c(=N/c2ccc(Oc3ccc(F)cn3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H16ClFN4O4/c24-15-3-1-14(2-4-15)13-29-21(30)19(22(31)32)12-27-23(29)28-17-6-8-18(9-7-17)33-20-10-5-16(25)11-26-20/h1-12H,13H2,(H,27,28)(H,31,32) CAXMBMBZKKQNIC-UHFFFAOYSA-N 244389 US9550763, Compound I-141 P2X purinoceptor 3 Homo sapiens 467 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244389 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244389&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823151 376222088 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490899 NC(=O)c1c[nH]\c(=N/c2ccc(Oc3ccc(F)cn3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H17ClFN5O3/c24-15-3-1-14(2-4-15)13-30-22(32)19(21(26)31)12-28-23(30)29-17-6-8-18(9-7-17)33-20-10-5-16(25)11-27-20/h1-12H,13H2,(H2,26,31)(H,28,29) CHNSQFXWBLPVAB-UHFFFAOYSA-N 244390 US9550763, Compound I-142 P2X purinoceptor 3 Homo sapiens 26.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244390 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244390&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823152 376222089 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490900 Clc1ccc(Cn2c(=O)c(NC(=O)C3CCOCC3)c[nH]\c2=N/c2ccc(Oc3cnc(cn3)C#N)cc2)cc1 InChI=1S/C28H24ClN7O4/c29-20-3-1-18(2-4-20)17-36-27(38)24(35-26(37)19-9-11-39-12-10-19)15-33-28(36)34-21-5-7-23(8-6-21)40-25-16-31-22(13-30)14-32-25/h1-8,14-16,19H,9-12,17H2,(H,33,34)(H,35,37) YTVXHIYFAXHHCQ-UHFFFAOYSA-N 244391 US9550763, Compound I-143 P2X purinoceptor 3 Homo sapiens 2.00 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244391 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244391&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823153 376222090 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490901 CCc1c[nH]\c(=N/c2ccc(Oc3cccc(n3)C(O)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H21ClN4O4/c1-2-17-14-27-25(30(23(17)31)15-16-6-8-18(26)9-7-16)28-19-10-12-20(13-11-19)34-22-5-3-4-21(29-22)24(32)33/h3-14H,2,15H2,1H3,(H,27,28)(H,32,33) OSBOVXCJCKEVSM-UHFFFAOYSA-N 244416 US9550763, Compound I-144 P2X purinoceptor 3 Homo sapiens 35.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244416 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244416&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823154 376222091 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490902 CCC(=O)Nc1c[nH]\c(=N/c2ccc(Oc3cncc(C)n3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H23ClN6O3/c1-3-22(33)31-21-13-28-25(32(24(21)34)15-17-4-6-18(26)7-5-17)30-19-8-10-20(11-9-19)35-23-14-27-12-16(2)29-23/h4-14H,3,15H2,1-2H3,(H,28,30)(H,31,33) DSHUSKGDHVDGKX-UHFFFAOYSA-N 244526 US9550763, Compound I-145 P2X purinoceptor 3 Homo sapiens 40.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244526 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244526&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823155 376222092 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490903 CCC(=O)Nc1c[nH]\c(=N/c2ccc(Oc3ccc(C)nn3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H23ClN6O3/c1-3-22(33)29-21-14-27-25(32(24(21)34)15-17-5-7-18(26)8-6-17)28-19-9-11-20(12-10-19)35-23-13-4-16(2)30-31-23/h4-14H,3,15H2,1-2H3,(H,27,28)(H,29,33) FKDYEIRSQSJNJE-UHFFFAOYSA-N 244549 US9550763, Compound I-146 P2X purinoceptor 3 Homo sapiens 26.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244549 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244549&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823156 376222093 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490904 CC(=C)c1c[nH]\c(=N/c2ccc(Oc3cccc(n3)C#N)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H20ClN5O2/c1-17(2)23-15-29-26(32(25(23)33)16-18-6-8-19(27)9-7-18)31-20-10-12-22(13-11-20)34-24-5-3-4-21(14-28)30-24/h3-13,15H,1,16H2,2H3,(H,29,31) VJGPPKWRFNIPJM-UHFFFAOYSA-N 244660 US9550763, Compound I-147 P2X purinoceptor 3 Homo sapiens 112 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244660 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244660&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823157 376222094 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490905 CCc1c[nH]\c(=N/c2ccc(Oc3cccc(n3)C(O)=O)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H23ClN4O4/c1-3-18-14-28-26(31(24(18)32)15-17-7-9-19(27)10-8-17)29-20-11-12-22(16(2)13-20)35-23-6-4-5-21(30-23)25(33)34/h4-14H,3,15H2,1-2H3,(H,28,29)(H,33,34) AUFVLTFZRIWYNL-UHFFFAOYSA-N 244661 US9550763, Compound I-148 P2X purinoceptor 3 Homo sapiens 59.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244661 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244661&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823158 376222095 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490906 Cc1noc(n1)-c1c[nH]\c(=N/c2ccc(Oc3ccc(F)cn3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H18ClFN6O3/c1-15-30-23(36-32-15)21-13-29-25(33(24(21)34)14-16-2-4-17(26)5-3-16)31-19-7-9-20(10-8-19)35-22-11-6-18(27)12-28-22/h2-13H,14H2,1H3,(H,29,31) BUDAQNZNKYVFEG-UHFFFAOYSA-N 244662 US9550763, Compound I-151 P2X purinoceptor 3 Homo sapiens 31.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244662 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244662&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823159 376222096 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490907 Fc1ccc(Oc2ccc(cc2)\N=c2/[nH]ccc(=O)n2Cc2ccc(Cl)cc2)nc1 InChI=1S/C22H16ClFN4O2/c23-16-3-1-15(2-4-16)14-28-21(29)11-12-25-22(28)27-18-6-8-19(9-7-18)30-20-10-5-17(24)13-26-20/h1-13H,14H2,(H,25,27) UVLXLASXIPYJTO-UHFFFAOYSA-N 244663 US9550763, Compound I-152 P2X purinoceptor 3 Homo sapiens 291 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244663 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244663&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823160 376222097 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490908 CCOC(=O)c1c[nH]\c(=N/c2ccc(Oc3cccc(n3)C#N)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H20ClN5O4/c1-2-35-25(34)22-15-29-26(32(24(22)33)16-17-6-8-18(27)9-7-17)31-19-10-12-21(13-11-19)36-23-5-3-4-20(14-28)30-23/h3-13,15H,2,16H2,1H3,(H,29,31) HDLFXZNNEPWURG-UHFFFAOYSA-N 244668 US9550763, Compound I-153 P2X purinoceptor 3 Homo sapiens 21.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244668 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244668&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823161 376222098 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490909 CCc1cn(Cc2ccc(Cl)cc2)c(Nc2ccc(Oc3ncc(s3)C(O)=O)cc2)nc1=O InChI=1S/C23H19ClN4O4S/c1-2-15-13-28(12-14-3-5-16(24)6-4-14)22(27-20(15)29)26-17-7-9-18(10-8-17)32-23-25-11-19(33-23)21(30)31/h3-11,13H,2,12H2,1H3,(H,30,31)(H,26,27,29) KNXABSRQYFLODN-UHFFFAOYSA-N 244687 US9550763, Compound I-154 P2X purinoceptor 3 Homo sapiens 317 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244687 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244687&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 89745432 376222099 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490910 Fc1cccnc1Oc1ccc(Nc2nc(=O)c(cn2Cc2ccc(Cl)cc2)C(=O)NC2CCOCC2)cc1 InChI=1S/C28H25ClFN5O4/c29-19-5-3-18(4-6-19)16-35-17-23(25(36)32-21-11-14-38-15-12-21)26(37)34-28(35)33-20-7-9-22(10-8-20)39-27-24(30)2-1-13-31-27/h1-10,13,17,21H,11-12,14-16H2,(H,32,36)(H,33,34,37) JEJMIAKNSWDBKJ-UHFFFAOYSA-N 244688 US9550763, Compound I-155 P2X purinoceptor 3 Homo sapiens 17.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244688 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244688&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 89745433 376222100 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490911 Fc1cccc(Oc2ccc(Nc3nc(=O)c(cn3Cc3ccc(Cl)cc3)C(=O)NC3CCOCC3)cc2)n1 InChI=1S/C28H25ClFN5O4/c29-19-6-4-18(5-7-19)16-35-17-23(26(36)31-21-12-14-38-15-13-21)27(37)34-28(35)32-20-8-10-22(11-9-20)39-25-3-1-2-24(30)33-25/h1-11,17,21H,12-16H2,(H,31,36)(H,32,34,37) LBSQJWQBHOFEBH-UHFFFAOYSA-N 244689 US9550763, Compound I-156 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244689 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244689&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 89745157 376222101 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490912 Cc1cc(Nc2nc(=O)c(cn2Cc2ccc(Cl)cc2)C(=O)NC2CCOCC2)ccc1Oc1cccc(F)n1 InChI=1S/C29H27ClFN5O4/c1-18-15-22(9-10-24(18)40-26-4-2-3-25(31)34-26)33-29-35-28(38)23(27(37)32-21-11-13-39-14-12-21)17-36(29)16-19-5-7-20(30)8-6-19/h2-10,15,17,21H,11-14,16H2,1H3,(H,32,37)(H,33,35,38) GOJOTWOFIPQUEN-UHFFFAOYSA-N 244692 US9550763, Compound I-157 P2X purinoceptor 3 Homo sapiens 11.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244692 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244692&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 89745156 376222102 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490913 Fc1ccc(Oc2ccc(Nc3nc(=O)c(cn3Cc3ccc(Cl)cc3)C(=O)NC3CCOCC3)cc2)nc1 InChI=1S/C28H25ClFN5O4/c29-19-3-1-18(2-4-19)16-35-17-24(26(36)32-22-11-13-38-14-12-22)27(37)34-28(35)33-21-6-8-23(9-7-21)39-25-10-5-20(30)15-31-25/h1-10,15,17,22H,11-14,16H2,(H,32,36)(H,33,34,37) JYBSLMWDDRMMLD-UHFFFAOYSA-N 244693 US9550763, Compound I-158 P2X purinoceptor 3 Homo sapiens 11.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244693 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244693&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118683371 376222103 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490914 Cc1ccc(Oc2ccc(Nc3nc(=O)c(cn3Cc3ccc(Cl)cc3)C(=O)NC3CCOCC3)cc2)nn1 InChI=1S/C28H27ClN6O4/c1-18-2-11-25(34-33-18)39-23-9-7-21(8-10-23)31-28-32-27(37)24(26(36)30-22-12-14-38-15-13-22)17-35(28)16-19-3-5-20(29)6-4-19/h2-11,17,22H,12-16H2,1H3,(H,30,36)(H,31,32,37) CDPKXKWWAHSROH-UHFFFAOYSA-N 244694 US9550763, Compound I-159 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244694 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244694&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118683372 376222104 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490915 Cc1cc(Nc2nc(=O)c(cn2Cc2ccc(Cl)cc2)C(=O)NC2CCOCC2)ccc1Oc1ncccc1F InChI=1S/C29H27ClFN5O4/c1-18-15-22(8-9-25(18)40-28-24(31)3-2-12-32-28)34-29-35-27(38)23(26(37)33-21-10-13-39-14-11-21)17-36(29)16-19-4-6-20(30)7-5-19/h2-9,12,15,17,21H,10-11,13-14,16H2,1H3,(H,33,37)(H,34,35,38) CKMROQZPWJEDAQ-UHFFFAOYSA-N 244697 US9550763, Compound I-160 P2X purinoceptor 3 Homo sapiens 26.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244697 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244697&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118683373 376222105 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490916 Clc1ccc(Cn2cc(C(=O)NC3CCOCC3)c(=O)nc2Nc2ccc(Oc3nccs3)cc2)cc1 InChI=1S/C26H24ClN5O4S/c27-18-3-1-17(2-4-18)15-32-16-22(23(33)29-20-9-12-35-13-10-20)24(34)31-25(32)30-19-5-7-21(8-6-19)36-26-28-11-14-37-26/h1-8,11,14,16,20H,9-10,12-13,15H2,(H,29,33)(H,30,31,34) SVTMSWPEZYNSNG-UHFFFAOYSA-N 244699 US9550763, Compound I-161 P2X purinoceptor 3 Homo sapiens 22.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244699 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244699&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 71726731 376222106 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490917 Cc1cc(ccc1Oc1ncccc1F)\N=c1/[nH]cc(NC(=O)C2CCOCC2)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C29H27ClFN5O4/c1-18-15-22(8-9-25(18)40-27-23(31)3-2-12-32-27)34-29-33-16-24(35-26(37)20-10-13-39-14-11-20)28(38)36(29)17-19-4-6-21(30)7-5-19/h2-9,12,15-16,20H,10-11,13-14,17H2,1H3,(H,33,34)(H,35,37) IBAYRVLKJNDIQR-UHFFFAOYSA-N 244701 US9550763, Compound I-162 P2X purinoceptor 3 Homo sapiens 3.00 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244701 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244701&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823162 376222107 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490918 CCC(=O)Nc1c[nH]\c(=N/c2ccc(Oc3ccnc(CO)c3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H24ClN5O4/c1-2-24(34)31-23-14-29-26(32(25(23)35)15-17-3-5-18(27)6-4-17)30-19-7-9-21(10-8-19)36-22-11-12-28-20(13-22)16-33/h3-14,33H,2,15-16H2,1H3,(H,29,30)(H,31,34) AWSKHNBUHKCLHI-UHFFFAOYSA-N 244702 US9550763, Compound I-163 P2X purinoceptor 3 Homo sapiens 21.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244702 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244702&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823163 376222108 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490919 CCCn1c(=O)cc(Nc2ccc(Oc3cccc(n3)C#N)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H22ClN5O3/c1-2-14-31-25(33)15-23(32(26(31)34)17-18-6-8-19(27)9-7-18)29-20-10-12-22(13-11-20)35-24-5-3-4-21(16-28)30-24/h3-13,15,29H,2,14,17H2,1H3 AKRYEYGNAQPORG-UHFFFAOYSA-N 244706 US9550763, Compound I-164 P2X purinoceptor 3 Homo sapiens 10.00 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244706 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244706&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823164 376222109 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490920 CCCn1c(=O)cc(Nc2ccc(Oc3cccc(n3)C(O)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H23ClN4O5/c1-2-14-30-24(32)15-22(31(26(30)35)16-17-6-8-18(27)9-7-17)28-19-10-12-20(13-11-19)36-23-5-3-4-21(29-23)25(33)34/h3-13,15,28H,2,14,16H2,1H3,(H,33,34) NTXFJFCTEWMVLQ-UHFFFAOYSA-N 244707 US9550763, Compound I-165 P2X purinoceptor 3 Homo sapiens 3.00 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244707 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244707&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823165 376222110 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490921 CCCn1c(=O)cc(Nc2ccc(Oc3cccc(c3)C(=O)OCC)cn2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C28H27ClN4O5/c1-3-14-32-26(34)16-25(33(28(32)36)18-19-8-10-21(29)11-9-19)31-24-13-12-23(17-30-24)38-22-7-5-6-20(15-22)27(35)37-4-2/h5-13,15-17H,3-4,14,18H2,1-2H3,(H,30,31) BMGBHHWKELXUAJ-UHFFFAOYSA-N 244708 US9550763, Compound I-166 P2X purinoceptor 3 Homo sapiens 169 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244708 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244708&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823166 376222111 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490922 CCCn1c(=O)cc(Nc2ccc(Oc3cccc(c3)C(O)=O)cn2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H23ClN4O5/c1-2-12-30-24(32)14-23(31(26(30)35)16-17-6-8-19(27)9-7-17)29-22-11-10-21(15-28-22)36-20-5-3-4-18(13-20)25(33)34/h3-11,13-15H,2,12,16H2,1H3,(H,28,29)(H,33,34) PSXANVJIDDMMLV-UHFFFAOYSA-N 244709 US9550763, Compound I-167 P2X purinoceptor 3 Homo sapiens 35.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244709 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244709&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823167 376222112 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490923 CCCn1c(=O)cc(Nc2ccc(Oc3cccc(c3)C(=O)OC)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C28H26ClN3O5/c1-3-15-31-26(33)17-25(32(28(31)35)18-19-7-9-21(29)10-8-19)30-22-11-13-23(14-12-22)37-24-6-4-5-20(16-24)27(34)36-2/h4-14,16-17,30H,3,15,18H2,1-2H3 ZDIGFIUBMDUNEJ-UHFFFAOYSA-N 244710 US9550763, Compound I-168 P2X purinoceptor 3 Homo sapiens 159 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244710 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244710&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823168 376222113 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490924 CCCn1c(=O)cc(Nc2ccc(Oc3cccc(c3)C(O)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C27H24ClN3O5/c1-2-14-30-25(32)16-24(31(27(30)35)17-18-6-8-20(28)9-7-18)29-21-10-12-22(13-11-21)36-23-5-3-4-19(15-23)26(33)34/h3-13,15-16,29H,2,14,17H2,1H3,(H,33,34) ALUKORJJHUEQMP-UHFFFAOYSA-N 244711 US9550763, Compound I-169 P2X purinoceptor 3 Homo sapiens 11.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244711 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244711&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823169 376222114 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490925 CCc1c[nH]\c(=N/c2ccc(Oc3cncc(c3)C(O)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H21ClN4O4/c1-2-17-13-28-25(30(23(17)31)15-16-3-5-19(26)6-4-16)29-20-7-9-21(10-8-20)34-22-11-18(24(32)33)12-27-14-22/h3-14H,2,15H2,1H3,(H,28,29)(H,32,33) SCPZJXCFYVDLAJ-UHFFFAOYSA-N 244712 US9550763, Compound I-170 P2X purinoceptor 3 Homo sapiens 54.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244712 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244712&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823170 376222115 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490926 CCCn1c(=O)cc(Nc2ccc(Oc3cccc(n3)C#N)cn2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H21ClN6O3/c1-2-12-31-24(33)13-22(32(25(31)34)16-17-6-8-18(26)9-7-17)30-21-11-10-20(15-28-21)35-23-5-3-4-19(14-27)29-23/h3-11,13,15H,2,12,16H2,1H3,(H,28,30) XMASGIWZDJAJBF-UHFFFAOYSA-N 244713 US9550763, Compound I-171 P2X purinoceptor 3 Homo sapiens 21.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244713 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244713&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823171 376222116 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490927 CCCn1c(=O)cc(Nc2ccc(Oc3cccc(n3)C(O)=O)cn2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H22ClN5O5/c1-2-12-30-23(32)13-21(31(25(30)35)15-16-6-8-17(26)9-7-16)29-20-11-10-18(14-27-20)36-22-5-3-4-19(28-22)24(33)34/h3-11,13-14H,2,12,15H2,1H3,(H,27,29)(H,33,34) AWQSCGZABDNRMM-UHFFFAOYSA-N 244714 US9550763, Compound I-172 P2X purinoceptor 3 Homo sapiens 16.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244714 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244714&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823172 376222117 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490928 CCn1c(=O)cc(Nc2ccc(Oc3ccc(nn3)C(=O)OC)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H22ClN5O5/c1-3-30-23(32)14-21(31(25(30)34)15-16-4-6-17(26)7-5-16)27-18-8-10-19(11-9-18)36-22-13-12-20(28-29-22)24(33)35-2/h4-14,27H,3,15H2,1-2H3 INTFKLYDKORJQY-UHFFFAOYSA-N 244715 US9550763, Compound I-173 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244715 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244715&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823173 376222118 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490929 CCn1c(=O)cc(Nc2ccc(Oc3ccc(nn3)C(O)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H20ClN5O5/c1-2-29-22(31)13-20(30(24(29)34)14-15-3-5-16(25)6-4-15)26-17-7-9-18(10-8-17)35-21-12-11-19(23(32)33)27-28-21/h3-13,26H,2,14H2,1H3,(H,32,33) AVYODQXEEXGYDM-UHFFFAOYSA-N 244716 US9550763, Compound I-174 P2X purinoceptor 3 Homo sapiens 36.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244716 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244716&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823174 376222119 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490930 Clc1ccc(Cn2cc(C(=O)NC3CCOCC3)c(=O)nc2Nc2ccc(Oc3ccon3)cc2)cc1 InChI=1S/C26H24ClN5O5/c27-18-3-1-17(2-4-18)15-32-16-22(24(33)28-20-9-12-35-13-10-20)25(34)30-26(32)29-19-5-7-21(8-6-19)37-23-11-14-36-31-23/h1-8,11,14,16,20H,9-10,12-13,15H2,(H,28,33)(H,29,30,34) SLPCTZSWJHFLBH-UHFFFAOYSA-N 244717 US9550763, Compound I-175 P2X purinoceptor 3 Homo sapiens 37.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244717 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244717&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 89745442 376222120 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490931 CCOC(=O)c1c[nH]\c(=N/c2ccc(Oc3ccc(C)nn3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H22ClN5O4/c1-3-34-24(33)21-14-27-25(31(23(21)32)15-17-5-7-18(26)8-6-17)28-19-9-11-20(12-10-19)35-22-13-4-16(2)29-30-22/h4-14H,3,15H2,1-2H3,(H,27,28) QNAPPXIFRKZMRQ-UHFFFAOYSA-N 244718 US9550763, Compound I-177 P2X purinoceptor 3 Homo sapiens 14.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244718 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244718&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823175 376222121 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490932 NC(=O)c1cccc(Oc2ccc(cc2)\N=c2/[nH]cc(C(N)=O)c(=O)n2Cc2ccc(Cl)cc2)n1 InChI=1S/C24H19ClN6O4/c25-15-6-4-14(5-7-15)13-31-23(34)18(21(26)32)12-28-24(31)29-16-8-10-17(11-9-16)35-20-3-1-2-19(30-20)22(27)33/h1-12H,13H2,(H2,26,32)(H2,27,33)(H,28,29) ZLKYDKMBGSKVCG-UHFFFAOYSA-N 244723 US9550763, Compound I-178 P2X purinoceptor 3 Homo sapiens 14.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244723 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244723&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823176 376222122 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490933 Cc1ccc(Oc2ccc(cc2)\N=c2/[nH]cc(C(O)=O)c(=O)n2Cc2ccc(Cl)cc2)nn1 InChI=1S/C23H18ClN5O4/c1-14-2-11-20(28-27-14)33-18-9-7-17(8-10-18)26-23-25-12-19(22(31)32)21(30)29(23)13-15-3-5-16(24)6-4-15/h2-12H,13H2,1H3,(H,25,26)(H,31,32) VETZFUJRDWOXIR-UHFFFAOYSA-N 244724 US9550763, Compound I-179 P2X purinoceptor 3 Homo sapiens 359 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244724 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244724&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823177 376222123 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490934 Cc1ccc(Oc2ccc(cc2)\N=c2/[nH]cc(C(N)=O)c(=O)n2Cc2ccc(Cl)cc2)nn1 InChI=1S/C23H19ClN6O3/c1-14-2-11-20(29-28-14)33-18-9-7-17(8-10-18)27-23-26-12-19(21(25)31)22(32)30(23)13-15-3-5-16(24)6-4-15/h2-12H,13H2,1H3,(H2,25,31)(H,26,27) UKLDBJKNFBBPJB-UHFFFAOYSA-N 244725 US9550763, Compound I-180 P2X purinoceptor 3 Homo sapiens 21.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244725 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244725&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823178 376222124 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490935 Clc1ccc(Cn2c(=O)c(NC(=O)C3CNC3)c[nH]\c2=N/c2ccc(Oc3ccon3)cc2)cc1 InChI=1S/C24H21ClN6O4/c25-17-3-1-15(2-4-17)14-31-23(33)20(29-22(32)16-11-26-12-16)13-27-24(31)28-18-5-7-19(8-6-18)35-21-9-10-34-30-21/h1-10,13,16,26H,11-12,14H2,(H,27,28)(H,29,32) WQJJEDKBOOVTNQ-UHFFFAOYSA-N 244726 US9550763, Compound I-181 P2X purinoceptor 3 Homo sapiens 131 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244726 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244726&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823179 376222125 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490936 CC(C)(C)OC(=O)N1CCC(CC1)C(=O)Nc1c[nH]\c(=N/c2ccc(Oc3ccon3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C31H33ClN6O6/c1-31(2,3)44-30(41)37-15-12-21(13-16-37)27(39)35-25-18-33-29(38(28(25)40)19-20-4-6-22(32)7-5-20)34-23-8-10-24(11-9-23)43-26-14-17-42-36-26/h4-11,14,17-18,21H,12-13,15-16,19H2,1-3H3,(H,33,34)(H,35,39) NQCSEOAZTYROML-UHFFFAOYSA-N 244727 US9550763, Compound I-182 P2X purinoceptor 3 Homo sapiens 52.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244727 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244727&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823180 376222126 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490937 O[C@H]1C[C@@H](C1)C(=O)Nc1c[nH]\c(=N/c2ccc(Oc3ccon3)cc2)n(Cc2ccc(Cl)cc2)c1=O 244728 US9550763, Compound I-183 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244728 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244728&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823181 376222127 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490938 Clc1ccc(Cn2c(=O)c(NC(=O)C3COC3)c[nH]\c2=N/c2ccc(Oc3ccon3)cc2)cc1 InChI=1S/C24H20ClN5O5/c25-17-3-1-15(2-4-17)12-30-23(32)20(28-22(31)16-13-33-14-16)11-26-24(30)27-18-5-7-19(8-6-18)35-21-9-10-34-29-21/h1-11,16H,12-14H2,(H,26,27)(H,28,31) BOFLSWPBXVAUEQ-UHFFFAOYSA-N 244729 US9550763, Compound I-184 P2X purinoceptor 3 Homo sapiens 14.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244729 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244729&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823182 376222128 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490939 CN(C)CCC(=O)Nc1c[nH]\c(=N/c2ccc(Oc3ccon3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H25ClN6O4/c1-31(2)13-11-22(33)29-21-15-27-25(32(24(21)34)16-17-3-5-18(26)6-4-17)28-19-7-9-20(10-8-19)36-23-12-14-35-30-23/h3-10,12,14-15H,11,13,16H2,1-2H3,(H,27,28)(H,29,33) OVLXKWGOUQYKAV-UHFFFAOYSA-N 244730 US9550763, Compound I-185 P2X purinoceptor 3 Homo sapiens 158 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244730 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244730&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823183 376222129 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490940 Clc1ccc(Cn2c(=O)c(NC(=O)C3CCNCC3)c[nH]\c2=N/c2ccc(Oc3ccon3)cc2)cc1 InChI=1S/C26H25ClN6O4/c27-19-3-1-17(2-4-19)16-33-25(35)22(31-24(34)18-9-12-28-13-10-18)15-29-26(33)30-20-5-7-21(8-6-20)37-23-11-14-36-32-23/h1-8,11,14-15,18,28H,9-10,12-13,16H2,(H,29,30)(H,31,34) HRLUEVHANQNNNU-UHFFFAOYSA-N 244731 US9550763, Compound I-186 P2X purinoceptor 3 Homo sapiens 72.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244731 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244731&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823184 376222130 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490941 CCCn1c(=O)cc(Nc2ccc(Oc3cccc(n3)C#N)c(C)n2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H23ClN6O3/c1-3-13-32-25(34)14-23(33(26(32)35)16-18-7-9-19(27)10-8-18)31-22-12-11-21(17(2)29-22)36-24-6-4-5-20(15-28)30-24/h4-12,14H,3,13,16H2,1-2H3,(H,29,31) SAEBWGDXPFVXEP-UHFFFAOYSA-N 244732 US9550763, Compound I-187 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244732 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244732&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823185 376222131 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490942 CCCn1c(=O)cc(Nc2ccc(Oc3cccc(n3)C(O)=O)c(C)n2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H24ClN5O5/c1-3-13-31-24(33)14-22(32(26(31)36)15-17-7-9-18(27)10-8-17)30-21-12-11-20(16(2)28-21)37-23-6-4-5-19(29-23)25(34)35/h4-12,14H,3,13,15H2,1-2H3,(H,28,30)(H,34,35) DXFZLYOMWPVBQO-UHFFFAOYSA-N 244733 US9550763, Compound I-188 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244733 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244733&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823186 376222132 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490943 CCN(C(=O)CC)c1c[nH]\c(=N/c2ccc(Oc3cccc(n3)C#N)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C28H25ClN6O3/c1-3-26(36)34(4-2)24-17-31-28(35(27(24)37)18-19-8-10-20(29)11-9-19)33-21-12-14-23(15-13-21)38-25-7-5-6-22(16-30)32-25/h5-15,17H,3-4,18H2,1-2H3,(H,31,33) HFQASQNLXZTMSJ-UHFFFAOYSA-N 244741 US9550763, Compound I-189 P2X purinoceptor 3 Homo sapiens 12.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244741 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244741&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823187 376222133 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490944 Cc1noc(n1)-c1cn(Cc2ccc(Cl)cc2)\c(=N\c2ccc(Oc3cccc(F)n3)cc2)[nH]c1=O InChI=1S/C25H18ClFN6O3/c1-15-28-24(36-32-15)20-14-33(13-16-5-7-17(26)8-6-16)25(31-23(20)34)29-18-9-11-19(12-10-18)35-22-4-2-3-21(27)30-22/h2-12,14H,13H2,1H3,(H,29,31,34) NXVORBLLFDACQC-UHFFFAOYSA-N 244763 US9550763, Compound I-190 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244763 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244763&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823188 376222134 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490945 Clc1ccc(Cn2c(=O)c(NC(=O)C3CCOC3)c[nH]\c2=N/c2ccc(Oc3ccon3)cc2)cc1 244774 US9550763, Compound I-192::US9550763, Compound I-212::US9550763, Compound I-213 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244774 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244774&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823189 376222135 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490946 CCN(C(=O)CC)c1c[nH]\c(=N/c2ccc(Oc3cccc(n3)C(O)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C28H26ClN5O5/c1-3-25(35)33(4-2)23-16-30-28(34(26(23)36)17-18-8-10-19(29)11-9-18)31-20-12-14-21(15-13-20)39-24-7-5-6-22(32-24)27(37)38/h5-16H,3-4,17H2,1-2H3,(H,30,31)(H,37,38) AJXZBMNBRKJBBY-UHFFFAOYSA-N 244775 US9550763, Compound I-193 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244775 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244775&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823190 376222136 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490947 Oc1ncccc1-c1c[nH]\c(=N/c2ccc(Oc3ccon3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H18ClN5O4/c26-17-5-3-16(4-6-17)15-31-24(33)21(20-2-1-12-27-23(20)32)14-28-25(31)29-18-7-9-19(10-8-18)35-22-11-13-34-30-22/h1-14H,15H2,(H,27,32)(H,28,29) LABVDERRTNLEJK-UHFFFAOYSA-N 244776 US9550763, Compound I-194 P2X purinoceptor 3 Homo sapiens 658 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244776 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244776&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823191 376222137 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490948 CN(C)C(=O)c1c[nH]\c(=N/c2ccc(Oc3cccc(F)n3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H21ClFN5O3/c1-31(2)23(33)20-14-28-25(32(24(20)34)15-16-6-8-17(26)9-7-16)29-18-10-12-19(13-11-18)35-22-5-3-4-21(27)30-22/h3-14H,15H2,1-2H3,(H,28,29) AYPYCROYPQJHTN-UHFFFAOYSA-N 244777 US9550763, Compound I-195 P2X purinoceptor 3 Homo sapiens 70.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244777 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244777&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823192 376222138 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490949 CCCn1c(=O)cc(Nc2ccc(Oc3cnc(nc3)C#N)cn2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H20ClN7O3/c1-2-9-31-23(33)10-22(32(24(31)34)15-16-3-5-17(25)6-4-16)30-20-8-7-18(12-27-20)35-19-13-28-21(11-26)29-14-19/h3-8,10,12-14H,2,9,15H2,1H3,(H,27,30) BJPAZJBTVJTCQX-UHFFFAOYSA-N 244778 US9550763, Compound I-196 P2X purinoceptor 3 Homo sapiens 37.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244778 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244778&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823193 376222139 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490950 CN(C(C)=O)c1c[nH]\c(=N/c2ccc(Oc3cccc(n3)C#N)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H21ClN6O3/c1-17(34)32(2)23-15-29-26(33(25(23)35)16-18-6-8-19(27)9-7-18)31-20-10-12-22(13-11-20)36-24-5-3-4-21(14-28)30-24/h3-13,15H,16H2,1-2H3,(H,29,31) JVJJMVPRIZZBHW-UHFFFAOYSA-N 244779 US9550763, Compound I-197 P2X purinoceptor 3 Homo sapiens 45.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244779 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244779&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823194 376222140 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490951 CCC(=O)N(C)c1c[nH]\c(=N/c2ccc(Oc3cccc(n3)C#N)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C27H23ClN6O3/c1-3-25(35)33(2)23-16-30-27(34(26(23)36)17-18-7-9-19(28)10-8-18)32-20-11-13-22(14-12-20)37-24-6-4-5-21(15-29)31-24/h4-14,16H,3,17H2,1-2H3,(H,30,32) NASUZMARAIAZFC-UHFFFAOYSA-N 244780 US9550763, Compound I-198 P2X purinoceptor 3 Homo sapiens 12.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244780 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244780&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823195 376222141 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490952 Clc1ccc(Cn2cc(C(=O)NC3CCOCC3)c(=O)nc2Nc2ccc(Oc3ccncc3)cc2)cc1 InChI=1S/C28H26ClN5O4/c29-20-3-1-19(2-4-20)17-34-18-25(26(35)31-22-11-15-37-16-12-22)27(36)33-28(34)32-21-5-7-23(8-6-21)38-24-9-13-30-14-10-24/h1-10,13-14,18,22H,11-12,15-17H2,(H,31,35)(H,32,33,36) TVKLTNAGWZXUNT-UHFFFAOYSA-N 244781 US9550763, Compound I-199 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244781 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244781&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118683388 376222142 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490953 NC(=O)c1ccc(Oc2ccc(Nc3nc(=O)c(cn3Cc3ccc(Cl)cc3)C(=O)NC3CCOCC3)cc2)cn1 InChI=1S/C29H27ClN6O5/c30-19-3-1-18(2-4-19)16-36-17-24(27(38)33-21-11-13-40-14-12-21)28(39)35-29(36)34-20-5-7-22(8-6-20)41-23-9-10-25(26(31)37)32-15-23/h1-10,15,17,21H,11-14,16H2,(H2,31,37)(H,33,38)(H,34,35,39) ULHCULYXIPYUGU-UHFFFAOYSA-N 244782 US9550763, Compound I-200 P2X purinoceptor 3 Homo sapiens 10.00 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244782 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244782&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118683389 376222143 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490954 CCCn1c(=O)cc(Nc2ccc(Oc3cnc(nc3)C(O)=O)cn2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H21ClN6O5/c1-2-9-30-21(32)10-20(31(24(30)35)14-15-3-5-16(25)6-4-15)29-19-8-7-17(11-26-19)36-18-12-27-22(23(33)34)28-13-18/h3-8,10-13H,2,9,14H2,1H3,(H,26,29)(H,33,34) AKTWKNSZAAYZRW-UHFFFAOYSA-N 244783 US9550763, Compound I-201 P2X purinoceptor 3 Homo sapiens 96.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244783 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244783&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823196 376222144 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490955 CCn1c(=O)cc(Nc2cc(C)c(Oc3cccc(c3)C(O)=O)cn2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H23ClN4O5/c1-3-30-24(32)13-23(31(26(30)35)15-17-7-9-19(27)10-8-17)29-22-11-16(2)21(14-28-22)36-20-6-4-5-18(12-20)25(33)34/h4-14H,3,15H2,1-2H3,(H,28,29)(H,33,34) MWBVONUHCZGPOT-UHFFFAOYSA-N 244784 US9550763, Compound I-203 P2X purinoceptor 3 Homo sapiens 336 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244784 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244784&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823197 376222145 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490956 COc1ccc(cn1)-c1c[nH]\c(=N/c2ccc(Oc3ccon3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H20ClN5O4/c1-34-23-11-4-18(14-28-23)22-15-29-26(32(25(22)33)16-17-2-5-19(27)6-3-17)30-20-7-9-21(10-8-20)36-24-12-13-35-31-24/h2-15H,16H2,1H3,(H,29,30) IQGMDGAJNCQIRB-UHFFFAOYSA-N 244785 US9550763, Compound I-204 P2X purinoceptor 3 Homo sapiens 198 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244785 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244785&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823198 376222146 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490957 Oc1ccc(cn1)-c1c[nH]\c(=N/c2ccc(Oc3ccon3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H18ClN5O4/c26-18-4-1-16(2-5-18)15-31-24(33)21(17-3-10-22(32)27-13-17)14-28-25(31)29-19-6-8-20(9-7-19)35-23-11-12-34-30-23/h1-14H,15H2,(H,27,32)(H,28,29) SJUUUAUAOHDELK-UHFFFAOYSA-N 244786 US9550763, Compound I-205 P2X purinoceptor 3 Homo sapiens 153 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244786 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244786&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823199 376222147 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490958 CCOC(=O)c1c[nH]\c(=N/c2ccc(Oc3ccc(F)cn3)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H19ClF2N4O4/c1-2-35-24(34)19-13-30-25(32(23(19)33)14-15-3-5-16(26)6-4-15)31-18-8-9-21(20(28)11-18)36-22-10-7-17(27)12-29-22/h3-13H,2,14H2,1H3,(H,30,31) TZMHTNLFTDEWCV-UHFFFAOYSA-N 244787 US9550763, Compound I-206 P2X purinoceptor 3 Homo sapiens 48.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244787 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244787&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823200 376222148 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490959 OC(=O)c1c[nH]\c(=N/c2ccc(Oc3ccc(F)cn3)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H15ClF2N4O4/c24-14-3-1-13(2-4-14)12-30-21(31)17(22(32)33)11-28-23(30)29-16-6-7-19(18(26)9-16)34-20-8-5-15(25)10-27-20/h1-11H,12H2,(H,28,29)(H,32,33) IARIZKVEEOGSSV-UHFFFAOYSA-N 244788 US9550763, Compound I-207 P2X purinoceptor 3 Homo sapiens 252 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244788 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244788&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823201 376222149 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490960 NC(=O)c1c[nH]\c(=N/c2ccc(Oc3ccc(F)cn3)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H16ClF2N5O3/c24-14-3-1-13(2-4-14)12-31-22(33)17(21(27)32)11-29-23(31)30-16-6-7-19(18(26)9-16)34-20-8-5-15(25)10-28-20/h1-11H,12H2,(H2,27,32)(H,29,30) FSIGKZALODOWFS-UHFFFAOYSA-N 244789 US9550763, Compound I-208 P2X purinoceptor 3 Homo sapiens 31.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244789 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244789&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823202 376222150 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490961 CN(C)C(=O)c1c[nH]\c(=N/c2ccc(Oc3cccc(n3)C#N)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H21ClN6O3/c1-32(2)24(34)22-15-29-26(33(25(22)35)16-17-6-8-18(27)9-7-17)31-19-10-12-21(13-11-19)36-23-5-3-4-20(14-28)30-23/h3-13,15H,16H2,1-2H3,(H,29,31) YUFUDILMFUHRSF-UHFFFAOYSA-N 244790 US9550763, Compound I-209 P2X purinoceptor 3 Homo sapiens 102 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244790 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244790&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823203 376222151 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490962 CN(C(C)=O)c1c[nH]\c(=N/c2ccc(Oc3cccc(n3)C(O)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H22ClN5O5/c1-16(33)31(2)22-14-28-26(32(24(22)34)15-17-6-8-18(27)9-7-17)29-19-10-12-20(13-11-19)37-23-5-3-4-21(30-23)25(35)36/h3-14H,15H2,1-2H3,(H,28,29)(H,35,36) ROGREUAGKWOSQZ-UHFFFAOYSA-N 245140 US9550763, Compound I-210 P2X purinoceptor 3 Homo sapiens 17.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=245140 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=245140&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823204 376222152 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490963 FC1(F)CC(C1)C(=O)Nc1c[nH]\c(=N/c2ccc(Oc3ccon3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H20ClF2N5O4/c26-17-3-1-15(2-4-17)14-33-23(35)20(31-22(34)16-11-25(27,28)12-16)13-29-24(33)30-18-5-7-19(8-6-18)37-21-9-10-36-32-21/h1-10,13,16H,11-12,14H2,(H,29,30)(H,31,34) RREXYWMGZAQLCH-UHFFFAOYSA-N 245142 US9550763, Compound I-211 P2X purinoceptor 3 Homo sapiens 15.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=245142 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=245142&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823205 376222153 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490964 Clc1ccc(Cn2c(=O)c(NC(=O)C3CCOC3)c[nH]\c2=N/c2ccc(Oc3ccon3)cc2)cc1 244774 US9550763, Compound I-192::US9550763, Compound I-212::US9550763, Compound I-213 P2X purinoceptor 3 Homo sapiens 11.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244774 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244774&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823189 376222135 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490965 Clc1ccc(Cn2c(=O)c(NC(=O)C3CCOC3)c[nH]\c2=N/c2ccc(Oc3ccon3)cc2)cc1 244774 US9550763, Compound I-192::US9550763, Compound I-212::US9550763, Compound I-213 P2X purinoceptor 3 Homo sapiens 27.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244774 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244774&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823189 376222135 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490966 Fc1ccc(Oc2ccc(cc2)\N=c2/[nH]cc(NC(=O)C3COC3)c(=O)n2Cc2ccc(Cl)cc2)nc1 InChI=1S/C26H21ClFN5O4/c27-18-3-1-16(2-4-18)13-33-25(35)22(32-24(34)17-14-36-15-17)12-30-26(33)31-20-6-8-21(9-7-20)37-23-10-5-19(28)11-29-23/h1-12,17H,13-15H2,(H,30,31)(H,32,34) PWOLHEAXPFXBRU-UHFFFAOYSA-N 245179 US9550763, Compound I-214 P2X purinoceptor 3 Homo sapiens 13.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=245179 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=245179&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823206 376222154 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490967 O[C@H]1C[C@@H](C1)C(=O)Nc1c[nH]\c(=N/c2ccc(Oc3ccc(F)cn3)cc2)n(Cc2ccc(Cl)cc2)c1=O 245180 US9550763, Compound I-215 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=245180 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=245180&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823207 376222155 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490968 Clc1ccc(Cn2cc(C(=O)NC3CCOCC3)c(=O)nc2Nc2ccc(Oc3cccc(n3)C#N)cc2)cc1 InChI=1S/C29H25ClN6O4/c30-20-6-4-19(5-7-20)17-36-18-25(27(37)33-22-12-14-39-15-13-22)28(38)35-29(36)34-21-8-10-24(11-9-21)40-26-3-1-2-23(16-31)32-26/h1-11,18,22H,12-15,17H2,(H,33,37)(H,34,35,38) GBYSGRDRZFEAOJ-UHFFFAOYSA-N 245181 US9550763, Compound I-216 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=245181 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=245181&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118683399 376222156 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490969 NC(=O)c1cccc(Oc2ccc(Nc3nc(=O)c(cn3Cc3ccc(Cl)cc3)C(=O)NC3CCOCC3)cc2)n1 InChI=1S/C29H27ClN6O5/c30-19-6-4-18(5-7-19)16-36-17-23(27(38)32-21-12-14-40-15-13-21)28(39)35-29(36)33-20-8-10-22(11-9-20)41-25-3-1-2-24(34-25)26(31)37/h1-11,17,21H,12-16H2,(H2,31,37)(H,32,38)(H,33,35,39) YDCRGYSTKPLWNV-UHFFFAOYSA-N 245182 US9550763, Compound I-217 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=245182 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=245182&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 89745196 376222157 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490970 F[C@H]1C[C@@H](C1)C(=O)Nc1c[nH]\c(=N/c2ccc(Oc3ccon3)cc2)n(Cc2ccc(Cl)cc2)c1=O 245183 US9550763, Compound I-218 P2X purinoceptor 3 Homo sapiens 17.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=245183 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=245183&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823208 376222158 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490971 F[C@H]1C[C@H](C1)C(=O)Nc1c[nH]\c(=N/c2ccc(Oc3ccon3)cc2)n(Cc2ccc(Cl)cc2)c1=O 245184 US9550763, Compound I-219 P2X purinoceptor 3 Homo sapiens 14.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=245184 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=245184&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823208 376222159 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490972 CN(C)C(=O)c1c[nH]\c(=N/c2ccc(Oc3cccc(n3)C(N)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H23ClN6O4/c1-32(2)24(35)20-14-29-26(33(25(20)36)15-16-6-8-17(27)9-7-16)30-18-10-12-19(13-11-18)37-22-5-3-4-21(31-22)23(28)34/h3-14H,15H2,1-2H3,(H2,28,34)(H,29,30) RIKRNVWPSPCSOH-UHFFFAOYSA-N 245185 US9550763, Compound I-220 P2X purinoceptor 3 Homo sapiens 178 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=245185 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=245185&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823209 376222160 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490973 CN(C)C(=O)c1c[nH]\c(=N/c2ccc(Oc3nc(C)ns3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H21ClN6O3S/c1-14-26-23(34-28-14)33-18-10-8-17(9-11-18)27-22-25-12-19(20(31)29(2)3)21(32)30(22)13-15-4-6-16(24)7-5-15/h4-12H,13H2,1-3H3,(H,25,27) MDAAXSUANHIGPE-UHFFFAOYSA-N 245186 US9550763, Compound I-221 P2X purinoceptor 3 Homo sapiens 65.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=245186 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=245186&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823210 376222161 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490974 CN(C)C(=O)c1c[nH]\c(=N/c2ccc(Oc3cccc(n3)C(O)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H22ClN5O5/c1-31(2)23(33)20-14-28-26(32(24(20)34)15-16-6-8-17(27)9-7-16)29-18-10-12-19(13-11-18)37-22-5-3-4-21(30-22)25(35)36/h3-14H,15H2,1-2H3,(H,28,29)(H,35,36) PAYILAZVXPDGKA-UHFFFAOYSA-N 245187 US9550763, Compound I-222 P2X purinoceptor 3 Homo sapiens 47.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=245187 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=245187&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823211 376222162 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490975 Clc1ccc(Cn2c(=O)c(NC(=O)c3ccno3)c[nH]\c2=N/c2ccc(Oc3ccon3)cc2)cc1 InChI=1S/C24H17ClN6O5/c25-16-3-1-15(2-4-16)14-31-23(33)19(29-22(32)20-9-11-27-36-20)13-26-24(31)28-17-5-7-18(8-6-17)35-21-10-12-34-30-21/h1-13H,14H2,(H,26,28)(H,29,32) WOMZWBKKGHCBEF-UHFFFAOYSA-N 245188 US9550763, Compound I-223 P2X purinoceptor 3 Homo sapiens 78.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=245188 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=245188&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823212 376222163 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490976 Cc1nsc(Oc2ccc(cc2)\N=c2/[nH]cc(NC(=O)C3CCOCC3)c(=O)n2Cc2ccc(Cl)cc2)n1 InChI=1S/C26H25ClN6O4S/c1-16-29-26(38-32-16)37-21-8-6-20(7-9-21)30-25-28-14-22(31-23(34)18-10-12-36-13-11-18)24(35)33(25)15-17-2-4-19(27)5-3-17/h2-9,14,18H,10-13,15H2,1H3,(H,28,30)(H,31,34) LUJRZVWZAZNYKE-UHFFFAOYSA-N 245189 US9550763, Compound I-225 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=245189 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=245189&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823213 376222164 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490977 Clc1ccc(Cn2c(=O)c(NC(=O)c3ccon3)c[nH]\c2=N/c2ccc(Oc3ccon3)cc2)cc1 InChI=1S/C24H17ClN6O5/c25-16-3-1-15(2-4-16)14-31-23(33)20(28-22(32)19-9-11-34-29-19)13-26-24(31)27-17-5-7-18(8-6-17)36-21-10-12-35-30-21/h1-13H,14H2,(H,26,27)(H,28,32) OTOWLLIXRHLTRU-UHFFFAOYSA-N 245190 US9550763, Compound I-226 P2X purinoceptor 3 Homo sapiens 208 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=245190 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=245190&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823214 376222165 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490978 Clc1ccc(Cn2cc(C(=O)NC3CCOCC3)c(=O)nc2Nc2ccc(Oc3ccnc(c3)C#N)cc2)cc1 InChI=1S/C29H25ClN6O4/c30-20-3-1-19(2-4-20)17-36-18-26(27(37)33-22-10-13-39-14-11-22)28(38)35-29(36)34-21-5-7-24(8-6-21)40-25-9-12-32-23(15-25)16-31/h1-9,12,15,18,22H,10-11,13-14,17H2,(H,33,37)(H,34,35,38) MUQCDCBIUZUHHG-UHFFFAOYSA-N 245191 US9550763, Compound I-227 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=245191 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=245191&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118683403 376222166 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490979 Clc1ccc(Cn2cc(C(=O)NC3CCOCC3)c(=O)nc2Nc2ccc(Oc3ccc(cn3)C#N)cc2)cc1 InChI=1S/C29H25ClN6O4/c30-21-4-1-19(2-5-21)17-36-18-25(27(37)33-23-11-13-39-14-12-23)28(38)35-29(36)34-22-6-8-24(9-7-22)40-26-10-3-20(15-31)16-32-26/h1-10,16,18,23H,11-14,17H2,(H,33,37)(H,34,35,38) BEZOAXYSMZOGOL-UHFFFAOYSA-N 245192 US9550763, Compound I-228 P2X purinoceptor 3 Homo sapiens 10.00 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=245192 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=245192&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 89745199 376222167 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490980 Clc1ccc(Cn2cc(C(=O)NC3CCOCC3)c(=O)nc2Nc2ccc(Oc3ccc(nc3)C#N)cc2)cc1 InChI=1S/C29H25ClN6O4/c30-20-3-1-19(2-4-20)17-36-18-26(27(37)33-22-11-13-39-14-12-22)28(38)35-29(36)34-21-5-8-24(9-6-21)40-25-10-7-23(15-31)32-16-25/h1-10,16,18,22H,11-14,17H2,(H,33,37)(H,34,35,38) XWBGGRPGRAPSPK-UHFFFAOYSA-N 245193 US9550763, Compound I-229 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=245193 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=245193&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118683404 376222168 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490981 Clc1ccc(Cn2cc(C(=O)NC3CCOCC3)c(=O)nc2Nc2ccc(Oc3cnc(cn3)C#N)cc2)cc1 InChI=1S/C28H24ClN7O4/c29-19-3-1-18(2-4-19)16-36-17-24(26(37)33-21-9-11-39-12-10-21)27(38)35-28(36)34-20-5-7-23(8-6-20)40-25-15-31-22(13-30)14-32-25/h1-8,14-15,17,21H,9-12,16H2,(H,33,37)(H,34,35,38) LNESVUPLIDTKTP-UHFFFAOYSA-N 245194 US9550763, Compound I-230 P2X purinoceptor 3 Homo sapiens 9.00 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=245194 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=245194&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118683405 376222169 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490982 Clc1ccc(Cn2c(=O)c(NC(=O)c3cc[nH]n3)c[nH]\c2=N/c2ccc(Oc3ccon3)cc2)cc1 InChI=1S/C24H18ClN7O4/c25-16-3-1-15(2-4-16)14-32-23(34)20(29-22(33)19-9-11-27-30-19)13-26-24(32)28-17-5-7-18(8-6-17)36-21-10-12-35-31-21/h1-13H,14H2,(H,26,28)(H,27,30)(H,29,33) RCDOAHNIXSYOQU-UHFFFAOYSA-N 245195 US9550763, Compound I-231 P2X purinoceptor 3 Homo sapiens 388 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=245195 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=245195&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823215 376222170 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490983 Cn1cc(cn1)C(=O)Nc1c[nH]\c(=N/c2ccc(Oc3ccon3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H20ClN7O4/c1-32-15-17(12-28-32)23(34)30-21-13-27-25(33(24(21)35)14-16-2-4-18(26)5-3-16)29-19-6-8-20(9-7-19)37-22-10-11-36-31-22/h2-13,15H,14H2,1H3,(H,27,29)(H,30,34) JWEZJPNWHQZDCI-UHFFFAOYSA-N 245196 US9550763, Compound I-233 P2X purinoceptor 3 Homo sapiens 236 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=245196 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=245196&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823216 376222171 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490984 Clc1ccc(Cn2c(=O)c(NC(=O)c3cn[nH]c3)c[nH]\c2=N/c2ccc(Oc3ccon3)cc2)cc1 InChI=1S/C24H18ClN7O4/c25-17-3-1-15(2-4-17)14-32-23(34)20(30-22(33)16-11-27-28-12-16)13-26-24(32)29-18-5-7-19(8-6-18)36-21-9-10-35-31-21/h1-13H,14H2,(H,26,29)(H,27,28)(H,30,33) AFQWFSJACDITEM-UHFFFAOYSA-N 245197 US9550763, Compound I-235 P2X purinoceptor 3 Homo sapiens 225 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=245197 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=245197&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823217 376222172 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490985 Clc1ccc(Cn2c(=O)c(N\C(Oc3ccccc3)=N\C#N)c[nH]\c2=N/c2ccc(Oc3ccon3)cc2)cc1 InChI=1S/C28H20ClN7O4/c29-20-8-6-19(7-9-20)17-36-26(37)24(34-28(32-18-30)40-22-4-2-1-3-5-22)16-31-27(36)33-21-10-12-23(13-11-21)39-25-14-15-38-35-25/h1-16H,17H2,(H,31,33)(H,32,34) REVHMKUXCZAXPF-UHFFFAOYSA-N 245198 US9550763, Compound I-237 P2X purinoceptor 3 Homo sapiens 219 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=245198 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=245198&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823218 376222173 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490986 CCOC(=O)\N=C(/NC)Nc1c[nH]\c(=N/c2ccc(Oc3ccon3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H24ClN7O5/c1-3-36-25(35)31-23(27-2)30-20-14-28-24(33(22(20)34)15-16-4-6-17(26)7-5-16)29-18-8-10-19(11-9-18)38-21-12-13-37-32-21/h4-14H,3,15H2,1-2H3,(H,28,29)(H2,27,30,31,35) MXNFFEUQMWCFGK-UHFFFAOYSA-N 245199 US9550763, Compound I-238 P2X purinoceptor 3 Homo sapiens 990 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=245199 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=245199&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823219 376222174 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490987 NC(=O)c1ccc(Oc2ccc(Nc3nc(=O)c(cn3Cc3ccc(Cl)cc3)C(=O)NC3CCOCC3)cc2)nc1 InChI=1S/C29H27ClN6O5/c30-20-4-1-18(2-5-20)16-36-17-24(27(38)33-22-11-13-40-14-12-22)28(39)35-29(36)34-21-6-8-23(9-7-21)41-25-10-3-19(15-32-25)26(31)37/h1-10,15,17,22H,11-14,16H2,(H2,31,37)(H,33,38)(H,34,35,39) FQVRNXKAAOXBOG-UHFFFAOYSA-N 245200 US9550763, Compound I-239 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=245200 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=245200&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118683406 376222175 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490988 NC(=O)c1cc(Oc2ccc(Nc3nc(=O)c(cn3Cc3ccc(Cl)cc3)C(=O)NC3CCOCC3)cc2)ccn1 InChI=1S/C29H27ClN6O5/c30-19-3-1-18(2-4-19)16-36-17-24(27(38)33-21-10-13-40-14-11-21)28(39)35-29(36)34-20-5-7-22(8-6-20)41-23-9-12-32-25(15-23)26(31)37/h1-9,12,15,17,21H,10-11,13-14,16H2,(H2,31,37)(H,33,38)(H,34,35,39) IWCKOAAXZCYQDP-UHFFFAOYSA-N 245201 US9550763, Compound I-240 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=245201 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=245201&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118683407 376222176 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490989 CCC(=O)N(C)C1=CN\C(=N/c2ccc(Oc3cccc(n3)C(O)=O)cc2)N(Cc2ccc(Cl)cc2)C1 InChI=1S/C27H26ClN5O4/c1-3-25(34)32(2)21-15-29-27(33(17-21)16-18-7-9-19(28)10-8-18)30-20-11-13-22(14-12-20)37-24-6-4-5-23(31-24)26(35)36/h4-15H,3,16-17H2,1-2H3,(H,29,30)(H,35,36) HHZGWDZUUJZVGQ-UHFFFAOYSA-N 245202 US9550763, Compound I-241 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=245202 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=245202&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118683408 376222177 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490990 C\C(O)=C(\C#N)C(=O)Nc1c[nH]\c(=N/c2ccc(Oc3ccon3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H19ClN6O5/c1-15(33)20(12-27)23(34)30-21-13-28-25(32(24(21)35)14-16-2-4-17(26)5-3-16)29-18-6-8-19(9-7-18)37-22-10-11-36-31-22/h2-11,13,33H,14H2,1H3,(H,28,29)(H,30,34)/b20-15+ ULWGOUQUBZBJDE-HMMYKYKNSA-N 245203 US9550763, Compound I-242 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=245203 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=245203&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823220 376222178 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490991 CN\C(Nc1c[nH]\c(=N/c2ccc(Oc3ccon3)cc2)n(Cc2ccc(Cl)cc2)c1=O)=N/C#N InChI=1S/C23H19ClN8O3/c1-26-22(28-14-25)30-19-12-27-23(32(21(19)33)13-15-2-4-16(24)5-3-15)29-17-6-8-18(9-7-17)35-20-10-11-34-31-20/h2-12H,13H2,1H3,(H,27,29)(H2,26,28,30) YLRGCKFVVFHIEK-UHFFFAOYSA-N 245204 US9550763, Compound I-243 P2X purinoceptor 3 Homo sapiens 557 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=245204 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=245204&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823221 376222179 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490992 COC(=O)[C@@H](C)Cn1c(=O)cc(Nc2ccc(Oc3cccc(F)c3)c(C)n2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C28H26ClFN4O5/c1-17(27(36)38-3)15-34-26(35)14-25(33(28(34)37)16-19-7-9-20(29)10-8-19)32-24-12-11-23(18(2)31-24)39-22-6-4-5-21(30)13-22/h4-14,17H,15-16H2,1-3H3,(H,31,32)/t17-/m0/s1 ZGBNEERKJNGPQD-KRWDZBQOSA-N 245205 US9550763, Compound I-244 P2X purinoceptor 3 Homo sapiens 646 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=245205 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=245205&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823222 376222180 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490993 C[C@@H](Cn1c(=O)cc(Nc2ccc(Oc3cccc(F)c3)c(C)n2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O InChI=1S/C27H24ClFN4O5/c1-16(26(35)36)14-33-25(34)13-24(32(27(33)37)15-18-6-8-19(28)9-7-18)31-23-11-10-22(17(2)30-23)38-21-5-3-4-20(29)12-21/h3-13,16H,14-15H2,1-2H3,(H,30,31)(H,35,36)/t16-/m0/s1 AHKLDMPLYBFODZ-INIZCTEOSA-N 245206 US9550763, Compound I-245 P2X purinoceptor 3 Homo sapiens 58.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=245206 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=245206&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823223 376222181 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490994 CCn1c(=O)cc(Nc2ccc(Oc3cccc(c3)C#N)c(C)n2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H22ClN5O3/c1-3-31-25(33)14-24(32(26(31)34)16-18-7-9-20(27)10-8-18)30-23-12-11-22(17(2)29-23)35-21-6-4-5-19(13-21)15-28/h4-14H,3,16H2,1-2H3,(H,29,30) PUNVACKBIRQMPU-UHFFFAOYSA-N 245993 US9550763, Compound I-246 P2X purinoceptor 3 Homo sapiens 71.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=245993 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=245993&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823224 376222182 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490995 CCCn1c(=O)cc(Nc2ccc(Oc3cccc(c3)C#N)c(C)n2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C27H24ClN5O3/c1-3-13-32-26(34)15-25(33(27(32)35)17-19-7-9-21(28)10-8-19)31-24-12-11-23(18(2)30-24)36-22-6-4-5-20(14-22)16-29/h4-12,14-15H,3,13,17H2,1-2H3,(H,30,31) QAFJQORZIQJINW-UHFFFAOYSA-N 246008 US9550763, Compound I-247 P2X purinoceptor 3 Homo sapiens 96.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246008 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246008&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823225 376222183 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490996 Cc1cc(ccc1Oc1ccon1)\N=c1/[nH]cc(NC(=O)C2CCOCC2)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C27H26ClN5O5/c1-17-14-21(6-7-23(17)38-24-10-13-37-32-24)30-27-29-15-22(31-25(34)19-8-11-36-12-9-19)26(35)33(27)16-18-2-4-20(28)5-3-18/h2-7,10,13-15,19H,8-9,11-12,16H2,1H3,(H,29,30)(H,31,34) GZDHXWDGPIYCSB-UHFFFAOYSA-N 246294 US9550763, Compound I-248 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246294 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246294&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823226 376222184 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490997 Cc1cc(Oc2ccc(cc2F)\N=c2/[nH]cc(NC(=O)C3CCOCC3)c(=O)n2Cc2ccc(Cl)cc2)no1 InChI=1S/C27H25ClFN5O5/c1-16-12-24(33-39-16)38-23-7-6-20(13-21(23)29)31-27-30-14-22(32-25(35)18-8-10-37-11-9-18)26(36)34(27)15-17-2-4-19(28)5-3-17/h2-7,12-14,18H,8-11,15H2,1H3,(H,30,31)(H,32,35) VATKOEKVQYYQPW-UHFFFAOYSA-N 246295 US9550763, Compound I-249 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246295 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246295&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823227 376222185 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490998 CCN\C(Nc1c[nH]\c(=N/c2ccc(Oc3ccon3)cc2)n(Cc2ccc(Cl)cc2)c1=O)=N/C#N InChI=1S/C24H21ClN8O3/c1-2-27-23(29-15-26)31-20-13-28-24(33(22(20)34)14-16-3-5-17(25)6-4-16)30-18-7-9-19(10-8-18)36-21-11-12-35-32-21/h3-13H,2,14H2,1H3,(H,28,30)(H2,27,29,31) AMPQSJYVQQGAHD-UHFFFAOYSA-N 246297 US9550763, Compound I-251 P2X purinoceptor 3 Homo sapiens 118 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246297 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246297&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823228 376222186 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490999 Clc1ccc(Cn2c(=O)c(NC(=O)c3ccccc3)c[nH]\c2=N/c2ccc(Oc3ccon3)cc2)cc1 InChI=1S/C27H20ClN5O4/c28-20-8-6-18(7-9-20)17-33-26(35)23(31-25(34)19-4-2-1-3-5-19)16-29-27(33)30-21-10-12-22(13-11-21)37-24-14-15-36-32-24/h1-16H,17H2,(H,29,30)(H,31,34) WJALGRYINPOVET-UHFFFAOYSA-N 246298 US9550763, Compound I-253 P2X purinoceptor 3 Homo sapiens 61.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246298 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246298&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823229 376222187 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491000 Clc1ccc(Cn2c(=O)c(NC(=O)c3ccccn3)c[nH]\c2=N/c2ccc(Oc3ccon3)cc2)cc1 InChI=1S/C26H19ClN6O4/c27-18-6-4-17(5-7-18)16-33-25(35)22(31-24(34)21-3-1-2-13-28-21)15-29-26(33)30-19-8-10-20(11-9-19)37-23-12-14-36-32-23/h1-15H,16H2,(H,29,30)(H,31,34) QJCCPSZFDFUKCD-UHFFFAOYSA-N 246611 US9550763, Compound I-254 P2X purinoceptor 3 Homo sapiens 868 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246611 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246611&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823230 376222188 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491001 Cc1cc(on1)C(=O)Nc1c[nH]\c(=N/c2ccc(Oc3ccon3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H19ClN6O5/c1-15-12-21(37-30-15)23(33)29-20-13-27-25(32(24(20)34)14-16-2-4-17(26)5-3-16)28-18-6-8-19(9-7-18)36-22-10-11-35-31-22/h2-13H,14H2,1H3,(H,27,28)(H,29,33) PTHNDFIMPNDCAH-UHFFFAOYSA-N 246612 US9550763, Compound I-255 P2X purinoceptor 3 Homo sapiens 147 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246612 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246612&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823231 376222189 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491002 Cc1noc(C)c1C(=O)Nc1c[nH]\c(=N/c2ccc(Oc3ccon3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H21ClN6O5/c1-15-23(16(2)38-31-15)24(34)30-21-13-28-26(33(25(21)35)14-17-3-5-18(27)6-4-17)29-19-7-9-20(10-8-19)37-22-11-12-36-32-22/h3-13H,14H2,1-2H3,(H,28,29)(H,30,34) KMYYWTLGWRKARU-UHFFFAOYSA-N 246613 US9550763, Compound I-256 P2X purinoceptor 3 Homo sapiens 14.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246613 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246613&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823232 376222190 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491003 CNC(=O)c1c[nH]\c(=N/c2ccc(Oc3nc(C)ns3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C22H19ClN6O3S/c1-13-26-22(33-28-13)32-17-9-7-16(8-10-17)27-21-25-11-18(19(30)24-2)20(31)29(21)12-14-3-5-15(23)6-4-14/h3-11H,12H2,1-2H3,(H,24,30)(H,25,27) DISLGOMMXCONNB-UHFFFAOYSA-N 246614 US9550763, Compound I-257 P2X purinoceptor 3 Homo sapiens 41.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246614 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246614&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823233 376222191 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491004 CCn1c(=O)cc(Nc2ccc(Oc3cccc(c3)C(O)=O)c(C)n2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H23ClN4O5/c1-3-30-24(32)14-23(31(26(30)35)15-17-7-9-19(27)10-8-17)29-22-12-11-21(16(2)28-22)36-20-6-4-5-18(13-20)25(33)34/h4-14H,3,15H2,1-2H3,(H,28,29)(H,33,34) BBQHDDCLLWWGTP-UHFFFAOYSA-N 246615 US9550763, Compound I-258 P2X purinoceptor 3 Homo sapiens 27.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246615 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246615&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823234 376222192 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491005 CCCn1c(=O)cc(Nc2ccc(Oc3cccc(c3)C(O)=O)c(C)n2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C27H25ClN4O5/c1-3-13-31-25(33)15-24(32(27(31)36)16-18-7-9-20(28)10-8-18)30-23-12-11-22(17(2)29-23)37-21-6-4-5-19(14-21)26(34)35/h4-12,14-15H,3,13,16H2,1-2H3,(H,29,30)(H,34,35) WNSYIEGCYLHKRF-UHFFFAOYSA-N 246616 US9550763, Compound I-259 P2X purinoceptor 3 Homo sapiens 16.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246616 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246616&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823235 376222193 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491006 CCn1c(=O)cc(Nc2ccc(Oc3cccc(c3)C(N)=O)c(C)n2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H24ClN5O4/c1-3-31-24(33)14-23(32(26(31)35)15-17-7-9-19(27)10-8-17)30-22-12-11-21(16(2)29-22)36-20-6-4-5-18(13-20)25(28)34/h4-14H,3,15H2,1-2H3,(H2,28,34)(H,29,30) LWSQKZNVUZUVGU-UHFFFAOYSA-N 246617 US9550763, Compound I-260 P2X purinoceptor 3 Homo sapiens 36.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246617 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246617&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823236 376222194 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491007 Fc1ccc(Oc2ccc(cc2)\N=c2/[nH]cc(C#N)c(=O)n2Cc2ccc(Cl)cc2)nc1 InChI=1S/C23H15ClFN5O2/c24-17-3-1-15(2-4-17)14-30-22(31)16(11-26)12-28-23(30)29-19-6-8-20(9-7-19)32-21-10-5-18(25)13-27-21/h1-10,12-13H,14H2,(H,28,29) YTIFATYJLSGHLC-UHFFFAOYSA-N 246618 US9550763, Compound I-261 P2X purinoceptor 3 Homo sapiens 498 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246618 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246618&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823237 376222195 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491008 CCc1oc2ccc(cc2c1C)\N=c1/[nH]cc(NC(=O)C2CCOCC2)c(=O)n1Cc1ccc(Cl)cn1 InChI=1S/C27H28ClN5O4/c1-3-23-16(2)21-12-19(6-7-24(21)37-23)31-27-30-14-22(32-25(34)17-8-10-36-11-9-17)26(35)33(27)15-20-5-4-18(28)13-29-20/h4-7,12-14,17H,3,8-11,15H2,1-2H3,(H,30,31)(H,32,34) ORTBGFKINWMPGE-UHFFFAOYSA-N 246619 US9550763, Compound I-262 P2X purinoceptor 3 Homo sapiens 98.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246619 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246619&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823238 376222196 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491009 Cc1nocc1C(=O)Nc1c[nH]\c(=N/c2ccc(Oc3ccon3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H19ClN6O5/c1-15-20(14-36-30-15)23(33)29-21-12-27-25(32(24(21)34)13-16-2-4-17(26)5-3-16)28-18-6-8-19(9-7-18)37-22-10-11-35-31-22/h2-12,14H,13H2,1H3,(H,27,28)(H,29,33) FAKYOQMPXGAYKU-UHFFFAOYSA-N 246620 US9550763, Compound I-264 P2X purinoceptor 3 Homo sapiens 15.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246620 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246620&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823239 376222197 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491010 Clc1ccc(Cn2c(=O)c(NC(=O)c3cccnc3)c[nH]\c2=N/c2ccc(Oc3ccon3)cc2)cc1 InChI=1S/C26H19ClN6O4/c27-19-5-3-17(4-6-19)16-33-25(35)22(31-24(34)18-2-1-12-28-14-18)15-29-26(33)30-20-7-9-21(10-8-20)37-23-11-13-36-32-23/h1-15H,16H2,(H,29,30)(H,31,34) AKBPBXMODDBNOQ-UHFFFAOYSA-N 246621 US9550763, Compound I-265 P2X purinoceptor 3 Homo sapiens 48.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246621 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246621&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823240 376222198 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491011 Clc1ccc(Cn2c(=O)c(NC(=O)c3ccncc3)c[nH]\c2=N/c2ccc(Oc3ccon3)cc2)cc1 InChI=1S/C26H19ClN6O4/c27-19-3-1-17(2-4-19)16-33-25(35)22(31-24(34)18-9-12-28-13-10-18)15-29-26(33)30-20-5-7-21(8-6-20)37-23-11-14-36-32-23/h1-15H,16H2,(H,29,30)(H,31,34) NGJAKRHYRMUSDR-UHFFFAOYSA-N 246622 US9550763, Compound I-266 P2X purinoceptor 3 Homo sapiens 68.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246622 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246622&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823241 376222199 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491012 Clc1ccc(Cn2c(=O)c(NC(=O)c3ccoc3)c[nH]\c2=N/c2ccc(Oc3ccon3)cc2)cc1 InChI=1S/C25H18ClN5O5/c26-18-3-1-16(2-4-18)14-31-24(33)21(29-23(32)17-9-11-34-15-17)13-27-25(31)28-19-5-7-20(8-6-19)36-22-10-12-35-30-22/h1-13,15H,14H2,(H,27,28)(H,29,32) YJUIBBUUMVNFAY-UHFFFAOYSA-N 246623 US9550763, Compound I-267 P2X purinoceptor 3 Homo sapiens 45.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246623 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246623&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823242 376222200 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491013 Clc1ccc(Cn2c(=O)c(NC(=O)c3cocn3)c[nH]\c2=N/c2ccc(Oc3ccon3)cc2)cc1 InChI=1S/C24H17ClN6O5/c25-16-3-1-15(2-4-16)12-31-23(33)19(29-22(32)20-13-34-14-27-20)11-26-24(31)28-17-5-7-18(8-6-17)36-21-9-10-35-30-21/h1-11,13-14H,12H2,(H,26,28)(H,29,32) CEMWQHHJRDXXQB-UHFFFAOYSA-N 246624 US9550763, Compound I-268 P2X purinoceptor 3 Homo sapiens 85.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246624 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246624&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823243 376222201 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491014 Cc1oncc1C(=O)Nc1c[nH]\c(=N/c2ccc(Oc3ccon3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H19ClN6O5/c1-15-20(12-28-37-15)23(33)30-21-13-27-25(32(24(21)34)14-16-2-4-17(26)5-3-16)29-18-6-8-19(9-7-18)36-22-10-11-35-31-22/h2-13H,14H2,1H3,(H,27,29)(H,30,33) HSCPOIBPSITUEQ-UHFFFAOYSA-N 246625 US9550763, Compound I-269 P2X purinoceptor 3 Homo sapiens 16.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246625 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246625&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823244 376222202 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491015 CC(c1ccc(Cl)cc1)n1cc(C(=O)NC2CCOCC2)c(=O)nc1Nc1ccc(Oc2cccc(F)n2)cc1 InChI=1S/C29H27ClFN5O4/c1-18(19-5-7-20(30)8-6-19)36-17-24(27(37)32-22-13-15-39-16-14-22)28(38)35-29(36)33-21-9-11-23(12-10-21)40-26-4-2-3-25(31)34-26/h2-12,17-18,22H,13-16H2,1H3,(H,32,37)(H,33,35,38) BYANULPAHKJXJP-UHFFFAOYSA-N 246626 US9550763, Compound I-270::US9550763, Compound I-358 P2X purinoceptor 3 Homo sapiens 175 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246626 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246626&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118683414 376222203 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491016 Clc1ccc(Cn2c(=O)c(c[nH]\c2=N/c2ccc(Oc3ccon3)cc2)-c2ccccn2)cc1 InChI=1S/C25H18ClN5O3/c26-18-6-4-17(5-7-18)16-31-24(32)21(22-3-1-2-13-27-22)15-28-25(31)29-19-8-10-20(11-9-19)34-23-12-14-33-30-23/h1-15H,16H2,(H,28,29) XERHLSQPGYXGDE-UHFFFAOYSA-N 246627 US9550763, Compound I-272 P2X purinoceptor 3 Homo sapiens 211 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246627 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246627&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823245 376222204 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491017 Clc1ccc(Cn2c(=O)c(c[nH]\c2=N/c2ccc(Oc3ccon3)cc2)-c2cccnc2)cc1 InChI=1S/C25H18ClN5O3/c26-19-5-3-17(4-6-19)16-31-24(32)22(18-2-1-12-27-14-18)15-28-25(31)29-20-7-9-21(10-8-20)34-23-11-13-33-30-23/h1-15H,16H2,(H,28,29) UUAUBXXCPVTDQT-UHFFFAOYSA-N 246628 US9550763, Compound I-273 P2X purinoceptor 3 Homo sapiens 201 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246628 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246628&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823246 376222205 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491018 Clc1ccc(Cn2c(=O)c(c[nH]\c2=N/c2ccc(Oc3ccon3)cc2)-c2ccncc2)cc1 InChI=1S/C25H18ClN5O3/c26-19-3-1-17(2-4-19)16-31-24(32)22(18-9-12-27-13-10-18)15-28-25(31)29-20-5-7-21(8-6-20)34-23-11-14-33-30-23/h1-15H,16H2,(H,28,29) ABXCTMPXLODLRO-UHFFFAOYSA-N 246629 US9550763, Compound I-274 P2X purinoceptor 3 Homo sapiens 356 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246629 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246629&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823247 376222206 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491019 Clc1ccc(Cn2c(=O)c(NC(=O)C3CCOCC3)c[nH]\c2=N/c2ccc(Oc3ccon3)cc2)nc1 InChI=1S/C25H23ClN6O5/c26-17-1-2-19(27-13-17)15-32-24(34)21(30-23(33)16-7-10-35-11-8-16)14-28-25(32)29-18-3-5-20(6-4-18)37-22-9-12-36-31-22/h1-6,9,12-14,16H,7-8,10-11,15H2,(H,28,29)(H,30,33) DVANVACFYHNEJA-UHFFFAOYSA-N 246630 US9550763, Compound I-275 P2X purinoceptor 3 Homo sapiens 51.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246630 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246630&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823248 376222207 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491020 CCC(=O)Nc1c[nH]\c(=N/c2ccc(Oc3ccnc(c3)C#N)cc2)n(Cc2ccc(Cl)cn2)c1=O InChI=1S/C25H20ClN7O3/c1-2-23(34)32-22-14-30-25(33(24(22)35)15-18-4-3-16(26)13-29-18)31-17-5-7-20(8-6-17)36-21-9-10-28-19(11-21)12-27/h3-11,13-14H,2,15H2,1H3,(H,30,31)(H,32,34) XMWGNXXURWELII-UHFFFAOYSA-N 246631 US9550763, Compound I-276 P2X purinoceptor 3 Homo sapiens 165 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246631 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246631&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823249 376222208 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491021 CCC(=O)Nc1c[nH]\c(=N/c2ccc(Oc3ccnc(c3)C(N)=O)cc2)n(Cc2ccc(Cl)cn2)c1=O InChI=1S/C25H22ClN7O4/c1-2-22(34)32-21-13-30-25(33(24(21)36)14-17-4-3-15(26)12-29-17)31-16-5-7-18(8-6-16)37-19-9-10-28-20(11-19)23(27)35/h3-13H,2,14H2,1H3,(H2,27,35)(H,30,31)(H,32,34) DNLNWHBQMQWBGT-UHFFFAOYSA-N 246632 US9550763, Compound I-277 P2X purinoceptor 3 Homo sapiens 172 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246632 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246632&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823250 376222209 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491022 Cc1cnc(o1)-c1c[nH]\c(=N/c2ccc(Oc3cccc(n3)C#N)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C27H19ClN6O3/c1-17-14-30-25(36-17)23-15-31-27(34(26(23)35)16-18-5-7-19(28)8-6-18)33-20-9-11-22(12-10-20)37-24-4-2-3-21(13-29)32-24/h2-12,14-15H,16H2,1H3,(H,31,33) CCIJBWDCRCUSLI-UHFFFAOYSA-N 246633 US9550763, Compound I-278 P2X purinoceptor 3 Homo sapiens 20.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246633 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246633&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823251 376222210 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491023 Fc1cccc(Oc2ccc(Nc3nc(=O)c(cn3Cc3ccccc3)C(=O)NC3CCOCC3)cc2)n1 InChI=1S/C28H26FN5O4/c29-24-7-4-8-25(32-24)38-22-11-9-20(10-12-22)31-28-33-27(36)23(26(35)30-21-13-15-37-16-14-21)18-34(28)17-19-5-2-1-3-6-19/h1-12,18,21H,13-17H2,(H,30,35)(H,31,33,36) JSBNPUPNWYOYBR-UHFFFAOYSA-N 246634 US9550763, Compound I-280 P2X purinoceptor 3 Homo sapiens 139 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246634 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246634&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118683419 376222211 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491024 Fc1ccc(Cn2cc(C(=O)NC3CCOCC3)c(=O)nc2Nc2ccc(Oc3cccc(F)n3)cc2)cc1 InChI=1S/C28H25F2N5O4/c29-19-6-4-18(5-7-19)16-35-17-23(26(36)31-21-12-14-38-15-13-21)27(37)34-28(35)32-20-8-10-22(11-9-20)39-25-3-1-2-24(30)33-25/h1-11,17,21H,12-16H2,(H,31,36)(H,32,34,37) WATUBWWPJFPOGJ-UHFFFAOYSA-N 246635 US9550763, Compound I-281 P2X purinoceptor 3 Homo sapiens 41.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246635 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246635&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118683420 376222212 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491025 Cc1ccc(Cn2cc(C(=O)NC3CCOCC3)c(=O)nc2Nc2ccc(Oc3cccc(F)n3)cc2)cc1 InChI=1S/C29H28FN5O4/c1-19-5-7-20(8-6-19)17-35-18-24(27(36)31-22-13-15-38-16-14-22)28(37)34-29(35)32-21-9-11-23(12-10-21)39-26-4-2-3-25(30)33-26/h2-12,18,22H,13-17H2,1H3,(H,31,36)(H,32,34,37) ZPUVVTDTGUCHOL-UHFFFAOYSA-N 246636 US9550763, Compound I-282 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246636 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246636&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118683422 376222213 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491026 Fc1cccc(Cn2cc(C(=O)NC3CCOCC3)c(=O)nc2Nc2ccc(Oc3cccc(F)n3)cc2)c1 InChI=1S/C28H25F2N5O4/c29-19-4-1-3-18(15-19)16-35-17-23(26(36)31-21-11-13-38-14-12-21)27(37)34-28(35)32-20-7-9-22(10-8-20)39-25-6-2-5-24(30)33-25/h1-10,15,17,21H,11-14,16H2,(H,31,36)(H,32,34,37) PQIIIEKIWXHLNS-UHFFFAOYSA-N 246637 US9550763, Compound I-283 P2X purinoceptor 3 Homo sapiens 226 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246637 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246637&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118683421 376222214 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491027 Fc1cccc(Oc2ccc(Nc3nc(=O)c(cn3Cc3ccccc3F)C(=O)NC3CCOCC3)cc2)n1 InChI=1S/C28H25F2N5O4/c29-23-5-2-1-4-18(23)16-35-17-22(26(36)31-20-12-14-38-15-13-20)27(37)34-28(35)32-19-8-10-21(11-9-19)39-25-7-3-6-24(30)33-25/h1-11,17,20H,12-16H2,(H,31,36)(H,32,34,37) LORCYRYAWQHGOH-UHFFFAOYSA-N 246638 US9550763, Compound I-284 P2X purinoceptor 3 Homo sapiens 42.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246638 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246638&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118683423 376222215 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491028 CCC(=O)Nc1c[nH]\c(=N/c2ccc(Oc3ccnc(c3)C(=O)OC)cc2)n(Cc2ccc(Cl)cn2)c1=O InChI=1S/C26H23ClN6O5/c1-3-23(34)32-22-14-30-26(33(24(22)35)15-18-5-4-16(27)13-29-18)31-17-6-8-19(9-7-17)38-20-10-11-28-21(12-20)25(36)37-2/h4-14H,3,15H2,1-2H3,(H,30,31)(H,32,34) XPIIUVKXCXQJBF-UHFFFAOYSA-N 246639 US9550763, Compound I-287 P2X purinoceptor 3 Homo sapiens 356 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246639 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246639&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823252 376222216 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491029 Cc1cnc(o1)-c1c[nH]\c(=N/c2ccc(Oc3cccc(n3)C(N)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C27H21ClN6O4/c1-16-13-30-25(37-16)21-14-31-27(34(26(21)36)15-17-5-7-18(28)8-6-17)32-19-9-11-20(12-10-19)38-23-4-2-3-22(33-23)24(29)35/h2-14H,15H2,1H3,(H2,29,35)(H,31,32) HTHQSIHZHIQODU-UHFFFAOYSA-N 246640 US9550763, Compound I-288 P2X purinoceptor 3 Homo sapiens 15.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246640 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246640&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823253 376222217 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491030 CCC(=O)Nc1c[nH]\c(=N/c2ccc(Oc3ccnc(c3)C(O)=O)cc2)n(Cc2ccc(Cl)cn2)c1=O InChI=1S/C25H21ClN6O5/c1-2-22(33)31-21-13-29-25(32(23(21)34)14-17-4-3-15(26)12-28-17)30-16-5-7-18(8-6-16)37-19-9-10-27-20(11-19)24(35)36/h3-13H,2,14H2,1H3,(H,29,30)(H,31,33)(H,35,36) DFFIZLDLAQNEEJ-UHFFFAOYSA-N 246641 US9550763, Compound I-289 P2X purinoceptor 3 Homo sapiens 24.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246641 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246641&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823254 376222218 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491031 Cc1cnc(o1)-c1c[nH]\c(=N/c2ccc(Oc3cccc(n3)C(O)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C27H20ClN5O5/c1-16-13-29-24(37-16)21-14-30-27(33(25(21)34)15-17-5-7-18(28)8-6-17)31-19-9-11-20(12-10-19)38-23-4-2-3-22(32-23)26(35)36/h2-14H,15H2,1H3,(H,30,31)(H,35,36) VUGVNVZKDFCRLD-UHFFFAOYSA-N 246642 US9550763, Compound I-290 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246642 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246642&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823255 376222219 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491032 Cc1cnc(o1)-c1c[nH]\c(=N/c2ccc(Oc3ccon3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H18ClN5O4/c1-15-12-26-22(33-15)20-13-27-24(30(23(20)31)14-16-2-4-17(25)5-3-16)28-18-6-8-19(9-7-18)34-21-10-11-32-29-21/h2-13H,14H2,1H3,(H,27,28) UVVUMAFOIGADID-UHFFFAOYSA-N 246643 US9550763, Compound I-294 P2X purinoceptor 3 Homo sapiens 84.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246643 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246643&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823256 376222220 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491033 Fc1cccc(Oc2ccc(Nc3nc(=O)c(cn3Cc3ccccn3)C(=O)NC3CCOCC3)cc2)n1 InChI=1S/C27H25FN6O4/c28-23-5-3-6-24(32-23)38-21-9-7-18(8-10-21)31-27-33-26(36)22(25(35)30-19-11-14-37-15-12-19)17-34(27)16-20-4-1-2-13-29-20/h1-10,13,17,19H,11-12,14-16H2,(H,30,35)(H,31,33,36) XVBRDGDJEBQFFO-UHFFFAOYSA-N 246644 US9550763, Compound I-295 P2X purinoceptor 3 Homo sapiens 618 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246644 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246644&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 89745515 376222221 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491136 CC(C)c1c[nH]\c(=N/c2ccc(Oc3cncc(c3)C(O)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H23ClN4O4/c1-16(2)23-14-29-26(31(24(23)32)15-17-3-5-19(27)6-4-17)30-20-7-9-21(10-8-20)35-22-11-18(25(33)34)12-28-13-22/h3-14,16H,15H2,1-2H3,(H,29,30)(H,33,34) MZKZBEDRBZWMNW-UHFFFAOYSA-N 246747 US9550763, Compound I-401 P2X purinoceptor 3 Homo sapiens 12.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246747 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246747&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823318 376222323 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491137 Fc1ccc(Cn2cc(C(=O)NC3CCOCC3)c(=O)nc2Nc2ccc(Oc3cccc(F)n3)cc2)c(F)c1 InChI=1S/C28H24F3N5O4/c29-18-5-4-17(23(30)14-18)15-36-16-22(26(37)32-20-10-12-39-13-11-20)27(38)35-28(36)33-19-6-8-21(9-7-19)40-25-3-1-2-24(31)34-25/h1-9,14,16,20H,10-13,15H2,(H,32,37)(H,33,35,38) MZASAQIJPSBAMG-UHFFFAOYSA-N 246748 US9550763, Compound I-402 P2X purinoceptor 3 Homo sapiens 9.00 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246748 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246748&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118683493 376222324 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491138 COc1cn(Cc2ccc(Cl)cc2)c(Nc2ccc(Oc3cccc(n3)C(N)=O)cc2)nc1=O InChI=1S/C24H20ClN5O4/c1-33-20-14-30(13-15-5-7-16(25)8-6-15)24(29-23(20)32)27-17-9-11-18(12-10-17)34-21-4-2-3-19(28-21)22(26)31/h2-12,14H,13H2,1H3,(H2,26,31)(H,27,29,32) YWUMLASPPJZWRH-UHFFFAOYSA-N 246749 US9550763, Compound I-403 P2X purinoceptor 3 Homo sapiens 243 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246749 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246749&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 89745499 376222325 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491139 COc1cn(Cc2ccc(Cl)cc2)c(Nc2ccc(Oc3cccc(n3)C(O)=O)cc2)nc1=O InChI=1S/C24H19ClN4O5/c1-33-20-14-29(13-15-5-7-16(25)8-6-15)24(28-22(20)30)26-17-9-11-18(12-10-17)34-21-4-2-3-19(27-21)23(31)32/h2-12,14H,13H2,1H3,(H,31,32)(H,26,28,30) VKVZHUPSEUEPBW-UHFFFAOYSA-N 246750 US9550763, Compound I-404 P2X purinoceptor 3 Homo sapiens 102 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246750 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246750&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 89745500 376222326 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491140 Cc1nc(Nc2cc(=O)n(CC(F)(F)C(O)=O)c(=O)n2Cc2ccc(Cl)cc2)ccc1Oc1ccc(F)cn1 InChI=1S/C25H19ClF3N5O5/c1-14-18(39-21-9-6-17(27)11-30-21)7-8-19(31-14)32-20-10-22(35)34(13-25(28,29)23(36)37)24(38)33(20)12-15-2-4-16(26)5-3-15/h2-11H,12-13H2,1H3,(H,31,32)(H,36,37) DUWGVJZERXMRCE-UHFFFAOYSA-N 246751 US9550763, Compound I-405 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246751 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246751&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823319 376222327 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491141 Fc1cccc(Oc2ccc(cc2)\N=c2/[nH]cc(C(=O)NCC#C)c(=O)n2Cc2ccc(Cl)cc2)n1 InChI=1S/C26H19ClFN5O3/c1-2-14-29-24(34)21-15-30-26(33(25(21)35)16-17-6-8-18(27)9-7-17)31-19-10-12-20(13-11-19)36-23-5-3-4-22(28)32-23/h1,3-13,15H,14,16H2,(H,29,34)(H,30,31) SDZZNWHHEIEIQT-UHFFFAOYSA-N 246752 US9550763, Compound I-406 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246752 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246752&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823320 376222328 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491142 Fc1cccc(Oc2ccc(cc2)\N=c2/[nH]cc(C(=O)NCC3CC3)c(=O)n2Cc2ccc(Cl)cc2)n1 InChI=1S/C27H23ClFN5O3/c28-19-8-6-18(7-9-19)16-34-26(36)22(25(35)30-14-17-4-5-17)15-31-27(34)32-20-10-12-21(13-11-20)37-24-3-1-2-23(29)33-24/h1-3,6-13,15,17H,4-5,14,16H2,(H,30,35)(H,31,32) QYYUTUUXJAYIOH-UHFFFAOYSA-N 246753 US9550763, Compound I-407 P2X purinoceptor 3 Homo sapiens 68.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246753 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246753&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823321 376222329 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491143 Clc1ccc(Cn2c(=O)c(c[nH]\c2=N/c2ccc(Oc3cccc(n3)C#N)cc2)-c2ccccc2)cc1 InChI=1S/C29H20ClN5O2/c30-22-11-9-20(10-12-22)19-35-28(36)26(21-5-2-1-3-6-21)18-32-29(35)34-23-13-15-25(16-14-23)37-27-8-4-7-24(17-31)33-27/h1-16,18H,19H2,(H,32,34) RRBWRTNHYQTPCT-UHFFFAOYSA-N 246754 US9550763, Compound I-408 P2X purinoceptor 3 Homo sapiens 407 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246754 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246754&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823322 376222330 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491144 CC(C)c1c[nH]\c(=N/c2ccc(Oc3ccnc(c3)C(O)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H23ClN4O4/c1-16(2)22-14-29-26(31(24(22)32)15-17-3-5-18(27)6-4-17)30-19-7-9-20(10-8-19)35-21-11-12-28-23(13-21)25(33)34/h3-14,16H,15H2,1-2H3,(H,29,30)(H,33,34) OOPFIANQXLDQAB-UHFFFAOYSA-N 246755 US9550763, Compound I-409 P2X purinoceptor 3 Homo sapiens 24.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246755 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246755&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823323 376222331 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491145 CCOC(=O)c1cnc(Oc2ccc(cc2)\N=c2/[nH]cc(C(C)C)c(=O)n2Cc2ccc(Cl)cc2)s1 InChI=1S/C26H25ClN4O4S/c1-4-34-24(33)22-14-29-26(36-22)35-20-11-9-19(10-12-20)30-25-28-13-21(16(2)3)23(32)31(25)15-17-5-7-18(27)8-6-17/h5-14,16H,4,15H2,1-3H3,(H,28,30) DLGHBGUJODLNMV-UHFFFAOYSA-N 246756 US9550763, Compound I-410 P2X purinoceptor 3 Homo sapiens 626 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246756 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246756&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823324 376222332 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491146 CCC(=O)Nc1c[nH]\c(=N/c2ccc(Oc3ccc(nn3)C(F)(F)F)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H20ClF3N6O3/c1-2-21(36)32-19-13-30-24(35(23(19)37)14-15-3-5-16(26)6-4-15)31-17-7-9-18(10-8-17)38-22-12-11-20(33-34-22)25(27,28)29/h3-13H,2,14H2,1H3,(H,30,31)(H,32,36) XLLIPSINKQFWDH-UHFFFAOYSA-N 246757 US9550763, Compound I-411 P2X purinoceptor 3 Homo sapiens 10.00 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246757 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246757&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823325 376222333 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491147 CC(C)c1c[nH]\c(=N/c2ccc(Oc3ncc(s3)C(O)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H21ClN4O4S/c1-14(2)19-11-26-23(29(21(19)30)13-15-3-5-16(25)6-4-15)28-17-7-9-18(10-8-17)33-24-27-12-20(34-24)22(31)32/h3-12,14H,13H2,1-2H3,(H,26,28)(H,31,32) DWPUOLQWGOAOES-UHFFFAOYSA-N 246758 US9550763, Compound I-412 P2X purinoceptor 3 Homo sapiens 9.00 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246758 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246758&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823326 376222334 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491148 Cc1c[nH]c2cc(Nc3ncc(NC(=O)C4CCOCC4)c(=O)n3Cc3ccc(Cl)cc3)ccc12 InChI=1S/C26H26ClN5O3/c1-16-13-28-22-12-20(6-7-21(16)22)30-26-29-14-23(31-24(33)18-8-10-35-11-9-18)25(34)32(26)15-17-2-4-19(27)5-3-17/h2-7,12-14,18,28H,8-11,15H2,1H3,(H,29,30)(H,31,33) QJMHLDVIDSOLGE-UHFFFAOYSA-N 246759 US9550763, Compound I-413 P2X purinoceptor 3 Homo sapiens 897 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246759 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246759&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118686094 376222335 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491149 Cc1c[nH]c2ccc(Nc3ncc(NC(=O)C4CCOCC4)c(=O)n3Cc3ccc(Cl)cc3)cc12 InChI=1S/C26H26ClN5O3/c1-16-13-28-22-7-6-20(12-21(16)22)30-26-29-14-23(31-24(33)18-8-10-35-11-9-18)25(34)32(26)15-17-2-4-19(27)5-3-17/h2-7,12-14,18,28H,8-11,15H2,1H3,(H,29,30)(H,31,33) RTZIXRSQGCNLFF-UHFFFAOYSA-N 246760 US9550763, Compound I-414 P2X purinoceptor 3 Homo sapiens 392 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246760 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246760&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118685890 376222336 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491150 CCc1c[nH]c2cc(Nc3ncc(NC(=O)C4CCOCC4)c(=O)n3Cc3ccc(Cl)cc3)ccc12 InChI=1S/C27H28ClN5O3/c1-2-18-14-29-23-13-21(7-8-22(18)23)31-27-30-15-24(32-25(34)19-9-11-36-12-10-19)26(35)33(27)16-17-3-5-20(28)6-4-17/h3-8,13-15,19,29H,2,9-12,16H2,1H3,(H,30,31)(H,32,34) WJKNUTCIBMNHPN-UHFFFAOYSA-N 246761 US9550763, Compound I-416 P2X purinoceptor 3 Homo sapiens 406 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246761 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246761&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118685892 376222337 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491151 OCCCNC(=O)c1cn(Cc2ccc(Cl)cc2)c(Nc2ccc(Oc3cccc(F)n3)cc2)nc1=O InChI=1S/C26H23ClFN5O4/c27-18-7-5-17(6-8-18)15-33-16-21(24(35)29-13-2-14-34)25(36)32-26(33)30-19-9-11-20(12-10-19)37-23-4-1-3-22(28)31-23/h1,3-12,16,34H,2,13-15H2,(H,29,35)(H,30,32,36) JPDWPTQOYRGWBC-UHFFFAOYSA-N 246762 US9550763, Compound I-418 P2X purinoceptor 3 Homo sapiens 45.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246762 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246762&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118683497 376222338 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491152 Fc1cccc(Oc2ccc(Nc3nc(=O)c(cn3Cc3ccc(Cl)cc3)C(=O)NCc3ccoc3)cc2)n1 InChI=1S/C28H21ClFN5O4/c29-20-6-4-18(5-7-20)15-35-16-23(26(36)31-14-19-12-13-38-17-19)27(37)34-28(35)32-21-8-10-22(11-9-21)39-25-3-1-2-24(30)33-25/h1-13,16-17H,14-15H2,(H,31,36)(H,32,34,37) SCZDAYJEKCREPG-UHFFFAOYSA-N 246763 US9550763, Compound I-419 P2X purinoceptor 3 Homo sapiens 55.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246763 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246763&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118683499 376222339 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491153 Cc1cc(CNC(=O)c2cn(Cc3ccc(Cl)cc3)c(Nc3ccc(Oc4cccc(F)n4)cc3)nc2=O)no1 InChI=1S/C28H22ClFN6O4/c1-17-13-21(35-40-17)14-31-26(37)23-16-36(15-18-5-7-19(29)8-6-18)28(34-27(23)38)32-20-9-11-22(12-10-20)39-25-4-2-3-24(30)33-25/h2-13,16H,14-15H2,1H3,(H,31,37)(H,32,34,38) FSCFMSWEPWCVAF-UHFFFAOYSA-N 246764 US9550763, Compound I-420 P2X purinoceptor 3 Homo sapiens 88.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246764 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246764&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118683501 376222340 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491154 Fc1cccc(Oc2ccc(Nc3nc(=O)c(cn3Cc3ccc(Cl)cc3)C(=O)Nc3cc[nH]n3)cc2)n1 InChI=1S/C26H19ClFN7O3/c27-17-6-4-16(5-7-17)14-35-15-20(24(36)32-22-12-13-29-34-22)25(37)33-26(35)30-18-8-10-19(11-9-18)38-23-3-1-2-21(28)31-23/h1-13,15H,14H2,(H,30,33,37)(H2,29,32,34,36) YYAKKFLFDKYUQC-UHFFFAOYSA-N 246765 US9550763, Compound I-421 P2X purinoceptor 3 Homo sapiens 17.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246765 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246765&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118683498 376222341 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491155 OC(=O)c1cccc(Oc2ccc(cc2)\N=c2/[nH]cc(-c3ccccc3)c(=O)n2Cc2ccc(Cl)cc2)n1 InChI=1S/C29H21ClN4O4/c30-21-11-9-19(10-12-21)18-34-27(35)24(20-5-2-1-3-6-20)17-31-29(34)32-22-13-15-23(16-14-22)38-26-8-4-7-25(33-26)28(36)37/h1-17H,18H2,(H,31,32)(H,36,37) NTTWOXXUDANSBU-UHFFFAOYSA-N 246766 US9550763, Compound I-422 P2X purinoceptor 3 Homo sapiens 3.00 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246766 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246766&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823327 376222342 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491156 NNC(=O)c1c[nH]\c(=N/c2ccc(Oc3ccon3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C21H17ClN6O4/c22-14-3-1-13(2-4-14)12-28-20(30)17(19(29)26-23)11-24-21(28)25-15-5-7-16(8-6-15)32-18-9-10-31-27-18/h1-11H,12,23H2,(H,24,25)(H,26,29) HIRLTTBKVGGEPN-UHFFFAOYSA-N 246767 US9550763, Compound I-423 P2X purinoceptor 3 Homo sapiens 81.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246767 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246767&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823328 376222343 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491157 Clc1ccc(Cn2c(=O)c(c[nH]\c2=N/c2ccc(Oc3ccon3)cc2)C(=O)NCC#N)cc1 InChI=1S/C23H17ClN6O4/c24-16-3-1-15(2-4-16)14-30-22(32)19(21(31)26-11-10-25)13-27-23(30)28-17-5-7-18(8-6-17)34-20-9-12-33-29-20/h1-9,12-13H,11,14H2,(H,26,31)(H,27,28) WTSVLFFHYPLJGD-UHFFFAOYSA-N 246768 US9550763, Compound I-425 P2X purinoceptor 3 Homo sapiens 21.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246768 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246768&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823329 376222344 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491034 CN(C)C(=O)CNC(=O)c1cn(Cc2ccc(Cl)cc2)c(Nc2ccc(Oc3ccc(F)cn3)cc2)nc1=O InChI=1S/C27H24ClFN6O4/c1-34(2)24(36)14-31-25(37)22-16-35(15-17-3-5-18(28)6-4-17)27(33-26(22)38)32-20-8-10-21(11-9-20)39-23-12-7-19(29)13-30-23/h3-13,16H,14-15H2,1-2H3,(H,31,37)(H,32,33,38) CGIRIFUGMJRJLO-UHFFFAOYSA-N 246645 US9550763, Compound I-297 P2X purinoceptor 3 Homo sapiens 21.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246645 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246645&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118683426 376222222 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491035 CN(C)C(=O)CNC(=O)c1cn(Cc2ccc(Cl)cc2)c(Nc2ccc(Oc3ccc(C)nn3)cc2)nc1=O InChI=1S/C27H26ClN7O4/c1-17-4-13-23(33-32-17)39-21-11-9-20(10-12-21)30-27-31-26(38)22(25(37)29-14-24(36)34(2)3)16-35(27)15-18-5-7-19(28)8-6-18/h4-13,16H,14-15H2,1-3H3,(H,29,37)(H,30,31,38) BHMZWHYEKQZKGJ-UHFFFAOYSA-N 246646 US9550763, Compound I-298 P2X purinoceptor 3 Homo sapiens 23.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246646 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246646&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 89745511 376222223 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491036 CN(C)C(=O)CNC(=O)c1cn(Cc2ccc(Cl)cc2)c(Nc2ccc(Oc3cccc(F)n3)cc2)nc1=O InChI=1S/C27H24ClFN6O4/c1-34(2)24(36)14-30-25(37)21-16-35(15-17-6-8-18(28)9-7-17)27(33-26(21)38)31-19-10-12-20(13-11-19)39-23-5-3-4-22(29)32-23/h3-13,16H,14-15H2,1-2H3,(H,30,37)(H,31,33,38) XYLYWUSIJPGRAQ-UHFFFAOYSA-N 246647 US9550763, Compound I-299 P2X purinoceptor 3 Homo sapiens 18.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246647 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246647&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118683427 376222224 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491037 FC(F)c1nc2ccc(Nc3ncc(NC(=O)C4CCOCC4)c(=O)n3Cc3ccc(Cl)cc3)cc2s1 InChI=1S/C25H22ClF2N5O3S/c26-16-3-1-14(2-4-16)13-33-24(35)19(31-22(34)15-7-9-36-10-8-15)12-29-25(33)30-17-5-6-18-20(11-17)37-23(32-18)21(27)28/h1-6,11-12,15,21H,7-10,13H2,(H,29,30)(H,31,34) NFFXAKPGPYBQIS-UHFFFAOYSA-N 246648 US9550763, Compound I-300 P2X purinoceptor 3 Homo sapiens 15.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246648 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246648&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118686082 376222225 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491038 CCCn1c(=O)c(F)c(Nc2ccc(Oc3cccc(n3)C#N)c(C)n2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H22ClFN6O3/c1-3-13-33-25(35)23(28)24(34(26(33)36)15-17-7-9-18(27)10-8-17)32-21-12-11-20(16(2)30-21)37-22-6-4-5-19(14-29)31-22/h4-12H,3,13,15H2,1-2H3,(H,30,32) WYRXVWVYGARHOU-UHFFFAOYSA-N 246649 US9550763, Compound I-301 P2X purinoceptor 3 Homo sapiens 163 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246649 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246649&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823257 376222226 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491039 CCCn1c(=O)c(F)c(Nc2ccc(Oc3cccc(c3)C(O)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C27H23ClFN3O5/c1-2-14-31-25(33)23(29)24(32(27(31)36)16-17-6-8-19(28)9-7-17)30-20-10-12-21(13-11-20)37-22-5-3-4-18(15-22)26(34)35/h3-13,15,30H,2,14,16H2,1H3,(H,34,35) NRXBQTYMNDTJJN-UHFFFAOYSA-N 246650 US9550763, Compound I-303 P2X purinoceptor 3 Homo sapiens 109 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246650 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246650&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823258 376222227 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491040 Cc1cc(Oc2ccc(cc2C)\N=c2/[nH]cc(NC(=O)C3CCOCC3)c(=O)n2Cc2ccc(Cl)cc2)no1 InChI=1S/C28H28ClN5O5/c1-17-13-22(7-8-24(17)38-25-14-18(2)39-33-25)31-28-30-15-23(32-26(35)20-9-11-37-12-10-20)27(36)34(28)16-19-3-5-21(29)6-4-19/h3-8,13-15,20H,9-12,16H2,1-2H3,(H,30,31)(H,32,35) BBRLUZSCBFGFNY-UHFFFAOYSA-N 246651 US9550763, Compound I-304 P2X purinoceptor 3 Homo sapiens 12.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246651 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246651&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823259 376222228 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491041 CCC(=O)Nc1c[nH]\c(=N/c2ccc(Oc3ccc(nn3)C(=O)OC)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H23ClN6O5/c1-3-22(34)30-21-14-28-26(33(24(21)35)15-16-4-6-17(27)7-5-16)29-18-8-10-19(11-9-18)38-23-13-12-20(31-32-23)25(36)37-2/h4-14H,3,15H2,1-2H3,(H,28,29)(H,30,34) STMAWWIUHWSSQF-UHFFFAOYSA-N 246652 US9550763, Compound I-305 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246652 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246652&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823260 376222229 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491042 CCC(=O)Nc1c[nH]\c(=N/c2ccc(Oc3ccc(nn3)C#N)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H20ClN7O3/c1-2-22(34)30-21-14-28-25(33(24(21)35)15-16-3-5-17(26)6-4-16)29-18-7-10-20(11-8-18)36-23-12-9-19(13-27)31-32-23/h3-12,14H,2,15H2,1H3,(H,28,29)(H,30,34) QSQDEASNIITIOD-UHFFFAOYSA-N 246653 US9550763, Compound I-306 P2X purinoceptor 3 Homo sapiens 19.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246653 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246653&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823261 376222230 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491043 Clc1ccc(Cn2c(=O)c(Nc3ccon3)c[nH]\c2=N/c2ccc(Oc3ccon3)cc2)cc1 InChI=1S/C23H17ClN6O4/c24-16-3-1-15(2-4-16)14-30-22(31)19(27-20-9-11-32-28-20)13-25-23(30)26-17-5-7-18(8-6-17)34-21-10-12-33-29-21/h1-13H,14H2,(H,25,26)(H,27,28) OVDRIVHUGYZLSZ-UHFFFAOYSA-N 246654 US9550763, Compound I-307 P2X purinoceptor 3 Homo sapiens 21.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246654 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246654&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823262 376222231 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491044 Cc1ccc(Oc2ccc(cc2)\N=c2/[nH]cc(NC(=O)[C@H]3C[C@H](O)C3)c(=O)n2Cc2ccc(Cl)cc2)nn1 246655 US9550763, Compound I-308 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246655 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246655&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823263 376222232 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491045 CCC(=O)Nc1c[nH]\c(=N/c2ccc(Oc3ccc(nn3)C(N)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H22ClN7O4/c1-2-21(34)30-20-13-28-25(33(24(20)36)14-15-3-5-16(26)6-4-15)29-17-7-9-18(10-8-17)37-22-12-11-19(23(27)35)31-32-22/h3-13H,2,14H2,1H3,(H2,27,35)(H,28,29)(H,30,34) ZMYNGMZYUVEBGJ-UHFFFAOYSA-N 246656 US9550763, Compound I-309 P2X purinoceptor 3 Homo sapiens 9.00 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246656 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246656&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823264 376222233 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491046 Cc1noc(n1)-c1c[nH]\c(=N/c2ccc(Oc3cccc(n3)C#N)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H18ClN7O3/c1-16-30-24(37-33-16)22-14-29-26(34(25(22)35)15-17-5-7-18(27)8-6-17)32-19-9-11-21(12-10-19)36-23-4-2-3-20(13-28)31-23/h2-12,14H,15H2,1H3,(H,29,32) RQQINQKWPRXMTG-UHFFFAOYSA-N 246657 US9550763, Compound I-310 P2X purinoceptor 3 Homo sapiens 16.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246657 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246657&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823265 376222234 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491047 CCOC(=O)c1cnc(Oc2ccc(cc2)\N=c2/[nH]cc(-c3nc(C)no3)c(=O)n2Cc2ccc(Cl)cc2)s1 InChI=1S/C26H21ClN6O5S/c1-3-36-24(35)21-13-29-26(39-21)37-19-10-8-18(9-11-19)31-25-28-12-20(22-30-15(2)32-38-22)23(34)33(25)14-16-4-6-17(27)7-5-16/h4-13H,3,14H2,1-2H3,(H,28,31) JJXDVCZFURHGQG-UHFFFAOYSA-N 246658 US9550763, Compound I-311 P2X purinoceptor 3 Homo sapiens 31.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246658 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246658&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823266 376222235 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491048 COC(=O)c1ccc(Oc2ccc(cc2)\N=c2/[nH]cc(-c3nc(C)no3)c(=O)n2Cc2ccc(Cl)cc2)nn1 InChI=1S/C26H20ClN7O5/c1-15-29-23(39-33-15)20-13-28-26(34(24(20)35)14-16-3-5-17(27)6-4-16)30-18-7-9-19(10-8-18)38-22-12-11-21(31-32-22)25(36)37-2/h3-13H,14H2,1-2H3,(H,28,30) DZJRABAKORRDBK-UHFFFAOYSA-N 246659 US9550763, Compound I-312 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246659 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246659&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823267 376222236 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491049 Cc1noc(n1)-c1c[nH]\c(=N/c2ccc(Oc3cccc(n3)C(O)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H19ClN6O5/c1-15-29-23(38-32-15)20-13-28-26(33(24(20)34)14-16-5-7-17(27)8-6-16)30-18-9-11-19(12-10-18)37-22-4-2-3-21(31-22)25(35)36/h2-13H,14H2,1H3,(H,28,30)(H,35,36) JYROAHOYWZLFDF-UHFFFAOYSA-N 246660 US9550763, Compound I-313 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246660 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246660&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823268 376222237 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491050 Cc1noc(n1)-c1c[nH]\c(=N/c2ccc(Oc3ncc(s3)C(O)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H17ClN6O5S/c1-13-28-20(36-30-13)18-10-26-23(31(21(18)32)12-14-2-4-15(25)5-3-14)29-16-6-8-17(9-7-16)35-24-27-11-19(37-24)22(33)34/h2-11H,12H2,1H3,(H,26,29)(H,33,34) FRJMUVXZCYTJKX-UHFFFAOYSA-N 246661 US9550763, Compound I-314 P2X purinoceptor 3 Homo sapiens 10.00 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246661 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246661&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823269 376222238 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491051 Cc1noc(n1)-c1c[nH]\c(=N/c2ccc(Oc3ccc(nn3)C(N)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H19ClN8O4/c1-14-29-23(38-33-14)19-12-28-25(34(24(19)36)13-15-2-4-16(26)5-3-15)30-17-6-8-18(9-7-17)37-21-11-10-20(22(27)35)31-32-21/h2-12H,13H2,1H3,(H2,27,35)(H,28,30) XWVFFNWZVKLVAQ-UHFFFAOYSA-N 246662 US9550763, Compound I-315 P2X purinoceptor 3 Homo sapiens 10.00 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246662 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246662&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823270 376222239 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491052 Cc1noc(n1)-c1c[nH]\c(=N/c2ccc(Oc3cccc(n3)C(N)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H20ClN7O4/c1-15-30-24(38-33-15)20-13-29-26(34(25(20)36)14-16-5-7-17(27)8-6-16)31-18-9-11-19(12-10-18)37-22-4-2-3-21(32-22)23(28)35/h2-13H,14H2,1H3,(H2,28,35)(H,29,31) VIHFSCJQNDBGKI-UHFFFAOYSA-N 246663 US9550763, Compound I-316 P2X purinoceptor 3 Homo sapiens 13.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246663 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246663&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823271 376222240 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491053 Cc1noc(n1)-c1c[nH]\c(=N/c2ccc(Oc3ccc(nn3)C(O)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H18ClN7O5/c1-14-28-22(38-32-14)19-12-27-25(33(23(19)34)13-15-2-4-16(26)5-3-15)29-17-6-8-18(9-7-17)37-21-11-10-20(24(35)36)30-31-21/h2-12H,13H2,1H3,(H,27,29)(H,35,36) RTNUDDGXTIPQHG-UHFFFAOYSA-N 246664 US9550763, Compound I-317 P2X purinoceptor 3 Homo sapiens 13.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246664 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246664&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823272 376222241 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491054 Fc1ccc(Oc2ccc(cc2)\N=c2/[nH]cc(Nc3ccon3)c(=O)n2Cc2ccc(Cl)cc2)nc1 InChI=1S/C25H18ClFN6O3/c26-17-3-1-16(2-4-17)15-33-24(34)21(31-22-11-12-35-32-22)14-29-25(33)30-19-6-8-20(9-7-19)36-23-10-5-18(27)13-28-23/h1-14H,15H2,(H,29,30)(H,31,32) CWRUVMXLIFNYRQ-UHFFFAOYSA-N 246665 US9550763, Compound I-318 P2X purinoceptor 3 Homo sapiens 27.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246665 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246665&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823273 376222242 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491055 Clc1ccc(Cn2c(=O)c(Nc3ccon3)c[nH]\c2=N/c2ccc(Oc3cccc(n3)C#N)cc2)cc1 InChI=1S/C26H18ClN7O3/c27-18-6-4-17(5-7-18)16-34-25(35)22(32-23-12-13-36-33-23)15-29-26(34)31-19-8-10-21(11-9-19)37-24-3-1-2-20(14-28)30-24/h1-13,15H,16H2,(H,29,31)(H,32,33) AJCWYQNSACUCGT-UHFFFAOYSA-N 246666 US9550763, Compound I-319 P2X purinoceptor 3 Homo sapiens 19.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246666 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246666&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823274 376222243 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491056 COC(=O)c1cc(Oc2ccc(cc2)\N=c2/[nH]cc(Nc3ccon3)c(=O)n2Cc2ccc(Cl)cc2)ccn1 InChI=1S/C27H21ClN6O5/c1-37-26(36)22-14-21(10-12-29-22)39-20-8-6-19(7-9-20)31-27-30-15-23(32-24-11-13-38-33-24)25(35)34(27)16-17-2-4-18(28)5-3-17/h2-15H,16H2,1H3,(H,30,31)(H,32,33) KKQPEAFDNJRVSN-UHFFFAOYSA-N 246667 US9550763, Compound I-320 P2X purinoceptor 3 Homo sapiens 19.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246667 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246667&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823275 376222244 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491057 CC(C)c1c[nH]\c(=N/c2ccc(Oc3cccc(n3)C#N)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H22ClN5O2/c1-17(2)23-15-29-26(32(25(23)33)16-18-6-8-19(27)9-7-18)31-20-10-12-22(13-11-20)34-24-5-3-4-21(14-28)30-24/h3-13,15,17H,16H2,1-2H3,(H,29,31) IEZUAZSVQFHFLL-UHFFFAOYSA-N 246668 US9550763, Compound I-321 P2X purinoceptor 3 Homo sapiens 150 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246668 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246668&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823276 376222245 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491058 COCCn1c(=O)cc(Nc2ccc(Oc3cccc(n3)C#N)c(C)n2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H23ClN6O4/c1-17-21(37-24-5-3-4-20(15-28)30-24)10-11-22(29-17)31-23-14-25(34)32(12-13-36-2)26(35)33(23)16-18-6-8-19(27)9-7-18/h3-11,14H,12-13,16H2,1-2H3,(H,29,31) DZKKDFHSPWXYKY-UHFFFAOYSA-N 246669 US9550763, Compound I-322 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246669 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246669&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823277 376222246 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491059 COC(=O)[C@H](C)[C@H](C)n1c(=O)cc(Nc2ccc(Oc3ccc(F)cn3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C28H26ClFN4O5/c1-17(27(36)38-3)18(2)34-26(35)14-24(33(28(34)37)16-19-4-6-20(29)7-5-19)32-22-9-11-23(12-10-22)39-25-13-8-21(30)15-31-25/h4-15,17-18,32H,16H2,1-3H3/t17-,18+/m1/s1 NEVJWIAMHHGRSK-MSOLQXFVSA-N 246670 US9550763, Compound I-323 P2X purinoceptor 3 Homo sapiens 26.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246670 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246670&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823278 376222247 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491060 COCCn1c(=O)cc(Nc2ccc(Oc3cccc(n3)C(O)=O)c(C)n2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H24ClN5O6/c1-16-20(38-23-5-3-4-19(29-23)25(34)35)10-11-21(28-16)30-22-14-24(33)31(12-13-37-2)26(36)32(22)15-17-6-8-18(27)9-7-17/h3-11,14H,12-13,15H2,1-2H3,(H,28,30)(H,34,35) LGAFWXFBYCATIG-UHFFFAOYSA-N 246671 US9550763, Compound I-324 P2X purinoceptor 3 Homo sapiens 14.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246671 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246671&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823279 376222248 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491061 C[C@H]([C@H](C)n1c(=O)cc(Nc2ccc(Oc3ccc(F)cn3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O InChI=1S/C27H24ClFN4O5/c1-16(26(35)36)17(2)33-25(34)13-23(32(27(33)37)15-18-3-5-19(28)6-4-18)31-21-8-10-22(11-9-21)38-24-12-7-20(29)14-30-24/h3-14,16-17,31H,15H2,1-2H3,(H,35,36)/t16-,17+/m1/s1 TYYGTJWQWWOPLO-SJORKVTESA-N 246672 US9550763, Compound I-325 P2X purinoceptor 3 Homo sapiens 11.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246672 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246672&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823280 376222249 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491062 CCn1c(=O)cc(Nc2ccc3nc(sc3c2)C(F)F)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C21H17ClF2N4O2S/c1-2-27-18(29)10-17(28(21(27)30)11-12-3-5-13(22)6-4-12)25-14-7-8-15-16(9-14)31-20(26-15)19(23)24/h3-10,19,25H,2,11H2,1H3 FCYAHIZDGAXFIE-UHFFFAOYSA-N 246673 US9550763, Compound I-326 P2X purinoceptor 3 Homo sapiens 328 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246673&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823281 376222250 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491063 Cc1nnc(o1)-c1c[nH]\c(=N/c2ccc(Oc3cccc(n3)C#N)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H18ClN7O3/c1-16-32-33-24(36-16)22-14-29-26(34(25(22)35)15-17-5-7-18(27)8-6-17)31-19-9-11-21(12-10-19)37-23-4-2-3-20(13-28)30-23/h2-12,14H,15H2,1H3,(H,29,31) WBCLMELVYMQDTK-UHFFFAOYSA-N 246674 US9550763, Compound I-327 P2X purinoceptor 3 Homo sapiens 34.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246674 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246674&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823282 376222251 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491064 Cc1nnc(o1)-c1c[nH]\c(=N/c2ccc(Oc3cccc(n3)C(O)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H19ClN6O5/c1-15-31-32-23(37-15)20-13-28-26(33(24(20)34)14-16-5-7-17(27)8-6-16)29-18-9-11-19(12-10-18)38-22-4-2-3-21(30-22)25(35)36/h2-13H,14H2,1H3,(H,28,29)(H,35,36) WYJQCDSNVHCUPO-UHFFFAOYSA-N 246675 US9550763, Compound I-328 P2X purinoceptor 3 Homo sapiens 11.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246675 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246675&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823283 376222252 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491065 Cc1nnc(o1)-c1c[nH]\c(=N/c2ccc(Oc3cccc(n3)C(N)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H20ClN7O4/c1-15-32-33-24(37-15)20-13-29-26(34(25(20)36)14-16-5-7-17(27)8-6-16)30-18-9-11-19(12-10-18)38-22-4-2-3-21(31-22)23(28)35/h2-13H,14H2,1H3,(H2,28,35)(H,29,30) RMSLADHUAOOLIB-UHFFFAOYSA-N 246676 US9550763, Compound I-329 P2X purinoceptor 3 Homo sapiens 20.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246676 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246676&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823284 376222253 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491066 CCC(=O)Nc1c[nH]\c(=N/c2ccc(Oc3cccc(CCC(=O)OC)c3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C30H29ClN4O5/c1-3-27(36)34-26-18-32-30(35(29(26)38)19-21-7-10-22(31)11-8-21)33-23-12-14-24(15-13-23)40-25-6-4-5-20(17-25)9-16-28(37)39-2/h4-8,10-15,17-18H,3,9,16,19H2,1-2H3,(H,32,33)(H,34,36) UPQWSCJUQSVGCW-UHFFFAOYSA-N 246677 US9550763, Compound I-330 P2X purinoceptor 3 Homo sapiens 366 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246677 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246677&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823285 376222254 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491067 CCC(=O)Nc1c[nH]\c(=N/c2ccc(Oc3cccc(CC(=O)OC)c3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C29H27ClN4O5/c1-3-26(35)33-25-17-31-29(34(28(25)37)18-19-7-9-21(30)10-8-19)32-22-11-13-23(14-12-22)39-24-6-4-5-20(15-24)16-27(36)38-2/h4-15,17H,3,16,18H2,1-2H3,(H,31,32)(H,33,35) HIDBFNLRRNHHSK-UHFFFAOYSA-N 246678 US9550763, Compound I-331 P2X purinoceptor 3 Homo sapiens 309 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246678 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246678&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823286 376222255 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491068 Clc1ccc(Cn2c(=O)c(c[nH]\c2=N/c2ccc(Oc3cccc(n3)C#N)cc2)N2CCCC2=O)cc1 InChI=1S/C27H21ClN6O3/c28-19-8-6-18(7-9-19)17-34-26(36)23(33-14-2-5-25(33)35)16-30-27(34)32-20-10-12-22(13-11-20)37-24-4-1-3-21(15-29)31-24/h1,3-4,6-13,16H,2,5,14,17H2,(H,30,32) XAIZJFLUERKUPH-UHFFFAOYSA-N 246679 US9550763, Compound I-332 P2X purinoceptor 3 Homo sapiens 179 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246679 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246679&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823287 376222256 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491069 Fc1cccc(Oc2ccc(cc2)\N=c2/[nH]cc(N3CCCC3=O)c(=O)n2Cc2ccc(Cl)cc2)n1 InChI=1S/C26H21ClFN5O3/c27-18-8-6-17(7-9-18)16-33-25(35)21(32-14-2-5-24(32)34)15-29-26(33)30-19-10-12-20(13-11-19)36-23-4-1-3-22(28)31-23/h1,3-4,6-13,15H,2,5,14,16H2,(H,29,30) DTLSKNWIJWNIDJ-UHFFFAOYSA-N 246680 US9550763, Compound I-333 P2X purinoceptor 3 Homo sapiens 149 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246680 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246680&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823288 376222257 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491070 CSc1cccc(Oc2ccc(cc2)\N=c2/[nH]cc(N3CCCC3=O)c(=O)n2Cc2ccc(Cl)cc2)n1 InChI=1S/C27H24ClN5O3S/c1-37-24-5-2-4-23(31-24)36-21-13-11-20(12-14-21)30-27-29-16-22(32-15-3-6-25(32)34)26(35)33(27)17-18-7-9-19(28)10-8-18/h2,4-5,7-14,16H,3,6,15,17H2,1H3,(H,29,30) YSQJHPOMXKAROI-UHFFFAOYSA-N 246681 US9550763, Compound I-334 P2X purinoceptor 3 Homo sapiens 838 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246681 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246681&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823289 376222258 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491071 NC(=O)c1cccc(Oc2ccc(cc2)\N=c2/[nH]cc(N3CCCC3=O)c(=O)n2Cc2ccc(Cl)cc2)n1 InChI=1S/C27H23ClN6O4/c28-18-8-6-17(7-9-18)16-34-26(37)22(33-14-2-5-24(33)35)15-30-27(34)31-19-10-12-20(13-11-19)38-23-4-1-3-21(32-23)25(29)36/h1,3-4,6-13,15H,2,5,14,16H2,(H2,29,36)(H,30,31) BTHJMSKIEWSDJY-UHFFFAOYSA-N 246682 US9550763, Compound I-335 P2X purinoceptor 3 Homo sapiens 227 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246682 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246682&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823290 376222259 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491072 OC(=O)c1cccc(Oc2ccc(cc2)\N=c2/[nH]cc(N3CCCC3=O)c(=O)n2Cc2ccc(Cl)cc2)n1 InChI=1S/C27H22ClN5O5/c28-18-8-6-17(7-9-18)16-33-25(35)22(32-14-2-5-24(32)34)15-29-27(33)30-19-10-12-20(13-11-19)38-23-4-1-3-21(31-23)26(36)37/h1,3-4,6-13,15H,2,5,14,16H2,(H,29,30)(H,36,37) WWOQNHRGNQRORQ-UHFFFAOYSA-N 246683 US9550763, Compound I-336 P2X purinoceptor 3 Homo sapiens 41.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246683 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246683&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823291 376222260 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491073 CCC(=O)Nc1c[nH]\c(=N/c2ccc(Oc3cccc(CCC(O)=O)c3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C29H27ClN4O5/c1-2-26(35)33-25-17-31-29(34(28(25)38)18-20-6-9-21(30)10-7-20)32-22-11-13-23(14-12-22)39-24-5-3-4-19(16-24)8-15-27(36)37/h3-7,9-14,16-17H,2,8,15,18H2,1H3,(H,31,32)(H,33,35)(H,36,37) MHBYFLVAZYLVFF-UHFFFAOYSA-N 246684 US9550763, Compound I-337 P2X purinoceptor 3 Homo sapiens 76.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246684 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246684&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823292 376222261 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491074 COC(=O)[C@H](C)[C@H](C)n1c(=O)cc(Nc2ccc(Oc3ccc(F)nc3)c(C)n2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C28H27ClFN5O5/c1-16(27(37)39-4)18(3)35-26(36)13-25(34(28(35)38)15-19-5-7-20(29)8-6-19)33-24-12-10-22(17(2)32-24)40-21-9-11-23(30)31-14-21/h5-14,16,18H,15H2,1-4H3,(H,32,33)/t16-,18+/m1/s1 UFDYGZAUWPTLNR-AEFFLSMTSA-N 246685 US9550763, Compound I-338 P2X purinoceptor 3 Homo sapiens 9.00 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246685 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246685&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823293 376222262 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491075 C[C@H]([C@H](C)n1c(=O)cc(Nc2ccc(Oc3ccc(F)nc3)c(C)n2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O InChI=1S/C27H25ClFN5O5/c1-15(26(36)37)17(3)34-25(35)12-24(33(27(34)38)14-18-4-6-19(28)7-5-18)32-23-11-9-21(16(2)31-23)39-20-8-10-22(29)30-13-20/h4-13,15,17H,14H2,1-3H3,(H,31,32)(H,36,37)/t15-,17+/m1/s1 JQUUBLKDYDVSCQ-WBVHZDCISA-N 246686 US9550763, Compound I-339 P2X purinoceptor 3 Homo sapiens 9.00 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246686 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246686&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823294 376222263 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491076 CC(C)n1c(=O)cc(Nc2ccc(Oc3cccc(c3)C#N)c(C)n2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C27H24ClN5O3/c1-17(2)33-26(34)14-25(32(27(33)35)16-19-7-9-21(28)10-8-19)31-24-12-11-23(18(3)30-24)36-22-6-4-5-20(13-22)15-29/h4-14,17H,16H2,1-3H3,(H,30,31) FGNDFAVEMOVFJM-UHFFFAOYSA-N 246687 US9550763, Compound I-340 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246687 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246687&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823295 376222264 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491077 CC(C)n1c(=O)cc(Nc2ccc(Oc3cccc(n3)C(O)=O)c(C)n2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H24ClN5O5/c1-15(2)32-24(33)13-22(31(26(32)36)14-17-7-9-18(27)10-8-17)30-21-12-11-20(16(3)28-21)37-23-6-4-5-19(29-23)25(34)35/h4-13,15H,14H2,1-3H3,(H,28,30)(H,34,35) YOFQGJGSAIBXMM-UHFFFAOYSA-N 246688 US9550763, Compound I-341 P2X purinoceptor 3 Homo sapiens 10.00 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246688 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246688&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823296 376222265 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491078 COCCn1c(=O)cc(Nc2ccc(Oc3ccc(F)nc3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H22ClFN4O4/c1-34-13-12-30-24(32)14-23(31(25(30)33)16-17-2-4-18(26)5-3-17)29-19-6-8-20(9-7-19)35-21-10-11-22(27)28-15-21/h2-11,14-15,29H,12-13,16H2,1H3 HHVNNQYVVZDVEW-UHFFFAOYSA-N 246689 US9550763, Compound I-342 P2X purinoceptor 3 Homo sapiens 10.00 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246689 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246689&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823297 376222266 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491079 CC(=O)OCC(=O)NNC(=O)c1c[nH]\c(=N/c2ccc(Oc3ccon3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H21ClN6O7/c1-15(33)37-14-21(34)29-30-23(35)20-12-27-25(32(24(20)36)13-16-2-4-17(26)5-3-16)28-18-6-8-19(9-7-18)39-22-10-11-38-31-22/h2-12H,13-14H2,1H3,(H,27,28)(H,29,34)(H,30,35) BYHKSZDVTXEULR-UHFFFAOYSA-N 246690 US9550763, Compound I-343 P2X purinoceptor 3 Homo sapiens 84.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246690 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246690&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823298 376222267 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491080 Clc1ccc(Cn2c(=O)c(c[nH]\c2=N/c2ccc(Oc3ccon3)cc2)C(=O)NCC#C)cc1 InChI=1S/C24H18ClN5O4/c1-2-12-26-22(31)20-14-27-24(30(23(20)32)15-16-3-5-17(25)6-4-16)28-18-7-9-19(10-8-18)34-21-11-13-33-29-21/h1,3-11,13-14H,12,15H2,(H,26,31)(H,27,28) ILVFICZNLKUUTF-UHFFFAOYSA-N 246691 US9550763, Compound I-344 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246691 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246691&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823299 376222268 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491081 Cc1noc(n1)-c1c[nH]\c(=N/c2ccc(Oc3ccon3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H17ClN6O4/c1-14-26-21(34-28-14)19-12-25-23(30(22(19)31)13-15-2-4-16(24)5-3-15)27-17-6-8-18(9-7-17)33-20-10-11-32-29-20/h2-12H,13H2,1H3,(H,25,27) WPZRSADSZPGMBT-UHFFFAOYSA-N 246692 US9550763, Compound I-345 P2X purinoceptor 3 Homo sapiens 38.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246692 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246692&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823300 376222269 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491082 CN(C)C(=O)c1c[nH]\c(=N/c2ccc(Oc3ccon3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H20ClN5O4/c1-28(2)21(30)19-13-25-23(29(22(19)31)14-15-3-5-16(24)6-4-15)26-17-7-9-18(10-8-17)33-20-11-12-32-27-20/h3-13H,14H2,1-2H3,(H,25,26) GNGVNSGSXICJQI-UHFFFAOYSA-N 246693 US9550763, Compound I-346 P2X purinoceptor 3 Homo sapiens 346 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246693 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246693&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823301 376222270 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491083 CC(=O)NNC(=O)c1c[nH]\c(=N/c2ccc(Oc3ccon3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H19ClN6O5/c1-14(31)27-28-21(32)19-12-25-23(30(22(19)33)13-15-2-4-16(24)5-3-15)26-17-6-8-18(9-7-17)35-20-10-11-34-29-20/h2-12H,13H2,1H3,(H,25,26)(H,27,31)(H,28,32) IKXPFZRKLFTMNK-UHFFFAOYSA-N 246694 US9550763, Compound I-347 P2X purinoceptor 3 Homo sapiens 152 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246694 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246694&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823302 376222271 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491084 CC(=O)OCc1nnc(o1)-c1c[nH]\c(=N/c2ccc(Oc3ccon3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H19ClN6O6/c1-15(33)35-14-22-29-30-23(38-22)20-12-27-25(32(24(20)34)13-16-2-4-17(26)5-3-16)28-18-6-8-19(9-7-18)37-21-10-11-36-31-21/h2-12H,13-14H2,1H3,(H,27,28) RSUWNIACRVWFJF-UHFFFAOYSA-N 246695 US9550763, Compound I-348 P2X purinoceptor 3 Homo sapiens 76.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246695 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246695&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823303 376222272 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491085 Cc1nnc(o1)-c1c[nH]\c(=N/c2ccc(Oc3ccon3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H17ClN6O4/c1-14-27-28-21(33-14)19-12-25-23(30(22(19)31)13-15-2-4-16(24)5-3-15)26-17-6-8-18(9-7-17)34-20-10-11-32-29-20/h2-12H,13H2,1H3,(H,25,26) JIHHMBOJVBWARR-UHFFFAOYSA-N 246696 US9550763, Compound I-349 P2X purinoceptor 3 Homo sapiens 73.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246696 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246696&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823304 376222273 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491086 COc1cn(Cc2ccc(Cl)cc2)c(Nc2ccc(Oc3cccc(n3)C#N)cc2)nc1=O InChI=1S/C24H18ClN5O3/c1-32-21-15-30(14-16-5-7-17(25)8-6-16)24(29-23(21)31)28-18-9-11-20(12-10-18)33-22-4-2-3-19(13-26)27-22/h2-12,15H,14H2,1H3,(H,28,29,31) CWKXUNLGCKJICY-UHFFFAOYSA-N 246697 US9550763, Compound I-350 P2X purinoceptor 3 Homo sapiens 405 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246697 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246697&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 89745227 376222274 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491087 COc1cn(Cc2ccc(Cl)cc2)c(Nc2ccc(Oc3cccc(F)n3)cc2)nc1=O InChI=1S/C23H18ClFN4O3/c1-31-19-14-29(13-15-5-7-16(24)8-6-15)23(28-22(19)30)26-17-9-11-18(12-10-17)32-21-4-2-3-20(25)27-21/h2-12,14H,13H2,1H3,(H,26,28,30) QHGOGNRAIXWMNW-UHFFFAOYSA-N 246698 US9550763, Compound I-351 P2X purinoceptor 3 Homo sapiens 98.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246698 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246698&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 89745243 376222275 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491088 CC(c1ccc(F)cc1)n1cc(C(=O)NC2CCOCC2)c(=O)nc1Nc1ccc(Oc2cccc(F)n2)cc1 InChI=1S/C29H27F2N5O4/c1-18(19-5-7-20(30)8-6-19)36-17-24(27(37)32-22-13-15-39-16-14-22)28(38)35-29(36)33-21-9-11-23(12-10-21)40-26-4-2-3-25(31)34-26/h2-12,17-18,22H,13-16H2,1H3,(H,32,37)(H,33,35,38) BEBWZMQABNUTJK-UHFFFAOYSA-N 246699 US9550763, Compound I-352 P2X purinoceptor 3 Homo sapiens 369 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246699 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246699&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118683452 376222276 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491089 CC(C)c1c[nH]\c(=N/c2ccc(Oc3cccc(n3)C(O)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H23ClN4O4/c1-16(2)21-14-28-26(31(24(21)32)15-17-6-8-18(27)9-7-17)29-19-10-12-20(13-11-19)35-23-5-3-4-22(30-23)25(33)34/h3-14,16H,15H2,1-2H3,(H,28,29)(H,33,34) KXDLPUROVMZVNS-UHFFFAOYSA-N 246700 US9550763, Compound I-353 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246700 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246700&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823305 376222277 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491090 OC(=O)c1cc(Oc2ccc(cc2)\N=c2/[nH]cc(Nc3ccon3)c(=O)n2Cc2ccc(Cl)cc2)ccn1 InChI=1S/C26H19ClN6O5/c27-17-3-1-16(2-4-17)15-33-24(34)22(31-23-10-12-37-32-23)14-29-26(33)30-18-5-7-19(8-6-18)38-20-9-11-28-21(13-20)25(35)36/h1-14H,15H2,(H,29,30)(H,31,32)(H,35,36) WHKSSYUCSVYMQY-UHFFFAOYSA-N 246701 US9550763, Compound I-354 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246701 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246701&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823306 376222278 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491091 CCC(=O)Nc1c[nH]\c(=N/c2ccc(Oc3cccc(CC(O)=O)c3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C28H25ClN4O5/c1-2-25(34)32-24-16-30-28(33(27(24)37)17-18-6-8-20(29)9-7-18)31-21-10-12-22(13-11-21)38-23-5-3-4-19(14-23)15-26(35)36/h3-14,16H,2,15,17H2,1H3,(H,30,31)(H,32,34)(H,35,36) LWRABTKPUNWBKO-UHFFFAOYSA-N 246702 US9550763, Compound I-355 P2X purinoceptor 3 Homo sapiens 53.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246702 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246702&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823307 376222279 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491092 Clc1ccc(CN2[C@H](Nc3ccc(Oc4ccon4)cc3)NC=C(N3CCCC3=O)C2=O)cc1 InChI=1S/C24H22ClN5O4/c25-17-5-3-16(4-6-17)15-30-23(32)20(29-12-1-2-22(29)31)14-26-24(30)27-18-7-9-19(10-8-18)34-21-11-13-33-28-21/h3-11,13-14,24,26-27H,1-2,12,15H2/t24-/m0/s1 OERBYVDEMFISQV-DEOSSOPVSA-N 246703 US9550763, Compound I-356 P2X purinoceptor 3 Homo sapiens 212 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246703 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246703&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118683454 376222280 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491093 Cc1ccccc1Cn1cc(C(=O)NC2CCOCC2)c(=O)nc1Nc1ccc(Oc2cccc(F)n2)cc1 InChI=1S/C29H28FN5O4/c1-19-5-2-3-6-20(19)17-35-18-24(27(36)31-22-13-15-38-16-14-22)28(37)34-29(35)32-21-9-11-23(12-10-21)39-26-8-4-7-25(30)33-26/h2-12,18,22H,13-17H2,1H3,(H,31,36)(H,32,34,37) MLHCFXUDMBBSGZ-UHFFFAOYSA-N 246704 US9550763, Compound I-357 P2X purinoceptor 3 Homo sapiens 781 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246704 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246704&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118683455 376222281 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491094 CC(c1ccc(Cl)cc1)n1cc(C(=O)NC2CCOCC2)c(=O)nc1Nc1ccc(Oc2cccc(F)n2)cc1 InChI=1S/C29H27ClFN5O4/c1-18(19-5-7-20(30)8-6-19)36-17-24(27(37)32-22-13-15-39-16-14-22)28(38)35-29(36)33-21-9-11-23(12-10-21)40-26-4-2-3-25(31)34-26/h2-12,17-18,22H,13-16H2,1H3,(H,32,37)(H,33,35,38) BYANULPAHKJXJP-UHFFFAOYSA-N 246626 US9550763, Compound I-270::US9550763, Compound I-358 P2X purinoceptor 3 Homo sapiens 23.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246626 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246626&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118683414 376222203 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491095 FC(F)c1nc2ccc(Nc3nc(=O)c(cn3Cc3ccc(Cl)cc3)C(=O)NC3CCOCC3)cc2s1 InChI=1S/C25H22ClF2N5O3S/c26-15-3-1-14(2-4-15)12-33-13-18(22(34)29-16-7-9-36-10-8-16)23(35)32-25(33)30-17-5-6-19-20(11-17)37-24(31-19)21(27)28/h1-6,11,13,16,21H,7-10,12H2,(H,29,34)(H,30,32,35) ARRUKYIEPKSRNI-UHFFFAOYSA-N 246706 US9550763, Compound I-359 P2X purinoceptor 3 Homo sapiens 57.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246706 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246706&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118683456 376222282 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491096 COC(=O)CCCn1c(=O)cc(Nc2ccc(Oc3ccc(F)cn3)c(C)n2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C27H25ClFN5O5/c1-17-21(39-24-12-9-20(29)15-30-24)10-11-22(31-17)32-23-14-25(35)33(13-3-4-26(36)38-2)27(37)34(23)16-18-5-7-19(28)8-6-18/h5-12,14-15H,3-4,13,16H2,1-2H3,(H,31,32) XZXWJYZEORFDQM-UHFFFAOYSA-N 246707 US9550763, Compound I-360 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246707 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246707&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823308 376222283 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491097 Cc1nc(Nc2cc(=O)n(CCCC(O)=O)c(=O)n2Cc2ccc(Cl)cc2)ccc1Oc1ccc(F)cn1 InChI=1S/C26H23ClFN5O5/c1-16-20(38-23-11-8-19(28)14-29-23)9-10-21(30-16)31-22-13-24(34)32(12-2-3-25(35)36)26(37)33(22)15-17-4-6-18(27)7-5-17/h4-11,13-14H,2-3,12,15H2,1H3,(H,30,31)(H,35,36) AMZWWHYCSDORBA-UHFFFAOYSA-N 246708 US9550763, Compound I-361 P2X purinoceptor 3 Homo sapiens 32.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246708 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246708&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823309 376222284 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491098 COC(=O)[C@@H](C)Cn1c(=O)cc(Nc2ccc(Oc3ccc(F)cn3)c(C)n2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C27H25ClFN5O5/c1-16(26(36)38-3)14-34-25(35)12-23(33(27(34)37)15-18-4-6-19(28)7-5-18)32-22-10-9-21(17(2)31-22)39-24-11-8-20(29)13-30-24/h4-13,16H,14-15H2,1-3H3,(H,31,32)/t16-/m0/s1 HPBYATUVAXGAJD-INIZCTEOSA-N 246709 US9550763, Compound I-362 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246709 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246709&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823310 376222285 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491158 Fc1ccc(Oc2ccc(cc2)\N=c2/[nH]cc(C(=O)NCC#N)c(=O)n2Cc2ccc(Cl)cc2)nc1 InChI=1S/C25H18ClFN6O3/c26-17-3-1-16(2-4-17)15-33-24(35)21(23(34)29-12-11-28)14-31-25(33)32-19-6-8-20(9-7-19)36-22-10-5-18(27)13-30-22/h1-10,13-14H,12,15H2,(H,29,34)(H,31,32) AOIFMYMWKOWEQU-UHFFFAOYSA-N 246769 US9550763, Compound I-426 P2X purinoceptor 3 Homo sapiens 15.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246769 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246769&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823330 376222345 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491159 Fc1ccc(Oc2ccc(cc2)\N=c2/[nH]cc(C(=O)NCC#C)c(=O)n2Cc2ccc(Cl)cc2)nc1 InChI=1S/C26H19ClFN5O3/c1-2-13-29-24(34)22-15-31-26(33(25(22)35)16-17-3-5-18(27)6-4-17)32-20-8-10-21(11-9-20)36-23-12-7-19(28)14-30-23/h1,3-12,14-15H,13,16H2,(H,29,34)(H,31,32) CMMYLDYJZLUVKJ-UHFFFAOYSA-N 246770 US9550763, Compound I-427 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246770 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246770&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823331 376222346 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491160 OC(=O)COc1cn(Cc2ccc(Cl)cc2)c(Nc2ccc(Oc3cccc(F)n3)cc2)nc1=O InChI=1S/C24H18ClFN4O5/c25-16-6-4-15(5-7-16)12-30-13-19(34-14-22(31)32)23(33)29-24(30)27-17-8-10-18(11-9-17)35-21-3-1-2-20(26)28-21/h1-11,13H,12,14H2,(H,31,32)(H,27,29,33) MKXDGEGPGNQVEV-UHFFFAOYSA-N 246771 US9550763, Compound I-428 P2X purinoceptor 3 Homo sapiens 289 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246771 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246771&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 89745099 376222347 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491161 CCOc1cn(Cc2ccc(Cl)cc2)c(Nc2ccc(Oc3cccc(n3)C#N)cc2)nc1=O InChI=1S/C25H20ClN5O3/c1-2-33-22-16-31(15-17-6-8-18(26)9-7-17)25(30-24(22)32)29-19-10-12-21(13-11-19)34-23-5-3-4-20(14-27)28-23/h3-13,16H,2,15H2,1H3,(H,29,30,32) NFKZWUHBSMZDDW-UHFFFAOYSA-N 246772 US9550763, Compound I-429 P2X purinoceptor 3 Homo sapiens 441 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246772 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246772&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 89745507 376222348 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491162 CNC(=O)CNC(=O)c1cn(Cc2ccc(Cl)cc2)c(Nc2ccc(Oc3cccc(F)n3)cc2)nc1=O InChI=1S/C26H22ClFN6O4/c1-29-22(35)13-30-24(36)20-15-34(14-16-5-7-17(27)8-6-16)26(33-25(20)37)31-18-9-11-19(12-10-18)38-23-4-2-3-21(28)32-23/h2-12,15H,13-14H2,1H3,(H,29,35)(H,30,36)(H,31,33,37) HUAYFBRPTSTMNY-UHFFFAOYSA-N 246773 US9550763, Compound I-430 P2X purinoceptor 3 Homo sapiens 83.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246773 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246773&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118683505 376222349 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491163 NC(=O)CNC(=O)c1cn(Cc2ccc(Cl)cc2)c(Nc2ccc(Oc3cccc(F)n3)cc2)nc1=O InChI=1S/C25H20ClFN6O4/c26-16-6-4-15(5-7-16)13-33-14-19(23(35)29-12-21(28)34)24(36)32-25(33)30-17-8-10-18(11-9-17)37-22-3-1-2-20(27)31-22/h1-11,14H,12-13H2,(H2,28,34)(H,29,35)(H,30,32,36) SIMCMBSJZMNNCV-UHFFFAOYSA-N 246774 US9550763, Compound I-431 P2X purinoceptor 3 Homo sapiens 44.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246774 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246774&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118683506 376222350 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491164 CCC(=O)Nc1c[nH]\c(=N/c2ccc(Oc3cc(C)c(Cl)nn3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H22Cl2N6O3/c1-3-21(34)30-20-13-28-25(33(24(20)35)14-16-4-6-17(26)7-5-16)29-18-8-10-19(11-9-18)36-22-12-15(2)23(27)32-31-22/h4-13H,3,14H2,1-2H3,(H,28,29)(H,30,34) RNXMTLWJPLBHCX-UHFFFAOYSA-N 246775 US9550763, Compound I-432 P2X purinoceptor 3 Homo sapiens 12.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246775 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246775&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823332 376222351 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491165 CCC(=O)Nc1c[nH]\c(=N/c2ccc(Oc3cc(C)cnn3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H23ClN6O3/c1-3-22(33)30-21-14-27-25(32(24(21)34)15-17-4-6-18(26)7-5-17)29-19-8-10-20(11-9-19)35-23-12-16(2)13-28-31-23/h4-14H,3,15H2,1-2H3,(H,27,29)(H,30,33) FSXUMURVFDPDTR-UHFFFAOYSA-N 246776 US9550763, Compound I-433 P2X purinoceptor 3 Homo sapiens 99.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246776 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246776&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823333 376222352 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491166 CCCc1c[nH]\c(=N/c2ccc(Oc3cccc(n3)C#N)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H22ClN5O2/c1-2-4-19-16-29-26(32(25(19)33)17-18-7-9-20(27)10-8-18)31-21-11-13-23(14-12-21)34-24-6-3-5-22(15-28)30-24/h3,5-14,16H,2,4,17H2,1H3,(H,29,31) GBFYQZNMNDLTJT-UHFFFAOYSA-N 246777 US9550763, Compound I-434 P2X purinoceptor 3 Homo sapiens 193 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246777 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246777&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823334 376222353 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491167 FC(F)(F)c1ccc(Oc2ccc(cc2)\N=c2/[nH]cc(NC(=O)C3CCOCC3)c(=O)n2Cc2ccc(Cl)cc2)nn1 InChI=1S/C28H24ClF3N6O4/c29-19-3-1-17(2-4-19)16-38-26(40)22(35-25(39)18-11-13-41-14-12-18)15-33-27(38)34-20-5-7-21(8-6-20)42-24-10-9-23(36-37-24)28(30,31)32/h1-10,15,18H,11-14,16H2,(H,33,34)(H,35,39) RBWPIUBNPISUFX-UHFFFAOYSA-N 246778 US9550763, Compound I-435 P2X purinoceptor 3 Homo sapiens 3.00 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246778 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246778&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823335 376222354 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491168 CCCc1c[nH]\c(=N/c2ccc(Oc3cccc(n3)C(O)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H23ClN4O4/c1-2-4-18-15-28-26(31(24(18)32)16-17-7-9-19(27)10-8-17)29-20-11-13-21(14-12-20)35-23-6-3-5-22(30-23)25(33)34/h3,5-15H,2,4,16H2,1H3,(H,28,29)(H,33,34) FBBZFFRGCUJODO-UHFFFAOYSA-N 246779 US9550763, Compound I-436 P2X purinoceptor 3 Homo sapiens 13.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246779 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246779&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823336 376222355 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491169 CCOC(=O)c1noc(n1)-c1c[nH]\c(=N/c2ccc(Oc3ccon3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H19ClN6O6/c1-2-35-24(34)21-29-22(38-31-21)19-13-27-25(32(23(19)33)14-15-3-5-16(26)6-4-15)28-17-7-9-18(10-8-17)37-20-11-12-36-30-20/h3-13H,2,14H2,1H3,(H,27,28) NBSGPICPDGVZIY-UHFFFAOYSA-N 246780 US9550763, Compound I-437 P2X purinoceptor 3 Homo sapiens 124 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246780 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246780&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823337 376222356 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491170 COC(=O)c1nnc(o1)-c1c[nH]\c(=N/c2ccc(Oc3ccon3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H17ClN6O6/c1-34-23(33)21-29-28-20(37-21)18-12-26-24(31(22(18)32)13-14-2-4-15(25)5-3-14)27-16-6-8-17(9-7-16)36-19-10-11-35-30-19/h2-12H,13H2,1H3,(H,26,27) GKYHQTYZVHODKG-UHFFFAOYSA-N 246781 US9550763, Compound I-438 P2X purinoceptor 3 Homo sapiens 109 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246781 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246781&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823338 376222357 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491171 Clc1ccc(Cn2c(=O)c(c[nH]\c2=N/c2ccc(Oc3ccon3)cc2)-c2nnco2)cc1 InChI=1S/C22H15ClN6O4/c23-15-3-1-14(2-4-15)12-29-21(30)18(20-27-25-13-31-20)11-24-22(29)26-16-5-7-17(8-6-16)33-19-9-10-32-28-19/h1-11,13H,12H2,(H,24,26) GHOACSSBDDOTIB-UHFFFAOYSA-N 246782 US9550763, Compound I-439 P2X purinoceptor 3 Homo sapiens 47.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246782 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246782&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823339 376222358 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491172 OC(=O)c1cccc(Oc2ccc(cc2)\N=c2/[nH]cc(Br)c(=O)n2Cc2ccc(Cl)cc2)n1 InChI=1S/C23H16BrClN4O4/c24-18-12-26-23(29(21(18)30)13-14-4-6-15(25)7-5-14)27-16-8-10-17(11-9-16)33-20-3-1-2-19(28-20)22(31)32/h1-12H,13H2,(H,26,27)(H,31,32) JTPOLCIPTYRTGV-UHFFFAOYSA-N 246783 US9550763, Compound I-440 P2X purinoceptor 3 Homo sapiens 15.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246783 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246783&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823340 376222359 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491173 NC(=O)c1noc(n1)-c1c[nH]\c(=N/c2ccc(Oc3ccon3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H16ClN7O5/c24-14-3-1-13(2-4-14)12-31-22(33)17(21-28-20(19(25)32)30-36-21)11-26-23(31)27-15-5-7-16(8-6-15)35-18-9-10-34-29-18/h1-11H,12H2,(H2,25,32)(H,26,27) YTAKPYNJJLVWPM-UHFFFAOYSA-N 246784 US9550763, Compound I-441 P2X purinoceptor 3 Homo sapiens 69.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246784 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246784&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823341 376222360 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491174 CNC(=O)c1noc(n1)-c1c[nH]\c(=N/c2ccc(Oc3ccon3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H18ClN7O5/c1-26-21(33)20-29-22(37-31-20)18-12-27-24(32(23(18)34)13-14-2-4-15(25)5-3-14)28-16-6-8-17(9-7-16)36-19-10-11-35-30-19/h2-12H,13H2,1H3,(H,26,33)(H,27,28) URUDGQREHQRJFP-UHFFFAOYSA-N 246785 US9550763, Compound I-442 P2X purinoceptor 3 Homo sapiens 80.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246785 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246785&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823342 376222361 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491175 C[C@@H](NC(=O)c1cn(Cc2ccc(Cl)cc2)c(Nc2ccc(Oc3cccc(F)n3)cc2)nc1=O)C(N)=O InChI=1S/C26H22ClFN6O4/c1-15(23(29)35)30-24(36)20-14-34(13-16-5-7-17(27)8-6-16)26(33-25(20)37)31-18-9-11-19(12-10-18)38-22-4-2-3-21(28)32-22/h2-12,14-15H,13H2,1H3,(H2,29,35)(H,30,36)(H,31,33,37)/t15-/m1/s1 DVEHBGVRSYWWAZ-OAHLLOKOSA-N 246786 US9550763, Compound I-443 P2X purinoceptor 3 Homo sapiens 36.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246786 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246786&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118683515 376222362 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491176 COC(=O)C(C)(C)Cn1c(=O)cc(Nc2ccc(Oc3ccc(F)cn3)c(C)n2)n(C[C@H]2CC[C@H](C)CC2)c1=O InChI=1S/C29H36FN5O5/c1-18-6-8-20(9-7-18)16-34-24(14-26(36)35(28(34)38)17-29(3,4)27(37)39-5)33-23-12-11-22(19(2)32-23)40-25-13-10-21(30)15-31-25/h10-15,18,20H,6-9,16-17H2,1-5H3,(H,32,33)/t18-,20- XCUAHEMXGJNALC-KESTWPANSA-N 246787 US9550763, Compound I-444 P2X purinoceptor 3 Homo sapiens 9.00 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246787 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246787&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823343 376222363 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491177 C[C@H]1CC[C@H](Cn2c(Nc3ccc(Oc4ccc(F)cn4)c(C)n3)cc(=O)n(CC(C)(C)C(O)=O)c2=O)CC1 InChI=1S/C28H34FN5O5/c1-17-5-7-19(8-6-17)15-33-23(13-25(35)34(27(33)38)16-28(3,4)26(36)37)32-22-11-10-21(18(2)31-22)39-24-12-9-20(29)14-30-24/h9-14,17,19H,5-8,15-16H2,1-4H3,(H,31,32)(H,36,37)/t17-,19- YCNQYFNVAYFHBN-UAPYVXQJSA-N 246788 US9550763, Compound I-445 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246788 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246788&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823344 376222364 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491178 COC(=O)[C@H](CO)NC(=O)c1c[nH]\c(=N/c2ccc(Oc3ccon3)cc2)n(Cc2ccc(Cl)cc2)c1=O 246789 US9550763, Compound I-446 P2X purinoceptor 3 Homo sapiens 47.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246789 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246789&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823345 376222365 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491179 Clc1ccc(Cn2c(=O)c(c[nH]\c2=N/c2ccc(Oc3ccon3)cc2)-c2ncno2)cc1 InChI=1S/C22H15ClN6O4/c23-15-3-1-14(2-4-15)12-29-21(30)18(20-25-13-26-33-20)11-24-22(29)27-16-5-7-17(8-6-16)32-19-9-10-31-28-19/h1-11,13H,12H2,(H,24,27) OYBGTMMHBYEXHG-UHFFFAOYSA-N 246790 US9550763, Compound I-449 P2X purinoceptor 3 Homo sapiens 179 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246790 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246790&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823346 376222366 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491180 Clc1ccc(Cn2c(=O)c(c[nH]\c2=N/c2ccc(Oc3ccon3)cc2)C(=O)NCC=C)cc1 InChI=1S/C24H20ClN5O4/c1-2-12-26-22(31)20-14-27-24(30(23(20)32)15-16-3-5-17(25)6-4-16)28-18-7-9-19(10-8-18)34-21-11-13-33-29-21/h2-11,13-14H,1,12,15H2,(H,26,31)(H,27,28) KOQLLRUKZUHTPT-UHFFFAOYSA-N 246791 US9550763, Compound I-450 P2X purinoceptor 3 Homo sapiens 21.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246791 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246791&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823347 376222367 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491181 Clc1ccc(Cn2c(=O)c(c[nH]\c2=N/c2ccc(Oc3ccon3)cc2)C(=O)NCc2ccccc2)cc1 InChI=1S/C28H22ClN5O4/c29-21-8-6-20(7-9-21)18-34-27(36)24(26(35)30-16-19-4-2-1-3-5-19)17-31-28(34)32-22-10-12-23(13-11-22)38-25-14-15-37-33-25/h1-15,17H,16,18H2,(H,30,35)(H,31,32) KXZASUQBWLCKFY-UHFFFAOYSA-N 246792 US9550763, Compound I-451 P2X purinoceptor 3 Homo sapiens 104 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246792 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246792&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823348 376222368 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491182 FC(F)(F)CNC(=O)c1c[nH]\c(=N/c2ccc(Oc3ccon3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H17ClF3N5O4/c24-15-3-1-14(2-4-15)12-32-21(34)18(20(33)29-13-23(25,26)27)11-28-22(32)30-16-5-7-17(8-6-16)36-19-9-10-35-31-19/h1-11H,12-13H2,(H,28,30)(H,29,33) SWVARRGJARKZDV-UHFFFAOYSA-N 246793 US9550763, Compound I-452 P2X purinoceptor 3 Homo sapiens 98.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246793 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246793&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823349 376222369 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491183 OC(=O)c1coc(n1)-c1c[nH]\c(=N/c2ccc(Oc3ccon3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H16ClN5O6/c25-15-3-1-14(2-4-15)12-30-22(31)18(21-28-19(13-34-21)23(32)33)11-26-24(30)27-16-5-7-17(8-6-16)36-20-9-10-35-29-20/h1-11,13H,12H2,(H,26,27)(H,32,33) PWKUJMLXFDYNEF-UHFFFAOYSA-N 246794 US9550763, Compound I-454 P2X purinoceptor 3 Homo sapiens 160 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246794 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246794&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823350 376222370 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491184 CCn1c(=O)[nH]c(Nc2ccc(Oc3cccc(n3)C#N)cc2)c(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H20ClN5O3/c1-2-31-24(32)21(14-16-6-8-17(26)9-7-16)23(30-25(31)33)29-18-10-12-20(13-11-18)34-22-5-3-4-19(15-27)28-22/h3-13,29H,2,14H2,1H3,(H,30,33) CVPMGOSTTQEPDL-UHFFFAOYSA-N 246795 US9550763, Compound I-456 P2X purinoceptor 3 Homo sapiens 9.00 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246795 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246795&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823351 376222371 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491185 CCn1c(=O)[nH]c(Nc2ccc(Oc3cccc(n3)C(O)=O)cc2)c(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H21ClN4O5/c1-2-30-23(31)19(14-15-6-8-16(26)9-7-15)22(29-25(30)34)27-17-10-12-18(13-11-17)35-21-5-3-4-20(28-21)24(32)33/h3-13,27H,2,14H2,1H3,(H,29,34)(H,32,33) PMFRVLAQVMSOBT-UHFFFAOYSA-N 246796 US9550763, Compound I-457 P2X purinoceptor 3 Homo sapiens 9.00 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246796 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246796&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823352 376222372 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491186 CCn1c(=O)[nH]c(Nc2ccc(Oc3cccc(n3)C(N)=O)cc2)c(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H22ClN5O4/c1-2-31-24(33)19(14-15-6-8-16(26)9-7-15)23(30-25(31)34)28-17-10-12-18(13-11-17)35-21-5-3-4-20(29-21)22(27)32/h3-13,28H,2,14H2,1H3,(H2,27,32)(H,30,34) VYGMCGAMUHKONS-UHFFFAOYSA-N 246797 US9550763, Compound I-458 P2X purinoceptor 3 Homo sapiens 15.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246797 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246797&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823353 376222373 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491187 CCOC(=O)c1cn(Cc2ccc(Cl)cc2)c(Nc2ccc(Oc3ccc(F)cn3)cc2)cc1=O InChI=1S/C26H21ClFN3O4/c1-2-34-26(33)22-16-31(15-17-3-5-18(27)6-4-17)24(13-23(22)32)30-20-8-10-21(11-9-20)35-25-12-7-19(28)14-29-25/h3-14,16,30H,2,15H2,1H3 GGENPVZXCBQIBD-UHFFFAOYSA-N 246798 US9550763, Compound I-463 P2X purinoceptor 3 Homo sapiens 26.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246798 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246798&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 89745337 376222374 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491188 CC(C)n1ccc(Nc2ccc(Oc3cccc(n3)C(O)=O)cc2)c(Cc2ccc(Cl)cc2)c1=O InChI=1S/C27H24ClN3O4/c1-17(2)31-15-14-23(22(26(31)32)16-18-6-8-19(28)9-7-18)29-20-10-12-21(13-11-20)35-25-5-3-4-24(30-25)27(33)34/h3-15,17,29H,16H2,1-2H3,(H,33,34) FGZPWXOPQLRKMU-UHFFFAOYSA-N 246799 US9550763, Compound I-466 P2X purinoceptor 3 Homo sapiens 597 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246799 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246799&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118683526 376222375 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491189 COC(=O)c1cccc(Oc2ccc(cc2)\N=c2/[nH]cc(c(=O)n2Cc2ccc(Cl)cc2)C(F)(F)F)n1 InChI=1S/C25H18ClF3N4O4/c1-36-23(35)20-3-2-4-21(32-20)37-18-11-9-17(10-12-18)31-24-30-13-19(25(27,28)29)22(34)33(24)14-15-5-7-16(26)8-6-15/h2-13H,14H2,1H3,(H,30,31) KPJWRINKPBJKEA-UHFFFAOYSA-N 246800 US9550763, Compound I-471 P2X purinoceptor 3 Homo sapiens 683 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246800 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246800&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823354 376222376 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491190 OC(=O)c1cccc(Oc2ccc(cc2)\N=c2/[nH]cc(c(=O)n2Cc2ccc(Cl)cc2)C(F)(F)F)n1 InChI=1S/C24H16ClF3N4O4/c25-15-6-4-14(5-7-15)13-32-21(33)18(24(26,27)28)12-29-23(32)30-16-8-10-17(11-9-16)36-20-3-1-2-19(31-20)22(34)35/h1-12H,13H2,(H,29,30)(H,34,35) UEBTVGKZBQFYKI-UHFFFAOYSA-N 246801 US9550763, Compound I-472 P2X purinoceptor 3 Homo sapiens 15.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246801 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246801&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823355 376222377 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491191 CCCn1c(=O)cc(Nc2ccc(Oc3cccc(c3)C#N)c(C)n2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C28H27N5O3/c1-4-14-32-27(34)16-26(33(28(32)35)18-21-10-8-19(2)9-11-21)31-25-13-12-24(20(3)30-25)36-23-7-5-6-22(15-23)17-29/h5-13,15-16H,4,14,18H2,1-3H3,(H,30,31) KVGAIBKXLOYSGP-UHFFFAOYSA-N 246802 US9550763, Compound I-473 P2X purinoceptor 3 Homo sapiens 29.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246802 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246802&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823356 376222378 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491192 CCCn1c(=O)cc(Nc2ccc(Oc3cccc(c3)C(O)=O)c(C)n2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C28H28N4O5/c1-4-14-31-26(33)16-25(32(28(31)36)17-20-10-8-18(2)9-11-20)30-24-13-12-23(19(3)29-24)37-22-7-5-6-21(15-22)27(34)35/h5-13,15-16H,4,14,17H2,1-3H3,(H,29,30)(H,34,35) OWPLOUSZYUQLDC-UHFFFAOYSA-N 246803 US9550763, Compound I-474 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246803 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246803&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823357 376222379 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491193 COC(=O)c1cccc(Oc2ccc(cc2)\N=c2/[nH]cc(C3CCOCC3)c(=O)n2Cc2ccc(Cl)cc2)n1 InChI=1S/C29H27ClN4O5/c1-37-28(36)25-3-2-4-26(33-25)39-23-11-9-22(10-12-23)32-29-31-17-24(20-13-15-38-16-14-20)27(35)34(29)18-19-5-7-21(30)8-6-19/h2-12,17,20H,13-16,18H2,1H3,(H,31,32) GLDZODMQAMDADB-UHFFFAOYSA-N 246804 US9550763, Compound I-476 P2X purinoceptor 3 Homo sapiens 66.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246804 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246804&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823358 376222380 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491194 CC(C)(C)c1c[nH]\c(=N/c2ccc(Oc3cccc(n3)C(O)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C27H25ClN4O4/c1-27(2,3)21-15-29-26(32(24(21)33)16-17-7-9-18(28)10-8-17)30-19-11-13-20(14-12-19)36-23-6-4-5-22(31-23)25(34)35/h4-15H,16H2,1-3H3,(H,29,30)(H,34,35) UYTVKMAQVYHWPU-UHFFFAOYSA-N 246805 US9550763, Compound I-477 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246805 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246805&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823359 376222381 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491195 OC(=O)c1cccc(Oc2ccc(cc2)\N=c2/[nH]cc(C3CCOCC3)c(=O)n2Cc2ccc(Cl)cc2)n1 InChI=1S/C28H25ClN4O5/c29-20-6-4-18(5-7-20)17-33-26(34)23(19-12-14-37-15-13-19)16-30-28(33)31-21-8-10-22(11-9-21)38-25-3-1-2-24(32-25)27(35)36/h1-11,16,19H,12-15,17H2,(H,30,31)(H,35,36) XNRGEUOBKZKRTP-UHFFFAOYSA-N 246806 US9550763, Compound I-478 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246806 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246806&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823360 376222382 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491196 OC(=O)c1cccc(Oc2ccc(cc2)\N=c2/[nH]cc(-c3ccccn3)c(=O)n2Cc2ccc(Cl)cc2)n1 InChI=1S/C28H20ClN5O4/c29-19-9-7-18(8-10-19)17-34-26(35)22(23-4-1-2-15-30-23)16-31-28(34)32-20-11-13-21(14-12-20)38-25-6-3-5-24(33-25)27(36)37/h1-16H,17H2,(H,31,32)(H,36,37) NHQPNXRBAXQVEL-UHFFFAOYSA-N 246807 US9550763, Compound I-480 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246807 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246807&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823361 376222383 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491197 CC(C)(C)c1c[nH]\c(=N/c2ccc(Oc3cccc(n3)C(N)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C27H26ClN5O3/c1-27(2,3)21-15-30-26(33(25(21)35)16-17-7-9-18(28)10-8-17)31-19-11-13-20(14-12-19)36-23-6-4-5-22(32-23)24(29)34/h4-15H,16H2,1-3H3,(H2,29,34)(H,30,31) YWFLDMKIEVBGDO-UHFFFAOYSA-N 246808 US9550763, Compound I-482 P2X purinoceptor 3 Homo sapiens 251 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246808 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246808&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823362 376222384 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491198 NC(=O)c1cccc(Oc2ccc(cc2)\N=c2/[nH]cc(C3CCOCC3)c(=O)n2Cc2ccc(Cl)cc2)n1 InChI=1S/C28H26ClN5O4/c29-20-6-4-18(5-7-20)17-34-27(36)23(19-12-14-37-15-13-19)16-31-28(34)32-21-8-10-22(11-9-21)38-25-3-1-2-24(33-25)26(30)35/h1-11,16,19H,12-15,17H2,(H2,30,35)(H,31,32) OSJCLZAQVRTOLW-UHFFFAOYSA-N 246809 US9550763, Compound I-483 P2X purinoceptor 3 Homo sapiens 17.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246809 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246809&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823363 376222385 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491099 C[C@@H](Cn1c(=O)cc(Nc2ccc(Oc3ccc(F)cn3)c(C)n2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O InChI=1S/C26H23ClFN5O5/c1-15(25(35)36)13-33-24(34)11-22(32(26(33)37)14-17-3-5-18(27)6-4-17)31-21-9-8-20(16(2)30-21)38-23-10-7-19(28)12-29-23/h3-12,15H,13-14H2,1-2H3,(H,30,31)(H,35,36)/t15-/m0/s1 CMBLPGVFNSIISG-HNNXBMFYSA-N 246710 US9550763, Compound I-363 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246710 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246710&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823311 376222286 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491100 COC(=O)C(C)(C)Cn1c(=O)cc(Nc2ccc(Oc3ccc(F)cn3)c(C)n2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C28H27ClFN5O5/c1-17-21(40-24-12-9-20(30)14-31-24)10-11-22(32-17)33-23-13-25(36)35(16-28(2,3)26(37)39-4)27(38)34(23)15-18-5-7-19(29)8-6-18/h5-14H,15-16H2,1-4H3,(H,32,33) VIFHXMDDCISCKS-UHFFFAOYSA-N 246711 US9550763, Compound I-364 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246711 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246711&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823312 376222287 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491101 Cc1nc(Nc2cc(=O)n(CC(C)(C)C(O)=O)c(=O)n2Cc2ccc(Cl)cc2)ccc1Oc1ccc(F)cn1 InChI=1S/C27H25ClFN5O5/c1-16-20(39-23-11-8-19(29)13-30-23)9-10-21(31-16)32-22-12-24(35)34(15-27(2,3)25(36)37)26(38)33(22)14-17-4-6-18(28)7-5-17/h4-13H,14-15H2,1-3H3,(H,31,32)(H,36,37) BUAIDDDVFUDWEI-UHFFFAOYSA-N 246712 US9550763, Compound I-365 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246712 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246712&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823313 376222288 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491102 COC(=O)c1ccc(Oc2ccc(cc2)\N=c2/[nH]cc(C(C)C)c(=O)n2Cc2ccc(Cl)cc2)nc1 InChI=1S/C27H25ClN4O4/c1-17(2)23-15-30-27(32(25(23)33)16-18-4-7-20(28)8-5-18)31-21-9-11-22(12-10-21)36-24-13-6-19(14-29-24)26(34)35-3/h4-15,17H,16H2,1-3H3,(H,30,31) IVDAJRXMFGGAMS-UHFFFAOYSA-N 246713 US9550763, Compound I-366 P2X purinoceptor 3 Homo sapiens 91.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246713 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246713&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823314 376222289 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491103 COC(=O)c1cncc(Oc2ccc(cc2)\N=c2/[nH]cc(C(C)C)c(=O)n2Cc2ccc(Cl)cc2)c1 InChI=1S/C27H25ClN4O4/c1-17(2)24-15-30-27(32(25(24)33)16-18-4-6-20(28)7-5-18)31-21-8-10-22(11-9-21)36-23-12-19(13-29-14-23)26(34)35-3/h4-15,17H,16H2,1-3H3,(H,30,31) HONNOLYEPYJKRW-UHFFFAOYSA-N 246714 US9550763, Compound I-367 P2X purinoceptor 3 Homo sapiens 471 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246714 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246714&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823315 376222290 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491104 Fc1cccc(Oc2ccc(Nc3nc(=O)c(cn3Cc3ccc(Cl)cc3)C(=O)NCc3ccco3)cc2)n1 InChI=1S/C28H21ClFN5O4/c29-19-8-6-18(7-9-19)16-35-17-23(26(36)31-15-22-3-2-14-38-22)27(37)34-28(35)32-20-10-12-21(13-11-20)39-25-5-1-4-24(30)33-25/h1-14,17H,15-16H2,(H,31,36)(H,32,34,37) XKPBZLUTHNLRQX-UHFFFAOYSA-N 246715 US9550763, Compound I-369 P2X purinoceptor 3 Homo sapiens 120 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246715 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246715&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118683465 376222291 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491105 CC(=O)NCCNC(=O)c1cn(Cc2ccc(Cl)cc2)c(Nc2ccc(Oc3cccc(F)n3)cc2)nc1=O InChI=1S/C27H24ClFN6O4/c1-17(36)30-13-14-31-25(37)22-16-35(15-18-5-7-19(28)8-6-18)27(34-26(22)38)32-20-9-11-21(12-10-20)39-24-4-2-3-23(29)33-24/h2-12,16H,13-15H2,1H3,(H,30,36)(H,31,37)(H,32,34,38) SCGYBEQAAMCTTR-UHFFFAOYSA-N 246716 US9550763, Compound I-370 P2X purinoceptor 3 Homo sapiens 384 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246716 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246716&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118683464 376222292 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491106 Cc1cc(NC(=O)c2cn(Cc3ccc(Cl)cc3)c(Nc3ccc(Oc4cccc(F)n4)cc3)nc2=O)no1 InChI=1S/C27H20ClFN6O4/c1-16-13-23(34-39-16)32-25(36)21-15-35(14-17-5-7-18(28)8-6-17)27(33-26(21)37)30-19-9-11-20(12-10-19)38-24-4-2-3-22(29)31-24/h2-13,15H,14H2,1H3,(H,30,33,37)(H,32,34,36) JAYMCRATYYZHAC-UHFFFAOYSA-N 246717 US9550763, Compound I-371 P2X purinoceptor 3 Homo sapiens 80.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246717 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246717&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118683467 376222293 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491107 Fc1cccc(Oc2ccc(Nc3nc(=O)c(cn3Cc3ccc(Cl)cc3)C(=O)Nc3ccon3)cc2)n1 InChI=1S/C26H18ClFN6O4/c27-17-6-4-16(5-7-17)14-34-15-20(24(35)31-22-12-13-37-33-22)25(36)32-26(34)29-18-8-10-19(11-9-18)38-23-3-1-2-21(28)30-23/h1-13,15H,14H2,(H,29,32,36)(H,31,33,35) AVZCCIWFOPNLMW-UHFFFAOYSA-N 246718 US9550763, Compound I-372 P2X purinoceptor 3 Homo sapiens 51.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246718 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246718&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118683471 376222294 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491108 COCCCNC(=O)c1cn(Cc2ccc(Cl)cc2)c(Nc2ccc(Oc3cccc(F)n3)cc2)nc1=O InChI=1S/C27H25ClFN5O4/c1-37-15-3-14-30-25(35)22-17-34(16-18-6-8-19(28)9-7-18)27(33-26(22)36)31-20-10-12-21(13-11-20)38-24-5-2-4-23(29)32-24/h2,4-13,17H,3,14-16H2,1H3,(H,30,35)(H,31,33,36) GLTPMHOGIWNHHH-UHFFFAOYSA-N 246719 US9550763, Compound I-373 P2X purinoceptor 3 Homo sapiens 136 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246719 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246719&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118683466 376222295 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491109 CC(C)CNC(=O)c1cn(Cc2ccc(Cl)cc2)c(Nc2ccc(Oc3cccc(F)n3)cc2)nc1=O InChI=1S/C27H25ClFN5O3/c1-17(2)14-30-25(35)22-16-34(15-18-6-8-19(28)9-7-18)27(33-26(22)36)31-20-10-12-21(13-11-20)37-24-5-3-4-23(29)32-24/h3-13,16-17H,14-15H2,1-2H3,(H,30,35)(H,31,33,36) OXZVVDNLUMNMAM-UHFFFAOYSA-N 246720 US9550763, Compound I-374 P2X purinoceptor 3 Homo sapiens 46.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246720 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246720&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118683468 376222296 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491110 NC(=O)[C@H](CO)NC(=O)c1cn(Cc2ccc(Cl)cc2)c(Nc2ccc(Oc3cccc(F)n3)cc2)nc1=O InChI=1S/C26H22ClFN6O5/c27-16-6-4-15(5-7-16)12-34-13-19(24(37)31-20(14-35)23(29)36)25(38)33-26(34)30-17-8-10-18(11-9-17)39-22-3-1-2-21(28)32-22/h1-11,13,20,35H,12,14H2,(H2,29,36)(H,31,37)(H,30,33,38)/t20-/m0/s1 RPWIPDNQNZPPGX-FQEVSTJZSA-N 246721 US9550763, Compound I-375 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246721 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246721&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118683474 376222297 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491111 Fc1cccc(Oc2ccc(Nc3nc(=O)c(cn3Cc3ccc(Cl)cc3)C(=O)NC3CCCC3)cc2)n1 InChI=1S/C28H25ClFN5O3/c29-19-10-8-18(9-11-19)16-35-17-23(26(36)31-20-4-1-2-5-20)27(37)34-28(35)32-21-12-14-22(15-13-21)38-25-7-3-6-24(30)33-25/h3,6-15,17,20H,1-2,4-5,16H2,(H,31,36)(H,32,34,37) PYEUKUKVROVPCB-UHFFFAOYSA-N 246722 US9550763, Compound I-376 P2X purinoceptor 3 Homo sapiens 40.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246722 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246722&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118683472 376222298 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491112 Cc1noc(C)c1NC(=O)c1cn(Cc2ccc(Cl)cc2)c(Nc2ccc(Oc3cccc(F)n3)cc2)nc1=O InChI=1S/C28H22ClFN6O4/c1-16-25(17(2)40-35-16)33-26(37)22-15-36(14-18-6-8-19(29)9-7-18)28(34-27(22)38)31-20-10-12-21(13-11-20)39-24-5-3-4-23(30)32-24/h3-13,15H,14H2,1-2H3,(H,33,37)(H,31,34,38) QZRZBMWACVTYFC-UHFFFAOYSA-N 246723 US9550763, Compound I-377 P2X purinoceptor 3 Homo sapiens 37.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246723 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246723&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118683476 376222299 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491113 Cn1ccc(NC(=O)c2cn(Cc3ccc(Cl)cc3)c(Nc3ccc(Oc4cccc(F)n4)cc3)nc2=O)n1 InChI=1S/C27H21ClFN7O3/c1-35-14-13-23(34-35)32-25(37)21-16-36(15-17-5-7-18(28)8-6-17)27(33-26(21)38)30-19-9-11-20(12-10-19)39-24-4-2-3-22(29)31-24/h2-14,16H,15H2,1H3,(H,30,33,38)(H,32,34,37) XFBPWZHYVGSVNA-UHFFFAOYSA-N 246724 US9550763, Compound I-378 P2X purinoceptor 3 Homo sapiens 20.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246724 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246724&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118683470 376222300 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491114 Fc1cccc(Oc2ccc(Nc3nc(=O)c(cn3Cc3ccc(Cl)cc3)C(=O)NCC3COCCO3)cc2)n1 InChI=1S/C28H25ClFN5O5/c29-19-6-4-18(5-7-19)15-35-16-23(26(36)31-14-22-17-38-12-13-39-22)27(37)34-28(35)32-20-8-10-21(11-9-20)40-25-3-1-2-24(30)33-25/h1-11,16,22H,12-15,17H2,(H,31,36)(H,32,34,37) ZBKYCPUDWLFJDA-UHFFFAOYSA-N 246725 US9550763, Compound I-379 P2X purinoceptor 3 Homo sapiens 96.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246725 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246725&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118683469 376222301 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491115 CC(C)[C@H](NC(=O)c1cn(Cc2ccc(Cl)cc2)c(Nc2ccc(Oc3cccc(F)n3)cc2)nc1=O)C(N)=O InChI=1S/C28H26ClFN6O4/c1-16(2)24(25(31)37)34-26(38)21-15-36(14-17-6-8-18(29)9-7-17)28(35-27(21)39)32-19-10-12-20(13-11-19)40-23-5-3-4-22(30)33-23/h3-13,15-16,24H,14H2,1-2H3,(H2,31,37)(H,34,38)(H,32,35,39)/t24-/m0/s1 VKZHEQKPOGZJLL-DEOSSOPVSA-N 246726 US9550763, Compound I-380 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246726 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246726&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 89745538 376222302 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491116 C[C@H](NC(=O)c1cn(Cc2ccc(Cl)cc2)c(Nc2ccc(Oc3cccc(F)n3)cc2)nc1=O)C(N)=O InChI=1S/C26H22ClFN6O4/c1-15(23(29)35)30-24(36)20-14-34(13-16-5-7-17(27)8-6-16)26(33-25(20)37)31-18-9-11-19(12-10-18)38-22-4-2-3-21(28)32-22/h2-12,14-15H,13H2,1H3,(H2,29,35)(H,30,36)(H,31,33,37)/t15-/m0/s1 DVEHBGVRSYWWAZ-HNNXBMFYSA-N 246727 US9550763, Compound I-381 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246727 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246727&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118683477 376222303 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491117 Fc1cccc(Oc2ccc(Nc3nc(=O)c(cn3Cc3ccc(Cl)cc3)C(=O)NCC(=O)N3CCCCC3)cc2)n1 InChI=1S/C30H28ClFN6O4/c31-21-9-7-20(8-10-21)18-38-19-24(28(40)33-17-27(39)37-15-2-1-3-16-37)29(41)36-30(38)34-22-11-13-23(14-12-22)42-26-6-4-5-25(32)35-26/h4-14,19H,1-3,15-18H2,(H,33,40)(H,34,36,41) VVNKKFIBEPGCPL-UHFFFAOYSA-N 246728 US9550763, Compound I-382 P2X purinoceptor 3 Homo sapiens 9.00 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246728 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246728&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118683473 376222304 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491118 Fc1cccc(Oc2ccc(Nc3nc(=O)c(cn3Cc3ccc(Cl)cc3)C(=O)NC3CCCOC3)cc2)n1 InChI=1S/C28H25ClFN5O4/c29-19-8-6-18(7-9-19)15-35-16-23(26(36)31-21-3-2-14-38-17-21)27(37)34-28(35)32-20-10-12-22(13-11-20)39-25-5-1-4-24(30)33-25/h1,4-13,16,21H,2-3,14-15,17H2,(H,31,36)(H,32,34,37) ABXAOTAAINPJIN-UHFFFAOYSA-N 246729 US9550763, Compound I-383 P2X purinoceptor 3 Homo sapiens 13.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246729 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246729&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118683475 376222305 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491119 Fc1cccc(Oc2ccc(Nc3nc(=O)c(cn3Cc3ccc(Cl)cc3)C(=O)NCc3ncco3)cc2)n1 InChI=1S/C27H20ClFN6O4/c28-18-6-4-17(5-7-18)15-35-16-21(25(36)31-14-24-30-12-13-38-24)26(37)34-27(35)32-19-8-10-20(11-9-19)39-23-3-1-2-22(29)33-23/h1-13,16H,14-15H2,(H,31,36)(H,32,34,37) HENYCZFNXLWGPB-UHFFFAOYSA-N 246730 US9550763, Compound I-384 P2X purinoceptor 3 Homo sapiens 60.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246730 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246730&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 89745540 376222306 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491120 CC1(CCOCC1)NC(=O)c1cn(Cc2ccc(Cl)cc2)c(Nc2ccc(Oc3cccc(F)n3)cc2)nc1=O InChI=1S/C29H27ClFN5O4/c1-29(13-15-39-16-14-29)35-27(38)23-18-36(17-19-5-7-20(30)8-6-19)28(34-26(23)37)32-21-9-11-22(12-10-21)40-25-4-2-3-24(31)33-25/h2-12,18H,13-17H2,1H3,(H,35,38)(H,32,34,37) JGYLKDLXIABJPC-UHFFFAOYSA-N 246731 US9550763, Compound I-385 P2X purinoceptor 3 Homo sapiens 16.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246731 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246731&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118683478 376222307 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491121 Fc1cccc(Oc2ccc(Nc3nc(=O)c(cn3Cc3ccc(Cl)cc3)C(=O)NC[C@@H]3CCCO3)cc2)n1 InChI=1S/C28H25ClFN5O4/c29-19-8-6-18(7-9-19)16-35-17-23(26(36)31-15-22-3-2-14-38-22)27(37)34-28(35)32-20-10-12-21(13-11-20)39-25-5-1-4-24(30)33-25/h1,4-13,17,22H,2-3,14-16H2,(H,31,36)(H,32,34,37)/t22-/m0/s1 PQNIQCPBZQDYAY-QFIPXVFZSA-N 246732 US9550763, Compound I-386 P2X purinoceptor 3 Homo sapiens 15.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246732 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246732&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118683479 376222308 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491122 Fc1cccc(Oc2ccc(Nc3nc(=O)c(cn3Cc3ccc(Cl)cc3)C(=O)NC[C@H]3CCCO3)cc2)n1 InChI=1S/C28H25ClFN5O4/c29-19-8-6-18(7-9-19)16-35-17-23(26(36)31-15-22-3-2-14-38-22)27(37)34-28(35)32-20-10-12-21(13-11-20)39-25-5-1-4-24(30)33-25/h1,4-13,17,22H,2-3,14-16H2,(H,31,36)(H,32,34,37)/t22-/m1/s1 PQNIQCPBZQDYAY-JOCHJYFZSA-N 246733 US9550763, Compound I-387 P2X purinoceptor 3 Homo sapiens 14.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246733 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246733&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 89745492 376222309 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491123 Fc1cccc(Oc2ccc(Nc3nc(=O)c(cn3Cc3ccc(Cl)cc3)C(=O)NCC3CCCCO3)cc2)n1 InChI=1S/C29H27ClFN5O4/c30-20-9-7-19(8-10-20)17-36-18-24(27(37)32-16-23-4-1-2-15-39-23)28(38)35-29(36)33-21-11-13-22(14-12-21)40-26-6-3-5-25(31)34-26/h3,5-14,18,23H,1-2,4,15-17H2,(H,32,37)(H,33,35,38) QKJYOTIKUQOOMI-UHFFFAOYSA-N 246734 US9550763, Compound I-388 P2X purinoceptor 3 Homo sapiens 29.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246734 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246734&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 89745493 376222310 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491124 Fc1cccc(Oc2ccc(Nc3nc(=O)c(cn3Cc3ccc(Cl)cc3)C(=O)NC3CCNC3=O)cc2)n1 InChI=1S/C27H22ClFN6O4/c28-17-6-4-16(5-7-17)14-35-15-20(24(36)32-21-12-13-30-26(21)38)25(37)34-27(35)31-18-8-10-19(11-9-18)39-23-3-1-2-22(29)33-23/h1-11,15,21H,12-14H2,(H,30,38)(H,32,36)(H,31,34,37) CJIZFKJJIVQBEZ-UHFFFAOYSA-N 246735 US9550763, Compound I-389 P2X purinoceptor 3 Homo sapiens 10.00 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246735 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246735&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118683480 376222311 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491125 OCC1(CCOCC1)NC(=O)c1cn(Cc2ccc(Cl)cc2)c(Nc2ccc(Oc3cccc(F)n3)cc2)nc1=O InChI=1S/C29H27ClFN5O5/c30-20-6-4-19(5-7-20)16-36-17-23(27(39)35-29(18-37)12-14-40-15-13-29)26(38)34-28(36)32-21-8-10-22(11-9-21)41-25-3-1-2-24(31)33-25/h1-11,17,37H,12-16,18H2,(H,35,39)(H,32,34,38) URBFNJLDNGCMCZ-UHFFFAOYSA-N 246736 US9550763, Compound I-390 P2X purinoceptor 3 Homo sapiens 59.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246736 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246736&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118683482 376222312 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491126 Cn1nccc1NC(=O)c1cn(Cc2ccc(Cl)cc2)c(Nc2ccc(Oc3cccc(F)n3)cc2)nc1=O InChI=1S/C27H21ClFN7O3/c1-35-23(13-14-30-35)33-25(37)21-16-36(15-17-5-7-18(28)8-6-17)27(34-26(21)38)31-19-9-11-20(12-10-19)39-24-4-2-3-22(29)32-24/h2-14,16H,15H2,1H3,(H,33,37)(H,31,34,38) ZZPOMFNRRPKTDT-UHFFFAOYSA-N 246737 US9550763, Compound I-391 P2X purinoceptor 3 Homo sapiens 30.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246737 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246737&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118683481 376222313 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491127 Cc1nc(CNC(=O)c2cn(Cc3ccc(Cl)cc3)c(Nc3ccc(Oc4cccc(F)n4)cc3)nc2=O)no1 InChI=1S/C27H21ClFN7O4/c1-16-31-23(35-40-16)13-30-25(37)21-15-36(14-17-5-7-18(28)8-6-17)27(34-26(21)38)32-19-9-11-20(12-10-19)39-24-4-2-3-22(29)33-24/h2-12,15H,13-14H2,1H3,(H,30,37)(H,32,34,38) SJCJTPFDBKPUFK-UHFFFAOYSA-N 246738 US9550763, Compound I-392 P2X purinoceptor 3 Homo sapiens 128 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246738 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246738&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118683483 376222314 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491128 Fc1cccc(Oc2ccc(Nc3nc(=O)c(cn3Cc3ccc(Cl)cc3)C(=O)NCC3CCCC3)cc2)n1 InChI=1S/C29H27ClFN5O3/c30-21-10-8-20(9-11-21)17-36-18-24(27(37)32-16-19-4-1-2-5-19)28(38)35-29(36)33-22-12-14-23(15-13-22)39-26-7-3-6-25(31)34-26/h3,6-15,18-19H,1-2,4-5,16-17H2,(H,32,37)(H,33,35,38) VUOGPAQWDWNUCL-UHFFFAOYSA-N 246739 US9550763, Compound I-393 P2X purinoceptor 3 Homo sapiens 110 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246739 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246739&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118683484 376222315 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491129 O[C@H]1COC[C@@H]1NC(=O)c1cn(Cc2ccc(Cl)cc2)c(Nc2ccc(Oc3cccc(F)n3)cc2)nc1=O InChI=1S/C27H23ClFN5O5/c28-17-6-4-16(5-7-17)12-34-13-20(25(36)31-21-14-38-15-22(21)35)26(37)33-27(34)30-18-8-10-19(11-9-18)39-24-3-1-2-23(29)32-24/h1-11,13,21-22,35H,12,14-15H2,(H,31,36)(H,30,33,37)/t21-,22-/m0/s1 ZRYOLXWTBLCYTN-VXKWHMMOSA-N 246740 US9550763, Compound I-394 P2X purinoceptor 3 Homo sapiens 11.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246740 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246740&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118683485 376222316 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491130 Fc1cccc(Oc2ccc(Nc3nc(=O)c(cn3Cc3ccc(Cl)cc3)C(=O)Nc3cn[nH]c3)cc2)n1 InChI=1S/C26H19ClFN7O3/c27-17-6-4-16(5-7-17)14-35-15-21(24(36)31-19-12-29-30-13-19)25(37)34-26(35)32-18-8-10-20(11-9-18)38-23-3-1-2-22(28)33-23/h1-13,15H,14H2,(H,29,30)(H,31,36)(H,32,34,37) DSDNNRWQFYISDC-UHFFFAOYSA-N 246741 US9550763, Compound I-395 P2X purinoceptor 3 Homo sapiens 22.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246741 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246741&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118683487 376222317 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491131 Fc1cccc(Oc2ccc(Nc3nc(=O)c(cn3Cc3ccc(Cl)cc3)C(=O)NCC3CCOC3)cc2)n1 InChI=1S/C28H25ClFN5O4/c29-20-6-4-18(5-7-20)15-35-16-23(26(36)31-14-19-12-13-38-17-19)27(37)34-28(35)32-21-8-10-22(11-9-21)39-25-3-1-2-24(30)33-25/h1-11,16,19H,12-15,17H2,(H,31,36)(H,32,34,37) OQISKPMCQRARHM-UHFFFAOYSA-N 246742 US9550763, Compound I-396 P2X purinoceptor 3 Homo sapiens 25.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246742 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246742&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118683486 376222318 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491132 Fc1cccc(Oc2ccc(Nc3nc(=O)c(cn3Cc3ccc(Cl)cc3)C(=O)Nc3cnoc3)cc2)n1 InChI=1S/C26H18ClFN6O4/c27-17-6-4-16(5-7-17)13-34-14-21(24(35)30-19-12-29-37-15-19)25(36)33-26(34)31-18-8-10-20(11-9-18)38-23-3-1-2-22(28)32-23/h1-12,14-15H,13H2,(H,30,35)(H,31,33,36) TYXZSDAMOJTBSY-UHFFFAOYSA-N 246743 US9550763, Compound I-397 P2X purinoceptor 3 Homo sapiens 56.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246743 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246743&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118683488 376222319 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491133 Fc1cccc(Oc2ccc(Nc3nc(=O)c(cn3Cc3ccc(Cl)cc3)C(=O)N[C@@H]3CCOC3)cc2)n1 InChI=1S/C27H23ClFN5O4/c28-18-6-4-17(5-7-18)14-34-15-22(25(35)30-20-12-13-37-16-20)26(36)33-27(34)31-19-8-10-21(11-9-19)38-24-3-1-2-23(29)32-24/h1-11,15,20H,12-14,16H2,(H,30,35)(H,31,33,36)/t20-/m1/s1 DLQLJZFYTOWENS-HXUWFJFHSA-N 246744 US9550763, Compound I-398 P2X purinoceptor 3 Homo sapiens 22.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246744 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246744&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118683489 376222320 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491134 OCc1nnc(o1)-c1c[nH]\c(=N/c2ccc(Oc3ccon3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H17ClN6O5/c24-15-3-1-14(2-4-15)12-30-22(32)18(21-28-27-20(13-31)35-21)11-25-23(30)26-16-5-7-17(8-6-16)34-19-9-10-33-29-19/h1-11,31H,12-13H2,(H,25,26) GXYCAYQGZDSUBI-UHFFFAOYSA-N 246745 US9550763, Compound I-399 P2X purinoceptor 3 Homo sapiens 36.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246745 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246745&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823316 376222321 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 491135 CC(C)c1c[nH]\c(=N/c2ccc(Oc3ccc(cn3)C(O)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H23ClN4O4/c1-16(2)22-14-29-26(31(24(22)32)15-17-3-6-19(27)7-4-17)30-20-8-10-21(11-9-20)35-23-12-5-18(13-28-23)25(33)34/h3-14,16H,15H2,1-2H3,(H,29,30)(H,33,34) YRVBNTKAVBZXIJ-UHFFFAOYSA-N 246746 US9550763, Compound I-400 P2X purinoceptor 3 Homo sapiens 16.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=246746 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=246746&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823317 376222322 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490762 CCn1c(=O)cc(Nc2ccc(Oc3cncc(c3)C(N)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H22ClN5O4/c1-2-30-23(32)12-22(31(25(30)34)15-16-3-5-18(26)6-4-16)29-19-7-9-20(10-8-19)35-21-11-17(24(27)33)13-28-14-21/h3-14,29H,2,15H2,1H3,(H2,27,33) MXODRSDHNSANPF-UHFFFAOYSA-N 244253 US9550763, Compound I-001 P2X purinoceptor 3 Homo sapiens 11.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244253 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244253&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 78161083 376221952 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490763 [O-][N+](=O)c1cnc(Nc2ccc(Oc3cccc(n3)C#N)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H15ClN6O4/c24-16-6-4-15(5-7-16)14-29-22(31)20(30(32)33)13-26-23(29)28-17-8-10-19(11-9-17)34-21-3-1-2-18(12-25)27-21/h1-11,13H,14H2,(H,26,28) SPVJIOWHCVYWLS-UHFFFAOYSA-N 244254 US9550763, Compound I-002 P2X purinoceptor 3 Homo sapiens 281 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244254 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244254&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 89745073 376221953 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490764 Nc1c[nH]\c(=N/c2ccc(Oc3cccc(n3)C#N)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H17ClN6O2/c24-16-6-4-15(5-7-16)14-30-22(31)20(26)13-27-23(30)29-17-8-10-19(11-9-17)32-21-3-1-2-18(12-25)28-21/h1-11,13H,14,26H2,(H,27,29) VGRLYDOVHMPQGB-UHFFFAOYSA-N 244255 US9550763, Compound I-003 P2X purinoceptor 3 Homo sapiens 102 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244255 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244255&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823055 376221954 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490765 NC(=O)c1cccc(Oc2ccc(cc2)\N=c2/[nH]cc([N+]([O-])=O)c(=O)n2Cc2ccc(Cl)cc2)n1 InChI=1S/C23H17ClN6O5/c24-15-6-4-14(5-7-15)13-29-22(32)19(30(33)34)12-26-23(29)27-16-8-10-17(11-9-16)35-20-3-1-2-18(28-20)21(25)31/h1-12H,13H2,(H2,25,31)(H,26,27) HJVCOHGIBBJBLO-UHFFFAOYSA-N 244256 US9550763, Compound I-004 P2X purinoceptor 3 Homo sapiens 151 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244256 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244256&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823056 376221955 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490766 COC(=O)Nc1c[nH]\c(=N/c2ccc(Oc3cccc(n3)C#N)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H19ClN6O4/c1-35-25(34)31-21-14-28-24(32(23(21)33)15-16-5-7-17(26)8-6-16)30-18-9-11-20(12-10-18)36-22-4-2-3-19(13-27)29-22/h2-12,14H,15H2,1H3,(H,28,30)(H,31,34) KMIOAIDSMVBEET-UHFFFAOYSA-N 244257 US9550763, Compound I-005 P2X purinoceptor 3 Homo sapiens 17.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244257 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244257&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823057 376221956 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490767 CCC(=O)Nc1c[nH]\c(=N/c2ccc(Oc3cccc(n3)C#N)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H21ClN6O3/c1-2-23(34)32-22-15-29-26(33(25(22)35)16-17-6-8-18(27)9-7-17)31-19-10-12-21(13-11-19)36-24-5-3-4-20(14-28)30-24/h3-13,15H,2,16H2,1H3,(H,29,31)(H,32,34) ZCBXSIJOLIGDJZ-UHFFFAOYSA-N 244258 US9550763, Compound I-006 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244258 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244258&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823058 376221957 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490768 COC(=O)Nc1c[nH]\c(=N/c2ccc(Oc3cccc(n3)C(N)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H21ClN6O5/c1-36-25(35)31-20-13-28-24(32(23(20)34)14-15-5-7-16(26)8-6-15)29-17-9-11-18(12-10-17)37-21-4-2-3-19(30-21)22(27)33/h2-13H,14H2,1H3,(H2,27,33)(H,28,29)(H,31,35) JXVKIRYVNXWAHL-UHFFFAOYSA-N 244259 US9550763, Compound I-007 P2X purinoceptor 3 Homo sapiens 23.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244259 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244259&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823059 376221958 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490769 CCn1c(=O)cc(Nc2ccc(Oc3cccc(c3)C(=O)OC)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C27H24ClN3O5/c1-3-30-25(32)16-24(31(27(30)34)17-18-7-9-20(28)10-8-18)29-21-11-13-22(14-12-21)36-23-6-4-5-19(15-23)26(33)35-2/h4-16,29H,3,17H2,1-2H3 LUELLIGLCKDWPZ-UHFFFAOYSA-N 244260 US9550763, Compound I-008 P2X purinoceptor 3 Homo sapiens 38.0 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244260 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244260&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823060 376221959 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490770 CCn1c(=O)cc(Nc2ccc(Oc3cccc(n3)C#N)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H20ClN5O3/c1-2-30-24(32)14-22(31(25(30)33)16-17-6-8-18(26)9-7-17)28-19-10-12-21(13-11-19)34-23-5-3-4-20(15-27)29-23/h3-14,28H,2,16H2,1H3 OSEQDQJARFPYIG-UHFFFAOYSA-N 244261 US9550763, Compound I-009 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244261 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244261&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823061 376221960 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490771 CCOC(=O)c1cnc(Oc2ccc(Nc3cc(=O)n(CC)c(=O)n3Cc3ccc(Cl)cc3)cc2)s1 InChI=1S/C25H23ClN4O5S/c1-3-29-22(31)13-21(30(25(29)33)15-16-5-7-17(26)8-6-16)28-18-9-11-19(12-10-18)35-24-27-14-20(36-24)23(32)34-4-2/h5-14,28H,3-4,15H2,1-2H3 PQXOZSYPZIESDL-UHFFFAOYSA-N 244262 US9550763, Compound I-010 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244262 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244262&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823062 376221961 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490772 CCn1c(=O)cc(Nc2ccc(Oc3cccc(n3)C#N)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H19ClFN5O3/c1-2-31-24(33)13-22(32(25(31)34)15-16-6-8-17(26)9-7-16)29-18-10-11-21(20(27)12-18)35-23-5-3-4-19(14-28)30-23/h3-13,29H,2,15H2,1H3 IOMJYQVTRGSFBM-UHFFFAOYSA-N 244263 US9550763, Compound I-011 P2X purinoceptor 3 Homo sapiens 2.00 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244263 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244263&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823063 376221962 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 490773 CCn1c(=O)cc(Nc2ccc(Oc3cccc(n3)C#N)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H22ClN5O3/c1-3-31-25(33)14-23(32(26(31)34)16-18-7-9-19(27)10-8-18)29-20-11-12-22(17(2)13-20)35-24-6-4-5-21(15-28)30-24/h4-14,29H,3,16H2,1-2H3 BZCUHRLYHPWHKT-UHFFFAOYSA-N 244264 US9550763, Compound I-012 P2X purinoceptor 3 Homo sapiens 2.00 7.5 US Patent 10.7270/Q2V126TQ aid1795162 US9550763 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244264 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244264&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134823064 376221963 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513527 COC(=O)[C@H](C)[C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(F)cn3)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O 271500 US10065941, Compound I-001::US9732060, Compound I-001 P2X purinoceptor 3 Homo sapiens 44.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271500 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271500&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752166 378153328 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513528 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(F)cn3)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271501 US10065941, Compound I-002::US9732060, Compound I-002 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271501 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271501&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752228 378153329 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513529 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(F)cn3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C27H25ClFN5O5/c1-27(2,23(35)38-3)16-34-25(36)32-24(33(26(34)37)15-17-4-6-18(28)7-5-17)31-20-9-11-21(12-10-20)39-22-13-8-19(29)14-30-22/h4-14H,15-16H2,1-3H3,(H,31,32,36) IKHMJSCTIDRHBS-UHFFFAOYSA-N 271502 US10065941, Compound I-003::US9732060, Compound I-003 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271502 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271502&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752218 378153330 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513530 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(Cl)cn3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C27H25Cl2N5O5/c1-27(2,23(35)38-3)16-34-25(36)32-24(33(26(34)37)15-17-4-6-18(28)7-5-17)31-20-9-11-21(12-10-20)39-22-13-8-19(29)14-30-22/h4-14H,15-16H2,1-3H3,(H,31,32,36) ILATUGAAQLAULT-UHFFFAOYSA-N 271503 US10065941, Compound I-004::US9732060, Compound I-004 P2X purinoceptor 3 Homo sapiens 14.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271503 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271503&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752187 378153331 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513531 CC(C)(Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(F)cn3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O InChI=1S/C26H23ClFN5O5/c1-26(2,22(34)35)15-33-24(36)31-23(32(25(33)37)14-16-3-5-17(27)6-4-16)30-19-8-10-20(11-9-19)38-21-12-7-18(28)13-29-21/h3-13H,14-15H2,1-2H3,(H,34,35)(H,30,31,36) DEUOHZRZNWVIJH-UHFFFAOYSA-N 271504 US10065941, Compound I-005::US9732060, Compound I-005 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271504 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271504&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752167 378153332 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513532 CC(C)(Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(Cl)cn3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O InChI=1S/C26H23Cl2N5O5/c1-26(2,22(34)35)15-33-24(36)31-23(32(25(33)37)14-16-3-5-17(27)6-4-16)30-19-8-10-20(11-9-19)38-21-12-7-18(28)13-29-21/h3-13H,14-15H2,1-2H3,(H,34,35)(H,30,31,36) UXDHDBKZQYVJSB-UHFFFAOYSA-N 271505 US10065941, Compound I-006::US9732060, Compound I-006 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271505 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271505&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752326 378153333 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513533 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ncccc3F)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C27H25ClFN5O5/c1-27(2,23(35)38-3)16-34-25(36)32-24(33(26(34)37)15-17-6-8-18(28)9-7-17)31-19-10-12-20(13-11-19)39-22-21(29)5-4-14-30-22/h4-14H,15-16H2,1-3H3,(H,31,32,36) JZFORMIPMPCUTA-UHFFFAOYSA-N 271506 US10065941, Compound I-007::US9732060, Compound I-007 P2X purinoceptor 3 Homo sapiens 9.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271506 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271506&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752318 378153334 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513534 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(F)n3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C27H25ClFN5O5/c1-27(2,23(35)38-3)16-34-25(36)32-24(33(26(34)37)15-17-7-9-18(28)10-8-17)30-19-11-13-20(14-12-19)39-22-6-4-5-21(29)31-22/h4-14H,15-16H2,1-3H3,(H,30,32,36) DSIJTPSJCQDTAN-UHFFFAOYSA-N 271507 US10065941, Compound I-008::US9732060, Compound I-008 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271507 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271507&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752315 378153335 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513535 CC(C)(Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ncccc3F)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O InChI=1S/C26H23ClFN5O5/c1-26(2,22(34)35)15-33-24(36)31-23(32(25(33)37)14-16-5-7-17(27)8-6-16)30-18-9-11-19(12-10-18)38-21-20(28)4-3-13-29-21/h3-13H,14-15H2,1-2H3,(H,34,35)(H,30,31,36) GKDSFPBNRMQVRT-UHFFFAOYSA-N 271508 US10065941, Compound I-009::US9732060, Compound I-009 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271508 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271508&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295394 378153336 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513536 CC(C)(Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(F)n3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O InChI=1S/C26H23ClFN5O5/c1-26(2,22(34)35)15-33-24(36)31-23(32(25(33)37)14-16-6-8-17(27)9-7-16)29-18-10-12-19(13-11-18)38-21-5-3-4-20(28)30-21/h3-13H,14-15H2,1-2H3,(H,34,35)(H,29,31,36) OOQKMULDJFIQNR-UHFFFAOYSA-N 271509 US10065941, Compound I-010::US9732060, Compound I-010 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271509 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271509&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752308 378153337 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513537 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(Cl)n3)cc2)n(Cc2ccc(Cl)cc2)c1=O 271510 US10065941, Compound I-011::US9732060, Compound I-011 P2X purinoceptor 3 Homo sapiens 18.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271510 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271510&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295395 378153338 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513538 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(Cl)n3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C27H25Cl2N5O5/c1-27(2,23(35)38-3)16-34-25(36)32-24(33(26(34)37)15-17-7-9-18(28)10-8-17)30-19-11-13-20(14-12-19)39-22-6-4-5-21(29)31-22/h4-14H,15-16H2,1-3H3,(H,30,32,36) MAAXYLWWFYPLSU-UHFFFAOYSA-N 271511 US10065941, Compound I-012::US9732060, Compound I-012 P2X purinoceptor 3 Homo sapiens 25.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271511 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271511&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295396 378153339 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513539 COC(=O)[C@H](C)[C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(Cl)n3)cc2)n(Cc2ccc(Cl)cc2)c1=O 271512 US10065941, Compound I-013::US9732060, Compound I-013 P2X purinoceptor 3 Homo sapiens 58.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271512 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271512&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295397 378153340 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513540 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(Cl)n3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271513 US10065941, Compound I-014::US9732060, Compound I-014 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271513 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271513&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 86292818 378153341 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513541 CC(C)(Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(Cl)n3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O InChI=1S/C26H23Cl2N5O5/c1-26(2,22(34)35)15-33-24(36)31-23(32(25(33)37)14-16-6-8-17(27)9-7-16)29-18-10-12-19(13-11-18)38-21-5-3-4-20(28)30-21/h3-13H,14-15H2,1-2H3,(H,34,35)(H,29,31,36) PBXBAMBZPWHRPG-UHFFFAOYSA-N 271514 US10065941, Compound I-015::US9732060, Compound I-015 P2X purinoceptor 3 Homo sapiens 9.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271514 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271514&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752280 378153342 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513542 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(Cl)n3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271515 US10065941, Compound I-016::US9732060, Compound I-016 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271515 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271515&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752080 378153343 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513543 OC(=O)C1(Cn2c(=O)[nH]\c(=N/c3ccc(Oc4cccc(F)n4)cc3)n(Cc3ccc(Cl)cc3)c2=O)CC1 InChI=1S/C26H21ClFN5O5/c27-17-6-4-16(5-7-17)14-32-23(31-24(36)33(25(32)37)15-26(12-13-26)22(34)35)29-18-8-10-19(11-9-18)38-21-3-1-2-20(28)30-21/h1-11H,12-15H2,(H,34,35)(H,29,31,36) NIVAFFJLOOMGLF-UHFFFAOYSA-N 271516 US10065941, Compound I-017::US9732060, Compound I-017 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271516 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271516&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752077 378153344 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513544 OC(=O)C1(Cn2c(=O)[nH]\c(=N/c3ccc(Oc4ccc(F)cn4)cc3)n(Cc3ccc(Cl)cc3)c2=O)CC1 InChI=1S/C26H21ClFN5O5/c27-17-3-1-16(2-4-17)14-32-23(31-24(36)33(25(32)37)15-26(11-12-26)22(34)35)30-19-6-8-20(9-7-19)38-21-10-5-18(28)13-29-21/h1-10,13H,11-12,14-15H2,(H,34,35)(H,30,31,36) XTVJZQVEKPCHOX-UHFFFAOYSA-N 271517 US10065941, Compound I-018::US9732060, Compound I-018 P2X purinoceptor 3 Homo sapiens 12.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271517 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271517&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752087 378153345 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513545 OC(=O)[C@H]1C[C@@H](C1)n1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(F)cn3)cc2)n(Cc2ccc(Cl)cc2)c1=O 271518 US10065941, Compound I-019::US9732060, Compound I-019 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271518 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271518&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752079 378153346 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513546 OC(=O)[C@H]1C[C@H](C1)n1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(F)cn3)cc2)n(Cc2ccc(Cl)cc2)c1=O 271519 US10065941, Compound I-020::US9732060, Compound I-020 P2X purinoceptor 3 Homo sapiens 9.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271519 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271519&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752079 378153347 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513547 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(OC(F)F)cn3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C28H26ClF2N5O6/c1-28(2,23(37)40-3)16-36-26(38)34-25(35(27(36)39)15-17-4-6-18(29)7-5-17)33-19-8-10-20(11-9-19)41-22-13-12-21(14-32-22)42-24(30)31/h4-14,24H,15-16H2,1-3H3,(H,33,34,38) JGPMZUHKUJEZCW-UHFFFAOYSA-N 271520 US10065941, Compound I-021::US9732060, Compound I-021 P2X purinoceptor 3 Homo sapiens 25.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271520 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271520&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752096 378153348 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513548 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(OC(F)F)cn3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271521 US10065941, Compound I-022::US9732060, Compound I-022 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271521 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271521&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121285500 378153349 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513549 CC(C)(Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(OC(F)F)cn3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O InChI=1S/C27H24ClF2N5O6/c1-27(2,22(36)37)15-35-25(38)33-24(34(26(35)39)14-16-3-5-17(28)6-4-16)32-18-7-9-19(10-8-18)40-21-12-11-20(13-31-21)41-23(29)30/h3-13,23H,14-15H2,1-2H3,(H,36,37)(H,32,33,38) JSNOAMVAKYGROY-UHFFFAOYSA-N 271522 US10065941, Compound I-023::US9732060, Compound I-023 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271522 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271522&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295398 378153350 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513550 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ncccc3F)cc2)n(Cc2ccc(F)cc2F)c1=O 271523 US10065941, Compound I-024::US9732060, Compound I-024 P2X purinoceptor 3 Homo sapiens 34.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271523 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271523&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752097 378153351 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513551 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(F)cn3)cc2)n(Cc2ccc(F)cc2F)c1=O 271524 US10065941, Compound I-025::US9732060, Compound I-025 P2X purinoceptor 3 Homo sapiens 23.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271524 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271524&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752089 378153352 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513552 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(F)n3)cc2)n(Cc2ccc(F)cc2F)c1=O 271525 US10065941, Compound I-026::US9732060, Compound I-026 P2X purinoceptor 3 Homo sapiens 17.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271525 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271525&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752250 378153353 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513553 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ncccc3F)cc2)n(Cc2ccc(F)cc2F)c1=O)C(O)=O 271526 US10065941, Compound I-027::US9732060, Compound I-027 P2X purinoceptor 3 Homo sapiens 39.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271526 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271526&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752253 378153354 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513554 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(F)cn3)cc2)n(Cc2ccc(F)cc2F)c1=O)C(O)=O 271527 US10065941, Compound I-028::US9732060, Compound I-028 P2X purinoceptor 3 Homo sapiens 20.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271527 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271527&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752249 378153355 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513555 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(F)n3)cc2)n(Cc2ccc(F)cc2F)c1=O)C(O)=O 271528 US10065941, Compound I-029::US9732060, Compound I-029 P2X purinoceptor 3 Homo sapiens 14.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271528 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271528&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752254 378153356 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513556 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ncccc3C(F)(F)F)cc2)n(Cc2ccc(Cl)cc2)c1=O 271529 US10065941, Compound I-030::US9732060, Compound I-030 P2X purinoceptor 3 Homo sapiens 176 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271529 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271529&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752255 378153357 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513557 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ncccc3C(F)(F)F)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C28H25ClF3N5O5/c1-27(2,23(38)41-3)16-37-25(39)35-24(36(26(37)40)15-17-6-8-18(29)9-7-17)34-19-10-12-20(13-11-19)42-22-21(28(30,31)32)5-4-14-33-22/h4-14H,15-16H2,1-3H3,(H,34,35,39) DNXMRCVOSPXHJA-UHFFFAOYSA-N 271530 US10065941, Compound I-031::US9732060, Compound I-031 P2X purinoceptor 3 Homo sapiens 199 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271530 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271530&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295399 378153358 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513558 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ncccc3C(F)(F)F)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271531 US10065941, Compound I-032::US9732060, Compound I-032 P2X purinoceptor 3 Homo sapiens 11.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271531 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271531&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752261 378153359 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513559 CC(C)(Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ncccc3C(F)(F)F)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O InChI=1S/C27H23ClF3N5O5/c1-26(2,22(37)38)15-36-24(39)34-23(35(25(36)40)14-16-5-7-17(28)8-6-16)33-18-9-11-19(12-10-18)41-21-20(27(29,30)31)4-3-13-32-21/h3-13H,14-15H2,1-2H3,(H,37,38)(H,33,34,39) BTJJWEQWDHOPAU-UHFFFAOYSA-N 271532 US10065941, Compound I-033::US9732060, Compound I-033 P2X purinoceptor 3 Homo sapiens 23.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271532 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271532&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295400 378153360 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513560 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(cn3)C(F)(F)F)cc2)n(Cc2ccc(C)cc2)c1=O 271533 US10065941, Compound I-034::US9732060, Compound I-034 P2X purinoceptor 3 Homo sapiens 9.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271533&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752262 378153361 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513561 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(n3)C(F)(F)F)cc2)n(Cc2ccc(C)cc2)c1=O 271534 US10065941, Compound I-035::US9732060, Compound I-035 P2X purinoceptor 3 Homo sapiens 12.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271534 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271534&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752282 378153362 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513562 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(F)cn3)cc2)n(Cc2ccc(C)cc2)c1=O 271535 US10065941, Compound I-036::US10065941, Compound I-129::US9732060, Compound I-129 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271535 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271535&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752331 378153363 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513563 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(F)cn3)cc2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C28H28FN5O5/c1-18-5-7-19(8-6-18)16-33-25(32-26(36)34(27(33)37)17-28(2,3)24(35)38-4)31-21-10-12-22(13-11-21)39-23-14-9-20(29)15-30-23/h5-15H,16-17H2,1-4H3,(H,31,32,36) UVJOKJWCJVBVAH-UHFFFAOYSA-N 271536 US10065941, Compound I-037::US9732060, Compound I-037 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271536 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271536&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752333 378153364 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513564 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(cn3)C(F)(F)F)cc2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 271537 US10065941, Compound I-038::US9732060, Compound I-038 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271537 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271537&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752332 378153365 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513565 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(n3)C(F)(F)F)cc2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 271538 US10065941, Compound I-039::US9732060, Compound I-039 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271538 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271538&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752334 378153366 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513566 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(F)cn3)cc2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 271539 US10065941, Compound I-040::US10065941, Compound I-130::US9732060, Compound I-130 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271539 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271539&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752335 378153367 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513567 Cc1ccc(Cn2c(=O)n(CC(C)(C)C(O)=O)c(=O)[nH]\c2=N/c2ccc(Oc3ccc(F)cn3)cc2)cc1 InChI=1S/C27H26FN5O5/c1-17-4-6-18(7-5-17)15-32-24(31-25(36)33(26(32)37)16-27(2,3)23(34)35)30-20-9-11-21(12-10-20)38-22-13-8-19(28)14-29-22/h4-14H,15-16H2,1-3H3,(H,34,35)(H,30,31,36) GXGCGKGZBZYUGT-UHFFFAOYSA-N 271540 US10065941, Compound I-041::US9732060, Compound I-041 P2X purinoceptor 3 Homo sapiens 9.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271540 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271540&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752305 378153368 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513568 OCC1(Cn2c(=O)[nH]\c(=N/c3ccc(Oc4cccc(F)n4)cc3)n(Cc3ccc(Cl)cc3)c2=O)COC1 InChI=1S/C26H23ClFN5O5/c27-18-6-4-17(5-7-18)12-32-23(31-24(35)33(25(32)36)13-26(14-34)15-37-16-26)29-19-8-10-20(11-9-19)38-22-3-1-2-21(28)30-22/h1-11,34H,12-16H2,(H,29,31,35) VTTBVJRGDXWJQC-UHFFFAOYSA-N 271541 US10065941, Compound I-042::US9732060, Compound I-042 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271541 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271541&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 86567205 378153369 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513569 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ncccc3OC(F)F)cc2)n(Cc2ccc(Cl)cc2)c1=O 271542 US10065941, Compound I-043::US9732060, Compound I-043 P2X purinoceptor 3 Homo sapiens 117 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271542 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271542&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295401 378153370 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513570 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ncccc3OC(F)F)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271543 US10065941, Compound I-044::US9732060, Compound I-044 P2X purinoceptor 3 Homo sapiens 26.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271543 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271543&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295402 378153371 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513571 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ncccc3C#N)cc2)n(Cc2ccc(Cl)cc2)c1=O 271544 US10065941, Compound I-045::US9732060, Compound I-045 P2X purinoceptor 3 Homo sapiens 19.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271544 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271544&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752324 378153372 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513572 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ncccc3C#N)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C28H25ClN6O5/c1-28(2,24(36)39-3)17-35-26(37)33-25(34(27(35)38)16-18-6-8-20(29)9-7-18)32-21-10-12-22(13-11-21)40-23-19(15-30)5-4-14-31-23/h4-14H,16-17H2,1-3H3,(H,32,33,37) KHGVWZBOVSZOOI-UHFFFAOYSA-N 271545 US10065941, Compound I-046::US9732060, Compound I-046 P2X purinoceptor 3 Homo sapiens 19.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271545 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271545&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295403 378153373 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513573 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ncccc3C#N)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271546 US10065941, Compound I-047::US9732060, Compound I-047 P2X purinoceptor 3 Homo sapiens 22.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271546 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271546&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752316 378153374 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513574 CC(C)(Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ncccc3C#N)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O InChI=1S/C27H23ClN6O5/c1-27(2,23(35)36)16-34-25(37)32-24(33(26(34)38)15-17-5-7-19(28)8-6-17)31-20-9-11-21(12-10-20)39-22-18(14-29)4-3-13-30-22/h3-13H,15-16H2,1-2H3,(H,35,36)(H,31,32,37) SSHDQQIDZMBXEA-UHFFFAOYSA-N 271547 US10065941, Compound I-048::US9732060, Compound I-048 P2X purinoceptor 3 Homo sapiens 30.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271547 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271547&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295404 378153375 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513575 OC(=O)C1(Cn2c(=O)[nH]\c(=N/c3ccc(Oc4cccc(F)n4)cc3)n(Cc3ccc(Cl)cc3)c2=O)COC1 InChI=1S/C26H21ClFN5O6/c27-17-6-4-16(5-7-17)12-32-23(31-24(36)33(25(32)37)13-26(22(34)35)14-38-15-26)29-18-8-10-19(11-9-18)39-21-3-1-2-20(28)30-21/h1-11H,12-15H2,(H,34,35)(H,29,31,36) OFCLQVOIAILOKU-UHFFFAOYSA-N 271548 US10065941, Compound I-049::US9732060, Compound I-049 P2X purinoceptor 3 Homo sapiens 15.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271548 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271548&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752309 378153376 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513576 OC(=O)C1(Cn2c(=O)[nH]\c(=N/c3ccc(Oc4ncccc4F)cc3)n(Cc3ccc(Cl)cc3)c2=O)COC1 InChI=1S/C26H21ClFN5O6/c27-17-5-3-16(4-6-17)12-32-23(31-24(36)33(25(32)37)13-26(22(34)35)14-38-15-26)30-18-7-9-19(10-8-18)39-21-20(28)2-1-11-29-21/h1-11H,12-15H2,(H,34,35)(H,30,31,36) MNQIYNSUTGJBAX-UHFFFAOYSA-N 271549 US10065941, Compound I-050::US9732060, Compound I-050 P2X purinoceptor 3 Homo sapiens 28.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271549 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271549&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752311 378153377 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513577 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(C)cn3)cc2)n(Cc2ccc(Cl)cc2)c1=O 271550 US10065941, Compound I-051::US9732060, Compound I-051 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271550 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271550&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752274 378153378 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513578 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ncccc3F)cc2)n(Cc2ccc(C)cc2)c1=O 271551 US10065941, Compound I-052::US9732060, Compound I-052 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271551 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271551&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752263 378153379 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513579 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(F)n3)cc2)n(Cc2ccc(C)cc2)c1=O 271552 US10065941, Compound I-053::US9732060, Compound I-053 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271552 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271552&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295405 378153380 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513580 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(C)cn3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271553 US10065941, Compound I-054::US9732060, Compound I-054 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271553 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271553&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752283 378153381 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513581 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(C)cn3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C28H28ClN5O5/c1-18-5-14-23(30-15-18)39-22-12-10-21(11-13-22)31-25-32-26(36)34(17-28(2,3)24(35)38-4)27(37)33(25)16-19-6-8-20(29)9-7-19/h5-15H,16-17H2,1-4H3,(H,31,32,36) AALPGRJMGHQTMB-UHFFFAOYSA-N 271554 US10065941, Compound I-055::US9732060, Compound I-055 P2X purinoceptor 3 Homo sapiens 9.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271554 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271554&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752284 378153382 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513582 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ncccc3F)cc2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 271555 US10065941, Compound I-056::US9732060, Compound I-056 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271555 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271555&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752329 378153383 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513583 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(F)n3)cc2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 271556 US10065941, Compound I-057::US9732060, Compound I-057 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271556 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271556&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752319 378153384 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513584 Cc1ccc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n2Cc2ccc(Cl)cc2)nc1 InChI=1S/C27H26ClN5O5/c1-17-4-13-22(29-14-17)38-21-11-9-20(10-12-21)30-24-31-25(36)33(16-27(2,3)23(34)35)26(37)32(24)15-18-5-7-19(28)8-6-18/h4-14H,15-16H2,1-3H3,(H,34,35)(H,30,31,36) VKWDANGMJGKQJB-UHFFFAOYSA-N 271557 US10065941, Compound I-058::US9732060, Compound I-058 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271557 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271557&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752330 378153385 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513585 OC(=O)C1(Cn2c(=O)[nH]\c(=N/c3ccc(Oc4ccc(F)cn4)cc3)n(Cc3ccc(Cl)cc3)c2=O)COC1 InChI=1S/C26H21ClFN5O6/c27-17-3-1-16(2-4-17)12-32-23(31-24(36)33(25(32)37)13-26(22(34)35)14-38-15-26)30-19-6-8-20(9-7-19)39-21-10-5-18(28)11-29-21/h1-11H,12-15H2,(H,34,35)(H,30,31,36) IVCYQHDQRAIRRG-UHFFFAOYSA-N 271558 US10065941, Compound I-059::US9732060, Compound I-059 P2X purinoceptor 3 Homo sapiens 16.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271558 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271558&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752320 378153386 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513586 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cc(Cl)ccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O 271559 US10065941, Compound I-060::US9732060, Compound I-060 P2X purinoceptor 3 Homo sapiens 24.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271559 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271559&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295406 378153387 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513587 CCOC(=O)[C@H]1C[C@@H](C1)n1c(=O)[nH]\c(=N/c2ccc(Oc3ncccc3F)cc2)n(Cc2ccc(Cl)cc2)c1=O 271560 US10065941, Compound I-061::US9732060, Compound I-061 P2X purinoceptor 3 Homo sapiens 62.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271560 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271560&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752219 378153388 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513588 CCOC(=O)[C@H]1C[C@H](C1)n1c(=O)[nH]\c(=N/c2ccc(Oc3ncccc3F)cc2)n(Cc2ccc(Cl)cc2)c1=O 271561 US10065941, Compound I-062::US9732060, Compound I-062 P2X purinoceptor 3 Homo sapiens 31.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271561 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271561&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752219 378153389 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513589 OC(=O)[C@H]1C[C@@H](C1)n1c(=O)[nH]\c(=N/c2ccc(Oc3ncccc3F)cc2)n(Cc2ccc(Cl)cc2)c1=O 271562 US10065941, Compound I-063::US9732060, Compound I-063 P2X purinoceptor 3 Homo sapiens 9.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271562 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271562&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295407 378153390 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513590 OC(=O)[C@H]1C[C@H](C1)n1c(=O)[nH]\c(=N/c2ccc(Oc3ncccc3F)cc2)n(Cc2ccc(Cl)cc2)c1=O 271563 US10065941, Compound I-064::US9732060, Compound I-064 P2X purinoceptor 3 Homo sapiens 10.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271563 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271563&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295407 378153391 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513591 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cc(Cl)ccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271564 US10065941, Compound I-065::US9732060, Compound I-065 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271564 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271564&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295408 378153392 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513592 CCOC(=O)C1(Cn2c(=O)[nH]\c(=N/c3ccc(Oc4ncccc4F)cc3)n(Cc3ccc(Cl)cc3)c2=O)CC1 InChI=1S/C28H25ClFN5O5/c1-2-39-24(36)28(13-14-28)17-35-26(37)33-25(34(27(35)38)16-18-5-7-19(29)8-6-18)32-20-9-11-21(12-10-20)40-23-22(30)4-3-15-31-23/h3-12,15H,2,13-14,16-17H2,1H3,(H,32,33,37) LPJSFDIHWQRGJR-UHFFFAOYSA-N 271565 US10065941, Compound I-066::US9732060, Compound I-066 P2X purinoceptor 3 Homo sapiens 15.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271565 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271565&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752185 378153393 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513593 OC(=O)C1(Cn2c(=O)[nH]\c(=N/c3ccc(Oc4ncccc4F)cc3)n(Cc3ccc(Cl)cc3)c2=O)CC1 InChI=1S/C26H21ClFN5O5/c27-17-5-3-16(4-6-17)14-32-23(31-24(36)33(25(32)37)15-26(11-12-26)22(34)35)30-18-7-9-19(10-8-18)38-21-20(28)2-1-13-29-21/h1-10,13H,11-12,14-15H2,(H,34,35)(H,30,31,36) IIGGPTNKMMORJQ-UHFFFAOYSA-N 271566 US10065941, Compound I-067::US9732060, Compound I-067 P2X purinoceptor 3 Homo sapiens 11.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271566 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271566&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752231 378153394 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513594 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cc(F)ccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O 271567 US10065941, Compound I-068::US9732060, Compound I-068 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271567 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271567&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752235 378153395 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513595 COc1ccnc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n2Cc2ccc(Cl)cc2)c1 271568 US10065941, Compound I-069::US9732060, Compound I-069 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271568 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271568&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752209 378153396 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513596 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cc(F)ccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271569 US10065941, Compound I-070::US9732060, Compound I-070 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271569 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271569&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752201 378153397 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513597 COC(=O)[C@H](C)[C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(OC(F)F)cn3)cc2)n(Cc2ccc(Cl)cc2)c1=O 271570 US10065941, Compound I-071::US9732060, Compound I-071 P2X purinoceptor 3 Homo sapiens 38.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271570 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271570&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295409 378153398 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513598 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(OC(F)F)cn3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271571 US10065941, Compound I-072::US9732060, Compound I-072 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271571 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271571&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295410 378153399 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513599 COC(=O)[C@H](C)[C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(C)cn3)cc2)n(Cc2ccc(Cl)cc2)c1=O 271572 US10065941, Compound I-073::US9732060, Compound I-073 P2X purinoceptor 3 Homo sapiens 15.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271572 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271572&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752227 378153400 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513600 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(C)cn3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271573 US10065941, Compound I-074::US9732060, Compound I-074 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271573 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271573&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752178 378153401 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513601 COC(=O)[C@H](C)[C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3cc(ccn3)C#N)cc2)n(Cc2ccc(Cl)cc2)c1=O 271574 US10065941, Compound I-075::US9732060, Compound I-075 P2X purinoceptor 3 Homo sapiens 21.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271574 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271574&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752217 378153402 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513602 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cc(C)ccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O 271575 US10065941, Compound I-076::US9732060, Compound I-076 P2X purinoceptor 3 Homo sapiens 22.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271575 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271575&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295411 378153403 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513603 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ncccc3C)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271576 US10065941, Compound I-077::US9732060, Compound I-077 P2X purinoceptor 3 Homo sapiens 10.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271576 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271576&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295412 378153404 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513604 Cc1cccnc1Oc1ccc(cc1)\N=c1/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C27H26ClN5O5/c1-17-5-4-14-29-22(17)38-21-12-10-20(11-13-21)30-24-31-25(36)33(16-27(2,3)23(34)35)26(37)32(24)15-18-6-8-19(28)9-7-18/h4-14H,15-16H2,1-3H3,(H,34,35)(H,30,31,36) DITAJEZEBFWEFI-UHFFFAOYSA-N 271577 US10065941, Compound I-078::US9732060, Compound I-078 P2X purinoceptor 3 Homo sapiens 19.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271577 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271577&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752075 378153405 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513605 COc1ccc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n2Cc2ccc(Cl)cc2)nc1 271578 US10065941, Compound I-079::US9732060, Compound I-079 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271578 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271578&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752076 378153406 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513606 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cc(C)ccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271579 US10065941, Compound I-080::US9732060, Compound I-080 P2X purinoceptor 3 Homo sapiens 10.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271579 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271579&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295414 378153407 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513607 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cc(Cl)ccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C27H25Cl2N5O5/c1-27(2,23(35)38-3)16-34-25(36)32-24(33(26(34)37)15-17-4-6-18(28)7-5-17)31-20-8-10-21(11-9-20)39-22-14-19(29)12-13-30-22/h4-14H,15-16H2,1-3H3,(H,31,32,36) HFEJVCAJTAREHJ-UHFFFAOYSA-N 271580 US10065941, Compound I-081::US9732060, Compound I-081 P2X purinoceptor 3 Homo sapiens 38.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271580 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271580&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295413 378153408 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513608 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cc(ccn3)C(F)(F)F)cc2)n(Cc2ccc(Cl)cc2)c1=O 271581 US10065941, Compound I-082::US9732060, Compound I-082 P2X purinoceptor 3 Homo sapiens 112 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271581 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271581&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752323 378153409 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513609 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(CO)cn3)cc2)n(Cc2ccc(Cl)cc2)c1=O 271582 US10065941, Compound I-083::US9732060, Compound I-083 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271582 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271582&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295416 378153410 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513610 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(CO)cn3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271583 US10065941, Compound I-084::US9732060, Compound I-084 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271583 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271583&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295415 378153411 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513611 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cc(ccn3)C(F)(F)F)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C28H25ClF3N5O5/c1-27(2,23(38)41-3)16-37-25(39)35-24(36(26(37)40)15-17-4-6-19(29)7-5-17)34-20-8-10-21(11-9-20)42-22-14-18(12-13-33-22)28(30,31)32/h4-14H,15-16H2,1-3H3,(H,34,35,39) XFDSYLNTCQUHNU-UHFFFAOYSA-N 271584 US10065941, Compound I-085::US9732060, Compound I-085 P2X purinoceptor 3 Homo sapiens 225 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271584 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271584&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752340 378153412 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513612 CC(C)(Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cc(Cl)ccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O InChI=1S/C26H23Cl2N5O5/c1-26(2,22(34)35)15-33-24(36)31-23(32(25(33)37)14-16-3-5-17(27)6-4-16)30-19-7-9-20(10-8-19)38-21-13-18(28)11-12-29-21/h3-13H,14-15H2,1-2H3,(H,34,35)(H,30,31,36) ZBNIESORYSQSQU-UHFFFAOYSA-N 271585 US10065941, Compound I-086::US9732060, Compound I-086 P2X purinoceptor 3 Homo sapiens 33.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271585 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271585&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295417 378153413 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513613 COC(=O)[C@H](C)[C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3cc(Cl)ccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O 271586 US10065941, Compound I-087::US9732060, Compound I-087 P2X purinoceptor 3 Homo sapiens 107 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271586 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271586&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295418 378153414 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513614 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cc(ccn3)C(F)(F)F)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271587 US10065941, Compound I-088::US9732060, Compound I-088 P2X purinoceptor 3 Homo sapiens 15.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271587 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271587&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295419 378153415 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513615 CCOC(=O)C[C@H](O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(F)cn3)cc2)n(Cc2ccc(Cl)cc2)c1=O 271588 US10065941, Compound I-089::US9732060, Compound I-089 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271588 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271588&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752184 378153416 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513616 O[C@@H](CC(O)=O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(F)cn3)cc2)n(Cc2ccc(Cl)cc2)c1=O 271589 US10065941, Compound I-090::US9732060, Compound I-090 P2X purinoceptor 3 Homo sapiens 72.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271589 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271589&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295420 378153417 C03834 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513617 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3cc(Cl)ccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271590 US10065941, Compound I-091::US9732060, Compound I-091 P2X purinoceptor 3 Homo sapiens 10.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271590 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271590&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295421 378153418 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513618 CC(C)(Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cc(ccn3)C(F)(F)F)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O InChI=1S/C27H23ClF3N5O5/c1-26(2,22(37)38)15-36-24(39)34-23(35(25(36)40)14-16-3-5-18(28)6-4-16)33-19-7-9-20(10-8-19)41-21-13-17(11-12-32-21)27(29,30)31/h3-13H,14-15H2,1-2H3,(H,37,38)(H,33,34,39) BPMHGKNWDOVNQX-UHFFFAOYSA-N 271591 US10065941, Compound I-092::US9732060, Compound I-092 P2X purinoceptor 3 Homo sapiens 68.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271591 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271591&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752257 378153419 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513619 COc1ccc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n2Cc2ccc(Cl)cc2)nc1 InChI=1S/C27H26ClN5O6/c1-27(2,23(34)35)16-33-25(36)31-24(32(26(33)37)15-17-4-6-18(28)7-5-17)30-19-8-10-20(11-9-19)39-22-13-12-21(38-3)14-29-22/h4-14H,15-16H2,1-3H3,(H,34,35)(H,30,31,36) FAUNSQBLHRELKM-UHFFFAOYSA-N 271592 US10065941, Compound I-093::US9732060, Compound I-093 P2X purinoceptor 3 Homo sapiens 16.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271592 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271592&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752256 378153420 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513620 COc1ccc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n([C@@H](C)[C@@H](C)C(O)=O)c(=O)n2Cc2ccc(Cl)cc2)nc1 271593 US10065941, Compound I-094::US9732060, Compound I-094 P2X purinoceptor 3 Homo sapiens 11.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271593 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271593&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752258 378153421 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513621 COC(=O)[C@H](C)[C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3ncccc3F)cc2)n(Cc2ccc(C)cc2)c1=O 271594 US10065941, Compound I-095::US9732060, Compound I-095 P2X purinoceptor 3 Homo sapiens 9.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271594 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271594&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295422 378153422 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513622 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3ncccc3F)cc2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 271595 US10065941, Compound I-096::US9732060, Compound I-096 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271595 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271595&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752321 378153423 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513623 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(Cl)cn3)cc2)n(Cc2ccc(C)cc2)c1=O 271596 US10065941, Compound I-097::US9732060, Compound I-097 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271596 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271596&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752312 378153424 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513624 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(Cl)cn3)cc2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C28H28ClN5O5/c1-18-5-7-19(8-6-18)16-33-25(32-26(36)34(27(33)37)17-28(2,3)24(35)38-4)31-21-10-12-22(13-11-21)39-23-14-9-20(29)15-30-23/h5-15H,16-17H2,1-4H3,(H,31,32,36) UEDVVEREQMWTIV-UHFFFAOYSA-N 271597 US10065941, Compound I-098::US9732060, Compound I-098 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271597 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271597&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752322 378153425 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513625 CO[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ncccc3F)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(=O)OC 271598 US10065941, Compound I-099::US9732060, Compound I-099 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271598 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271598&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752304 378153426 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513626 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(Cl)cn3)cc2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 271599 US10065941, Compound I-100::US9732060, Compound I-100 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271599 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271599&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752313 378153427 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513627 Cc1ccc(Cn2c(=O)n(CC(C)(C)C(O)=O)c(=O)[nH]\c2=N/c2ccc(Oc3ccc(Cl)cn3)cc2)cc1 InChI=1S/C27H26ClN5O5/c1-17-4-6-18(7-5-17)15-32-24(31-25(36)33(26(32)37)16-27(2,3)23(34)35)30-20-9-11-21(12-10-20)38-22-13-8-19(28)14-29-22/h4-14H,15-16H2,1-3H3,(H,34,35)(H,30,31,36) DXWIIEZOAVIQDF-UHFFFAOYSA-N 271600 US10065941, Compound I-101::US9732060, Compound I-101 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271600 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271600&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752108 378153428 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513628 CO[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ncccc3F)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271601 US10065941, Compound I-102::US9732060, Compound I-102 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271601 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271601&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752105 378153429 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513629 COC(=O)[C@H](C)[C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(F)cn3)cc2)n(Cc2ccc(C)cc2)c1=O 271602 US10065941, Compound I-103::US9732060, Compound I-103 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271602 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271602&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752103 378153430 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513630 COC(=O)[C@H](C)[C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(F)n3)cc2)n(Cc2ccc(C)cc2)c1=O 271603 US10065941, Compound I-104::US9732060, Compound I-104 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271603 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271603&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752106 378153431 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513631 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(F)cn3)cc2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 271604 US10065941, Compound I-105::US9732060, Compound I-105 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271604 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271604&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752104 378153432 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513632 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(F)n3)cc2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 271605 US10065941, Compound I-106::US9732060, Compound I-106 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271605 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271605&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752186 378153433 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513633 COC(=O)[C@H](C)[C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3cc(C)ccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O 271606 US10065941, Compound I-107::US9732060, Compound I-107 P2X purinoceptor 3 Homo sapiens 31.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271606 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271606&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752165 378153434 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513634 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(C)cn3)cc2)n(Cc2ccc(C)cc2)c1=O 271607 US10065941, Compound I-108::US9732060, Compound I-108 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271607 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271607&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752162 378153435 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513635 COC(=O)[C@H](C)[C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(C)cn3)cc2)n(Cc2ccc(C)cc2)c1=O 271608 US10065941, Compound I-109::US9732060, Compound I-109 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271608 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271608&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752195 378153436 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513636 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(C)cn3)cc2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C29H31N5O5/c1-19-6-9-21(10-7-19)17-33-26(32-27(36)34(28(33)37)18-29(3,4)25(35)38-5)31-22-11-13-23(14-12-22)39-24-15-8-20(2)16-30-24/h6-16H,17-18H2,1-5H3,(H,31,32,36) PWWKPOCHRQULHN-UHFFFAOYSA-N 271609 US10065941, Compound I-110::US9732060, Compound I-110 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271609 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271609&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 86567076 378153437 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513637 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3cc(C)ccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271610 US10065941, Compound I-111::US9732060, Compound I-111 P2X purinoceptor 3 Homo sapiens 9.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271610 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271610&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752264 378153438 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513638 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(C)cn3)cc2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 271611 US10065941, Compound I-112::US9732060, Compound I-112 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271611 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271611&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752279 378153439 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513639 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(C)cn3)cc2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 271612 US10065941, Compound I-113::US9732060, Compound I-113 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271612 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271612&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752273 378153440 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513640 Cc1ccc(Cn2c(=O)n(CC(C)(C)C(O)=O)c(=O)[nH]\c2=N/c2ccc(Oc3ccc(C)cn3)cc2)cc1 InChI=1S/C28H29N5O5/c1-18-5-8-20(9-6-18)16-32-25(31-26(36)33(27(32)37)17-28(3,4)24(34)35)30-21-10-12-22(13-11-21)38-23-14-7-19(2)15-29-23/h5-15H,16-17H2,1-4H3,(H,34,35)(H,30,31,36) PCHZTGCPGFSPKI-UHFFFAOYSA-N 271613 US10065941, Compound I-114::US9732060, Compound I-114 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271613 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271613&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752289 378153441 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513641 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(Cl)n3)cc2)n(Cc2ccc(C)cc2)c1=O 271614 US10065941, Compound I-115::US9732060, Compound I-115 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271614 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271614&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752268 378153442 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513642 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(Cl)n3)cc2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C28H28ClN5O5/c1-18-8-10-19(11-9-18)16-33-25(32-26(36)34(27(33)37)17-28(2,3)24(35)38-4)30-20-12-14-21(15-13-20)39-23-7-5-6-22(29)31-23/h5-15H,16-17H2,1-4H3,(H,30,32,36) PLEHORDHPPBENR-UHFFFAOYSA-N 271615 US10065941, Compound I-116::US9732060, Compound I-116 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271615 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271615&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752188 378153443 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513643 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ncccc3Cl)cc2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 271616 US10065941, Compound I-117::US9732060, Compound I-117 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271616 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271616&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752220 378153444 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513644 Cc1ccc(Cn2c(=O)n(CC(C)(C)C(O)=O)c(=O)[nH]\c2=N/c2ccc(Oc3ncccc3Cl)cc2)cc1 InChI=1S/C27H26ClN5O5/c1-17-6-8-18(9-7-17)15-32-24(31-25(36)33(26(32)37)16-27(2,3)23(34)35)30-19-10-12-20(13-11-19)38-22-21(28)5-4-14-29-22/h4-14H,15-16H2,1-3H3,(H,34,35)(H,30,31,36) RDLRCBJETFQDKP-UHFFFAOYSA-N 271617 US10065941, Compound I-118::US9732060, Compound I-118 P2X purinoceptor 3 Homo sapiens 9.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271617 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271617&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752197 378153445 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513645 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(Cl)n3)cc2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 271618 US10065941, Compound I-119::US9732060, Compound I-119 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271618 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271618&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752169 378153446 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513646 COC(=O)[C@H](C)[C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(Cl)cn3)cc2)n(Cc2ccc(C)cc2)c1=O 271619 US10065941, Compound I-120::US9732060, Compound I-120 P2X purinoceptor 3 Homo sapiens 9.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271619 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271619&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752221 378153447 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513647 CO[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(F)cn3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(=O)OC 271620 US10065941, Compound I-121::US9732060, Compound I-121 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271620 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271620&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752306 378153448 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513648 CO[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(F)n3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(=O)OC 271621 US10065941, Compound I-122::US9732060, Compound I-122 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271621 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271621&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752325 378153449 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513649 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(Cl)cn3)cc2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 271622 US10065941, Compound I-123::US9732060, Compound I-123 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271622 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271622&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752307 378153450 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513650 CO[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(F)cn3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271623 US10065941, Compound I-124::US9732060, Compound I-124 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271623 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271623&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752314 378153451 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513651 CO[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(F)n3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271624 US10065941, Compound I-125::US9732060, Compound I-125 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271624 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271624&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752317 378153452 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513652 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O 271625 US10065941, Compound I-126::US9732060, Compound I-126 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271625 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271625&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 86567146 378153453 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513653 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271626 US10065941, Compound I-127::US9732060, Compound I-127 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271626 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271626&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752163 378153454 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513654 Cc1ccc(Cn2c(=O)n(CC(C)(C)C(O)=O)c(=O)[nH]\c2=N/c2ccc(Oc3cccc(Cl)n3)cc2)cc1 InChI=1S/C27H26ClN5O5/c1-17-7-9-18(10-8-17)15-32-24(31-25(36)33(26(32)37)16-27(2,3)23(34)35)29-19-11-13-20(14-12-19)38-22-6-4-5-21(28)30-22/h4-14H,15-16H2,1-3H3,(H,34,35)(H,29,31,36) QGLVKRQTERXNSW-UHFFFAOYSA-N 271627 US10065941, Compound I-128::US9732060, Compound I-128 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271627 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271627&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752303 378153455 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513655 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(F)cn3)cc2)n(Cc2ccc(C)cc2)c1=O 271535 US10065941, Compound I-036::US10065941, Compound I-129::US9732060, Compound I-129 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271535 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271535&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752331 378153363 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513656 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(F)cn3)cc2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 271539 US10065941, Compound I-040::US10065941, Compound I-130::US9732060, Compound I-130 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271539 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271539&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752335 378153367 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513657 COC(=O)[C@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O 271630 US10065941, Compound I-131::US9732060, Compound I-131 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271630 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271630&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752349 378153456 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513658 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(OC(F)F)cn3)cc2)n(Cc2ccc(C)cc2)c1=O 271631 US10065941, Compound I-132::US9732060, Compound I-132 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271631 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271631&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752350 378153457 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513659 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(OC(F)F)cn3)cc2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C29H29F2N5O6/c1-18-5-7-19(8-6-18)16-35-26(34-27(38)36(28(35)39)17-29(2,3)24(37)40-4)33-20-9-11-21(12-10-20)41-23-14-13-22(15-32-23)42-25(30)31/h5-15,25H,16-17H2,1-4H3,(H,33,34,38) LBJZGZMIIBOMIG-UHFFFAOYSA-N 271632 US10065941, Compound I-133::US9732060, Compound I-133 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271632 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271632&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752352 378153458 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513660 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3cc(ccn3)C#N)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271633 US10065941, Compound I-134::US9732060, Compound I-134 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271633 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271633&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752353 378153459 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513661 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(OC(F)F)cn3)cc2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 271634 US10065941, Compound I-135::US9732060, Compound I-135 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271634 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271634&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752351 378153460 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513662 Cc1ccc(Cn2c(=O)n(CC(C)(C)C(O)=O)c(=O)[nH]\c2=N/c2ccc(Oc3ccc(OC(F)F)cn3)cc2)cc1 InChI=1S/C28H27F2N5O6/c1-17-4-6-18(7-5-17)15-34-25(33-26(38)35(27(34)39)16-28(2,3)23(36)37)32-19-8-10-20(11-9-19)40-22-13-12-21(14-31-22)41-24(29)30/h4-14,24H,15-16H2,1-3H3,(H,36,37)(H,32,33,38) YSHQUEFTCQOIOI-UHFFFAOYSA-N 271635 US10065941, Compound I-136::US9732060, Compound I-136 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271635 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271635&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752291 378153461 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513663 COC(=O)[C@H](C)[C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(OC(F)F)cn3)cc2)n(Cc2ccc(C)cc2)c1=O 271636 US10065941, Compound I-137::US9732060, Compound I-137 P2X purinoceptor 3 Homo sapiens 14.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271636 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271636&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752271 378153462 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513664 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(OC(F)F)cn3)cc2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 271637 US10065941, Compound I-138::US10065941, Compound R-216::US9732060, Compound R-216 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271637 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271637&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752285 378153463 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513665 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cc(OC)ccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O 271638 US10065941, Compound I-139::US9732060, Compound I-139 P2X purinoceptor 3 Homo sapiens 10.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271638 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271638&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752272 378153464 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513666 COC(=O)[C@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(Cc2ccc(C)cc2)c1=O 271639 US10065941, Compound I-140::US9732060, Compound I-140 P2X purinoceptor 3 Homo sapiens 3.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271639 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271639&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752161 378153465 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513667 C[C@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271640 US10065941, Compound I-141::US9732060, Compound I-141 P2X purinoceptor 3 Homo sapiens 14.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271640 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271640&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 86567144 378153466 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513668 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(C[C@H]2CC[C@H](C)CC2)c1=O 271641 US10065941, Compound I-142 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271641 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271641&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 132245062 378153467 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513669 CO[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(=O)OC 271642 US10065941, Compound I-143::US9732060, Compound I-143 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271642 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271642&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752348 378153468 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513670 COC(=O)[C@H](C)[C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O 271643 US10065941, Compound I-144::US9732060, Compound I-144 P2X purinoceptor 3 Homo sapiens 9.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271643 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271643&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295425 378153469 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513671 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(C[C@H]2CC[C@H](C)CC2)c1=O)C(O)=O 271644 US10065941, Compound I-145 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271644 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271644&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752345 378153470 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513672 CO[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271645 US10065941, Compound I-146::US9732060, Compound I-146 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271645 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271645&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295426 378153471 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513673 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271646 US10065941, Compound I-147::US9732060, Compound I-147 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271646 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271646&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752230 378153472 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513674 C[C@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 271647 US10065941, Compound I-148::US9732060, Compound I-148 P2X purinoceptor 3 Homo sapiens 9.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271647 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271647&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752200 378153473 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513675 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C27H26ClN5O5/c1-27(2,23(34)37-3)17-33-25(35)31-24(32(26(33)36)16-18-7-9-19(28)10-8-18)30-20-11-13-21(14-12-20)38-22-6-4-5-15-29-22/h4-15H,16-17H2,1-3H3,(H,30,31,35) RBEFUDKJTIITFD-UHFFFAOYSA-N 271648 US10065941, Compound I-149::US9732060, Compound I-149 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271648 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271648&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752223 378153474 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513676 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C28H29N5O5/c1-19-8-10-20(11-9-19)17-32-25(31-26(35)33(27(32)36)18-28(2,3)24(34)37-4)30-21-12-14-22(15-13-21)38-23-7-5-6-16-29-23/h5-16H,17-18H2,1-4H3,(H,30,31,35) GGWDQLSVRFVYNF-UHFFFAOYSA-N 271649 US10065941, Compound I-150::US9732060, Compound I-150 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271649 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271649&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 86567204 378153475 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513677 COC(=O)[C@@H](C)[C@@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O 271650 US10065941, Compound I-151::US9732060, Compound I-151 P2X purinoceptor 3 Homo sapiens 10.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271650 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271650&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752269 378153476 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513678 CC(C)(C)n1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(cn3)-c3cccc(c3)C(O)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C32H28ClN5O5/c1-32(2,3)38-30(41)36-29(37(31(38)42)19-20-7-10-24(33)11-8-20)35-25-12-14-26(15-13-25)43-27-16-9-23(18-34-27)21-5-4-6-22(17-21)28(39)40/h4-18H,19H2,1-3H3,(H,39,40)(H,35,36,41) MVOFXOLVQPEOON-UHFFFAOYSA-N 271651 US10065941, Compound R-001::US9732060, Compound R-001 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271651 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271651&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295463 378153477 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513679 C[C@@H]([C@@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271652 US10065941, Compound I-152::US9732060, Compound I-152 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271652 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271652&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752270 378153478 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513680 COC(=O)c1cccc(c1)-c1ccc(Oc2ccc(cc2)\N=c2/[nH]c(=O)[nH]c(=O)n2Cc2ccc(Cl)cc2)nc1 InChI=1S/C29H22ClN5O5/c1-39-26(36)20-4-2-3-19(15-20)21-7-14-25(31-16-21)40-24-12-10-23(11-13-24)32-27-33-28(37)34-29(38)35(27)17-18-5-8-22(30)9-6-18/h2-16H,17H2,1H3,(H2,32,33,34,37,38) ODKZZHFIDIJWOL-UHFFFAOYSA-N 271653 US10065941, Compound R-002::US9732060, Compound R-002 P2X purinoceptor 3 Homo sapiens 363 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271653 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271653&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295464 378153479 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513681 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ncccc3OC)cc2)n(Cc2ccc(Cl)cc2)c1=O 271654 US10065941, Compound I-153::US9732060, Compound I-153 P2X purinoceptor 3 Homo sapiens 13.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271654 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271654&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752290 378153480 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513682 OC(=O)c1cccc(c1)-c1ccc(Oc2ccc(cc2)\N=c2/[nH]c(=O)[nH]c(=O)n2Cc2ccc(Cl)cc2)nc1 InChI=1S/C28H20ClN5O5/c29-21-7-4-17(5-8-21)16-34-26(32-27(37)33-28(34)38)31-22-9-11-23(12-10-22)39-24-13-6-20(15-30-24)18-2-1-3-19(14-18)25(35)36/h1-15H,16H2,(H,35,36)(H2,31,32,33,37,38) FTUIUPQPRKNGCJ-UHFFFAOYSA-N 271655 US10065941, Compound R-003::US9732060, Compound R-003 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271655 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271655&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295465 378153481 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513683 CC(C)(Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O InChI=1S/C26H24ClN5O5/c1-26(2,22(33)34)16-32-24(35)30-23(31(25(32)36)15-17-6-8-18(27)9-7-17)29-19-10-12-20(13-11-19)37-21-5-3-4-14-28-21/h3-14H,15-16H2,1-2H3,(H,33,34)(H,29,30,35) QXIYPDRPHDQUBK-UHFFFAOYSA-N 271656 US10065941, Compound I-154::US9732060, Compound I-154 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271656 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271656&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752266 378153482 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513684 COC(=O)c1ccc(NC(=O)c2cccc(Oc3ccc(cc3)\N=c3/[nH]c(=O)n(C)c(=O)n3C[C@H]3CC[C@H](C)CC3)n2)cc1 271657 US10065941, Compound R-004::US9732060, Compound R-004 P2X purinoceptor 3 Homo sapiens 123 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271657 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271657&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752363 378153483 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513685 Cc1ccc(Cn2c(=O)n(CC(C)(C)C(O)=O)c(=O)[nH]\c2=N/c2ccc(Oc3ccccn3)cc2)cc1 InChI=1S/C27H27N5O5/c1-18-7-9-19(10-8-18)16-31-24(30-25(35)32(26(31)36)17-27(2,3)23(33)34)29-20-11-13-21(14-12-20)37-22-6-4-5-15-28-22/h4-15H,16-17H2,1-3H3,(H,33,34)(H,29,30,35) XJQRYNDTFVPSJC-UHFFFAOYSA-N 271658 US10065941, Compound I-155::US9732060, Compound I-155 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271658 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271658&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752267 378153484 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513686 CCn1c(=O)[nH]\c(=N/c2ccc(cc2)-c2ccc(cn2)C#N)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H19ClN6O2/c1-2-30-23(32)29-22(31(24(30)33)15-16-3-8-19(25)9-4-16)28-20-10-6-18(7-11-20)21-12-5-17(13-26)14-27-21/h3-12,14H,2,15H2,1H3,(H,28,29,32) PLQUOVWNAAKCCC-UHFFFAOYSA-N 271659 US10065941, Compound R-005::US9732060, Compound R-005 P2X purinoceptor 3 Homo sapiens 608 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271659 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271659&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295466 378153485 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513687 COc1cccnc1Oc1ccc(cc1)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 271660 US10065941, Compound I-156::US9732060, Compound I-156 P2X purinoceptor 3 Homo sapiens 12.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271660 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271660&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752095 378153486 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513688 C[C@H]1CC[C@H](Cn2c(=O)n(C)c(=O)[nH]\c2=N/c2ccc(Oc3cccc(n3)C(=O)Nc3ccc(cc3)C(O)=O)cc2)CC1 271661 US10065941, Compound R-006 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271661 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271661&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752376 378153487 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513689 COC(=O)C[C@@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O 271662 US10065941, Compound I-157::US9732060, Compound I-157 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271662 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271662&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752100 378153488 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513690 CCn1c(=O)nc(Nc2ccc3nc(oc3c2)C(C)C)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C22H22ClN5O3/c1-4-27-21(29)26-20(28(22(27)30)12-14-5-7-15(23)8-6-14)24-16-9-10-17-18(11-16)31-19(25-17)13(2)3/h5-11,13H,4,12H2,1-3H3,(H,24,26,29) VBMLVOYQNOZDNL-UHFFFAOYSA-N 271663 US10065941, Compound R-007::US9732060, Compound R-007 P2X purinoceptor 3 Homo sapiens 301 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271663 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271663&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 136213973 378153489 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513691 COC(=O)C[C@@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(F)n3)cc2)n(Cc2ccc(Cl)cc2)c1=O 271664 US10065941, Compound I-158::US9732060, Compound I-158 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271664 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271664&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295427 378153490 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513692 COc1cc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n([C@@H](C)[C@@H](C)C(O)=O)c(=O)n2Cc2ccc(Cl)cc2)ccn1 271665 US10065941, Compound R-009::US9732060, Compound R-009 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271665 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271665&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295469 378153491 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513693 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ncccc3OC)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C28H28ClN5O6/c1-28(2,24(35)39-4)17-34-26(36)32-25(33(27(34)37)16-18-7-9-19(29)10-8-18)31-20-11-13-21(14-12-20)40-23-22(38-3)6-5-15-30-23/h5-15H,16-17H2,1-4H3,(H,31,32,36) WFQKGDPSJURZMD-UHFFFAOYSA-N 271666 US10065941, Compound I-159::US9732060, Compound I-159 P2X purinoceptor 3 Homo sapiens 9.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271666 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271666&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752101 378153492 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513694 COc1nccc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n([C@@H](C)[C@@H](C)C(O)=O)c(=O)n2Cc2ccc(Cl)cc2)n1 271667 US10065941, Compound R-010::US9732060, Compound R-010 P2X purinoceptor 3 Homo sapiens 10.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271667 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271667&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295470 378153493 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513695 COC(=O)C[C@@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(F)cn3)cc2)n(Cc2ccc(Cl)cc2)c1=O 271668 US10065941, Compound I-160::US9732060, Compound I-160 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271668 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271668&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295428 378153494 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513696 CC(C)n1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(n3)C#N)c(Cl)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H20Cl2N6O3/c1-15(2)33-24(34)31-23(32(25(33)35)14-16-6-8-17(26)9-7-16)30-18-10-11-21(20(27)12-18)36-22-5-3-4-19(13-28)29-22/h3-12,15H,14H2,1-2H3,(H,30,31,34) RRJYLKBBXADXIX-UHFFFAOYSA-N 271669 US10065941, Compound R-011::US9732060, Compound R-011 P2X purinoceptor 3 Homo sapiens 49.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271669 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271669&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295471 378153495 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513697 COC(=O)C[C@@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3ncccc3F)cc2)n(Cc2ccc(Cl)cc2)c1=O 271670 US10065941, Compound I-161::US9732060, Compound I-161 P2X purinoceptor 3 Homo sapiens 10.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271670 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271670&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752180 378153496 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513698 CC(C)n1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(n3)C(O)=O)c(Cl)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H21Cl2N5O5/c1-14(2)32-24(35)30-23(31(25(32)36)13-15-6-8-16(26)9-7-15)28-17-10-11-20(18(27)12-17)37-21-5-3-4-19(29-21)22(33)34/h3-12,14H,13H2,1-2H3,(H,33,34)(H,28,30,35) QKWZGWJSVAKJEE-UHFFFAOYSA-N 271671 US10065941, Compound R-012::US9732060, Compound R-012 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271671 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271671&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295472 378153497 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513699 C[C@H](CC(O)=O)n1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O 271672 US10065941, Compound I-162::US9732060, Compound I-162 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271672 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271672&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752190 378153498 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513700 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cnc(Cl)cn3)cc2)n(Cc2ccc(Cl)cc2)c1=O 271673 US10065941, Compound R-013::US9732060, Compound R-013 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271673&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295473 378153499 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513701 C[C@H](CC(O)=O)n1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(F)n3)cc2)n(Cc2ccc(Cl)cc2)c1=O 271674 US10065941, Compound I-163::US9732060, Compound I-163 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271674 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271674&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752181 378153500 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513702 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cnc(Cl)cn3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271675 US10065941, Compound R-014::US9732060, Compound R-014 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271675 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271675&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295474 378153501 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513703 COc1cccnc1Oc1ccc(cc1)\N=c1/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C27H26ClN5O6/c1-27(2,23(34)35)16-33-25(36)31-24(32(26(33)37)15-17-6-8-18(28)9-7-17)30-19-10-12-20(13-11-19)39-22-21(38-3)5-4-14-29-22/h4-14H,15-16H2,1-3H3,(H,34,35)(H,30,31,36) OPZBTTMNFHGNRQ-UHFFFAOYSA-N 271676 US10065941, Compound I-164::US9732060, Compound I-164 P2X purinoceptor 3 Homo sapiens 29.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271676 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271676&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752198 378153502 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513704 CCOC(=O)c1cnc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(CC)c(=O)n2Cc2ccc(Cl)cc2)c(Cl)c1 InChI=1S/C26H23Cl2N5O5/c1-3-32-25(35)31-24(33(26(32)36)15-16-5-7-18(27)8-6-16)30-19-9-11-20(12-10-19)38-22-21(28)13-17(14-29-22)23(34)37-4-2/h5-14H,3-4,15H2,1-2H3,(H,30,31,35) WRUVNESKJUZMAL-UHFFFAOYSA-N 271677 US10065941, Compound R-015::US9732060, Compound R-015 P2X purinoceptor 3 Homo sapiens 104 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271677 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271677&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121280871 378153503 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513705 C[C@H](CC(O)=O)n1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(F)cn3)cc2)n(Cc2ccc(Cl)cc2)c1=O 271678 US10065941, Compound I-165::US9732060, Compound I-165 P2X purinoceptor 3 Homo sapiens 15.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271678 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271678&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295429 378153504 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513706 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ncc(cc3Cl)C(O)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H19Cl2N5O5/c1-2-30-23(34)29-22(31(24(30)35)13-14-3-5-16(25)6-4-14)28-17-7-9-18(10-8-17)36-20-19(26)11-15(12-27-20)21(32)33/h3-12H,2,13H2,1H3,(H,32,33)(H,28,29,34) APOGATSIIDPPRZ-UHFFFAOYSA-N 271679 US10065941, Compound R-016::US9732060, Compound R-016 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271679 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271679&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121280828 378153505 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513707 C[C@H](CC(O)=O)n1c(=O)[nH]\c(=N/c2ccc(Oc3ncccc3F)cc2)n(Cc2ccc(Cl)cc2)c1=O 271680 US10065941, Compound I-166::US9732060, Compound I-166 P2X purinoceptor 3 Homo sapiens 13.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271680 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271680&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752295 378153506 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513708 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cnccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O 271681 US10065941, Compound R-017::US9732060, Compound R-017 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271681 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271681&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295475 378153507 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513709 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(F)cn3)cc2)n(Cc2ccc(cc2)C(F)F)c1=O)C(O)=O 271682 US10065941, Compound I-167::US9732060, Compound I-167 P2X purinoceptor 3 Homo sapiens 19.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271682 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271682&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752278 378153508 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513710 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cnccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H25ClN6O5/c1-26(2,22(34)37-3)16-33-24(35)31-23(32(25(33)36)15-17-4-6-18(27)7-5-17)30-19-8-10-20(11-9-19)38-21-14-28-12-13-29-21/h4-14H,15-16H2,1-3H3,(H,30,31,35) UIIMWNKGAHFXQR-UHFFFAOYSA-N 271683 US10065941, Compound R-018::US9732060, Compound R-018 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271683 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271683&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295476 378153509 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513711 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(F)n3)cc2)n(Cc2ccc(cc2)C(F)F)c1=O)C(O)=O 271684 US10065941, Compound I-168::US9732060, Compound I-168 P2X purinoceptor 3 Homo sapiens 12.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271684 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271684&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752275 378153510 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513712 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cnccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271685 US10065941, Compound R-019::US9732060, Compound R-019 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271685 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271685&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295477 378153511 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513713 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ncccc3F)cc2)n(Cc2ccc(cc2)C(F)F)c1=O)C(O)=O 271686 US10065941, Compound I-169::US9732060, Compound I-169 P2X purinoceptor 3 Homo sapiens 21.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271686 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271686&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752286 378153512 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513714 CC(C)(Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cnccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O InChI=1S/C25H23ClN6O5/c1-25(2,21(33)34)15-32-23(35)30-22(31(24(32)36)14-16-3-5-17(26)6-4-16)29-18-7-9-19(10-8-18)37-20-13-27-11-12-28-20/h3-13H,14-15H2,1-2H3,(H,33,34)(H,29,30,35) DVJQMYXLYGAUNZ-UHFFFAOYSA-N 271687 US10065941, Compound R-020::US9732060, Compound R-020 P2X purinoceptor 3 Homo sapiens 13.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271687 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271687&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295478 378153513 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513715 CCOC(=O)[C@H]1C[C@@H](C1)n1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O 271688 US10065941, Compound I-170::US9732060, Compound I-170 P2X purinoceptor 3 Homo sapiens 15.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271688 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271688&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295430 378153514 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513716 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n([C@H]2C[C@@H](C2)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 271689 US10065941, Compound R-021::US9732060, Compound R-021 P2X purinoceptor 3 Homo sapiens 15.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271689 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271689&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295479 378153515 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513717 CCOC(=O)[C@H]1C[C@H](C1)n1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O 271690 US10065941, Compound I-171::US9732060, Compound I-171 P2X purinoceptor 3 Homo sapiens 9.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271690 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271690&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295430 378153516 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513718 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n([C@@H]2C[C@@H](C2)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 271691 US10065941, Compound R-022::US9732060, Compound R-022 P2X purinoceptor 3 Homo sapiens 12.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271691 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271691&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295479 378153517 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513719 CCOC(=O)[C@H]1C[C@@H](C1)n1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(Cl)cn3)cc2)n(Cc2ccc(C)cc2)c1=O 271692 US10065941, Compound I-172::US9732060, Compound I-172 P2X purinoceptor 3 Homo sapiens 26.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271692 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271692&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752084 378153518 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513720 CCc1oc2ccc(cc2c1C)\N=c1/[nH]c(=O)n([C@H]2C[C@@H](C2)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 271693 US10065941, Compound R-023::US9732060, Compound R-023 P2X purinoceptor 3 Homo sapiens 21.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271693 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271693&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295480 378153519 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513721 CCOC(=O)[C@H]1C[C@H](C1)n1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(Cl)cn3)cc2)n(Cc2ccc(C)cc2)c1=O 271694 US10065941, Compound I-173::US9732060, Compound I-173 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271694 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271694&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752084 378153520 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513722 CCc1oc2ccc(cc2c1C)\N=c1/[nH]c(=O)n([C@@H]2C[C@@H](C2)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 271695 US10065941, Compound R-024::US9732060, Compound R-024 P2X purinoceptor 3 Homo sapiens 18.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271695 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271695&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295480 378153521 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513723 OC(=O)[C@H]1C[C@@H](C1)n1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O 271696 US10065941, Compound I-174::US9732060, Compound I-174 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271696 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271696&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752081 378153522 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513724 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cnc(Cl)cn3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H24Cl2N6O5/c1-26(2,22(35)38-3)15-34-24(36)32-23(33(25(34)37)14-16-4-6-17(27)7-5-16)31-18-8-10-19(11-9-18)39-21-13-29-20(28)12-30-21/h4-13H,14-15H2,1-3H3,(H,31,32,36) CYARJWMGFCOFND-UHFFFAOYSA-N 271697 US10065941, Compound R-025::US9732060, Compound R-025 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271697 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271697&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295481 378153523 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513725 OC(=O)[C@H]1C[C@H](C1)n1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O 271698 US10065941, Compound I-175::US9732060, Compound I-175 P2X purinoceptor 3 Homo sapiens 9.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271698 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271698&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752081 378153524 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513726 COC(=O)C(C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(OC(F)F)cn3)cc2)n(Cc2ccc(Cl)cc2)c1=O 271699 US10065941, Compound R-026::US9732060, Compound R-026 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271699 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271699&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295484 378153525 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513727 CCOC(=O)[C@H]1C[C@@H](C1)n1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(F)cn3)cc2)n(Cc2ccc(C)cc2)c1=O 271700 US10065941, Compound I-176::US9732060, Compound I-176 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271700 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271700&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752212 378153526 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513728 CC(C)(Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cnc(Cl)cn3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O InChI=1S/C25H22Cl2N6O5/c1-25(2,21(34)35)14-33-23(36)31-22(32(24(33)37)13-15-3-5-16(26)6-4-15)30-17-7-9-18(10-8-17)38-20-12-28-19(27)11-29-20/h3-12H,13-14H2,1-2H3,(H,34,35)(H,30,31,36) AYWPYOKNYIKNFU-UHFFFAOYSA-N 271701 US10065941, Compound R-027::US9732060, Compound R-027 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271701 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271701&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295483 378153527 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513729 CCOC(=O)[C@H]1C[C@H](C1)n1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(F)cn3)cc2)n(Cc2ccc(C)cc2)c1=O 271702 US10065941, Compound I-177::US9732060, Compound I-177 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271702 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271702&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752212 378153528 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513730 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(nn3)C(F)(F)F)cc2)n(Cc2ccc(Cl)cc2)c1=O 271703 US10065941, Compound R-028::US9732060, Compound R-028 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271703 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271703&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295482 378153529 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513731 Cc1ccc(Cn2c(=O)n([C@H]3C[C@@H](C3)C(O)=O)c(=O)[nH]\c2=N/c2ccc(Oc3ccc(Cl)cn3)cc2)cc1 271704 US10065941, Compound I-178::US9732060, Compound I-178 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271704 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271704&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295392 378153530 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513732 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(nn3)C(F)(F)F)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C27H24ClF3N6O5/c1-26(2,22(38)41-3)15-37-24(39)33-23(36(25(37)40)14-16-4-6-17(28)7-5-16)32-18-8-10-19(11-9-18)42-21-13-12-20(34-35-21)27(29,30)31/h4-13H,14-15H2,1-3H3,(H,32,33,39) HFWYOVIAPYRHST-UHFFFAOYSA-N 271705 US10065941, Compound R-029::US9732060, Compound R-029 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271705 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271705&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295485 378153531 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513733 Cc1ccc(Cn2c(=O)n([C@@H]3C[C@@H](C3)C(O)=O)c(=O)[nH]\c2=N/c2ccc(Oc3ccc(Cl)cn3)cc2)cc1 271706 US10065941, Compound I-179::US9732060, Compound I-179 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271706 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271706&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295392 378153532 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513734 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(nn3)C(F)(F)F)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271707 US10065941, Compound R-030::US9732060, Compound R-030 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271707 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271707&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295486 378153533 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513735 CCOC(=O)[C@H]1C[C@@H](C1)n1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(Cc2ccc(C)cc2)c1=O 271708 US10065941, Compound I-180 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271708 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271708&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752206 378153534 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513736 CC(C)(Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(nn3)C(F)(F)F)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O InChI=1S/C26H22ClF3N6O5/c1-25(2,21(37)38)14-36-23(39)32-22(35(24(36)40)13-15-3-5-16(27)6-4-15)31-17-7-9-18(10-8-17)41-20-12-11-19(33-34-20)26(28,29)30/h3-12H,13-14H2,1-2H3,(H,37,38)(H,31,32,39) UDUPYIQZPNAMKN-UHFFFAOYSA-N 271709 US10065941, Compound R-031::US9732060, Compound R-031 P2X purinoceptor 3 Homo sapiens 12.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271709 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271709&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295487 378153535 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513737 CCOC(=O)[C@H]1C[C@H](C1)n1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(Cc2ccc(C)cc2)c1=O 271710 US10065941, Compound I-181::US9732060, Compound I-181 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271710 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271710&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752206 378153536 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513738 COc1cc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n2Cc2ccc(Cl)cc2)ccn1 271711 US10065941, Compound R-032::US9732060, Compound R-032 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271711 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271711&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295489 378153537 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513739 Cc1ccc(Cn2c(=O)n([C@H]3C[C@@H](C3)C(O)=O)c(=O)[nH]\c2=N/c2ccc(Oc3ccc(F)cn3)cc2)cc1 271712 US10065941, Compound I-182::US9732060, Compound I-182 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271712 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271712&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752224 378153538 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513740 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cccnn3)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O 271713 US10065941, Compound R-033::US9732060, Compound R-033 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271713 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271713&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295488 378153539 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513741 Cc1ccc(Cn2c(=O)n([C@@H]3C[C@@H](C3)C(O)=O)c(=O)[nH]\c2=N/c2ccc(Oc3ccc(F)cn3)cc2)cc1 271714 US10065941, Compound I-183::US9732060, Compound I-183 P2X purinoceptor 3 Homo sapiens 12.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271714 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271714&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752224 378153540 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513742 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cccnn3)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H24ClFN6O5/c1-26(2,22(35)38-3)15-34-24(36)31-23(33(25(34)37)14-16-6-8-17(27)9-7-16)30-18-10-11-20(19(28)13-18)39-21-5-4-12-29-32-21/h4-13H,14-15H2,1-3H3,(H,30,31,36) ZCNBNHGEJQGTCD-UHFFFAOYSA-N 271715 US10065941, Compound R-034::US9732060, Compound R-034 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271715 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271715&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295491 378153541 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513743 Cc1ccc(Cn2c(=O)n([C@H]3C[C@@H](C3)C(O)=O)c(=O)[nH]\c2=N/c2ccc(Oc3ccccn3)cc2)cc1 271716 US10065941, Compound I-184::US9732060, Compound I-184 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271716 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271716&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752205 378153542 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513744 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cnc(cn3)C(F)(F)F)cc2)n(Cc2ccc(Cl)cc2)c1=O 271717 US10065941, Compound R-035::US9732060, Compound R-035 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271717 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271717&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295490 378153543 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513745 Cc1ccc(Cn2c(=O)n([C@@H]3C[C@@H](C3)C(O)=O)c(=O)[nH]\c2=N/c2ccc(Oc3ccccn3)cc2)cc1 271718 US10065941, Compound I-185::US9732060, Compound I-185 P2X purinoceptor 3 Homo sapiens 9.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271718 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271718&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752205 378153544 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513746 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cnc(cn3)C(F)(F)F)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C27H24ClF3N6O5/c1-26(2,22(38)41-3)15-37-24(39)35-23(36(25(37)40)14-16-4-6-17(28)7-5-16)34-18-8-10-19(11-9-18)42-21-13-32-20(12-33-21)27(29,30)31/h4-13H,14-15H2,1-3H3,(H,34,35,39) ICJNQKKAAKFFRD-UHFFFAOYSA-N 271719 US10065941, Compound R-036::US9732060, Compound R-036 P2X purinoceptor 3 Homo sapiens 11.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271719 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271719&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295492 378153545 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513747 COC(=O)C[C@@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(Cc2ccc(C)cc2)c1=O 271720 US10065941, Compound I-186::US9732060, Compound I-186 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271720 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271720&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752191 378153546 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513748 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cccnn3)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271721 US10065941, Compound R-037::US9732060, Compound R-037 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271721 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271721&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295494 378153547 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513749 C[C@H](CC(O)=O)n1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(Cc2ccc(C)cc2)c1=O 271722 US10065941, Compound I-187::US9732060, Compound I-187 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271722 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271722&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752182 378153548 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513750 CC(C)(Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cccnn3)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O InChI=1S/C25H22ClFN6O5/c1-25(2,21(34)35)14-33-23(36)30-22(32(24(33)37)13-15-5-7-16(26)8-6-15)29-17-9-10-19(18(27)12-17)38-20-4-3-11-28-31-20/h3-12H,13-14H2,1-2H3,(H,34,35)(H,29,30,36) BLIMNJQAPWJVRX-UHFFFAOYSA-N 271723 US10065941, Compound R-038::US9732060, Compound R-038 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271723 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271723&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295493 378153549 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513751 COC(=O)C[C@@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3ncccc3F)cc2)n(Cc2ccc(C)cc2)c1=O 271724 US10065941, Compound I-188 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271724 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271724&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752171 378153550 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513752 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cnc(cn3)C(F)(F)F)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271725 US10065941, Compound R-039::US9732060, Compound R-039 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271725 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271725&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295495 378153551 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513753 C[C@H](CC(O)=O)n1c(=O)[nH]\c(=N/c2ccc(Oc3ncccc3F)cc2)n(Cc2ccc(C)cc2)c1=O 271726 US10065941, Compound I-189::US9732060, Compound I-189 P2X purinoceptor 3 Homo sapiens 12.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271726 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271726&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752172 378153552 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513754 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cc(F)nc(F)c3)cc2)n(Cc2ccc(Cl)cc2)c1=O 271727 US10065941, Compound R-040::US9732060, Compound R-040 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271727 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271727&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295496 378153553 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513755 COC(=O)C[C@@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(F)cn3)cc2)n(Cc2ccc(C)cc2)c1=O 271728 US10065941, Compound I-190 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271728 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271728&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752183 378153554 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513756 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cc(F)nc(F)c3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C27H24ClF2N5O5/c1-27(2,23(36)39-3)15-35-25(37)33-24(34(26(35)38)14-16-4-6-17(28)7-5-16)31-18-8-10-19(11-9-18)40-20-12-21(29)32-22(30)13-20/h4-13H,14-15H2,1-3H3,(H,31,33,37) KVDCRNHHUBBWBR-UHFFFAOYSA-N 271729 US10065941, Compound R-041::US9732060, Compound R-041 P2X purinoceptor 3 Homo sapiens 11.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271729 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271729&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295497 378153555 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513757 C[C@H](CC(O)=O)n1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(F)cn3)cc2)n(Cc2ccc(C)cc2)c1=O 271730 US10065941, Compound I-191::US9732060, Compound I-191 P2X purinoceptor 3 Homo sapiens 11.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271730 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271730&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752114 378153556 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513758 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccnc(C)n3)cc2)n(Cc2ccc(Cl)cc2)c1=O 271731 US10065941, Compound R-042::US9732060, Compound R-042 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271731 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271731&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295498 378153557 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513759 CCOC(=O)C1(Cn2c(=O)[nH]\c(=N/c3ccc(Oc4ccccn4)cc3)n(Cc3ccc(Cl)cc3)c2=O)CC1 InChI=1S/C28H26ClN5O5/c1-2-38-24(35)28(14-15-28)18-34-26(36)32-25(33(27(34)37)17-19-6-8-20(29)9-7-19)31-21-10-12-22(13-11-21)39-23-5-3-4-16-30-23/h3-13,16H,2,14-15,17-18H2,1H3,(H,31,32,36) YVTVATISFXSKSO-UHFFFAOYSA-N 271732 US10065941, Compound I-192::US9732060, Compound I-192 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271732 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271732&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752110 378153558 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513760 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccnc(C)n3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C27H27ClN6O5/c1-17-29-14-13-22(30-17)39-21-11-9-20(10-12-21)31-24-32-25(36)34(16-27(2,3)23(35)38-4)26(37)33(24)15-18-5-7-19(28)8-6-18/h5-14H,15-16H2,1-4H3,(H,31,32,36) PDDLXXRDCRKPGS-UHFFFAOYSA-N 271733 US10065941, Compound R-043::US9732060, Compound R-043 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271733 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271733&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295499 378153559 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513761 OC(=O)C1(Cn2c(=O)[nH]\c(=N/c3ccc(Oc4ccccn4)cc3)n(Cc3ccc(Cl)cc3)c2=O)CC1 InChI=1S/C26H22ClN5O5/c27-18-6-4-17(5-7-18)15-31-23(30-24(35)32(25(31)36)16-26(12-13-26)22(33)34)29-19-8-10-20(11-9-19)37-21-3-1-2-14-28-21/h1-11,14H,12-13,15-16H2,(H,33,34)(H,29,30,35) LYCIFQWBCYVZSS-UHFFFAOYSA-N 271734 US10065941, Compound I-193::US9732060, Compound I-193 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271734 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271734&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752111 378153560 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513762 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccnc(C)n3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271735 US10065941, Compound R-044::US9732060, Compound R-044 P2X purinoceptor 3 Homo sapiens 10.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271735 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271735&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295500 378153561 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513763 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(Cc2ccc(cc2)C(F)F)c1=O 271736 US10065941, Compound I-194::US9732060, Compound I-194 P2X purinoceptor 3 Homo sapiens 12.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271736 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271736&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752112 378153562 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513764 Cc1nccc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n2Cc2ccc(Cl)cc2)n1 InChI=1S/C26H25ClN6O5/c1-16-28-13-12-21(29-16)38-20-10-8-19(9-11-20)30-23-31-24(36)33(15-26(2,3)22(34)35)25(37)32(23)14-17-4-6-18(27)7-5-17/h4-13H,14-15H2,1-3H3,(H,34,35)(H,30,31,36) ZAEYTCAZPLVGBC-UHFFFAOYSA-N 271737 US10065941, Compound R-045::US9732060, Compound R-045 P2X purinoceptor 3 Homo sapiens 14.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271737 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271737&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295501 378153563 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513765 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 271738 US10065941, Compound I-195::US9732060, Compound I-195 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271738 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271738&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752113 378153564 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513766 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cc(Cl)ncn3)cc2)n(Cc2ccc(Cl)cc2)c1=O 271739 US10065941, Compound R-046::US9732060, Compound R-046 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271739 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271739&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295502 378153565 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513767 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cc(Cl)ncn3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H24Cl2N6O5/c1-26(2,22(35)38-3)14-34-24(36)32-23(33(25(34)37)13-16-4-6-17(27)7-5-16)31-18-8-10-19(11-9-18)39-21-12-20(28)29-15-30-21/h4-12,15H,13-14H2,1-3H3,(H,31,32,36) JWUQBNMBSHZLHT-UHFFFAOYSA-N 271740 US10065941, Compound R-047::US9732060, Compound R-047 P2X purinoceptor 3 Homo sapiens 9.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271740 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271740&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295503 378153566 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513768 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cnccn3)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O 271741 US10065941, Compound R-048::US9732060, Compound R-048 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271741 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271741&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295504 378153567 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513769 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cnccn3)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H24ClFN6O5/c1-26(2,22(35)38-3)15-34-24(36)32-23(33(25(34)37)14-16-4-6-17(27)7-5-16)31-18-8-9-20(19(28)12-18)39-21-13-29-10-11-30-21/h4-13H,14-15H2,1-3H3,(H,31,32,36) ZBVNZASTUVAISF-UHFFFAOYSA-N 271742 US10065941, Compound R-049::US9732060, Compound R-049 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271742 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271742&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295505 378153568 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513770 COc1cc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n2Cc2ccc(Cl)cc2)ncn1 271743 US10065941, Compound R-050::US9732060, Compound R-050 P2X purinoceptor 3 Homo sapiens 14.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271743 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271743&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752102 378153569 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513771 CCOC(=O)c1cnc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(CC)c(=O)n2Cc2ccc(Cl)cc2)cc1Cl InChI=1S/C26H23Cl2N5O5/c1-3-32-25(35)31-24(33(26(32)36)15-16-5-7-17(27)8-6-16)30-18-9-11-19(12-10-18)38-22-13-21(28)20(14-29-22)23(34)37-4-2/h5-14H,3-4,15H2,1-2H3,(H,30,31,35) RWGMLUJYBSFWMB-UHFFFAOYSA-N 271744 US10065941, Compound R-053::US9732060, Compound R-053 P2X purinoceptor 3 Homo sapiens 52.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271744 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271744&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295507 378153570 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513772 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cc(Cl)c(cn3)C(O)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H19Cl2N5O5/c1-2-30-23(34)29-22(31(24(30)35)13-14-3-5-15(25)6-4-14)28-16-7-9-17(10-8-16)36-20-11-19(26)18(12-27-20)21(32)33/h3-12H,2,13H2,1H3,(H,32,33)(H,28,29,34) IURJIBYGKPLKIX-UHFFFAOYSA-N 271745 US10065941, Compound R-054::US9732060, Compound R-054 P2X purinoceptor 3 Homo sapiens 26.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271745 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271745&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295508 378153571 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513773 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cnccn3)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271746 US10065941, Compound R-055::US9732060, Compound R-055 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271746 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271746&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295509 378153572 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513774 CC(C)(Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cnccn3)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O InChI=1S/C25H22ClFN6O5/c1-25(2,21(34)35)14-33-23(36)31-22(32(24(33)37)13-15-3-5-16(26)6-4-15)30-17-7-8-19(18(27)11-17)38-20-12-28-9-10-29-20/h3-12H,13-14H2,1-2H3,(H,34,35)(H,30,31,36) ORCXKNLJBSZIKW-UHFFFAOYSA-N 271747 US10065941, Compound R-056::US9732060, Compound R-056 P2X purinoceptor 3 Homo sapiens 10.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271747 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271747&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295510 378153573 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513775 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cc(F)nc(F)c3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271748 US10065941, Compound R-057::US9732060, Compound R-057 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271748 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271748&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295511 378153574 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513776 COc1cc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n2Cc2ccc(Cl)cc2)cc(F)n1 271749 US10065941, Compound R-058::US9732060, Compound R-058 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271749 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271749&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295512 378153575 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513777 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ncccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O 271750 US10065941, Compound R-059::US9732060, Compound R-059 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271750 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271750&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295513 378153576 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513778 CC(C)(Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ncccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O InChI=1S/C25H23ClN6O5/c1-25(2,20(33)34)15-32-23(35)30-21(31(24(32)36)14-16-4-6-17(26)7-5-16)29-18-8-10-19(11-9-18)37-22-27-12-3-13-28-22/h3-13H,14-15H2,1-2H3,(H,33,34)(H,29,30,35) PRCLIANUHAPGBF-UHFFFAOYSA-N 271751 US10065941, Compound R-060::US9732060, Compound R-060 P2X purinoceptor 3 Homo sapiens 16.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271751 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271751&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295514 378153577 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513779 COc1nccc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n2Cc2ccc(Cl)cc2)n1 271752 US10065941, Compound R-061::US9732060, Compound R-061 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271752 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271752&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295516 378153578 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513780 CCOC(=O)[C@@H]1C[C@@H](C1)Oc1ccc(cc1)\N=c1/[nH]c(=O)n(CC)c(=O)n1Cc1ccc(Cl)cc1 271753 US10065941, Compound R-062::US9732060, Compound R-062 P2X purinoceptor 3 Homo sapiens 318 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271753 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271753&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295515 378153579 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513781 CCn1c(=O)[nH]\c(=N/c2ccc(O[C@H]3C[C@H](C3)C(O)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O 271754 US10065941, Compound R-063::US9732060, Compound R-063 P2X purinoceptor 3 Homo sapiens 456 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271754 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271754&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295517 378153580 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513782 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(C(=O)OC)c(Cl)n3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H21Cl2N5O5/c1-3-31-24(34)30-23(32(25(31)35)14-15-4-6-16(26)7-5-15)28-17-8-10-18(11-9-17)37-20-13-12-19(21(27)29-20)22(33)36-2/h4-13H,3,14H2,1-2H3,(H,28,30,34) BWPMVTKXOZPSEZ-UHFFFAOYSA-N 271755 US10065941, Compound R-064::US9732060, Compound R-064 P2X purinoceptor 3 Homo sapiens 12.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271755 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271755&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295519 378153581 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513783 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(C(O)=O)c(Cl)n3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H19Cl2N5O5/c1-2-30-23(34)29-22(31(24(30)35)13-14-3-5-15(25)6-4-14)27-16-7-9-17(10-8-16)36-19-12-11-18(21(32)33)20(26)28-19/h3-12H,2,13H2,1H3,(H,32,33)(H,27,29,34) HLESPNWKKHPTSG-UHFFFAOYSA-N 271756 US10065941, Compound R-066::US9732060, Compound R-066 P2X purinoceptor 3 Homo sapiens 58.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271756 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271756&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295518 378153582 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513784 CCc1[nH]c2ccc(cc2c1C)\N=c1/[nH]c(=O)n(C[C@H](C)C(=O)OC)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C26H26ClN5O4/c1-5-21-16(3)20-12-19(10-11-22(20)29-21)28-24-30-25(34)32(13-15(2)23(33)36-4)26(35)31(24)14-17-6-8-18(27)9-7-17/h6-12,15H,5,13-14H2,1-4H3/b28-19-/t15-/m0/s1 KHURNGCGIUDCAN-ZRAJOVRMSA-N 271757 US10065941, Compound R-068::US9732060, Compound R-068 P2X purinoceptor 3 Homo sapiens 40.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271757 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271757&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295520 378153583 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513785 CCc1[nH]c2ccc(cc2c1C)\N=c1/[nH]c(=O)n(CC(C)(C)C(=O)OC)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C27H30ClN5O4/c1-6-21-16(2)20-13-19(11-12-22(20)30-21)29-24-31-25(35)33(15-27(3,4)23(34)37-5)26(36)32(24)14-17-7-9-18(28)10-8-17/h7-13,30H,6,14-15H2,1-5H3,(H,29,31,35) LOFXMTHXCPJZPB-UHFFFAOYSA-N 271758 US10065941, Compound R-069::US9732060, Compound R-069 P2X purinoceptor 3 Homo sapiens 51.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271758 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271758&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295521 378153584 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513786 CC(C)(Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cc(F)nc(F)c3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O InChI=1S/C26H22ClF2N5O5/c1-26(2,22(35)36)14-34-24(37)32-23(33(25(34)38)13-15-3-5-16(27)6-4-15)30-17-7-9-18(10-8-17)39-19-11-20(28)31-21(29)12-19/h3-12H,13-14H2,1-2H3,(H,35,36)(H,30,32,37) BDVTWUFYGYQEGN-UHFFFAOYSA-N 271759 US10065941, Compound R-070::US9732060, Compound R-070 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271759 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271759&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295522 378153585 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513787 COc1cc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n2Cc2ccc(Cl)cc2)cc(F)n1 InChI=1S/C27H25ClFN5O6/c1-27(2,23(35)36)15-34-25(37)32-24(33(26(34)38)14-16-4-6-17(28)7-5-16)30-18-8-10-19(11-9-18)40-20-12-21(29)31-22(13-20)39-3/h4-13H,14-15H2,1-3H3,(H,35,36)(H,30,32,37) YIOQHMQYRLHCOW-UHFFFAOYSA-N 271760 US10065941, Compound R-071::US9732060, Compound R-071 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271760 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271760&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295523 378153586 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513788 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(OC3CCC3)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O 271761 US10065941, Compound R-072::US9732060, Compound R-072 P2X purinoceptor 3 Homo sapiens 16.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271761 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271761&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752298 378153587 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513789 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(OC3CCC3)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H28ClFN4O5/c1-26(2,22(33)36-3)15-32-24(34)30-23(31(25(32)35)14-16-7-9-17(27)10-8-16)29-18-11-12-21(20(28)13-18)37-19-5-4-6-19/h7-13,19H,4-6,14-15H2,1-3H3,(H,29,30,34) MRIYDBTXGOVCOP-UHFFFAOYSA-N 271762 US10065941, Compound R-073::US9732060, Compound R-073 P2X purinoceptor 3 Homo sapiens 31.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271762 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271762&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752294 378153588 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513790 CCc1[nH]c2ccc(cc2c1C)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C25H24ClN5O4/c1-4-20-15(3)19-11-18(9-10-21(19)28-20)27-23-29-24(34)31(12-14(2)22(32)33)25(35)30(23)13-16-5-7-17(26)8-6-16/h5-11,14H,4,12-13H2,1-3H3,(H,32,33)/b27-18-/t14-/m0/s1 STZAOFBEQZCXID-APVWPMNASA-N 271763 US10065941, Compound R-074::US9732060, Compound R-074 P2X purinoceptor 3 Homo sapiens 13.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271763 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271763&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295524 378153589 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513791 CCc1[nH]c2ccc(cc2c1C)\N=c1/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C26H28ClN5O4/c1-5-20-15(2)19-12-18(10-11-21(19)29-20)28-23-30-24(35)32(14-26(3,4)22(33)34)25(36)31(23)13-16-6-8-17(27)9-7-16/h6-12,29H,5,13-14H2,1-4H3,(H,33,34)(H,28,30,35) KYBRPBCGLDQTLV-UHFFFAOYSA-N 271764 US10065941, Compound R-075::US9732060, Compound R-075 P2X purinoceptor 3 Homo sapiens 13.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271764 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271764&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295532 378153590 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513792 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(OC3CCC3)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271765 US10065941, Compound R-076::US9732060, Compound R-076 P2X purinoceptor 3 Homo sapiens 13.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271765 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271765&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295525 378153591 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513793 CC(C)(Cn1c(=O)[nH]\c(=N/c2ccc(OC3CCC3)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O InChI=1S/C25H26ClFN4O5/c1-25(2,21(32)33)14-31-23(34)29-22(30(24(31)35)13-15-6-8-16(26)9-7-15)28-17-10-11-20(19(27)12-17)36-18-4-3-5-18/h6-12,18H,3-5,13-14H2,1-2H3,(H,32,33)(H,28,29,34) IIQSIVMLMRUNOP-UHFFFAOYSA-N 271766 US10065941, Compound R-077::US9732060, Compound R-077 P2X purinoceptor 3 Homo sapiens 24.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271766 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271766&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295526 378153592 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513794 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ncccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271767 US10065941, Compound R-078::US9732060, Compound R-078 P2X purinoceptor 3 Homo sapiens 10.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271767 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271767&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295528 378153593 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513795 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cncc(Cl)c3)cc2)n(Cc2ccc(Cl)cc2)c1=O 271768 US10065941, Compound R-079::US9732060, Compound R-079 P2X purinoceptor 3 Homo sapiens 11.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271768 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271768&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295527 378153594 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513796 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cncc(Cl)c3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C27H25Cl2N5O5/c1-27(2,23(35)38-3)16-34-25(36)32-24(33(26(34)37)15-17-4-6-18(28)7-5-17)31-20-8-10-21(11-9-20)39-22-12-19(29)13-30-14-22/h4-14H,15-16H2,1-3H3,(H,31,32,36) HGUDAHIKBGCKSI-UHFFFAOYSA-N 271769 US10065941, Compound R-080::US9732060, Compound R-080 P2X purinoceptor 3 Homo sapiens 13.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271769 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271769&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295538 378153595 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513797 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cncc(Cl)c3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271770 US10065941, Compound R-081::US9732060, Compound R-081 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271770 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271770&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295533 378153596 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513798 CC(C)(Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cncc(Cl)c3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O InChI=1S/C26H23Cl2N5O5/c1-26(2,22(34)35)15-33-24(36)31-23(32(25(33)37)14-16-3-5-17(27)6-4-16)30-19-7-9-20(10-8-19)38-21-11-18(28)12-29-13-21/h3-13H,14-15H2,1-2H3,(H,34,35)(H,30,31,36) ZWEGJKPZSTUVMJ-UHFFFAOYSA-N 271771 US10065941, Compound R-082::US9732060, Compound R-082 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271771 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271771&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295529 378153597 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513799 OCC1(Cn2c(=O)[nH]\c(=N/c3ccc(Oc4ncccc4F)cc3)n(Cc3ccc(Cl)cc3)c2=O)COC1 InChI=1S/C26H23ClFN5O5/c27-18-5-3-17(4-6-18)12-32-23(31-24(35)33(25(32)36)13-26(14-34)15-37-16-26)30-19-7-9-20(10-8-19)38-22-21(28)2-1-11-29-22/h1-11,34H,12-16H2,(H,30,31,35) FCJYWKKJQAQIJE-UHFFFAOYSA-N 271772 US10065941, Compound R-083::US9732060, Compound R-083 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271772 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271772&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295530 378153598 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513800 OCC1(Cn2c(=O)[nH]\c(=N/c3ccc(Oc4ccc(F)cn4)cc3)n(Cc3ccc(Cl)cc3)c2=O)COC1 InChI=1S/C26H23ClFN5O5/c27-18-3-1-17(2-4-18)12-32-23(31-24(35)33(25(32)36)13-26(14-34)15-37-16-26)30-20-6-8-21(9-7-20)38-22-10-5-19(28)11-29-22/h1-11,34H,12-16H2,(H,30,31,35) CMKXPIWSJLUWST-UHFFFAOYSA-N 271773 US10065941, Compound R-084::US9732060, Compound R-084 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271773 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271773&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295531 378153599 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513801 COc1ccc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n2Cc2ccc(Cl)cc2)nn1 271774 US10065941, Compound R-085::US9732060, Compound R-085 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271774 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271774&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295534 378153600 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513802 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccnc(Cl)c3)cc2)n(Cc2ccc(Cl)cc2)c1=O 271775 US10065941, Compound R-086::US9732060, Compound R-086 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271775 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271775&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295539 378153601 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513803 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccnc(Cl)c3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C27H25Cl2N5O5/c1-27(2,23(35)38-3)16-34-25(36)32-24(33(26(34)37)15-17-4-6-18(28)7-5-17)31-19-8-10-20(11-9-19)39-21-12-13-30-22(29)14-21/h4-14H,15-16H2,1-3H3,(H,31,32,36) ZNXIRIAVXRMFJG-UHFFFAOYSA-N 271776 US10065941, Compound R-087::US9732060, Compound R-087 P2X purinoceptor 3 Homo sapiens 12.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271776 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271776&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295535 378153602 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513804 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccnc(Cl)c3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271777 US10065941, Compound R-088::US9732060, Compound R-088 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271777 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271777&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295542 378153603 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513805 CC(C)(Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccnc(Cl)c3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O InChI=1S/C26H23Cl2N5O5/c1-26(2,22(34)35)15-33-24(36)31-23(32(25(33)37)14-16-3-5-17(27)6-4-16)30-18-7-9-19(10-8-18)38-20-11-12-29-21(28)13-20/h3-13H,14-15H2,1-2H3,(H,34,35)(H,30,31,36) GQLVLAMFWPKKMW-UHFFFAOYSA-N 271778 US10065941, Compound R-089::US9732060, Compound R-089 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271778 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271778&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295536 378153604 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513806 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(O[C@H](C)C(F)(F)F)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O 271779 US10065941, Compound R-090::US9732060, Compound R-090 P2X purinoceptor 3 Homo sapiens 70.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271779 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271779&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295537 378153605 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513807 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(O[C@H](C)C(F)(F)F)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O 271780 US10065941, Compound R-091::US9732060, Compound R-091 P2X purinoceptor 3 Homo sapiens 108 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271780 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271780&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295544 378153606 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513808 CC(C)(Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cc(Cl)ncn3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O InChI=1S/C25H22Cl2N6O5/c1-25(2,21(34)35)13-33-23(36)31-22(32(24(33)37)12-15-3-5-16(26)6-4-15)30-17-7-9-18(10-8-17)38-20-11-19(27)28-14-29-20/h3-11,14H,12-13H2,1-2H3,(H,34,35)(H,30,31,36) YEDBGRDFLMHAGG-UHFFFAOYSA-N 271781 US10065941, Compound R-092::US9732060, Compound R-092 P2X purinoceptor 3 Homo sapiens 10.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271781 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271781&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295541 378153607 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513809 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(O[C@H](C)C(F)(F)F)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271782 US10065941, Compound R-093::US9732060, Compound R-093 P2X purinoceptor 3 Homo sapiens 13.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271782 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271782&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295543 378153608 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513810 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(O[C@H](C)C(F)(F)F)c(O[C@H](C)C(F)(F)F)c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271783 US10065941, Compound R-094::US9732060, Compound R-094 P2X purinoceptor 3 Homo sapiens 29.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271783 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271783&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295546 378153609 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513811 C[C@@H](Oc1ccc(cc1F)\N=c1/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1)C(F)(F)F 271784 US10065941, Compound R-095::US9732060, Compound R-095 P2X purinoceptor 3 Homo sapiens 45.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271784 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271784&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295540 378153610 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513812 C[C@@H](Oc1ccc(cc1O[C@H](C)C(F)(F)F)\N=c1/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1)C(F)(F)F 271785 US10065941, Compound R-096::US9732060, Compound R-096 P2X purinoceptor 3 Homo sapiens 156 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271785 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271785&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295547 378153611 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513813 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(O[C@H](C)C(F)(F)F)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O 271786 US10065941, Compound R-097::US9732060, Compound R-097 P2X purinoceptor 3 Homo sapiens 212 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271786 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271786&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295545 378153612 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513814 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(O[C@H](C)C(F)(F)F)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271787 US10065941, Compound R-098::US9732060, Compound R-098 P2X purinoceptor 3 Homo sapiens 80.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271787 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271787&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295548 378153613 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513815 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccnc(c3)C#N)cc2)n(Cc2ccc(Cl)cc2)c1=O 271788 US10065941, Compound R-099::US9732060, Compound R-099 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271788 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271788&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295549 378153614 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513816 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccnc(c3)C#N)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C28H25ClN6O5/c1-28(2,24(36)39-3)17-35-26(37)33-25(34(27(35)38)16-18-4-6-19(29)7-5-18)32-20-8-10-22(11-9-20)40-23-12-13-31-21(14-23)15-30/h4-14H,16-17H2,1-3H3,(H,32,33,37) KBPOYCAUDGOMJM-UHFFFAOYSA-N 271789 US10065941, Compound R-100::US9732060, Compound R-100 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271789 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271789&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295550 378153615 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513817 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(N3CCOCC3)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O 271790 US10065941, Compound R-101::US9732060, Compound R-101 P2X purinoceptor 3 Homo sapiens 201 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271790 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271790&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752381 378153616 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513818 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(N3CCOCC3)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C27H32ClN5O5/c1-18-15-21(9-10-22(18)31-11-13-38-14-12-31)29-24-30-25(35)33(17-27(2,3)23(34)37-4)26(36)32(24)16-19-5-7-20(28)8-6-19/h5-10,15H,11-14,16-17H2,1-4H3,(H,29,30,35) IBAISRLJYOJERF-UHFFFAOYSA-N 271791 US10065941, Compound R-102::US9732060, Compound R-102 P2X purinoceptor 3 Homo sapiens 100.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271791 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271791&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752359 378153617 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513819 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccnc(c3)C(O)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C28H26ClN5O7/c1-28(2,24(37)40-3)16-34-26(38)32-25(33(27(34)39)15-17-4-6-18(29)7-5-17)31-19-8-10-20(11-9-19)41-21-12-13-30-22(14-21)23(35)36/h4-14H,15-16H2,1-3H3,(H,35,36)(H,31,32,38) SCZCBRJAEQZYSI-UHFFFAOYSA-N 271792 US10065941, Compound R-105::US9732060, Compound R-105 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271792 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271792&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295551 378153618 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513820 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(N3CCOCC3)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O 271793 US10065941, Compound R-106::US9732060, Compound R-106 P2X purinoceptor 3 Homo sapiens 379 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271793 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271793&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752214 378153619 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513821 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(N3CCOCC3)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H29ClFN5O5/c1-26(2,22(34)37-3)16-33-24(35)30-23(32(25(33)36)15-17-4-6-18(27)7-5-17)29-19-8-9-21(20(28)14-19)31-10-12-38-13-11-31/h4-9,14H,10-13,15-16H2,1-3H3,(H,29,30,35) QUWOAYIUOXHNOP-UHFFFAOYSA-N 271794 US10065941, Compound R-107::US9732060, Compound R-107 P2X purinoceptor 3 Homo sapiens 217 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271794 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271794&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752215 378153620 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513822 CC(C)(Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccnc(c3)C#N)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O InChI=1S/C27H23ClN6O5/c1-27(2,23(35)36)16-34-25(37)32-24(33(26(34)38)15-17-3-5-18(28)6-4-17)31-19-7-9-21(10-8-19)39-22-11-12-30-20(13-22)14-29/h3-13H,15-16H2,1-2H3,(H,35,36)(H,31,32,37) ZIUOCROSMYZZSW-UHFFFAOYSA-N 271795 US10065941, Compound R-108::US9732060, Compound R-108 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271795 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271795&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295552 378153621 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513823 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cnccn3)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O 271796 US10065941, Compound R-111::US9732060, Compound R-111 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271796 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271796&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295559 378153622 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513824 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3noc(C)n3)cc2)n(Cc2ccc(Cl)cc2)c1=O 271797 US10065941, Compound R-112::US9732060, Compound R-112 P2X purinoceptor 3 Homo sapiens 17.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271797 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271797&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295553 378153623 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513825 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3noc(C)n3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H25ClN6O6/c1-15-27-22(30-38-15)37-19-11-9-18(10-12-19)28-21-29-23(34)32(14-25(2,3)20(33)36-4)24(35)31(21)13-16-5-7-17(26)8-6-16/h5-12H,13-14H2,1-4H3,(H,28,29,34) ZQOIFPNWZJAAMK-UHFFFAOYSA-N 271798 US10065941, Compound R-113::US9732060, Compound R-113 P2X purinoceptor 3 Homo sapiens 13.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271798 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271798&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295560 378153624 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513826 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3noc(C)n3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271799 US10065941, Compound R-114::US9732060, Compound R-114 P2X purinoceptor 3 Homo sapiens 39.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271799 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271799&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295554 378153625 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513827 Cc1nc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n2Cc2ccc(Cl)cc2)no1 InChI=1S/C24H23ClN6O6/c1-14-26-21(29-37-14)36-18-10-8-17(9-11-18)27-20-28-22(34)31(13-24(2,3)19(32)33)23(35)30(20)12-15-4-6-16(25)7-5-15/h4-11H,12-13H2,1-3H3,(H,32,33)(H,27,28,34) UJLMUALVXSNBRM-UHFFFAOYSA-N 271800 US10065941, Compound R-115::US9732060, Compound R-115 P2X purinoceptor 3 Homo sapiens 65.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271800 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271800&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295568 378153626 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513828 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cncc(F)c3)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271801 US10065941, Compound R-116::US9732060, Compound R-116 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271801 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271801&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295555 378153627 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513829 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cncc(F)c3)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271802 US10065941, Compound R-117::US9732060, Compound R-117 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271802 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271802&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295569 378153628 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513830 Cc1cc(ccc1Oc1cncc(F)c1)\N=c1/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C27H25ClFN5O5/c1-16-10-20(8-9-22(16)39-21-11-19(29)12-30-13-21)31-24-32-25(37)34(15-27(2,3)23(35)36)26(38)33(24)14-17-4-6-18(28)7-5-17/h4-13H,14-15H2,1-3H3,(H,35,36)(H,31,32,37) WZHWWUIQQFQHAG-UHFFFAOYSA-N 271803 US10065941, Compound R-118::US9732060, Compound R-118 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271803 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271803&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295561 378153629 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513831 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cccnn3)cc2)n(Cc2ccc(Cl)cc2)c1=O 271804 US10065941, Compound R-119::US9732060, Compound R-119 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271804 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271804&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295557 378153630 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513832 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cccnn3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271805 US10065941, Compound R-120::US9732060, Compound R-120 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271805 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271805&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295556 378153631 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513833 CC(C)(Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cncc(F)c3)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O InChI=1S/C26H22ClF2N5O5/c1-26(2,22(35)36)14-34-24(37)32-23(33(25(34)38)13-15-3-5-16(27)6-4-15)31-18-7-8-21(20(29)10-18)39-19-9-17(28)11-30-12-19/h3-12H,13-14H2,1-2H3,(H,35,36)(H,31,32,37) XSOKLAWFOKUOIO-UHFFFAOYSA-N 271806 US10065941, Compound R-121::US9732060, Compound R-121 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271806 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271806&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295563 378153632 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513834 COC(=O)[C@H](C)[C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3cnccn3)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O 271807 US10065941, Compound R-122::US9732060, Compound R-122 P2X purinoceptor 3 Homo sapiens 13.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271807 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271807&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295564 378153633 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513835 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccnc(c3)C#N)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271808 US10065941, Compound R-123::US9732060, Compound R-123 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271808 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271808&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295562 378153634 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513836 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cc(Cl)ncn3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271809 US10065941, Compound R-124::US9732060, Compound R-124 P2X purinoceptor 3 Homo sapiens 9.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271809 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271809&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295558 378153635 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513837 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3cnccn3)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271810 US10065941, Compound R-125::US9732060, Compound R-125 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271810 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271810&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295570 378153636 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513838 CC(C)(Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cc(O)nc(F)c3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O InChI=1S/C26H23ClFN5O6/c1-26(2,22(35)36)14-33-24(37)31-23(32(25(33)38)13-15-3-5-16(27)6-4-15)29-17-7-9-18(10-8-17)39-19-11-20(28)30-21(34)12-19/h3-12H,13-14H2,1-2H3,(H,30,34)(H,35,36)(H,29,31,37) CMJTXAPIMGIDHG-UHFFFAOYSA-N 271811 US10065941, Compound R-126::US9732060, Compound R-126 P2X purinoceptor 3 Homo sapiens 10.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271811 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271811&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295566 378153637 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513839 CCc1[nH]c2ccc(cc2c1C)\N=c1/[nH]c(=O)n([C@@H](C)[C@@H](C)C(=O)OC)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C27H28ClN5O4/c1-6-22-16(3)21-13-20(11-12-23(21)30-22)29-25-31-26(35)33(17(4)15(2)24(34)37-5)27(36)32(25)14-18-7-9-19(28)10-8-18/h7-13,15,17H,6,14H2,1-5H3/b29-20-/t15-,17+/m1/s1 FDWOMSKDNMJJPE-RDGVBXFPSA-N 271812 US10065941, Compound R-127::US9732060, Compound R-127 P2X purinoceptor 3 Homo sapiens 90.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271812 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271812&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295575 378153638 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513840 CCc1[nH]c2ccc(cc2c1C)\N=c1/[nH]c(=O)n([C@@H](C)[C@@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C26H26ClN5O4/c1-5-21-15(3)20-12-19(10-11-22(20)29-21)28-24-30-25(35)32(16(4)14(2)23(33)34)26(36)31(24)13-17-6-8-18(27)9-7-17/h6-12,14,16H,5,13H2,1-4H3,(H,33,34)/b28-19-/t14-,16+/m1/s1 XDFRWSJUTDCGQB-GLXKCUSFSA-N 271813 US10065941, Compound R-128::US9732060, Compound R-128 P2X purinoceptor 3 Homo sapiens 11.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271813 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271813&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752293 378153639 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513841 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cnccn3)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C27H27ClN6O5/c1-17-13-20(9-10-21(17)39-22-14-29-11-12-30-22)31-24-32-25(36)34(16-27(2,3)23(35)38-4)26(37)33(24)15-18-5-7-19(28)8-6-18/h5-14H,15-16H2,1-4H3,(H,31,32,36) RKIMLVWCCFPVCI-UHFFFAOYSA-N 271814 US10065941, Compound R-129::US9732060, Compound R-129 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271814 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271814&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295565 378153640 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513842 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cnccn3)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271815 US10065941, Compound R-130::US9732060, Compound R-130 P2X purinoceptor 3 Homo sapiens 9.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271815 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271815&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295571 378153641 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513843 Cc1cc(ccc1Oc1cnccn1)\N=c1/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C26H25ClN6O5/c1-16-12-19(8-9-20(16)38-21-13-28-10-11-29-21)30-23-31-24(36)33(15-26(2,3)22(34)35)25(37)32(23)14-17-4-6-18(27)7-5-17/h4-13H,14-15H2,1-3H3,(H,34,35)(H,30,31,36) SWFJHVFHEQBLND-UHFFFAOYSA-N 271816 US10065941, Compound R-131::US9732060, Compound R-131 P2X purinoceptor 3 Homo sapiens 9.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271816 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271816&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295567 378153642 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513844 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ncc(C)s3)cc2)n(Cc2ccc(Cl)cc2)c1=O 271817 US10065941, Compound R-132::US9732060, Compound R-132 P2X purinoceptor 3 Homo sapiens 10.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271817 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271817&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295572 378153643 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513845 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ncc(C)s3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271818 US10065941, Compound R-133::US9732060, Compound R-133 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271818 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271818&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295576 378153644 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513846 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ncns3)cc2)n(Cc2ccc(Cl)cc2)c1=O 271819 US10065941, Compound R-134::US9732060, Compound R-134 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271819 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271819&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295573 378153645 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513847 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3nc(C)ns3)cc2)n(Cc2ccc(Cl)cc2)c1=O 271820 US10065941, Compound R-135::US9732060, Compound R-135 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271820 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271820&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295578 378153646 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513848 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ncns3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H23ClN6O5S/c1-24(2,19(32)35-3)13-31-21(33)29-20(30(23(31)34)12-15-4-6-16(25)7-5-15)28-17-8-10-18(11-9-17)36-22-26-14-27-37-22/h4-11,14H,12-13H2,1-3H3,(H,28,29,33) XODHWXOHXJMVJO-UHFFFAOYSA-N 271821 US10065941, Compound R-136::US9732060, Compound R-136 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271821 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271821&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752142 378153647 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513849 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3nc(C)ns3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H25ClN6O5S/c1-15-27-23(38-30-15)37-19-11-9-18(10-12-19)28-21-29-22(34)32(14-25(2,3)20(33)36-4)24(35)31(21)13-16-5-7-17(26)8-6-16/h5-12H,13-14H2,1-4H3,(H,28,29,34) CNCYBVBAYGXZCL-UHFFFAOYSA-N 271822 US10065941, Compound R-137::US9732060, Compound R-137 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271822 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271822&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752139 378153648 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513850 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(N3CCCCC3)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O 271823 US10065941, Compound R-138::US9732060, Compound R-138 P2X purinoceptor 3 Homo sapiens 78.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271823 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271823&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752144 378153649 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513851 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(N3CCCCC3)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C28H34ClN5O4/c1-19-16-22(12-13-23(19)32-14-6-5-7-15-32)30-25-31-26(36)34(18-28(2,3)24(35)38-4)27(37)33(25)17-20-8-10-21(29)11-9-20/h8-13,16H,5-7,14-15,17-18H2,1-4H3,(H,30,31,36) CKTYKROLHIXLDK-UHFFFAOYSA-N 271824 US10065941, Compound R-139::US9732060, Compound R-139 P2X purinoceptor 3 Homo sapiens 119 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271824 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271824&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752138 378153650 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513852 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(N3CCCCC3)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O 271825 US10065941, Compound R-140::US9732060, Compound R-140 P2X purinoceptor 3 Homo sapiens 37.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271825 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271825&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752143 378153651 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513853 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(N3CCCCC3)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C27H31ClFN5O4/c1-27(2,23(35)38-3)17-34-25(36)31-24(33(26(34)37)16-18-7-9-19(28)10-8-18)30-20-11-12-22(21(29)15-20)32-13-5-4-6-14-32/h7-12,15H,4-6,13-14,16-17H2,1-3H3,(H,30,31,36) AGMBICPMWBNFMR-UHFFFAOYSA-N 271826 US10065941, Compound R-141::US9732060, Compound R-141 P2X purinoceptor 3 Homo sapiens 47.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271826 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271826&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752299 378153652 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513854 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(N3CCCCC3)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271827 US10065941, Compound R-142::US9732060, Compound R-142 P2X purinoceptor 3 Homo sapiens 69.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271827 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271827&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295577 378153653 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513855 Cc1cc(ccc1N1CCCCC1)\N=c1/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C27H32ClN5O4/c1-18-15-21(11-12-22(18)31-13-5-4-6-14-31)29-24-30-25(36)33(17-27(2,3)23(34)35)26(37)32(24)16-19-7-9-20(28)10-8-19/h7-12,15H,4-6,13-14,16-17H2,1-3H3,(H,34,35)(H,29,30,36) JKKCFNJXHOZGNW-UHFFFAOYSA-N 271828 US10065941, Compound R-143::US9732060, Compound R-143 P2X purinoceptor 3 Homo sapiens 97.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271828 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271828&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295574 378153654 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513856 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3nc4ccccc4o3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271829 US10065941, Compound R-144::US9732060, Compound R-144 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271829 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271829&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121285495 378153655 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513857 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3nc(ns3)C(F)(F)F)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271830 US10065941, Compound R-145::US9732060, Compound R-145 P2X purinoceptor 3 Homo sapiens 11.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271830 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271830&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295580 378153656 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513858 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(N3CCCCC3)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271831 US10065941, Compound R-146::US9732060, Compound R-146 P2X purinoceptor 3 Homo sapiens 33.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271831 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271831&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295579 378153657 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513859 CC(C)(Cn1c(=O)[nH]\c(=N/c2ccc(N3CCCCC3)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O InChI=1S/C26H29ClFN5O4/c1-26(2,22(34)35)16-33-24(36)30-23(32(25(33)37)15-17-6-8-18(27)9-7-17)29-19-10-11-21(20(28)14-19)31-12-4-3-5-13-31/h6-11,14H,3-5,12-13,15-16H2,1-2H3,(H,34,35)(H,29,30,36) GFTDAWBEZBEPMF-UHFFFAOYSA-N 271832 US10065941, Compound R-147::US9732060, Compound R-147 P2X purinoceptor 3 Homo sapiens 51.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271832 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271832&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295581 378153658 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513860 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cccnn3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H25ClN6O5/c1-26(2,22(34)37-3)16-33-24(35)30-23(32(25(33)36)15-17-6-8-18(27)9-7-17)29-19-10-12-20(13-11-19)38-21-5-4-14-28-31-21/h4-14H,15-16H2,1-3H3,(H,29,30,35) ISPFGUTVHDTCJL-UHFFFAOYSA-N 271833 US10065941, Compound R-148::US9732060, Compound R-148 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271833 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271833&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295587 378153659 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513861 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ncc(C)s3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H26ClN5O5S/c1-16-13-28-24(38-16)37-20-11-9-19(10-12-20)29-22-30-23(34)32(15-26(2,3)21(33)36-4)25(35)31(22)14-17-5-7-18(27)8-6-17/h5-13H,14-15H2,1-4H3,(H,29,30,34) PMBCKYFCNMPDLZ-UHFFFAOYSA-N 271834 US10065941, Compound R-149::US9732060, Compound R-149 P2X purinoceptor 3 Homo sapiens 12.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271834 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271834&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295582 378153660 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513862 COC(=O)[C@H](C)[C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3ccnc(Cl)c3)cc2)n(Cc2ccc(Cl)cc2)c1=O 271835 US10065941, Compound R-150::US9732060, Compound R-150 P2X purinoceptor 3 Homo sapiens 18.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271835 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271835&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295583 378153661 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513863 CC(C)(Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cccnn3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O InChI=1S/C25H23ClN6O5/c1-25(2,21(33)34)15-32-23(35)29-22(31(24(32)36)14-16-5-7-17(26)8-6-16)28-18-9-11-19(12-10-18)37-20-4-3-13-27-30-20/h3-13H,14-15H2,1-2H3,(H,33,34)(H,28,29,35) QQBSQBSYKBIUHZ-UHFFFAOYSA-N 271836 US10065941, Compound R-151::US9732060, Compound R-151 P2X purinoceptor 3 Homo sapiens 11.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271836 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271836&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295584 378153662 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513864 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(CO)nc3)cc2)n(Cc2ccc(Cl)cc2)c1=O 271837 US10065941, Compound R-152::US9732060, Compound R-152 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271837 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271837&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295585 378153663 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513865 Cc1cnc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n2Cc2ccc(Cl)cc2)s1 InChI=1S/C25H24ClN5O5S/c1-15-12-27-23(37-15)36-19-10-8-18(9-11-19)28-21-29-22(34)31(14-25(2,3)20(32)33)24(35)30(21)13-16-4-6-17(26)7-5-16/h4-12H,13-14H2,1-3H3,(H,32,33)(H,28,29,34) RHUMXFQDEKHVKS-UHFFFAOYSA-N 271838 US10065941, Compound R-153::US9732060, Compound R-153 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271838 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271838&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295586 378153664 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513866 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3ccnc(Cl)c3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271839 US10065941, Compound R-154::US9732060, Compound R-154 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271839 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271839&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295588 378153665 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513867 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(CO)nc3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271840 US10065941, Compound R-155::US9732060, Compound R-155 P2X purinoceptor 3 Homo sapiens 10.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271840 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271840&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295589 378153666 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513868 COC(=O)[C@H](C)[C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3cc(F)nc(F)c3)cc2)n(Cc2ccc(Cl)cc2)c1=O 271841 US10065941, Compound R-156::US9732060, Compound R-156 P2X purinoceptor 3 Homo sapiens 35.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271841 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271841&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295591 378153667 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513869 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3cc(F)nc(F)c3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271842 US10065941, Compound R-157::US9732060, Compound R-157 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271842 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271842&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295590 378153668 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513870 COC(=O)[C@H](C)[C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3cnccn3)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O 271843 US10065941, Compound R-158::US9732060, Compound R-158 P2X purinoceptor 3 Homo sapiens 12.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271843 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271843&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295595 378153669 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513871 COC(=O)[C@H](C)[C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3cnc(Cl)cn3)cc2)n(Cc2ccc(Cl)cc2)c1=O 271844 US10065941, Compound R-159::US9732060, Compound R-159 P2X purinoceptor 3 Homo sapiens 18.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271844 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271844&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295592 378153670 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513872 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3nc(C)ns3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271845 US10065941, Compound R-160::US9732060, Compound R-160 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271845 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271845&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295593 378153671 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513873 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3cnccn3)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271846 US10065941, Compound R-161::US9732060, Compound R-161 P2X purinoceptor 3 Homo sapiens 10.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271846 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271846&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295594 378153672 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513874 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3cnc(Cl)cn3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271847 US10065941, Compound R-162::US9732060, Compound R-162 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271847 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271847&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295596 378153673 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513875 CC(C)(Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ncns3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O InChI=1S/C23H21ClN6O5S/c1-23(2,18(31)32)12-30-20(33)28-19(29(22(30)34)11-14-3-5-15(24)6-4-14)27-16-7-9-17(10-8-16)35-21-25-13-26-36-21/h3-10,13H,11-12H2,1-2H3,(H,31,32)(H,27,28,33) OULBKUOAELQZGM-UHFFFAOYSA-N 271848 US10065941, Compound R-163::US9732060, Compound R-163 P2X purinoceptor 3 Homo sapiens 14.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271848 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271848&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295597 378153674 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513876 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ncccn3)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271849 US10065941, Compound R-164::US9732060, Compound R-164 P2X purinoceptor 3 Homo sapiens 10.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271849 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271849&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295598 378153675 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513877 CC(C)(Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ncccn3)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O InChI=1S/C25H22ClFN6O5/c1-25(2,20(34)35)14-33-23(36)31-21(32(24(33)37)13-15-4-6-16(26)7-5-15)30-17-8-9-19(18(27)12-17)38-22-28-10-3-11-29-22/h3-12H,13-14H2,1-2H3,(H,34,35)(H,30,31,36) RFSGUIFDSOVYAO-UHFFFAOYSA-N 271850 US10065941, Compound R-165::US9732060, Compound R-165 P2X purinoceptor 3 Homo sapiens 14.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271850 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271850&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295603 378153676 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513878 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(Cl)nc3C#N)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H18Cl2N6O3/c1-2-31-23(33)30-22(32(24(31)34)14-15-3-5-16(25)6-4-15)28-17-7-9-18(10-8-17)35-20-11-12-21(26)29-19(20)13-27/h3-12H,2,14H2,1H3,(H,28,30,33) ARHZRZCBKBPGBZ-UHFFFAOYSA-N 271851 US10065941, Compound R-166::US9732060, Compound R-166 P2X purinoceptor 3 Homo sapiens 48.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271851 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271851&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295600 378153677 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513879 COC(=O)[C@H](C)[C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3cnccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O 271852 US10065941, Compound R-167::US9732060, Compound R-167 P2X purinoceptor 3 Homo sapiens 11.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271852 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271852&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295599 378153678 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513880 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3cnccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271853 US10065941, Compound R-168::US9732060, Compound R-168 P2X purinoceptor 3 Homo sapiens 17.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271853 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271853&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295605 378153679 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513881 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(Cl)nc3C(O)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H19Cl2N5O5/c1-2-30-23(34)29-22(31(24(30)35)13-14-3-5-15(25)6-4-14)27-16-7-9-17(10-8-16)36-18-11-12-19(26)28-20(18)21(32)33/h3-12H,2,13H2,1H3,(H,32,33)(H,27,29,34) XVYZHOYKZRXTDO-UHFFFAOYSA-N 271854 US10065941, Compound R-169::US9732060, Compound R-169 P2X purinoceptor 3 Homo sapiens 304 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271854 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271854&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295602 378153680 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513882 Fc1ccc(Oc2ccc(cc2)\N=c2/[nH]c(=O)[nH]c(=O)n2Cc2ccc(Cl)cc2)nc1 InChI=1S/C21H15ClFN5O3/c22-14-3-1-13(2-4-14)12-28-19(26-20(29)27-21(28)30)25-16-6-8-17(9-7-16)31-18-10-5-15(23)11-24-18/h1-11H,12H2,(H2,25,26,27,29,30) OOPDVFQPCDWAPL-UHFFFAOYSA-N 271855 US10065941, Compound R-170::US9732060, Compound R-170 P2X purinoceptor 3 Homo sapiens 193 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271855 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271855&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295601 378153681 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513883 CCOC(=O)C[C@H](O)Cn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(Cl)c2)n(Cc2ccc(Cl)cc2)c1=O 271856 US10065941, Compound R-171::US9732060, Compound R-171 P2X purinoceptor 3 Homo sapiens 33.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271856 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271856&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295607 378153682 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513884 CCOC(=O)C[C@H](O)Cn1c(=O)[nH]\c(=N/c2ccc3oc(CC)c(C)c3c2)n(Cc2ccc(Cl)cc2)c1=O 271857 US10065941, Compound R-172::US9732060, Compound R-172 P2X purinoceptor 3 Homo sapiens 33.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271857 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271857&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295604 378153683 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513885 CCc1oc2ccc(cc2c1C)\N=c1/[nH]c(=O)[nH]c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C21H19ClN4O3/c1-3-17-12(2)16-10-15(8-9-18(16)29-17)23-19-24-20(27)25-21(28)26(19)11-13-4-6-14(22)7-5-13/h4-10H,3,11H2,1-2H3,(H2,23,24,25,27,28) URHKDBSSKFINEU-UHFFFAOYSA-N 271858 US10065941, Compound R-173::US9732060, Compound R-173 P2X purinoceptor 3 Homo sapiens 376 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271858 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271858&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295606 378153684 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513886 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(C)nn3)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O 271859 US10065941, Compound R-174::US9732060, Compound R-174 P2X purinoceptor 3 Homo sapiens 10.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271859 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271859&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295608 378153685 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513887 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(C)nn3)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C27H26ClFN6O5/c1-16-5-12-22(33-32-16)40-21-11-10-19(13-20(21)29)30-24-31-25(37)35(15-27(2,3)23(36)39-4)26(38)34(24)14-17-6-8-18(28)9-7-17/h5-13H,14-15H2,1-4H3,(H,30,31,37) JHKNZMKKBIVIPS-UHFFFAOYSA-N 271860 US10065941, Compound R-175::US9732060, Compound R-175 P2X purinoceptor 3 Homo sapiens 19.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271860 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271860&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295610 378153686 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513888 CC(C)(Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cnc(cn3)C(F)(F)F)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O InChI=1S/C26H22ClF3N6O5/c1-25(2,21(37)38)14-36-23(39)34-22(35(24(36)40)13-15-3-5-16(27)6-4-15)33-17-7-9-18(10-8-17)41-20-12-31-19(11-32-20)26(28,29)30/h3-12H,13-14H2,1-2H3,(H,37,38)(H,33,34,39) YMWOXTBSFQHULD-UHFFFAOYSA-N 271861 US10065941, Compound R-176::US9732060, Compound R-176 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271861 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271861&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295609 378153687 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513889 COc1cc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n([C@@H](C)[C@@H](C)C(O)=O)c(=O)n2Cc2ccc(Cl)cc2)cc(F)n1 271862 US10065941, Compound R-177::US9732060, Compound R-177 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271862 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271862&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295611 378153688 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513890 CCc1oc2ccc(cc2c1C)\N=c1/[nH]c(=O)n(C[C@@H](O)CC(O)=O)c(=O)n1Cc1ccc(Cl)cc1 271863 US10065941, Compound R-178::US9732060, Compound R-178 P2X purinoceptor 3 Homo sapiens 45.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271863 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271863&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295612 378153689 C03834 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513891 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(C[C@@H](O)CC(O)=O)c(=O)n1Cc1ccc(Cl)cc1 271864 US10065941, Compound R-179::US9732060, Compound R-179 P2X purinoceptor 3 Homo sapiens 56.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271864 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271864&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752380 378153690 C03834 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513892 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(C)nn3)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271865 US10065941, Compound R-180::US9732060, Compound R-180 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271865 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271865&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295613 378153691 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513893 Cc1ccc(Oc2ccc(cc2F)\N=c2/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n2Cc2ccc(Cl)cc2)nn1 InChI=1S/C26H24ClFN6O5/c1-15-4-11-21(32-31-15)39-20-10-9-18(12-19(20)28)29-23-30-24(37)34(14-26(2,3)22(35)36)25(38)33(23)13-16-5-7-17(27)8-6-16/h4-12H,13-14H2,1-3H3,(H,35,36)(H,29,30,37) YGAKZTVQVXSYJE-UHFFFAOYSA-N 271866 US10065941, Compound R-181::US9732060, Compound R-181 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271866 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271866&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295614 378153692 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513894 COC(=O)[C@H](C)[C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3ncc(C)s3)cc2)n(Cc2ccc(Cl)cc2)c1=O 271867 US10065941, Compound R-182::US9732060, Compound R-182 P2X purinoceptor 3 Homo sapiens 26.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271867 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271867&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295615 378153693 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513895 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3ncc(C)s3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271868 US10065941, Compound R-183::US9732060, Compound R-183 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271868 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271868&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295616 378153694 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513896 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cncc(C)c3)cc2)n(Cc2ccc(Cl)cc2)c1=O 271869 US10065941, Compound R-184::US9732060, Compound R-184 P2X purinoceptor 3 Homo sapiens 10.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271869 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271869&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295617 378153695 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513897 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cncc(C)c3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271870 US10065941, Compound R-185::US9732060, Compound R-185 P2X purinoceptor 3 Homo sapiens 12.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271870 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271870&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295618 378153696 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513898 COC(=O)[C@H](C)[C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3cncc(F)c3)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O 271871 US10065941, Compound R-186::US9732060, Compound R-186 P2X purinoceptor 3 Homo sapiens 26.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271871 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271871&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295619 378153697 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513899 COC(=O)[C@H](C)[C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3cncc(F)c3)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O 271872 US10065941, Compound R-187::US9732060, Compound R-187 P2X purinoceptor 3 Homo sapiens 21.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271872 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271872&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295620 378153698 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513900 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3cncc(F)c3)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271873 US10065941, Compound R-188::US9732060, Compound R-188 P2X purinoceptor 3 Homo sapiens 9.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271873 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271873&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295622 378153699 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513901 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3cncc(F)c3)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271874 US10065941, Compound R-189::US9732060, Compound R-189 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271874 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271874&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295623 378153700 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513902 COc1ccc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n2Cc2ccc(Cl)cc2)nn1 InChI=1S/C26H25ClN6O6/c1-26(2,22(34)35)15-33-24(36)29-23(32(25(33)37)14-16-4-6-17(27)7-5-16)28-18-8-10-19(11-9-18)39-21-13-12-20(38-3)30-31-21/h4-13H,14-15H2,1-3H3,(H,34,35)(H,28,29,36) LMXPTZDDFBNBKY-UHFFFAOYSA-N 271875 US10065941, Compound R-190::US9732060, Compound R-190 P2X purinoceptor 3 Homo sapiens 9.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271875 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271875&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295621 378153701 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513903 COc1ccc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n([C@@H](C)[C@@H](C)C(O)=O)c(=O)n2Cc2ccc(Cl)cc2)nn1 271876 US10065941, Compound R-191::US9732060, Compound R-191 P2X purinoceptor 3 Homo sapiens 12.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271876 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271876&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295624 378153702 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513904 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3nc4ccccc4s3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271877 US10065941, Compound R-192::US9732060, Compound R-192 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271877 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271877&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295626 378153703 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513905 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cncc(C)c3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C28H28ClN5O5/c1-18-13-23(15-30-14-18)39-22-11-9-21(10-12-22)31-25-32-26(36)34(17-28(2,3)24(35)38-4)27(37)33(25)16-19-5-7-20(29)8-6-19/h5-15H,16-17H2,1-4H3,(H,31,32,36) WKSOUTDTMVJOLB-UHFFFAOYSA-N 271878 US10065941, Compound R-193::US9732060, Compound R-193 P2X purinoceptor 3 Homo sapiens 11.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271878 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271878&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295625 378153704 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513906 Cc1cncc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n2Cc2ccc(Cl)cc2)c1 InChI=1S/C27H26ClN5O5/c1-17-12-22(14-29-13-17)38-21-10-8-20(9-11-21)30-24-31-25(36)33(16-27(2,3)23(34)35)26(37)32(24)15-18-4-6-19(28)7-5-18/h4-14H,15-16H2,1-3H3,(H,34,35)(H,30,31,36) INZKTCGPYXZVET-UHFFFAOYSA-N 271879 US10065941, Compound R-194::US9732060, Compound R-194 P2X purinoceptor 3 Homo sapiens 13.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271879 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271879&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295627 378153705 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513907 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ncns3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271880 US10065941, Compound R-195::US9732060, Compound R-195 P2X purinoceptor 3 Homo sapiens 9.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271880&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295628 378153706 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513908 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(F)nn3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271881 US10065941, Compound R-196::US9732060, Compound R-196 P2X purinoceptor 3 Homo sapiens 11.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271881 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271881&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295629 378153707 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513909 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(Cl)nn3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271882 US10065941, Compound R-197::US9732060, Compound R-197 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271882 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271882&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295630 378153708 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513910 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cc(F)ncn3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271883 US10065941, Compound R-198::US9732060, Compound R-198 P2X purinoceptor 3 Homo sapiens 9.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271883 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271883&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295631 378153709 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513911 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cncc(OC)c3)cc2)n(Cc2ccc(Cl)cc2)c1=O 271884 US10065941, Compound R-199::US9732060, Compound R-199 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271884 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271884&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295632 378153710 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513912 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cncc(OC)c3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C28H28ClN5O6/c1-28(2,24(35)39-4)17-34-26(36)32-25(33(27(34)37)16-18-5-7-19(29)8-6-18)31-20-9-11-21(12-10-20)40-23-13-22(38-3)14-30-15-23/h5-15H,16-17H2,1-4H3,(H,31,32,36) WYJTZZBVFCCLCK-UHFFFAOYSA-N 271885 US10065941, Compound R-200::US9732060, Compound R-200 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271885 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271885&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295633 378153711 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513913 COc1cncc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n2Cc2ccc(Cl)cc2)c1 271886 US10065941, Compound R-201::US9732060, Compound R-201 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271886 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271886&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295634 378153712 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513914 COc1cncc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n2Cc2ccc(Cl)cc2)c1 InChI=1S/C27H26ClN5O6/c1-27(2,23(34)35)16-33-25(36)31-24(32(26(33)37)15-17-4-6-18(28)7-5-17)30-19-8-10-20(11-9-19)39-22-12-21(38-3)13-29-14-22/h4-14H,15-16H2,1-3H3,(H,34,35)(H,30,31,36) OZLXGEWLOAZVPE-UHFFFAOYSA-N 271887 US10065941, Compound R-202::US9732060, Compound R-202 P2X purinoceptor 3 Homo sapiens 12.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271887 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271887&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295635 378153713 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513915 COC(=O)[C@H](C)[C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3cnc(cn3)C(N)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O 271888 US10065941, Compound R-203::US9732060, Compound R-203 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271888 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271888&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295636 378153714 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513916 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3nc4ncccc4o3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271889 US10065941, Compound R-204::US9732060, Compound R-204 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271889 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271889&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295637 378153715 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513917 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cccnc3)cc2)n(Cc2ccc(Cl)cc2)c1=O 271890 US10065941, Compound R-205::US9732060, Compound R-205 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271890 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271890&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295638 378153716 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513918 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccncc3)cc2)n(Cc2ccc(Cl)cc2)c1=O 271891 US10065941, Compound R-206::US9732060, Compound R-206 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271891 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271891&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295639 378153717 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513919 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cccnc3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271892 US10065941, Compound R-207::US9732060, Compound R-207 P2X purinoceptor 3 Homo sapiens 9.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271892 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271892&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295640 378153718 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513920 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccncc3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271893 US10065941, Compound R-208::US9732060, Compound R-208 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271893 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271893&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295641 378153719 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513921 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(C)nc3)cc2)n(Cc2ccc(C)cc2)c1=O 265599 US10065941, Compound R-209::US9718790, I-1209 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265599 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265599&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021081 377004472 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513922 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(C)nc3)cc2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 265665 US10065941, Compound R-210::US9718790, I-1232 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265665 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265665&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 130278497 377004537 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513923 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3nccnc3Cl)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271896 US10065941, Compound R-211::US9732060, Compound R-211 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271896 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271896&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295643 378153722 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513924 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3ccnc(c3)C#N)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271897 US10065941, Compound R-212::US9732060, Compound R-212 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271897 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271897&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295644 378153723 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513925 COC(=O)[C@H](C)[C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3ncc(C)s3)cc2)n(Cc2ccc(C)cc2)c1=O 271898 US10065941, Compound R-213::US9732060, Compound R-213 P2X purinoceptor 3 Homo sapiens 12.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271898 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271898&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752216 378153724 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513926 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ncc(C)s3)cc2)n(Cc2ccc(C)cc2)c1=O 271899 US10065941, Compound R-214::US9732060, Compound R-214 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271899 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271899&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752208 378153725 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513927 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ncc(C)s3)cc2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C27H29N5O5S/c1-17-6-8-19(9-7-17)15-31-23(30-24(34)32(26(31)35)16-27(3,4)22(33)36-5)29-20-10-12-21(13-11-20)37-25-28-14-18(2)38-25/h6-14H,15-16H2,1-5H3,(H,29,30,34) XDFBZWHMTGAIKP-UHFFFAOYSA-N 271900 US10065941, Compound R-215::US9732060, Compound R-215 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271900 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271900&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752204 378153726 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513928 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(OC(F)F)cn3)cc2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 271637 US10065941, Compound I-138::US10065941, Compound R-216::US9732060, Compound R-216 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271637 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271637&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752285 378153463 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513929 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3ncc(C)s3)cc2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 271902 US10065941, Compound R-217::US9732060, Compound R-217 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271902 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271902&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295646 378153727 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513930 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ncc(C)s3)cc2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 271903 US10065941, Compound R-218::US9732060, Compound R-218 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271903 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271903&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752370 378153728 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513931 Cc1cnc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n2Cc2ccc(C)cc2)s1 InChI=1S/C26H27N5O5S/c1-16-5-7-18(8-6-16)14-30-22(29-23(34)31(25(30)35)15-26(3,4)21(32)33)28-19-9-11-20(12-10-19)36-24-27-13-17(2)37-24/h5-13H,14-15H2,1-4H3,(H,32,33)(H,28,29,34) UJCKNJWAXXRDNS-UHFFFAOYSA-N 271904 US10065941, Compound R-219::US9732060, Compound R-219 P2X purinoceptor 3 Homo sapiens 11.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271904 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271904&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752390 378153729 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513932 CCc1oc2ccc(cc2c1C)\N=c1/[nH]c(=O)n(C[C@H](C)C(=O)OC)c(=O)n1Cc1ccc(C)cc1 271905 US10065941, Compound R-220::US9732060, Compound R-220 P2X purinoceptor 3 Homo sapiens 22.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271905 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271905&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752371 378153730 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513933 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccnc(F)c3)cc2)n(Cc2ccc(C)cc2)c1=O 271906 US10065941, Compound R-221::US9732060, Compound R-221 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271906 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271906&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752393 378153731 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513934 CCc1oc2ccc(cc2c1C)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(C)cc1 271907 US10065941, Compound R-222::US9732060, Compound R-222 P2X purinoceptor 3 Homo sapiens 9.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271907 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271907&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752394 378153732 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513935 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccnc(F)c3)cc2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 271908 US10065941, Compound R-223::US9732060, Compound R-223 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271908 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271908&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752384 378153733 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513936 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3cnc(cn3)C#N)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271909 US10065941, Compound R-224::US9732060, Compound R-224 P2X purinoceptor 3 Homo sapiens 12.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271909 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271909&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295648 378153734 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513937 COC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H22ClN5O5/c1-35-22(32)13-15-30-24(33)29-23(31(25(30)34)16-17-5-7-18(26)8-6-17)28-19-9-11-20(12-10-19)36-21-4-2-3-14-27-21/h2-12,14H,13,15-16H2,1H3,(H,28,29,33) AGHQUXOVNXUKMS-UHFFFAOYSA-N 271910 US10065941, Compound R-225::US9732060, Compound R-225 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271910 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271910&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295647 378153735 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513938 COC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C26H25N5O5/c1-18-6-8-19(9-7-18)17-31-24(29-25(33)30(26(31)34)16-14-23(32)35-2)28-20-10-12-21(13-11-20)36-22-5-3-4-15-27-22/h3-13,15H,14,16-17H2,1-2H3,(H,28,29,33) NRPWMDSRMHLJBB-UHFFFAOYSA-N 271911 US10065941, Compound R-226::US9732060, Compound R-226 P2X purinoceptor 3 Homo sapiens 3.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271911 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271911&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752341 378153736 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513939 COC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(cc2)-n2ccccc2=O)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H22ClN5O5/c1-36-22(33)13-15-30-24(34)28-23(31(25(30)35)16-17-5-7-18(26)8-6-17)27-19-9-11-20(12-10-19)29-14-3-2-4-21(29)32/h2-12,14H,13,15-16H2,1H3,(H,27,28,34) OXXYAGJVAQBRQC-UHFFFAOYSA-N 271912 US10065941, Compound R-227::US9732060, Compound R-227 P2X purinoceptor 3 Homo sapiens 35.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271912 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271912&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752336 378153737 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513940 NC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H21ClN6O4/c25-17-6-4-16(5-7-17)15-31-22(29-23(33)30(24(31)34)14-12-20(26)32)28-18-8-10-19(11-9-18)35-21-3-1-2-13-27-21/h1-11,13H,12,14-15H2,(H2,26,32)(H,28,29,33) UTHIDEBWLRUJBH-UHFFFAOYSA-N 271913 US10065941, Compound R-229::US9732060, Compound R-229 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271913 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271913&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295650 378153738 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513941 CNC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H23ClN6O4/c1-27-21(33)13-15-31-24(34)30-23(32(25(31)35)16-17-5-7-18(26)8-6-17)29-19-9-11-20(12-10-19)36-22-4-2-3-14-28-22/h2-12,14H,13,15-16H2,1H3,(H,27,33)(H,29,30,34) WNJRTUVEKILBQG-UHFFFAOYSA-N 271914 US10065941, Compound R-230::US9732060, Compound R-230 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271914 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271914&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295651 378153739 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513942 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc4nccn4n3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271915 US10065941, Compound R-231::US9732060, Compound R-231 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271915 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271915&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295652 378153740 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513943 COc1nc(=O)n(Cc2ccc(Cl)cc2)\c(=N\c2ccc(Oc3cccc(n3)C#N)cc2)[nH]1 InChI=1S/C23H17ClN6O3/c1-32-22-28-21(30(23(31)29-22)14-15-5-7-16(24)8-6-15)27-17-9-11-19(12-10-17)33-20-4-2-3-18(13-25)26-20/h2-12H,14H2,1H3,(H,27,28,29,31) DNWLHVYOCFEBTF-UHFFFAOYSA-N 271916 US10065941, Compound R-232::US9732060, Compound R-232 P2X purinoceptor 3 Homo sapiens 61.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271916 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271916&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 136213974 378153741 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513944 CC(C)(C)n1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(n3)C(N)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H25ClN6O4/c1-26(2,3)33-24(35)31-23(32(25(33)36)15-16-7-9-17(27)10-8-16)29-18-11-13-19(14-12-18)37-21-6-4-5-20(30-21)22(28)34/h4-14H,15H2,1-3H3,(H2,28,34)(H,29,31,35) PYPJFXASTVCJMD-UHFFFAOYSA-N 271917 US10065941, Compound R-233::US9732060, Compound R-233 P2X purinoceptor 3 Homo sapiens 318 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271917 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271917&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295654 378153742 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513945 CC1(C)OC[C@H](Cn2c(=O)[nH]\c(=N/c3ccc(Oc4ccccn4)cc3)n(Cc3ccc(Cl)cc3)c2=O)O1 271918 US10065941, Compound R-234::US9732060, Compound R-234 P2X purinoceptor 3 Homo sapiens 3.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271918 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271918&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295655 378153743 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513946 OC[C@@H](O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O 271919 US10065941, Compound R-235::US9732060, Compound R-235 P2X purinoceptor 3 Homo sapiens 10.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271919 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271919&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295656 378153744 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513947 CC1(C)OCC(C)(Cn2c(=O)[nH]\c(=N/c3ccc(Oc4ccccn4)cc3)n(Cc3ccc(Cl)cc3)c2=O)CO1 InChI=1S/C29H30ClN5O5/c1-28(2)38-18-29(3,19-39-28)17-35-26(36)33-25(34(27(35)37)16-20-7-9-21(30)10-8-20)32-22-11-13-23(14-12-22)40-24-6-4-5-15-31-24/h4-15H,16-19H2,1-3H3,(H,32,33,36) GOSGGPPJIMUUDR-UHFFFAOYSA-N 271920 US10065941, Compound R-236::US9732060, Compound R-236 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271920 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271920&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295657 378153745 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513948 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3nccnc3C)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271921 US10065941, Compound R-237::US9732060, Compound R-237 P2X purinoceptor 3 Homo sapiens 9.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271921 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271921&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295658 378153746 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513949 COC(=O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H20ClN5O5/c1-34-21(31)15-30-23(32)28-22(29(24(30)33)14-16-5-7-17(25)8-6-16)27-18-9-11-19(12-10-18)35-20-4-2-3-13-26-20/h2-13H,14-15H2,1H3,(H,27,28,32) NMKXGMIPEYCEOL-UHFFFAOYSA-N 271922 US10065941, Compound R-238::US9732060, Compound R-238 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271922 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271922&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752156 378153747 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513950 OC(=O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H18ClN5O5/c24-16-6-4-15(5-7-16)13-28-21(27-22(32)29(23(28)33)14-20(30)31)26-17-8-10-18(11-9-17)34-19-3-1-2-12-25-19/h1-12H,13-14H2,(H,30,31)(H,26,27,32) TXNDKVHGFNMHSL-UHFFFAOYSA-N 271923 US10065941, Compound R-239::US9732060, Compound R-239 P2X purinoceptor 3 Homo sapiens 399 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271923 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271923&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752177 378153748 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513951 NC(=O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H19ClN6O4/c24-16-6-4-15(5-7-16)13-29-21(28-22(32)30(23(29)33)14-19(25)31)27-17-8-10-18(11-9-17)34-20-3-1-2-12-26-20/h1-12H,13-14H2,(H2,25,31)(H,27,28,32) JXBOZMIMUSXUCX-UHFFFAOYSA-N 271924 US10065941, Compound R-240::US9732060, Compound R-240 P2X purinoceptor 3 Homo sapiens 11.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271924 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271924&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121280814 378153749 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513952 CNC(=O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H21ClN6O4/c1-26-20(32)15-31-23(33)29-22(30(24(31)34)14-16-5-7-17(25)8-6-16)28-18-9-11-19(12-10-18)35-21-4-2-3-13-27-21/h2-13H,14-15H2,1H3,(H,26,32)(H,28,29,33) JESKUQDYORHETP-UHFFFAOYSA-N 271925 US10065941, Compound R-241::US9732060, Compound R-241 P2X purinoceptor 3 Homo sapiens 9.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271925 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271925&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121296421 378153750 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513953 OCCNC(=O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H23ClN6O5/c26-18-6-4-17(5-7-18)15-31-23(30-24(35)32(25(31)36)16-21(34)27-13-14-33)29-19-8-10-20(11-9-19)37-22-3-1-2-12-28-22/h1-12,33H,13-16H2,(H,27,34)(H,29,30,35) UCNSAORDZKTNGO-UHFFFAOYSA-N 271926 US10065941, Compound R-242::US9732060, Compound R-242 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271926 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271926&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121296423 378153751 C04080 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513954 FC(F)(F)CNC(=O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H20ClF3N6O4/c26-17-6-4-16(5-7-17)13-34-22(32-18-8-10-19(11-9-18)39-21-3-1-2-12-30-21)33-23(37)35(24(34)38)14-20(36)31-15-25(27,28)29/h1-12H,13-15H2,(H,31,36)(H,32,33,37) RXYNFALWOGFABI-UHFFFAOYSA-N 271927 US10065941, Compound R-243::US9732060, Compound R-243 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271927 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271927&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121296415 378153752 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513955 CC(CO)(CO)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H26ClN5O5/c1-26(16-33,17-34)15-32-24(35)30-23(31(25(32)36)14-18-5-7-19(27)8-6-18)29-20-9-11-21(12-10-20)37-22-4-2-3-13-28-22/h2-13,33-34H,14-17H2,1H3,(H,29,30,35) HFXSNXQMXQZJOF-UHFFFAOYSA-N 271928 US10065941, Compound R-244::US9732060, Compound R-244 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271928 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271928&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295659 378153753 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513956 CC1(C)OCC(Cn2c(=O)[nH]\c(=N/c3ccc(Oc4ccccn4)cc3)n(Cc3ccc(Cl)cc3)c2=O)CO1 InChI=1S/C28H28ClN5O5/c1-28(2)37-17-20(18-38-28)16-34-26(35)32-25(33(27(34)36)15-19-6-8-21(29)9-7-19)31-22-10-12-23(13-11-22)39-24-5-3-4-14-30-24/h3-14,20H,15-18H2,1-2H3,(H,31,32,35) RTXQHZGMWZFXHO-UHFFFAOYSA-N 271929 US10065941, Compound R-245::US9732060, Compound R-245 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271929 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271929&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295660 378153754 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513957 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cnc(nc3)C#N)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271930 US10065941, Compound R-246::US9732060, Compound R-246 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271930 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271930&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295661 378153755 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513958 CC1(C)OC[C@@H](Cn2c(=O)[nH]\c(=N/c3ccc(Oc4ccccn4)cc3)n(Cc3ccc(Cl)cc3)c2=O)O1 271931 US10065941, Compound R-247::US9732060, Compound R-247 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271931 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271931&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295662 378153756 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513959 Clc1ccc(Cn2c(=O)n(CCCOC3CCCCO3)c(=O)[nH]\c2=N/c2ccc(Oc3ccccn3)cc2)cc1 271932 US10065941, Compound R-248::US9732060, Compound R-248 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271932 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271932&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752157 378153757 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513960 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3cnc(nc3)C#N)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271933 US10065941, Compound R-249::US9732060, Compound R-249 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271933 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271933&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295663 378153758 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513961 OC[C@H](O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O 271934 US10065941, Compound R-250::US9732060, Compound R-250 P2X purinoceptor 3 Homo sapiens 9.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271934 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271934&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295664 378153759 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513962 OCCCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H22ClN5O4/c25-18-7-5-17(6-8-18)16-30-22(28-23(32)29(24(30)33)14-3-15-31)27-19-9-11-20(12-10-19)34-21-4-1-2-13-26-21/h1-2,4-13,31H,3,14-16H2,(H,27,28,32) KPGHPKPTWFHFPE-UHFFFAOYSA-N 271935 US10065941, Compound R-251::US9732060, Compound R-251 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271935 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271935&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752158 378153760 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513963 OCC(=C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H22ClN5O4/c1-17(16-32)14-31-24(33)29-23(30(25(31)34)15-18-5-7-19(26)8-6-18)28-20-9-11-21(12-10-20)35-22-4-2-3-13-27-22/h2-13,32H,1,14-16H2,(H,28,29,33) NAWNIYPIOZDJMJ-UHFFFAOYSA-N 271936 US10065941, Compound R-254::US9732060, Compound R-254 P2X purinoceptor 3 Homo sapiens 3.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271936 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271936&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752164 378153761 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513964 OCC(O)(CO)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H24ClN5O6/c26-18-6-4-17(5-7-18)13-30-22(29-23(34)31(24(30)35)14-25(36,15-32)16-33)28-19-8-10-20(11-9-19)37-21-3-1-2-12-27-21/h1-12,32-33,36H,13-16H2,(H,28,29,34) GACPIASDRFHZSF-UHFFFAOYSA-N 271937 US10065941, Compound R-255::US9732060, Compound R-255 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271937 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271937&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121280858 378153762 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513965 NC(=O)NC(=O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H20ClN7O5/c25-16-6-4-15(5-7-16)13-31-22(30-23(35)32(24(31)36)14-19(33)29-21(26)34)28-17-8-10-18(11-9-17)37-20-3-1-2-12-27-20/h1-12H,13-14H2,(H,28,30,35)(H3,26,29,33,34) HRZSXWMCUMJBGW-UHFFFAOYSA-N 271938 US10065941, Compound R-256::US9732060, Compound R-256 P2X purinoceptor 3 Homo sapiens 2.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271938 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271938&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121296425 378153763 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513966 OCCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H20ClN5O4/c24-17-6-4-16(5-7-17)15-29-21(27-22(31)28(13-14-30)23(29)32)26-18-8-10-19(11-9-18)33-20-3-1-2-12-25-20/h1-12,30H,13-15H2,(H,26,27,31) RQIVBOOYYUQQPU-UHFFFAOYSA-N 271939 US10065941, Compound R-257::US9732060, Compound R-257 P2X purinoceptor 3 Homo sapiens 10.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271939 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271939&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752310 378153764 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513967 CO[C@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271940 US10065941, Compound I-200::US9732060, Compound I-200 P2X purinoceptor 3 Homo sapiens 42.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271940 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271940&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752364 378153765 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513968 OC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(F)n3)cc2)n(Cc2ccc(CF)cc2)c1=O InChI=1S/C25H21F2N5O5/c26-14-16-4-6-17(7-5-16)15-32-23(30-24(35)31(25(32)36)13-12-22(33)34)28-18-8-10-19(11-9-18)37-21-3-1-2-20(27)29-21/h1-11H,12-15H2,(H,33,34)(H,28,30,35) WIFQGDFHLPPRIU-UHFFFAOYSA-N 271941 US10065941, Compound R-275::US9732060, Compound R-275 P2X purinoceptor 3 Homo sapiens 23.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271941 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271941&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752247 378153766 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513969 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(Cc2ccc(cc2)C(F)F)c1=O)C(O)=O 271942 US10065941, Compound I-201::US9732060, Compound I-201 P2X purinoceptor 3 Homo sapiens 13.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271942 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271942&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752365 378153767 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513970 OC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ncccc3F)cc2)n(Cc2ccc(CF)cc2)c1=O InChI=1S/C25H21F2N5O5/c26-14-16-3-5-17(6-4-16)15-32-23(30-24(35)31(25(32)36)13-11-21(33)34)29-18-7-9-19(10-8-18)37-22-20(27)2-1-12-28-22/h1-10,12H,11,13-15H2,(H,33,34)(H,29,30,35) BDGQPLXXZCOIBY-UHFFFAOYSA-N 271943 US10065941, Compound R-276::US9732060, Compound R-276 P2X purinoceptor 3 Homo sapiens 42.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271943 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271943&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752244 378153768 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513971 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(CC2CCC3(CC3)CC2)c1=O)C(O)=O 271944 US10065941, Compound I-202::US9732060, Compound I-202 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271944 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271944&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752379 378153769 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513972 Cc1ccc(Cn2c(=O)n(CCCC(O)=O)c(=O)[nH]\c2=N/c2ccc(Oc3ncccc3F)cc2)cc1 InChI=1S/C26H24FN5O5/c1-17-6-8-18(9-7-17)16-32-24(30-25(35)31(26(32)36)15-3-5-22(33)34)29-19-10-12-20(13-11-19)37-23-21(27)4-2-14-28-23/h2,4,6-14H,3,5,15-16H2,1H3,(H,33,34)(H,29,30,35) ATBCVSIBQDISOQ-UHFFFAOYSA-N 271945 US10065941, Compound R-277::US9732060, Compound R-277 P2X purinoceptor 3 Homo sapiens 14.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271945 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271945&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752245 378153770 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513973 CO[C@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(=O)OC 271946 US10065941, Compound I-203::US9732060, Compound I-203 P2X purinoceptor 3 Homo sapiens 3.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271946 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271946&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752356 378153771 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513974 Cc1ccc(Cn2c(=O)n(CCCC(O)=O)c(=O)[nH]\c2=N/c2ccc(Oc3ccc(F)cn3)cc2)cc1 InChI=1S/C26H24FN5O5/c1-17-4-6-18(7-5-17)16-32-24(30-25(35)31(26(32)36)14-2-3-23(33)34)29-20-9-11-21(12-10-20)37-22-13-8-19(27)15-28-22/h4-13,15H,2-3,14,16H2,1H3,(H,33,34)(H,29,30,35) SLZIAROFBLAYBQ-UHFFFAOYSA-N 271947 US10065941, Compound R-278::US9732060, Compound R-278 P2X purinoceptor 3 Homo sapiens 15.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271947 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271947&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752248 378153772 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513975 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)c(F)c2)n(Cc2ccc(C)cc2)c1=O 271948 US10065941, Compound I-204::US10065941, Compound I-253::US9732060, Compound I-204 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271948 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271948&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752354 378153773 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513976 Cc1ccc(Cn2c(=O)n(CCCC(O)=O)c(=O)[nH]\c2=N/c2ccc(Oc3cccc(F)n3)cc2)cc1 InChI=1S/C26H24FN5O5/c1-17-7-9-18(10-8-17)16-32-24(30-25(35)31(26(32)36)15-3-6-23(33)34)28-19-11-13-20(14-12-19)37-22-5-2-4-21(27)29-22/h2,4-5,7-14H,3,6,15-16H2,1H3,(H,33,34)(H,28,30,35) HERSQUYGRISQKR-UHFFFAOYSA-N 271949 US10065941, Compound R-279::US9732060, Compound R-279 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271949 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271949&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752246 378153774 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513977 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O 271950 US10065941, Compound I-205::US9732060, Compound I-205 P2X purinoceptor 3 Homo sapiens 12.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271950 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271950&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752115 378153775 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513978 Cc1ccc(Cn2c(=O)n(CCC(O)=O)c(=O)[nH]\c2=N/c2ccc(Oc3ccccn3)c(F)c2)cc1 InChI=1S/C25H22FN5O5/c1-16-5-7-17(8-6-16)15-31-23(29-24(34)30(25(31)35)13-11-22(32)33)28-18-9-10-20(19(26)14-18)36-21-4-2-3-12-27-21/h2-10,12,14H,11,13,15H2,1H3,(H,32,33)(H,28,29,34) HZQRMWFVLQSWSX-UHFFFAOYSA-N 271951 US10065941, Compound R-280::US9732060, Compound R-280 P2X purinoceptor 3 Homo sapiens 9.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271951 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271951&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295671 378153776 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513979 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(Cc2ccc(CF)cc2)c1=O 271952 US10065941, Compound I-206::US9732060, Compound I-206 P2X purinoceptor 3 Homo sapiens 10.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271952 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271952&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295436 378153777 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513980 OC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H19ClFN5O5/c25-16-6-4-15(5-7-16)14-31-22(29-23(34)30(24(31)35)12-10-21(32)33)28-17-8-9-19(18(26)13-17)36-20-3-1-2-11-27-20/h1-9,11,13H,10,12,14H2,(H,32,33)(H,28,29,34) MAHIPYQAKQUSJL-UHFFFAOYSA-N 271953 US10065941, Compound R-281::US9732060, Compound R-281 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271953 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271953&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752346 378153778 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513981 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ncccc3F)cc2)n(Cc2ccc(CF)cc2)c1=O 271954 US10065941, Compound I-207::US9732060, Compound I-207 P2X purinoceptor 3 Homo sapiens 12.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271954 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271954&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752116 378153779 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513982 Cc1ccc(Cn2c(=O)n(CCC(O)=O)c(=O)[nH]\c2=N/c2ccc(Oc3ccccn3)c(C)c2)cc1 InChI=1S/C26H25N5O5/c1-17-6-8-19(9-7-17)16-31-24(29-25(34)30(26(31)35)14-12-23(32)33)28-20-10-11-21(18(2)15-20)36-22-5-3-4-13-27-22/h3-11,13,15H,12,14,16H2,1-2H3,(H,32,33)(H,28,29,34) KWYDOWGTSATFLE-UHFFFAOYSA-N 271955 US10065941, Compound R-282::US9732060, Compound R-282 P2X purinoceptor 3 Homo sapiens 23.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271955 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271955&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752343 378153780 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513983 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(F)cn3)cc2)n(Cc2ccc(CF)cc2)c1=O 271956 US10065941, Compound I-208::US9732060, Compound I-208 P2X purinoceptor 3 Homo sapiens 12.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271956 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271956&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752117 378153781 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513984 Cc1cc(ccc1Oc1ccccn1)\N=c1/[nH]c(=O)n(CCC(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C25H22ClN5O5/c1-16-14-19(9-10-20(16)36-21-4-2-3-12-27-21)28-23-29-24(34)30(13-11-22(32)33)25(35)31(23)15-17-5-7-18(26)8-6-17/h2-10,12,14H,11,13,15H2,1H3,(H,32,33)(H,28,29,34) ZMIMMGQVQOGJTM-UHFFFAOYSA-N 271957 US10065941, Compound R-283::US9732060, Compound R-283 P2X purinoceptor 3 Homo sapiens 28.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271957 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271957&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752347 378153782 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513985 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(F)n3)cc2)n(Cc2ccc(CF)cc2)c1=O 271958 US10065941, Compound I-209::US9732060, Compound I-209 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271958 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271958&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752133 378153783 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513986 OC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(Cl)cn3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H19Cl2N5O5/c25-16-3-1-15(2-4-16)14-31-22(29-23(34)30(24(31)35)12-11-21(32)33)28-18-6-8-19(9-7-18)36-20-10-5-17(26)13-27-20/h1-10,13H,11-12,14H2,(H,32,33)(H,28,29,34) CGRNXHZLJUICRL-UHFFFAOYSA-N 271959 US10065941, Compound R-284::US9732060, Compound R-284 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271959 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271959&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752344 378153784 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513987 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)c(F)c2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 271960 US10065941, Compound I-210::US9732060, Compound I-210 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271960 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271960&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295439 378153785 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513988 Cc1ccc(Cn2c(=O)n(CCC(O)=O)c(=O)[nH]\c2=N/c2ccc(Oc3ccc(Cl)cn3)cc2)cc1 InChI=1S/C25H22ClN5O5/c1-16-2-4-17(5-3-16)15-31-23(29-24(34)30(25(31)35)13-12-22(32)33)28-19-7-9-20(10-8-19)36-21-11-6-18(26)14-27-21/h2-11,14H,12-13,15H2,1H3,(H,32,33)(H,28,29,34) XQAHSJCLMAGHPK-UHFFFAOYSA-N 271961 US10065941, Compound R-285::US9732060, Compound R-285 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271961 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271961&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752259 378153786 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513989 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271962 US10065941, Compound I-211::US9732060, Compound I-211 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271962 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271962&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752241 378153787 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513990 COC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(F)n3)cc2)n(Cc2ccc(CF)cc2)c1=O InChI=1S/C26H23F2N5O5/c1-37-23(34)13-14-32-25(35)31-24(33(26(32)36)16-18-7-5-17(15-27)6-8-18)29-19-9-11-20(12-10-19)38-22-4-2-3-21(28)30-22/h2-12H,13-16H2,1H3,(H,29,31,35) QQWISUYCHJNOFS-UHFFFAOYSA-N 271963 US10065941, Compound R-286::US9732060, Compound R-286 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271963 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271963&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752281 378153788 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513991 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271964 US10065941, Compound I-212::US9732060, Compound I-212 P2X purinoceptor 3 Homo sapiens 10.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271964 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271964&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752207 378153789 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513992 COC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(Cl)cn3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H21Cl2N5O5/c1-36-22(33)12-13-31-24(34)30-23(32(25(31)35)15-16-2-4-17(26)5-3-16)29-19-7-9-20(10-8-19)37-21-11-6-18(27)14-28-21/h2-11,14H,12-13,15H2,1H3,(H,29,30,34) KPOFBJFBAQLXMI-UHFFFAOYSA-N 271965 US10065941, Compound R-287::US9732060, Compound R-287 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271965 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271965&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295672 378153790 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513993 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)c(C)c2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 271966 US10065941, Compound I-213::US9732060, Compound I-213 P2X purinoceptor 3 Homo sapiens 12.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271966 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271966&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295437 378153791 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513994 COC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ncccc3F)cc2)n(Cc2ccc(CF)cc2)c1=O InChI=1S/C26H23F2N5O5/c1-37-22(34)12-14-32-25(35)31-24(33(26(32)36)16-18-6-4-17(15-27)5-7-18)30-19-8-10-20(11-9-19)38-23-21(28)3-2-13-29-23/h2-11,13H,12,14-16H2,1H3,(H,30,31,35) YHVSDTMNCPWGTM-UHFFFAOYSA-N 271967 US10065941, Compound R-288::US9732060, Compound R-288 P2X purinoceptor 3 Homo sapiens 12.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271967 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271967&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752265 378153792 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513995 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(Cc2ccc(CF)cc2)c1=O)C(O)=O 271968 US10065941, Compound I-214::US9732060, Compound I-214 P2X purinoceptor 3 Homo sapiens 11.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271968 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271968&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752226 378153793 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513996 COC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(Cl)cn3)cc2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C26H24ClN5O5/c1-17-3-5-18(6-4-17)16-32-24(30-25(34)31(26(32)35)14-13-23(33)36-2)29-20-8-10-21(11-9-20)37-22-12-7-19(27)15-28-22/h3-12,15H,13-14,16H2,1-2H3,(H,29,30,34) KQMYLQNUSDISOI-UHFFFAOYSA-N 271969 US10065941, Compound R-289::US9732060, Compound R-289 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271969 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271969&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752260 378153794 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513997 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ncccc3F)cc2)n(Cc2ccc(CF)cc2)c1=O)C(O)=O 271970 US10065941, Compound I-215::US9732060, Compound I-215 P2X purinoceptor 3 Homo sapiens 16.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271970 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271970&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752373 378153795 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513998 COC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)c(C)c2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C27H27N5O5/c1-18-7-9-20(10-8-18)17-32-25(30-26(34)31(27(32)35)15-13-24(33)36-3)29-21-11-12-22(19(2)16-21)37-23-6-4-5-14-28-23/h4-12,14,16H,13,15,17H2,1-3H3,(H,29,30,34) MDLDKRZRQMPQJH-UHFFFAOYSA-N 271971 US10065941, Compound R-290::US9732060, Compound R-290 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271971 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271971&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752391 378153796 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 513999 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(F)cn3)cc2)n(Cc2ccc(CF)cc2)c1=O)C(O)=O 271972 US10065941, Compound I-216::US9732060, Compound I-216 P2X purinoceptor 3 Homo sapiens 17.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271972 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271972&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752374 378153797 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 514000 COC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H24ClN5O5/c1-17-15-20(10-11-21(17)37-22-5-3-4-13-28-22)29-24-30-25(34)31(14-12-23(33)36-2)26(35)32(24)16-18-6-8-19(27)9-7-18/h3-11,13,15H,12,14,16H2,1-2H3,(H,29,30,34) BQEVANLSYANDHH-UHFFFAOYSA-N 271973 US10065941, Compound R-291::US9732060, Compound R-291 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271973 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271973&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752389 378153798 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 514001 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(F)n3)cc2)n(Cc2ccc(CF)cc2)c1=O)C(O)=O 271974 US10065941, Compound I-217::US9732060, Compound I-217 P2X purinoceptor 3 Homo sapiens 11.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271974 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271974&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752361 378153799 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 514002 COC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)c(F)c2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C26H24FN5O5/c1-17-6-8-18(9-7-17)16-32-24(30-25(34)31(26(32)35)14-12-23(33)36-2)29-19-10-11-21(20(27)15-19)37-22-5-3-4-13-28-22/h3-11,13,15H,12,14,16H2,1-2H3,(H,29,30,34) YTCBWVPNRZSTOA-UHFFFAOYSA-N 271975 US10065941, Compound R-292::US9732060, Compound R-292 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271975 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271975&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295673 378153800 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 514003 COc1cccc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n2Cc2ccc(C)cc2)n1 271976 US10065941, Compound I-218::US9732060, Compound I-218 P2X purinoceptor 3 Homo sapiens 10.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271976 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271976&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295438 378153801 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 514004 COC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H21ClFN5O5/c1-36-22(33)11-13-31-24(34)30-23(32(25(31)35)15-16-5-7-17(26)8-6-16)29-18-9-10-20(19(27)14-18)37-21-4-2-3-12-28-21/h2-10,12,14H,11,13,15H2,1H3,(H,29,30,34) BPMLFIMUNBQLTG-UHFFFAOYSA-N 271977 US10065941, Compound R-293::US9732060, Compound R-293 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271977 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271977&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752385 378153802 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 514005 Cc1cc(ccc1Oc1ccccn1)\N=c1/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C27H26ClN5O5/c1-17-14-20(11-12-21(17)38-22-6-4-5-13-29-22)30-24-31-25(36)33(16-27(2,3)23(34)35)26(37)32(24)15-18-7-9-19(28)10-8-18/h4-14H,15-16H2,1-3H3,(H,34,35)(H,30,31,36) UEISQYYFQGQLOA-UHFFFAOYSA-N 271978 US10065941, Compound I-219::US9732060, Compound I-219 P2X purinoceptor 3 Homo sapiens 12.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271978 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271978&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752362 378153803 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 514006 CCOC(=O)CCCn1c(=O)[nH]\c(=N/c2ccc(Oc3ncccc3F)cc2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C28H28FN5O5/c1-3-38-24(35)7-5-17-33-27(36)32-26(34(28(33)37)18-20-10-8-19(2)9-11-20)31-21-12-14-22(15-13-21)39-25-23(29)6-4-16-30-25/h4,6,8-16H,3,5,7,17-18H2,1-2H3,(H,31,32,36) ZHNWXPKKVRRVCI-UHFFFAOYSA-N 271979 US10065941, Compound R-294::US9732060, Compound R-294 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271979 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271979&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752386 378153804 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 514007 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271980 US10065941, Compound I-220::US9732060, Compound I-220 P2X purinoceptor 3 Homo sapiens 10.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271980 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271980&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752120 378153805 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 514008 CCOC(=O)CCCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(F)cn3)cc2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C28H28FN5O5/c1-3-38-25(35)5-4-16-33-27(36)32-26(34(28(33)37)18-20-8-6-19(2)7-9-20)31-22-11-13-23(14-12-22)39-24-15-10-21(29)17-30-24/h6-15,17H,3-5,16,18H2,1-2H3,(H,31,32,36) CCHTUSFFNQDRJH-UHFFFAOYSA-N 271981 US10065941, Compound R-295::US9732060, Compound R-295 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271981 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271981&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752382 378153806 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 514009 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(OC)n3)cc2)n(Cc2ccc(C)cc2)c1=O 271982 US10065941, Compound I-221::US9732060, Compound I-221 P2X purinoceptor 3 Homo sapiens 11.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271982 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271982&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752118 378153807 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 514010 CCOC(=O)CCCn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(F)n3)cc2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C28H28FN5O5/c1-3-38-25(35)8-5-17-33-27(36)32-26(34(28(33)37)18-20-11-9-19(2)10-12-20)30-21-13-15-22(16-14-21)39-24-7-4-6-23(29)31-24/h4,6-7,9-16H,3,5,8,17-18H2,1-2H3,(H,30,32,36) BITSFVQWUCICOI-UHFFFAOYSA-N 271983 US10065941, Compound R-296::US9732060, Compound R-296 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271983 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271983&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752372 378153808 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 514011 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(OC)cn3)cc2)n(Cc2ccc(C)cc2)c1=O 271984 US10065941, Compound I-222::US9732060, Compound I-222 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271984 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271984&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752119 378153809 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 514012 OC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)c(Cl)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H19Cl2N5O5/c25-16-6-4-15(5-7-16)14-31-22(29-23(34)30(24(31)35)12-10-21(32)33)28-17-8-9-19(18(26)13-17)36-20-3-1-2-11-27-20/h1-9,11,13H,10,12,14H2,(H,32,33)(H,28,29,34) FFFVHDAXDQUDQG-UHFFFAOYSA-N 271985 US10065941, Compound R-297::US9732060, Compound R-297 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271985 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271985&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752387 378153810 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 514013 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O 271986 US10065941, Compound I-223::US9732060, Compound I-223 P2X purinoceptor 3 Homo sapiens 11.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271986 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271986&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752129 378153811 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 514014 Cc1ccc(Cn2c(=O)n(CCC(O)=O)c(=O)[nH]\c2=N/c2ccc(Oc3ccccn3)c(Cl)c2)cc1 InChI=1S/C25H22ClN5O5/c1-16-5-7-17(8-6-16)15-31-23(29-24(34)30(25(31)35)13-11-22(32)33)28-18-9-10-20(19(26)14-18)36-21-4-2-3-12-27-21/h2-10,12,14H,11,13,15H2,1H3,(H,32,33)(H,28,29,34) JICVDYHZXWIKQZ-UHFFFAOYSA-N 271987 US10065941, Compound R-298::US9732060, Compound R-298 P2X purinoceptor 3 Homo sapiens 9.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271987 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271987&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752383 378153812 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 514015 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)c(C)c2)n(Cc2ccc(C)cc2)c1=O 271988 US10065941, Compound I-224::US9732060, Compound I-224 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271988 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271988&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752121 378153813 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 514016 CC(=O)c1cccc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(CCC(O)=O)c(=O)n2Cc2ccc(Cl)cc2)n1 InChI=1S/C26H22ClN5O6/c1-16(33)21-3-2-4-22(29-21)38-20-11-9-19(10-12-20)28-24-30-25(36)31(14-13-23(34)35)26(37)32(24)15-17-5-7-18(27)8-6-17/h2-12H,13-15H2,1H3,(H,34,35)(H,28,30,36) GLOLUYQIMMOKHN-UHFFFAOYSA-N 271989 US10065941, Compound R-299::US9732060, Compound R-299 P2X purinoceptor 3 Homo sapiens 20.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271989 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271989&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752170 378153814 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 514017 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C28H28ClN5O5/c1-18-15-21(12-13-22(18)39-23-7-5-6-14-30-23)31-25-32-26(36)34(17-28(2,3)24(35)38-4)27(37)33(25)16-19-8-10-20(29)11-9-19/h5-15H,16-17H2,1-4H3,(H,31,32,36) BFZGLKHEKBTCIN-UHFFFAOYSA-N 271990 US10065941, Compound I-225::US9732060, Compound I-225 P2X purinoceptor 3 Homo sapiens 14.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271990 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271990&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752193 378153815 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 514018 COC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)c(Cl)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H21Cl2N5O5/c1-36-22(33)11-13-31-24(34)30-23(32(25(31)35)15-16-5-7-17(26)8-6-16)29-18-9-10-20(19(27)14-18)37-21-4-2-3-12-28-21/h2-10,12,14H,11,13,15H2,1H3,(H,29,30,34) QRNIHVKXQPIHIP-UHFFFAOYSA-N 271991 US10065941, Compound R-300::US9732060, Compound R-300 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271991 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271991&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752189 378153816 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 514019 COC(=O)[C@H](C)[C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O 271992 US10065941, Compound I-226::US9732060, Compound I-226 P2X purinoceptor 3 Homo sapiens 38.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271992 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271992&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752238 378153817 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 514020 COC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)c(Cl)c2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C26H24ClN5O5/c1-17-6-8-18(9-7-17)16-32-24(30-25(34)31(26(32)35)14-12-23(33)36-2)29-19-10-11-21(20(27)15-19)37-22-5-3-4-13-28-22/h3-11,13,15H,12,14,16H2,1-2H3,(H,29,30,34) VSMAJCFXSMVGMC-UHFFFAOYSA-N 271993 US10065941, Compound R-301::US9732060, Compound R-301 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271993 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271993&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752222 378153818 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 514021 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C27H25ClFN5O5/c1-27(2,23(35)38-3)16-34-25(36)32-24(33(26(34)37)15-17-7-9-18(28)10-8-17)31-19-11-12-21(20(29)14-19)39-22-6-4-5-13-30-22/h4-14H,15-16H2,1-3H3,(H,31,32,36) ABPXHJZMOOCTEP-UHFFFAOYSA-N 271994 US10065941, Compound I-227::US9732060, Compound I-227 P2X purinoceptor 3 Homo sapiens 31.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271994 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271994&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752176 378153819 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 514022 COC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(n3)C(C)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C27H24ClN5O6/c1-17(34)22-4-3-5-23(30-22)39-21-12-10-20(11-13-21)29-25-31-26(36)32(15-14-24(35)38-2)27(37)33(25)16-18-6-8-19(28)9-7-18/h3-13H,14-16H2,1-2H3,(H,29,31,36) QJXQUDLXIKYZBY-UHFFFAOYSA-N 271995 US10065941, Compound R-302::US9732060, Compound R-302 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271995 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271995&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295674 378153820 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 514023 COC(=O)[C@H](C)[C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O 271996 US10065941, Compound I-228::US9732060, Compound I-228 P2X purinoceptor 3 Homo sapiens 21.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271996 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271996&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295440 378153821 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 514024 COC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(cn3)C(C)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C27H24ClN5O6/c1-17(34)19-5-12-23(29-15-19)39-22-10-8-21(9-11-22)30-25-31-26(36)32(14-13-24(35)38-2)27(37)33(25)16-18-3-6-20(28)7-4-18/h3-12,15H,13-14,16H2,1-2H3,(H,30,31,36) ZPUADLGXCXLGEQ-UHFFFAOYSA-N 271997 US10065941, Compound R-303::US9732060, Compound R-303 P2X purinoceptor 3 Homo sapiens 3.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271997 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271997&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295675 378153822 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 514025 COc1ccc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n2Cc2ccc(C)cc2)nc1 271998 US10065941, Compound I-229::US9732060, Compound I-229 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271998 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271998&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295441 378153823 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 514026 COC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(cn3)C(C)O)cc2)n(Cc2ccc(Cl)cc2)c1=O 271999 US10065941, Compound R-304::US9732060, Compound R-304 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271999 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271999&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295676 378153824 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 514027 CC(C)(Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O InChI=1S/C26H23ClFN5O5/c1-26(2,22(34)35)15-33-24(36)31-23(32(25(33)37)14-16-6-8-17(27)9-7-16)30-18-10-11-20(19(28)13-18)38-21-5-3-4-12-29-21/h3-13H,14-15H2,1-2H3,(H,34,35)(H,30,31,36) GQGUDZAMEOXEAU-UHFFFAOYSA-N 272000 US10065941, Compound I-230::US9732060, Compound I-230 P2X purinoceptor 3 Homo sapiens 11.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272000 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272000&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752173 378153825 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 514028 CC(=O)c1ccc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(CCC(O)=O)c(=O)n2Cc2ccc(Cl)cc2)nc1 InChI=1S/C26H22ClN5O6/c1-16(33)18-4-11-22(28-14-18)38-21-9-7-20(8-10-21)29-24-30-25(36)31(13-12-23(34)35)26(37)32(24)15-17-2-5-19(27)6-3-17/h2-11,14H,12-13,15H2,1H3,(H,34,35)(H,29,30,36) XAJWCIYYMGKVSC-UHFFFAOYSA-N 272001 US10065941, Compound R-305::US9732060, Compound R-305 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272001 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272001&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295677 378153826 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 514029 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 272002 US10065941, Compound I-231::US9732060, Compound I-231 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272002 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272002&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752199 378153827 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 514030 CC(O)c1ccc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(CCC(O)=O)c(=O)n2Cc2ccc(Cl)cc2)nc1 272003 US10065941, Compound R-306::US9732060, Compound R-306 P2X purinoceptor 3 Homo sapiens 14.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272003 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272003&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295678 378153828 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 514031 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(CF)cn3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 272004 US10065941, Compound I-232::US9732060, Compound I-232 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272004 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272004&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295442 378153829 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 514032 CCOC(=O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(Cc2ccc(F)cc2)c1=O InChI=1S/C25H22FN5O5/c1-2-35-22(32)16-31-24(33)29-23(30(25(31)34)15-17-6-8-18(26)9-7-17)28-19-10-12-20(13-11-19)36-21-5-3-4-14-27-21/h3-14H,2,15-16H2,1H3,(H,28,29,33) FTHOQGWSLSKJCX-UHFFFAOYSA-N 272005 US10065941, Compound R-307::US9732060, Compound R-307 P2X purinoceptor 3 Homo sapiens 13.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272005 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272005&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752302 378153830 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 514033 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(CF)nc3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 272006 US10065941, Compound I-233::US9732060, Compound I-233 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272006 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272006&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295443 378153831 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 514034 CCOC(=O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(F)cn3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H21ClFN5O5/c1-2-36-22(33)15-32-24(34)30-23(31(25(32)35)14-16-3-5-17(26)6-4-16)29-19-8-10-20(11-9-19)37-21-12-7-18(27)13-28-21/h3-13H,2,14-15H2,1H3,(H,29,30,34) LZXTWYDQLCXYBJ-UHFFFAOYSA-N 272007 US10065941, Compound R-309::US9732060, Compound R-309 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272007 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272007&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295679 378153832 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 514035 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(F)n3)cc2)n(CC2CCC3(CC3)CC2)c1=O)C(O)=O 272008 US10065941, Compound I-234::US9732060, Compound I-234 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272008 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272008&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752229 378153833 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 514036 CCOC(=O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(Cl)cn3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H21Cl2N5O5/c1-2-36-22(33)15-32-24(34)30-23(31(25(32)35)14-16-3-5-17(26)6-4-16)29-19-8-10-20(11-9-19)37-21-12-7-18(27)13-28-21/h3-13H,2,14-15H2,1H3,(H,29,30,34) IDHUNPPWIBAJJY-UHFFFAOYSA-N 272009 US10065941, Compound R-310::US9732060, Compound R-310 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272009 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272009&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295682 378153834 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 514037 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(F)cn3)cc2)n(CC2CCC3(CC3)CC2)c1=O)C(O)=O 272010 US10065941, Compound I-235::US9732060, Compound I-235 P2X purinoceptor 3 Homo sapiens 9.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272010 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272010&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752236 378153835 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 514038 OC(=O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(F)cn3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H17ClFN5O5/c24-15-3-1-14(2-4-15)12-29-21(28-22(33)30(23(29)34)13-20(31)32)27-17-6-8-18(9-7-17)35-19-10-5-16(25)11-26-19/h1-11H,12-13H2,(H,31,32)(H,27,28,33) GRSFGWFDUAJOLJ-UHFFFAOYSA-N 272011 US10065941, Compound R-311::US9732060, Compound R-311 P2X purinoceptor 3 Homo sapiens 428 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272011 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272011&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752251 378153836 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 514039 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(F)n3)cc2)n(CC2CCC3(CC3)CC2)c1=O 272012 US10065941, Compound I-236::US9732060, Compound I-236 P2X purinoceptor 3 Homo sapiens 16.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272012 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272012&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295444 378153837 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 514040 OC(=O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(Cl)cn3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H17Cl2N5O5/c24-15-3-1-14(2-4-15)12-29-21(28-22(33)30(23(29)34)13-20(31)32)27-17-6-8-18(9-7-17)35-19-10-5-16(25)11-26-19/h1-11H,12-13H2,(H,31,32)(H,27,28,33) JTIYNNXDVVNETA-UHFFFAOYSA-N 272013 US10065941, Compound R-312::US9732060, Compound R-312 P2X purinoceptor 3 Homo sapiens 350 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272013 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272013&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752252 378153838 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 514041 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(F)cn3)cc2)n(CC2CCC3(CC3)CC2)c1=O 272014 US10065941, Compound I-237::US9732060, Compound I-237 P2X purinoceptor 3 Homo sapiens 14.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272014 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272014&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752237 378153839 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 514042 CCOC(=O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(cn3)C#N)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H21ClN6O5/c1-2-37-23(34)16-33-25(35)31-24(32(26(33)36)15-17-3-6-19(27)7-4-17)30-20-8-10-21(11-9-20)38-22-12-5-18(13-28)14-29-22/h3-12,14H,2,15-16H2,1H3,(H,30,31,35) MURBJSZYMOUPML-UHFFFAOYSA-N 272015 US10065941, Compound R-313::US9732060, Compound R-313 P2X purinoceptor 3 Homo sapiens 3.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272015 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272015&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295680 378153840 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 514043 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(CF)cn3)cc2)n(Cc2ccc(Cl)cc2)c1=O 272016 US10065941, Compound I-238::US9732060, Compound I-238 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272016 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272016&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295446 378153841 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 514044 OC(=O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(cn3)C#N)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H17ClN6O5/c25-17-4-1-15(2-5-17)13-30-22(29-23(34)31(24(30)35)14-21(32)33)28-18-6-8-19(9-7-18)36-20-10-3-16(11-26)12-27-20/h1-10,12H,13-14H2,(H,32,33)(H,28,29,34) DPLICNAZDYZBIZ-UHFFFAOYSA-N 272017 US10065941, Compound R-314::US9732060, Compound R-314 P2X purinoceptor 3 Homo sapiens 48.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272017 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272017&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295681 378153842 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 514045 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(CF)nc3)cc2)n(Cc2ccc(Cl)cc2)c1=O 272018 US10065941, Compound I-239::US9732060, Compound I-239 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272018 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272018&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295445 378153843 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 514046 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cc(CO)ccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 272019 US10065941, Compound I-240::US9732060, Compound I-240 P2X purinoceptor 3 Homo sapiens 22.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272019 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272019&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295448 378153844 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 514047 COCc1ccc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n2Cc2ccc(Cl)cc2)nc1 272020 US10065941, Compound I-241::US9732060, Compound I-241 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272020 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272020&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295447 378153845 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 514048 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(CF)cn3)cc2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 272021 US10065941, Compound I-242::US9732060, Compound I-242 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272021 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272021&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752296 378153846 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 514049 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)c(Cl)c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 272022 US10065941, Compound I-243::US9732060, Compound I-243 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272022 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272022&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752297 378153847 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 514050 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)c(F)c2)n(C[C@H]2CC[C@H](C)CC2)c1=O)C(O)=O 272023 US10065941, Compound I-244::US9732060, Compound I-244 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272023 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272023&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752292 378153848 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 514051 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(CO)n3)cc2)n(Cc2ccc(Cl)cc2)c1=O 272024 US10065941, Compound I-245::US9732060, Compound I-245 P2X purinoceptor 3 Homo sapiens 14.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272024 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272024&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295449 378153849 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 514052 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(CO)n3)cc2)n(Cc2ccc(C)cc2)c1=O 272025 US10065941, Compound I-246::US9732060, Compound I-246 P2X purinoceptor 3 Homo sapiens 14.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272025 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272025&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752355 378153850 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 514053 COCc1ccc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(C[C@H](C)C(=O)OC)c(=O)n2Cc2ccc(Cl)cc2)nc1 272026 US10065941, Compound I-247::US9732060, Compound I-247 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272026 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272026&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295450 378153851 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 514054 COCc1ccc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(C[C@H](C)C(=O)OC)c(=O)n2Cc2ccc(C)cc2)nc1 272027 US10065941, Compound I-248::US9732060, Compound I-248 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272027 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272027&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752375 378153852 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 514055 COCc1cccc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(C[C@H](C)C(=O)OC)c(=O)n2Cc2ccc(Cl)cc2)n1 272028 US10065941, Compound I-249::US9732060, Compound I-249 P2X purinoceptor 3 Homo sapiens 36.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272028 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272028&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752357 378153853 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 514056 COCc1cccc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(C[C@H](C)C(=O)OC)c(=O)n2Cc2ccc(C)cc2)n1 272029 US10065941, Compound I-250::US9732060, Compound I-250 P2X purinoceptor 3 Homo sapiens 31.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272029 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272029&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295452 378153854 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 514057 CCc1ccc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(C[C@H](C)C(=O)OC)c(=O)n2Cc2ccc(Cl)cc2)nc1 272030 US10065941, Compound I-251::US9732060, Compound I-251 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272030 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272030&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295451 378153855 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 514058 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)c(Cl)c2)n(Cc2ccc(Cl)cc2)c1=O 272031 US10065941, Compound I-252::US9732060, Compound I-252 P2X purinoceptor 3 Homo sapiens 14.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272031 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272031&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752123 378153856 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 514059 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)c(F)c2)n(Cc2ccc(C)cc2)c1=O 271948 US10065941, Compound I-204::US10065941, Compound I-253::US9732060, Compound I-204 P2X purinoceptor 3 Homo sapiens 9.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271948 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271948&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752354 378153773 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 514060 COCc1ccc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n2Cc2ccc(C)cc2)nc1 272033 US10065941, Compound I-254::US9732060, Compound I-254 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272033 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272033&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752124 378153857 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 514061 COCc1cccc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n2Cc2ccc(Cl)cc2)n1 272034 US10065941, Compound I-255::US9732060, Compound I-255 P2X purinoceptor 3 Homo sapiens 18.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272034 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272034&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752203 378153858 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 514062 COCc1cccc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n2Cc2ccc(C)cc2)n1 272035 US10065941, Compound I-256::US9732060, Compound I-256 P2X purinoceptor 3 Homo sapiens 29.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272035 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272035&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295454 378153859 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 514063 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(CO)n3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 272036 US10065941, Compound I-257::US9732060, Compound I-257 P2X purinoceptor 3 Homo sapiens 16.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272036 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272036&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752239 378153860 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 514064 CCc1ccc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n2Cc2ccc(Cl)cc2)nc1 272037 US10065941, Compound I-258::US9732060, Compound I-258 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272037 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272037&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295453 378153861 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 514065 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(cn3)C(C)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 272038 US10065941, Compound I-259::US9732060, Compound I-259 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272038 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272038&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295455 378153862 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 514066 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(cn3)C(C)=O)cc2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 272039 US10065941, Compound I-260::US9732060, Compound I-260 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272039 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272039&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752367 378153863 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 514067 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(CF)n3)cc2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 272040 US10065941, Compound I-261::US9732060, Compound I-261 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272040 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272040&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752358 378153864 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 514068 CC(O)c1ccc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n2Cc2ccc(C)cc2)nc1 272041 US10065941, Compound I-262::US9732060, Compound I-262 P2X purinoceptor 3 Homo sapiens 7.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272041 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272041&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295456 378153865 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 514069 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(CC2CC3(CCC3)C2)c1=O)C(O)=O 272042 US10065941, Compound I-263::US9732060, Compound I-263 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272042 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272042&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295457 378153866 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 514070 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(F)cn3)cc2)n(CC2CC3(CCC3)C2)c1=O)C(O)=O 272043 US10065941, Compound I-264::US9732060, Compound I-264 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272043 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272043&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752377 378153867 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 514071 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(CI)n3)cc2)n(Cc2ccc(C)cc2)c1=O 272044 US10065941, Compound I-265::US9732060, Compound I-265 P2X purinoceptor 3 Homo sapiens 10.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272044 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272044&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752225 378153868 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 514072 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(CF)n3)cc2)n(Cc2ccc(C)cc2)c1=O 272045 US10065941, Compound I-266::US9732060, Compound I-266 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272045 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272045&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752211 378153869 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 514073 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(cn3)C(C)=O)cc2)n(Cc2ccc(C)cc2)c1=O 272046 US10065941, Compound I-267::US9732060, Compound I-267 P2X purinoceptor 3 Homo sapiens 3.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272046 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272046&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752232 378153870 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 514074 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(CC2CC3(CCC3)C2)c1=O 272047 US10065941, Compound I-268::US9732060, Compound I-268 P2X purinoceptor 3 Homo sapiens 3.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272047 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272047&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752174 378153871 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 514075 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(F)cn3)cc2)n(CC2CC3(CCC3)C2)c1=O 272048 US10065941, Compound I-269::US9732060, Compound I-269 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272048 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272048&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752233 378153872 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 514076 CCc1ccc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(C[C@H](C)C(=O)OC)c(=O)n2Cc2ccc(C)cc2)nc1 272049 US10065941, Compound I-270::US9732060, Compound I-270 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272049 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272049&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752125 378153873 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 514077 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(Cc2ccc(Cl)s2)c1=O 272050 US10065941, Compound I-271::US9732060, Compound I-271 P2X purinoceptor 3 Homo sapiens 10.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272050 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272050&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752126 378153874 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 514078 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(F)cn3)cc2)n(Cc2ccc(Cl)s2)c1=O 272051 US10065941, Compound I-272::US9732060, Compound I-272 P2X purinoceptor 3 Homo sapiens 8.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272051 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272051&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752127 378153875 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 514079 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(Cc2ccc(Cl)s2)c1=O)C(O)=O 272052 US10065941, Compound I-273::US9732060, Compound I-273 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272052 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272052&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752131 378153876 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 514080 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(F)cn3)cc2)n(Cc2ccc(Cl)s2)c1=O)C(O)=O 272053 US10065941, Compound I-274::US9732060, Compound I-274 P2X purinoceptor 3 Homo sapiens 5.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272053 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272053&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752128 378153877 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 514081 CCc1ccc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n2Cc2ccc(C)cc2)nc1 272054 US10065941, Compound I-275::US9732060, Compound I-275 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272054 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272054&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295459 378153878 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 514082 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ncccc3F)c(C)c2)n(Cc2ccc(Cl)s2)c1=O)C(O)=O 272055 US10065941, Compound I-276::US9732060, Compound I-276 P2X purinoceptor 3 Homo sapiens 19.0 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272055 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272055&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295460 378153879 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 514083 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(cn3)S(C)(=O)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O 272056 US10065941, Compound I-277::US9732060, Compound I-277 P2X purinoceptor 3 Homo sapiens 4.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272056 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272056&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295462 378153880 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 514084 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(cn3)S(C)(=O)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 272057 US10065941, Compound I-278::US9732060, Compound I-278 P2X purinoceptor 3 Homo sapiens 6.00 7.5 US Patent 10.7270/Q28P62J8 aid1795452 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272057 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272057&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295461 378153881 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 514085 OC(=O)[C@H]1C[C@@H](C1)n1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(F)cn3)cc2)n(Cc2ccc(Cl)cc2)c1=O 271518 US10065941, Compound I-019::US9732060, Compound I-019 P2X purinoceptor 3 Homo sapiens 68.0 7.5 US Patent 10.7270/Q28P62J8 aid1795453 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271518 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271518&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752079 378153346 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 514086 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(F)cn3)cc2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 271539 US10065941, Compound I-040::US10065941, Compound I-130::US9732060, Compound I-130 P2X purinoceptor 3 Homo sapiens 18.0 7.5 US Patent 10.7270/Q28P62J8 aid1795453 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271539 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271539&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752335 378153367 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 514087 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ncccc3F)cc2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 271555 US10065941, Compound I-056::US9732060, Compound I-056 P2X purinoceptor 3 Homo sapiens 23.0 7.5 US Patent 10.7270/Q28P62J8 aid1795453 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271555 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271555&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752329 378153383 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 514088 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cc(F)ccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271569 US10065941, Compound I-070::US9732060, Compound I-070 P2X purinoceptor 3 Homo sapiens 37.0 7.5 US Patent 10.7270/Q28P62J8 aid1795453 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271569 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271569&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752201 378153397 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 514089 COc1ccc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n2Cc2ccc(Cl)cc2)nc1 271578 US10065941, Compound I-079::US9732060, Compound I-079 P2X purinoceptor 3 Homo sapiens 37.0 7.5 US Patent 10.7270/Q28P62J8 aid1795453 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271578 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271578&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752076 378153406 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 514090 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccnc(c3)C#N)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271808 US10065941, Compound R-123::US9732060, Compound R-123 P2X purinoceptor 3 Homo sapiens 18.0 7.5 US Patent 10.7270/Q28P62J8 aid1795453 US10065941 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271808 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271808&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295562 378153634 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 631996 C[C@@H](NC(=O)c1cc(OCC2CC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C22H21F3N4O2S/c1-12-8-26-20(32-12)16-5-15(6-18(7-16)31-11-14-3-4-14)19(30)29-13(2)17-9-27-21(28-10-17)22(23,24)25/h5-10,13-14H,3-4,11H2,1-2H3,(H,29,30)/t13-/m1/s1 KPIHUQDIFGXEHA-CYBMUJFWSA-N 319834 3-(Cyclopropylmethoxy)-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 1::US10202369, Example 1::US10472354, Example 1 P2X purinoceptor 3 Homo sapiens 4.00 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319834 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319834&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397250 384223114 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 631998 Cc1cnc(s1)-c1cc(OCC2CC2)cc(c1)C(=O)NCc1ccc(C)nn1 InChI=1S/C21H22N4O2S/c1-13-3-6-18(25-24-13)11-22-20(26)16-7-17(21-23-10-14(2)28-21)9-19(8-16)27-12-15-4-5-15/h3,6-10,15H,4-5,11-12H2,1-2H3,(H,22,26) LHMIEJIRNSAGER-UHFFFAOYSA-N 319835 3-(Cyclopropylmethoxy)-N-[(6-methylpyridazin-3-yl)methyl]-5-(5-methyl-1,3-thiazol-2-yl)benzamide::US10174016, Example 2::US10202369, Example 2::US10472354, Example 2 P2X purinoceptor 3 Homo sapiens 19.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319835 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319835&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397260 384223115 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632000 Cc1cnc(s1)-c1cc(OCC2CC2)cc(c1)C(=O)NCc1cnc(C)cn1 InChI=1S/C21H22N4O2S/c1-13-8-23-18(10-22-13)11-24-20(26)16-5-17(21-25-9-14(2)28-21)7-19(6-16)27-12-15-3-4-15/h5-10,15H,3-4,11-12H2,1-2H3,(H,24,26) SHCAJJQUYCQWRM-UHFFFAOYSA-N 319836 3-(Cyclopropylmethoxy)-N-[(5-methylpyrazin-2-yl)methyl]-5-(5-methyl-1,3-thiazol-2-yl)benzamide::US10174016, Example 3::US10202369, Example 3::US10472354, Example 3 P2X purinoceptor 3 Homo sapiens 26.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319836 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319836&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397194 384223116 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632002 C[C@@H](NC(=O)c1cc(OCC2CC2)cc(c1)-c1ncc(C)s1)c1cnc(C)cn1 InChI=1S/C22H24N4O2S/c1-13-9-24-20(11-23-13)15(3)26-21(27)17-6-18(22-25-10-14(2)29-22)8-19(7-17)28-12-16-4-5-16/h6-11,15-16H,4-5,12H2,1-3H3,(H,26,27)/t15-/m1/s1 DYWYLXQLERQEEM-OAHLLOKOSA-N 319837 3-(Cyclopropylmethoxy)-N-[(1R)-1-(5-methylpyrazin-2-yl)ethyl]-5-(5-methyl-1,3-thiazol-2-yl)benzamide::US10174016, Example 4::US10202369, Example 4::US10472354, Example 4 P2X purinoceptor 3 Homo sapiens 9.00 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319837 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319837&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397428 384223117 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632004 CC(NC(=O)c1cc(OCC2CC2)cc(c1)-c1ncc(C)s1)c1ncc(F)cc1Cl InChI=1S/C22H21ClFN3O2S/c1-12-9-26-22(30-12)16-5-15(6-18(7-16)29-11-14-3-4-14)21(28)27-13(2)20-19(23)8-17(24)10-25-20/h5-10,13-14H,3-4,11H2,1-2H3,(H,27,28) CGCJNRQFWMKWFU-UHFFFAOYSA-N 319838 N-[1-(3-Chloro-5-fluoropyridin-2-yl)ethyl]-3-(cyclopropylmethoxy)-5-(5-methyl-1,3-thiazol-2-yl)benzamide::US10174016, Example 5::US10202369, Example 5::US10472354, Example 5 P2X purinoceptor 3 Homo sapiens 16.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319838 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319838&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397491 384223118 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625288 C[C@@H](NC(=O)c1cc(OCC2CC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C22H21F3N4O2S/c1-12-8-26-20(32-12)16-5-15(6-18(7-16)31-11-14-3-4-14)19(30)29-13(2)17-9-27-21(28-10-17)22(23,24)25/h5-10,13-14H,3-4,11H2,1-2H3,(H,29,30)/t13-/m1/s1 KPIHUQDIFGXEHA-CYBMUJFWSA-N 319834 3-(Cyclopropylmethoxy)-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 1::US10202369, Example 1::US10472354, Example 1 P2X purinoceptor 3 Homo sapiens 4.00 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319834 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319834&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397250 384223114 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625290 Cc1cnc(s1)-c1cc(OCC2CC2)cc(c1)C(=O)NCc1ccc(C)nn1 InChI=1S/C21H22N4O2S/c1-13-3-6-18(25-24-13)11-22-20(26)16-7-17(21-23-10-14(2)28-21)9-19(8-16)27-12-15-4-5-15/h3,6-10,15H,4-5,11-12H2,1-2H3,(H,22,26) LHMIEJIRNSAGER-UHFFFAOYSA-N 319835 3-(Cyclopropylmethoxy)-N-[(6-methylpyridazin-3-yl)methyl]-5-(5-methyl-1,3-thiazol-2-yl)benzamide::US10174016, Example 2::US10202369, Example 2::US10472354, Example 2 P2X purinoceptor 3 Homo sapiens 19.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319835 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319835&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397260 384223115 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625292 Cc1cnc(s1)-c1cc(OCC2CC2)cc(c1)C(=O)NCc1cnc(C)cn1 InChI=1S/C21H22N4O2S/c1-13-8-23-18(10-22-13)11-24-20(26)16-5-17(21-25-9-14(2)28-21)7-19(6-16)27-12-15-3-4-15/h5-10,15H,3-4,11-12H2,1-2H3,(H,24,26) SHCAJJQUYCQWRM-UHFFFAOYSA-N 319836 3-(Cyclopropylmethoxy)-N-[(5-methylpyrazin-2-yl)methyl]-5-(5-methyl-1,3-thiazol-2-yl)benzamide::US10174016, Example 3::US10202369, Example 3::US10472354, Example 3 P2X purinoceptor 3 Homo sapiens 26.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319836 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319836&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397194 384223116 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625294 C[C@@H](NC(=O)c1cc(OCC2CC2)cc(c1)-c1ncc(C)s1)c1cnc(C)cn1 InChI=1S/C22H24N4O2S/c1-13-9-24-20(11-23-13)15(3)26-21(27)17-6-18(22-25-10-14(2)29-22)8-19(7-17)28-12-16-4-5-16/h6-11,15-16H,4-5,12H2,1-3H3,(H,26,27)/t15-/m1/s1 DYWYLXQLERQEEM-OAHLLOKOSA-N 319837 3-(Cyclopropylmethoxy)-N-[(1R)-1-(5-methylpyrazin-2-yl)ethyl]-5-(5-methyl-1,3-thiazol-2-yl)benzamide::US10174016, Example 4::US10202369, Example 4::US10472354, Example 4 P2X purinoceptor 3 Homo sapiens 9.00 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319837 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319837&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397428 384223117 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625296 CC(NC(=O)c1cc(OCC2CC2)cc(c1)-c1ncc(C)s1)c1ncc(F)cc1Cl InChI=1S/C22H21ClFN3O2S/c1-12-9-26-22(30-12)16-5-15(6-18(7-16)29-11-14-3-4-14)21(28)27-13(2)20-19(23)8-17(24)10-25-20/h5-10,13-14H,3-4,11H2,1-2H3,(H,27,28) CGCJNRQFWMKWFU-UHFFFAOYSA-N 319838 N-[1-(3-Chloro-5-fluoropyridin-2-yl)ethyl]-3-(cyclopropylmethoxy)-5-(5-methyl-1,3-thiazol-2-yl)benzamide::US10174016, Example 5::US10202369, Example 5::US10472354, Example 5 P2X purinoceptor 3 Homo sapiens 16.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319838 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319838&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397491 384223118 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625298 CC(NC(=O)c1cc(OCC2CC2)cc(c1)-c1ncc(C)s1)c1ncc(Cl)cc1F InChI=1S/C22H21ClFN3O2S/c1-12-9-26-22(30-12)16-5-15(6-18(7-16)29-11-14-3-4-14)21(28)27-13(2)20-19(24)8-17(23)10-25-20/h5-10,13-14H,3-4,11H2,1-2H3,(H,27,28) YIPUFXDTAKNGSX-UHFFFAOYSA-N 319839 N-[1-(5-Chloro-3-fluoropyridin-2-yl)ethyl]-3-(cyclopropylmethoxy)-5-(5-methyl-1,3-thiazol-2-yl)benzamide::US10174016, Example 6::US10202369, Example 6::US10472354, Example 6 P2X purinoceptor 3 Homo sapiens 4.00 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319839 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319839&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397488 384223119 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625300 C[C@@H](NC(=O)c1cc(OCC2CC2)cc(c1)-c1ncc(C)s1)c1nnc(C)s1 InChI=1S/C20H22N4O2S2/c1-11-9-21-20(27-11)16-6-15(7-17(8-16)26-10-14-4-5-14)18(25)22-12(2)19-24-23-13(3)28-19/h6-9,12,14H,4-5,10H2,1-3H3,(H,22,25)/t12-/m1/s1 QOCVVHCSVZQPAR-GFCCVEGCSA-N 319840 3-(Cyclopropylmethoxy)-N-[(1R)-1-(5-methyl-1,3,4-thiadiazol-2-yl)ethyl]-5-(5-methyl-1,3-thiazol-2-yl)benzamide::US10174016, Example 7::US10202369, Example 7::US10472354, Example 7 P2X purinoceptor 3 Homo sapiens 8.00 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319840 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319840&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397154 384223120 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625302 C[C@@H](NC(=O)c1cc(OCC2CC2)cc(c1)-c1ncc(C)s1)c1ccc(C)nn1 InChI=1S/C22H24N4O2S/c1-13-4-7-20(26-25-13)15(3)24-21(27)17-8-18(22-23-11-14(2)29-22)10-19(9-17)28-12-16-5-6-16/h4,7-11,15-16H,5-6,12H2,1-3H3,(H,24,27)/t15-/m1/s1 ZZPHBEIBURIANJ-OAHLLOKOSA-N 319841 3-(Cyclopropylmethoxy)-N-[(1R)-1-(6-methylpyridazin-3-yl)ethyl]-5-(5-methyl-1,3-thiazol-2-yl)benzamide::US10174016, Example 8::US10202369, Example 8::US10472354, Example 8 P2X purinoceptor 3 Homo sapiens 3.00 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319841 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319841&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397204 384223121 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625304 C[C@@H](NC(=O)c1cc(OCC2CC2)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F InChI=1S/C22H21F3N4O2S/c1-12-10-26-21(32-12)16-7-15(8-17(9-16)31-11-14-3-4-14)20(30)27-13(2)18-5-6-19(29-28-18)22(23,24)25/h5-10,13-14H,3-4,11H2,1-2H3,(H,27,30)/t13-/m1/s1 FDEHTNMFMQMRCT-CYBMUJFWSA-N 319842 3-(Cyclopropylmethoxy)-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[6-(trifluoromethyl)pyridazin-3-yl]ethyl}benzamide::US10174016, Example 9::US10202369, Example 9::US10472354, Example 9 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319842 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319842&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397573 384223122 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625306 C[C@@H](NC(=O)c1cc(OCC2CC2)cc(c1)-c1ncc(C)s1)c1cnc(C)nc1 InChI=1S/C22H24N4O2S/c1-13-9-25-22(29-13)18-6-17(7-20(8-18)28-12-16-4-5-16)21(27)26-14(2)19-10-23-15(3)24-11-19/h6-11,14,16H,4-5,12H2,1-3H3,(H,26,27)/t14-/m1/s1 HEHYSAYIHLPEGC-CQSZACIVSA-N 319843 3-(Cyclopropylmethoxy)-N-[(1R)-1-(2-methylpyrimidin-5-yl)ethyl]-5-(5-methyl-1,3-thiazol-2-yl)benzamide::US10174016, Example 10::US10202369, Example 10::US10472354, Example 10 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319843 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319843&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397702 384223123 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625308 C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C22H21F3N4O3S/c1-12-8-26-20(33-12)15-5-14(6-18(7-15)32-17-3-4-31-11-17)19(30)29-13(2)16-9-27-21(28-10-16)22(23,24)25/h5-10,13,17H,3-4,11H2,1-2H3,(H,29,30)/t13-,17-/m1/s1 GTQPEQGDLVSFJO-CXAGYDPISA-N 319844 3-(5-Methyl-1,3-thiazol-2-yl)-5-[(3R)-tetrahydrofuran-3-yloxy]-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 11::US10202369, Example 11::US10472354, Example 291 P2X purinoceptor 3 Homo sapiens 8.00 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319844 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319844&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397587 384223124 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625310 Cc1cnc(s1)-c1cc(O[C@@H]2CCOC2)cc(c1)C(=O)NCc1cnc(C)cn1 InChI=1S/C21H22N4O3S/c1-13-8-23-17(10-22-13)11-24-20(26)15-5-16(21-25-9-14(2)29-21)7-19(6-15)28-18-3-4-27-12-18/h5-10,18H,3-4,11-12H2,1-2H3,(H,24,26)/t18-/m1/s1 SKCSTCBULJTUPE-GOSISDBHSA-N 319845 N-[(5-methylpyrazin-2-yl)methyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(3R)-tetrahydrofuran-3-yloxy]benzamide::US10174016, Example 12::US10202369, Example 12 P2X purinoceptor 3 Homo sapiens 283 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319845 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319845&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397167 384223125 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625312 CC(NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ncc(F)cc1Cl InChI=1S/C22H21ClFN3O3S/c1-12-9-26-22(31-12)15-5-14(6-18(7-15)30-17-3-4-29-11-17)21(28)27-13(2)20-19(23)8-16(24)10-25-20/h5-10,13,17H,3-4,11H2,1-2H3,(H,27,28)/t13?,17-/m1/s1 YETTUNLUNMEXML-LRHAYUFXSA-N 319846 N-[1-(3-chloro-5-fluoropyridin-2-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(3R)-tetrahydrofuran-3-yloxy]benzamide::US10174016, Example 13::US10202369, Example 13::US10472354, Example 13 P2X purinoceptor 3 Homo sapiens 21.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319846 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319846&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397669 384223126 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625314 CC(NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ncc(Cl)cc1F InChI=1S/C22H21ClFN3O3S/c1-12-9-26-22(31-12)15-5-14(6-18(7-15)30-17-3-4-29-11-17)21(28)27-13(2)20-19(24)8-16(23)10-25-20/h5-10,13,17H,3-4,11H2,1-2H3,(H,27,28)/t13?,17-/m1/s1 DLODQDUFIVUCLQ-LRHAYUFXSA-N 319847 N-[1-(5-chloro-3-fluoropyridin-2-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(3R)-tetrahydrofuran-3-yloxy]benzamide::US10174016, Example 14::US10202369, Example 14::US10472354, Example 14 P2X purinoceptor 3 Homo sapiens 8.00 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319847 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319847&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397583 384223127 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625316 C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ccc(Cl)cn1 InChI=1S/C22H22ClN3O3S/c1-13-10-25-22(30-13)16-7-15(8-19(9-16)29-18-5-6-28-12-18)21(27)26-14(2)20-4-3-17(23)11-24-20/h3-4,7-11,14,18H,5-6,12H2,1-2H3,(H,26,27)/t14-,18-/m1/s1 DURBVTDNVKUTOV-RDTXWAMCSA-N 319848 N-[(1R)-1-(5-chloropyridin-2-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(3R)-tetrahydrofuran-3-yloxy]benzamide::US10174016, Example 15::US10202369, Example 15::US10472354, Example 15 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319848 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319848&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397630 384223128 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625318 C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1cnc(C)cn1 InChI=1S/C22H24N4O3S/c1-13-9-24-20(11-23-13)15(3)26-21(27)16-6-17(22-25-10-14(2)30-22)8-19(7-16)29-18-4-5-28-12-18/h6-11,15,18H,4-5,12H2,1-3H3,(H,26,27)/t15-,18-/m1/s1 GGLGXVJJVCGSBA-CRAIPNDOSA-N 319849 N-[(1R)-1-(5-methylpyrazin-2-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(3R)-tetrahydrofuran-3-yloxy]benzamide::US10174016, Example 16::US10202369, Example 16::US10472354, Example 16 P2X purinoceptor 3 Homo sapiens 38.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319849 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319849&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397267 384223129 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625320 Cc1cnc(s1)-c1cc(O[C@@H]2CCOC2)cc(c1)C(=O)NCc1ccc(C)nn1 InChI=1S/C21H22N4O3S/c1-13-3-4-17(25-24-13)11-22-20(26)15-7-16(21-23-10-14(2)29-21)9-19(8-15)28-18-5-6-27-12-18/h3-4,7-10,18H,5-6,11-12H2,1-2H3,(H,22,26)/t18-/m1/s1 VKRRMZCTKMLCQJ-GOSISDBHSA-N 319850 N-[(6-methylpyridazin-3-yl)methyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(3R)-tetrahydrofuran-3-yloxy]benzamide::US10174016, Example 17::US10202369, Example 17::US10472354, Example 17 P2X purinoceptor 3 Homo sapiens 35.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319850 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319850&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397146 384223130 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625322 C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ccc(C)nn1 InChI=1S/C22H24N4O3S/c1-13-4-5-20(26-25-13)15(3)24-21(27)16-8-17(22-23-11-14(2)30-22)10-19(9-16)29-18-6-7-28-12-18/h4-5,8-11,15,18H,6-7,12H2,1-3H3,(H,24,27)/t15-,18-/m1/s1 JJXMVDHMQZPOJY-CRAIPNDOSA-N 319851 N-[(1R)-1-(6-methylpyridazin-3-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(3R)-tetrahydrofuran-3-yloxy]benzamide::US10174016, Example 18::US10202369, Example 18::US10472354, Example 18 P2X purinoceptor 3 Homo sapiens 34.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319851 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319851&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397758 384223131 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625324 C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F InChI=1S/C22H21F3N4O3S/c1-12-10-26-21(33-12)15-7-14(8-17(9-15)32-16-5-6-31-11-16)20(30)27-13(2)18-3-4-19(29-28-18)22(23,24)25/h3-4,7-10,13,16H,5-6,11H2,1-2H3,(H,27,30)/t13-,16-/m1/s1 DNHMMXLROIMBSA-CZUORRHYSA-N 319852 3-(5-Methyl-1,3-thiazol-2-yl)-5-[(3R)-tetrahydrofuran-3-yloxy]-N-{(1R)-1-[6-(trifluoromethyl)pyridazin-3-yl]ethyl}benzamide::US10174016, Example 19::US10202369, Example 19::US10472354, Example 19 P2X purinoceptor 3 Homo sapiens 19.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319852 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319852&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397747 384223132 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625326 C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1nnc(C)s1 InChI=1S/C20H22N4O3S2/c1-11-9-21-20(28-11)15-6-14(7-17(8-15)27-16-4-5-26-10-16)18(25)22-12(2)19-24-23-13(3)29-19/h6-9,12,16H,4-5,10H2,1-3H3,(H,22,25)/t12-,16-/m1/s1 WVNVOAPVSAUSTP-MLGOLLRUSA-N 319853 N-[(1R)-1-(5-methyl-1,3,4-thiadiazol-2-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(3R)-tetrahydrofuran-3-yloxy]benzamide::US10174016, Example 20::US10202369, Example 20::US10472354, Example 20 P2X purinoceptor 3 Homo sapiens 35.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319853 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319853&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397835 384223133 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625328 Cc1cnc(s1)-c1cc(O[C@@H]2CCOC2)cc(c1)C(=O)NCc1ccc(nn1)C(F)(F)F InChI=1S/C21H19F3N4O3S/c1-12-9-26-20(32-12)14-6-13(7-17(8-14)31-16-4-5-30-11-16)19(29)25-10-15-2-3-18(28-27-15)21(22,23)24/h2-3,6-9,16H,4-5,10-11H2,1H3,(H,25,29)/t16-/m1/s1 YZCYRJHHBOIVER-MRXNPFEDSA-N 319854 3-(5-Methyl-1,3-thiazol-2-yl)-5-[(3R)-tetrahydrofuran-3-yloxy]-N-{[6-(trifluoromethyl)pyridazin-3-yl]methyl}benzamide::US10174016, Example 21::US10202369, Example 21::US10472354, Example 21 P2X purinoceptor 3 Homo sapiens 71.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319854 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319854&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397575 384223134 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625330 CC[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H23F3N4O3S/c1-3-19(16-10-28-22(29-11-16)23(24,25)26)30-20(31)14-6-15(21-27-9-13(2)34-21)8-18(7-14)33-17-4-5-32-12-17/h6-11,17,19H,3-5,12H2,1-2H3,(H,30,31)/t17-,19-/m1/s1 VUXDKUAYZMWTBM-IEBWSBKVSA-N 319855 3-(5-Methyl-1,3-thiazol-2-yl)-5-[(3R)-tetrahydrofuran-3-yloxy]-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]propyl}benzamide::US10174016, Example 22::US10202369, Example 22::US10472354, Example 22 P2X purinoceptor 3 Homo sapiens 132 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319855 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319855&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397246 384223135 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625332 C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1cnc(C)nc1 InChI=1S/C22H24N4O3S/c1-13-9-25-22(30-13)17-6-16(7-20(8-17)29-19-4-5-28-12-19)21(27)26-14(2)18-10-23-15(3)24-11-18/h6-11,14,19H,4-5,12H2,1-3H3,(H,26,27)/t14-,19-/m1/s1 RHVHBKMOULQMJQ-AUUYWEPGSA-N 319856 N-[(1R)-1-(2-Methylpyrimidin-5-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(3R)-tetrahydrofuran-3-yloxy]benzamide::US10174016, Example 23::US10202369, Example 23 P2X purinoceptor 3 Homo sapiens 30.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319856 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319856&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397288 384223136 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625334 C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ccc(C)nc1 InChI=1S/C23H25N3O3S/c1-14-4-5-17(12-24-14)16(3)26-22(27)18-8-19(23-25-11-15(2)30-23)10-21(9-18)29-20-6-7-28-13-20/h4-5,8-12,16,20H,6-7,13H2,1-3H3,(H,26,27)/t16-,20-/m1/s1 KGDPEGCMVCXNPY-OXQOHEQNSA-N 319857 N-[(1R)-1-(6-Methylpyridin-3-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(3R)-tetrahydrofuran-3-yloxy]benzamide::US10174016, Example 24::US10202369, Example 24 P2X purinoceptor 3 Homo sapiens 36.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319857 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319857&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397467 384223137 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625336 C[C@@H](NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ccc(C)nn1 InChI=1S/C22H24N4O3S/c1-13-4-5-20(26-25-13)15(3)24-21(27)16-8-17(22-23-11-14(2)30-22)10-19(9-16)29-18-6-7-28-12-18/h4-5,8-11,15,18H,6-7,12H2,1-3H3,(H,24,27)/t15-,18+/m1/s1 JJXMVDHMQZPOJY-QAPCUYQASA-N 319858 N-[(1R)-1-(6-Methylpyridazin-3-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(3S)-tetrahydrofuran-3-yloxy]benzamide::US10174016, Example 25::US10202369, Example 25::US10472354, Example 25 P2X purinoceptor 3 Homo sapiens 39.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319858 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319858&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397569 384223138 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632006 CC(NC(=O)c1cc(OCC2CC2)cc(c1)-c1ncc(C)s1)c1ncc(Cl)cc1F InChI=1S/C22H21ClFN3O2S/c1-12-9-26-22(30-12)16-5-15(6-18(7-16)29-11-14-3-4-14)21(28)27-13(2)20-19(24)8-17(23)10-25-20/h5-10,13-14H,3-4,11H2,1-2H3,(H,27,28) YIPUFXDTAKNGSX-UHFFFAOYSA-N 319839 N-[1-(5-Chloro-3-fluoropyridin-2-yl)ethyl]-3-(cyclopropylmethoxy)-5-(5-methyl-1,3-thiazol-2-yl)benzamide::US10174016, Example 6::US10202369, Example 6::US10472354, Example 6 P2X purinoceptor 3 Homo sapiens 4.00 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319839 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319839&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397488 384223119 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632134 C[C@@H](NC(=O)c1cc(OC[C@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H23F3N4O3S/c1-13-8-27-21(34-13)17-5-16(6-19(7-17)33-12-15-3-4-32-11-15)20(31)30-14(2)18-9-28-22(29-10-18)23(24,25)26/h5-10,14-15H,3-4,11-12H2,1-2H3,(H,30,31)/t14-,15+/m1/s1 CHPCVIFXIKJNGF-CABCVRRESA-N 319903 3-(5-Methyl- 1,3-thiazol-2- yl)-5-[(3S)- tetrahydrofuran- 3-ylmethoxy]- N-[(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl] benzamide::US10174016, Example 70::US10202369, Example 70::US10472354, Example 70 P2X purinoceptor 3 Homo sapiens 3.00 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319903 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319903&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397748 384223183 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632136 C[C@@H](NC(=O)c1cc(OC[C@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ccc(C)nn1 InChI=1S/C23H26N4O3S/c1-14-4-5-21(27-26-14)16(3)25-22(28)18-8-19(23-24-11-15(2)31-23)10-20(9-18)30-13-17-6-7-29-12-17/h4-5,8-11,16-17H,6-7,12-13H2,1-3H3,(H,25,28)/t16-,17+/m1/s1 DJBMUKYGNBBQBO-SJORKVTESA-N 319904 N-[(1R)-1-(6- Methylpyridazin- 3-yl)ethyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5-[(3S)- tetrahydrofuran- 3-ylmethoxy] benzamide::US10174016, Example 71::US10202369, Example 71::US10472354, Example 71 P2X purinoceptor 3 Homo sapiens 15.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319904 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319904&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397305 384223184 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632138 C[C@@H](NC(=O)c1cc(OC[C@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F InChI=1S/C23H23F3N4O3S/c1-13-10-27-22(34-13)17-7-16(8-18(9-17)33-12-15-5-6-32-11-15)21(31)28-14(2)19-3-4-20(30-29-19)23(24,25)26/h3-4,7-10,14-15H,5-6,11-12H2,1-2H3,(H,28,31)/t14-,15+/m1/s1 BICIIZABCQYPPY-CABCVRRESA-N 319905 3-(5-Methyl- 1,3-thiazol-2- yl)-5-[(3S)- tetrahydrofuran- 3-ylmethoxy]- N-[(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl] benzamide::US10174016, Example 72::US10202369, Example 72::US10472354, Example 72 P2X purinoceptor 3 Homo sapiens 11.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319905 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319905&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397781 384223185 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632140 C[C@@H](NC(=O)c1cc(OC[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H23F3N4O3S/c1-13-8-27-21(34-13)17-5-16(6-19(7-17)33-12-15-3-4-32-11-15)20(31)30-14(2)18-9-28-22(29-10-18)23(24,25)26/h5-10,14-15H,3-4,11-12H2,1-2H3,(H,30,31)/t14-,15-/m1/s1 CHPCVIFXIKJNGF-HUUCEWRRSA-N 319906 3-(5-Methyl- 1,3-thiazol-2- yl)-5-[(3R)- tetrahydrofuran- 3-ylmethoxy]- N-[(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl] benzamide::US10174016, Example 73::US10202369, Example 73::US10472354, Example 73 P2X purinoceptor 3 Homo sapiens 4.00 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319906 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319906&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397238 384223186 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632142 C[C@@H](NC(=O)c1cc(OC[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1cnc(C)cn1 InChI=1S/C23H26N4O3S/c1-14-9-25-21(11-24-14)16(3)27-22(28)18-6-19(23-26-10-15(2)31-23)8-20(7-18)30-13-17-4-5-29-12-17/h6-11,16-17H,4-5,12-13H2,1-3H3,(H,27,28)/t16-,17-/m1/s1 VCKXOWQZUNTNDF-IAGOWNOFSA-N 319907 N-[(1R)-1-(5- Methylpyrazin- 2-yl)ethyl]- 3-(5-methyl- 1,3-thiazol-2- yl)-5-[(3R)- tetrahydrofuran- 3-ylmethoxy] benzamide::US10174016, Example 74::US10202369, Example 74::US10472354, Example 74 P2X purinoceptor 3 Homo sapiens 14.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319907 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319907&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397532 384223187 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632144 Cc1cnc(s1)-c1cc(OC[C@@H]2CCOC2)cc(c1)C(=O)NCc1ccc(C)nn1 InChI=1S/C22H24N4O3S/c1-14-3-4-19(26-25-14)11-23-21(27)17-7-18(22-24-10-15(2)30-22)9-20(8-17)29-13-16-5-6-28-12-16/h3-4,7-10,16H,5-6,11-13H2,1-2H3,(H,23,27)/t16-/m1/s1 SKNHRCMFBDROGE-MRXNPFEDSA-N 319908 N-[(6- Methylpyridazin- 3-yl)methyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5-[(3R)- tetrahydrofuran- 3-ylmethoxy] benzamide::US10174016, Example 75::US10202369, Example 75::US10472354, Example 75 P2X purinoceptor 3 Homo sapiens 38.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319908 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319908&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397221 384223188 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632146 Cc1cnc(s1)-c1cc(OC[C@@H]2CCOC2)cc(c1)C(=O)NCc1cnc(C)cn1 InChI=1S/C22H24N4O3S/c1-14-8-24-19(10-23-14)11-25-21(27)17-5-18(22-26-9-15(2)30-22)7-20(6-17)29-13-16-3-4-28-12-16/h5-10,16H,3-4,11-13H2,1-2H3,(H,25,27)/t16-/m1/s1 MFTNZVDLSIJVDH-MRXNPFEDSA-N 319909 N-[(5- Methylpyrazin- 2-yl)methyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5-[(3R)- tetrahydrofuran- 3-ylmethoxy] benzamide::US10174016, Example 76::US10202369, Example 76::US10472354, Example 76 P2X purinoceptor 3 Homo sapiens 201 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319909 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319909&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397850 384223189 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632148 C[C@@H](NC(=O)c1cc(OC[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ccc(C)nn1 InChI=1S/C23H26N4O3S/c1-14-4-5-21(27-26-14)16(3)25-22(28)18-8-19(23-24-11-15(2)31-23)10-20(9-18)30-13-17-6-7-29-12-17/h4-5,8-11,16-17H,6-7,12-13H2,1-3H3,(H,25,28)/t16-,17-/m1/s1 DJBMUKYGNBBQBO-IAGOWNOFSA-N 319910 N-[(1R)-1-(6- Methylpyridazin- 3-yl)ethyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5-[(3R)- tetrahydrofuran- 3-ylmethoxy] benzomide::US10174016, Example 77::US10202369, Example 77::US10472354, Example 77 P2X purinoceptor 3 Homo sapiens 10.00 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319910 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319910&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397806 384223190 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632150 CC(NC(=O)c1cc(OC[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ncc(Cl)cc1F InChI=1S/C23H23ClFN3O3S/c1-13-9-27-23(32-13)17-5-16(6-19(7-17)31-12-15-3-4-30-11-15)22(29)28-14(2)21-20(25)8-18(24)10-26-21/h5-10,14-15H,3-4,11-12H2,1-2H3,(H,28,29)/t14?,15-/m1/s1 NHGFOVVSFOISFI-YSSOQSIOSA-N 319911 N-[1-(5- Chloro-3- fluoropyridin- 2-yl)ethyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5-[(3R)- tetrahydrofuran- 3-ylmethoxy] benzamide::US10174016, Example 78::US10202369, Example 78::US10472354, Example 78 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319911 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319911&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397720 384223191 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632152 C[C@@H](NC(=O)c1cc(OC[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F InChI=1S/C23H23F3N4O3S/c1-13-10-27-22(34-13)17-7-16(8-18(9-17)33-12-15-5-6-32-11-15)21(31)28-14(2)19-3-4-20(30-29-19)23(24,25)26/h3-4,7-10,14-15H,5-6,11-12H2,1-2H3,(H,28,31)/t14-,15-/m1/s1 BICIIZABCQYPPY-HUUCEWRRSA-N 319912 3-(5-Methyl- 1,3-thiazol-2- yl)-5-[(3R)- tetrahydrofuran- 3-ylmethoxy]- N-[(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl] benzamide::US10174016, Example 79::US10202369, Example 79::US10472354, Example 79 P2X purinoceptor 3 Homo sapiens 9.00 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319912 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319912&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397596 384223192 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632154 CC(NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(C)s1)c1ncc(F)cc1Cl InChI=1S/C23H23ClFN3O3S/c1-13-11-27-23(32-13)16-7-15(8-19(9-16)31-18-3-5-30-6-4-18)22(29)28-14(2)21-20(24)10-17(25)12-26-21/h7-12,14,18H,3-6H2,1-2H3,(H,28,29) SBZIYANVWYKJKX-UHFFFAOYSA-N 319913 N-[1-(3- Chloro-5- fluoropyridin- 2-yl)ethyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5- (tetrahydro- 2H-pyran-4- yloxy) benzamide::US10174016, Example 80::US10202369, Example 80::US10472354, Example 80 P2X purinoceptor 3 Homo sapiens 12.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319913 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319913&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397324 384223193 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632156 CC(NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(C)s1)c1ncc(Cl)cc1F InChI=1S/C23H23ClFN3O3S/c1-13-11-27-23(32-13)16-7-15(8-19(9-16)31-18-3-5-30-6-4-18)22(29)28-14(2)21-20(25)10-17(24)12-26-21/h7-12,14,18H,3-6H2,1-2H3,(H,28,29) UXQVDYSQMZTJPS-UHFFFAOYSA-N 319914 N-[1-(5- Chloro-3- fluoropyridin- 2-yl)ethyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5- (tetrahydro- 2H-pyran-4- yloxy) benzamide::US10174016, Example 81::US10202369, Example 81::US10472354, Example 81 P2X purinoceptor 3 Homo sapiens 3.00 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319914 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319914&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397622 384223194 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632158 Cc1cnc(s1)-c1cc(OC2CCOCC2)cc(c1)C(=O)NCc1ccc(C)nn1 InChI=1S/C22H24N4O3S/c1-14-3-4-18(26-25-14)13-23-21(27)16-9-17(22-24-12-15(2)30-22)11-20(10-16)29-19-5-7-28-8-6-19/h3-4,9-12,19H,5-8,13H2,1-2H3,(H,23,27) LSYGQIAUTJTZDJ-UHFFFAOYSA-N 319915 N-[(6- Methylpyridazin- 3-yl)methyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5- (tetrahydro- 2H-pyran-4- yloxy) benzamide::US10174016, Example 82::US10202369, Example 82::US10472354, Example 82 P2X purinoceptor 3 Homo sapiens 28.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319915 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319915&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397341 384223195 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632160 Cc1cnc(s1)-c1cc(OC2CCOCC2)cc(c1)C(=O)NCc1cnc(C)cn1 InChI=1S/C22H24N4O3S/c1-14-10-24-18(12-23-14)13-25-21(27)16-7-17(22-26-11-15(2)30-22)9-20(8-16)29-19-3-5-28-6-4-19/h7-12,19H,3-6,13H2,1-2H3,(H,25,27) YXUSESJBYZNMQE-UHFFFAOYSA-N 319916 N-[(5- Methylpyrazin- 2-yl)methyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5- (tetrahydro- 2H-pyran-4- yloxy) benzamide::US10174016, Example 83::US10202369, Example 83::US10472354, Example 83 P2X purinoceptor 3 Homo sapiens 125 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319916 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319916&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397170 384223196 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632162 C[C@@H](NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(C)s1)c1cnc(C)cn1 InChI=1S/C23H26N4O3S/c1-14-11-25-21(13-24-14)16(3)27-22(28)17-8-18(23-26-12-15(2)31-23)10-20(9-17)30-19-4-6-29-7-5-19/h8-13,16,19H,4-7H2,1-3H3,(H,27,28)/t16-/m1/s1 USCQOVGUOPYDKF-MRXNPFEDSA-N 319917 N-[(1R)-1-(5- Methylpyrazin- 2-yl)ethyl]- 3-(5-methyl- 1,3-thiazol-2- yl)-5- (tetrahydro- 2H-pyran-4- yloxy) benzamide::US10174016, Example 84::US10202369, Example 84::US10472354, Example 84 P2X purinoceptor 3 Homo sapiens 26.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319917 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319917&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397618 384223197 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632164 C[C@@H](NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H23F3N4O3S/c1-13-10-27-21(34-13)16-7-15(8-19(9-16)33-18-3-5-32-6-4-18)20(31)30-14(2)17-11-28-22(29-12-17)23(24,25)26/h7-12,14,18H,3-6H2,1-2H3,(H,30,31)/t14-/m1/s1 WGQQHPGXKFPPTQ-CQSZACIVSA-N 319918 3-(5-Methyl- 1,3-thiazol-2- yl)-5- (tetrahydro- 2H-pyran-4- yloxy)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 85::US10202369, Example 85::US10472354, Example 85 P2X purinoceptor 3 Homo sapiens 10.00 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319918 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319918&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397801 384223198 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632166 COc1ccc(cn1)[C@@H](C)NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(C)s1 InChI=1S/C24H27N3O4S/c1-15-13-26-24(32-15)19-10-18(11-21(12-19)31-20-6-8-30-9-7-20)23(28)27-16(2)17-4-5-22(29-3)25-14-17/h4-5,10-14,16,20H,6-9H2,1-3H3,(H,27,28)/t16-/m1/s1 HOSIWEZQKWEZJW-MRXNPFEDSA-N 319919 N-[(1R)-1-(6- Methoxypyridin- 3-yl)ethyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5- (tetrahydro- 2H-pyran-4- yloxy) benzamide::US10174016, Example 86::US10202369, Example 86::US10472354, Example 86 P2X purinoceptor 3 Homo sapiens 12.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319919 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319919&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397310 384223199 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632168 C[C@@H](NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(C)s1)c1ccc(C)nn1 InChI=1S/C23H26N4O3S/c1-14-4-5-21(27-26-14)16(3)25-22(28)17-10-18(23-24-13-15(2)31-23)12-20(11-17)30-19-6-8-29-9-7-19/h4-5,10-13,16,19H,6-9H2,1-3H3,(H,25,28)/t16-/m1/s1 OIHQARAAGWIFBW-MRXNPFEDSA-N 319920 N-[(1R)-1-(6- Methylpyridazin- 3-yl)ethyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5- (tetrahydro- 2H-pyran-4- yloxy) benzamide::US10174016, Example 87::US10202369, Example 87::US10472354, Example 87 P2X purinoceptor 3 Homo sapiens 15.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319920 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319920&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397290 384223200 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632170 COc1ccc(CNC(=O)c2cc(OC3CCOCC3)cc(c2)-c2ncc(C)s2)nn1 InChI=1S/C22H24N4O4S/c1-14-12-24-22(31-14)16-9-15(10-19(11-16)30-18-5-7-29-8-6-18)21(27)23-13-17-3-4-20(28-2)26-25-17/h3-4,9-12,18H,5-8,13H2,1-2H3,(H,23,27) FUPOQWQPMIFATK-UHFFFAOYSA-N 319921 N-[(6- Methoxy- pyridazin-3- yl)methyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5- (tetrahydro- 2H-pyran-4- yloxy) benzamide::US10174016, Example 88::US10202369, Example 88::US10472354, Example 88 P2X purinoceptor 3 Homo sapiens 30.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319921 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319921&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397556 384223201 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632172 C[C@@H](NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F InChI=1S/C23H23F3N4O3S/c1-13-12-27-22(34-13)16-9-15(10-18(11-16)33-17-5-7-32-8-6-17)21(31)28-14(2)19-3-4-20(30-29-19)23(24,25)26/h3-4,9-12,14,17H,5-8H2,1-2H3,(H,28,31)/t14-/m1/s1 RJKHHNIHJKFMMR-CQSZACIVSA-N 319922 3-(5-Methyl- 1,3-thiazol-2- yl)-5- (tetrahydro- 2H-pyran-4- yloxy)-N- {(1R)-1-[6- (trifluoromethyl) pyridazin- 3-yl]ethyl} benzamide::US10174016, Example 89::US10202369, Example 89::US10472354, Example 89 P2X purinoceptor 3 Homo sapiens 11.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319922 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319922&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397595 384223202 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632174 CC[C@@H](NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H25F3N4O3S/c1-3-20(17-12-29-23(30-13-17)24(25,26)27)31-21(32)15-8-16(22-28-11-14(2)35-22)10-19(9-15)34-18-4-6-33-7-5-18/h8-13,18,20H,3-7H2,1-2H3,(H,31,32)/t20-/m1/s1 ULSBLOPPTNALIT-HXUWFJFHSA-N 319923 3-(5-Methyl- 1,3-thiazol-2- yl)-5- (tetrahydro- 2H-pyran-4- yloxy)-N-{(1R)- 1-[2- (trifluorometh- yl)pyrimidin-5- yl]propyl}benz- amide::US10174016, Example 90::US10202369, Example 90::US10472354, Example 90 P2X purinoceptor 3 Homo sapiens 111 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319923 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319923&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397769 384223203 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632176 C[C@@H](NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(C)s1)c1ccc(C)nc1 InChI=1S/C24H27N3O3S/c1-15-4-5-18(14-25-15)17(3)27-23(28)19-10-20(24-26-13-16(2)31-24)12-22(11-19)30-21-6-8-29-9-7-21/h4-5,10-14,17,21H,6-9H2,1-3H3,(H,27,28)/t17-/m1/s1 VKTBTGUHIBZLBJ-QGZVFWFLSA-N 319924 N-[(1R)-1-(6- Methylpyridin- 3-yl)ethyl]-3- (5-methyl-1,3- thiazol-2-yl)-5- (tetrahydro- 2H-pyran-4- yloxy)benzamide::US10174016, Example 91::US10202369, Example 91::US10472354, Example 91 P2X purinoceptor 3 Homo sapiens 19.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319924 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319924&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397502 384223204 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632178 C[C@@H](NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(C)s1)c1nnc(C)s1 InChI=1S/C21H24N4O3S2/c1-12-11-22-21(29-12)16-8-15(9-18(10-16)28-17-4-6-27-7-5-17)19(26)23-13(2)20-25-24-14(3)30-20/h8-11,13,17H,4-7H2,1-3H3,(H,23,26)/t13-/m1/s1 GHXRECQLMZGPIV-CYBMUJFWSA-N 319925 N-[(1R)-1-(5- Methyl-1,3,4- thiadiazol-2- yl)ethyl]-3-(5- methyl-1,3- thiazol-2-yl)-5- (tetrahydro- 2H-pyran-4- yloxy)benzamide::US10174016, Example 92::US10202369, Example 92::US10472354, Example 92 P2X purinoceptor 3 Homo sapiens 24.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319925 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319925&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397542 384223205 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632180 Cc1cnc(s1)-c1cc(OCC2CCOCC2)cc(c1)C(=O)NCc1ccc(C)nn1 InChI=1S/C23H26N4O3S/c1-15-3-4-20(27-26-15)13-24-22(28)18-9-19(23-25-12-16(2)31-23)11-21(10-18)30-14-17-5-7-29-8-6-17/h3-4,9-12,17H,5-8,13-14H2,1-2H3,(H,24,28) QOXIPNMWVVZPOQ-UHFFFAOYSA-N 319926 N-[(6- Methyl- pyridazin-3- yl)methyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5- (tetrahydro- 2H-pyran-4- ylmethoxy) benzamide::US10174016, Example 93::US10202369, Example 93::US10472354, Example 93 P2X purinoceptor 3 Homo sapiens 8.00 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319926 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319926&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397788 384223206 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632182 C[C@@H](NC(=O)c1cc(OCC2CCOCC2)cc(c1)-c1ncc(C)s1)c1cnc(C)cn1 InChI=1S/C24H28N4O3S/c1-15-11-26-22(13-25-15)17(3)28-23(29)19-8-20(24-27-12-16(2)32-24)10-21(9-19)31-14-18-4-6-30-7-5-18/h8-13,17-18H,4-7,14H2,1-3H3,(H,28,29)/t17-/m1/s1 HCAZTDIYUNBLAC-QGZVFWFLSA-N 319927 N-[(1R)-1-(5- Methylpyrazin- 2-yl)ethyl]- 3-(5-methyl- 1,3-thiazol-2- yl)-5- (tetrahydro- 2H-pyran-4- ylmethoxy) benzamide::US10174016, Example 94::US10202369, Example 94::US10472354, Example 94 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319927 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319927&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397604 384223207 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632184 CC(NC(=O)c1cc(OCC2CCOCC2)cc(c1)-c1ncc(C)s1)c1ncc(Cl)cc1F InChI=1S/C24H25ClFN3O3S/c1-14-11-28-24(33-14)18-7-17(8-20(9-18)32-13-16-3-5-31-6-4-16)23(30)29-15(2)22-21(26)10-19(25)12-27-22/h7-12,15-16H,3-6,13H2,1-2H3,(H,29,30) WLBXKEKEIMKGRV-UHFFFAOYSA-N 319928 N-[1-(5- Chloro-3- fluoropyridin- 2-yl)ethyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5- (tetrahydro- 2H-pyran--4- ylmethoxy) benzamide::US10174016, Example 95::US10202369, Example 95::US10472354, Example 95 P2X purinoceptor 3 Homo sapiens 2.00 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319928 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319928&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397656 384223208 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632186 CC(NC(=O)c1cc(OCC2CCOCC2)cc(c1)-c1ncc(C)s1)c1ncc(F)cc1Cl InChI=1S/C24H25ClFN3O3S/c1-14-11-28-24(33-14)18-7-17(8-20(9-18)32-13-16-3-5-31-6-4-16)23(30)29-15(2)22-21(25)10-19(26)12-27-22/h7-12,15-16H,3-6,13H2,1-2H3,(H,29,30) YAVBCOZWMZVERS-UHFFFAOYSA-N 319929 N-[1-(3- Chloro-5- fluoropyridin- 2-yl)ethyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5- (tetrahydro- 2H-pyran-4- ylmethoxy) benzamide::US10174016, Example 96::US10202369, Example 96::US10472354, Example 96 P2X purinoceptor 3 Homo sapiens 18.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319929 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319929&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397482 384223209 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632188 Cc1cnc(s1)-c1cc(OCC2CCOCC2)cc(c1)C(=O)NCc1cnc(C)cn1 InChI=1S/C23H26N4O3S/c1-15-10-25-20(12-24-15)13-26-22(28)18-7-19(23-27-11-16(2)31-23)9-21(8-18)30-14-17-3-5-29-6-4-17/h7-12,17H,3-6,13-14H2,1-2H3,(H,26,28) VSGRXICPAXTBHX-UHFFFAOYSA-N 319930 N-[(5- Methylpyrazin- 2- yl)methyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5- (tetrahydro- 2H-pyran-4- ylmethoxy) benzamide::US10174016, Example 97::US10202369, Example 97::US10472354, Example 97 P2X purinoceptor 3 Homo sapiens 15.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319930 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319930&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397814 384223210 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632190 C[C@@H](NC(=O)c1cc(OCC2CCOCC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H25F3N4O3S/c1-14-10-28-22(35-14)18-7-17(8-20(9-18)34-13-16-3-5-33-6-4-16)21(32)31-15(2)19-11-29-23(30-12-19)24(25,26)27/h7-12,15-16H,3-6,13H2,1-2H3,(H,31,32)/t15-/m1/s1 MBJQALPRFLKOPN-OAHLLOKOSA-N 319931 3-(5-Methyl- 1,3-thiazol-2- yl)-5- (tetrahydro- 2H-pyran-4- ylmethoxy)- N-[(1R)-1-[2- (trifluorometh- yl)pyrimidin- 5- yl]ethyl] benzamide::US10174016, Example 98::US10202369, Example 98::US10472354, Example 98 P2X purinoceptor 3 Homo sapiens 1.000 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319931 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319931&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397231 384223211 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632192 C[C@@H](NC(=O)c1cc(OCC2CCOCC2)cc(c1)-c1ncc(C)s1)c1ccc(C)nn1 InChI=1S/C24H28N4O3S/c1-15-4-5-22(28-27-15)17(3)26-23(29)19-10-20(24-25-13-16(2)32-24)12-21(11-19)31-14-18-6-8-30-9-7-18/h4-5,10-13,17-18H,6-9,14H2,1-3H3,(H,26,29)/t17-/m1/s1 FNFCPAXHCILJLE-QGZVFWFLSA-N 319932 N-[(1R)-1-(6- Methyl- pyridazin-3- yl)ethyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5- (tetrahydro- 2H-pyran-4- ylmethoxy) benzamide::US10174016, Example 99::US10202369, Example 99::US10472354, Example 99 P2X purinoceptor 3 Homo sapiens 2.00 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319932 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319932&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397399 384223212 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632194 C[C@@H](NC(=O)c1cc(Oc2ccnc(C)c2)cc(c1)-c1ncc(C)s1)c1ccc(C)nn1 InChI=1S/C24H23N5O2S/c1-14-5-6-22(29-28-14)17(4)27-23(30)18-10-19(24-26-13-16(3)32-24)12-21(11-18)31-20-7-8-25-15(2)9-20/h5-13,17H,1-4H3,(H,27,30)/t17-/m1/s1 AOJXRFXYSRJHEO-QGZVFWFLSA-N 319933 N-[(1R)-1-(6- Methyl- pyridazin-3- yl)ethyl]-3- [(2- methylpyridin- 4-yl)oxy]-5- (5-methyl- 1,3-thiazol-2- yl)benzamide::US10174016, Example 100::US10202369, Example 100::US10472354, Example 100 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319933 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319933&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397202 384223213 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625338 C[C@@H](NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C22H21F3N4O3S/c1-12-8-26-20(33-12)15-5-14(6-18(7-15)32-17-3-4-31-11-17)19(30)29-13(2)16-9-27-21(28-10-16)22(23,24)25/h5-10,13,17H,3-4,11H2,1-2H3,(H,29,30)/t13-,17+/m1/s1 GTQPEQGDLVSFJO-DYVFJYSZSA-N 319859 3-(5-Methyl-1,3-thiazol-2-yl)-5-[(3S)-tetrahydrofuran-3-yloxy]-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 26::US10202369, Example 26::US10472354, Example 26 P2X purinoceptor 3 Homo sapiens 8.00 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319859 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319859&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397418 384223139 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625340 C[C@@H](NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ccc(Cl)cn1 InChI=1S/C22H22ClN3O3S/c1-13-10-25-22(30-13)16-7-15(8-19(9-16)29-18-5-6-28-12-18)21(27)26-14(2)20-4-3-17(23)11-24-20/h3-4,7-11,14,18H,5-6,12H2,1-2H3,(H,26,27)/t14-,18+/m1/s1 DURBVTDNVKUTOV-KDOFPFPSSA-N 319860 N-[(1R)-1-(5-Chloropyridin-2-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(3S)-tetrahydrofuran-3-yloxy]benzamide::US10174016, Example 27::US10202369, Example 27::US10472354, Example 27 P2X purinoceptor 3 Homo sapiens 25.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319860 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319860&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397158 384223140 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625342 C[C@@H](NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ccc(C)cn1 InChI=1S/C23H25N3O3S/c1-14-4-5-21(24-11-14)16(3)26-22(27)17-8-18(23-25-12-15(2)30-23)10-20(9-17)29-19-6-7-28-13-19/h4-5,8-12,16,19H,6-7,13H2,1-3H3,(H,26,27)/t16-,19+/m1/s1 CFTQNAYGOFQJGD-APWZRJJASA-N 319861 N-[(1R)-1-(5-Methylpyridin-2-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(3S)-tetrahydrofuran-3-yloxy]benzamide::US10174016, Example 28::US10202369, Example 28::US10472354, Example 28 P2X purinoceptor 3 Homo sapiens 48.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319861 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319861&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397224 384223141 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625344 C[C@@H](NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1cnc(C)cn1 InChI=1S/C22H24N4O3S/c1-13-9-24-20(11-23-13)15(3)26-21(27)16-6-17(22-25-10-14(2)30-22)8-19(7-16)29-18-4-5-28-12-18/h6-11,15,18H,4-5,12H2,1-3H3,(H,26,27)/t15-,18+/m1/s1 GGLGXVJJVCGSBA-QAPCUYQASA-N 319862 N-[(1R)-1-(5-Methylpyrazin-2-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(3S)-tetrahydrofuran-3-yloxy]benzamide::US10174016, Example 29::US10472354, Example 29 P2X purinoceptor 3 Homo sapiens 79.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319862 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319862&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397726 384223142 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625346 C[C@@H](NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ccc(C)nc1 InChI=1S/C23H25N3O3S/c1-14-4-5-17(12-24-14)16(3)26-22(27)18-8-19(23-25-11-15(2)30-23)10-21(9-18)29-20-6-7-28-13-20/h4-5,8-12,16,20H,6-7,13H2,1-3H3,(H,26,27)/t16-,20+/m1/s1 KGDPEGCMVCXNPY-UZLBHIALSA-N 319863 N-[(1R)-1-(6- Methylpyridin- 3-yl)ethyl]-3- (5-methyl-1,3- thiazol-2-yl)-5- [(3S)- tetrahydrofuran- 3-yloxy] benzamide::US10174016, Example 30::US10202369, Example 30::US10472354, Example 30 P2X purinoceptor 3 Homo sapiens 38.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319863 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319863&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397828 384223143 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625348 Cc1cnc(s1)-c1cc(OCC#C)cc(c1)C(=O)NCc1ccc(C)nn1 InChI=1S/C20H18N4O2S/c1-4-7-26-18-9-15(8-16(10-18)20-22-11-14(3)27-20)19(25)21-12-17-6-5-13(2)23-24-17/h1,5-6,8-11H,7,12H2,2-3H3,(H,21,25) JDOBHPRLWOBCFP-UHFFFAOYSA-N 319864 N-[(6- Methylpyridazin- 3-yl)methyl]-3- (5-methyl-1,3- thiazol-2-yl)-5- (prop-2-yn-1- yloxy) benzamide::US10174016, Example 31::US10202369, Example 31::US10472354, Example 31 P2X purinoceptor 3 Homo sapiens 173 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319864 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319864&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397457 384223144 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625350 Cc1cnc(s1)-c1cc(OCC#C)cc(c1)C(=O)NCc1ncc(C)cc1F InChI=1S/C21H18FN3O2S/c1-4-5-27-17-8-15(7-16(9-17)21-25-11-14(3)28-21)20(26)24-12-19-18(22)6-13(2)10-23-19/h1,6-11H,5,12H2,2-3H3,(H,24,26) ISVVDRKQRYUMHL-UHFFFAOYSA-N 319865 N-[(5-Chloro- 3-fluoropyridin- 2-yl)methyl]- 3-(5-methyl- 1,3-thiazol-2- yl)-5-(prop-2- yn-1-yloxy) benzamide::US10174016, Example 32 P2X purinoceptor 3 Homo sapiens 24.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319865 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319865&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134463447 384223145 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625352 C[C@@H](NC(=O)c1cc(OCC#C)cc(c1)-c1ncc(C)s1)c1ccc(C)nc1 InChI=1S/C22H21N3O2S/c1-5-8-27-20-10-18(9-19(11-20)22-24-12-15(3)28-22)21(26)25-16(4)17-7-6-14(2)23-13-17/h1,6-7,9-13,16H,8H2,2-4H3,(H,25,26)/t16-/m1/s1 ZCHZUISZWKOUTB-MRXNPFEDSA-N 319866 N-[(1R)-1-(6- Methylpyridin- 3-yl)ethyl]-3- (5-methyl-1,3- thiazol-2-yl)-5- (prop-2-yn-1- yloxy) benzamide::US10174016, Example 33::US10202369, Example 33::US10472354, Example 33 P2X purinoceptor 3 Homo sapiens 29.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319866 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319866&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397790 384223146 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625354 C[C@@H](NC(=O)c1cc(OCC#C)cc(c1)-c1ncc(C)s1)c1cnc(C)cn1 InChI=1S/C21H20N4O2S/c1-5-6-27-18-8-16(7-17(9-18)21-24-11-14(3)28-21)20(26)25-15(4)19-12-22-13(2)10-23-19/h1,7-12,15H,6H2,2-4H3,(H,25,26)/t15-/m1/s1 UJLVWKMINNYJSM-OAHLLOKOSA-N 319867 N-[(1R)-1-(5- Methylpyrazin- 2-yl)ethyl]-3- (5-methyl-1,3- thiazol-2-yl)-5- (prop-2-yn-1- yloxy) benzamide::US10174016, Example 34::US10202369, Example 34::US10472354, Example 34 P2X purinoceptor 3 Homo sapiens 111 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319867 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319867&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397514 384223147 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625356 Cc1cnc(s1)-c1cc(OCC#C)cc(c1)C(=O)NCc1cnc(C)cn1 InChI=1S/C20H18N4O2S/c1-4-5-26-18-7-15(6-16(8-18)20-24-10-14(3)27-20)19(25)23-12-17-11-21-13(2)9-22-17/h1,6-11H,5,12H2,2-3H3,(H,23,25) HKQDCIZFKBUDQD-UHFFFAOYSA-N 319868 N-[(5- Methylpyrazin- 2-yl)methyl]- 3-(5-methyl- 1,3-thiazol-2- yl)-5-(prop-2- yn-1- yloxy)benzamide::US10174016, Example 35::US10202369, Example 35::US10472354, Example 35 P2X purinoceptor 3 Homo sapiens 460 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319868 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319868&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397704 384223148 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625358 C[C@@H](NC(=O)c1cc(OCC#C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C21H17F3N4O2S/c1-4-5-30-17-7-14(6-15(8-17)19-25-9-12(2)31-19)18(29)28-13(3)16-10-26-20(27-11-16)21(22,23)24/h1,6-11,13H,5H2,2-3H3,(H,28,29)/t13-/m1/s1 BTRSFHCVZJPJKT-CYBMUJFWSA-N 319869 3-(5-Methyl- 1,3-thiazol-2- yl)-5-(prop-2- yn-1-yloxy)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 36::US10202369, Example 36::US10472354, Example 36 P2X purinoceptor 3 Homo sapiens 14.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319869 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319869&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397309 384223149 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625360 C[C@@H](NC(=O)c1cc(OCC#C)cc(c1)-c1ncc(C)s1)c1ccc(C)nn1 InChI=1S/C21H20N4O2S/c1-5-8-27-18-10-16(9-17(11-18)21-22-12-14(3)28-21)20(26)23-15(4)19-7-6-13(2)24-25-19/h1,6-7,9-12,15H,8H2,2-4H3,(H,23,26)/t15-/m1/s1 IZIUFNSLLIEWJE-OAHLLOKOSA-N 319870 N-[(1R)-1-(6- Methylpyridazin- 3-yl)ethyl]- 3-(5-methyl- 1,3-thiazol-2- yl)-5-(prop-2- yn-1- yloxy) benzamide::US10174016, Example 37::US10202369, Example 37::US10472354, Example 37 P2X purinoceptor 3 Homo sapiens 55.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319870 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319870&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397261 384223150 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625362 C[C@@H](NC(=O)c1cc(OCC#C)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F InChI=1S/C21H17F3N4O2S/c1-4-7-30-16-9-14(8-15(10-16)20-25-11-12(2)31-20)19(29)26-13(3)17-5-6-18(28-27-17)21(22,23)24/h1,5-6,8-11,13H,7H2,2-3H3,(H,26,29)/t13-/m1/s1 PNZFOFJAUOCDQW-CYBMUJFWSA-N 319871 3-(5-Methyl- 1,3-thiazol-2- yl)-5-(prop-2- yn-1-yloxy)-N- [(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl] benzamide::US10174016, Example 38::US10202369, Example 38::US10472354, Example 38 P2X purinoceptor 3 Homo sapiens 55.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319871 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319871&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397333 384223151 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625364 C[C@@H](NC(=O)c1cc(OCC#C)cc(c1)-c1ncc(C)s1)c1cnc(C)nc1 InChI=1S/C21H20N4O2S/c1-5-6-27-19-8-16(7-17(9-19)21-24-10-13(2)28-21)20(26)25-14(3)18-11-22-15(4)23-12-18/h1,7-12,14H,6H2,2-4H3,(H,25,26)/t14-/m1/s1 OVENJFXCZONLOP-CQSZACIVSA-N 319872 N-[(1R)-1-(2- Methylpyrimidin- 5-yl)ethyl]- 3-(5-methyl- 1,3-thiazol-2- yl)-5-(prop-2- yn-1- yloxy) benzamide::US10174016, Example 39::US10202369, Example 39::US10472354, Example 39 P2X purinoceptor 3 Homo sapiens 81.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319872 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319872&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397588 384223152 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625366 CC#CCOc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C22H19F3N4O2S/c1-4-5-6-31-18-8-15(7-16(9-18)20-26-10-13(2)32-20)19(30)29-14(3)17-11-27-21(28-12-17)22(23,24)25/h7-12,14H,6H2,1-3H3,(H,29,30)/t14-/m1/s1 XSZOYFWYESZINQ-CQSZACIVSA-N 319873 3-(But-2-yn-1- yloxy)-5-(5- methyl-1,3- thiazol-2-yl)- N-[(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl] benzamide::US10174016, Example 40::US10202369, Example 40::US10472354, Example 40 P2X purinoceptor 3 Homo sapiens 16.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319873 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319873&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397357 384223153 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625368 CC#CCOc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1nnc(C)s1 InChI=1S/C20H20N4O2S2/c1-5-6-7-26-17-9-15(8-16(10-17)20-21-11-12(2)27-20)18(25)22-13(3)19-24-23-14(4)28-19/h8-11,13H,7H2,1-4H3,(H,22,25)/t13-/m1/s1 ORWZAOZYNYEGDS-CYBMUJFWSA-N 319874 3-(But-2-yn-1- yloxy)-N-[(1R)- 1-(5-methyl- 1,3,4- thiadiazol-2- yl)ethyl]-5-(5- methyl-1,3- thiazol-2- yl)benzamide::US10174016, Example 41::US10202369, Example 41::US10472354, Example 41 P2X purinoceptor 3 Homo sapiens 130 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319874 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319874&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397286 384223154 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625370 C[C@@H](NC(=O)c1cc(OC2COC2)cc(c1)-c1ncc(C)s1)c1cnc(C)cn1 InChI=1S/C21H22N4O3S/c1-12-7-23-19(9-22-12)14(3)25-20(26)15-4-16(21-24-8-13(2)29-21)6-17(5-15)28-18-10-27-11-18/h4-9,14,18H,10-11H2,1-3H3,(H,25,26)/t14-/m1/s1 AWWAAAATSKEOQH-CQSZACIVSA-N 319875 N-[(1R)-1-(5-Methylpyrazin-2-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-(oxetan-3-yloxy)benzamide::US10174016, Example 42::US10202369, Example 42::US10472354, Example 42 P2X purinoceptor 3 Homo sapiens 129 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319875 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319875&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397394 384223155 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625372 C[C@@H](NC(=O)c1cc(OC2COC2)cc(c1)-c1ncc(C)s1)c1cnc(C)nc1 InChI=1S/C21H22N4O3S/c1-12-7-24-21(29-12)16-4-15(5-18(6-16)28-19-10-27-11-19)20(26)25-13(2)17-8-22-14(3)23-9-17/h4-9,13,19H,10-11H2,1-3H3,(H,25,26)/t13-/m1/s1 QZYMXYIOESSIBG-CYBMUJFWSA-N 319876 N-[(1R)-1-(2-Methylpyrimidin-5-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-(oxetan-3-yloxy)benzamide::US10174016, Example 43::US10202369, Example 43::US10472354, Example 43 P2X purinoceptor 3 Homo sapiens 50.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319876 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319876&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397750 384223156 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625374 CC(NC(=O)c1cc(OC2COC2)cc(c1)-c1ncc(C)s1)c1ncc(Cl)cc1F InChI=1S/C21H19ClFN3O3S/c1-11-7-25-21(30-11)14-3-13(4-16(5-14)29-17-9-28-10-17)20(27)26-12(2)19-18(23)6-15(22)8-24-19/h3-8,12,17H,9-10H2,1-2H3,(H,26,27) DXVSMJSLGFWBSV-UHFFFAOYSA-N 319877 N-[1-(5-Chloro-3-fluoropyridin-2-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-(oxetan-3-yloxy)benzamide::US10174016, Example 44::US10202369, Example 44::US10472354, Example 44 P2X purinoceptor 3 Homo sapiens 11.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319877 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319877&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397182 384223157 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625376 Cc1cnc(s1)-c1cc(OC2COC2)cc(c1)C(=O)NCc1ccc(C)nn1 InChI=1S/C20H20N4O3S/c1-12-3-4-16(24-23-12)9-21-19(25)14-5-15(20-22-8-13(2)28-20)7-17(6-14)27-18-10-26-11-18/h3-8,18H,9-11H2,1-2H3,(H,21,25) AFIPEIBYSBBLBJ-UHFFFAOYSA-N 319878 N-[(6-Methylpyridazin-3-yl)methyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-(oxetan-3-yloxy)benzamide::US10174016, Example 45::US10202369, Example 45::US10472354, Example 45 P2X purinoceptor 3 Homo sapiens 212 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319878 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319878&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397740 384223158 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625378 C[C@@H](NC(=O)c1cc(OC2COC2)cc(c1)-c1ncc(C)s1)c1ccc(Cl)cn1 InChI=1S/C21H20ClN3O3S/c1-12-8-24-21(29-12)15-5-14(6-17(7-15)28-18-10-27-11-18)20(26)25-13(2)19-4-3-16(22)9-23-19/h3-9,13,18H,10-11H2,1-2H3,(H,25,26)/t13-/m1/s1 FFCGGIUVAQWIMW-CYBMUJFWSA-N 319879 N-[(1R)-1-(5-Chloropyridin-2-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-(oxetan-3-yloxy)benzamide::US10174016, Example 46::US10202369, Example 46::US10472354, Example 46 P2X purinoceptor 3 Homo sapiens 10.00 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319879 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319879&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397660 384223159 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625380 C[C@@H](NC(=O)c1cc(OC2COC2)cc(c1)-c1ncc(C)s1)c1ccc(C)nn1 InChI=1S/C21H22N4O3S/c1-12-4-5-19(25-24-12)14(3)23-20(26)15-6-16(21-22-9-13(2)29-21)8-17(7-15)28-18-10-27-11-18/h4-9,14,18H,10-11H2,1-3H3,(H,23,26)/t14-/m1/s1 HFDOVXXFUCEVBK-CQSZACIVSA-N 319880 N-[(1R)-1-(6-Methylpyridazin-3-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-(oxetan-3-yloxy)benzamide::US10174016, Example 47::US10202369, Example 47::US10472354, Example 47 P2X purinoceptor 3 Homo sapiens 82.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319880&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397352 384223160 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625382 C[C@@H](NC(=O)c1cc(OC2COC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C21H19F3N4O3S/c1-11-6-25-19(32-11)14-3-13(4-16(5-14)31-17-9-30-10-17)18(29)28-12(2)15-7-26-20(27-8-15)21(22,23)24/h3-8,12,17H,9-10H2,1-2H3,(H,28,29)/t12-/m1/s1 HXNSKECKPLVRIH-GFCCVEGCSA-N 319881 3-(5-Methyl-1,3-thiazol-2-yl)-5-(oxetan-3-yloxy)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 48::US10202369, Example 48::US10472354, Example 48 P2X purinoceptor 3 Homo sapiens 14.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319881 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319881&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397291 384223161 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625384 CC(NC(=O)c1cc(OC2COC2)cc(c1)-c1ncc(C)s1)c1ncc(F)cc1Cl InChI=1S/C21H19ClFN3O3S/c1-11-7-25-21(30-11)14-3-13(4-16(5-14)29-17-9-28-10-17)20(27)26-12(2)19-18(22)6-15(23)8-24-19/h3-8,12,17H,9-10H2,1-2H3,(H,26,27) FNMVOFQACWEVTO-UHFFFAOYSA-N 319882 N-[1-(3-Chloro-5-fluoropyridin-2-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-(oxetan-3-yloxy)benzamide::US10174016, Example 49::US10202369, Example 49::US10472354, Example 49 P2X purinoceptor 3 Homo sapiens 132 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319882 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319882&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397320 384223162 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625386 C[C@@H](NC(=O)c1cc(OC2COC2)cc(c1)-c1ncc(C)s1)c1nnc(C)s1 InChI=1S/C19H20N4O3S2/c1-10-7-20-19(27-10)14-4-13(5-15(6-14)26-16-8-25-9-16)17(24)21-11(2)18-23-22-12(3)28-18/h4-7,11,16H,8-9H2,1-3H3,(H,21,24)/t11-/m1/s1 RQBQZBLVECLWLL-LLVKDONJSA-N 319883 N-[(1R)-1-(5-Methyl-1,3,4-thiadiazol-2-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-(oxetan-3-yloxy)benzamide::US10174016, Example 50::US10202369, Example 50 P2X purinoceptor 3 Homo sapiens 77.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319883 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319883&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397179 384223163 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625388 C[C@@H](NC(=O)c1cc(OC2COC2)cc(c1)-c1ncc(C)s1)c1ccc(C)nc1 InChI=1S/C22H23N3O3S/c1-13-4-5-16(10-23-13)15(3)25-21(26)17-6-18(22-24-9-14(2)29-22)8-19(7-17)28-20-11-27-12-20/h4-10,15,20H,11-12H2,1-3H3,(H,25,26)/t15-/m1/s1 MHQNYPHPPSGTBD-OAHLLOKOSA-N 319884 N-[(1R)-1-(6-methylpyridin-3-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-(oxetan-3-yloxy)benzamide::US10174016, Example 51::US10202369, Example 51 P2X purinoceptor 3 Homo sapiens 74.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319884 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319884&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397804 384223164 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625390 Cc1cnc(s1)-c1cc(OC2COC2)cc(c1)C(=O)NCc1ccc(nn1)C(F)(F)F InChI=1S/C20H17F3N4O3S/c1-11-7-25-19(31-11)13-4-12(5-15(6-13)30-16-9-29-10-16)18(28)24-8-14-2-3-17(27-26-14)20(21,22)23/h2-7,16H,8-10H2,1H3,(H,24,28) KTKYNBLLOZOZPY-UHFFFAOYSA-N 319885 3-(5-Methyl- 1,3-thiazol-2- yl)-5-(oxetan- 3-yloxy)-N-{[6- (trifluoromethyl) pyridazin-3- yl]methyl} benzamide::US10174016, Example 52::US10202369, Example 52::US10472354, Example 52 P2X purinoceptor 3 Homo sapiens 194 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319885 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319885&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397650 384223165 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625392 CC[C@@H](NC(=O)c1cc(OC2COC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C22H21F3N4O3S/c1-3-18(15-8-27-21(28-9-15)22(23,24)25)29-19(30)13-4-14(20-26-7-12(2)33-20)6-16(5-13)32-17-10-31-11-17/h4-9,17-18H,3,10-11H2,1-2H3,(H,29,30)/t18-/m1/s1 PHCWFMJDVHAVQT-GOSISDBHSA-N 319886 3-(5-Methyl- 1,3-thiazol-2- yl)-5-(oxetan- 3-yloxy)-N- [(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]propyl] benzamide::US10174016, Example 53::US10202369, Example 53::US10472354, Example 53 P2X purinoceptor 3 Homo sapiens 318 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319886 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319886&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397526 384223166 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625394 Cc1cnc(s1)-c1cc(OC[C@@H]2CCCO2)cc(c1)C(=O)NCc1ccc(C)nn1 InChI=1S/C22H24N4O3S/c1-14-5-6-18(26-25-14)12-23-21(27)16-8-17(22-24-11-15(2)30-22)10-20(9-16)29-13-19-4-3-7-28-19/h5-6,8-11,19H,3-4,7,12-13H2,1-2H3,(H,23,27)/t19-/m0/s1 IFCRFQDQDLUKDL-IBGZPJMESA-N 319887 N-[(6-Methylpyridazin-3-yl)methyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(2S)-tetrahydrofuran-2-ylmethoxy]benzamide::US10174016, Example 54::US10202369, Example 54::US10472354, Example 54 P2X purinoceptor 3 Homo sapiens 66.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319887 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319887&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397485 384223167 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625396 Cc1cnc(s1)-c1cc(OCC2CCCO2)cc(c1)C(=O)NCc1ncc(Cl)cc1F InChI=1S/C22H21ClFN3O3S/c1-13-9-27-22(31-13)15-5-14(6-18(7-15)30-12-17-3-2-4-29-17)21(28)26-11-20-19(24)8-16(23)10-25-20/h5-10,17H,2-4,11-12H2,1H3,(H,26,28) UTQWAUZOCBGCBP-UHFFFAOYSA-N 319888 N-[(5-Chloro-3-fluoropyridin-2-yl)methyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(2S)-tetrahydrofuran-2-ylmethoxy]benzamide::US10174016, Example 55 P2X purinoceptor 3 Homo sapiens 8.00 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319888 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319888&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134463449 384223168 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625398 Cc1cnc(s1)-c1cc(OC[C@@H]2CCCO2)cc(c1)C(=O)NCc1cnc(C)cn1 InChI=1S/C22H24N4O3S/c1-14-9-24-18(11-23-14)12-25-21(27)16-6-17(22-26-10-15(2)30-22)8-20(7-16)29-13-19-4-3-5-28-19/h6-11,19H,3-5,12-13H2,1-2H3,(H,25,27)/t19-/m0/s1 UMCJOKLDVAQWOA-IBGZPJMESA-N 319889 N-[(5-Methylpyrazin-2-yl)methyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(2S)-tetrahydrofuran-2-ylmethoxy]benzamide::US10174016, Example 56::US10202369, Example 56 P2X purinoceptor 3 Homo sapiens 148 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319889 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319889&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397398 384223169 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632258 CC(NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ncc(F)cc1Cl InChI=1S/C22H21ClFN3O3S/c1-12-9-26-22(31-12)15-5-14(6-18(7-15)30-17-3-4-29-11-17)21(28)27-13(2)20-19(23)8-16(24)10-25-20/h5-10,13,17H,3-4,11H2,1-2H3,(H,27,28)/t13?,17-/m0/s1 YETTUNLUNMEXML-RUINGEJQSA-N 319965 N-[1-(3-Chloro-5-fluoropyridin-2-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(3S)-tetrahydrofuran-3-yloxy]benzamide::US10174016, Example 132::US10202369, Example 132::US10472354, Example 132 P2X purinoceptor 3 Homo sapiens 75.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319965 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319965&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397504 384223245 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632260 Cc1cnc(s1)-c1cc(O[C@H]2CCOC2)cc(c1)C(=O)NCc1ccc(C)nn1 InChI=1S/C21H22N4O3S/c1-13-3-4-17(25-24-13)11-22-20(26)15-7-16(21-23-10-14(2)29-21)9-19(8-15)28-18-5-6-27-12-18/h3-4,7-10,18H,5-6,11-12H2,1-2H3,(H,22,26)/t18-/m0/s1 VKRRMZCTKMLCQJ-SFHVURJKSA-N 319966 N-[(6-Methylpyridazin-3-yl)methyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(3S)-tetrahydrofuran-3-yloxy]benzamide::US10174016, Example 133::US10202369, Example 133::US10472354, Example 133 P2X purinoceptor 3 Homo sapiens 177 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319966 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319966&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397536 384223246 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632262 CC(NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ncc(Cl)cc1F InChI=1S/C22H21ClFN3O3S/c1-12-9-26-22(31-12)15-5-14(6-18(7-15)30-17-3-4-29-11-17)21(28)27-13(2)20-19(24)8-16(23)10-25-20/h5-10,13,17H,3-4,11H2,1-2H3,(H,27,28)/t13?,17-/m0/s1 DLODQDUFIVUCLQ-RUINGEJQSA-N 319967 N-[1-(5-Chloro-3-fluoropyridin-2-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(3S)-tetrahydrofuran-3-yloxy]benzamide::US10174016, Example 134::US10202369, Example 134::US10472354, Example 134 P2X purinoceptor 3 Homo sapiens 15.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319967 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319967&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397151 384223247 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632264 C[C@@H](NC(=O)c1cc(OC[C@H]2CCOC2)cc(c1)-c1ncc(s1)C1CCC1)c1ccc(C)nn1 InChI=1S/C26H30N4O3S/c1-16-6-7-23(30-29-16)17(2)28-25(31)20-10-21(26-27-13-24(34-26)19-4-3-5-19)12-22(11-20)33-15-18-8-9-32-14-18/h6-7,10-13,17-19H,3-5,8-9,14-15H2,1-2H3,(H,28,31)/t17-,18+/m1/s1 KRMAXJMLJAVOGJ-MSOLQXFVSA-N 319968 3-(5-Cyclobutyl-1,3-thiazol-2-yl)-N-[(1R)-1-(6-methylpyridazin-3-yl)ethyl]-5-[(3S)-tetrahydrofuran-3-ylmethoxy]benzamide::US10174016, Example 135::US10202369, Example 135::US10472354, Example 270 P2X purinoceptor 3 Homo sapiens 35.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319968 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319968&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397422 384223248 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632266 COCCOc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1cnc(C)nc1 InChI=1S/C21H24N4O3S/c1-13-10-24-21(29-13)17-7-16(8-19(9-17)28-6-5-27-4)20(26)25-14(2)18-11-22-15(3)23-12-18/h7-12,14H,5-6H2,1-4H3,(H,25,26)/t14-/m1/s1 NMXUVEDIBFBQMK-CQSZACIVSA-N 319969 3-(2-Methoxyethoxy)-N-[(1R)-1-(2-methylpyrimidin-5-yl)ethyl]-5-(5-methyl-1,3-thiazol-2-yl)benzamide::US10174016, Example 136::US10202369, Example 136::US10472354, Example 136 P2X purinoceptor 3 Homo sapiens 196 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319969 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319969&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397574 384223249 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632268 C[C@@H](NC(=O)c1cc(OC2CCN(CC2)C(=O)OC(C)(C)C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C28H32F3N5O4S/c1-16-13-32-24(41-16)19-10-18(23(37)35-17(2)20-14-33-25(34-15-20)28(29,30)31)11-22(12-19)39-21-6-8-36(9-7-21)26(38)40-27(3,4)5/h10-15,17,21H,6-9H2,1-5H3,(H,35,37)/t17-/m1/s1 FLJTWWMLFZUWSL-QGZVFWFLSA-N 319970 US10174016, Example 137::US10472354, Example 137::tert-Butyl 4-[3-(5-methyl-1,3-thiazol-2-yl)-5-({(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}carbamoyl)phenoxy]piperidine-1-carboxylate P2X purinoceptor 3 Homo sapiens 26.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319970 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319970&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397466 384223250 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632270 C[C@@H](NC(=O)c1cc(OC2CCNCC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H24F3N5O2S/c1-13-10-28-21(34-13)16-7-15(8-19(9-16)33-18-3-5-27-6-4-18)20(32)31-14(2)17-11-29-22(30-12-17)23(24,25)26/h7-12,14,18,27H,3-6H2,1-2H3,(H,31,32)/t14-/m1/s1 AUEVADIQWKJNQT-CQSZACIVSA-N 319971 3-(5-Methyl-1,3-thiazol-2-yl)-5-(piperidin-4-yloxy)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 138::US10202369, Example 138::US10472354, Example 138 P2X purinoceptor 3 Homo sapiens 11.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319971 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319971&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397389 384223251 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632272 C[C@@H](NC(=O)c1cc(OC2CCN(C)CC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H26F3N5O2S/c1-14-11-28-22(35-14)17-8-16(9-20(10-17)34-19-4-6-32(3)7-5-19)21(33)31-15(2)18-12-29-23(30-13-18)24(25,26)27/h8-13,15,19H,4-7H2,1-3H3,(H,31,33)/t15-/m1/s1 BKNIRTNEYAOJDL-OAHLLOKOSA-N 319972 3-[(1-Methylpiperidin-4-yl)oxy]-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 139::US10202369, Example 139::US10472354, Example 215 P2X purinoceptor 3 Homo sapiens 8.00 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319972 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319972&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397521 384223252 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632274 CC(C)N1CCC(CC1)Oc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C26H30F3N5O2S/c1-15(2)34-7-5-21(6-8-34)36-22-10-18(9-19(11-22)24-30-12-16(3)37-24)23(35)33-17(4)20-13-31-25(32-14-20)26(27,28)29/h9-15,17,21H,5-8H2,1-4H3,(H,33,35)/t17-/m1/s1 JAJQPYKLEVBCIY-QGZVFWFLSA-N 319973 3-(5-Methyl-1,3-thiazol-2-yl)-5-{[1-(propan-2-yl)piperidin-4-yl]oxy}-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 140::US10202369, Example 140::US10472354, Example 140 P2X purinoceptor 3 Homo sapiens 33.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319973 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319973&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397336 384223253 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632276 C[C@@H](NC(=O)c1cc(O[C@@H]2CCN(C)C2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H24F3N5O2S/c1-13-9-27-21(34-13)16-6-15(7-19(8-16)33-18-4-5-31(3)12-18)20(32)30-14(2)17-10-28-22(29-11-17)23(24,25)26/h6-11,14,18H,4-5,12H2,1-3H3,(H,30,32)/t14-,18-/m1/s1 RNHSPVKPEXJLAD-RDTXWAMCSA-N 319974 3-{[(3R)-1-Methylpyrrolidin-3-yl]oxy}-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 141::US10202369, Example 141::US10472354, Example 141 P2X purinoceptor 3 Homo sapiens 43.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319974 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319974&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397272 384223254 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632278 C[C@@H](NC(=O)c1cc(O[C@H]2CCN(C)C2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H24F3N5O2S/c1-13-9-27-21(34-13)16-6-15(7-19(8-16)33-18-4-5-31(3)12-18)20(32)30-14(2)17-10-28-22(29-11-17)23(24,25)26/h6-11,14,18H,4-5,12H2,1-3H3,(H,30,32)/t14-,18+/m1/s1 RNHSPVKPEXJLAD-KDOFPFPSSA-N 319975 3-{[(3S)-1-Methylpyrrolidin-3-yl]oxy}-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 142::US10202369, Example 142::US10472354, Example 142 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319975 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319975&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397181 384223255 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632280 C[C@@H](NC(=O)c1cc(OC2CN(C)C2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C22H22F3N5O2S/c1-12-7-26-20(33-12)15-4-14(5-17(6-15)32-18-10-30(3)11-18)19(31)29-13(2)16-8-27-21(28-9-16)22(23,24)25/h4-9,13,18H,10-11H2,1-3H3,(H,29,31)/t13-/m1/s1 NFRXFSQBXDHWHW-CYBMUJFWSA-N 319976 3-[(1-Methylazetidin-3-yl)oxy]-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 143::US10202369, Example 143::US10472354, Example 143 P2X purinoceptor 3 Homo sapiens 84.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319976 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319976&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397519 384223256 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632282 C[C@H](NC(=O)c1cc(OCC#C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C21H17F3N4O2S/c1-4-5-30-17-7-14(6-15(8-17)19-25-9-12(2)31-19)18(29)28-13(3)16-10-26-20(27-11-16)21(22,23)24/h1,6-11,13H,5H2,2-3H3,(H,28,29)/t13-/m0/s1 BTRSFHCVZJPJKT-ZDUSSCGKSA-N 319977 3-(5-Methyl-1,3-thiazol-2-yl)-5-(prop-2-yn-1-yloxy)-N-{(1S)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 144::US10202369, Example 144::US10472354, Example 144 P2X purinoceptor 3 Homo sapiens 825 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319977 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319977&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397460 384223257 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632284 C[C@H](NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H23F3N4O3S/c1-13-10-27-21(34-13)16-7-15(8-19(9-16)33-18-3-5-32-6-4-18)20(31)30-14(2)17-11-28-22(29-12-17)23(24,25)26/h7-12,14,18H,3-6H2,1-2H3,(H,30,31)/t14-/m0/s1 WGQQHPGXKFPPTQ-AWEZNQCLSA-N 319978 3-(5-Methyl-1,3-thiazol-2-yl)-5-(tetrahydro-2H-pyran-4-yloxy)-N-{(1S)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 145::US10202369, Example 145::US10472354, Example 145 P2X purinoceptor 3 Homo sapiens 271 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319978 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319978&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397306 384223258 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632286 C[C@@H](NC(=O)c1cc(OC2CC3(C2)CN(C3)C(=O)OC(C)(C)C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C29H32F3N5O4S/c1-16-11-33-24(42-16)19-6-18(23(38)36-17(2)20-12-34-25(35-13-20)29(30,31)32)7-21(8-19)40-22-9-28(10-22)14-37(15-28)26(39)41-27(3,4)5/h6-8,11-13,17,22H,9-10,14-15H2,1-5H3,(H,36,38)/t17-/m1/s1 GOFUMWOIVIXXIJ-QGZVFWFLSA-N 319979 US10174016, Example 146::US10202369, Example 146::US10472354, Example 146::tert-butyl 6-[3-(5- methyl-1,3- thiazol-2-yl)-5- ({(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}carbamoyl) phenoxy]-2- azaspiro[3.3]heptane- 2-carboxylate P2X purinoceptor 3 Homo sapiens 45.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319979 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319979&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397340 384223259 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632288 C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1cnc(cn1)C(F)(F)F InChI=1S/C22H21F3N4O3S/c1-12-8-28-21(33-12)15-5-14(6-17(7-15)32-16-3-4-31-11-16)20(30)29-13(2)18-9-27-19(10-26-18)22(23,24)25/h5-10,13,16H,3-4,11H2,1-2H3,(H,29,30)/t13-,16-/m1/s1 DVMONFUPUPPMFW-CZUORRHYSA-N 319980 3-(5-methyl-1,3- thiazol-2-yl)-5- [(3R)- tetrahydrofuran-3- yloxy]-N-{(1R)-1- [5- (trifluoromethyl) pyrazin-2- yl]ethyl}benzamide::US10174016, Example 147::US10202369, Example 147::US10472354, Example 147 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319980 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319980&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397189 384223260 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632290 C[C@@H](NC(=O)c1cc(OC2COC2)cc(c1)-c1ncc(C)s1)c1ccc(nc1)C(F)(F)F InChI=1S/C22H20F3N3O3S/c1-12-8-27-21(32-12)16-5-15(6-17(7-16)31-18-10-30-11-18)20(29)28-13(2)14-3-4-19(26-9-14)22(23,24)25/h3-9,13,18H,10-11H2,1-2H3,(H,28,29)/t13-/m1/s1 NAXHTXVAPBZYNR-CYBMUJFWSA-N 319981 3-(5-methyl-1,3- thiazol-2-yl)-5- (oxetan-3-yloxy)- N-{(1R)-1-[6- (trifluoromethyl) pyridin-3- yl]ethyl}benzamide::US10174016, Example 148::US10202369, Example 148::US10472354, Example 148 P2X purinoceptor 3 Homo sapiens 33.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319981 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319981&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397138 384223261 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632292 C[C@@H](NC(=O)c1cc(OC23CCN(CC2)CC3)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C25H26F3N5O2S/c1-15-12-29-22(36-15)18-9-17(10-20(11-18)35-24-3-6-33(7-4-24)8-5-24)21(34)32-16(2)19-13-30-23(31-14-19)25(26,27)28/h9-14,16H,3-8H2,1-2H3,(H,32,34)/t16-/m1/s1 RAGSAJSSGMANHP-MRXNPFEDSA-N 319982 3-(1- azabicyclo[2.2.2] oct-4-yloxy)-5-(5- methyl-1,3- thiazol-3-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 149::US10202369, Example 149::US10472354, Example 149 P2X purinoceptor 3 Homo sapiens 21.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319982 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319982&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397715 384223262 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632294 C[C@@H](NC(=O)c1cc(OC2CCN(CC2)C(C)=O)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C25H26F3N5O3S/c1-14-11-29-23(37-14)18-8-17(9-21(10-18)36-20-4-6-33(7-5-20)16(3)34)22(35)32-15(2)19-12-30-24(31-13-19)25(26,27)28/h8-13,15,20H,4-7H2,1-3H3,(H,32,35)/t15-/m1/s1 ISMQQTCWBNBFKY-OAHLLOKOSA-N 319983 3-[(1- acetylpiperidin-4- yl)oxy]-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 150::US10202369, Example 150::US10472354, Example 150 P2X purinoceptor 3 Homo sapiens 12.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319983 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319983&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397215 384223263 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632296 C[C@@H](NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)F InChI=1S/C22H22F2N4O3S/c1-12-8-27-22(32-12)15-5-14(6-18(7-15)31-17-3-4-30-11-17)21(29)28-13(2)16-9-25-20(19(23)24)26-10-16/h5-10,13,17,19H,3-4,11H2,1-2H3,(H,28,29)/t13-,17+/m1/s1 AUVRCFBFFFYNAV-DYVFJYSZSA-N 319984 N-{(1R)-1-[2- (difluoromethyl) pyrimidin-5- yl]ethyl}-3-(5- methyl-1,3- thiazol-2-yl)-5- [(3S)- tetrahydrofuran-3- yloxy]benzamide::US10174016, Example 151::US10202369, Example 151::US10472354, Example 151 P2X purinoceptor 3 Homo sapiens 31.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319984 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319984&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397480 384223264 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632298 C[C@@H](NC(=O)c1cc(OC2COC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)F InChI=1S/C21H20F2N4O3S/c1-11-6-26-21(31-11)14-3-13(4-16(5-14)30-17-9-29-10-17)20(28)27-12(2)15-7-24-19(18(22)23)25-8-15/h3-8,12,17-18H,9-10H2,1-2H3,(H,27,28)/t12-/m1/s1 YTKWIWSPGJOVJL-GFCCVEGCSA-N 319985 N-{(1R)-1-[2- (difluoromethyl) pyrimidin-5- yl]ethyl}-3-(5- methyl-1,3- thiazol-2-yl)-5- (oxetan-3- yloxy)benzamide::US10174016, Example 152::US10202369, Example 152::US10472354, Example 152 P2X purinoceptor 3 Homo sapiens 45.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319985 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319985&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397528 384223265 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632300 C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)F InChI=1S/C22H22F2N4O3S/c1-12-8-27-22(32-12)15-5-14(6-18(7-15)31-17-3-4-30-11-17)21(29)28-13(2)16-9-25-20(19(23)24)26-10-16/h5-10,13,17,19H,3-4,11H2,1-2H3,(H,28,29)/t13-,17-/m1/s1 AUVRCFBFFFYNAV-CXAGYDPISA-N 319986 N-{(1R)-1-[2- (difluoromethyl) pyrimidin-5- yl]ethyl}-3-(5- methyl-1,3- thiazol-2-yl)-5- [(3R)- tetrahydrofuran-3- yloxy]benzamide::US10174016, Example 153::US10202369, Example 153::US10472354, Example 153 P2X purinoceptor 3 Homo sapiens 27.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319986 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319986&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397665 384223266 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632302 C[C@@H](NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)F InChI=1S/C23H24F2N4O3S/c1-13-10-28-23(33-13)16-7-15(8-19(9-16)32-18-3-5-31-6-4-18)22(30)29-14(2)17-11-26-21(20(24)25)27-12-17/h7-12,14,18,20H,3-6H2,1-2H3,(H,29,30)/t14-/m1/s1 RQWRZCMIWXGQJP-CQSZACIVSA-N 319987 N-{(1R)-1-[2- (difluoromethyl) pyrimidin-5- yl]ethyl}-3-(5- methyl-1,3- thiazol-2-yl)-5- (tetrahydro-2H- pyran-4- yloxy)benzamide::US10174016, Example 154::US10202369, Example 154::US10472354, Example 154 P2X purinoceptor 3 Homo sapiens 18.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319987 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319987&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397560 384223267 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632304 C[C@@H](NC(=O)c1cc(O[C@H]2CCCN(C)C2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H26F3N5O2S/c1-14-10-28-22(35-14)17-7-16(8-20(9-17)34-19-5-4-6-32(3)13-19)21(33)31-15(2)18-11-29-23(30-12-18)24(25,26)27/h7-12,15,19H,4-6,13H2,1-3H3,(H,31,33)/t15-,19+/m1/s1 DNVWWBHMIGZIMX-BEFAXECRSA-N 319988 3-{[(3S)-1- methylpiperidin-3- yl]oxy}-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 155::US10174016, Example 221::US10202369, Example 155::US10472354, Example 155 P2X purinoceptor 3 Homo sapiens 40.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319988 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319988&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397794 384223268 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632306 C[C@@H](NC(=O)c1cc(OC2(C)COC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C22H21F3N4O3S/c1-12-7-26-19(33-12)15-4-14(5-17(6-15)32-21(3)10-31-11-21)18(30)29-13(2)16-8-27-20(28-9-16)22(23,24)25/h4-9,13H,10-11H2,1-3H3,(H,29,30)/t13-/m1/s1 OYDLDEWAXBGGBJ-CYBMUJFWSA-N 319989 3-[(3- methyloxetan-3- yl)oxy]-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 156::US10202369, Example 156::US10472354, Example 156 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319989 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319989&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397627 384223269 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632308 C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ccc(nc1)C(F)(F)F InChI=1S/C23H22F3N3O3S/c1-13-10-28-22(33-13)17-7-16(8-19(9-17)32-18-5-6-31-12-18)21(30)29-14(2)15-3-4-20(27-11-15)23(24,25)26/h3-4,7-11,14,18H,5-6,12H2,1-2H3,(H,29,30)/t14-,18-/m1/s1 RHAXZNLWUJRHEA-RDTXWAMCSA-N 319990 3-(5-methyl-1,3- thiazol-2-yl)-5- [(3R)- tetrahydrofuran-3- yloxy]-N-{(1R)-1- [6- (trifluoromethyl) pyridin-3- yl]ethyl}benzamide::US10174016, Example 157::US10202369, Example 157::US10472354, Example 157 P2X purinoceptor 3 Homo sapiens 17.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319990 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319990&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397372 384223270 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632310 C[C@@H](NC(=O)c1cc(O[C@@H]2CCCN(C)C2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H26F3N5O2S/c1-14-10-28-22(35-14)17-7-16(8-20(9-17)34-19-5-4-6-32(3)13-19)21(33)31-15(2)18-11-29-23(30-12-18)24(25,26)27/h7-12,15,19H,4-6,13H2,1-3H3,(H,31,33)/t15-,19-/m1/s1 DNVWWBHMIGZIMX-DNVCBOLYSA-N 319991 3-{[(3R)-1- methylpiperidin-3- yl]oxy}-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 158::US10174016, Example 220::US10202369, Example 158::US10472354, Example 158 P2X purinoceptor 3 Homo sapiens 21.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319991 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319991&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397414 384223271 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632312 C[C@@H](NC(=O)c1cc(OCCn2cncn2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C22H20F3N7O2S/c1-13-8-27-20(35-13)16-5-15(6-18(7-16)34-4-3-32-12-26-11-30-32)19(33)31-14(2)17-9-28-21(29-10-17)22(23,24)25/h5-12,14H,3-4H2,1-2H3,(H,31,33)/t14-/m1/s1 HYNLHPVSAUUUKN-CQSZACIVSA-N 319992 3-(5-methyl-1,3- thiazol-2-yl)-5-[2- (1H-1,2,4-triazol- 1-yl)ethoxy]-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 159::US10202369, Example 159::US10472354, Example 159 P2X purinoceptor 3 Homo sapiens 28.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319992 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319992&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397126 384223272 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632314 C[C@@H](NC(=O)c1cc(OCCn2cncn2)cc(c1)-c1ncc(C)s1)c1ccc(nc1)C(F)(F)F InChI=1S/C23H21F3N6O2S/c1-14-10-29-22(35-14)18-7-17(8-19(9-18)34-6-5-32-13-27-12-30-32)21(33)31-15(2)16-3-4-20(28-11-16)23(24,25)26/h3-4,7-13,15H,5-6H2,1-2H3,(H,31,33)/t15-/m1/s1 ZEDPNXXTTLJFPM-OAHLLOKOSA-N 319993 3-(5-methyl-1,3- thiazol-2-yl)-5-[2- (1H-1,2,4-triazol- 1-yl)ethoxy]-N- {(1R)-1-[6- (trifluoromethyl) pyridin-3- yl]ethyl}benzamide::US10174016, Example 160::US10202369, Example 160::US10472354, Example 160 P2X purinoceptor 3 Homo sapiens 28.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319993 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319993&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397838 384223273 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632316 C[C@@H](NC(=O)c1cc(OC2COC2)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F InChI=1S/C21H19F3N4O3S/c1-11-8-25-20(32-11)14-5-13(6-15(7-14)31-16-9-30-10-16)19(29)26-12(2)17-3-4-18(28-27-17)21(22,23)24/h3-8,12,16H,9-10H2,1-2H3,(H,26,29)/t12-/m1/s1 GINDYDBHFAVPIL-GFCCVEGCSA-N 319994 3-(5-methyl-1,3- thiazol-2-yl)-5- (oxetan-3-yloxy)- N-{(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl}benzamide::US10174016, Example 161::US10202369, Example 161::US10472354, Example 161 P2X purinoceptor 3 Homo sapiens 32.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319994 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319994&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397757 384223274 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632318 CC(O)[C@H](C)Oc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C22H23F3N4O3S/c1-11-8-26-20(33-11)16-5-15(6-18(7-16)32-14(4)13(3)30)19(31)29-12(2)17-9-27-21(28-10-17)22(23,24)25/h5-10,12-14,30H,1-4H3,(H,29,31)/t12-,13?,14+/m1/s1 FSGDRFBLPAILDE-YIOYIWSBSA-N 320172 3-[(3-hydroxybutan-2-yl)oxy]-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 339::US10472354, Example 339 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320172 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320172&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 138374915 384223445 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625400 C[C@@H](NC(=O)c1cc(OC[C@@H]2CCCO2)cc(c1)-c1ncc(C)s1)c1cnc(C)cn1 InChI=1S/C23H26N4O3S/c1-14-10-25-21(12-24-14)16(3)27-22(28)17-7-18(23-26-11-15(2)31-23)9-20(8-17)30-13-19-5-4-6-29-19/h7-12,16,19H,4-6,13H2,1-3H3,(H,27,28)/t16-,19+/m1/s1 MANPQCKCYFRFOG-APWZRJJASA-N 319890 N-[(1R)-1-(5-Methylpyrazin-2-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(2S)-tetrahydrofuran-2-ylmethoxy]benzamide::US10174016, Example 57::US10202369, Example 57::US10472354, Example 57 P2X purinoceptor 3 Homo sapiens 25.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319890 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319890&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397390 384223170 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625402 C[C@@H](NC(=O)c1cc(OC[C@@H]2CCCO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H23F3N4O3S/c1-13-9-27-21(34-13)16-6-15(7-19(8-16)33-12-18-4-3-5-32-18)20(31)30-14(2)17-10-28-22(29-11-17)23(24,25)26/h6-11,14,18H,3-5,12H2,1-2H3,(H,30,31)/t14-,18+/m1/s1 MXZPUDRHAAYJOR-KDOFPFPSSA-N 319891 3-(5-Methyl-1,3-thiazol-2-yl)-5-[(2S)-tetrahydrofuran-2-ylmethoxy]-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 58::US10202369, Example 58::US10472354, Example 58 P2X purinoceptor 3 Homo sapiens 4.00 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319891 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319891&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397134 384223171 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625404 C[C@@H](NC(=O)c1cc(OC[C@@H]2CCCO2)cc(c1)-c1ncc(C)s1)c1ccc(C)nn1 InChI=1S/C23H26N4O3S/c1-14-6-7-21(27-26-14)16(3)25-22(28)17-9-18(23-24-12-15(2)31-23)11-20(10-17)30-13-19-5-4-8-29-19/h6-7,9-12,16,19H,4-5,8,13H2,1-3H3,(H,25,28)/t16-,19+/m1/s1 JHPJVAOLQKHAFN-APWZRJJASA-N 319892 N-[(1R)-1-(6-Methylpyridazin-3-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(2S)-tetrahydrofuran-2-ylmethoxy]benzamide::US10174016, Example 59::US10202369, Example 59::US10472354, Example 59 P2X purinoceptor 3 Homo sapiens 13.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319892 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319892&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397721 384223172 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625406 C[C@@H](NC(=O)c1cc(OC[C@@H]2CCCO2)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F InChI=1S/C23H23F3N4O3S/c1-13-11-27-22(34-13)16-8-15(9-18(10-16)33-12-17-4-3-7-32-17)21(31)28-14(2)19-5-6-20(30-29-19)23(24,25)26/h5-6,8-11,14,17H,3-4,7,12H2,1-2H3,(H,28,31)/t14-,17+/m1/s1 KNJYTDFISMIFTK-PBHICJAKSA-N 319893 3-(5-Methyl-1,3-thiazol-2-yl)-5-[(2S)-tetrahydrofuran-2-ylmethoxy]-N-{(1R)-1-[6-(trifluoromethyl)pyridazin-3-yl]ethyl}benzamide::US10174016, Example 60::US10202369, Example 60::US10472354, Example 60 P2X purinoceptor 3 Homo sapiens 11.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319893 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319893&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397124 384223173 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625408 C[C@@H](NC(=O)c1cc(OC[C@H]2CCCO2)cc(c1)-c1ncc(C)s1)c1ccc(C)nn1 InChI=1S/C23H26N4O3S/c1-14-6-7-21(27-26-14)16(3)25-22(28)17-9-18(23-24-12-15(2)31-23)11-20(10-17)30-13-19-5-4-8-29-19/h6-7,9-12,16,19H,4-5,8,13H2,1-3H3,(H,25,28)/t16-,19-/m1/s1 JHPJVAOLQKHAFN-VQIMIIECSA-N 319894 N-[(1R)-1-(6-methylpyridazin-3-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(2R)-tetrahydrofuran-2-ylmethoxy]benzamide::US10174016, Example 61::US10202369, Example 61::US10472354, Example 61 P2X purinoceptor 3 Homo sapiens 14.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319894 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319894&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397475 384223174 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625410 Cc1cnc(s1)-c1cc(OC[C@H]2CCCO2)cc(c1)C(=O)NCc1ccc(C)nn1 InChI=1S/C22H24N4O3S/c1-14-5-6-18(26-25-14)12-23-21(27)16-8-17(22-24-11-15(2)30-22)10-20(9-16)29-13-19-4-3-7-28-19/h5-6,8-11,19H,3-4,7,12-13H2,1-2H3,(H,23,27)/t19-/m1/s1 IFCRFQDQDLUKDL-LJQANCHMSA-N 319895 N-[(6-Methylpyridazin-3-yl)methyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(2R)-tetrahydrofuran-2-ylmethoxy]benzamide::US10174016, Example 62::US10202369, Example 62::US10472354, Example 62 P2X purinoceptor 3 Homo sapiens 85.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319895 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319895&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397725 384223175 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625412 C[C@@H](NC(=O)c1cc(OC[C@H]2CCCO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H23F3N4O3S/c1-13-9-27-21(34-13)16-6-15(7-19(8-16)33-12-18-4-3-5-32-18)20(31)30-14(2)17-10-28-22(29-11-17)23(24,25)26/h6-11,14,18H,3-5,12H2,1-2H3,(H,30,31)/t14-,18-/m1/s1 MXZPUDRHAAYJOR-RDTXWAMCSA-N 319896 3-(5-Methyl-1,3-thiazol-2-yl)-5-[(2R)-tetrahydrofuran-2-ylmethoxy]-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 63::US10202369, Example 63::US10472354, Example 63 P2X purinoceptor 3 Homo sapiens 4.00 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319896 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319896&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397292 384223176 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625414 C[C@@H](NC(=O)c1cc(OC[C@H]2CCCO2)cc(c1)-c1ncc(C)s1)c1cnc(C)cn1 InChI=1S/C23H26N4O3S/c1-14-10-25-21(12-24-14)16(3)27-22(28)17-7-18(23-26-11-15(2)31-23)9-20(8-17)30-13-19-5-4-6-29-19/h7-12,16,19H,4-6,13H2,1-3H3,(H,27,28)/t16-,19-/m1/s1 MANPQCKCYFRFOG-VQIMIIECSA-N 319897 N-[(1R)-1-(5-methylpyrazin-2-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(2R)-tetrahydrofuran-2-ylmethoxy]benzamide::US10174016, Example 64::US10202369, Example 64::US10472354, Example 64 P2X purinoceptor 3 Homo sapiens 53.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319897 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319897&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397244 384223177 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625416 CC(NC(=O)c1cc(OC[C@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ncc(Cl)cc1F InChI=1S/C23H23ClFN3O3S/c1-13-9-27-23(32-13)17-5-16(6-19(7-17)31-12-15-3-4-30-11-15)22(29)28-14(2)21-20(25)8-18(24)10-26-21/h5-10,14-15H,3-4,11-12H2,1-2H3,(H,28,29)/t14?,15-/m0/s1 NHGFOVVSFOISFI-LOACHALJSA-N 319898 N-[1-(5- Chloro-3- fluoropyridin- 2-yl)ethyl]-3- (5-methyL- 1,3-thiazol-2- yl)-5-[(3S)- tetrahydrofuran- 3-ylmethoxy] benzamide::US10174016, Example 65::US10202369, Example 65::US10472354, Example 65 P2X purinoceptor 3 Homo sapiens 3.00 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319898 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319898&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397187 384223178 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625418 Cc1cnc(s1)-c1cc(OC[C@H]2CCOC2)cc(c1)C(=O)NCc1ccc(C)nn1 InChI=1S/C22H24N4O3S/c1-14-3-4-19(26-25-14)11-23-21(27)17-7-18(22-24-10-15(2)30-22)9-20(8-17)29-13-16-5-6-28-12-16/h3-4,7-10,16H,5-6,11-13H2,1-2H3,(H,23,27)/t16-/m0/s1 SKNHRCMFBDROGE-INIZCTEOSA-N 319899 N-[(6- Methylpyridazin- 3-yl)methyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5-[(3S)- tetrahydrofuran- 3-ylmethoxy] benzamide::US10174016, Example 66::US10202369, Example 66::US10472354, Example 66 P2X purinoceptor 3 Homo sapiens 35.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319899 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319899&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397153 384223179 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625420 Cc1cnc(s1)-c1cc(OC[C@H]2CCOC2)cc(c1)C(=O)NCc1cnc(C)cn1 InChI=1S/C22H24N4O3S/c1-14-8-24-19(10-23-14)11-25-21(27)17-5-18(22-26-9-15(2)30-22)7-20(6-17)29-13-16-3-4-28-12-16/h5-10,16H,3-4,11-13H2,1-2H3,(H,25,27)/t16-/m0/s1 MFTNZVDLSIJVDH-INIZCTEOSA-N 319900 N-[(5- Methylpyrazin- 2-yl)methyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5-[(3S)- tetrahydrofuran- 3-ylmethoxy] benzamide::US10174016, Example 67::US10202369, Example 67::US10472354, Example 67 P2X purinoceptor 3 Homo sapiens 186 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319900 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319900&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397127 384223180 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625422 C[C@@H](NC(=O)c1cc(OC[C@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1cnc(C)cn1 InChI=1S/C23H26N4O3S/c1-14-9-25-21(11-24-14)16(3)27-22(28)18-6-19(23-26-10-15(2)31-23)8-20(7-18)30-13-17-4-5-29-12-17/h6-11,16-17H,4-5,12-13H2,1-3H3,(H,27,28)/t16-,17+/m1/s1 VCKXOWQZUNTNDF-SJORKVTESA-N 319901 N-[(1R)-1-(5- Methylpyrazin- 2-yl)ethyl]- 3-(5-methyl- 1,3-thiazol-2- yl)-5-[(3S)- tetrahydrofuran- 3-ylmethoxy] benzamide::US10174016, Example 68::US10202369, Example 68::US10472354, Example 68 P2X purinoceptor 3 Homo sapiens 44.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319901 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319901&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397617 384223181 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625424 CC(NC(=O)c1cc(OC[C@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ncc(F)cc1Cl InChI=1S/C23H23ClFN3O3S/c1-13-9-27-23(32-13)17-5-16(6-19(7-17)31-12-15-3-4-30-11-15)22(29)28-14(2)21-20(24)8-18(25)10-26-21/h5-10,14-15H,3-4,11-12H2,1-2H3,(H,28,29)/t14?,15-/m0/s1 UNHVUPCUCRZLRC-LOACHALJSA-N 319902 N-[1-(3- Chloro-5- fluoropyridin- 2-yl)ethyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5-[(3R)- tetrahydrofuran- 3-ylmethoxy] benzamide::US10174016, Example 69::US10202369, Example 69::US10472354, Example 69 P2X purinoceptor 3 Homo sapiens 15.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319902 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319902&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134338444 384223182 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625426 C[C@@H](NC(=O)c1cc(OC[C@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H23F3N4O3S/c1-13-8-27-21(34-13)17-5-16(6-19(7-17)33-12-15-3-4-32-11-15)20(31)30-14(2)18-9-28-22(29-10-18)23(24,25)26/h5-10,14-15H,3-4,11-12H2,1-2H3,(H,30,31)/t14-,15+/m1/s1 CHPCVIFXIKJNGF-CABCVRRESA-N 319903 3-(5-Methyl- 1,3-thiazol-2- yl)-5-[(3S)- tetrahydrofuran- 3-ylmethoxy]- N-[(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl] benzamide::US10174016, Example 70::US10202369, Example 70::US10472354, Example 70 P2X purinoceptor 3 Homo sapiens 3.00 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319903 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319903&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397748 384223183 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625428 C[C@@H](NC(=O)c1cc(OC[C@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ccc(C)nn1 InChI=1S/C23H26N4O3S/c1-14-4-5-21(27-26-14)16(3)25-22(28)18-8-19(23-24-11-15(2)31-23)10-20(9-18)30-13-17-6-7-29-12-17/h4-5,8-11,16-17H,6-7,12-13H2,1-3H3,(H,25,28)/t16-,17+/m1/s1 DJBMUKYGNBBQBO-SJORKVTESA-N 319904 N-[(1R)-1-(6- Methylpyridazin- 3-yl)ethyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5-[(3S)- tetrahydrofuran- 3-ylmethoxy] benzamide::US10174016, Example 71::US10202369, Example 71::US10472354, Example 71 P2X purinoceptor 3 Homo sapiens 15.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319904 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319904&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397305 384223184 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625430 C[C@@H](NC(=O)c1cc(OC[C@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F InChI=1S/C23H23F3N4O3S/c1-13-10-27-22(34-13)17-7-16(8-18(9-17)33-12-15-5-6-32-11-15)21(31)28-14(2)19-3-4-20(30-29-19)23(24,25)26/h3-4,7-10,14-15H,5-6,11-12H2,1-2H3,(H,28,31)/t14-,15+/m1/s1 BICIIZABCQYPPY-CABCVRRESA-N 319905 3-(5-Methyl- 1,3-thiazol-2- yl)-5-[(3S)- tetrahydrofuran- 3-ylmethoxy]- N-[(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl] benzamide::US10174016, Example 72::US10202369, Example 72::US10472354, Example 72 P2X purinoceptor 3 Homo sapiens 11.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319905 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319905&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397781 384223185 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625432 C[C@@H](NC(=O)c1cc(OC[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H23F3N4O3S/c1-13-8-27-21(34-13)17-5-16(6-19(7-17)33-12-15-3-4-32-11-15)20(31)30-14(2)18-9-28-22(29-10-18)23(24,25)26/h5-10,14-15H,3-4,11-12H2,1-2H3,(H,30,31)/t14-,15-/m1/s1 CHPCVIFXIKJNGF-HUUCEWRRSA-N 319906 3-(5-Methyl- 1,3-thiazol-2- yl)-5-[(3R)- tetrahydrofuran- 3-ylmethoxy]- N-[(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl] benzamide::US10174016, Example 73::US10202369, Example 73::US10472354, Example 73 P2X purinoceptor 3 Homo sapiens 4.00 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319906 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319906&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397238 384223186 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625434 C[C@@H](NC(=O)c1cc(OC[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1cnc(C)cn1 InChI=1S/C23H26N4O3S/c1-14-9-25-21(11-24-14)16(3)27-22(28)18-6-19(23-26-10-15(2)31-23)8-20(7-18)30-13-17-4-5-29-12-17/h6-11,16-17H,4-5,12-13H2,1-3H3,(H,27,28)/t16-,17-/m1/s1 VCKXOWQZUNTNDF-IAGOWNOFSA-N 319907 N-[(1R)-1-(5- Methylpyrazin- 2-yl)ethyl]- 3-(5-methyl- 1,3-thiazol-2- yl)-5-[(3R)- tetrahydrofuran- 3-ylmethoxy] benzamide::US10174016, Example 74::US10202369, Example 74::US10472354, Example 74 P2X purinoceptor 3 Homo sapiens 14.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319907 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319907&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397532 384223187 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625436 Cc1cnc(s1)-c1cc(OC[C@@H]2CCOC2)cc(c1)C(=O)NCc1ccc(C)nn1 InChI=1S/C22H24N4O3S/c1-14-3-4-19(26-25-14)11-23-21(27)17-7-18(22-24-10-15(2)30-22)9-20(8-17)29-13-16-5-6-28-12-16/h3-4,7-10,16H,5-6,11-13H2,1-2H3,(H,23,27)/t16-/m1/s1 SKNHRCMFBDROGE-MRXNPFEDSA-N 319908 N-[(6- Methylpyridazin- 3-yl)methyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5-[(3R)- tetrahydrofuran- 3-ylmethoxy] benzamide::US10174016, Example 75::US10202369, Example 75::US10472354, Example 75 P2X purinoceptor 3 Homo sapiens 38.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319908 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319908&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397221 384223188 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625438 Cc1cnc(s1)-c1cc(OC[C@@H]2CCOC2)cc(c1)C(=O)NCc1cnc(C)cn1 InChI=1S/C22H24N4O3S/c1-14-8-24-19(10-23-14)11-25-21(27)17-5-18(22-26-9-15(2)30-22)7-20(6-17)29-13-16-3-4-28-12-16/h5-10,16H,3-4,11-13H2,1-2H3,(H,25,27)/t16-/m1/s1 MFTNZVDLSIJVDH-MRXNPFEDSA-N 319909 N-[(5- Methylpyrazin- 2-yl)methyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5-[(3R)- tetrahydrofuran- 3-ylmethoxy] benzamide::US10174016, Example 76::US10202369, Example 76::US10472354, Example 76 P2X purinoceptor 3 Homo sapiens 201 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319909 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319909&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397850 384223189 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625440 C[C@@H](NC(=O)c1cc(OC[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ccc(C)nn1 InChI=1S/C23H26N4O3S/c1-14-4-5-21(27-26-14)16(3)25-22(28)18-8-19(23-24-11-15(2)31-23)10-20(9-18)30-13-17-6-7-29-12-17/h4-5,8-11,16-17H,6-7,12-13H2,1-3H3,(H,25,28)/t16-,17-/m1/s1 DJBMUKYGNBBQBO-IAGOWNOFSA-N 319910 N-[(1R)-1-(6- Methylpyridazin- 3-yl)ethyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5-[(3R)- tetrahydrofuran- 3-ylmethoxy] benzomide::US10174016, Example 77::US10202369, Example 77::US10472354, Example 77 P2X purinoceptor 3 Homo sapiens 10.00 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319910 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319910&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397806 384223190 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625442 CC(NC(=O)c1cc(OC[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ncc(Cl)cc1F InChI=1S/C23H23ClFN3O3S/c1-13-9-27-23(32-13)17-5-16(6-19(7-17)31-12-15-3-4-30-11-15)22(29)28-14(2)21-20(25)8-18(24)10-26-21/h5-10,14-15H,3-4,11-12H2,1-2H3,(H,28,29)/t14?,15-/m1/s1 NHGFOVVSFOISFI-YSSOQSIOSA-N 319911 N-[1-(5- Chloro-3- fluoropyridin- 2-yl)ethyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5-[(3R)- tetrahydrofuran- 3-ylmethoxy] benzamide::US10174016, Example 78::US10202369, Example 78::US10472354, Example 78 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319911 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319911&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397720 384223191 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625444 C[C@@H](NC(=O)c1cc(OC[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F InChI=1S/C23H23F3N4O3S/c1-13-10-27-22(34-13)17-7-16(8-18(9-17)33-12-15-5-6-32-11-15)21(31)28-14(2)19-3-4-20(30-29-19)23(24,25)26/h3-4,7-10,14-15H,5-6,11-12H2,1-2H3,(H,28,31)/t14-,15-/m1/s1 BICIIZABCQYPPY-HUUCEWRRSA-N 319912 3-(5-Methyl- 1,3-thiazol-2- yl)-5-[(3R)- tetrahydrofuran- 3-ylmethoxy]- N-[(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl] benzamide::US10174016, Example 79::US10202369, Example 79::US10472354, Example 79 P2X purinoceptor 3 Homo sapiens 9.00 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319912 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319912&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397596 384223192 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625446 CC(NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(C)s1)c1ncc(F)cc1Cl InChI=1S/C23H23ClFN3O3S/c1-13-11-27-23(32-13)16-7-15(8-19(9-16)31-18-3-5-30-6-4-18)22(29)28-14(2)21-20(24)10-17(25)12-26-21/h7-12,14,18H,3-6H2,1-2H3,(H,28,29) SBZIYANVWYKJKX-UHFFFAOYSA-N 319913 N-[1-(3- Chloro-5- fluoropyridin- 2-yl)ethyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5- (tetrahydro- 2H-pyran-4- yloxy) benzamide::US10174016, Example 80::US10202369, Example 80::US10472354, Example 80 P2X purinoceptor 3 Homo sapiens 12.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319913 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319913&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397324 384223193 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625448 CC(NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(C)s1)c1ncc(Cl)cc1F InChI=1S/C23H23ClFN3O3S/c1-13-11-27-23(32-13)16-7-15(8-19(9-16)31-18-3-5-30-6-4-18)22(29)28-14(2)21-20(25)10-17(24)12-26-21/h7-12,14,18H,3-6H2,1-2H3,(H,28,29) UXQVDYSQMZTJPS-UHFFFAOYSA-N 319914 N-[1-(5- Chloro-3- fluoropyridin- 2-yl)ethyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5- (tetrahydro- 2H-pyran-4- yloxy) benzamide::US10174016, Example 81::US10202369, Example 81::US10472354, Example 81 P2X purinoceptor 3 Homo sapiens 3.00 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319914 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319914&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397622 384223194 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625450 Cc1cnc(s1)-c1cc(OC2CCOCC2)cc(c1)C(=O)NCc1ccc(C)nn1 InChI=1S/C22H24N4O3S/c1-14-3-4-18(26-25-14)13-23-21(27)16-9-17(22-24-12-15(2)30-22)11-20(10-16)29-19-5-7-28-8-6-19/h3-4,9-12,19H,5-8,13H2,1-2H3,(H,23,27) LSYGQIAUTJTZDJ-UHFFFAOYSA-N 319915 N-[(6- Methylpyridazin- 3-yl)methyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5- (tetrahydro- 2H-pyran-4- yloxy) benzamide::US10174016, Example 82::US10202369, Example 82::US10472354, Example 82 P2X purinoceptor 3 Homo sapiens 28.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319915 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319915&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397341 384223195 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625452 Cc1cnc(s1)-c1cc(OC2CCOCC2)cc(c1)C(=O)NCc1cnc(C)cn1 InChI=1S/C22H24N4O3S/c1-14-10-24-18(12-23-14)13-25-21(27)16-7-17(22-26-11-15(2)30-22)9-20(8-16)29-19-3-5-28-6-4-19/h7-12,19H,3-6,13H2,1-2H3,(H,25,27) YXUSESJBYZNMQE-UHFFFAOYSA-N 319916 N-[(5- Methylpyrazin- 2-yl)methyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5- (tetrahydro- 2H-pyran-4- yloxy) benzamide::US10174016, Example 83::US10202369, Example 83::US10472354, Example 83 P2X purinoceptor 3 Homo sapiens 125 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319916 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319916&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397170 384223196 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625454 C[C@@H](NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(C)s1)c1cnc(C)cn1 InChI=1S/C23H26N4O3S/c1-14-11-25-21(13-24-14)16(3)27-22(28)17-8-18(23-26-12-15(2)31-23)10-20(9-17)30-19-4-6-29-7-5-19/h8-13,16,19H,4-7H2,1-3H3,(H,27,28)/t16-/m1/s1 USCQOVGUOPYDKF-MRXNPFEDSA-N 319917 N-[(1R)-1-(5- Methylpyrazin- 2-yl)ethyl]- 3-(5-methyl- 1,3-thiazol-2- yl)-5- (tetrahydro- 2H-pyran-4- yloxy) benzamide::US10174016, Example 84::US10202369, Example 84::US10472354, Example 84 P2X purinoceptor 3 Homo sapiens 26.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319917 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319917&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397618 384223197 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625456 C[C@@H](NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H23F3N4O3S/c1-13-10-27-21(34-13)16-7-15(8-19(9-16)33-18-3-5-32-6-4-18)20(31)30-14(2)17-11-28-22(29-12-17)23(24,25)26/h7-12,14,18H,3-6H2,1-2H3,(H,30,31)/t14-/m1/s1 WGQQHPGXKFPPTQ-CQSZACIVSA-N 319918 3-(5-Methyl- 1,3-thiazol-2- yl)-5- (tetrahydro- 2H-pyran-4- yloxy)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 85::US10202369, Example 85::US10472354, Example 85 P2X purinoceptor 3 Homo sapiens 10.00 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319918 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319918&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397801 384223198 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625458 COc1ccc(cn1)[C@@H](C)NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(C)s1 InChI=1S/C24H27N3O4S/c1-15-13-26-24(32-15)19-10-18(11-21(12-19)31-20-6-8-30-9-7-20)23(28)27-16(2)17-4-5-22(29-3)25-14-17/h4-5,10-14,16,20H,6-9H2,1-3H3,(H,27,28)/t16-/m1/s1 HOSIWEZQKWEZJW-MRXNPFEDSA-N 319919 N-[(1R)-1-(6- Methoxypyridin- 3-yl)ethyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5- (tetrahydro- 2H-pyran-4- yloxy) benzamide::US10174016, Example 86::US10202369, Example 86::US10472354, Example 86 P2X purinoceptor 3 Homo sapiens 12.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319919 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319919&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397310 384223199 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625460 C[C@@H](NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(C)s1)c1ccc(C)nn1 InChI=1S/C23H26N4O3S/c1-14-4-5-21(27-26-14)16(3)25-22(28)17-10-18(23-24-13-15(2)31-23)12-20(11-17)30-19-6-8-29-9-7-19/h4-5,10-13,16,19H,6-9H2,1-3H3,(H,25,28)/t16-/m1/s1 OIHQARAAGWIFBW-MRXNPFEDSA-N 319920 N-[(1R)-1-(6- Methylpyridazin- 3-yl)ethyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5- (tetrahydro- 2H-pyran-4- yloxy) benzamide::US10174016, Example 87::US10202369, Example 87::US10472354, Example 87 P2X purinoceptor 3 Homo sapiens 15.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319920 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319920&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397290 384223200 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625462 COc1ccc(CNC(=O)c2cc(OC3CCOCC3)cc(c2)-c2ncc(C)s2)nn1 InChI=1S/C22H24N4O4S/c1-14-12-24-22(31-14)16-9-15(10-19(11-16)30-18-5-7-29-8-6-18)21(27)23-13-17-3-4-20(28-2)26-25-17/h3-4,9-12,18H,5-8,13H2,1-2H3,(H,23,27) FUPOQWQPMIFATK-UHFFFAOYSA-N 319921 N-[(6- Methoxy- pyridazin-3- yl)methyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5- (tetrahydro- 2H-pyran-4- yloxy) benzamide::US10174016, Example 88::US10202369, Example 88::US10472354, Example 88 P2X purinoceptor 3 Homo sapiens 30.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319921 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319921&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397556 384223201 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632196 Cc1cnc(s1)-c1cc(Oc2ccnc(C)c2)cc(c1)C(=O)NCc1ccc(C)nn1 InChI=1S/C23H21N5O2S/c1-14-4-5-19(28-27-14)13-25-22(29)17-9-18(23-26-12-16(3)31-23)11-21(10-17)30-20-6-7-24-15(2)8-20/h4-12H,13H2,1-3H3,(H,25,29) XCSQCNBYINKWNK-UHFFFAOYSA-N 319934 N-[(6- Methyl- pyridazin-3- yl)methyl]-3- [(2- methylpyridin- 4-yl)oxy]-5- (5-methyl- 1,3-thiazol-2- yl)benzamide::US10174016, Example 101::US10202369, Example 101::US10472354, Example 101 P2X purinoceptor 3 Homo sapiens 15.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319934 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319934&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397744 384223214 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632198 C[C@@H](NC(=O)c1cc(Oc2ccnc(C)c2)cc(c1)-c1ncc(C)s1)c1cnc(C)cn1 InChI=1S/C24H23N5O2S/c1-14-7-20(5-6-25-14)31-21-9-18(8-19(10-21)24-28-12-16(3)32-24)23(30)29-17(4)22-13-26-15(2)11-27-22/h5-13,17H,1-4H3,(H,29,30)/t17-/m1/s1 QEKNBUCJINMCOL-QGZVFWFLSA-N 319935 N-[(1R)-1-(5- Methylpyrazin- 2-yl)ethyl]- 3-[(2- methylpyridin- 4-yl)oxy]-5- (5-methyl- 1,3-thiazol-2- yl)benzamide::US10174016, Example 102::US10202369, Example 102::US10472354, Example 102 P2X purinoceptor 3 Homo sapiens 10.00 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319935 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319935&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397697 384223215 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632200 C[C@@H](NC(=O)c1cc(Oc2ccnc(C)c2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H20F3N5O2S/c1-13-6-19(4-5-28-13)34-20-8-16(7-17(9-20)22-29-10-14(2)35-22)21(33)32-15(3)18-11-30-23(31-12-18)24(25,26)27/h4-12,15H,1-3H3,(H,32,33)/t15-/m1/s1 JXFGKHKXOUTTKZ-OAHLLOKOSA-N 319936 3-[(2- Methylpyridin- 4-yl)oxy]-5- (5-methyl- 1,3-thiazol-2- yl)-N-{(1R)-1- [2- (trifluorometh- yl)pyrimidin- 5- yl]ethyl} benzamide::US10174016, Example 103::US10202369, Example 103::US10472354, Example 103 P2X purinoceptor 3 Homo sapiens 2.00 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319936 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319936&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397214 384223216 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632202 Cc1cnc(s1)-c1cc(Oc2ccnc(C)c2)cc(c1)C(=O)NCc1cnc(C)cn1 InChI=1S/C23H21N5O2S/c1-14-6-20(4-5-24-14)30-21-8-17(7-18(9-21)23-28-11-16(3)31-23)22(29)27-13-19-12-25-15(2)10-26-19/h4-12H,13H2,1-3H3,(H,27,29) FHRXECCRJLFVTP-UHFFFAOYSA-N 319937 N-[(5- Methylpyrazin- 2- yl)methyl]-3- [(2- methylpyridin- 4-yl)oxy]-5- (5-methyl- 1,3-thiazol-2- yl)benzamide::US10174016, Example 104::US10202369, Example 104::US10472354, Example 104 P2X purinoceptor 3 Homo sapiens 51.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319937 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319937&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397645 384223217 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632204 C[C@@H](NC(=O)c1cc(Oc2ccnc(C)c2)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F InChI=1S/C24H20F3N5O2S/c1-13-8-18(6-7-28-13)34-19-10-16(9-17(11-19)23-29-12-14(2)35-23)22(33)30-15(3)20-4-5-21(32-31-20)24(25,26)27/h4-12,15H,1-3H3,(H,30,33)/t15-/m1/s1 DZQXNDYGTRQHHO-OAHLLOKOSA-N 319938 3-[(2- Methylpyridin- 4-yl)oxy]-5- (5-methyl- 1,3-thiazol-2- yl)-N-{(1R)-1- [6- (trifluorometh- yl)pyridazin- 3- yl]ethyl} benzamide::US10174016, Example 105::US10202369, Example 105::US10472354, Example 105 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319938 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319938&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397847 384223218 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632206 C[C@@H](NC(=O)c1cc(Oc2ccnc(C)c2)cc(c1)-c1ncc(C)s1)c1cnc(C)nc1 InChI=1S/C24H23N5O2S/c1-14-7-21(5-6-25-14)31-22-9-18(8-19(10-22)24-28-11-15(2)32-24)23(30)29-16(3)20-12-26-17(4)27-13-20/h5-13,16H,1-4H3,(H,29,30)/t16-/m1/s1 AVOXIOANORGYFZ-MRXNPFEDSA-N 319939 3-[(2-methylpyridin-4-yl)oxy]-N-[(1R)-1-(2-methylpyrimidin-5-yl)ethyl]-5-(5-methyl-1,3-thiazol-2-yl)benzamide::US10174016, Example 106::US10202369, Example 106::US10472354, Example 106 P2X purinoceptor 3 Homo sapiens 16.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319939 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319939&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397227 384223219 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632208 C[C@@H](NC(=O)c1cc(Oc2ccnc(C)c2)cc(c1)-c1ncc(C)s1)c1ccc(C)nc1 InChI=1S/C25H24N4O2S/c1-15-5-6-19(14-27-15)18(4)29-24(30)20-10-21(25-28-13-17(3)32-25)12-23(11-20)31-22-7-8-26-16(2)9-22/h5-14,18H,1-4H3,(H,29,30)/t18-/m1/s1 PNIOXTPFLIQKJT-GOSISDBHSA-N 319940 N-[(1R)-1-(6- Methylpyridin- 3-yl)ethyl]- 3-[(2- methylpyridin- 4-yl)oxy]-5- (5-methyl- 1,3-thiazol-2- yl)benzamide::US10174016, Example 107::US10202369, Example 107::US10472354, Example 107 P2X purinoceptor 3 Homo sapiens 9.00 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319940 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319940&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397329 384223220 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632210 C[C@@H](NC(=O)c1cc(Oc2ccc(C)nc2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H20F3N5O2S/c1-13-4-5-19(12-28-13)34-20-7-16(6-17(8-20)22-29-9-14(2)35-22)21(33)32-15(3)18-10-30-23(31-11-18)24(25,26)27/h4-12,15H,1-3H3,(H,32,33)/t15-/m1/s1 ASXORIIIQIGPLA-OAHLLOKOSA-N 319941 3-[(6-Methylpyridin-3-yl)oxy]-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 108::US10202369, Example 108::US10472354, Example 108 P2X purinoceptor 3 Homo sapiens 11.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319941 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319941&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397249 384223221 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632212 C[C@@H](NC(=O)c1cc(Oc2nnc(C)s2)cc(c1)-c1ncc(C)s1)c1cnc(C)cn1 InChI=1S/C21H20N6O2S2/c1-11-8-23-18(10-22-11)13(3)25-19(28)15-5-16(20-24-9-12(2)30-20)7-17(6-15)29-21-27-26-14(4)31-21/h5-10,13H,1-4H3,(H,25,28)/t13-/m1/s1 SHPJQOXSFBKQMY-CYBMUJFWSA-N 319942 N-[(1R)-1-(5- Methylpyrazin- 2-yl)ethyl]-3- [(5-methyl- 1,3,4- thiadiazol-2- yl)oxy]-5-(5- methyl-1,3- thiazol-2- yl)benzamide::US10174016, Example 109::US10202369, Example 109::US10472354, Example 109 P2X purinoceptor 3 Homo sapiens 235 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319942 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319942&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397425 384223222 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632214 C[C@@H](NC(=O)c1cc(Oc2nnc(C)s2)cc(c1)-c1ncc(C)s1)c1ccc(C)nn1 InChI=1S/C21H20N6O2S2/c1-11-5-6-18(26-24-11)13(3)23-19(28)15-7-16(20-22-10-12(2)30-20)9-17(8-15)29-21-27-25-14(4)31-21/h5-10,13H,1-4H3,(H,23,28)/t13-/m1/s1 YBUIRLYLJALMRA-CYBMUJFWSA-N 319943 N-[(1R)-1-(6- Methylpyridazin- 3-yl)ethyl]- 3-[(5-methyl- 1,3,4- thiadiazol-2- yl)oxy]-5-(5- methyl-1,3- thiazol-2- yl)benzamide::US10174016, Example 110::US10202369, Example 110::US10472354, Example 110 P2X purinoceptor 3 Homo sapiens 114 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319943 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319943&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397265 384223223 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632216 C[C@@H](NC(=O)c1cc(Oc2nnc(C)s2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C21H17F3N6O2S2/c1-10-7-25-18(33-10)14-4-13(5-16(6-14)32-20-30-29-12(3)34-20)17(31)28-11(2)15-8-26-19(27-9-15)21(22,23)24/h4-9,11H,1-3H3,(H,28,31)/t11-/m1/s1 FIVDAXBJTLXBHI-LLVKDONJSA-N 319944 3-[(5-Methyl- 1,3,4- thiadiazol-2- yl)oxy]-5-(5- methyl-1,3- thiazol-2-yl)- N-[(1R)-1-[2- (trifluorometh- yl)pyrimidin-5- yl]ethyl] benzamide::US10174016, Example 111::US10202369, Example 111::US10472354, Example 111 P2X purinoceptor 3 Homo sapiens 16.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319944 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319944&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397223 384223224 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632218 C[C@@H](NC(=O)c1cc(Oc2nccs2)cc(c1)-c1ncc(C)s1)c1cnc(C)cn1 InChI=1S/C21H19N5O2S2/c1-12-9-24-18(11-23-12)14(3)26-19(27)15-6-16(20-25-10-13(2)30-20)8-17(7-15)28-21-22-4-5-29-21/h4-11,14H,1-3H3,(H,26,27)/t14-/m1/s1 QJIZPYNDSFDLFQ-CQSZACIVSA-N 319945 N-[(1R)-1-(5- Methylpyrazin- 2-yl)ethyl]-3- (5-methyl-1,3- thiazol-2-yl)-5- (1,3-thiazol-2- yloxy)benzamide::US10174016, Example 112::US10472354, Example 112 P2X purinoceptor 3 Homo sapiens 61.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319945 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319945&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397232 384223225 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632220 C[C@@H](NC(=O)c1cc(Oc2nccs2)cc(c1)-c1ncc(C)s1)c1ccc(C)nn1 InChI=1S/C21H19N5O2S2/c1-12-4-5-18(26-25-12)14(3)24-19(27)15-8-16(20-23-11-13(2)30-20)10-17(9-15)28-21-22-6-7-29-21/h4-11,14H,1-3H3,(H,24,27)/t14-/m1/s1 KTZHJRKMBNLACT-CQSZACIVSA-N 319946 N-[(1R)-1-(6- Methylpyridazin- 3-yl)ethyl]- 3-(5-methyl- 1,3-thiazol-2- yl)-5-(1,3- thiazol-2- yloxy)benzamide::US10174016, Example 113::US10202369, Example 113::US10472354, Example 113 P2X purinoceptor 3 Homo sapiens 43.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319946 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319946&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397679 384223226 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632222 C[C@@H](NC(=O)c1cc(Oc2nccs2)cc(c1)-c1ncc(C)s1)c1ccc(C)nc1 InChI=1S/C22H20N4O2S2/c1-13-4-5-16(12-24-13)15(3)26-20(27)17-8-18(21-25-11-14(2)30-21)10-19(9-17)28-22-23-6-7-29-22/h4-12,15H,1-3H3,(H,26,27)/t15-/m1/s1 WJNIKDPPMLYZOS-OAHLLOKOSA-N 319947 N-[(1R)-1-(6- Methylpyridin- 3-yl)ethyl]-3- (5-methyl-1,3- thiazol-2-yl)-5- (1,3-thiazol-2- yloxy)benzamide::US10174016, Example 114::US10202369, Example 114::US10472354, Example 114 P2X purinoceptor 3 Homo sapiens 38.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319947 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319947&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397612 384223227 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632224 COC(C)(C)COc1cc(cc(c1)-c1ncc(Cl)s1)C(=O)N[C@H](C)c1ccc(Cl)cn1 InChI=1S/C22H23Cl2N3O3S/c1-13(18-6-5-16(23)10-25-18)27-20(28)14-7-15(21-26-11-19(24)31-21)9-17(8-14)30-12-22(2,3)29-4/h5-11,13H,12H2,1-4H3,(H,27,28)/t13-/m1/s1 MHZRDUGBKYAKKB-CYBMUJFWSA-N 319948 N-[(1R)-1-(5-Chloropyridin-2-yl)ethyl]-3-(5-chloro-1,3-thiazol-2-yl)-5-(2-methoxy-2-methylpropoxy)benzamide::US10174016, Example 115::US10202369, Example 115::US10472354, Example 115 P2X purinoceptor 3 Homo sapiens 15.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319948 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319948&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397201 384223228 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632226 COC(C)(C)COc1cc(cc(c1)-c1ncc(Cl)s1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C22H22ClF3N4O3S/c1-12(15-8-28-20(29-9-15)22(24,25)26)30-18(31)13-5-14(19-27-10-17(23)34-19)7-16(6-13)33-11-21(2,3)32-4/h5-10,12H,11H2,1-4H3,(H,30,31)/t12-/m1/s1 QSHVLLWXZBADRN-GFCCVEGCSA-N 319949 3-(5-Chloro-1,3-thiazol-2-yl)-5-(2-methoxy-2-methylpropoxy)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 116::US10202369, Example 116::US10472354, Example 116 P2X purinoceptor 3 Homo sapiens 210 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319949 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319949&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397235 384223229 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632228 COC(C)(C)COc1cc(cc(c1)-c1ncc(Cl)s1)C(=O)N[C@H](C)c1cnc(C)cn1 InChI=1S/C22H25ClN4O3S/c1-13-9-25-18(10-24-13)14(2)27-20(28)15-6-16(21-26-11-19(23)31-21)8-17(7-15)30-12-22(3,4)29-5/h6-11,14H,12H2,1-5H3,(H,27,28)/t14-/m1/s1 IVUVTQZOIPAQFU-CQSZACIVSA-N 319950 3-(5-Chloro-1,3-thiazol-2-yl)-5-(2-methoxy-2-methylpropoxy)-N-[(1R)-1-(5-methylpyrazin-2-yl)ethyl]benzamide::US10174016, Example 117::US10202369, Example 117::US10472354, Example 117 P2X purinoceptor 3 Homo sapiens 36.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319950 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319950&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397711 384223230 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632230 Cc1ccc(CNC(=O)c2cc(OCC3CCOCC3)cc(c2)-c2ncc(s2)C(F)(F)F)nn1 InChI=1S/C23H23F3N4O3S/c1-14-2-3-18(30-29-14)11-27-21(31)16-8-17(22-28-12-20(34-22)23(24,25)26)10-19(9-16)33-13-15-4-6-32-7-5-15/h2-3,8-10,12,15H,4-7,11,13H2,1H3,(H,27,31) JVFRARFSFIRWBD-UHFFFAOYSA-N 319951 N-[(6-Methylpyridazin-3-yl)methyl]-3-(tetrahydro-2H-pyran-4-ylmethoxy)-5-[5-(trifluoromethyl)-1,3-thiazol-2-yl]benzamide::US10174016, Example 118::US10202369, Example 118::US10472354, Example 118 P2X purinoceptor 3 Homo sapiens 198 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319951 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319951&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397366 384223231 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632232 Cc1ccc(CNC(=O)c2cc(OCC3CCOCC3)cc(c2)-c2ncc(s2)C2CCC2)nn1 InChI=1S/C26H30N4O3S/c1-17-5-6-22(30-29-17)14-27-25(31)20-11-21(26-28-15-24(34-26)19-3-2-4-19)13-23(12-20)33-16-18-7-9-32-10-8-18/h5-6,11-13,15,18-19H,2-4,7-10,14,16H2,1H3,(H,27,31) UIEYRDUAWDAEID-UHFFFAOYSA-N 319952 3-(5-Cyclobutyl-1,3-thiazol-2-yl)-N-[(6-methylpyridazin-3-yl)methyl]-5-(tetrahydro-2H-pyran-4-ylmethoxy)benzamide::US10174016, Example 119::US10202369, Example 119::US10472354, Example 119 P2X purinoceptor 3 Homo sapiens 24.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319952 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319952&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397447 384223232 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632234 C[C@@H](NC(=O)c1cc(OCC2CCOCC2)cc(c1)-c1ncc(s1)C1CCC1)c1cnc(nc1)C(F)(F)F InChI=1S/C27H29F3N4O3S/c1-16(21-12-32-26(33-13-21)27(28,29)30)34-24(35)19-9-20(25-31-14-23(38-25)18-3-2-4-18)11-22(10-19)37-15-17-5-7-36-8-6-17/h9-14,16-18H,2-8,15H2,1H3,(H,34,35)/t16-/m1/s1 XFOWUTGLWQUPCN-MRXNPFEDSA-N 319953 3-(5-Cyclobutyl-1,3-thiazol-2-yl)-5-(tetrahydro-2H-pyran-4-ylmethoxy)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 120::US10202369, Example 120::US10472354, Example 120 P2X purinoceptor 3 Homo sapiens 14.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319953 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319953&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397437 384223233 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632236 C[C@@H](NC(=O)c1cc(OC[C@H]2CCOC2)cc(c1)-c1ncc(s1)C1CCC1)c1cnc(C)cn1 InChI=1S/C26H30N4O3S/c1-16-11-28-23(12-27-16)17(2)30-25(31)20-8-21(26-29-13-24(34-26)19-4-3-5-19)10-22(9-20)33-15-18-6-7-32-14-18/h8-13,17-19H,3-7,14-15H2,1-2H3,(H,30,31)/t17-,18+/m1/s1 ZBRXLMDGZXDHGV-MSOLQXFVSA-N 319954 3-(5-Cyclobutyl-1,3-thiazol-2-yl)-N-[(1R)-1-(5-methylpyrazin-2-yl)ethyl]-5-[(3S)-tetrahydrofuran-3-ylmethoxy]benzamide::US10174016, Example 121::US10202369, Example 121::US10472354, Example 271 P2X purinoceptor 3 Homo sapiens 79.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319954 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319954&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397486 384223234 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632238 Cc1ccc(CNC(=O)c2cc(OC[C@H]3CCOC3)cc(c2)-c2ncc(s2)C2CCC2)nn1 InChI=1S/C25H28N4O3S/c1-16-5-6-21(29-28-16)12-26-24(30)19-9-20(25-27-13-23(33-25)18-3-2-4-18)11-22(10-19)32-15-17-7-8-31-14-17/h5-6,9-11,13,17-18H,2-4,7-8,12,14-15H2,1H3,(H,26,30)/t17-/m0/s1 DCRIJNFHBDAZLX-KRWDZBQOSA-N 319955 3-(5-Cyclobutyl-1,3-thiazol-2-yl)-N-[(6-methylpyridazin-3-yl)methyl]-5-[(3S)-tetrahydrofuran-3-ylmethoxy]benzamide::US10174016, Example 122::US10202369, Example 122::US10472354, Example 122 P2X purinoceptor 3 Homo sapiens 106 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319955 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319955&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397270 384223235 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632240 C[C@@H](NC(=O)c1cc(OC[C@H]2CCOC2)cc(c1)-c1ncc(s1)C1CCC1)c1cnc(nc1)C(F)(F)F InChI=1S/C26H27F3N4O3S/c1-15(20-10-31-25(32-11-20)26(27,28)29)33-23(34)18-7-19(24-30-12-22(37-24)17-3-2-4-17)9-21(8-18)36-14-16-5-6-35-13-16/h7-12,15-17H,2-6,13-14H2,1H3,(H,33,34)/t15-,16+/m1/s1 JWRPHAGJMIAQMD-CVEARBPZSA-N 319956 3-(5-Cyclobutyl-1,3-thiazol-2-yl)-5-[(3S)-tetrahydrofuran-3-ylmethoxy]-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 123::US10202369, Example 123::US10472354, Example 272 P2X purinoceptor 3 Homo sapiens 46.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319956 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319956&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397161 384223236 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632242 C[C@@H](NC(=O)c1cc(OCC2CCOCC2)cc(c1)-c1ncc(s1)C1CCC1)c1cnc(C)nc1 InChI=1S/C27H32N4O3S/c1-17(23-13-28-18(2)29-14-23)31-26(32)21-10-22(27-30-15-25(35-27)20-4-3-5-20)12-24(11-21)34-16-19-6-8-33-9-7-19/h10-15,17,19-20H,3-9,16H2,1-2H3,(H,31,32)/t17-/m1/s1 WEHPOEFAIDTUPC-QGZVFWFLSA-N 319957 3-(5-Cyclobutyl-1,3-thiazol-2-yl)-N-[(1R)-1-(2-methylpyrimidin-5-yl)ethyl]-5-(tetrahydro-2H-pyran-4-ylmethoxy)benzamide::US10174016, Example 124::US10202369, Example 124::US10472354, Example 124 P2X purinoceptor 3 Homo sapiens 27.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319957 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319957&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397614 384223237 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632244 CCc1cnc(s1)-c1cc(OCC2CCOCC2)cc(c1)C(=O)N[C@H](C)c1cnc(C)nc1 InChI=1S/C25H30N4O3S/c1-4-23-14-28-25(33-23)20-9-19(10-22(11-20)32-15-18-5-7-31-8-6-18)24(30)29-16(2)21-12-26-17(3)27-13-21/h9-14,16,18H,4-8,15H2,1-3H3,(H,29,30)/t16-/m1/s1 DTZIYRRTWOGOEN-MRXNPFEDSA-N 319958 3-(5-Ethyl-1,3-thiazol-2-yl)-N-[(1R)-1-(2-methylpyrimidin-5-yl)ethyl]-5-(tetrahydro-2H-pyran-4-ylmethoxy)benzamide::US10174016, Example 125::US10202369, Example 125::US10472354, Example 125 P2X purinoceptor 3 Homo sapiens 3.00 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319958 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319958&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397256 384223238 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632246 CC(C)c1cnc(s1)-c1cc(OCC2CCOCC2)cc(c1)C(=O)N[C@H](C)c1cnc(C)nc1 InChI=1S/C26H32N4O3S/c1-16(2)24-14-29-26(34-24)21-9-20(10-23(11-21)33-15-19-5-7-32-8-6-19)25(31)30-17(3)22-12-27-18(4)28-13-22/h9-14,16-17,19H,5-8,15H2,1-4H3,(H,30,31)/t17-/m1/s1 OFIYJECBOJUELW-QGZVFWFLSA-N 319959 N-[(1R)-1-(2-Methylpyrimidin-5-yl)ethyl]-3-[5-(propan-2-yl)-1,3-thiazol-2-yl]-5-(tetrahydro-2H-pyran-4-ylmethoxy)benzamide::US10174016, Example 126::US10202369, Example 126::US10472354, Example 126 P2X purinoceptor 3 Homo sapiens 34.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319959 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319959&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397136 384223239 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632248 C[C@@H](NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(s1)C1CCC1)c1ccc(C)nn1 InChI=1S/C26H30N4O3S/c1-16-6-7-23(30-29-16)17(2)28-25(31)19-12-20(26-27-15-24(34-26)18-4-3-5-18)14-22(13-19)33-21-8-10-32-11-9-21/h6-7,12-15,17-18,21H,3-5,8-11H2,1-2H3,(H,28,31)/t17-/m1/s1 WWWCBSCSEOPHLV-QGZVFWFLSA-N 319960 3-(5-Cyclobutyl-1,3-thiazol-2-yl)-N-[(1R)-1-(6-methylpyridazin-3-yl)ethyl]-5-(tetrahydro-2H-pyran-4-yloxy)benzamide::US10174016, Example 127::US10202369, Example 127::US10472354, Example 127 P2X purinoceptor 3 Homo sapiens 111 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319960 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319960&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397331 384223240 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632250 CCc1cnc(s1)-c1cc(OC2CCOCC2)cc(c1)C(=O)N[C@H](C)c1ccc(C)nn1 InChI=1S/C24H28N4O3S/c1-4-21-14-25-24(32-21)18-11-17(12-20(13-18)31-19-7-9-30-10-8-19)23(29)26-16(3)22-6-5-15(2)27-28-22/h5-6,11-14,16,19H,4,7-10H2,1-3H3,(H,26,29)/t16-/m1/s1 ZSPSPZOSCRXZOC-MRXNPFEDSA-N 319961 3-(5-Ethyl-1,3-thiazol-2-yl)-N-[(1R)-1-(6-methylpyridazin-3-yl)ethyl]-5-(tetrahydro-2H-pyran-4-yloxy)benzamide::US10174016, Example 128::US10202369, Example 128::US10472354, Example 128 P2X purinoceptor 3 Homo sapiens 10.00 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319961 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319961&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397510 384223241 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632252 CCc1cnc(s1)-c1cc(OC2CCOCC2)cc(c1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C24H25F3N4O3S/c1-3-20-13-28-22(35-20)16-8-15(9-19(10-16)34-18-4-6-33-7-5-18)21(32)31-14(2)17-11-29-23(30-12-17)24(25,26)27/h8-14,18H,3-7H2,1-2H3,(H,31,32)/t14-/m1/s1 HAECKPIYFMDTPM-CQSZACIVSA-N 319962 3-(5-Ethyl-1,3-thiazol-2-yl)-5-(tetrahydro-2H-pyran-4-yloxy)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 129::US10202369, Example 129::US10472354, Example 129 P2X purinoceptor 3 Homo sapiens 3.00 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319962 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319962&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397362 384223242 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632254 C[C@@H](NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1cnc(C)nc1 InChI=1S/C22H24N4O3S/c1-13-9-25-22(30-13)17-6-16(7-20(8-17)29-19-4-5-28-12-19)21(27)26-14(2)18-10-23-15(3)24-11-18/h6-11,14,19H,4-5,12H2,1-3H3,(H,26,27)/t14-,19+/m1/s1 RHVHBKMOULQMJQ-KUHUBIRLSA-N 319963 N-[(1R)-1-(2-Methylpyrimidin-5-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(3S)-tetrahydrofuran-3-yloxy]benzamide::US10174016, Example 130::US10202369, Example 130::US10472354, Example 130 P2X purinoceptor 3 Homo sapiens 74.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319963 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319963&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397599 384223243 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632256 C[C@@H](NC(=O)c1cc(Oc2ccc(C)nc2)cc(c1)-c1ncc(C)s1)c1cnc(C)cn1 InChI=1S/C24H23N5O2S/c1-14-5-6-20(12-25-14)31-21-8-18(7-19(9-21)24-28-11-16(3)32-24)23(30)29-17(4)22-13-26-15(2)10-27-22/h5-13,17H,1-4H3,(H,29,30)/t17-/m1/s1 PZARJLLATJAKMG-QGZVFWFLSA-N 319964 N-[(1R)-1-(5-methylpyrazin-2-yl)ethyl]-3-[(6-methylpyridin-3-yl)oxy]-5-(5-methyl-1,3-thiazol-2-yl)benzamide::US10174016, Example 131::US10202369, Example 131::US10472354, Example 131 P2X purinoceptor 3 Homo sapiens 134 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319964 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319964&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397434 384223244 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625464 C[C@@H](NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F InChI=1S/C23H23F3N4O3S/c1-13-12-27-22(34-13)16-9-15(10-18(11-16)33-17-5-7-32-8-6-17)21(31)28-14(2)19-3-4-20(30-29-19)23(24,25)26/h3-4,9-12,14,17H,5-8H2,1-2H3,(H,28,31)/t14-/m1/s1 RJKHHNIHJKFMMR-CQSZACIVSA-N 319922 3-(5-Methyl- 1,3-thiazol-2- yl)-5- (tetrahydro- 2H-pyran-4- yloxy)-N- {(1R)-1-[6- (trifluoromethyl) pyridazin- 3-yl]ethyl} benzamide::US10174016, Example 89::US10202369, Example 89::US10472354, Example 89 P2X purinoceptor 3 Homo sapiens 11.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319922 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319922&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397595 384223202 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625466 CC[C@@H](NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H25F3N4O3S/c1-3-20(17-12-29-23(30-13-17)24(25,26)27)31-21(32)15-8-16(22-28-11-14(2)35-22)10-19(9-15)34-18-4-6-33-7-5-18/h8-13,18,20H,3-7H2,1-2H3,(H,31,32)/t20-/m1/s1 ULSBLOPPTNALIT-HXUWFJFHSA-N 319923 3-(5-Methyl- 1,3-thiazol-2- yl)-5- (tetrahydro- 2H-pyran-4- yloxy)-N-{(1R)- 1-[2- (trifluorometh- yl)pyrimidin-5- yl]propyl}benz- amide::US10174016, Example 90::US10202369, Example 90::US10472354, Example 90 P2X purinoceptor 3 Homo sapiens 111 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319923 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319923&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397769 384223203 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625468 C[C@@H](NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(C)s1)c1ccc(C)nc1 InChI=1S/C24H27N3O3S/c1-15-4-5-18(14-25-15)17(3)27-23(28)19-10-20(24-26-13-16(2)31-24)12-22(11-19)30-21-6-8-29-9-7-21/h4-5,10-14,17,21H,6-9H2,1-3H3,(H,27,28)/t17-/m1/s1 VKTBTGUHIBZLBJ-QGZVFWFLSA-N 319924 N-[(1R)-1-(6- Methylpyridin- 3-yl)ethyl]-3- (5-methyl-1,3- thiazol-2-yl)-5- (tetrahydro- 2H-pyran-4- yloxy)benzamide::US10174016, Example 91::US10202369, Example 91::US10472354, Example 91 P2X purinoceptor 3 Homo sapiens 19.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319924 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319924&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397502 384223204 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625470 C[C@@H](NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(C)s1)c1nnc(C)s1 InChI=1S/C21H24N4O3S2/c1-12-11-22-21(29-12)16-8-15(9-18(10-16)28-17-4-6-27-7-5-17)19(26)23-13(2)20-25-24-14(3)30-20/h8-11,13,17H,4-7H2,1-3H3,(H,23,26)/t13-/m1/s1 GHXRECQLMZGPIV-CYBMUJFWSA-N 319925 N-[(1R)-1-(5- Methyl-1,3,4- thiadiazol-2- yl)ethyl]-3-(5- methyl-1,3- thiazol-2-yl)-5- (tetrahydro- 2H-pyran-4- yloxy)benzamide::US10174016, Example 92::US10202369, Example 92::US10472354, Example 92 P2X purinoceptor 3 Homo sapiens 24.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319925 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319925&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397542 384223205 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625472 Cc1cnc(s1)-c1cc(OCC2CCOCC2)cc(c1)C(=O)NCc1ccc(C)nn1 InChI=1S/C23H26N4O3S/c1-15-3-4-20(27-26-15)13-24-22(28)18-9-19(23-25-12-16(2)31-23)11-21(10-18)30-14-17-5-7-29-8-6-17/h3-4,9-12,17H,5-8,13-14H2,1-2H3,(H,24,28) QOXIPNMWVVZPOQ-UHFFFAOYSA-N 319926 N-[(6- Methyl- pyridazin-3- yl)methyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5- (tetrahydro- 2H-pyran-4- ylmethoxy) benzamide::US10174016, Example 93::US10202369, Example 93::US10472354, Example 93 P2X purinoceptor 3 Homo sapiens 8.00 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319926 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319926&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397788 384223206 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625474 C[C@@H](NC(=O)c1cc(OCC2CCOCC2)cc(c1)-c1ncc(C)s1)c1cnc(C)cn1 InChI=1S/C24H28N4O3S/c1-15-11-26-22(13-25-15)17(3)28-23(29)19-8-20(24-27-12-16(2)32-24)10-21(9-19)31-14-18-4-6-30-7-5-18/h8-13,17-18H,4-7,14H2,1-3H3,(H,28,29)/t17-/m1/s1 HCAZTDIYUNBLAC-QGZVFWFLSA-N 319927 N-[(1R)-1-(5- Methylpyrazin- 2-yl)ethyl]- 3-(5-methyl- 1,3-thiazol-2- yl)-5- (tetrahydro- 2H-pyran-4- ylmethoxy) benzamide::US10174016, Example 94::US10202369, Example 94::US10472354, Example 94 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319927 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319927&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397604 384223207 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625476 CC(NC(=O)c1cc(OCC2CCOCC2)cc(c1)-c1ncc(C)s1)c1ncc(Cl)cc1F InChI=1S/C24H25ClFN3O3S/c1-14-11-28-24(33-14)18-7-17(8-20(9-18)32-13-16-3-5-31-6-4-16)23(30)29-15(2)22-21(26)10-19(25)12-27-22/h7-12,15-16H,3-6,13H2,1-2H3,(H,29,30) WLBXKEKEIMKGRV-UHFFFAOYSA-N 319928 N-[1-(5- Chloro-3- fluoropyridin- 2-yl)ethyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5- (tetrahydro- 2H-pyran--4- ylmethoxy) benzamide::US10174016, Example 95::US10202369, Example 95::US10472354, Example 95 P2X purinoceptor 3 Homo sapiens 2.00 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319928 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319928&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397656 384223208 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625478 CC(NC(=O)c1cc(OCC2CCOCC2)cc(c1)-c1ncc(C)s1)c1ncc(F)cc1Cl InChI=1S/C24H25ClFN3O3S/c1-14-11-28-24(33-14)18-7-17(8-20(9-18)32-13-16-3-5-31-6-4-16)23(30)29-15(2)22-21(25)10-19(26)12-27-22/h7-12,15-16H,3-6,13H2,1-2H3,(H,29,30) YAVBCOZWMZVERS-UHFFFAOYSA-N 319929 N-[1-(3- Chloro-5- fluoropyridin- 2-yl)ethyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5- (tetrahydro- 2H-pyran-4- ylmethoxy) benzamide::US10174016, Example 96::US10202369, Example 96::US10472354, Example 96 P2X purinoceptor 3 Homo sapiens 18.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319929 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319929&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397482 384223209 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625480 Cc1cnc(s1)-c1cc(OCC2CCOCC2)cc(c1)C(=O)NCc1cnc(C)cn1 InChI=1S/C23H26N4O3S/c1-15-10-25-20(12-24-15)13-26-22(28)18-7-19(23-27-11-16(2)31-23)9-21(8-18)30-14-17-3-5-29-6-4-17/h7-12,17H,3-6,13-14H2,1-2H3,(H,26,28) VSGRXICPAXTBHX-UHFFFAOYSA-N 319930 N-[(5- Methylpyrazin- 2- yl)methyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5- (tetrahydro- 2H-pyran-4- ylmethoxy) benzamide::US10174016, Example 97::US10202369, Example 97::US10472354, Example 97 P2X purinoceptor 3 Homo sapiens 15.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319930 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319930&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397814 384223210 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625482 C[C@@H](NC(=O)c1cc(OCC2CCOCC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H25F3N4O3S/c1-14-10-28-22(35-14)18-7-17(8-20(9-18)34-13-16-3-5-33-6-4-16)21(32)31-15(2)19-11-29-23(30-12-19)24(25,26)27/h7-12,15-16H,3-6,13H2,1-2H3,(H,31,32)/t15-/m1/s1 MBJQALPRFLKOPN-OAHLLOKOSA-N 319931 3-(5-Methyl- 1,3-thiazol-2- yl)-5- (tetrahydro- 2H-pyran-4- ylmethoxy)- N-[(1R)-1-[2- (trifluorometh- yl)pyrimidin- 5- yl]ethyl] benzamide::US10174016, Example 98::US10202369, Example 98::US10472354, Example 98 P2X purinoceptor 3 Homo sapiens 1.000 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319931 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319931&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397231 384223211 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625484 C[C@@H](NC(=O)c1cc(OCC2CCOCC2)cc(c1)-c1ncc(C)s1)c1ccc(C)nn1 InChI=1S/C24H28N4O3S/c1-15-4-5-22(28-27-15)17(3)26-23(29)19-10-20(24-25-13-16(2)32-24)12-21(11-19)31-14-18-6-8-30-9-7-18/h4-5,10-13,17-18H,6-9,14H2,1-3H3,(H,26,29)/t17-/m1/s1 FNFCPAXHCILJLE-QGZVFWFLSA-N 319932 N-[(1R)-1-(6- Methyl- pyridazin-3- yl)ethyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5- (tetrahydro- 2H-pyran-4- ylmethoxy) benzamide::US10174016, Example 99::US10202369, Example 99::US10472354, Example 99 P2X purinoceptor 3 Homo sapiens 2.00 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319932 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319932&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397399 384223212 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625486 C[C@@H](NC(=O)c1cc(Oc2ccnc(C)c2)cc(c1)-c1ncc(C)s1)c1ccc(C)nn1 InChI=1S/C24H23N5O2S/c1-14-5-6-22(29-28-14)17(4)27-23(30)18-10-19(24-26-13-16(3)32-24)12-21(11-18)31-20-7-8-25-15(2)9-20/h5-13,17H,1-4H3,(H,27,30)/t17-/m1/s1 AOJXRFXYSRJHEO-QGZVFWFLSA-N 319933 N-[(1R)-1-(6- Methyl- pyridazin-3- yl)ethyl]-3- [(2- methylpyridin- 4-yl)oxy]-5- (5-methyl- 1,3-thiazol-2- yl)benzamide::US10174016, Example 100::US10202369, Example 100::US10472354, Example 100 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319933 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319933&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397202 384223213 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625488 Cc1cnc(s1)-c1cc(Oc2ccnc(C)c2)cc(c1)C(=O)NCc1ccc(C)nn1 InChI=1S/C23H21N5O2S/c1-14-4-5-19(28-27-14)13-25-22(29)17-9-18(23-26-12-16(3)31-23)11-21(10-17)30-20-6-7-24-15(2)8-20/h4-12H,13H2,1-3H3,(H,25,29) XCSQCNBYINKWNK-UHFFFAOYSA-N 319934 N-[(6- Methyl- pyridazin-3- yl)methyl]-3- [(2- methylpyridin- 4-yl)oxy]-5- (5-methyl- 1,3-thiazol-2- yl)benzamide::US10174016, Example 101::US10202369, Example 101::US10472354, Example 101 P2X purinoceptor 3 Homo sapiens 15.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319934 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319934&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397744 384223214 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625490 C[C@@H](NC(=O)c1cc(Oc2ccnc(C)c2)cc(c1)-c1ncc(C)s1)c1cnc(C)cn1 InChI=1S/C24H23N5O2S/c1-14-7-20(5-6-25-14)31-21-9-18(8-19(10-21)24-28-12-16(3)32-24)23(30)29-17(4)22-13-26-15(2)11-27-22/h5-13,17H,1-4H3,(H,29,30)/t17-/m1/s1 QEKNBUCJINMCOL-QGZVFWFLSA-N 319935 N-[(1R)-1-(5- Methylpyrazin- 2-yl)ethyl]- 3-[(2- methylpyridin- 4-yl)oxy]-5- (5-methyl- 1,3-thiazol-2- yl)benzamide::US10174016, Example 102::US10202369, Example 102::US10472354, Example 102 P2X purinoceptor 3 Homo sapiens 10.00 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319935 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319935&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397697 384223215 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625492 C[C@@H](NC(=O)c1cc(Oc2ccnc(C)c2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H20F3N5O2S/c1-13-6-19(4-5-28-13)34-20-8-16(7-17(9-20)22-29-10-14(2)35-22)21(33)32-15(3)18-11-30-23(31-12-18)24(25,26)27/h4-12,15H,1-3H3,(H,32,33)/t15-/m1/s1 JXFGKHKXOUTTKZ-OAHLLOKOSA-N 319936 3-[(2- Methylpyridin- 4-yl)oxy]-5- (5-methyl- 1,3-thiazol-2- yl)-N-{(1R)-1- [2- (trifluorometh- yl)pyrimidin- 5- yl]ethyl} benzamide::US10174016, Example 103::US10202369, Example 103::US10472354, Example 103 P2X purinoceptor 3 Homo sapiens 2.00 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319936 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319936&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397214 384223216 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625494 Cc1cnc(s1)-c1cc(Oc2ccnc(C)c2)cc(c1)C(=O)NCc1cnc(C)cn1 InChI=1S/C23H21N5O2S/c1-14-6-20(4-5-24-14)30-21-8-17(7-18(9-21)23-28-11-16(3)31-23)22(29)27-13-19-12-25-15(2)10-26-19/h4-12H,13H2,1-3H3,(H,27,29) FHRXECCRJLFVTP-UHFFFAOYSA-N 319937 N-[(5- Methylpyrazin- 2- yl)methyl]-3- [(2- methylpyridin- 4-yl)oxy]-5- (5-methyl- 1,3-thiazol-2- yl)benzamide::US10174016, Example 104::US10202369, Example 104::US10472354, Example 104 P2X purinoceptor 3 Homo sapiens 51.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319937 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319937&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397645 384223217 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625496 C[C@@H](NC(=O)c1cc(Oc2ccnc(C)c2)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F InChI=1S/C24H20F3N5O2S/c1-13-8-18(6-7-28-13)34-19-10-16(9-17(11-19)23-29-12-14(2)35-23)22(33)30-15(3)20-4-5-21(32-31-20)24(25,26)27/h4-12,15H,1-3H3,(H,30,33)/t15-/m1/s1 DZQXNDYGTRQHHO-OAHLLOKOSA-N 319938 3-[(2- Methylpyridin- 4-yl)oxy]-5- (5-methyl- 1,3-thiazol-2- yl)-N-{(1R)-1- [6- (trifluorometh- yl)pyridazin- 3- yl]ethyl} benzamide::US10174016, Example 105::US10202369, Example 105::US10472354, Example 105 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319938 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319938&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397847 384223218 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625498 C[C@@H](NC(=O)c1cc(Oc2ccnc(C)c2)cc(c1)-c1ncc(C)s1)c1cnc(C)nc1 InChI=1S/C24H23N5O2S/c1-14-7-21(5-6-25-14)31-22-9-18(8-19(10-22)24-28-11-15(2)32-24)23(30)29-16(3)20-12-26-17(4)27-13-20/h5-13,16H,1-4H3,(H,29,30)/t16-/m1/s1 AVOXIOANORGYFZ-MRXNPFEDSA-N 319939 3-[(2-methylpyridin-4-yl)oxy]-N-[(1R)-1-(2-methylpyrimidin-5-yl)ethyl]-5-(5-methyl-1,3-thiazol-2-yl)benzamide::US10174016, Example 106::US10202369, Example 106::US10472354, Example 106 P2X purinoceptor 3 Homo sapiens 16.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319939 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319939&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397227 384223219 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625500 C[C@@H](NC(=O)c1cc(Oc2ccnc(C)c2)cc(c1)-c1ncc(C)s1)c1ccc(C)nc1 InChI=1S/C25H24N4O2S/c1-15-5-6-19(14-27-15)18(4)29-24(30)20-10-21(25-28-13-17(3)32-25)12-23(11-20)31-22-7-8-26-16(2)9-22/h5-14,18H,1-4H3,(H,29,30)/t18-/m1/s1 PNIOXTPFLIQKJT-GOSISDBHSA-N 319940 N-[(1R)-1-(6- Methylpyridin- 3-yl)ethyl]- 3-[(2- methylpyridin- 4-yl)oxy]-5- (5-methyl- 1,3-thiazol-2- yl)benzamide::US10174016, Example 107::US10202369, Example 107::US10472354, Example 107 P2X purinoceptor 3 Homo sapiens 9.00 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319940 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319940&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397329 384223220 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625502 C[C@@H](NC(=O)c1cc(Oc2ccc(C)nc2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H20F3N5O2S/c1-13-4-5-19(12-28-13)34-20-7-16(6-17(8-20)22-29-9-14(2)35-22)21(33)32-15(3)18-10-30-23(31-11-18)24(25,26)27/h4-12,15H,1-3H3,(H,32,33)/t15-/m1/s1 ASXORIIIQIGPLA-OAHLLOKOSA-N 319941 3-[(6-Methylpyridin-3-yl)oxy]-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 108::US10202369, Example 108::US10472354, Example 108 P2X purinoceptor 3 Homo sapiens 11.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319941 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319941&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397249 384223221 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625504 C[C@@H](NC(=O)c1cc(Oc2nnc(C)s2)cc(c1)-c1ncc(C)s1)c1cnc(C)cn1 InChI=1S/C21H20N6O2S2/c1-11-8-23-18(10-22-11)13(3)25-19(28)15-5-16(20-24-9-12(2)30-20)7-17(6-15)29-21-27-26-14(4)31-21/h5-10,13H,1-4H3,(H,25,28)/t13-/m1/s1 SHPJQOXSFBKQMY-CYBMUJFWSA-N 319942 N-[(1R)-1-(5- Methylpyrazin- 2-yl)ethyl]-3- [(5-methyl- 1,3,4- thiadiazol-2- yl)oxy]-5-(5- methyl-1,3- thiazol-2- yl)benzamide::US10174016, Example 109::US10202369, Example 109::US10472354, Example 109 P2X purinoceptor 3 Homo sapiens 235 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319942 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319942&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397425 384223222 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625506 C[C@@H](NC(=O)c1cc(Oc2nnc(C)s2)cc(c1)-c1ncc(C)s1)c1ccc(C)nn1 InChI=1S/C21H20N6O2S2/c1-11-5-6-18(26-24-11)13(3)23-19(28)15-7-16(20-22-10-12(2)30-20)9-17(8-15)29-21-27-25-14(4)31-21/h5-10,13H,1-4H3,(H,23,28)/t13-/m1/s1 YBUIRLYLJALMRA-CYBMUJFWSA-N 319943 N-[(1R)-1-(6- Methylpyridazin- 3-yl)ethyl]- 3-[(5-methyl- 1,3,4- thiadiazol-2- yl)oxy]-5-(5- methyl-1,3- thiazol-2- yl)benzamide::US10174016, Example 110::US10202369, Example 110::US10472354, Example 110 P2X purinoceptor 3 Homo sapiens 114 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319943 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319943&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397265 384223223 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625508 C[C@@H](NC(=O)c1cc(Oc2nnc(C)s2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C21H17F3N6O2S2/c1-10-7-25-18(33-10)14-4-13(5-16(6-14)32-20-30-29-12(3)34-20)17(31)28-11(2)15-8-26-19(27-9-15)21(22,23)24/h4-9,11H,1-3H3,(H,28,31)/t11-/m1/s1 FIVDAXBJTLXBHI-LLVKDONJSA-N 319944 3-[(5-Methyl- 1,3,4- thiadiazol-2- yl)oxy]-5-(5- methyl-1,3- thiazol-2-yl)- N-[(1R)-1-[2- (trifluorometh- yl)pyrimidin-5- yl]ethyl] benzamide::US10174016, Example 111::US10202369, Example 111::US10472354, Example 111 P2X purinoceptor 3 Homo sapiens 16.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319944 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319944&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397223 384223224 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625510 C[C@@H](NC(=O)c1cc(Oc2nccs2)cc(c1)-c1ncc(C)s1)c1cnc(C)cn1 InChI=1S/C21H19N5O2S2/c1-12-9-24-18(11-23-12)14(3)26-19(27)15-6-16(20-25-10-13(2)30-20)8-17(7-15)28-21-22-4-5-29-21/h4-11,14H,1-3H3,(H,26,27)/t14-/m1/s1 QJIZPYNDSFDLFQ-CQSZACIVSA-N 319945 N-[(1R)-1-(5- Methylpyrazin- 2-yl)ethyl]-3- (5-methyl-1,3- thiazol-2-yl)-5- (1,3-thiazol-2- yloxy)benzamide::US10174016, Example 112::US10472354, Example 112 P2X purinoceptor 3 Homo sapiens 61.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319945 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319945&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397232 384223225 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625512 C[C@@H](NC(=O)c1cc(Oc2nccs2)cc(c1)-c1ncc(C)s1)c1ccc(C)nn1 InChI=1S/C21H19N5O2S2/c1-12-4-5-18(26-25-12)14(3)24-19(27)15-8-16(20-23-11-13(2)30-20)10-17(9-15)28-21-22-6-7-29-21/h4-11,14H,1-3H3,(H,24,27)/t14-/m1/s1 KTZHJRKMBNLACT-CQSZACIVSA-N 319946 N-[(1R)-1-(6- Methylpyridazin- 3-yl)ethyl]- 3-(5-methyl- 1,3-thiazol-2- yl)-5-(1,3- thiazol-2- yloxy)benzamide::US10174016, Example 113::US10202369, Example 113::US10472354, Example 113 P2X purinoceptor 3 Homo sapiens 43.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319946 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319946&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397679 384223226 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625514 C[C@@H](NC(=O)c1cc(Oc2nccs2)cc(c1)-c1ncc(C)s1)c1ccc(C)nc1 InChI=1S/C22H20N4O2S2/c1-13-4-5-16(12-24-13)15(3)26-20(27)17-8-18(21-25-11-14(2)30-21)10-19(9-17)28-22-23-6-7-29-22/h4-12,15H,1-3H3,(H,26,27)/t15-/m1/s1 WJNIKDPPMLYZOS-OAHLLOKOSA-N 319947 N-[(1R)-1-(6- Methylpyridin- 3-yl)ethyl]-3- (5-methyl-1,3- thiazol-2-yl)-5- (1,3-thiazol-2- yloxy)benzamide::US10174016, Example 114::US10202369, Example 114::US10472354, Example 114 P2X purinoceptor 3 Homo sapiens 38.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319947 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319947&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397612 384223227 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625516 COC(C)(C)COc1cc(cc(c1)-c1ncc(Cl)s1)C(=O)N[C@H](C)c1ccc(Cl)cn1 InChI=1S/C22H23Cl2N3O3S/c1-13(18-6-5-16(23)10-25-18)27-20(28)14-7-15(21-26-11-19(24)31-21)9-17(8-14)30-12-22(2,3)29-4/h5-11,13H,12H2,1-4H3,(H,27,28)/t13-/m1/s1 MHZRDUGBKYAKKB-CYBMUJFWSA-N 319948 N-[(1R)-1-(5-Chloropyridin-2-yl)ethyl]-3-(5-chloro-1,3-thiazol-2-yl)-5-(2-methoxy-2-methylpropoxy)benzamide::US10174016, Example 115::US10202369, Example 115::US10472354, Example 115 P2X purinoceptor 3 Homo sapiens 15.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319948 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319948&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397201 384223228 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625518 COC(C)(C)COc1cc(cc(c1)-c1ncc(Cl)s1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C22H22ClF3N4O3S/c1-12(15-8-28-20(29-9-15)22(24,25)26)30-18(31)13-5-14(19-27-10-17(23)34-19)7-16(6-13)33-11-21(2,3)32-4/h5-10,12H,11H2,1-4H3,(H,30,31)/t12-/m1/s1 QSHVLLWXZBADRN-GFCCVEGCSA-N 319949 3-(5-Chloro-1,3-thiazol-2-yl)-5-(2-methoxy-2-methylpropoxy)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 116::US10202369, Example 116::US10472354, Example 116 P2X purinoceptor 3 Homo sapiens 210 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319949 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319949&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397235 384223229 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625520 COC(C)(C)COc1cc(cc(c1)-c1ncc(Cl)s1)C(=O)N[C@H](C)c1cnc(C)cn1 InChI=1S/C22H25ClN4O3S/c1-13-9-25-18(10-24-13)14(2)27-20(28)15-6-16(21-26-11-19(23)31-21)8-17(7-15)30-12-22(3,4)29-5/h6-11,14H,12H2,1-5H3,(H,27,28)/t14-/m1/s1 IVUVTQZOIPAQFU-CQSZACIVSA-N 319950 3-(5-Chloro-1,3-thiazol-2-yl)-5-(2-methoxy-2-methylpropoxy)-N-[(1R)-1-(5-methylpyrazin-2-yl)ethyl]benzamide::US10174016, Example 117::US10202369, Example 117::US10472354, Example 117 P2X purinoceptor 3 Homo sapiens 36.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319950 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319950&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397711 384223230 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625522 Cc1ccc(CNC(=O)c2cc(OCC3CCOCC3)cc(c2)-c2ncc(s2)C(F)(F)F)nn1 InChI=1S/C23H23F3N4O3S/c1-14-2-3-18(30-29-14)11-27-21(31)16-8-17(22-28-12-20(34-22)23(24,25)26)10-19(9-16)33-13-15-4-6-32-7-5-15/h2-3,8-10,12,15H,4-7,11,13H2,1H3,(H,27,31) JVFRARFSFIRWBD-UHFFFAOYSA-N 319951 N-[(6-Methylpyridazin-3-yl)methyl]-3-(tetrahydro-2H-pyran-4-ylmethoxy)-5-[5-(trifluoromethyl)-1,3-thiazol-2-yl]benzamide::US10174016, Example 118::US10202369, Example 118::US10472354, Example 118 P2X purinoceptor 3 Homo sapiens 198 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319951 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319951&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397366 384223231 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625524 Cc1ccc(CNC(=O)c2cc(OCC3CCOCC3)cc(c2)-c2ncc(s2)C2CCC2)nn1 InChI=1S/C26H30N4O3S/c1-17-5-6-22(30-29-17)14-27-25(31)20-11-21(26-28-15-24(34-26)19-3-2-4-19)13-23(12-20)33-16-18-7-9-32-10-8-18/h5-6,11-13,15,18-19H,2-4,7-10,14,16H2,1H3,(H,27,31) UIEYRDUAWDAEID-UHFFFAOYSA-N 319952 3-(5-Cyclobutyl-1,3-thiazol-2-yl)-N-[(6-methylpyridazin-3-yl)methyl]-5-(tetrahydro-2H-pyran-4-ylmethoxy)benzamide::US10174016, Example 119::US10202369, Example 119::US10472354, Example 119 P2X purinoceptor 3 Homo sapiens 24.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319952 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319952&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397447 384223232 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632008 C[C@@H](NC(=O)c1cc(OCC2CC2)cc(c1)-c1ncc(C)s1)c1nnc(C)s1 InChI=1S/C20H22N4O2S2/c1-11-9-21-20(27-11)16-6-15(7-17(8-16)26-10-14-4-5-14)18(25)22-12(2)19-24-23-13(3)28-19/h6-9,12,14H,4-5,10H2,1-3H3,(H,22,25)/t12-/m1/s1 QOCVVHCSVZQPAR-GFCCVEGCSA-N 319840 3-(Cyclopropylmethoxy)-N-[(1R)-1-(5-methyl-1,3,4-thiadiazol-2-yl)ethyl]-5-(5-methyl-1,3-thiazol-2-yl)benzamide::US10174016, Example 7::US10202369, Example 7::US10472354, Example 7 P2X purinoceptor 3 Homo sapiens 8.00 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319840 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319840&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397154 384223120 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632010 C[C@@H](NC(=O)c1cc(OCC2CC2)cc(c1)-c1ncc(C)s1)c1ccc(C)nn1 InChI=1S/C22H24N4O2S/c1-13-4-7-20(26-25-13)15(3)24-21(27)17-8-18(22-23-11-14(2)29-22)10-19(9-17)28-12-16-5-6-16/h4,7-11,15-16H,5-6,12H2,1-3H3,(H,24,27)/t15-/m1/s1 ZZPHBEIBURIANJ-OAHLLOKOSA-N 319841 3-(Cyclopropylmethoxy)-N-[(1R)-1-(6-methylpyridazin-3-yl)ethyl]-5-(5-methyl-1,3-thiazol-2-yl)benzamide::US10174016, Example 8::US10202369, Example 8::US10472354, Example 8 P2X purinoceptor 3 Homo sapiens 3.00 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319841 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319841&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397204 384223121 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632012 C[C@@H](NC(=O)c1cc(OCC2CC2)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F InChI=1S/C22H21F3N4O2S/c1-12-10-26-21(32-12)16-7-15(8-17(9-16)31-11-14-3-4-14)20(30)27-13(2)18-5-6-19(29-28-18)22(23,24)25/h5-10,13-14H,3-4,11H2,1-2H3,(H,27,30)/t13-/m1/s1 FDEHTNMFMQMRCT-CYBMUJFWSA-N 319842 3-(Cyclopropylmethoxy)-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[6-(trifluoromethyl)pyridazin-3-yl]ethyl}benzamide::US10174016, Example 9::US10202369, Example 9::US10472354, Example 9 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319842 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319842&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397573 384223122 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632014 C[C@@H](NC(=O)c1cc(OCC2CC2)cc(c1)-c1ncc(C)s1)c1cnc(C)nc1 InChI=1S/C22H24N4O2S/c1-13-9-25-22(29-13)18-6-17(7-20(8-18)28-12-16-4-5-16)21(27)26-14(2)19-10-23-15(3)24-11-19/h6-11,14,16H,4-5,12H2,1-3H3,(H,26,27)/t14-/m1/s1 HEHYSAYIHLPEGC-CQSZACIVSA-N 319843 3-(Cyclopropylmethoxy)-N-[(1R)-1-(2-methylpyrimidin-5-yl)ethyl]-5-(5-methyl-1,3-thiazol-2-yl)benzamide::US10174016, Example 10::US10202369, Example 10::US10472354, Example 10 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319843 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319843&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397702 384223123 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632016 C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C22H21F3N4O3S/c1-12-8-26-20(33-12)15-5-14(6-18(7-15)32-17-3-4-31-11-17)19(30)29-13(2)16-9-27-21(28-10-16)22(23,24)25/h5-10,13,17H,3-4,11H2,1-2H3,(H,29,30)/t13-,17-/m1/s1 GTQPEQGDLVSFJO-CXAGYDPISA-N 319844 3-(5-Methyl-1,3-thiazol-2-yl)-5-[(3R)-tetrahydrofuran-3-yloxy]-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 11::US10202369, Example 11::US10472354, Example 291 P2X purinoceptor 3 Homo sapiens 8.00 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319844 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319844&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397587 384223124 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632018 Cc1cnc(s1)-c1cc(O[C@@H]2CCOC2)cc(c1)C(=O)NCc1cnc(C)cn1 InChI=1S/C21H22N4O3S/c1-13-8-23-17(10-22-13)11-24-20(26)15-5-16(21-25-9-14(2)29-21)7-19(6-15)28-18-3-4-27-12-18/h5-10,18H,3-4,11-12H2,1-2H3,(H,24,26)/t18-/m1/s1 SKCSTCBULJTUPE-GOSISDBHSA-N 319845 N-[(5-methylpyrazin-2-yl)methyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(3R)-tetrahydrofuran-3-yloxy]benzamide::US10174016, Example 12::US10202369, Example 12 P2X purinoceptor 3 Homo sapiens 283 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319845 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319845&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397167 384223125 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632020 CC(NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ncc(F)cc1Cl InChI=1S/C22H21ClFN3O3S/c1-12-9-26-22(31-12)15-5-14(6-18(7-15)30-17-3-4-29-11-17)21(28)27-13(2)20-19(23)8-16(24)10-25-20/h5-10,13,17H,3-4,11H2,1-2H3,(H,27,28)/t13?,17-/m1/s1 YETTUNLUNMEXML-LRHAYUFXSA-N 319846 N-[1-(3-chloro-5-fluoropyridin-2-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(3R)-tetrahydrofuran-3-yloxy]benzamide::US10174016, Example 13::US10202369, Example 13::US10472354, Example 13 P2X purinoceptor 3 Homo sapiens 21.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319846 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319846&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397669 384223126 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632022 CC(NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ncc(Cl)cc1F InChI=1S/C22H21ClFN3O3S/c1-12-9-26-22(31-12)15-5-14(6-18(7-15)30-17-3-4-29-11-17)21(28)27-13(2)20-19(24)8-16(23)10-25-20/h5-10,13,17H,3-4,11H2,1-2H3,(H,27,28)/t13?,17-/m1/s1 DLODQDUFIVUCLQ-LRHAYUFXSA-N 319847 N-[1-(5-chloro-3-fluoropyridin-2-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(3R)-tetrahydrofuran-3-yloxy]benzamide::US10174016, Example 14::US10202369, Example 14::US10472354, Example 14 P2X purinoceptor 3 Homo sapiens 8.00 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319847 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319847&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397583 384223127 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632024 C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ccc(Cl)cn1 InChI=1S/C22H22ClN3O3S/c1-13-10-25-22(30-13)16-7-15(8-19(9-16)29-18-5-6-28-12-18)21(27)26-14(2)20-4-3-17(23)11-24-20/h3-4,7-11,14,18H,5-6,12H2,1-2H3,(H,26,27)/t14-,18-/m1/s1 DURBVTDNVKUTOV-RDTXWAMCSA-N 319848 N-[(1R)-1-(5-chloropyridin-2-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(3R)-tetrahydrofuran-3-yloxy]benzamide::US10174016, Example 15::US10202369, Example 15::US10472354, Example 15 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319848 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319848&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397630 384223128 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632026 C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1cnc(C)cn1 InChI=1S/C22H24N4O3S/c1-13-9-24-20(11-23-13)15(3)26-21(27)16-6-17(22-25-10-14(2)30-22)8-19(7-16)29-18-4-5-28-12-18/h6-11,15,18H,4-5,12H2,1-3H3,(H,26,27)/t15-,18-/m1/s1 GGLGXVJJVCGSBA-CRAIPNDOSA-N 319849 N-[(1R)-1-(5-methylpyrazin-2-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(3R)-tetrahydrofuran-3-yloxy]benzamide::US10174016, Example 16::US10202369, Example 16::US10472354, Example 16 P2X purinoceptor 3 Homo sapiens 38.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319849 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319849&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397267 384223129 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632028 Cc1cnc(s1)-c1cc(O[C@@H]2CCOC2)cc(c1)C(=O)NCc1ccc(C)nn1 InChI=1S/C21H22N4O3S/c1-13-3-4-17(25-24-13)11-22-20(26)15-7-16(21-23-10-14(2)29-21)9-19(8-15)28-18-5-6-27-12-18/h3-4,7-10,18H,5-6,11-12H2,1-2H3,(H,22,26)/t18-/m1/s1 VKRRMZCTKMLCQJ-GOSISDBHSA-N 319850 N-[(6-methylpyridazin-3-yl)methyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(3R)-tetrahydrofuran-3-yloxy]benzamide::US10174016, Example 17::US10202369, Example 17::US10472354, Example 17 P2X purinoceptor 3 Homo sapiens 35.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319850 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319850&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397146 384223130 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632030 C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ccc(C)nn1 InChI=1S/C22H24N4O3S/c1-13-4-5-20(26-25-13)15(3)24-21(27)16-8-17(22-23-11-14(2)30-22)10-19(9-16)29-18-6-7-28-12-18/h4-5,8-11,15,18H,6-7,12H2,1-3H3,(H,24,27)/t15-,18-/m1/s1 JJXMVDHMQZPOJY-CRAIPNDOSA-N 319851 N-[(1R)-1-(6-methylpyridazin-3-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(3R)-tetrahydrofuran-3-yloxy]benzamide::US10174016, Example 18::US10202369, Example 18::US10472354, Example 18 P2X purinoceptor 3 Homo sapiens 34.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319851 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319851&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397758 384223131 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632032 C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F InChI=1S/C22H21F3N4O3S/c1-12-10-26-21(33-12)15-7-14(8-17(9-15)32-16-5-6-31-11-16)20(30)27-13(2)18-3-4-19(29-28-18)22(23,24)25/h3-4,7-10,13,16H,5-6,11H2,1-2H3,(H,27,30)/t13-,16-/m1/s1 DNHMMXLROIMBSA-CZUORRHYSA-N 319852 3-(5-Methyl-1,3-thiazol-2-yl)-5-[(3R)-tetrahydrofuran-3-yloxy]-N-{(1R)-1-[6-(trifluoromethyl)pyridazin-3-yl]ethyl}benzamide::US10174016, Example 19::US10202369, Example 19::US10472354, Example 19 P2X purinoceptor 3 Homo sapiens 19.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319852 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319852&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397747 384223132 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632034 C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1nnc(C)s1 InChI=1S/C20H22N4O3S2/c1-11-9-21-20(28-11)15-6-14(7-17(8-15)27-16-4-5-26-10-16)18(25)22-12(2)19-24-23-13(3)29-19/h6-9,12,16H,4-5,10H2,1-3H3,(H,22,25)/t12-,16-/m1/s1 WVNVOAPVSAUSTP-MLGOLLRUSA-N 319853 N-[(1R)-1-(5-methyl-1,3,4-thiadiazol-2-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(3R)-tetrahydrofuran-3-yloxy]benzamide::US10174016, Example 20::US10202369, Example 20::US10472354, Example 20 P2X purinoceptor 3 Homo sapiens 35.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319853 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319853&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397835 384223133 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632036 Cc1cnc(s1)-c1cc(O[C@@H]2CCOC2)cc(c1)C(=O)NCc1ccc(nn1)C(F)(F)F InChI=1S/C21H19F3N4O3S/c1-12-9-26-20(32-12)14-6-13(7-17(8-14)31-16-4-5-30-11-16)19(29)25-10-15-2-3-18(28-27-15)21(22,23)24/h2-3,6-9,16H,4-5,10-11H2,1H3,(H,25,29)/t16-/m1/s1 YZCYRJHHBOIVER-MRXNPFEDSA-N 319854 3-(5-Methyl-1,3-thiazol-2-yl)-5-[(3R)-tetrahydrofuran-3-yloxy]-N-{[6-(trifluoromethyl)pyridazin-3-yl]methyl}benzamide::US10174016, Example 21::US10202369, Example 21::US10472354, Example 21 P2X purinoceptor 3 Homo sapiens 71.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319854 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319854&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397575 384223134 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632038 CC[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H23F3N4O3S/c1-3-19(16-10-28-22(29-11-16)23(24,25)26)30-20(31)14-6-15(21-27-9-13(2)34-21)8-18(7-14)33-17-4-5-32-12-17/h6-11,17,19H,3-5,12H2,1-2H3,(H,30,31)/t17-,19-/m1/s1 VUXDKUAYZMWTBM-IEBWSBKVSA-N 319855 3-(5-Methyl-1,3-thiazol-2-yl)-5-[(3R)-tetrahydrofuran-3-yloxy]-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]propyl}benzamide::US10174016, Example 22::US10202369, Example 22::US10472354, Example 22 P2X purinoceptor 3 Homo sapiens 132 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319855 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319855&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397246 384223135 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632040 C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1cnc(C)nc1 InChI=1S/C22H24N4O3S/c1-13-9-25-22(30-13)17-6-16(7-20(8-17)29-19-4-5-28-12-19)21(27)26-14(2)18-10-23-15(3)24-11-18/h6-11,14,19H,4-5,12H2,1-3H3,(H,26,27)/t14-,19-/m1/s1 RHVHBKMOULQMJQ-AUUYWEPGSA-N 319856 N-[(1R)-1-(2-Methylpyrimidin-5-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(3R)-tetrahydrofuran-3-yloxy]benzamide::US10174016, Example 23::US10202369, Example 23 P2X purinoceptor 3 Homo sapiens 30.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319856 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319856&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397288 384223136 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632042 C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ccc(C)nc1 InChI=1S/C23H25N3O3S/c1-14-4-5-17(12-24-14)16(3)26-22(27)18-8-19(23-25-11-15(2)30-23)10-21(9-18)29-20-6-7-28-13-20/h4-5,8-12,16,20H,6-7,13H2,1-3H3,(H,26,27)/t16-,20-/m1/s1 KGDPEGCMVCXNPY-OXQOHEQNSA-N 319857 N-[(1R)-1-(6-Methylpyridin-3-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(3R)-tetrahydrofuran-3-yloxy]benzamide::US10174016, Example 24::US10202369, Example 24 P2X purinoceptor 3 Homo sapiens 36.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319857 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319857&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397467 384223137 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632044 C[C@@H](NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ccc(C)nn1 InChI=1S/C22H24N4O3S/c1-13-4-5-20(26-25-13)15(3)24-21(27)16-8-17(22-23-11-14(2)30-22)10-19(9-16)29-18-6-7-28-12-18/h4-5,8-11,15,18H,6-7,12H2,1-3H3,(H,24,27)/t15-,18+/m1/s1 JJXMVDHMQZPOJY-QAPCUYQASA-N 319858 N-[(1R)-1-(6-Methylpyridazin-3-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(3S)-tetrahydrofuran-3-yloxy]benzamide::US10174016, Example 25::US10202369, Example 25::US10472354, Example 25 P2X purinoceptor 3 Homo sapiens 39.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319858 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319858&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397569 384223138 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632046 C[C@@H](NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C22H21F3N4O3S/c1-12-8-26-20(33-12)15-5-14(6-18(7-15)32-17-3-4-31-11-17)19(30)29-13(2)16-9-27-21(28-10-16)22(23,24)25/h5-10,13,17H,3-4,11H2,1-2H3,(H,29,30)/t13-,17+/m1/s1 GTQPEQGDLVSFJO-DYVFJYSZSA-N 319859 3-(5-Methyl-1,3-thiazol-2-yl)-5-[(3S)-tetrahydrofuran-3-yloxy]-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 26::US10202369, Example 26::US10472354, Example 26 P2X purinoceptor 3 Homo sapiens 8.00 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319859 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319859&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397418 384223139 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632048 C[C@@H](NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ccc(Cl)cn1 InChI=1S/C22H22ClN3O3S/c1-13-10-25-22(30-13)16-7-15(8-19(9-16)29-18-5-6-28-12-18)21(27)26-14(2)20-4-3-17(23)11-24-20/h3-4,7-11,14,18H,5-6,12H2,1-2H3,(H,26,27)/t14-,18+/m1/s1 DURBVTDNVKUTOV-KDOFPFPSSA-N 319860 N-[(1R)-1-(5-Chloropyridin-2-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(3S)-tetrahydrofuran-3-yloxy]benzamide::US10174016, Example 27::US10202369, Example 27::US10472354, Example 27 P2X purinoceptor 3 Homo sapiens 25.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319860 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319860&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397158 384223140 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632050 C[C@@H](NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ccc(C)cn1 InChI=1S/C23H25N3O3S/c1-14-4-5-21(24-11-14)16(3)26-22(27)17-8-18(23-25-12-15(2)30-23)10-20(9-17)29-19-6-7-28-13-19/h4-5,8-12,16,19H,6-7,13H2,1-3H3,(H,26,27)/t16-,19+/m1/s1 CFTQNAYGOFQJGD-APWZRJJASA-N 319861 N-[(1R)-1-(5-Methylpyridin-2-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(3S)-tetrahydrofuran-3-yloxy]benzamide::US10174016, Example 28::US10202369, Example 28::US10472354, Example 28 P2X purinoceptor 3 Homo sapiens 48.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319861 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319861&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397224 384223141 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632052 C[C@@H](NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1cnc(C)cn1 InChI=1S/C22H24N4O3S/c1-13-9-24-20(11-23-13)15(3)26-21(27)16-6-17(22-25-10-14(2)30-22)8-19(7-16)29-18-4-5-28-12-18/h6-11,15,18H,4-5,12H2,1-3H3,(H,26,27)/t15-,18+/m1/s1 GGLGXVJJVCGSBA-QAPCUYQASA-N 319862 N-[(1R)-1-(5-Methylpyrazin-2-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(3S)-tetrahydrofuran-3-yloxy]benzamide::US10174016, Example 29::US10472354, Example 29 P2X purinoceptor 3 Homo sapiens 79.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319862 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319862&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397726 384223142 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632054 C[C@@H](NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ccc(C)nc1 InChI=1S/C23H25N3O3S/c1-14-4-5-17(12-24-14)16(3)26-22(27)18-8-19(23-25-11-15(2)30-23)10-21(9-18)29-20-6-7-28-13-20/h4-5,8-12,16,20H,6-7,13H2,1-3H3,(H,26,27)/t16-,20+/m1/s1 KGDPEGCMVCXNPY-UZLBHIALSA-N 319863 N-[(1R)-1-(6- Methylpyridin- 3-yl)ethyl]-3- (5-methyl-1,3- thiazol-2-yl)-5- [(3S)- tetrahydrofuran- 3-yloxy] benzamide::US10174016, Example 30::US10202369, Example 30::US10472354, Example 30 P2X purinoceptor 3 Homo sapiens 38.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319863 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319863&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397828 384223143 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632056 Cc1cnc(s1)-c1cc(OCC#C)cc(c1)C(=O)NCc1ccc(C)nn1 InChI=1S/C20H18N4O2S/c1-4-7-26-18-9-15(8-16(10-18)20-22-11-14(3)27-20)19(25)21-12-17-6-5-13(2)23-24-17/h1,5-6,8-11H,7,12H2,2-3H3,(H,21,25) JDOBHPRLWOBCFP-UHFFFAOYSA-N 319864 N-[(6- Methylpyridazin- 3-yl)methyl]-3- (5-methyl-1,3- thiazol-2-yl)-5- (prop-2-yn-1- yloxy) benzamide::US10174016, Example 31::US10202369, Example 31::US10472354, Example 31 P2X purinoceptor 3 Homo sapiens 173 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319864 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319864&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397457 384223144 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632058 Cc1cnc(s1)-c1cc(OCC#C)cc(c1)C(=O)NCc1ncc(Cl)cc1F InChI=1S/C20H15ClFN3O2S/c1-3-4-27-16-6-13(5-14(7-16)20-25-9-12(2)28-20)19(26)24-11-18-17(22)8-15(21)10-23-18/h1,5-10H,4,11H2,2H3,(H,24,26) VKJAMZXKIQCHSG-UHFFFAOYSA-N 322220 N-[(5-Chloro-3- fluoropyridin-2- yl)methyl]-3-(5- methyl-1,3- thiazol-2-yl)-5- (prop-2-yn-1- yloxy) benzamide::US10183937, Example 32::US10202369, Example 32::US10472354, Example 32 P2X purinoceptor 3 Homo sapiens 24.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322220 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322220&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397185 384225297 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632060 C[C@@H](NC(=O)c1cc(OCC#C)cc(c1)-c1ncc(C)s1)c1ccc(C)nc1 InChI=1S/C22H21N3O2S/c1-5-8-27-20-10-18(9-19(11-20)22-24-12-15(3)28-22)21(26)25-16(4)17-7-6-14(2)23-13-17/h1,6-7,9-13,16H,8H2,2-4H3,(H,25,26)/t16-/m1/s1 ZCHZUISZWKOUTB-MRXNPFEDSA-N 319866 N-[(1R)-1-(6- Methylpyridin- 3-yl)ethyl]-3- (5-methyl-1,3- thiazol-2-yl)-5- (prop-2-yn-1- yloxy) benzamide::US10174016, Example 33::US10202369, Example 33::US10472354, Example 33 P2X purinoceptor 3 Homo sapiens 29.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319866 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319866&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397790 384223146 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632062 C[C@@H](NC(=O)c1cc(OCC#C)cc(c1)-c1ncc(C)s1)c1cnc(C)cn1 InChI=1S/C21H20N4O2S/c1-5-6-27-18-8-16(7-17(9-18)21-24-11-14(3)28-21)20(26)25-15(4)19-12-22-13(2)10-23-19/h1,7-12,15H,6H2,2-4H3,(H,25,26)/t15-/m1/s1 UJLVWKMINNYJSM-OAHLLOKOSA-N 319867 N-[(1R)-1-(5- Methylpyrazin- 2-yl)ethyl]-3- (5-methyl-1,3- thiazol-2-yl)-5- (prop-2-yn-1- yloxy) benzamide::US10174016, Example 34::US10202369, Example 34::US10472354, Example 34 P2X purinoceptor 3 Homo sapiens 111 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319867 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319867&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397514 384223147 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632064 Cc1cnc(s1)-c1cc(OCC#C)cc(c1)C(=O)NCc1cnc(C)cn1 InChI=1S/C20H18N4O2S/c1-4-5-26-18-7-15(6-16(8-18)20-24-10-14(3)27-20)19(25)23-12-17-11-21-13(2)9-22-17/h1,6-11H,5,12H2,2-3H3,(H,23,25) HKQDCIZFKBUDQD-UHFFFAOYSA-N 319868 N-[(5- Methylpyrazin- 2-yl)methyl]- 3-(5-methyl- 1,3-thiazol-2- yl)-5-(prop-2- yn-1- yloxy)benzamide::US10174016, Example 35::US10202369, Example 35::US10472354, Example 35 P2X purinoceptor 3 Homo sapiens 460 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319868 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319868&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397704 384223148 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632066 C[C@@H](NC(=O)c1cc(OCC#C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C21H17F3N4O2S/c1-4-5-30-17-7-14(6-15(8-17)19-25-9-12(2)31-19)18(29)28-13(3)16-10-26-20(27-11-16)21(22,23)24/h1,6-11,13H,5H2,2-3H3,(H,28,29)/t13-/m1/s1 BTRSFHCVZJPJKT-CYBMUJFWSA-N 319869 3-(5-Methyl- 1,3-thiazol-2- yl)-5-(prop-2- yn-1-yloxy)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 36::US10202369, Example 36::US10472354, Example 36 P2X purinoceptor 3 Homo sapiens 14.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319869 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319869&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397309 384223149 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632068 C[C@@H](NC(=O)c1cc(OCC#C)cc(c1)-c1ncc(C)s1)c1ccc(C)nn1 InChI=1S/C21H20N4O2S/c1-5-8-27-18-10-16(9-17(11-18)21-22-12-14(3)28-21)20(26)23-15(4)19-7-6-13(2)24-25-19/h1,6-7,9-12,15H,8H2,2-4H3,(H,23,26)/t15-/m1/s1 IZIUFNSLLIEWJE-OAHLLOKOSA-N 319870 N-[(1R)-1-(6- Methylpyridazin- 3-yl)ethyl]- 3-(5-methyl- 1,3-thiazol-2- yl)-5-(prop-2- yn-1- yloxy) benzamide::US10174016, Example 37::US10202369, Example 37::US10472354, Example 37 P2X purinoceptor 3 Homo sapiens 55.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319870 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319870&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397261 384223150 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625526 C[C@@H](NC(=O)c1cc(OCC2CCOCC2)cc(c1)-c1ncc(s1)C1CCC1)c1cnc(nc1)C(F)(F)F InChI=1S/C27H29F3N4O3S/c1-16(21-12-32-26(33-13-21)27(28,29)30)34-24(35)19-9-20(25-31-14-23(38-25)18-3-2-4-18)11-22(10-19)37-15-17-5-7-36-8-6-17/h9-14,16-18H,2-8,15H2,1H3,(H,34,35)/t16-/m1/s1 XFOWUTGLWQUPCN-MRXNPFEDSA-N 319953 3-(5-Cyclobutyl-1,3-thiazol-2-yl)-5-(tetrahydro-2H-pyran-4-ylmethoxy)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 120::US10202369, Example 120::US10472354, Example 120 P2X purinoceptor 3 Homo sapiens 14.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319953 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319953&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397437 384223233 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625528 C[C@@H](NC(=O)c1cc(OC[C@H]2CCOC2)cc(c1)-c1ncc(s1)C1CCC1)c1cnc(C)cn1 InChI=1S/C26H30N4O3S/c1-16-11-28-23(12-27-16)17(2)30-25(31)20-8-21(26-29-13-24(34-26)19-4-3-5-19)10-22(9-20)33-15-18-6-7-32-14-18/h8-13,17-19H,3-7,14-15H2,1-2H3,(H,30,31)/t17-,18+/m1/s1 ZBRXLMDGZXDHGV-MSOLQXFVSA-N 319954 3-(5-Cyclobutyl-1,3-thiazol-2-yl)-N-[(1R)-1-(5-methylpyrazin-2-yl)ethyl]-5-[(3S)-tetrahydrofuran-3-ylmethoxy]benzamide::US10174016, Example 121::US10202369, Example 121::US10472354, Example 271 P2X purinoceptor 3 Homo sapiens 79.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319954 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319954&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397486 384223234 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625530 Cc1ccc(CNC(=O)c2cc(OC[C@H]3CCOC3)cc(c2)-c2ncc(s2)C2CCC2)nn1 InChI=1S/C25H28N4O3S/c1-16-5-6-21(29-28-16)12-26-24(30)19-9-20(25-27-13-23(33-25)18-3-2-4-18)11-22(10-19)32-15-17-7-8-31-14-17/h5-6,9-11,13,17-18H,2-4,7-8,12,14-15H2,1H3,(H,26,30)/t17-/m0/s1 DCRIJNFHBDAZLX-KRWDZBQOSA-N 319955 3-(5-Cyclobutyl-1,3-thiazol-2-yl)-N-[(6-methylpyridazin-3-yl)methyl]-5-[(3S)-tetrahydrofuran-3-ylmethoxy]benzamide::US10174016, Example 122::US10202369, Example 122::US10472354, Example 122 P2X purinoceptor 3 Homo sapiens 106 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319955 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319955&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397270 384223235 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625532 C[C@@H](NC(=O)c1cc(OC[C@H]2CCOC2)cc(c1)-c1ncc(s1)C1CCC1)c1cnc(nc1)C(F)(F)F InChI=1S/C26H27F3N4O3S/c1-15(20-10-31-25(32-11-20)26(27,28)29)33-23(34)18-7-19(24-30-12-22(37-24)17-3-2-4-17)9-21(8-18)36-14-16-5-6-35-13-16/h7-12,15-17H,2-6,13-14H2,1H3,(H,33,34)/t15-,16+/m1/s1 JWRPHAGJMIAQMD-CVEARBPZSA-N 319956 3-(5-Cyclobutyl-1,3-thiazol-2-yl)-5-[(3S)-tetrahydrofuran-3-ylmethoxy]-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 123::US10202369, Example 123::US10472354, Example 272 P2X purinoceptor 3 Homo sapiens 46.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319956 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319956&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397161 384223236 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625534 C[C@@H](NC(=O)c1cc(OCC2CCOCC2)cc(c1)-c1ncc(s1)C1CCC1)c1cnc(C)nc1 InChI=1S/C27H32N4O3S/c1-17(23-13-28-18(2)29-14-23)31-26(32)21-10-22(27-30-15-25(35-27)20-4-3-5-20)12-24(11-21)34-16-19-6-8-33-9-7-19/h10-15,17,19-20H,3-9,16H2,1-2H3,(H,31,32)/t17-/m1/s1 WEHPOEFAIDTUPC-QGZVFWFLSA-N 319957 3-(5-Cyclobutyl-1,3-thiazol-2-yl)-N-[(1R)-1-(2-methylpyrimidin-5-yl)ethyl]-5-(tetrahydro-2H-pyran-4-ylmethoxy)benzamide::US10174016, Example 124::US10202369, Example 124::US10472354, Example 124 P2X purinoceptor 3 Homo sapiens 27.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319957 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319957&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397614 384223237 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625536 CCc1cnc(s1)-c1cc(OCC2CCOCC2)cc(c1)C(=O)N[C@H](C)c1cnc(C)nc1 InChI=1S/C25H30N4O3S/c1-4-23-14-28-25(33-23)20-9-19(10-22(11-20)32-15-18-5-7-31-8-6-18)24(30)29-16(2)21-12-26-17(3)27-13-21/h9-14,16,18H,4-8,15H2,1-3H3,(H,29,30)/t16-/m1/s1 DTZIYRRTWOGOEN-MRXNPFEDSA-N 319958 3-(5-Ethyl-1,3-thiazol-2-yl)-N-[(1R)-1-(2-methylpyrimidin-5-yl)ethyl]-5-(tetrahydro-2H-pyran-4-ylmethoxy)benzamide::US10174016, Example 125::US10202369, Example 125::US10472354, Example 125 P2X purinoceptor 3 Homo sapiens 3.00 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319958 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319958&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397256 384223238 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625538 CC(C)c1cnc(s1)-c1cc(OCC2CCOCC2)cc(c1)C(=O)N[C@H](C)c1cnc(C)nc1 InChI=1S/C26H32N4O3S/c1-16(2)24-14-29-26(34-24)21-9-20(10-23(11-21)33-15-19-5-7-32-8-6-19)25(31)30-17(3)22-12-27-18(4)28-13-22/h9-14,16-17,19H,5-8,15H2,1-4H3,(H,30,31)/t17-/m1/s1 OFIYJECBOJUELW-QGZVFWFLSA-N 319959 N-[(1R)-1-(2-Methylpyrimidin-5-yl)ethyl]-3-[5-(propan-2-yl)-1,3-thiazol-2-yl]-5-(tetrahydro-2H-pyran-4-ylmethoxy)benzamide::US10174016, Example 126::US10202369, Example 126::US10472354, Example 126 P2X purinoceptor 3 Homo sapiens 34.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319959 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319959&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397136 384223239 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625540 C[C@@H](NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(s1)C1CCC1)c1ccc(C)nn1 InChI=1S/C26H30N4O3S/c1-16-6-7-23(30-29-16)17(2)28-25(31)19-12-20(26-27-15-24(34-26)18-4-3-5-18)14-22(13-19)33-21-8-10-32-11-9-21/h6-7,12-15,17-18,21H,3-5,8-11H2,1-2H3,(H,28,31)/t17-/m1/s1 WWWCBSCSEOPHLV-QGZVFWFLSA-N 319960 3-(5-Cyclobutyl-1,3-thiazol-2-yl)-N-[(1R)-1-(6-methylpyridazin-3-yl)ethyl]-5-(tetrahydro-2H-pyran-4-yloxy)benzamide::US10174016, Example 127::US10202369, Example 127::US10472354, Example 127 P2X purinoceptor 3 Homo sapiens 111 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319960 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319960&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397331 384223240 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625542 CCc1cnc(s1)-c1cc(OC2CCOCC2)cc(c1)C(=O)N[C@H](C)c1ccc(C)nn1 InChI=1S/C24H28N4O3S/c1-4-21-14-25-24(32-21)18-11-17(12-20(13-18)31-19-7-9-30-10-8-19)23(29)26-16(3)22-6-5-15(2)27-28-22/h5-6,11-14,16,19H,4,7-10H2,1-3H3,(H,26,29)/t16-/m1/s1 ZSPSPZOSCRXZOC-MRXNPFEDSA-N 319961 3-(5-Ethyl-1,3-thiazol-2-yl)-N-[(1R)-1-(6-methylpyridazin-3-yl)ethyl]-5-(tetrahydro-2H-pyran-4-yloxy)benzamide::US10174016, Example 128::US10202369, Example 128::US10472354, Example 128 P2X purinoceptor 3 Homo sapiens 10.00 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319961 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319961&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397510 384223241 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625544 CCc1cnc(s1)-c1cc(OC2CCOCC2)cc(c1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C24H25F3N4O3S/c1-3-20-13-28-22(35-20)16-8-15(9-19(10-16)34-18-4-6-33-7-5-18)21(32)31-14(2)17-11-29-23(30-12-17)24(25,26)27/h8-14,18H,3-7H2,1-2H3,(H,31,32)/t14-/m1/s1 HAECKPIYFMDTPM-CQSZACIVSA-N 319962 3-(5-Ethyl-1,3-thiazol-2-yl)-5-(tetrahydro-2H-pyran-4-yloxy)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 129::US10202369, Example 129::US10472354, Example 129 P2X purinoceptor 3 Homo sapiens 3.00 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319962 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319962&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397362 384223242 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625546 C[C@@H](NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1cnc(C)nc1 InChI=1S/C22H24N4O3S/c1-13-9-25-22(30-13)17-6-16(7-20(8-17)29-19-4-5-28-12-19)21(27)26-14(2)18-10-23-15(3)24-11-18/h6-11,14,19H,4-5,12H2,1-3H3,(H,26,27)/t14-,19+/m1/s1 RHVHBKMOULQMJQ-KUHUBIRLSA-N 319963 N-[(1R)-1-(2-Methylpyrimidin-5-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(3S)-tetrahydrofuran-3-yloxy]benzamide::US10174016, Example 130::US10202369, Example 130::US10472354, Example 130 P2X purinoceptor 3 Homo sapiens 74.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319963 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319963&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397599 384223243 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625548 C[C@@H](NC(=O)c1cc(Oc2ccc(C)nc2)cc(c1)-c1ncc(C)s1)c1cnc(C)cn1 InChI=1S/C24H23N5O2S/c1-14-5-6-20(12-25-14)31-21-8-18(7-19(9-21)24-28-11-16(3)32-24)23(30)29-17(4)22-13-26-15(2)10-27-22/h5-13,17H,1-4H3,(H,29,30)/t17-/m1/s1 PZARJLLATJAKMG-QGZVFWFLSA-N 319964 N-[(1R)-1-(5-methylpyrazin-2-yl)ethyl]-3-[(6-methylpyridin-3-yl)oxy]-5-(5-methyl-1,3-thiazol-2-yl)benzamide::US10174016, Example 131::US10202369, Example 131::US10472354, Example 131 P2X purinoceptor 3 Homo sapiens 134 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319964 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319964&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397434 384223244 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625550 CC(NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ncc(F)cc1Cl InChI=1S/C22H21ClFN3O3S/c1-12-9-26-22(31-12)15-5-14(6-18(7-15)30-17-3-4-29-11-17)21(28)27-13(2)20-19(23)8-16(24)10-25-20/h5-10,13,17H,3-4,11H2,1-2H3,(H,27,28)/t13?,17-/m0/s1 YETTUNLUNMEXML-RUINGEJQSA-N 319965 N-[1-(3-Chloro-5-fluoropyridin-2-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(3S)-tetrahydrofuran-3-yloxy]benzamide::US10174016, Example 132::US10202369, Example 132::US10472354, Example 132 P2X purinoceptor 3 Homo sapiens 75.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319965 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319965&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397504 384223245 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625552 Cc1cnc(s1)-c1cc(O[C@H]2CCOC2)cc(c1)C(=O)NCc1ccc(C)nn1 InChI=1S/C21H22N4O3S/c1-13-3-4-17(25-24-13)11-22-20(26)15-7-16(21-23-10-14(2)29-21)9-19(8-15)28-18-5-6-27-12-18/h3-4,7-10,18H,5-6,11-12H2,1-2H3,(H,22,26)/t18-/m0/s1 VKRRMZCTKMLCQJ-SFHVURJKSA-N 319966 N-[(6-Methylpyridazin-3-yl)methyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(3S)-tetrahydrofuran-3-yloxy]benzamide::US10174016, Example 133::US10202369, Example 133::US10472354, Example 133 P2X purinoceptor 3 Homo sapiens 177 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319966 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319966&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397536 384223246 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625554 CC(NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ncc(Cl)cc1F InChI=1S/C22H21ClFN3O3S/c1-12-9-26-22(31-12)15-5-14(6-18(7-15)30-17-3-4-29-11-17)21(28)27-13(2)20-19(24)8-16(23)10-25-20/h5-10,13,17H,3-4,11H2,1-2H3,(H,27,28)/t13?,17-/m0/s1 DLODQDUFIVUCLQ-RUINGEJQSA-N 319967 N-[1-(5-Chloro-3-fluoropyridin-2-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(3S)-tetrahydrofuran-3-yloxy]benzamide::US10174016, Example 134::US10202369, Example 134::US10472354, Example 134 P2X purinoceptor 3 Homo sapiens 15.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319967 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319967&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397151 384223247 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625556 C[C@@H](NC(=O)c1cc(OC[C@H]2CCOC2)cc(c1)-c1ncc(s1)C1CCC1)c1ccc(C)nn1 InChI=1S/C26H30N4O3S/c1-16-6-7-23(30-29-16)17(2)28-25(31)20-10-21(26-27-13-24(34-26)19-4-3-5-19)12-22(11-20)33-15-18-8-9-32-14-18/h6-7,10-13,17-19H,3-5,8-9,14-15H2,1-2H3,(H,28,31)/t17-,18+/m1/s1 KRMAXJMLJAVOGJ-MSOLQXFVSA-N 319968 3-(5-Cyclobutyl-1,3-thiazol-2-yl)-N-[(1R)-1-(6-methylpyridazin-3-yl)ethyl]-5-[(3S)-tetrahydrofuran-3-ylmethoxy]benzamide::US10174016, Example 135::US10202369, Example 135::US10472354, Example 270 P2X purinoceptor 3 Homo sapiens 35.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319968 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319968&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397422 384223248 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625558 COCCOc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1cnc(C)nc1 InChI=1S/C21H24N4O3S/c1-13-10-24-21(29-13)17-7-16(8-19(9-17)28-6-5-27-4)20(26)25-14(2)18-11-22-15(3)23-12-18/h7-12,14H,5-6H2,1-4H3,(H,25,26)/t14-/m1/s1 NMXUVEDIBFBQMK-CQSZACIVSA-N 319969 3-(2-Methoxyethoxy)-N-[(1R)-1-(2-methylpyrimidin-5-yl)ethyl]-5-(5-methyl-1,3-thiazol-2-yl)benzamide::US10174016, Example 136::US10202369, Example 136::US10472354, Example 136 P2X purinoceptor 3 Homo sapiens 196 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319969 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319969&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397574 384223249 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625560 C[C@@H](NC(=O)c1cc(OC2CCN(CC2)C(=O)OC(C)(C)C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C28H32F3N5O4S/c1-16-13-32-24(41-16)19-10-18(23(37)35-17(2)20-14-33-25(34-15-20)28(29,30)31)11-22(12-19)39-21-6-8-36(9-7-21)26(38)40-27(3,4)5/h10-15,17,21H,6-9H2,1-5H3,(H,35,37)/t17-/m1/s1 FLJTWWMLFZUWSL-QGZVFWFLSA-N 319970 US10174016, Example 137::US10472354, Example 137::tert-Butyl 4-[3-(5-methyl-1,3-thiazol-2-yl)-5-({(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}carbamoyl)phenoxy]piperidine-1-carboxylate P2X purinoceptor 3 Homo sapiens 26.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319970 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319970&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397466 384223250 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625562 C[C@@H](NC(=O)c1cc(OC2CCNCC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H24F3N5O2S/c1-13-10-28-21(34-13)16-7-15(8-19(9-16)33-18-3-5-27-6-4-18)20(32)31-14(2)17-11-29-22(30-12-17)23(24,25)26/h7-12,14,18,27H,3-6H2,1-2H3,(H,31,32)/t14-/m1/s1 AUEVADIQWKJNQT-CQSZACIVSA-N 319971 3-(5-Methyl-1,3-thiazol-2-yl)-5-(piperidin-4-yloxy)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 138::US10202369, Example 138::US10472354, Example 138 P2X purinoceptor 3 Homo sapiens 11.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319971 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319971&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397389 384223251 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625564 C[C@@H](NC(=O)c1cc(OC2CCN(C)CC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H26F3N5O2S/c1-14-11-28-22(35-14)17-8-16(9-20(10-17)34-19-4-6-32(3)7-5-19)21(33)31-15(2)18-12-29-23(30-13-18)24(25,26)27/h8-13,15,19H,4-7H2,1-3H3,(H,31,33)/t15-/m1/s1 BKNIRTNEYAOJDL-OAHLLOKOSA-N 319972 3-[(1-Methylpiperidin-4-yl)oxy]-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 139::US10202369, Example 139::US10472354, Example 215 P2X purinoceptor 3 Homo sapiens 8.00 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319972 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319972&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397521 384223252 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625566 CC(C)N1CCC(CC1)Oc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C26H30F3N5O2S/c1-15(2)34-7-5-21(6-8-34)36-22-10-18(9-19(11-22)24-30-12-16(3)37-24)23(35)33-17(4)20-13-31-25(32-14-20)26(27,28)29/h9-15,17,21H,5-8H2,1-4H3,(H,33,35)/t17-/m1/s1 JAJQPYKLEVBCIY-QGZVFWFLSA-N 319973 3-(5-Methyl-1,3-thiazol-2-yl)-5-{[1-(propan-2-yl)piperidin-4-yl]oxy}-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 140::US10202369, Example 140::US10472354, Example 140 P2X purinoceptor 3 Homo sapiens 33.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319973 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319973&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397336 384223253 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625568 C[C@@H](NC(=O)c1cc(O[C@@H]2CCN(C)C2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H24F3N5O2S/c1-13-9-27-21(34-13)16-6-15(7-19(8-16)33-18-4-5-31(3)12-18)20(32)30-14(2)17-10-28-22(29-11-17)23(24,25)26/h6-11,14,18H,4-5,12H2,1-3H3,(H,30,32)/t14-,18-/m1/s1 RNHSPVKPEXJLAD-RDTXWAMCSA-N 319974 3-{[(3R)-1-Methylpyrrolidin-3-yl]oxy}-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 141::US10202369, Example 141::US10472354, Example 141 P2X purinoceptor 3 Homo sapiens 43.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319974 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319974&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397272 384223254 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625570 C[C@@H](NC(=O)c1cc(O[C@H]2CCN(C)C2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H24F3N5O2S/c1-13-9-27-21(34-13)16-6-15(7-19(8-16)33-18-4-5-31(3)12-18)20(32)30-14(2)17-10-28-22(29-11-17)23(24,25)26/h6-11,14,18H,4-5,12H2,1-3H3,(H,30,32)/t14-,18+/m1/s1 RNHSPVKPEXJLAD-KDOFPFPSSA-N 319975 3-{[(3S)-1-Methylpyrrolidin-3-yl]oxy}-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 142::US10202369, Example 142::US10472354, Example 142 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319975 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319975&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397181 384223255 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625572 C[C@@H](NC(=O)c1cc(OC2CN(C)C2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C22H22F3N5O2S/c1-12-7-26-20(33-12)15-4-14(5-17(6-15)32-18-10-30(3)11-18)19(31)29-13(2)16-8-27-21(28-9-16)22(23,24)25/h4-9,13,18H,10-11H2,1-3H3,(H,29,31)/t13-/m1/s1 NFRXFSQBXDHWHW-CYBMUJFWSA-N 319976 3-[(1-Methylazetidin-3-yl)oxy]-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 143::US10202369, Example 143::US10472354, Example 143 P2X purinoceptor 3 Homo sapiens 84.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319976 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319976&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397519 384223256 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625574 C[C@H](NC(=O)c1cc(OCC#C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C21H17F3N4O2S/c1-4-5-30-17-7-14(6-15(8-17)19-25-9-12(2)31-19)18(29)28-13(3)16-10-26-20(27-11-16)21(22,23)24/h1,6-11,13H,5H2,2-3H3,(H,28,29)/t13-/m0/s1 BTRSFHCVZJPJKT-ZDUSSCGKSA-N 319977 3-(5-Methyl-1,3-thiazol-2-yl)-5-(prop-2-yn-1-yloxy)-N-{(1S)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 144::US10202369, Example 144::US10472354, Example 144 P2X purinoceptor 3 Homo sapiens 825 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319977 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319977&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397460 384223257 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625576 C[C@H](NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H23F3N4O3S/c1-13-10-27-21(34-13)16-7-15(8-19(9-16)33-18-3-5-32-6-4-18)20(31)30-14(2)17-11-28-22(29-12-17)23(24,25)26/h7-12,14,18H,3-6H2,1-2H3,(H,30,31)/t14-/m0/s1 WGQQHPGXKFPPTQ-AWEZNQCLSA-N 319978 3-(5-Methyl-1,3-thiazol-2-yl)-5-(tetrahydro-2H-pyran-4-yloxy)-N-{(1S)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 145::US10202369, Example 145::US10472354, Example 145 P2X purinoceptor 3 Homo sapiens 271 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319978 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319978&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397306 384223258 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625578 C[C@@H](NC(=O)c1cc(OC2CC3(C2)CN(C3)C(=O)OC(C)(C)C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C29H32F3N5O4S/c1-16-11-33-24(42-16)19-6-18(23(38)36-17(2)20-12-34-25(35-13-20)29(30,31)32)7-21(8-19)40-22-9-28(10-22)14-37(15-28)26(39)41-27(3,4)5/h6-8,11-13,17,22H,9-10,14-15H2,1-5H3,(H,36,38)/t17-/m1/s1 GOFUMWOIVIXXIJ-QGZVFWFLSA-N 319979 US10174016, Example 146::US10202369, Example 146::US10472354, Example 146::tert-butyl 6-[3-(5- methyl-1,3- thiazol-2-yl)-5- ({(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}carbamoyl) phenoxy]-2- azaspiro[3.3]heptane- 2-carboxylate P2X purinoceptor 3 Homo sapiens 45.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319979 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319979&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397340 384223259 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625580 C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1cnc(cn1)C(F)(F)F InChI=1S/C22H21F3N4O3S/c1-12-8-28-21(33-12)15-5-14(6-17(7-15)32-16-3-4-31-11-16)20(30)29-13(2)18-9-27-19(10-26-18)22(23,24)25/h5-10,13,16H,3-4,11H2,1-2H3,(H,29,30)/t13-,16-/m1/s1 DVMONFUPUPPMFW-CZUORRHYSA-N 319980 3-(5-methyl-1,3- thiazol-2-yl)-5- [(3R)- tetrahydrofuran-3- yloxy]-N-{(1R)-1- [5- (trifluoromethyl) pyrazin-2- yl]ethyl}benzamide::US10174016, Example 147::US10202369, Example 147::US10472354, Example 147 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319980 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319980&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397189 384223260 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625582 C[C@@H](NC(=O)c1cc(OC2COC2)cc(c1)-c1ncc(C)s1)c1ccc(nc1)C(F)(F)F InChI=1S/C22H20F3N3O3S/c1-12-8-27-21(32-12)16-5-15(6-17(7-16)31-18-10-30-11-18)20(29)28-13(2)14-3-4-19(26-9-14)22(23,24)25/h3-9,13,18H,10-11H2,1-2H3,(H,28,29)/t13-/m1/s1 NAXHTXVAPBZYNR-CYBMUJFWSA-N 319981 3-(5-methyl-1,3- thiazol-2-yl)-5- (oxetan-3-yloxy)- N-{(1R)-1-[6- (trifluoromethyl) pyridin-3- yl]ethyl}benzamide::US10174016, Example 148::US10202369, Example 148::US10472354, Example 148 P2X purinoceptor 3 Homo sapiens 33.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319981 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319981&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397138 384223261 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625584 C[C@@H](NC(=O)c1cc(OC23CCN(CC2)CC3)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C25H26F3N5O2S/c1-15-12-29-22(36-15)18-9-17(10-20(11-18)35-24-3-6-33(7-4-24)8-5-24)21(34)32-16(2)19-13-30-23(31-14-19)25(26,27)28/h9-14,16H,3-8H2,1-2H3,(H,32,34)/t16-/m1/s1 RAGSAJSSGMANHP-MRXNPFEDSA-N 319982 3-(1- azabicyclo[2.2.2] oct-4-yloxy)-5-(5- methyl-1,3- thiazol-3-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 149::US10202369, Example 149::US10472354, Example 149 P2X purinoceptor 3 Homo sapiens 21.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319982 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319982&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397715 384223262 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625586 C[C@@H](NC(=O)c1cc(OC2CCN(CC2)C(C)=O)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C25H26F3N5O3S/c1-14-11-29-23(37-14)18-8-17(9-21(10-18)36-20-4-6-33(7-5-20)16(3)34)22(35)32-15(2)19-12-30-24(31-13-19)25(26,27)28/h8-13,15,20H,4-7H2,1-3H3,(H,32,35)/t15-/m1/s1 ISMQQTCWBNBFKY-OAHLLOKOSA-N 319983 3-[(1- acetylpiperidin-4- yl)oxy]-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 150::US10202369, Example 150::US10472354, Example 150 P2X purinoceptor 3 Homo sapiens 12.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319983 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319983&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397215 384223263 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632070 C[C@@H](NC(=O)c1cc(OCC#C)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F InChI=1S/C21H17F3N4O2S/c1-4-7-30-16-9-14(8-15(10-16)20-25-11-12(2)31-20)19(29)26-13(3)17-5-6-18(28-27-17)21(22,23)24/h1,5-6,8-11,13H,7H2,2-3H3,(H,26,29)/t13-/m1/s1 PNZFOFJAUOCDQW-CYBMUJFWSA-N 319871 3-(5-Methyl- 1,3-thiazol-2- yl)-5-(prop-2- yn-1-yloxy)-N- [(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl] benzamide::US10174016, Example 38::US10202369, Example 38::US10472354, Example 38 P2X purinoceptor 3 Homo sapiens 55.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319871 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319871&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397333 384223151 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632072 C[C@@H](NC(=O)c1cc(OCC#C)cc(c1)-c1ncc(C)s1)c1cnc(C)nc1 InChI=1S/C21H20N4O2S/c1-5-6-27-19-8-16(7-17(9-19)21-24-10-13(2)28-21)20(26)25-14(3)18-11-22-15(4)23-12-18/h1,7-12,14H,6H2,2-4H3,(H,25,26)/t14-/m1/s1 OVENJFXCZONLOP-CQSZACIVSA-N 319872 N-[(1R)-1-(2- Methylpyrimidin- 5-yl)ethyl]- 3-(5-methyl- 1,3-thiazol-2- yl)-5-(prop-2- yn-1- yloxy) benzamide::US10174016, Example 39::US10202369, Example 39::US10472354, Example 39 P2X purinoceptor 3 Homo sapiens 81.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319872 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319872&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397588 384223152 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632074 CC#CCOc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C22H19F3N4O2S/c1-4-5-6-31-18-8-15(7-16(9-18)20-26-10-13(2)32-20)19(30)29-14(3)17-11-27-21(28-12-17)22(23,24)25/h7-12,14H,6H2,1-3H3,(H,29,30)/t14-/m1/s1 XSZOYFWYESZINQ-CQSZACIVSA-N 319873 3-(But-2-yn-1- yloxy)-5-(5- methyl-1,3- thiazol-2-yl)- N-[(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl] benzamide::US10174016, Example 40::US10202369, Example 40::US10472354, Example 40 P2X purinoceptor 3 Homo sapiens 16.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319873 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319873&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397357 384223153 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632076 CC#CCOc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1nnc(C)s1 InChI=1S/C20H20N4O2S2/c1-5-6-7-26-17-9-15(8-16(10-17)20-21-11-12(2)27-20)18(25)22-13(3)19-24-23-14(4)28-19/h8-11,13H,7H2,1-4H3,(H,22,25)/t13-/m1/s1 ORWZAOZYNYEGDS-CYBMUJFWSA-N 319874 3-(But-2-yn-1- yloxy)-N-[(1R)- 1-(5-methyl- 1,3,4- thiadiazol-2- yl)ethyl]-5-(5- methyl-1,3- thiazol-2- yl)benzamide::US10174016, Example 41::US10202369, Example 41::US10472354, Example 41 P2X purinoceptor 3 Homo sapiens 130 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319874 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319874&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397286 384223154 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632078 C[C@@H](NC(=O)c1cc(OC2COC2)cc(c1)-c1ncc(C)s1)c1cnc(C)cn1 InChI=1S/C21H22N4O3S/c1-12-7-23-19(9-22-12)14(3)25-20(26)15-4-16(21-24-8-13(2)29-21)6-17(5-15)28-18-10-27-11-18/h4-9,14,18H,10-11H2,1-3H3,(H,25,26)/t14-/m1/s1 AWWAAAATSKEOQH-CQSZACIVSA-N 319875 N-[(1R)-1-(5-Methylpyrazin-2-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-(oxetan-3-yloxy)benzamide::US10174016, Example 42::US10202369, Example 42::US10472354, Example 42 P2X purinoceptor 3 Homo sapiens 129 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319875 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319875&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397394 384223155 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632080 C[C@@H](NC(=O)c1cc(OC2COC2)cc(c1)-c1ncc(C)s1)c1cnc(C)nc1 InChI=1S/C21H22N4O3S/c1-12-7-24-21(29-12)16-4-15(5-18(6-16)28-19-10-27-11-19)20(26)25-13(2)17-8-22-14(3)23-9-17/h4-9,13,19H,10-11H2,1-3H3,(H,25,26)/t13-/m1/s1 QZYMXYIOESSIBG-CYBMUJFWSA-N 319876 N-[(1R)-1-(2-Methylpyrimidin-5-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-(oxetan-3-yloxy)benzamide::US10174016, Example 43::US10202369, Example 43::US10472354, Example 43 P2X purinoceptor 3 Homo sapiens 50.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319876 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319876&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397750 384223156 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632082 CC(NC(=O)c1cc(OC2COC2)cc(c1)-c1ncc(C)s1)c1ncc(Cl)cc1F InChI=1S/C21H19ClFN3O3S/c1-11-7-25-21(30-11)14-3-13(4-16(5-14)29-17-9-28-10-17)20(27)26-12(2)19-18(23)6-15(22)8-24-19/h3-8,12,17H,9-10H2,1-2H3,(H,26,27) DXVSMJSLGFWBSV-UHFFFAOYSA-N 319877 N-[1-(5-Chloro-3-fluoropyridin-2-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-(oxetan-3-yloxy)benzamide::US10174016, Example 44::US10202369, Example 44::US10472354, Example 44 P2X purinoceptor 3 Homo sapiens 11.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319877 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319877&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397182 384223157 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632084 Cc1cnc(s1)-c1cc(OC2COC2)cc(c1)C(=O)NCc1ccc(C)nn1 InChI=1S/C20H20N4O3S/c1-12-3-4-16(24-23-12)9-21-19(25)14-5-15(20-22-8-13(2)28-20)7-17(6-14)27-18-10-26-11-18/h3-8,18H,9-11H2,1-2H3,(H,21,25) AFIPEIBYSBBLBJ-UHFFFAOYSA-N 319878 N-[(6-Methylpyridazin-3-yl)methyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-(oxetan-3-yloxy)benzamide::US10174016, Example 45::US10202369, Example 45::US10472354, Example 45 P2X purinoceptor 3 Homo sapiens 212 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319878 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319878&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397740 384223158 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632086 C[C@@H](NC(=O)c1cc(OC2COC2)cc(c1)-c1ncc(C)s1)c1ccc(Cl)cn1 InChI=1S/C21H20ClN3O3S/c1-12-8-24-21(29-12)15-5-14(6-17(7-15)28-18-10-27-11-18)20(26)25-13(2)19-4-3-16(22)9-23-19/h3-9,13,18H,10-11H2,1-2H3,(H,25,26)/t13-/m1/s1 FFCGGIUVAQWIMW-CYBMUJFWSA-N 319879 N-[(1R)-1-(5-Chloropyridin-2-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-(oxetan-3-yloxy)benzamide::US10174016, Example 46::US10202369, Example 46::US10472354, Example 46 P2X purinoceptor 3 Homo sapiens 10.00 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319879 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319879&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397660 384223159 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632088 C[C@@H](NC(=O)c1cc(OC2COC2)cc(c1)-c1ncc(C)s1)c1ccc(C)nn1 InChI=1S/C21H22N4O3S/c1-12-4-5-19(25-24-12)14(3)23-20(26)15-6-16(21-22-9-13(2)29-21)8-17(7-15)28-18-10-27-11-18/h4-9,14,18H,10-11H2,1-3H3,(H,23,26)/t14-/m1/s1 HFDOVXXFUCEVBK-CQSZACIVSA-N 319880 N-[(1R)-1-(6-Methylpyridazin-3-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-(oxetan-3-yloxy)benzamide::US10174016, Example 47::US10202369, Example 47::US10472354, Example 47 P2X purinoceptor 3 Homo sapiens 82.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319880&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397352 384223160 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632090 C[C@@H](NC(=O)c1cc(OC2COC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C21H19F3N4O3S/c1-11-6-25-19(32-11)14-3-13(4-16(5-14)31-17-9-30-10-17)18(29)28-12(2)15-7-26-20(27-8-15)21(22,23)24/h3-8,12,17H,9-10H2,1-2H3,(H,28,29)/t12-/m1/s1 HXNSKECKPLVRIH-GFCCVEGCSA-N 319881 3-(5-Methyl-1,3-thiazol-2-yl)-5-(oxetan-3-yloxy)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 48::US10202369, Example 48::US10472354, Example 48 P2X purinoceptor 3 Homo sapiens 14.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319881 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319881&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397291 384223161 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632092 CC(NC(=O)c1cc(OC2COC2)cc(c1)-c1ncc(C)s1)c1ncc(F)cc1Cl InChI=1S/C21H19ClFN3O3S/c1-11-7-25-21(30-11)14-3-13(4-16(5-14)29-17-9-28-10-17)20(27)26-12(2)19-18(22)6-15(23)8-24-19/h3-8,12,17H,9-10H2,1-2H3,(H,26,27) FNMVOFQACWEVTO-UHFFFAOYSA-N 319882 N-[1-(3-Chloro-5-fluoropyridin-2-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-(oxetan-3-yloxy)benzamide::US10174016, Example 49::US10202369, Example 49::US10472354, Example 49 P2X purinoceptor 3 Homo sapiens 132 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319882 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319882&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397320 384223162 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632094 C[C@@H](NC(=O)c1cc(OC2COC2)cc(c1)-c1ncc(C)s1)c1nnc(C)s1 InChI=1S/C19H20N4O3S2/c1-10-7-20-19(27-10)14-4-13(5-15(6-14)26-16-8-25-9-16)17(24)21-11(2)18-23-22-12(3)28-18/h4-7,11,16H,8-9H2,1-3H3,(H,21,24)/t11-/m1/s1 RQBQZBLVECLWLL-LLVKDONJSA-N 319883 N-[(1R)-1-(5-Methyl-1,3,4-thiadiazol-2-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-(oxetan-3-yloxy)benzamide::US10174016, Example 50::US10202369, Example 50 P2X purinoceptor 3 Homo sapiens 77.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319883 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319883&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397179 384223163 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632096 C[C@@H](NC(=O)c1cc(OC2COC2)cc(c1)-c1ncc(C)s1)c1ccc(C)nc1 InChI=1S/C22H23N3O3S/c1-13-4-5-16(10-23-13)15(3)25-21(26)17-6-18(22-24-9-14(2)29-22)8-19(7-17)28-20-11-27-12-20/h4-10,15,20H,11-12H2,1-3H3,(H,25,26)/t15-/m1/s1 MHQNYPHPPSGTBD-OAHLLOKOSA-N 319884 N-[(1R)-1-(6-methylpyridin-3-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-(oxetan-3-yloxy)benzamide::US10174016, Example 51::US10202369, Example 51 P2X purinoceptor 3 Homo sapiens 74.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319884 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319884&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397804 384223164 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632098 Cc1cnc(s1)-c1cc(OC2COC2)cc(c1)C(=O)NCc1ccc(nn1)C(F)(F)F InChI=1S/C20H17F3N4O3S/c1-11-7-25-19(31-11)13-4-12(5-15(6-13)30-16-9-29-10-16)18(28)24-8-14-2-3-17(27-26-14)20(21,22)23/h2-7,16H,8-10H2,1H3,(H,24,28) KTKYNBLLOZOZPY-UHFFFAOYSA-N 319885 3-(5-Methyl- 1,3-thiazol-2- yl)-5-(oxetan- 3-yloxy)-N-{[6- (trifluoromethyl) pyridazin-3- yl]methyl} benzamide::US10174016, Example 52::US10202369, Example 52::US10472354, Example 52 P2X purinoceptor 3 Homo sapiens 194 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319885 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319885&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397650 384223165 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632100 CC[C@@H](NC(=O)c1cc(OC2COC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C22H21F3N4O3S/c1-3-18(15-8-27-21(28-9-15)22(23,24)25)29-19(30)13-4-14(20-26-7-12(2)33-20)6-16(5-13)32-17-10-31-11-17/h4-9,17-18H,3,10-11H2,1-2H3,(H,29,30)/t18-/m1/s1 PHCWFMJDVHAVQT-GOSISDBHSA-N 319886 3-(5-Methyl- 1,3-thiazol-2- yl)-5-(oxetan- 3-yloxy)-N- [(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]propyl] benzamide::US10174016, Example 53::US10202369, Example 53::US10472354, Example 53 P2X purinoceptor 3 Homo sapiens 318 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319886 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319886&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397526 384223166 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632102 Cc1cnc(s1)-c1cc(OC[C@@H]2CCCO2)cc(c1)C(=O)NCc1ccc(C)nn1 InChI=1S/C22H24N4O3S/c1-14-5-6-18(26-25-14)12-23-21(27)16-8-17(22-24-11-15(2)30-22)10-20(9-16)29-13-19-4-3-7-28-19/h5-6,8-11,19H,3-4,7,12-13H2,1-2H3,(H,23,27)/t19-/m0/s1 IFCRFQDQDLUKDL-IBGZPJMESA-N 319887 N-[(6-Methylpyridazin-3-yl)methyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(2S)-tetrahydrofuran-2-ylmethoxy]benzamide::US10174016, Example 54::US10202369, Example 54::US10472354, Example 54 P2X purinoceptor 3 Homo sapiens 66.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319887 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319887&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397485 384223167 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632104 Cc1cnc(s1)-c1cc(OC[C@@H]2CCCO2)cc(c1)C(=O)NCc1ncc(Cl)cc1F InChI=1S/C22H21ClFN3O3S/c1-13-9-27-22(31-13)15-5-14(6-18(7-15)30-12-17-3-2-4-29-17)21(28)26-11-20-19(24)8-16(23)10-25-20/h5-10,17H,2-4,11-12H2,1H3,(H,26,28)/t17-/m0/s1 UTQWAUZOCBGCBP-KRWDZBQOSA-N 322243 US10183937, Example 55::US10202369, Example 55 P2X purinoceptor 3 Homo sapiens 8.00 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322243 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322243&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397391 384225320 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632106 Cc1cnc(s1)-c1cc(OC[C@@H]2CCCO2)cc(c1)C(=O)NCc1cnc(C)cn1 InChI=1S/C22H24N4O3S/c1-14-9-24-18(11-23-14)12-25-21(27)16-6-17(22-26-10-15(2)30-22)8-20(7-16)29-13-19-4-3-5-28-19/h6-11,19H,3-5,12-13H2,1-2H3,(H,25,27)/t19-/m0/s1 UMCJOKLDVAQWOA-IBGZPJMESA-N 319889 N-[(5-Methylpyrazin-2-yl)methyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(2S)-tetrahydrofuran-2-ylmethoxy]benzamide::US10174016, Example 56::US10202369, Example 56 P2X purinoceptor 3 Homo sapiens 148 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319889 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319889&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397398 384223169 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632108 C[C@@H](NC(=O)c1cc(OC[C@@H]2CCCO2)cc(c1)-c1ncc(C)s1)c1cnc(C)cn1 InChI=1S/C23H26N4O3S/c1-14-10-25-21(12-24-14)16(3)27-22(28)17-7-18(23-26-11-15(2)31-23)9-20(8-17)30-13-19-5-4-6-29-19/h7-12,16,19H,4-6,13H2,1-3H3,(H,27,28)/t16-,19+/m1/s1 MANPQCKCYFRFOG-APWZRJJASA-N 319890 N-[(1R)-1-(5-Methylpyrazin-2-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(2S)-tetrahydrofuran-2-ylmethoxy]benzamide::US10174016, Example 57::US10202369, Example 57::US10472354, Example 57 P2X purinoceptor 3 Homo sapiens 25.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319890 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319890&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397390 384223170 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632110 C[C@@H](NC(=O)c1cc(OC[C@@H]2CCCO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H23F3N4O3S/c1-13-9-27-21(34-13)16-6-15(7-19(8-16)33-12-18-4-3-5-32-18)20(31)30-14(2)17-10-28-22(29-11-17)23(24,25)26/h6-11,14,18H,3-5,12H2,1-2H3,(H,30,31)/t14-,18+/m1/s1 MXZPUDRHAAYJOR-KDOFPFPSSA-N 319891 3-(5-Methyl-1,3-thiazol-2-yl)-5-[(2S)-tetrahydrofuran-2-ylmethoxy]-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 58::US10202369, Example 58::US10472354, Example 58 P2X purinoceptor 3 Homo sapiens 4.00 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319891 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319891&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397134 384223171 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632112 C[C@@H](NC(=O)c1cc(OC[C@@H]2CCCO2)cc(c1)-c1ncc(C)s1)c1ccc(C)nn1 InChI=1S/C23H26N4O3S/c1-14-6-7-21(27-26-14)16(3)25-22(28)17-9-18(23-24-12-15(2)31-23)11-20(10-17)30-13-19-5-4-8-29-19/h6-7,9-12,16,19H,4-5,8,13H2,1-3H3,(H,25,28)/t16-,19+/m1/s1 JHPJVAOLQKHAFN-APWZRJJASA-N 319892 N-[(1R)-1-(6-Methylpyridazin-3-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(2S)-tetrahydrofuran-2-ylmethoxy]benzamide::US10174016, Example 59::US10202369, Example 59::US10472354, Example 59 P2X purinoceptor 3 Homo sapiens 13.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319892 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319892&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397721 384223172 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632114 C[C@@H](NC(=O)c1cc(OC[C@@H]2CCCO2)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F InChI=1S/C23H23F3N4O3S/c1-13-11-27-22(34-13)16-8-15(9-18(10-16)33-12-17-4-3-7-32-17)21(31)28-14(2)19-5-6-20(30-29-19)23(24,25)26/h5-6,8-11,14,17H,3-4,7,12H2,1-2H3,(H,28,31)/t14-,17+/m1/s1 KNJYTDFISMIFTK-PBHICJAKSA-N 319893 3-(5-Methyl-1,3-thiazol-2-yl)-5-[(2S)-tetrahydrofuran-2-ylmethoxy]-N-{(1R)-1-[6-(trifluoromethyl)pyridazin-3-yl]ethyl}benzamide::US10174016, Example 60::US10202369, Example 60::US10472354, Example 60 P2X purinoceptor 3 Homo sapiens 11.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319893 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319893&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397124 384223173 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632116 C[C@@H](NC(=O)c1cc(OC[C@H]2CCCO2)cc(c1)-c1ncc(C)s1)c1ccc(C)nn1 InChI=1S/C23H26N4O3S/c1-14-6-7-21(27-26-14)16(3)25-22(28)17-9-18(23-24-12-15(2)31-23)11-20(10-17)30-13-19-5-4-8-29-19/h6-7,9-12,16,19H,4-5,8,13H2,1-3H3,(H,25,28)/t16-,19-/m1/s1 JHPJVAOLQKHAFN-VQIMIIECSA-N 319894 N-[(1R)-1-(6-methylpyridazin-3-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(2R)-tetrahydrofuran-2-ylmethoxy]benzamide::US10174016, Example 61::US10202369, Example 61::US10472354, Example 61 P2X purinoceptor 3 Homo sapiens 14.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319894 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319894&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397475 384223174 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632118 Cc1cnc(s1)-c1cc(OC[C@H]2CCCO2)cc(c1)C(=O)NCc1ccc(C)nn1 InChI=1S/C22H24N4O3S/c1-14-5-6-18(26-25-14)12-23-21(27)16-8-17(22-24-11-15(2)30-22)10-20(9-16)29-13-19-4-3-7-28-19/h5-6,8-11,19H,3-4,7,12-13H2,1-2H3,(H,23,27)/t19-/m1/s1 IFCRFQDQDLUKDL-LJQANCHMSA-N 319895 N-[(6-Methylpyridazin-3-yl)methyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(2R)-tetrahydrofuran-2-ylmethoxy]benzamide::US10174016, Example 62::US10202369, Example 62::US10472354, Example 62 P2X purinoceptor 3 Homo sapiens 85.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319895 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319895&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397725 384223175 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632120 C[C@@H](NC(=O)c1cc(OC[C@H]2CCCO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H23F3N4O3S/c1-13-9-27-21(34-13)16-6-15(7-19(8-16)33-12-18-4-3-5-32-18)20(31)30-14(2)17-10-28-22(29-11-17)23(24,25)26/h6-11,14,18H,3-5,12H2,1-2H3,(H,30,31)/t14-,18-/m1/s1 MXZPUDRHAAYJOR-RDTXWAMCSA-N 319896 3-(5-Methyl-1,3-thiazol-2-yl)-5-[(2R)-tetrahydrofuran-2-ylmethoxy]-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 63::US10202369, Example 63::US10472354, Example 63 P2X purinoceptor 3 Homo sapiens 4.00 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319896 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319896&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397292 384223176 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632122 C[C@@H](NC(=O)c1cc(OC[C@H]2CCCO2)cc(c1)-c1ncc(C)s1)c1cnc(C)cn1 InChI=1S/C23H26N4O3S/c1-14-10-25-21(12-24-14)16(3)27-22(28)17-7-18(23-26-11-15(2)31-23)9-20(8-17)30-13-19-5-4-6-29-19/h7-12,16,19H,4-6,13H2,1-3H3,(H,27,28)/t16-,19-/m1/s1 MANPQCKCYFRFOG-VQIMIIECSA-N 319897 N-[(1R)-1-(5-methylpyrazin-2-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(2R)-tetrahydrofuran-2-ylmethoxy]benzamide::US10174016, Example 64::US10202369, Example 64::US10472354, Example 64 P2X purinoceptor 3 Homo sapiens 53.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319897 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319897&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397244 384223177 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632124 CC(NC(=O)c1cc(OC[C@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ncc(Cl)cc1F InChI=1S/C23H23ClFN3O3S/c1-13-9-27-23(32-13)17-5-16(6-19(7-17)31-12-15-3-4-30-11-15)22(29)28-14(2)21-20(25)8-18(24)10-26-21/h5-10,14-15H,3-4,11-12H2,1-2H3,(H,28,29)/t14?,15-/m0/s1 NHGFOVVSFOISFI-LOACHALJSA-N 319898 N-[1-(5- Chloro-3- fluoropyridin- 2-yl)ethyl]-3- (5-methyL- 1,3-thiazol-2- yl)-5-[(3S)- tetrahydrofuran- 3-ylmethoxy] benzamide::US10174016, Example 65::US10202369, Example 65::US10472354, Example 65 P2X purinoceptor 3 Homo sapiens 3.00 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319898 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319898&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397187 384223178 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632126 Cc1cnc(s1)-c1cc(OC[C@H]2CCOC2)cc(c1)C(=O)NCc1ccc(C)nn1 InChI=1S/C22H24N4O3S/c1-14-3-4-19(26-25-14)11-23-21(27)17-7-18(22-24-10-15(2)30-22)9-20(8-17)29-13-16-5-6-28-12-16/h3-4,7-10,16H,5-6,11-13H2,1-2H3,(H,23,27)/t16-/m0/s1 SKNHRCMFBDROGE-INIZCTEOSA-N 319899 N-[(6- Methylpyridazin- 3-yl)methyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5-[(3S)- tetrahydrofuran- 3-ylmethoxy] benzamide::US10174016, Example 66::US10202369, Example 66::US10472354, Example 66 P2X purinoceptor 3 Homo sapiens 35.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319899 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319899&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397153 384223179 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632128 Cc1cnc(s1)-c1cc(OC[C@H]2CCOC2)cc(c1)C(=O)NCc1cnc(C)cn1 InChI=1S/C22H24N4O3S/c1-14-8-24-19(10-23-14)11-25-21(27)17-5-18(22-26-9-15(2)30-22)7-20(6-17)29-13-16-3-4-28-12-16/h5-10,16H,3-4,11-13H2,1-2H3,(H,25,27)/t16-/m0/s1 MFTNZVDLSIJVDH-INIZCTEOSA-N 319900 N-[(5- Methylpyrazin- 2-yl)methyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5-[(3S)- tetrahydrofuran- 3-ylmethoxy] benzamide::US10174016, Example 67::US10202369, Example 67::US10472354, Example 67 P2X purinoceptor 3 Homo sapiens 186 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319900 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319900&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397127 384223180 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632130 C[C@@H](NC(=O)c1cc(OC[C@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1cnc(C)cn1 InChI=1S/C23H26N4O3S/c1-14-9-25-21(11-24-14)16(3)27-22(28)18-6-19(23-26-10-15(2)31-23)8-20(7-18)30-13-17-4-5-29-12-17/h6-11,16-17H,4-5,12-13H2,1-3H3,(H,27,28)/t16-,17+/m1/s1 VCKXOWQZUNTNDF-SJORKVTESA-N 319901 N-[(1R)-1-(5- Methylpyrazin- 2-yl)ethyl]- 3-(5-methyl- 1,3-thiazol-2- yl)-5-[(3S)- tetrahydrofuran- 3-ylmethoxy] benzamide::US10174016, Example 68::US10202369, Example 68::US10472354, Example 68 P2X purinoceptor 3 Homo sapiens 44.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319901 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319901&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397617 384223181 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632132 CC(NC(=O)c1cc(OC[C@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ncc(F)cc1Cl InChI=1S/C23H23ClFN3O3S/c1-13-9-27-23(32-13)17-5-16(6-19(7-17)31-12-15-3-4-30-11-15)22(29)28-14(2)21-20(24)8-18(25)10-26-21/h5-10,14-15H,3-4,11-12H2,1-2H3,(H,28,29)/t14?,15-/m0/s1 UNHVUPCUCRZLRC-LOACHALJSA-N 319902 N-[1-(3- Chloro-5- fluoropyridin- 2-yl)ethyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5-[(3R)- tetrahydrofuran- 3-ylmethoxy] benzamide::US10174016, Example 69::US10202369, Example 69::US10472354, Example 69 P2X purinoceptor 3 Homo sapiens 15.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319902 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319902&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134338444 384223182 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625588 C[C@@H](NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)F InChI=1S/C22H22F2N4O3S/c1-12-8-27-22(32-12)15-5-14(6-18(7-15)31-17-3-4-30-11-17)21(29)28-13(2)16-9-25-20(19(23)24)26-10-16/h5-10,13,17,19H,3-4,11H2,1-2H3,(H,28,29)/t13-,17+/m1/s1 AUVRCFBFFFYNAV-DYVFJYSZSA-N 319984 N-{(1R)-1-[2- (difluoromethyl) pyrimidin-5- yl]ethyl}-3-(5- methyl-1,3- thiazol-2-yl)-5- [(3S)- tetrahydrofuran-3- yloxy]benzamide::US10174016, Example 151::US10202369, Example 151::US10472354, Example 151 P2X purinoceptor 3 Homo sapiens 31.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319984 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319984&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397480 384223264 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625590 C[C@@H](NC(=O)c1cc(OC2COC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)F InChI=1S/C21H20F2N4O3S/c1-11-6-26-21(31-11)14-3-13(4-16(5-14)30-17-9-29-10-17)20(28)27-12(2)15-7-24-19(18(22)23)25-8-15/h3-8,12,17-18H,9-10H2,1-2H3,(H,27,28)/t12-/m1/s1 YTKWIWSPGJOVJL-GFCCVEGCSA-N 319985 N-{(1R)-1-[2- (difluoromethyl) pyrimidin-5- yl]ethyl}-3-(5- methyl-1,3- thiazol-2-yl)-5- (oxetan-3- yloxy)benzamide::US10174016, Example 152::US10202369, Example 152::US10472354, Example 152 P2X purinoceptor 3 Homo sapiens 45.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319985 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319985&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397528 384223265 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625592 C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)F InChI=1S/C22H22F2N4O3S/c1-12-8-27-22(32-12)15-5-14(6-18(7-15)31-17-3-4-30-11-17)21(29)28-13(2)16-9-25-20(19(23)24)26-10-16/h5-10,13,17,19H,3-4,11H2,1-2H3,(H,28,29)/t13-,17-/m1/s1 AUVRCFBFFFYNAV-CXAGYDPISA-N 319986 N-{(1R)-1-[2- (difluoromethyl) pyrimidin-5- yl]ethyl}-3-(5- methyl-1,3- thiazol-2-yl)-5- [(3R)- tetrahydrofuran-3- yloxy]benzamide::US10174016, Example 153::US10202369, Example 153::US10472354, Example 153 P2X purinoceptor 3 Homo sapiens 27.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319986 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319986&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397665 384223266 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625594 C[C@@H](NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)F InChI=1S/C23H24F2N4O3S/c1-13-10-28-23(33-13)16-7-15(8-19(9-16)32-18-3-5-31-6-4-18)22(30)29-14(2)17-11-26-21(20(24)25)27-12-17/h7-12,14,18,20H,3-6H2,1-2H3,(H,29,30)/t14-/m1/s1 RQWRZCMIWXGQJP-CQSZACIVSA-N 319987 N-{(1R)-1-[2- (difluoromethyl) pyrimidin-5- yl]ethyl}-3-(5- methyl-1,3- thiazol-2-yl)-5- (tetrahydro-2H- pyran-4- yloxy)benzamide::US10174016, Example 154::US10202369, Example 154::US10472354, Example 154 P2X purinoceptor 3 Homo sapiens 18.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319987 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319987&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397560 384223267 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625596 C[C@@H](NC(=O)c1cc(O[C@H]2CCCN(C)C2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H26F3N5O2S/c1-14-10-28-22(35-14)17-7-16(8-20(9-17)34-19-5-4-6-32(3)13-19)21(33)31-15(2)18-11-29-23(30-12-18)24(25,26)27/h7-12,15,19H,4-6,13H2,1-3H3,(H,31,33)/t15-,19+/m1/s1 DNVWWBHMIGZIMX-BEFAXECRSA-N 319988 3-{[(3S)-1- methylpiperidin-3- yl]oxy}-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 155::US10174016, Example 221::US10202369, Example 155::US10472354, Example 155 P2X purinoceptor 3 Homo sapiens 40.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319988 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319988&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397794 384223268 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625598 C[C@@H](NC(=O)c1cc(OC2(C)COC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C22H21F3N4O3S/c1-12-7-26-19(33-12)15-4-14(5-17(6-15)32-21(3)10-31-11-21)18(30)29-13(2)16-8-27-20(28-9-16)22(23,24)25/h4-9,13H,10-11H2,1-3H3,(H,29,30)/t13-/m1/s1 OYDLDEWAXBGGBJ-CYBMUJFWSA-N 319989 3-[(3- methyloxetan-3- yl)oxy]-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 156::US10202369, Example 156::US10472354, Example 156 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319989 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319989&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397627 384223269 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625600 C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ccc(nc1)C(F)(F)F InChI=1S/C23H22F3N3O3S/c1-13-10-28-22(33-13)17-7-16(8-19(9-17)32-18-5-6-31-12-18)21(30)29-14(2)15-3-4-20(27-11-15)23(24,25)26/h3-4,7-11,14,18H,5-6,12H2,1-2H3,(H,29,30)/t14-,18-/m1/s1 RHAXZNLWUJRHEA-RDTXWAMCSA-N 319990 3-(5-methyl-1,3- thiazol-2-yl)-5- [(3R)- tetrahydrofuran-3- yloxy]-N-{(1R)-1- [6- (trifluoromethyl) pyridin-3- yl]ethyl}benzamide::US10174016, Example 157::US10202369, Example 157::US10472354, Example 157 P2X purinoceptor 3 Homo sapiens 17.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319990 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319990&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397372 384223270 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625602 C[C@@H](NC(=O)c1cc(O[C@@H]2CCCN(C)C2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H26F3N5O2S/c1-14-10-28-22(35-14)17-7-16(8-20(9-17)34-19-5-4-6-32(3)13-19)21(33)31-15(2)18-11-29-23(30-12-18)24(25,26)27/h7-12,15,19H,4-6,13H2,1-3H3,(H,31,33)/t15-,19-/m1/s1 DNVWWBHMIGZIMX-DNVCBOLYSA-N 319991 3-{[(3R)-1- methylpiperidin-3- yl]oxy}-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 158::US10174016, Example 220::US10202369, Example 158::US10472354, Example 158 P2X purinoceptor 3 Homo sapiens 21.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319991 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319991&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397414 384223271 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625604 C[C@@H](NC(=O)c1cc(OCCn2cncn2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C22H20F3N7O2S/c1-13-8-27-20(35-13)16-5-15(6-18(7-16)34-4-3-32-12-26-11-30-32)19(33)31-14(2)17-9-28-21(29-10-17)22(23,24)25/h5-12,14H,3-4H2,1-2H3,(H,31,33)/t14-/m1/s1 HYNLHPVSAUUUKN-CQSZACIVSA-N 319992 3-(5-methyl-1,3- thiazol-2-yl)-5-[2- (1H-1,2,4-triazol- 1-yl)ethoxy]-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 159::US10202369, Example 159::US10472354, Example 159 P2X purinoceptor 3 Homo sapiens 28.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319992 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319992&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397126 384223272 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625606 C[C@@H](NC(=O)c1cc(OCCn2cncn2)cc(c1)-c1ncc(C)s1)c1ccc(nc1)C(F)(F)F InChI=1S/C23H21F3N6O2S/c1-14-10-29-22(35-14)18-7-17(8-19(9-18)34-6-5-32-13-27-12-30-32)21(33)31-15(2)16-3-4-20(28-11-16)23(24,25)26/h3-4,7-13,15H,5-6H2,1-2H3,(H,31,33)/t15-/m1/s1 ZEDPNXXTTLJFPM-OAHLLOKOSA-N 319993 3-(5-methyl-1,3- thiazol-2-yl)-5-[2- (1H-1,2,4-triazol- 1-yl)ethoxy]-N- {(1R)-1-[6- (trifluoromethyl) pyridin-3- yl]ethyl}benzamide::US10174016, Example 160::US10202369, Example 160::US10472354, Example 160 P2X purinoceptor 3 Homo sapiens 28.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319993 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319993&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397838 384223273 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625608 C[C@@H](NC(=O)c1cc(OC2COC2)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F InChI=1S/C21H19F3N4O3S/c1-11-8-25-20(32-11)14-5-13(6-15(7-14)31-16-9-30-10-16)19(29)26-12(2)17-3-4-18(28-27-17)21(22,23)24/h3-8,12,16H,9-10H2,1-2H3,(H,26,29)/t12-/m1/s1 GINDYDBHFAVPIL-GFCCVEGCSA-N 319994 3-(5-methyl-1,3- thiazol-2-yl)-5- (oxetan-3-yloxy)- N-{(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl}benzamide::US10174016, Example 161::US10202369, Example 161::US10472354, Example 161 P2X purinoceptor 3 Homo sapiens 32.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319994 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319994&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397757 384223274 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625610 CC(O)C(C)Oc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C22H23F3N4O3S/c1-11-8-26-20(33-11)16-5-15(6-18(7-16)32-14(4)13(3)30)19(31)29-12(2)17-9-27-21(28-10-17)22(23,24)25/h5-10,12-14,30H,1-4H3,(H,29,31)/t12-,13?,14?/m1/s1 FSGDRFBLPAILDE-IYXRBSQSSA-N 319995 3-{[3-hydroxybutan-2-yl]oxy}-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 162::US10174016, Example 338::US10202369, Example 339::US10472354, Example 338 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319995 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319995&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397269 384223275 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625612 CC(O)C(C)Oc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C22H23F3N4O3S/c1-11-8-26-20(33-11)16-5-15(6-18(7-16)32-14(4)13(3)30)19(31)29-12(2)17-9-27-21(28-10-17)22(23,24)25/h5-10,12-14,30H,1-4H3,(H,29,31)/t12-,13?,14?/m0/s1 FSGDRFBLPAILDE-HSBZDZAISA-N 319996 US10174016, Example 163::US10202369, Example 340::US10472354, Example 162 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319996 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319996&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134328174 384223276 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625614 C[C@@H](NC(=O)c1cc(OC2COC2)cc(c1)-c1ncc(C)s1)c1ccc(nc1)C(F)F InChI=1S/C22H21F2N3O3S/c1-12-8-26-22(31-12)16-5-15(6-17(7-16)30-18-10-29-11-18)21(28)27-13(2)14-3-4-19(20(23)24)25-9-14/h3-9,13,18,20H,10-11H2,1-2H3,(H,27,28)/t13-/m1/s1 VIFFUASYGYMCSF-CYBMUJFWSA-N 319997 N-{[(1R)-1-[6- (difluoromethyl) pyridin-3-yl]ethyl}-3- (5-methyl-1,3- thiazol-2-yl)-5- (oxetan-3- yloxy)benzamide::US10174016, Example 164::US10202369, Example 164::US10472354, Example 164 P2X purinoceptor 3 Homo sapiens 60.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319997 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319997&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397252 384223277 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625616 C[C@@H](NC(=O)c1cc(O[C@H]2C[C@@H](C2)N(C)C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H26F3N5O2S/c1-13-10-28-22(35-13)16-5-15(6-19(7-16)34-20-8-18(9-20)32(3)4)21(33)31-14(2)17-11-29-23(30-12-17)24(25,26)27/h5-7,10-12,14,18,20H,8-9H2,1-4H3,(H,31,33)/t14-,18-,20-/m1/s1 AGHYBRFMKRJHNY-LXGCGDOSSA-N 319998 3-{[trans-3- (dimethylamino) cyclobutyl]oxy}-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5-yl] ethyl}benzamide::US10174016, Example 165::US10202369, Example 165::US10472354, Example 165 P2X purinoceptor 3 Homo sapiens 81.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319998 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319998&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397549 384223278 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625618 Cc1cnc(s1)-c1cc(O[C@@H]2CCOC2)cc(c1)C(=O)NCc1cnc(nc1)C(F)(F)F InChI=1S/C21H19F3N4O3S/c1-12-7-26-19(32-12)15-4-14(5-17(6-15)31-16-2-3-30-11-16)18(29)25-8-13-9-27-20(28-10-13)21(22,23)24/h4-7,9-10,16H,2-3,8,11H2,1H3,(H,25,29)/t16-/m1/s1 MLKRPMMAEMGGNI-MRXNPFEDSA-N 319999 3-(5-methyl-1,3- thiazol-2-yl)-5- [(3R)- tetrahydrofuran-3- yloxy]-N-{[2- (trifluoromethyl) pyrimidin-5- yl]methyl}benzamide::US10174016, Example 166::US10202369, Example 166::US10472354, Example 166 P2X purinoceptor 3 Homo sapiens 40.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319999 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319999&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397360 384223279 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625620 Cc1cnc(s1)-c1cc(OC2COC2)cc(c1)C(=O)NCc1cnc(nc1)C(F)(F)F InChI=1S/C20H17F3N4O3S/c1-11-5-25-18(31-11)14-2-13(3-15(4-14)30-16-9-29-10-16)17(28)24-6-12-7-26-19(27-8-12)20(21,22)23/h2-5,7-8,16H,6,9-10H2,1H3,(H,24,28) AWMOXCQCRBHEDH-UHFFFAOYSA-N 320000 3-(5-methyl-1,3- thiazol-2-yl)-5- (oxetan-3-yloxy)- N-{[2- (trifluoromethyl) pyrimidin-5- yl]methyl}benzamide::US10174016, Example 167::US10202369, Example 167::US10472354, Example 167 P2X purinoceptor 3 Homo sapiens 72.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320000 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320000&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397228 384223280 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625622 C[C@@H](NC(=O)c1cc(O[C@H]2CN3CCC2CC3)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C25H26F3N5O2S/c1-14-10-29-23(36-14)18-7-17(8-20(9-18)35-21-13-33-5-3-16(21)4-6-33)22(34)32-15(2)19-11-30-24(31-12-19)25(26,27)28/h7-12,15-16,21H,3-6,13H2,1-2H3,(H,32,34)/t15-,21+/m1/s1 XGNFOBIXAZWFEF-VFNWGFHPSA-N 320001 3-[(3R)-1- azabicyclo[2.2.2] oct-3-yloxy]-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 168::US10202369, Example 168::US10472354, Example 168 P2X purinoceptor 3 Homo sapiens 19.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320001 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320001&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397190 384223281 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625624 CCc1cnc(s1)-c1cc(OC2COC2)cc(c1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C22H21F3N4O3S/c1-3-18-9-26-20(33-18)14-4-13(5-16(6-14)32-17-10-31-11-17)19(30)29-12(2)15-7-27-21(28-8-15)22(23,24)25/h4-9,12,17H,3,10-11H2,1-2H3,(H,29,30)/t12-/m1/s1 KJLXSAGNAKDMHX-GFCCVEGCSA-N 320002 3-(5-ethyl-1,3- thiazol-2-yl)-5- (oxetan-3-yloxy)- N-{(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 169::US10202369, Example 169::US10472354, Example 169 P2X purinoceptor 3 Homo sapiens 9.00 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320002 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320002&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397192 384223282 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625626 C[C@@H](NC(=O)c1cc(Oc2ccc(C)nn2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H19F3N6O2S/c1-12-4-5-19(32-31-12)34-18-7-15(6-16(8-18)21-27-9-13(2)35-21)20(33)30-14(3)17-10-28-22(29-11-17)23(24,25)26/h4-11,14H,1-3H3,(H,30,33)/t14-/m1/s1 YBWKZVABJNKBEG-CQSZACIVSA-N 320003 3-[(6- methylpyridazin-3- yl)oxy]-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 170::US10202369, Example 170::US10472354, Example 170 P2X purinoceptor 3 Homo sapiens 165 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320003 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320003&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397298 384223283 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625628 C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ccc(nc1)C(F)F InChI=1S/C23H23F2N3O3S/c1-13-10-27-23(32-13)17-7-16(8-19(9-17)31-18-5-6-30-12-18)22(29)28-14(2)15-3-4-20(21(24)25)26-11-15/h3-4,7-11,14,18,21H,5-6,12H2,1-2H3,(H,28,29)/t14-,18-/m1/s1 UIFKRKFOSZCXTP-RDTXWAMCSA-N 320004 N-{(1R)-1-[6- (difluoromethyl) pyridin-3-yl]ethyl}-3- (5-methyl-1,3- thiazol-2-yl)-5- [(3R)- tetrahydrofuran-3- yloxy]benzamide::US10174016, Example 171::US10202369, Example 171::US10472354, Example 171 P2X purinoceptor 3 Homo sapiens 26.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320004 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320004&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397544 384223284 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625630 C[C@@H](NC(=O)c1cc(O[C@H]2CN3CCC2CC3)cc(c1)-c1ncc(C)s1)c1ccc(nc1)C(F)(F)F InChI=1S/C26H27F3N4O2S/c1-15-12-31-25(36-15)20-9-19(10-21(11-20)35-22-14-33-7-5-17(22)6-8-33)24(34)32-16(2)18-3-4-23(30-13-18)26(27,28)29/h3-4,9-13,16-17,22H,5-8,14H2,1-2H3,(H,32,34)/t16-,22+/m1/s1 BTZKHRISYBAOIH-ZHRRBRCNSA-N 320005 3-[(3R)-1- azabicyclo[2.2.2] oct-3-yloxy]-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[6- (trifluoromethyl) pyridin-3- yl]ethyl}benzamide::US10174016, Example 172::US10202369, Example 172::US10472354, Example 172 P2X purinoceptor 3 Homo sapiens 31.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320005 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320005&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397643 384223285 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625632 CCc1cnc(s1)-c1cc(O[C@@H]2CN3CCC2CC3)cc(c1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C26H28F3N5O2S/c1-3-21-13-30-24(37-21)18-8-17(9-20(10-18)36-22-14-34-6-4-16(22)5-7-34)23(35)33-15(2)19-11-31-25(32-12-19)26(27,28)29/h8-13,15-16,22H,3-7,14H2,1-2H3,(H,33,35)/t15-,22-/m1/s1 SVMXJSAEFPTNIN-IVZQSRNASA-N 320006 3-[(3S)-1- azabicyclo[2.2.2] oct-3-yloxy]-5-(5- ethyl-1,3-thiazol- 2-yl)-N-{(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 173::US10202369, Example 173::US10472354, Example 173 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320006 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320006&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397592 384223286 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625634 CCc1cnc(s1)-c1cc(O[C@H]2CN3CCC2CC3)cc(c1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C26H28F3N5O2S/c1-3-21-13-30-24(37-21)18-8-17(9-20(10-18)36-22-14-34-6-4-16(22)5-7-34)23(35)33-15(2)19-11-31-25(32-12-19)26(27,28)29/h8-13,15-16,22H,3-7,14H2,1-2H3,(H,33,35)/t15-,22+/m1/s1 SVMXJSAEFPTNIN-QRQCRPRQSA-N 320007 3-[(3R)-1- azabicyclo[2.2.2] oct-3-yloxy]-5-(5- ethyl-1,3-thiazol- 2-yl)-N-{(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 174::US10202369, Example 174::US10472354, Example 174 P2X purinoceptor 3 Homo sapiens 11.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320007 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320007&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397479 384223287 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625636 C[C@@H](NC(=O)c1cc(O[C@@H]2CN3CCC2CC3)cc(c1)-c1ncc(C)s1)c1ccc(nc1)C(F)(F)F InChI=1S/C26H27F3N4O2S/c1-15-12-31-25(36-15)20-9-19(10-21(11-20)35-22-14-33-7-5-17(22)6-8-33)24(34)32-16(2)18-3-4-23(30-13-18)26(27,28)29/h3-4,9-13,16-17,22H,5-8,14H2,1-2H3,(H,32,34)/t16-,22-/m1/s1 BTZKHRISYBAOIH-OPAMFIHVSA-N 320008 3-[(3S)-1- azabicyclo[2.2.2] oct-3-yloxy]-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[6- (trifluoromethyl) pyridin-3- yl]ethyl}benzamide::US10174016, Example 175::US10202369, Example 175::US10472354, Example 175 P2X purinoceptor 3 Homo sapiens 23.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320008 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320008&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397558 384223288 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625638 C[C@@H](NC(=O)c1cc(Oc2nnc(C)s2)cc(c1)-c1ncc(C)s1)c1ccc(nc1)C(F)(F)F InChI=1S/C22H18F3N5O2S2/c1-11-9-27-20(33-11)16-6-15(7-17(8-16)32-21-30-29-13(3)34-21)19(31)28-12(2)14-4-5-18(26-10-14)22(23,24)25/h4-10,12H,1-3H3,(H,28,31)/t12-/m1/s1 IWXLKQRNUPTLAV-GFCCVEGCSA-N 320009 3-[(5-methyl- 1,3,4-thiadiazol-2- yl)oxy]-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[6- (trifluoromethyl) pyridin-3- yl]ethyl}benzamide::US10174016, Example 176::US10202369, Example 176::US10472354, Example 176 P2X purinoceptor 3 Homo sapiens 29.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320009 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320009&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397692 384223289 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625640 C[C@@H](NC(=O)c1cc(OC[C@H]2COCCO2)cc(c1)-c1ncc(C)s1)c1ccc(nc1)C(F)(F)F InChI=1S/C24H24F3N3O4S/c1-14-10-29-23(35-14)18-7-17(8-19(9-18)34-13-20-12-32-5-6-33-20)22(31)30-15(2)16-3-4-21(28-11-16)24(25,26)27/h3-4,7-11,15,20H,5-6,12-13H2,1-2H3,(H,30,31)/t15-,20-/m1/s1 LZEBVIBIWJOALL-FOIQADDNSA-N 320010 3-[(2R)-1,4-dioxan-2- ylmethoxy]-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[6- (trifluoromethyl) pyridin-3- yl]ethyl}benzamide::US10174016, Example 177::US10202369, Example 177::US10472354, Example 177 P2X purinoceptor 3 Homo sapiens 14.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320010 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320010&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397515 384223290 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625642 C[C@@H](NC(=O)c1cc(OC[C@H]2COCCO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H23F3N4O4S/c1-13-8-27-21(35-13)16-5-15(6-18(7-16)34-12-19-11-32-3-4-33-19)20(31)30-14(2)17-9-28-22(29-10-17)23(24,25)26/h5-10,14,19H,3-4,11-12H2,1-2H3,(H,30,31)/t14-,19-/m1/s1 NQEFGEXCJWOEFF-AUUYWEPGSA-N 320011 3-[(2R)-1,4-dioxan-2- ylmethoxy]-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 178::US10202369, Example 178::US10472354, Example 178 P2X purinoceptor 3 Homo sapiens 39.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320011 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320011&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397229 384223291 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625644 C[C@@H](NC(=O)c1cc(OC[C@H]2COCCO2)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F InChI=1S/C23H23F3N4O4S/c1-13-10-27-22(35-13)16-7-15(8-17(9-16)34-12-18-11-32-5-6-33-18)21(31)28-14(2)19-3-4-20(30-29-19)23(24,25)26/h3-4,7-10,14,18H,5-6,11-12H2,1-2H3,(H,28,31)/t14-,18-/m1/s1 PZDPWIRLHUGUOG-RDTXWAMCSA-N 320012 3-[(2R)-1,4-dioxan-2- ylmethoxy]-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3-yl]ethyl} benzamide::US10174016, Example 179::US10202369, Example 179::US10472354, Example 179 P2X purinoceptor 3 Homo sapiens 13.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320012 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320012&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397371 384223292 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625646 C[C@@H](NC(=O)c1cc(OC[C@@H]2COCCO2)cc(c1)-c1ncc(C)s1)c1ccc(nc1)C(F)(F)F InChI=1S/C24H24F3N3O4S/c1-14-10-29-23(35-14)18-7-17(8-19(9-18)34-13-20-12-32-5-6-33-20)22(31)30-15(2)16-3-4-21(28-11-16)24(25,26)27/h3-4,7-11,15,20H,5-6,12-13H2,1-2H3,(H,30,31)/t15-,20+/m1/s1 LZEBVIBIWJOALL-QRWLVFNGSA-N 320013 3-[(2S)-1,4-dioxan- 2-ylmethoxy]-5-(5- methyl-1,3-thiazol-2-yl)- N-{(1R)-1-[6- (trifluoromethyl)pyridin- 3-yl]ethyl}benzamide::US10174016, Example 180::US10202369, Example 180::US10472354, Example 180 P2X purinoceptor 3 Homo sapiens 31.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320013 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320013&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397137 384223293 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625648 C[C@@H](NC(=O)c1cc(OC[C@@H]2COCCO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H23F3N4O4S/c1-13-8-27-21(35-13)16-5-15(6-18(7-16)34-12-19-11-32-3-4-33-19)20(31)30-14(2)17-9-28-22(29-10-17)23(24,25)26/h5-10,14,19H,3-4,11-12H2,1-2H3,(H,30,31)/t14-,19+/m1/s1 NQEFGEXCJWOEFF-KUHUBIRLSA-N 320014 3-[(2S)-1,4-dioxan- 2-ylmethoxy]-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 181::US10202369, Example 181::US10472354, Example 181 P2X purinoceptor 3 Homo sapiens 19.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320014 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320014&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397128 384223294 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625650 C[C@@H](NC(=O)c1cc(OC[C@@H]2COCCO2)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F InChI=1S/C23H23F3N4O4S/c1-13-10-27-22(35-13)16-7-15(8-17(9-16)34-12-18-11-32-5-6-33-18)21(31)28-14(2)19-3-4-20(30-29-19)23(24,25)26/h3-4,7-10,14,18H,5-6,11-12H2,1-2H3,(H,28,31)/t14-,18+/m1/s1 PZDPWIRLHUGUOG-KDOFPFPSSA-N 320015 3-[(2S)-1,4-dioxan- 2-ylmethoxy]-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl}benzamide::US10174016, Example 182::US10202369, Example 182::US10472354, Example 182 P2X purinoceptor 3 Homo sapiens 63.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320015 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320015&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397642 384223295 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625652 CC(O)C(C)Oc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1ccc(nn1)C(F)(F)F InChI=1S/C22H23F3N4O3S/c1-11-10-26-21(33-11)16-7-15(8-17(9-16)32-14(4)13(3)30)20(31)27-12(2)18-5-6-19(29-28-18)22(23,24)25/h5-10,12-14,30H,1-4H3,(H,27,31)/t12-,13?,14?/m1/s1 LMHZXBDHIYABCN-IYXRBSQSSA-N 320016 Trans Isomer 1; 3- {[3-hydroxybutan- 2-yl]oxy}-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl}benzamide::US10174016, Example 183::US10202369, Example 230::US10472354, Example 231 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320016 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320016&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397175 384223296 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625654 CC(O)C(C)Oc1cc(cc(c1)-c1ncc(Cl)s1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C21H20ClF3N4O3S/c1-10(15-7-27-20(28-8-15)21(23,24)25)29-18(31)13-4-14(19-26-9-17(22)33-19)6-16(5-13)32-12(3)11(2)30/h4-12,30H,1-3H3,(H,29,31)/t10-,11?,12?/m1/s1 QTLJKKFADUZLKR-VOMCLLRMSA-N 320017 Trans Isomer 1; 3- (5-chloro-1,3- thiazol-2-yl)-5-{[3- hydroxybutan-2- yl]oxy}-N-{(1R)-1- [2-(trifluoromethyl) pyrimidin-5-yl]ethyl} benzamide::US10174016, Example 184::US10174016, Example 185::US10174016, Example 187::US10174016, Example 188::US10202369, Example 188::US10472354, Example 188 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320017 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320017&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397494 384223297 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625656 CC(O)C(C)Oc1cc(cc(c1)-c1ncc(Cl)s1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C21H20ClF3N4O3S/c1-10(15-7-27-20(28-8-15)21(23,24)25)29-18(31)13-4-14(19-26-9-17(22)33-19)6-16(5-13)32-12(3)11(2)30/h4-12,30H,1-3H3,(H,29,31)/t10-,11?,12?/m1/s1 QTLJKKFADUZLKR-VOMCLLRMSA-N 320017 Trans Isomer 1; 3- (5-chloro-1,3- thiazol-2-yl)-5-{[3- hydroxybutan-2- yl]oxy}-N-{(1R)-1- [2-(trifluoromethyl) pyrimidin-5-yl]ethyl} benzamide::US10174016, Example 184::US10174016, Example 185::US10174016, Example 187::US10174016, Example 188::US10202369, Example 188::US10472354, Example 188 P2X purinoceptor 3 Homo sapiens 4.00 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320017 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320017&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397494 384223297 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625658 CC(O)C(C)Oc1cc(cc(c1)-c1ncc(Cl)s1)C(=O)N[C@H](C)c1ccc(nc1)C(F)(F)F InChI=1S/C22H21ClF3N3O3S/c1-11(14-4-5-18(27-9-14)22(24,25)26)29-20(31)15-6-16(21-28-10-19(23)33-21)8-17(7-15)32-13(3)12(2)30/h4-13,30H,1-3H3,(H,29,31)/t11-,12?,13?/m1/s1 HTVWJAQZHONFAU-PNESKVBLSA-N 320019 Trans Isomer 1; 3- (5-chloro-1,3- thiazol-2-yl)-5-{[3- hydroxybutan-2- yl]oxy}-N-{(1R)-1- [6-(trifluoromethyl) pyridin-3-yl]ethyl} benzamide::US10174016, Example 186::US10174016, Example 189::US10202369, Example 189::US10472354, Example 189 P2X purinoceptor 3 Homo sapiens 10.00 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320019 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320019&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397322 384223298 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625660 CC(O)C(C)Oc1cc(cc(c1)-c1ncc(Cl)s1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C21H20ClF3N4O3S/c1-10(15-7-27-20(28-8-15)21(23,24)25)29-18(31)13-4-14(19-26-9-17(22)33-19)6-16(5-13)32-12(3)11(2)30/h4-12,30H,1-3H3,(H,29,31)/t10-,11?,12?/m1/s1 QTLJKKFADUZLKR-VOMCLLRMSA-N 320017 Trans Isomer 1; 3- (5-chloro-1,3- thiazol-2-yl)-5-{[3- hydroxybutan-2- yl]oxy}-N-{(1R)-1- [2-(trifluoromethyl) pyrimidin-5-yl]ethyl} benzamide::US10174016, Example 184::US10174016, Example 185::US10174016, Example 187::US10174016, Example 188::US10202369, Example 188::US10472354, Example 188 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320017 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320017&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397494 384223297 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625662 CC(O)C(C)Oc1cc(cc(c1)-c1ncc(Cl)s1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C21H20ClF3N4O3S/c1-10(15-7-27-20(28-8-15)21(23,24)25)29-18(31)13-4-14(19-26-9-17(22)33-19)6-16(5-13)32-12(3)11(2)30/h4-12,30H,1-3H3,(H,29,31)/t10-,11?,12?/m1/s1 QTLJKKFADUZLKR-VOMCLLRMSA-N 320017 Trans Isomer 1; 3- (5-chloro-1,3- thiazol-2-yl)-5-{[3- hydroxybutan-2- yl]oxy}-N-{(1R)-1- [2-(trifluoromethyl) pyrimidin-5-yl]ethyl} benzamide::US10174016, Example 184::US10174016, Example 185::US10174016, Example 187::US10174016, Example 188::US10202369, Example 188::US10472354, Example 188 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320017 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320017&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397494 384223297 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625664 CC(O)C(C)Oc1cc(cc(c1)-c1ncc(Cl)s1)C(=O)N[C@H](C)c1ccc(nc1)C(F)(F)F InChI=1S/C22H21ClF3N3O3S/c1-11(14-4-5-18(27-9-14)22(24,25)26)29-20(31)15-6-16(21-28-10-19(23)33-21)8-17(7-15)32-13(3)12(2)30/h4-13,30H,1-3H3,(H,29,31)/t11-,12?,13?/m1/s1 HTVWJAQZHONFAU-PNESKVBLSA-N 320019 Trans Isomer 1; 3- (5-chloro-1,3- thiazol-2-yl)-5-{[3- hydroxybutan-2- yl]oxy}-N-{(1R)-1- [6-(trifluoromethyl) pyridin-3-yl]ethyl} benzamide::US10174016, Example 186::US10174016, Example 189::US10202369, Example 189::US10472354, Example 189 P2X purinoceptor 3 Homo sapiens 8.00 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320019 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320019&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397322 384223298 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625666 C[C@@H](NC(=O)c1cc(OC2CCCN(C2)C(=O)OC(C)(C)C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C28H32F3N5O4S/c1-16-12-32-24(41-16)19-9-18(23(37)35-17(2)20-13-33-25(34-14-20)28(29,30)31)10-22(11-19)39-21-7-6-8-36(15-21)26(38)40-27(3,4)5/h9-14,17,21H,6-8,15H2,1-5H3,(H,35,37)/t17-,21?/m1/s1 GMVSECYUKAWWNE-OQHSHRKDSA-N 320023 US10174016, Example 190::US10202369, Example 190::US10472354, Example 190::tert-Butyl (3R)-3-[3-(5-methyl-1,3-thiazol-2-yl)-5-({(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}carbamoyl)phenoxy]piperidine-1-carboxylate, as a mixture of diastereoisomers P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320023 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320023&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134338447 384223299 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625668 CC#CCOc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1ccc(C)nn1 InChI=1S/C22H22N4O2S/c1-5-6-9-28-19-11-17(10-18(12-19)22-23-13-15(3)29-22)21(27)24-16(4)20-8-7-14(2)25-26-20/h7-8,10-13,16H,9H2,1-4H3,(H,24,27)/t16-/m1/s1 WEKOJPFCJMIPGB-MRXNPFEDSA-N 320024 3-(but-2-yn-1- yloxy)-N-[(1R)- 1-(6- methylpyridazin- 3- yl)ethyl]-5- (5-methyl- 1,3-thiazol-2-yl) benzamide::US10174016, Example 191::US10202369, Example 191::US10472354, Example 191 P2X purinoceptor 3 Homo sapiens 61.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320024 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320024&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397657 384223300 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625670 C[C@@H](NC(=O)c1cc(O[C@@H]2CN3CCC2CC3)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C25H26F3N5O2S/c1-14-10-29-23(36-14)18-7-17(8-20(9-18)35-21-13-33-5-3-16(21)4-6-33)22(34)32-15(2)19-11-30-24(31-12-19)25(26,27)28/h7-12,15-16,21H,3-6,13H2,1-2H3,(H,32,34)/t15-,21-/m1/s1 XGNFOBIXAZWFEF-QVKFZJNVSA-N 320025 3-[(3S)-1- azabicyclo[2.2.2] oct-3-yloxy]-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5-yl] ethyl} benzamide::US10174016, Example 192::US10202369, Example 192::US10472354, Example 192 P2X purinoceptor 3 Homo sapiens 12.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320025 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320025&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397263 384223301 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625672 C[C@@H](NC(=O)c1cc(OC2COC2)cc(c1)-c1ncc(C)s1)c1nnc(s1)C(F)(F)F InChI=1S/C19H17F3N4O3S2/c1-9-6-23-17(30-9)12-3-11(4-13(5-12)29-14-7-28-8-14)15(27)24-10(2)16-25-26-18(31-16)19(20,21)22/h3-6,10,14H,7-8H2,1-2H3,(H,24,27)/t10-/m1/s1 CAKLWYTTWVXMCY-SNVBAGLBSA-N 320026 3-(5-Methyl-1,3-thiazol-2-yl)-5-(oxetan-3-yloxy)-N-{1-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]ethyl}benzamide::US10174016, Example 193::US10202369, Example 194::US10472354, Example 194 P2X purinoceptor 3 Homo sapiens 2705 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320026 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320026&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 138374896 384223302 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625674 C[C@H](NC(=O)c1cc(OC2COC2)cc(c1)-c1ncc(C)s1)c1nnc(s1)C(F)(F)F InChI=1S/C19H17F3N4O3S2/c1-9-6-23-17(30-9)12-3-11(4-13(5-12)29-14-7-28-8-14)15(27)24-10(2)16-25-26-18(31-16)19(20,21)22/h3-6,10,14H,7-8H2,1-2H3,(H,24,27)/t10-/m0/s1 CAKLWYTTWVXMCY-JTQLQIEISA-N 320027 US10174016, Example 194::US10202369, Example 193::US10472354, Example 193 P2X purinoceptor 3 Homo sapiens 46.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320027 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320027&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 138374897 384223303 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625676 C[C@@H](NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(C)s1)c1nnc(s1)C(F)(F)F InChI=1S/C21H21F3N4O3S2/c1-11-10-25-19(32-11)14-7-13(8-16(9-14)31-15-3-5-30-6-4-15)17(29)26-12(2)18-27-28-20(33-18)21(22,23)24/h7-10,12,15H,3-6H2,1-2H3,(H,26,29)/t12-/m1/s1 NWTVSPCFEGLAFO-GFCCVEGCSA-N 320028 3-(5-methyl-1,3-thiazol-2-yl)-5-(tetrahydro-2H-pyran-4-yloxy)-N-{1-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]ethyl}benzamide::US10174016, Example 195::US10202369, Example 196::US10472354, Example 196 P2X purinoceptor 3 Homo sapiens 380 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320028 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320028&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 138374898 384223304 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625678 C[C@H](NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(C)s1)c1nnc(s1)C(F)(F)F InChI=1S/C21H21F3N4O3S2/c1-11-10-25-19(32-11)14-7-13(8-16(9-14)31-15-3-5-30-6-4-15)17(29)26-12(2)18-27-28-20(33-18)21(22,23)24/h7-10,12,15H,3-6H2,1-2H3,(H,26,29)/t12-/m0/s1 NWTVSPCFEGLAFO-LBPRGKRZSA-N 320029 US10174016, Example 196::US10202369, Example 195::US10472354, Example 195 P2X purinoceptor 3 Homo sapiens 19.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320029 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320029&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 138374899 384223305 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625680 C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1nnc(s1)C(F)(F)F InChI=1S/C20H19F3N4O3S2/c1-10-8-24-18(31-10)13-5-12(6-15(7-13)30-14-3-4-29-9-14)16(28)25-11(2)17-26-27-19(32-17)20(21,22)23/h5-8,11,14H,3-4,9H2,1-2H3,(H,25,28)/t11-,14-/m1/s1 SHLRNWXFYHGFLL-BXUZGUMPSA-N 320030 3-(5-methyl-1,3-thiazol-2-yl)-5-[(3R)-tetrahydrofuran-3-yloxy]-N-{1-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]ethyl}benzamide::US10174016, Example 197::US10202369, Example 198::US10472354, Example 198 P2X purinoceptor 3 Homo sapiens 1152 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320030 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320030&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397585 384223306 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625682 C[C@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1nnc(s1)C(F)(F)F InChI=1S/C20H19F3N4O3S2/c1-10-8-24-18(31-10)13-5-12(6-15(7-13)30-14-3-4-29-9-14)16(28)25-11(2)17-26-27-19(32-17)20(21,22)23/h5-8,11,14H,3-4,9H2,1-2H3,(H,25,28)/t11-,14+/m0/s1 SHLRNWXFYHGFLL-SMDDNHRTSA-N 320031 US10174016, Example 198::US10202369, Example 197::US10472354, Example 197 P2X purinoceptor 3 Homo sapiens 30.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320031 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320031&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 138374900 384223307 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625684 C[C@@H](NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1nnc(s1)C(F)(F)F InChI=1S/C20H19F3N4O3S2/c1-10-8-24-18(31-10)13-5-12(6-15(7-13)30-14-3-4-29-9-14)16(28)25-11(2)17-26-27-19(32-17)20(21,22)23/h5-8,11,14H,3-4,9H2,1-2H3,(H,25,28)/t11-,14+/m1/s1 SHLRNWXFYHGFLL-RISCZKNCSA-N 320032 3-(5-methyl-1,3-thiazol-2-yl)-5-[(3S)-tetrahydrofuran-3-yloxy]-N-{1-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]ethyl}benzamide::US10174016, Example 199::US10202369, Example 200::US10472354, Example 200 P2X purinoceptor 3 Homo sapiens 1544 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320032 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320032&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397243 384223308 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625686 C[C@H](NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1nnc(s1)C(F)(F)F InChI=1S/C20H19F3N4O3S2/c1-10-8-24-18(31-10)13-5-12(6-15(7-13)30-14-3-4-29-9-14)16(28)25-11(2)17-26-27-19(32-17)20(21,22)23/h5-8,11,14H,3-4,9H2,1-2H3,(H,25,28)/t11-,14-/m0/s1 SHLRNWXFYHGFLL-FZMZJTMJSA-N 320033 US10174016, Example 200::US10202369, Example 199::US10472354, Example 199 P2X purinoceptor 3 Homo sapiens 30.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320033 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320033&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 138374901 384223309 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625688 C[C@@H](NC(=O)c1cc(OC2CCNCC2)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F InChI=1S/C23H24F3N5O2S/c1-13-12-28-22(34-13)16-9-15(10-18(11-16)33-17-5-7-27-8-6-17)21(32)29-14(2)19-3-4-20(31-30-19)23(24,25)26/h3-4,9-12,14,17,27H,5-8H2,1-2H3,(H,29,32)/t14-/m1/s1 JTGZQMREWDOCMX-CQSZACIVSA-N 320034 3-(5-methyl-1,3-thiazol-2-yl)-5-(piperidin-4-yloxy)-N-{(1R)-1-[6-(trifluoromethyl)pyridazin-3-yl]ethyl}benzamide::US10174016, Example 201::US10202369, Example 201::US10472354, Example 201 P2X purinoceptor 3 Homo sapiens 16.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320034 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320034&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397404 384223310 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625690 C[C@@H](NC(=O)c1cc(OC2CC3(CNC3)C2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H24F3N5O2S/c1-13-8-29-21(35-13)16-3-15(4-18(5-16)34-19-6-23(7-19)11-28-12-23)20(33)32-14(2)17-9-30-22(31-10-17)24(25,26)27/h3-5,8-10,14,19,28H,6-7,11-12H2,1-2H3,(H,32,33)/t14-/m1/s1 KMHSWHWDZALJOK-CQSZACIVSA-N 320035 3-(2- azaspiro[3.3] hept- 6-yloxy)-5-(5- methyl-1,3- thiazol-2- yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 202::US10202369, Example 202::US10472354, Example 202 P2X purinoceptor 3 Homo sapiens 42.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320035 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320035&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397731 384223311 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625692 C[C@@H](NC(=O)c1cc(O[C@H]2CCNC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C22H22F3N5O2S/c1-12-8-27-20(33-12)15-5-14(6-18(7-15)32-17-3-4-26-11-17)19(31)30-13(2)16-9-28-21(29-10-16)22(23,24)25/h5-10,13,17,26H,3-4,11H2,1-2H3,(H,30,31)/t13-,17+/m1/s1 IUOVXWVSORDTAX-DYVFJYSZSA-N 320036 3-(5-methyl- 1,3-thiazol-2- yl)-5-[(3S)- pyrrolidin-3- yloxy]-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 203::US10202369, Example 203::US10472354, Example 203 P2X purinoceptor 3 Homo sapiens 36.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320036 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320036&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397829 384223312 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625694 C[C@@H](NC(=O)c1cc(OC2CCNCC2F)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H23F4N5O2S/c1-12-8-29-21(35-12)15-5-14(6-17(7-15)34-19-3-4-28-11-18(19)24)20(33)32-13(2)16-9-30-22(31-10-16)23(25,26)27/h5-10,13,18-19,28H,3-4,11H2,1-2H3,(H,32,33)/t13-,18?,19?/m1/s1 IVYMHMMQRKFONZ-XYJCDUHRSA-N 320037 3-{[3- fluoropiperidin- 4-yl]oxy}-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide, as a mixture of cis isomers::US10174016, Example 204::US10202369, Example 204::US10472354, Example 204 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320037 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320037&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397537 384223313 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625696 C[C@@H](NC(=O)c1cc(O[C@@H]2CCCNC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H24F3N5O2S/c1-13-9-28-21(34-13)16-6-15(7-19(8-16)33-18-4-3-5-27-12-18)20(32)31-14(2)17-10-29-22(30-11-17)23(24,25)26/h6-11,14,18,27H,3-5,12H2,1-2H3,(H,31,32)/t14-,18-/m1/s1 YIMSHVDFMHXVTO-RDTXWAMCSA-N 320253 3-(5-methyl-1,3-thiazol-2-yl)-5-(piperidin-3-yloxy)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 205 P2X purinoceptor 3 Homo sapiens 4.00 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320253 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320253&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 138374923 384223525 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625698 C[C@@H](NC(=O)c1cc(O[C@H]2CCCNC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H24F3N5O2S/c1-13-9-28-21(34-13)16-6-15(7-19(8-16)33-18-4-3-5-27-12-18)20(32)31-14(2)17-10-29-22(30-11-17)23(24,25)26/h6-11,14,18,27H,3-5,12H2,1-2H3,(H,31,32)/t14-,18+/m1/s1 YIMSHVDFMHXVTO-KDOFPFPSSA-N 320039 US10174016, Example 206 P2X purinoceptor 3 Homo sapiens 31.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320039 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320039&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 138374902 384223315 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625700 C[C@@H](NC(=O)c1cc(O[C@@H]2CCNC(C2)C(F)(F)F)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H23F6N5O2S/c1-12-9-32-21(38-12)15-5-14(6-18(7-15)37-17-3-4-31-19(8-17)23(25,26)27)20(36)35-13(2)16-10-33-22(34-11-16)24(28,29)30/h5-7,9-11,13,17,19,31H,3-4,8H2,1-2H3,(H,35,36)/t13-,17-,19?/m1/s1 RLIMWYRKEDYMPQ-BZSPAODLSA-N 320040 3-(5-methyl-1,3-thiazol-2-yl)-5-{[2-(trifluoromethyl)piperidin-4-yl]oxy}-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 207 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320040 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320040&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 138374903 384223316 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625702 C[C@@H](NC(=O)c1cc(O[C@H]2CCNC(C2)C(F)(F)F)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H23F6N5O2S/c1-12-9-32-21(38-12)15-5-14(6-18(7-15)37-17-3-4-31-19(8-17)23(25,26)27)20(36)35-13(2)16-10-33-22(34-11-16)24(28,29)30/h5-7,9-11,13,17,19,31H,3-4,8H2,1-2H3,(H,35,36)/t13-,17+,19?/m1/s1 RLIMWYRKEDYMPQ-XHNGYCAMSA-N 320041 US10174016, Example 208 P2X purinoceptor 3 Homo sapiens 2.00 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320041 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320041&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 138374904 384223317 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625704 C[C@@H](NC(=O)c1cc(OC2CC3CC2CN3C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C25H26F3N5O2S/c1-13-9-29-23(36-13)16-4-15(6-20(7-16)35-21-8-19-5-17(21)12-33(19)3)22(34)32-14(2)18-10-30-24(31-11-18)25(26,27)28/h4,6-7,9-11,14,17,19,21H,5,8,12H2,1-3H3,(H,32,34)/t14-,17?,19?,21?/m1/s1 BQHHMEMNTIGDMM-LXOQGKBISA-N 320042 3-{[2-methyl-2-azabicyclo[2.2.1]hept-5-yl]oxy}-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 209::US10202369, Example 209::US10472354, Example 209 P2X purinoceptor 3 Homo sapiens 30.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320042 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320042&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397807 384223318 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625706 C[C@@H](NC(=O)c1cc(OC2CCN(C)CC2)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F InChI=1S/C24H26F3N5O2S/c1-14-13-28-23(35-14)17-10-16(11-19(12-17)34-18-6-8-32(3)9-7-18)22(33)29-15(2)20-4-5-21(31-30-20)24(25,26)27/h4-5,10-13,15,18H,6-9H2,1-3H3,(H,29,33)/t15-/m1/s1 HKVPHDDZBSOGJS-OAHLLOKOSA-N 320043 3-[(1- methylpiperidin- 4-yl)oxy]-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl} benzamide::US10174016, Example 210::US10202369, Example 210::US10472354, Example 210 P2X purinoceptor 3 Homo sapiens 12.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320043 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320043&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397346 384223319 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625708 C[C@@H](NC(=O)c1cc(OC2CN(C)C2)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F InChI=1S/C22H22F3N5O2S/c1-12-9-26-21(33-12)15-6-14(7-16(8-15)32-17-10-30(3)11-17)20(31)27-13(2)18-4-5-19(29-28-18)22(23,24)25/h4-9,13,17H,10-11H2,1-3H3,(H,27,31)/t13-/m1/s1 IRYKBWGBPIOTOU-CYBMUJFWSA-N 320044 3-[(1- methylazetidin- 3-yl)oxy]-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl} benzamide::US10174016, Example 211::US10202369, Example 211::US10472354, Example 211 P2X purinoceptor 3 Homo sapiens 395 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320044 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320044&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397301 384223320 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625710 C[C@@H](NC(=O)c1cc(OC2CCN(C)CC2F)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H25F4N5O2S/c1-13-9-29-22(36-13)16-6-15(7-18(8-16)35-20-4-5-33(3)12-19(20)25)21(34)32-14(2)17-10-30-23(31-11-17)24(26,27)28/h6-11,14,19-20H,4-5,12H2,1-3H3,(H,32,34)/t14-,19?,20?/m1/s1 XFFHESNTQMKRAI-WPUWVODUSA-N 320045 3-[(3-fluoro-1- methylpiperidin-4- yl)oxy]-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide, as a single unknown isomer::US10174016, Example 212::US10202369, Example 212::US10472354, Example 212 P2X purinoceptor 3 Homo sapiens 4.00 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320045 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320045&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397317 384223321 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625712 C[C@@H](NC(=O)c1cc(OCC2(CC2)N(C)C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H26F3N5O2S/c1-14-10-28-21(35-14)17-7-16(8-19(9-17)34-13-23(5-6-23)32(3)4)20(33)31-15(2)18-11-29-22(30-12-18)24(25,26)27/h7-12,15H,5-6,13H2,1-4H3,(H,31,33)/t15-/m1/s1 GWFQILAPUSJPLG-OAHLLOKOSA-N 320046 3-{[1- (dimethylamino) cyclopropyl] methoxy}- 5-(5-methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 213::US10202369, Example 213::US10472354, Example 213 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320046 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320046&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397636 384223322 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625714 C[C@@H](NC(=O)c1cc(OC2CC3(C2)CN(C)C3)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C25H26F3N5O2S/c1-14-9-29-22(36-14)17-4-16(5-19(6-17)35-20-7-24(8-20)12-33(3)13-24)21(34)32-15(2)18-10-30-23(31-11-18)25(26,27)28/h4-6,9-11,15,20H,7-8,12-13H2,1-3H3,(H,32,34)/t15-/m1/s1 HKONVGJPBICXCZ-OAHLLOKOSA-N 320047 3-[(2-methyl-2- azaspiro [3.3]hept- 6-yl)oxy]-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 214::US10202369, Example 214::US10472354, Example 214 P2X purinoceptor 3 Homo sapiens 47.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320047 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320047&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397792 384223323 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625716 C[C@@H](NC(=O)c1cc(OC2CCN(C)CC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)F InChI=1S/C24H27F2N5O2S/c1-14-11-29-24(34-14)17-8-16(9-20(10-17)33-19-4-6-31(3)7-5-19)23(32)30-15(2)18-12-27-22(21(25)26)28-13-18/h8-13,15,19,21H,4-7H2,1-3H3,(H,30,32)/t15-/m1/s1 XUPWDJXPNRZNKL-OAHLLOKOSA-N 320048 N-{[(1R)-1-[2- (difluoromethyl) pyrimidin-5- yl]ethyl}-3-[(1- methylpiperidin- 4-yl)oxy]-5-(5- methyl-1,3- thiazol-2- yl)benzamide::US10174016, Example 215::US10202369, Example 215 P2X purinoceptor 3 Homo sapiens 16.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320048 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320048&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397133 384223324 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625718 C[C@@H](NC(=O)c1cc(O[C@@H]2C[C@@H]3CC[C@H](C2)N3C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C26H28F3N5O2S/c1-14-11-30-24(37-14)17-6-16(7-21(8-17)36-22-9-19-4-5-20(10-22)34(19)3)23(35)33-15(2)18-12-31-25(32-13-18)26(27,28)29/h6-8,11-13,15,19-20,22H,4-5,9-10H2,1-3H3,(H,33,35)/t15-,19-,20+,22+/m1/s1 BLUSEIUVKSVVTE-DZUANBCISA-N 320049 3-{[(3-endo)-8- methyl-8- azabicyclo[3.2.1] oct-3-yl]oxy}-5- (5-methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 216::US10202369, Example 216::US10472354, Example 216 P2X purinoceptor 3 Homo sapiens 14.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320049 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320049&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397314 384223325 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625720 C[C@@H](NC(=O)c1cc(O[C@H]2C[C@@H]3CC[C@H](C2)N3C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C26H28F3N5O2S/c1-14-11-30-24(37-14)17-6-16(7-21(8-17)36-22-9-19-4-5-20(10-22)34(19)3)23(35)33-15(2)18-12-31-25(32-13-18)26(27,28)29/h6-8,11-13,15,19-20,22H,4-5,9-10H2,1-3H3,(H,33,35)/t15-,19-,20+,22-/m1/s1 BLUSEIUVKSVVTE-BWKKGPAXSA-N 320050 3-{[(3-exo)-8- methyl-8- azabicyclo[3.2.1] oct-3-yl]oxy}- 5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 217::US10202369, Example 217::US10472354, Example 217 P2X purinoceptor 3 Homo sapiens 25.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320050 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320050&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397314 384223326 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625722 C[C@@H](NC(=O)c1cc(O[C@@H]2CC[C@H]3[C@H]2OCCN3C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C26H28F3N5O3S/c1-14-11-30-24(38-14)17-8-16(23(35)33-15(2)18-12-31-25(32-13-18)26(27,28)29)9-19(10-17)37-21-5-4-20-22(21)36-7-6-34(20)3/h8-13,15,20-22H,4-7H2,1-3H3,(H,33,35)/t15-,20+,21-,22-/m1/s1 FEZSJTOXTJNSGQ-WWGKXEARSA-N 320051 3-{[(4aS,7R, 7aR)-4- methyloctahydro- cyclopenta [b][1,4] oxazin-7-yl] oxy}-5- (5-methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 218::US10202369, Example 218::US10472354, Example 218 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320051 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320051&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397834 384223327 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625724 C[C@@H](NC(=O)c1cc(O[C@H]2CC[C@H]3[C@H]2OCCN3C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C26H28F3N5O3S/c1-14-11-30-24(38-14)17-8-16(23(35)33-15(2)18-12-31-25(32-13-18)26(27,28)29)9-19(10-17)37-21-5-4-20-22(21)36-7-6-34(20)3/h8-13,15,20-22H,4-7H2,1-3H3,(H,33,35)/t15-,20+,21+,22-/m1/s1 FEZSJTOXTJNSGQ-NSEXGNSCSA-N 320052 3-{[(4aS,7S, 7aR)-4- methylocta- hydro- cyclopenta[b] [1,4]oxazin- 7-yl]oxy}-5- (5-methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 219::US10202369, Example 219::US10472354, Example 219 P2X purinoceptor 3 Homo sapiens 2.00 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320052 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320052&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397597 384223328 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625726 C[C@@H](NC(=O)c1cc(O[C@@H]2CCCN(C)C2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H26F3N5O2S/c1-14-10-28-22(35-14)17-7-16(8-20(9-17)34-19-5-4-6-32(3)13-19)21(33)31-15(2)18-11-29-23(30-12-18)24(25,26)27/h7-12,15,19H,4-6,13H2,1-3H3,(H,31,33)/t15-,19-/m1/s1 DNVWWBHMIGZIMX-DNVCBOLYSA-N 319991 3-{[(3R)-1- methylpiperidin-3- yl]oxy}-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 158::US10174016, Example 220::US10202369, Example 158::US10472354, Example 158 P2X purinoceptor 3 Homo sapiens 62.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319991 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319991&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397414 384223271 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625728 C[C@@H](NC(=O)c1cc(O[C@H]2CCCN(C)C2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H26F3N5O2S/c1-14-10-28-22(35-14)17-7-16(8-20(9-17)34-19-5-4-6-32(3)13-19)21(33)31-15(2)18-11-29-23(30-12-18)24(25,26)27/h7-12,15,19H,4-6,13H2,1-3H3,(H,31,33)/t15-,19+/m1/s1 DNVWWBHMIGZIMX-BEFAXECRSA-N 319988 3-{[(3S)-1- methylpiperidin-3- yl]oxy}-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 155::US10174016, Example 221::US10202369, Example 155::US10472354, Example 155 P2X purinoceptor 3 Homo sapiens 26.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319988 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319988&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397794 384223268 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625730 C[C@@H](NC(=O)c1cc(O[C@@H]2CCN(C)C(C2)C(F)(F)F)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C25H25F6N5O2S/c1-13-10-32-22(39-13)16-6-15(21(37)35-14(2)17-11-33-23(34-12-17)25(29,30)31)7-19(8-16)38-18-4-5-36(3)20(9-18)24(26,27)28/h6-8,10-12,14,18,20H,4-5,9H2,1-3H3,(H,35,37)/t14-,18-,20?/m1/s1 ALJCLRFXPKVCLC-GNTSEGDPSA-N 320055 3-(5-methyl-1,3-thiazol-2-yl)-5-{[1-methyl-2-(trifluoromethyl)piperidin-4-yl]oxy}-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 222 P2X purinoceptor 3 Homo sapiens 4.00 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320055 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320055&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 138374905 384223329 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625732 C[C@@H](NC(=O)c1cc(O[C@H]2CCN(C)C(C2)C(F)(F)F)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C25H25F6N5O2S/c1-13-10-32-22(39-13)16-6-15(21(37)35-14(2)17-11-33-23(34-12-17)25(29,30)31)7-19(8-16)38-18-4-5-36(3)20(9-18)24(26,27)28/h6-8,10-12,14,18,20H,4-5,9H2,1-3H3,(H,35,37)/t14-,18+,20?/m1/s1 ALJCLRFXPKVCLC-KJOMBKDJSA-N 320056 US10174016, Example 223 P2X purinoceptor 3 Homo sapiens 3.00 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320056 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320056&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 138374906 384223330 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625734 CC(C)N1CCC(CC1)Oc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1ccc(nn1)C(F)(F)F InChI=1S/C26H30F3N5O2S/c1-15(2)34-9-7-20(8-10-34)36-21-12-18(11-19(13-21)25-30-14-16(3)37-25)24(35)31-17(4)22-5-6-23(33-32-22)26(27,28)29/h5-6,11-15,17,20H,7-10H2,1-4H3,(H,31,35)/t17-/m1/s1 KRNISEGUXIGIEE-QGZVFWFLSA-N 320057 3-(5-Methyl-1,3-thiazol-2-yl)-5-{[1-(propan-2-yl)piperidin-4-yl]oxy}-N-{(1R)-1-[6-(trifluoromethyl)pyridazin-3-yl]ethyl}benzamide::US10174016, Example 224::US10202369, Example 224::US10472354, Example 224 P2X purinoceptor 3 Homo sapiens 9.00 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320057 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320057&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397429 384223331 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625736 CC(C)N1CC[C@@H](C1)Oc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C25H28F3N5O2S/c1-14(2)33-6-5-20(13-33)35-21-8-17(7-18(9-21)23-29-10-15(3)36-23)22(34)32-16(4)19-11-30-24(31-12-19)25(26,27)28/h7-12,14,16,20H,5-6,13H2,1-4H3,(H,32,34)/t16-,20+/m1/s1 AIBFTYSUMUVEOU-UZLBHIALSA-N 320058 3-(5-methyl- 1,3-thiazol- 2-yl)-5- {[(3S)-1- (propan-2- yl)pyrrolidin- 3-yl]oxy}-N- {(1R)-1- [2-(trifluoro- methyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 225::US10202369, Example 225::US10472354, Example 225 P2X purinoceptor 3 Homo sapiens 16.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320058 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320058&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397786 384223332 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625738 COC(=O)N1CCC(CC1)Oc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C25H26F3N5O4S/c1-14-11-29-22(38-14)17-8-16(9-20(10-17)37-19-4-6-33(7-5-19)24(35)36-3)21(34)32-15(2)18-12-30-23(31-13-18)25(26,27)28/h8-13,15,19H,4-7H2,1-3H3,(H,32,34)/t15-/m1/s1 XKGQQPBORAHPPR-OAHLLOKOSA-N 320059 Methyl 4-[3-(5-methyl-1,3-thiazol-2-yl)-5-({(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}carbamoyl)phenoxy]piperidine-1-carboxylate::US10174016, Example 226::US10202369, Example 226::US10472354, Example 226 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320059 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320059&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397135 384223333 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625740 CCOC(=O)N1CCC(CC1)Oc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C26H28F3N5O4S/c1-4-37-25(36)34-7-5-20(6-8-34)38-21-10-17(9-18(11-21)23-30-12-15(2)39-23)22(35)33-16(3)19-13-31-24(32-14-19)26(27,28)29/h9-14,16,20H,4-8H2,1-3H3,(H,33,35)/t16-/m1/s1 VLNWCOYPKWPZPZ-MRXNPFEDSA-N 320060 Ethyl 4-[3-(5-methyl-1,3-thiazol-2-yl)-5-({(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}carbamoyl)phenoxy]piperidine-1-carboxylate::US10174016, Example 227::US10202369, Example 227::US10472354, Example 227 P2X purinoceptor 3 Homo sapiens 13.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320060 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320060&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397225 384223334 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625742 CCOC(=O)N1CC[C@@H](C1)Oc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C25H26F3N5O4S/c1-4-36-24(35)33-6-5-19(13-33)37-20-8-16(7-17(9-20)22-29-10-14(2)38-22)21(34)32-15(3)18-11-30-23(31-12-18)25(26,27)28/h7-12,15,19H,4-6,13H2,1-3H3,(H,32,34)/t15-,19+/m1/s1 ZKABVOKJBCLEBM-BEFAXECRSA-N 320061 Ethyl (3S)-3-[3-(5-methyl-1,3-thiazol-2-yl)-5-({(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}carbamoyl)phenoxy]pyrrolidine-1-carboxylate::US10174016, Example 228::US10202369, Example 228::US10472354, Example 228 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320061 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320061&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134338446 384223335 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625744 CC(C)N1CC(C1)Oc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C24H26F3N5O2S/c1-13(2)32-11-20(12-32)34-19-6-16(5-17(7-19)22-28-8-14(3)35-22)21(33)31-15(4)18-9-29-23(30-10-18)24(25,26)27/h5-10,13,15,20H,11-12H2,1-4H3,(H,31,33)/t15-/m1/s1 ZGCTZBYNIOVVEC-OAHLLOKOSA-N 320062 3-(5-Methyl-1,3-thiazol-2-yl)-5-{[1-(propan-2-yl)azetidin-3-yl]oxy}-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 229::US10202369, Example 229::US10472354, Example 229 P2X purinoceptor 3 Homo sapiens 44.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320062 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320062&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397633 384223336 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625746 CC(O)[C@H](C)Oc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1ccc(nn1)C(F)(F)F InChI=1S/C22H23F3N4O3S/c1-11-10-26-21(33-11)16-7-15(8-17(9-16)32-14(4)13(3)30)20(31)27-12(2)18-5-6-19(29-28-18)22(23,24)25/h5-10,12-14,30H,1-4H3,(H,27,31)/t12-,13?,14+/m1/s1 LMHZXBDHIYABCN-YIOYIWSBSA-N 320063 3-[(−3-hydroxybutan-2-yl)oxy]-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[6-(trifluoromethyl)pyridazin-3-yl]ethyl}benzamide::US10174016, Example 230 P2X purinoceptor 3 Homo sapiens 2.00 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320063 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320063&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 138374907 384223337 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625748 CC(O)[C@@H](C)Oc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1ccc(nn1)C(F)(F)F InChI=1S/C22H23F3N4O3S/c1-11-10-26-21(33-11)16-7-15(8-17(9-16)32-14(4)13(3)30)20(31)27-12(2)18-5-6-19(29-28-18)22(23,24)25/h5-10,12-14,30H,1-4H3,(H,27,31)/t12-,13?,14-/m1/s1 LMHZXBDHIYABCN-WYAMFQBQSA-N 320064 US10174016, Example 231 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320064 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320064&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 138374908 384223338 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625750 C[C@@H](NC(=O)c1cc(OC2CCS(=O)(=O)CC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H23F3N4O4S2/c1-13-10-27-21(35-13)16-7-15(8-19(9-16)34-18-3-5-36(32,33)6-4-18)20(31)30-14(2)17-11-28-22(29-12-17)23(24,25)26/h7-12,14,18H,3-6H2,1-2H3,(H,30,31)/t14-/m1/s1 JTWSIDWRGZSZAA-CQSZACIVSA-N 320065 3-[(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)oxy]-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 232::US10202369, Example 232::US10472354, Example 232 P2X purinoceptor 3 Homo sapiens 13.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320065 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320065&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397851 384223339 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625752 C[C@@H](NC(=O)c1cc(OC2CCS(=O)(=O)CC2)cc(c1)-c1ncc(C)s1)c1ccc(nc1)C(F)(F)F InChI=1S/C24H24F3N3O4S2/c1-14-12-29-23(35-14)18-9-17(10-20(11-18)34-19-5-7-36(32,33)8-6-19)22(31)30-15(2)16-3-4-21(28-13-16)24(25,26)27/h3-4,9-13,15,19H,5-8H2,1-2H3,(H,30,31)/t15-/m1/s1 BRFDVYQZWOBZCT-OAHLLOKOSA-N 320066 3-[(1,1- dioxidotetrahydro- 2H-thiopyran-4- yl)oxy]-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[6- (trifluoromethyl) pyridin-3-yl]ethyl} benzamide::US10174016, Example 233::US10202369, Example 233::US10472354, Example 233 P2X purinoceptor 3 Homo sapiens 16.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320066 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320066&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397139 384223340 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625754 CCc1cnc(s1)-c1cc(OC2CCOCC2)cc(c1)C(=O)N[C@H](C)c1cnc(C)cn1 InChI=1S/C24H28N4O3S/c1-4-21-13-27-24(32-21)18-9-17(10-20(11-18)31-19-5-7-30-8-6-19)23(29)28-16(3)22-14-25-15(2)12-26-22/h9-14,16,19H,4-8H2,1-3H3,(H,28,29)/t16-/m1/s1 DYONOLZVTXITOM-MRXNPFEDSA-N 320067 3-(5-ethyl-1,3- thiazol-2-yl)-N- [(1R)-1-(5- methylpyrazin-2- yl)ethyl]-5- (tetrahydro-2H- pyran-4- yloxy)benzamide::US10174016, Example 234::US10202369, Example 234::US10472354, Example 234 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320067 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320067&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397540 384223341 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625756 CCc1cnc(s1)-c1cc(OC2CCOCC2)cc(c1)C(=O)NCc1ccc(C)nn1 InChI=1S/C23H26N4O3S/c1-3-21-14-25-23(31-21)17-10-16(11-20(12-17)30-19-6-8-29-9-7-19)22(28)24-13-18-5-4-15(2)26-27-18/h4-5,10-12,14,19H,3,6-9,13H2,1-2H3,(H,24,28) BZFPOECMUNEZDH-UHFFFAOYSA-N 320068 3-(5-ethyl-1,3- thiazol-2-yl)-N-[(6- methylpyridazin-3- yl)methyl]-5- (tetrahydro-2H- pyran-4- yloxy)benzamide::US10174016, Example 235::US10202369, Example 235::US10472354, Example 235 P2X purinoceptor 3 Homo sapiens 18.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320068 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320068&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397197 384223342 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625758 C[C@@H](NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(s1)C1CCC1)c1cnc(C)cn1 InChI=1S/C26H30N4O3S/c1-16-13-28-23(14-27-16)17(2)30-25(31)19-10-20(26-29-15-24(34-26)18-4-3-5-18)12-22(11-19)33-21-6-8-32-9-7-21/h10-15,17-18,21H,3-9H2,1-2H3,(H,30,31)/t17-/m1/s1 QOZNFPLCSPWJRX-QGZVFWFLSA-N 320069 3-(5-cyclobutyl- 1,3-thiazol-2-yl)- N-[(1R)-1-(5- methylpyrazin-2- yl)ethyl]-5- (tetrahydro-2H- pyran-4- yloxy)benzamide::US10174016, Example 236::US10202369, Example 236::US10472354, Example 236 P2X purinoceptor 3 Homo sapiens 76.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320069 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320069&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397529 384223343 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625760 Cc1ccc(CNC(=O)c2cc(OC3CCOCC3)cc(c2)-c2ncc(s2)C2CCC2)nn1 InChI=1S/C25H28N4O3S/c1-16-5-6-20(29-28-16)14-26-24(30)18-11-19(25-27-15-23(33-25)17-3-2-4-17)13-22(12-18)32-21-7-9-31-10-8-21/h5-6,11-13,15,17,21H,2-4,7-10,14H2,1H3,(H,26,30) KYDTWNODFNIYNY-UHFFFAOYSA-N 320070 3-(5-cyclobutyl- 1,3-thiazol-2-yl)- N-[(6- methylpyridazin-3- yl)methyl]-5- (tetrahydro-2H- pyran-4- yloxy)benzamide::US10174016, Example 237::US10202369, Example 237::US10472354, Example 237 P2X purinoceptor 3 Homo sapiens 177 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320070 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320070&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397323 384223344 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625762 C[C@@H](NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(s1)C1CCC1)c1cnc(nc1)C(F)(F)F InChI=1S/C26H27F3N4O3S/c1-15(19-12-31-25(32-13-19)26(27,28)29)33-23(34)17-9-18(24-30-14-22(37-24)16-3-2-4-16)11-21(10-17)36-20-5-7-35-8-6-20/h9-16,20H,2-8H2,1H3,(H,33,34)/t15-/m1/s1 KTFAMKPHNDUKLL-OAHLLOKOSA-N 320071 3-(5-cyclobutyl- 1,3-thiazol-2-yl)-5- (tetrahydro-2H- pyran-4-yloxy)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 238::US10202369, Example 238::US10472354, Example 238 P2X purinoceptor 3 Homo sapiens 38.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320071 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320071&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397176 384223345 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625764 C[C@H](NC(=O)c1cc(OC[C@H]2CCOC2)cc(c1)-c1ncc(s1)C1CCC1)c1cnc(nc1)C(F)(F)F InChI=1S/C26H27F3N4O3S/c1-15(20-10-31-25(32-11-20)26(27,28)29)33-23(34)18-7-19(24-30-12-22(37-24)17-3-2-4-17)9-21(8-18)36-14-16-5-6-35-13-16/h7-12,15-17H,2-6,13-14H2,1H3,(H,33,34)/t15-,16-/m0/s1 JWRPHAGJMIAQMD-HOTGVXAUSA-N 320072 3-(5-cyclobutyl- 1,3-thiazol-2-yl)-5- [(3S)- tetrahydrofuran-3- ylmethoxy]-N- {(1S)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 239::US10202369, Example 239::US10472354, Example 239 P2X purinoceptor 3 Homo sapiens 1420 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320072 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320072&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397719 384223346 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625766 CCc1cnc(s1)-c1cc(O[C@@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1ccc(C)nn1 InChI=1S/C23H26N4O3S/c1-4-20-12-24-23(31-20)17-9-16(10-19(11-17)30-18-7-8-29-13-18)22(28)25-15(3)21-6-5-14(2)26-27-21/h5-6,9-12,15,18H,4,7-8,13H2,1-3H3,(H,25,28)/t15-,18-/m1/s1 OXXUGGORGDKECE-CRAIPNDOSA-N 320073 3-(5-ethyl-1,3- thiazol-2-yl)-N- [(1R)-1-(6- methylpyridazin-3- yl)ethyl]-5-[(3R)- tetrahydrofuran-3- yloxy]benzamide::US10174016, Example 240::US10202369, Example 249::US10472354, Example 240 P2X purinoceptor 3 Homo sapiens 12.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320073 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320073&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397178 384223347 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625768 CCc1cnc(s1)-c1cc(O[C@@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1cnc(C)cn1 InChI=1S/C23H26N4O3S/c1-4-20-11-26-23(31-20)17-7-16(8-19(9-17)30-18-5-6-29-13-18)22(28)27-15(3)21-12-24-14(2)10-25-21/h7-12,15,18H,4-6,13H2,1-3H3,(H,27,28)/t15-,18-/m1/s1 GGGFDTSSCKHCGY-CRAIPNDOSA-N 320074 3-(5-ethyl-1,3- thiazol-2-yl)-N- [(1R)-1-(5- methylpyrazin-2- yl)ethyl]-5-[(3R)- tetrahydrofuran-3- yloxy]benzamide::US10174016, Example 241::US10202369, Example 241::US10472354, Example 241 P2X purinoceptor 3 Homo sapiens 12.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320074 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320074&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397675 384223348 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625770 CCc1cnc(s1)-c1cc(O[C@@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C23H23F3N4O3S/c1-3-19-11-27-21(34-19)15-6-14(7-18(8-15)33-17-4-5-32-12-17)20(31)30-13(2)16-9-28-22(29-10-16)23(24,25)26/h6-11,13,17H,3-5,12H2,1-2H3,(H,30,31)/t13-,17-/m1/s1 CPHCWMUXIASQAI-CXAGYDPISA-N 320075 3-(5-ethyl-1,3- thiazol-2-yl)-5- [(3R)- tetrahydrofuran-3- yloxy]-N-{(1R)-1- [2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 242::US10202369, Example 242::US10472354, Example 242 P2X purinoceptor 3 Homo sapiens 2.00 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320075 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320075&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397732 384223349 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625772 C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(s1)C1CCC1)c1ccc(C)nn1 InChI=1S/C25H28N4O3S/c1-15-6-7-22(29-28-15)16(2)27-24(30)18-10-19(12-21(11-18)32-20-8-9-31-14-20)25-26-13-23(33-25)17-4-3-5-17/h6-7,10-13,16-17,20H,3-5,8-9,14H2,1-2H3,(H,27,30)/t16-,20-/m1/s1 GBDWWYIZWHGLEN-OXQOHEQNSA-N 320076 3-(5-cyclobutyl- 1,3-thiazol-2-yl)- N-[(1R)-1-(6- methylpyridazin-3- yl)ethyl]-5-[(3R)- tetrahydrofuran-3- yloxy]benzamide::US10174016, Example 243::US10202369, Example 243::US10472354, Example 243 P2X purinoceptor 3 Homo sapiens 117 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320076 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320076&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397824 384223350 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625774 C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(s1)C1CCC1)c1cnc(C)cn1 InChI=1S/C25H28N4O3S/c1-15-11-27-22(12-26-15)16(2)29-24(30)18-8-19(10-21(9-18)32-20-6-7-31-14-20)25-28-13-23(33-25)17-4-3-5-17/h8-13,16-17,20H,3-7,14H2,1-2H3,(H,29,30)/t16-,20-/m1/s1 FVGXVLFIHFQXPP-OXQOHEQNSA-N 320077 3-(5-cyclobutyl- 1,3-thiazol-2-yl)- N-[(1R)-1-(5- methylpyrazin-2- yl)ethyl]-5-[(3R)- tetrahydrofuran-3- yloxy]benzamide::US10174016, Example 244::US10202369, Example 244::US10472354, Example 244 P2X purinoceptor 3 Homo sapiens 75.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320077 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320077&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397416 384223351 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625776 C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(s1)C1CCC1)c1cnc(nc1)C(F)(F)F InChI=1S/C25H25F3N4O3S/c1-14(18-10-30-24(31-11-18)25(26,27)28)32-22(33)16-7-17(9-20(8-16)35-19-5-6-34-13-19)23-29-12-21(36-23)15-3-2-4-15/h7-12,14-15,19H,2-6,13H2,1H3,(H,32,33)/t14-,19-/m1/s1 IDGMWIXZIVCDCF-AUUYWEPGSA-N 320078 3-(5-cyclobutyl- 1,3-thiazol-2-yl)-5- [(3R)- tetrahydrofuran-3- yloxy]-N-{(1R)-1- [2-(trifluoromethyl) pyrimidin-5-yl] ethyl}benzamide::US10174016, Example 245::US10202369, Example 245::US10472354, Example 245 P2X purinoceptor 3 Homo sapiens 34.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320078 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320078&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397471 384223352 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625778 CC(C)c1cnc(s1)-c1cc(O[C@@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1ccc(C)nn1 InChI=1S/C24H28N4O3S/c1-14(2)22-12-25-24(32-22)18-9-17(10-20(11-18)31-19-7-8-30-13-19)23(29)26-16(4)21-6-5-15(3)27-28-21/h5-6,9-12,14,16,19H,7-8,13H2,1-4H3,(H,26,29)/t16-,19-/m1/s1 AZADLHFQZQVHQV-VQIMIIECSA-N 320079 N-[(1R)-1-(6- methylpyridazin-3- yl)ethyl]-3-[5- (propan-2-yl)-1,3- thiazol-2-yl]-5- [(3R)- tetrahydrofuran-3- yloxy]benzamide::US10174016, Example 246::US10202369, Example 246::US10472354, Example 246 P2X purinoceptor 3 Homo sapiens 266 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320079 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320079&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397745 384223353 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625780 CC(C)c1cnc(s1)-c1cc(O[C@@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1cnc(C)cn1 InChI=1S/C24H28N4O3S/c1-14(2)22-12-27-24(32-22)18-7-17(8-20(9-18)31-19-5-6-30-13-19)23(29)28-16(4)21-11-25-15(3)10-26-21/h7-12,14,16,19H,5-6,13H2,1-4H3,(H,28,29)/t16-,19-/m1/s1 ULUQVVVXKLITBV-VQIMIIECSA-N 320080 N-[(1R)-1-(5- methylpyrazin-2- yl)ethyl]-3-[5- (propan-2-yl)-1,3- thiazol-2-yl]-5- [(3R)- tetrahydrofuran-3- yloxy]benzamide::US10174016, Example 247::US10202369, Example 247::US10472354, Example 247 P2X purinoceptor 3 Homo sapiens 205 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320080 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320080&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397213 384223354 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625782 CC(C)c1cnc(s1)-c1cc(O[C@@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C24H25F3N4O3S/c1-13(2)20-11-28-22(35-20)16-6-15(7-19(8-16)34-18-4-5-33-12-18)21(32)31-14(3)17-9-29-23(30-10-17)24(25,26)27/h6-11,13-14,18H,4-5,12H2,1-3H3,(H,31,32)/t14-,18-/m1/s1 COCLYUAEQYUAPW-RDTXWAMCSA-N 320081 3-[5-(propan-2-yl)- 1,3-thiazol-2-yl]-5- [(3R)- tetrahydrofuran-3- yloxy]-N-{(1R)-1- [2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 248::US10202369, Example 248::US10472354, Example 248 P2X purinoceptor 3 Homo sapiens 44.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320081 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320081&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397577 384223355 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625784 CCc1cnc(s1)-c1cc(O[C@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1ccc(C)nn1 InChI=1S/C23H26N4O3S/c1-4-20-12-24-23(31-20)17-9-16(10-19(11-17)30-18-7-8-29-13-18)22(28)25-15(3)21-6-5-14(2)26-27-21/h5-6,9-12,15,18H,4,7-8,13H2,1-3H3,(H,25,28)/t15-,18+/m1/s1 OXXUGGORGDKECE-QAPCUYQASA-N 320082 3-(5-ethyl-1,3- thiazol-2-yl)-N- [(1R)-1-(6- methylpyridazin-3- yl)ethyl]-5-[(3S)- tetrahydrofuran-3- yloxy]benzamide::US10174016, Example 249::US10472354, Example 249 P2X purinoceptor 3 Homo sapiens 11.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320082 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320082&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397606 384223356 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625786 CCc1cnc(s1)-c1cc(O[C@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1cnc(C)cn1 InChI=1S/C23H26N4O3S/c1-4-20-11-26-23(31-20)17-7-16(8-19(9-17)30-18-5-6-29-13-18)22(28)27-15(3)21-12-24-14(2)10-25-21/h7-12,15,18H,4-6,13H2,1-3H3,(H,27,28)/t15-,18+/m1/s1 GGGFDTSSCKHCGY-QAPCUYQASA-N 320083 3-(5-ethyl-1,3- thiazol-2-yl)-N- [(1R)-1-(5- methylpyrazin-2- yl)ethyl]-5-[(3S)- tetrahydrofuran-3- yloxy]benzamide::US10174016, Example 250::US10202369, Example 250::US10472354, Example 250 P2X purinoceptor 3 Homo sapiens 15.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320083 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320083&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397653 384223357 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625788 CCc1cnc(s1)-c1cc(O[C@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C23H23F3N4O3S/c1-3-19-11-27-21(34-19)15-6-14(7-18(8-15)33-17-4-5-32-12-17)20(31)30-13(2)16-9-28-22(29-10-16)23(24,25)26/h6-11,13,17H,3-5,12H2,1-2H3,(H,30,31)/t13-,17+/m1/s1 CPHCWMUXIASQAI-DYVFJYSZSA-N 320084 3-(5-ethyl-1,3- thiazol-2-yl)-5- [(3S)- tetrahydrofuran-3- yloxy]-N-{(1R)-1- [2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 251::US10202369, Example 251::US10472354, Example 251 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320084 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320084&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397624 384223358 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625790 C[C@@H](NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(s1)C1CCC1)c1ccc(C)nn1 InChI=1S/C25H28N4O3S/c1-15-6-7-22(29-28-15)16(2)27-24(30)18-10-19(12-21(11-18)32-20-8-9-31-14-20)25-26-13-23(33-25)17-4-3-5-17/h6-7,10-13,16-17,20H,3-5,8-9,14H2,1-2H3,(H,27,30)/t16-,20+/m1/s1 GBDWWYIZWHGLEN-UZLBHIALSA-N 320085 3-(5-cyclobutyl- 1,3-thiazol-2-yl)- N-[(1R)-1-(6- methylpyridazin-3- yl)ethyl]-5-[(3S)- tetrahydrofuran-3- yloxy]benzamide::US10174016, Example 252::US10202369, Example 252::US10472354, Example 252 P2X purinoceptor 3 Homo sapiens 75.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320085 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320085&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397825 384223359 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625792 C[C@@H](NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(s1)C1CCC1)c1cnc(C)cn1 InChI=1S/C25H28N4O3S/c1-15-11-27-22(12-26-15)16(2)29-24(30)18-8-19(10-21(9-18)32-20-6-7-31-14-20)25-28-13-23(33-25)17-4-3-5-17/h8-13,16-17,20H,3-7,14H2,1-2H3,(H,29,30)/t16-,20+/m1/s1 FVGXVLFIHFQXPP-UZLBHIALSA-N 320086 3-(5-cyclobutyl- 1,3-thiazol-2-yl)- N-[(1R)-1-(5- methylpyrazin-2- yl)ethyl]-5-[(3S)- tetrahydrofuran-3- yloxy]benzamide::US10174016, Example 253::US10202369, Example 253::US10472354, Example 253 P2X purinoceptor 3 Homo sapiens 99.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320086 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320086&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397513 384223360 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625794 C[C@@H](NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(s1)C1CCC1)c1cnc(nc1)C(F)(F)F InChI=1S/C25H25F3N4O3S/c1-14(18-10-30-24(31-11-18)25(26,27)28)32-22(33)16-7-17(9-20(8-16)35-19-5-6-34-13-19)23-29-12-21(36-23)15-3-2-4-15/h7-12,14-15,19H,2-6,13H2,1H3,(H,32,33)/t14-,19+/m1/s1 IDGMWIXZIVCDCF-KUHUBIRLSA-N 320087 3-(5-cyclobutyl- 1,3-thiazol-2-yl)-5- [(3S)- tetrahydrofuran-3- yloxy]-N-{(1R)-1- [2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 254::US10202369, Example 254::US10472354, Example 254 P2X purinoceptor 3 Homo sapiens 28.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320087 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320087&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397641 384223361 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625796 CC(C)c1cnc(s1)-c1cc(O[C@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1ccc(C)nn1 InChI=1S/C24H28N4O3S/c1-14(2)22-12-25-24(32-22)18-9-17(10-20(11-18)31-19-7-8-30-13-19)23(29)26-16(4)21-6-5-15(3)27-28-21/h5-6,9-12,14,16,19H,7-8,13H2,1-4H3,(H,26,29)/t16-,19+/m1/s1 AZADLHFQZQVHQV-APWZRJJASA-N 320088 N-[(1R)-1-(6- methylpyridazin-3- yl)ethyl]-3-[5- (propan-2-yl)-1,3- thiazol-2-yl]-5- [(3S)- tetrahydrofuran-3- yloxy]benzamide::US10174016, Example 255::US10202369, Example 255::US10472354, Example 255 P2X purinoceptor 3 Homo sapiens 254 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320088 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320088&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397188 384223362 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625798 CC(C)c1cnc(s1)-c1cc(O[C@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1cnc(C)cn1 InChI=1S/C24H28N4O3S/c1-14(2)22-12-27-24(32-22)18-7-17(8-20(9-18)31-19-5-6-30-13-19)23(29)28-16(4)21-11-25-15(3)10-26-21/h7-12,14,16,19H,5-6,13H2,1-4H3,(H,28,29)/t16-,19+/m1/s1 ULUQVVVXKLITBV-APWZRJJASA-N 320089 N-[(1R)-1-(5- methylpyrazin-2- yl)ethyl]-3-[5- (propan-2-yl)-1,3- thiazol-2-yl]-5- [(3S)- tetrahydrofuran-3- yloxy]benzamide::US10174016, Example 256::US10202369, Example 256::US10472354, Example 256 P2X purinoceptor 3 Homo sapiens 136 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320089 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320089&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397239 384223363 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625800 CC(C)c1cnc(s1)-c1cc(O[C@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C24H25F3N4O3S/c1-13(2)20-11-28-22(35-20)16-6-15(7-19(8-16)34-18-4-5-33-12-18)21(32)31-14(3)17-9-29-23(30-10-17)24(25,26)27/h6-11,13-14,18H,4-5,12H2,1-3H3,(H,31,32)/t14-,18+/m1/s1 COCLYUAEQYUAPW-KDOFPFPSSA-N 320090 3-[5-(propan-2-yl)- 1,3-thiazol-2-yl]-5- [(3S)- tetrahydrofuran-3- yloxy]-N-{(1R)-1- [2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 257::US10202369, Example 257::US10472354, Example 257 P2X purinoceptor 3 Homo sapiens 47.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320090 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320090&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397534 384223364 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625802 CCc1cnc(s1)-c1cc(OC[C@@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1ccc(C)nn1 InChI=1S/C24H28N4O3S/c1-4-21-12-25-24(32-21)19-9-18(10-20(11-19)31-14-17-7-8-30-13-17)23(29)26-16(3)22-6-5-15(2)27-28-22/h5-6,9-12,16-17H,4,7-8,13-14H2,1-3H3,(H,26,29)/t16-,17-/m1/s1 CPQUPRVXRIYFHX-IAGOWNOFSA-N 320091 3-(5-ethyl-1,3- thiazol-2-yl)-N- [(1R)-1-(6- methylpyridazin-3- yl)ethyl]-5-[(3R)- tetrahydrofuran-3- ylmethoxy] benzamide::US10174016, Example 258::US10202369, Example 258::US10472354, Example 282 P2X purinoceptor 3 Homo sapiens 4.00 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320091 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320091&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397177 384223365 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625804 CCc1cnc(s1)-c1cc(OC[C@@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1cnc(C)cn1 InChI=1S/C24H28N4O3S/c1-4-21-11-27-24(32-21)19-7-18(8-20(9-19)31-14-17-5-6-30-13-17)23(29)28-16(3)22-12-25-15(2)10-26-22/h7-12,16-17H,4-6,13-14H2,1-3H3,(H,28,29)/t16-,17-/m1/s1 PZFOCXJBZDWRSU-IAGOWNOFSA-N 320092 3-(5-ethyl-1,3- thiazol-2-yl)-N- [(1R)-1-(5- methylpyrazin-2- yl)ethyl]-5-[(3R)- tetrahydrofuran-3- ylmethoxy] benzamide::US10174016, Example 259::US10202369, Example 259::US10472354, Example 283 P2X purinoceptor 3 Homo sapiens 10.00 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320092 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320092&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397564 384223366 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625806 CCc1cnc(s1)-c1cc(OC[C@@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C24H25F3N4O3S/c1-3-20-11-28-22(35-20)17-6-16(7-19(8-17)34-13-15-4-5-33-12-15)21(32)31-14(2)18-9-29-23(30-10-18)24(25,26)27/h6-11,14-15H,3-5,12-13H2,1-2H3,(H,31,32)/t14-,15-/m1/s1 VOKPPDDBRIDGES-HUUCEWRRSA-N 320093 3-(5-ethyl-1,3- thiazol-2-yl)-5- [(3R)- tetrahydrofuran-3- ylmethoxy]-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 260::US10202369, Example 260::US10472354, Example 260 P2X purinoceptor 3 Homo sapiens 2.00 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320093 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320093&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397266 384223367 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625808 C[C@@H](NC(=O)c1cc(OC[C@@H]2CCOC2)cc(c1)-c1ncc(s1)C1CCC1)c1ccc(C)nn1 InChI=1S/C26H30N4O3S/c1-16-6-7-23(30-29-16)17(2)28-25(31)20-10-21(26-27-13-24(34-26)19-4-3-5-19)12-22(11-20)33-15-18-8-9-32-14-18/h6-7,10-13,17-19H,3-5,8-9,14-15H2,1-2H3,(H,28,31)/t17-,18-/m1/s1 KRMAXJMLJAVOGJ-QZTJIDSGSA-N 320094 3-(5-cyclobutyl- 1,3-thiazol-2-yl)- N-[(1R)-1-(6- methylpyridazin-3- yl)ethyl]-5-[(3R)- tetrahydrofuran-3- ylmethoxy] benzamide::US10174016, Example 261::US10202369, Example 261::US10472354, Example 261 P2X purinoceptor 3 Homo sapiens 45.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320094 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320094&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397842 384223368 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625810 C[C@@H](NC(=O)c1cc(OC[C@@H]2CCOC2)cc(c1)-c1ncc(s1)C1CCC1)c1cnc(C)cn1 InChI=1S/C26H30N4O3S/c1-16-11-28-23(12-27-16)17(2)30-25(31)20-8-21(26-29-13-24(34-26)19-4-3-5-19)10-22(9-20)33-15-18-6-7-32-14-18/h8-13,17-19H,3-7,14-15H2,1-2H3,(H,30,31)/t17-,18-/m1/s1 ZBRXLMDGZXDHGV-QZTJIDSGSA-N 320095 3-(5-cyclobutyl- 1,3-thiazol-2-yl)- N-[(1R)-1-(5- methylpyrazin-2- yl)ethyl]-5-[(3R)- tetrahydrofuran-3- ylmethoxy] benzamide::US10174016, Example 262::US10202369, Example 262::US10472354, Example 262 P2X purinoceptor 3 Homo sapiens 85.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320095 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320095&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397383 384223369 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625812 C[C@@H](NC(=O)c1cc(OC[C@@H]2CCOC2)cc(c1)-c1ncc(s1)C1CCC1)c1cnc(nc1)C(F)(F)F InChI=1S/C26H27F3N4O3S/c1-15(20-10-31-25(32-11-20)26(27,28)29)33-23(34)18-7-19(24-30-12-22(37-24)17-3-2-4-17)9-21(8-18)36-14-16-5-6-35-13-16/h7-12,15-17H,2-6,13-14H2,1H3,(H,33,34)/t15-,16-/m1/s1 JWRPHAGJMIAQMD-HZPDHXFCSA-N 320096 3-(5-cyclobutyl- 1,3-thiazol-2-yl)-5- [(3R)- tetrahydrofuran-3- ylmethoxy]-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 263::US10202369, Example 263::US10472354, Example 263 P2X purinoceptor 3 Homo sapiens 33.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320096 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320096&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397122 384223370 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625814 CC(C)c1cnc(s1)-c1cc(OC[C@@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1ccc(C)nn1 InChI=1S/C25H30N4O3S/c1-15(2)23-12-26-25(33-23)20-9-19(10-21(11-20)32-14-18-7-8-31-13-18)24(30)27-17(4)22-6-5-16(3)28-29-22/h5-6,9-12,15,17-18H,7-8,13-14H2,1-4H3,(H,27,30)/t17-,18-/m1/s1 HVLSFPXITWENER-QZTJIDSGSA-N 320097 N-[(1R)-1-(6- methylpyridazin-3- yl)ethyl]-3-[5- (propan-2-yl)-1,3- thiazol-2-yl]-5- [(3R)- tetrahydrofuran-3- ylmethoxy] benzamide::US10174016, Example 264::US10202369, Example 264::US10472354, Example 264 P2X purinoceptor 3 Homo sapiens 81.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320097 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320097&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397620 384223371 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625816 CC(C)c1cnc(s1)-c1cc(OC[C@@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1cnc(C)cn1 InChI=1S/C25H30N4O3S/c1-15(2)23-12-28-25(33-23)20-7-19(8-21(9-20)32-14-18-5-6-31-13-18)24(30)29-17(4)22-11-26-16(3)10-27-22/h7-12,15,17-18H,5-6,13-14H2,1-4H3,(H,29,30)/t17-,18-/m1/s1 MWBSFWZECXCRJX-QZTJIDSGSA-N 320098 N-[(1R)-1-(5- methylpyrazin-2- yl)ethyl]-3-[5- (propan-2-yl)-1,3- thiazol-2-yl]-5- [(3R)- tetrahydrofuran-3- ylmethoxy] benzamide::US10174016, Example 265::US10202369, Example 265::US10472354, Example 265 P2X purinoceptor 3 Homo sapiens 104 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320098 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320098&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397233 384223372 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625818 CC(C)c1cnc(s1)-c1cc(OC[C@@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C25H27F3N4O3S/c1-14(2)21-11-29-23(36-21)18-6-17(7-20(8-18)35-13-16-4-5-34-12-16)22(33)32-15(3)19-9-30-24(31-10-19)25(26,27)28/h6-11,14-16H,4-5,12-13H2,1-3H3,(H,32,33)/t15-,16-/m1/s1 JZRSBKDBMGCFDH-HZPDHXFCSA-N 320099 3-[5-(propan-2-yl)- 1,3-thiazol-2-yl]-5- [(3R)- tetrahydrofuran-3- ylmethoxy]-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 266::US10202369, Example 266::US10472354, Example 266 P2X purinoceptor 3 Homo sapiens 41.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320099 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320099&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397337 384223373 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625820 CCc1cnc(s1)-c1cc(OC[C@H]2CCCO2)cc(c1)C(=O)N[C@H](C)c1ccc(C)nn1 InChI=1S/C24H28N4O3S/c1-4-21-13-25-24(32-21)18-10-17(11-20(12-18)31-14-19-6-5-9-30-19)23(29)26-16(3)22-8-7-15(2)27-28-22/h7-8,10-13,16,19H,4-6,9,14H2,1-3H3,(H,26,29)/t16-,19-/m1/s1 CEYURJDFNAEZIM-VQIMIIECSA-N 320100 3-(5-ethyl-1,3- thiazol-2-yl)-N- [(1R)-1-(6- methylpyridazin-3- yl)ethyl]-5-[(2R)- tetrahydrofuran-2- ylmethoxy] benzamide::US10174016, Example 267::US10202369, Example 276 P2X purinoceptor 3 Homo sapiens 14.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320100 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320100&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397219 384223374 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625822 CCc1cnc(s1)-c1cc(OC[C@H]2CCCO2)cc(c1)C(=O)N[C@H](C)c1cnc(C)cn1 InChI=1S/C24H28N4O3S/c1-4-21-12-27-24(32-21)18-8-17(9-20(10-18)31-14-19-6-5-7-30-19)23(29)28-16(3)22-13-25-15(2)11-26-22/h8-13,16,19H,4-7,14H2,1-3H3,(H,28,29)/t16-,19-/m1/s1 AKBLPSFNNBDTQK-VQIMIIECSA-N 320101 3-(5-ethyl-1,3- thiazol-2-yl)-N- [(1R)-1-(5- methylpyrazin-2- yl)ethyl]-5-[(2R)- tetrahydrofuran-2- ylmethoxy] benzamide::US10174016, Example 268::US10202369, Example 277 P2X purinoceptor 3 Homo sapiens 14.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320101 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320101&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397780 384223375 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625824 CCc1cnc(s1)-c1cc(OC[C@H]2CCCO2)cc(c1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C24H25F3N4O3S/c1-3-20-12-28-22(35-20)16-7-15(8-19(9-16)34-13-18-5-4-6-33-18)21(32)31-14(2)17-10-29-23(30-11-17)24(25,26)27/h7-12,14,18H,3-6,13H2,1-2H3,(H,31,32)/t14-,18-/m1/s1 IDFXYIYQWCENGA-RDTXWAMCSA-N 320102 3-(5-ethyl-1,3- thiazol-2-yl)-5- [(2R)- tetrahydrofuran-2- ylmethoxy]-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 269::US10202369, Example 278 P2X purinoceptor 3 Homo sapiens 2.00 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320102 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320102&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397217 384223376 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625826 C[C@@H](NC(=O)c1cc(OC[C@H]2CCCO2)cc(c1)-c1ncc(s1)C1CCC1)c1ccc(C)nn1 InChI=1S/C26H30N4O3S/c1-16-8-9-23(30-29-16)17(2)28-25(31)19-11-20(26-27-14-24(34-26)18-5-3-6-18)13-22(12-19)33-15-21-7-4-10-32-21/h8-9,11-14,17-18,21H,3-7,10,15H2,1-2H3,(H,28,31)/t17-,21-/m1/s1 NLLVDMMXBRFWGS-DYESRHJHSA-N 320103 3-(5-cyclobutyl- 1,3-thiazol-2-yl)- N-[(1R)-1-(6- methylpyridazin-3- yl)ethyl]-5-[(2R)- tetrahydrofuran-2- ylmethoxy] benzamide::US10174016, Example 270::US10202369, Example 270 P2X purinoceptor 3 Homo sapiens 25.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320103 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320103&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397499 384223377 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625828 C[C@@H](NC(=O)c1cc(OC[C@H]2CCCO2)cc(c1)-c1ncc(s1)C1CCC1)c1cnc(C)cn1 InChI=1S/C26H30N4O3S/c1-16-12-28-23(13-27-16)17(2)30-25(31)19-9-20(26-29-14-24(34-26)18-5-3-6-18)11-22(10-19)33-15-21-7-4-8-32-21/h9-14,17-18,21H,3-8,15H2,1-2H3,(H,30,31)/t17-,21-/m1/s1 BHRXSWOPMLFOCG-DYESRHJHSA-N 320104 3-(5-cyclobutyl- 1,3-thiazol-2-yl)- N-[(1R)-1-(5- methylpyrazin-2- yl)ethyl]-5-[(2R)- tetrahydrofuran-2- ylmethoxy] benzamide::US10174016, Example 271::US10202369, Example 271 P2X purinoceptor 3 Homo sapiens 45.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320104 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320104&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397691 384223378 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625830 C[C@@H](NC(=O)c1cc(OC[C@H]2CCCO2)cc(c1)-c1ncc(s1)C1CCC1)c1cnc(nc1)C(F)(F)F InChI=1S/C26H27F3N4O3S/c1-15(19-11-31-25(32-12-19)26(27,28)29)33-23(34)17-8-18(24-30-13-22(37-24)16-4-2-5-16)10-21(9-17)36-14-20-6-3-7-35-20/h8-13,15-16,20H,2-7,14H2,1H3,(H,33,34)/t15-,20-/m1/s1 ZERBIURYMMOJBU-FOIQADDNSA-N 320105 3-(5-cyclobutyl- 1,3-thiazol-2-yl)-5- [(2R)- tetrahydrofuran-2- ylmethoxy]-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 272::US10202369, Example 272 P2X purinoceptor 3 Homo sapiens 19.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320105 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320105&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397162 384223379 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625832 CC(C)c1cnc(s1)-c1cc(OC[C@H]2CCCO2)cc(c1)C(=O)N[C@H](C)c1ccc(C)nn1 InChI=1S/C25H30N4O3S/c1-15(2)23-13-26-25(33-23)19-10-18(11-21(12-19)32-14-20-6-5-9-31-20)24(30)27-17(4)22-8-7-16(3)28-29-22/h7-8,10-13,15,17,20H,5-6,9,14H2,1-4H3,(H,27,30)/t17-,20-/m1/s1 UAMKMSQRQBQFJK-YLJYHZDGSA-N 320106 N-[(1R)-1-(6- methylpyridazin-3- yl)ethyl]-3-[5- (propan-2-yl)-1,3- thiazol-2-yl]-5- [(2R)- tetrahydrofuran-2- ylmethoxy] benzamide::US10174016, Example 273::US10202369, Example 279 P2X purinoceptor 3 Homo sapiens 28.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320106 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320106&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397845 384223380 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625834 CC(C)c1cnc(s1)-c1cc(OC[C@H]2CCCO2)cc(c1)C(=O)N[C@H](C)c1cnc(C)cn1 InChI=1S/C25H30N4O3S/c1-15(2)23-13-28-25(33-23)19-8-18(9-21(10-19)32-14-20-6-5-7-31-20)24(30)29-17(4)22-12-26-16(3)11-27-22/h8-13,15,17,20H,5-7,14H2,1-4H3,(H,29,30)/t17-,20-/m1/s1 CNKRLRNKYMMPAE-YLJYHZDGSA-N 320107 N-[(1R)-1-(5- methylpyrazin-2- yl)ethyl]-3-[5- (propan-2-yl)-1,3- thiazol-2-yl]-5- [(2R)- tetrahydrofuran-2- ylmethoxy] benzamide::US10174016, Example 274::US10202369, Example 280 P2X purinoceptor 3 Homo sapiens 75.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320107 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320107&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397759 384223381 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625836 CC(C)c1cnc(s1)-c1cc(OC[C@H]2CCCO2)cc(c1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C25H27F3N4O3S/c1-14(2)21-12-29-23(36-21)17-7-16(8-20(9-17)35-13-19-5-4-6-34-19)22(33)32-15(3)18-10-30-24(31-11-18)25(26,27)28/h7-12,14-15,19H,4-6,13H2,1-3H3,(H,32,33)/t15-,19-/m1/s1 KTCCKJLURHRITN-DNVCBOLYSA-N 320108 3-[5-(propan-2-yl)- 1,3-thiazol-2-yl]-5- [(2R)- tetrahydrofuran-2- ylmethoxy]-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 275::US10202369, Example 281 P2X purinoceptor 3 Homo sapiens 21.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320108 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320108&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397795 384223382 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625838 CCc1cnc(s1)-c1cc(OC[C@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1ccc(C)nn1 InChI=1S/C24H28N4O3S/c1-4-21-12-25-24(32-21)19-9-18(10-20(11-19)31-14-17-7-8-30-13-17)23(29)26-16(3)22-6-5-15(2)27-28-22/h5-6,9-12,16-17H,4,7-8,13-14H2,1-3H3,(H,26,29)/t16-,17+/m1/s1 CPQUPRVXRIYFHX-SJORKVTESA-N 320109 3-(5-ethyl-1,3- thiazol-2-yl)-N- [(1R)-1-(6- methylpyridazin-3- yl)ethyl]-5-[(3S)- tetrahydrofuran-3- ylmethoxy] benzamide::US10174016, Example 276::US10472354, Example 276 P2X purinoceptor 3 Homo sapiens 10.00 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320109 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320109&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397609 384223383 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625840 CCc1cnc(s1)-c1cc(OC[C@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1cnc(C)cn1 InChI=1S/C24H28N4O3S/c1-4-21-11-27-24(32-21)19-7-18(8-20(9-19)31-14-17-5-6-30-13-17)23(29)28-16(3)22-12-25-15(2)10-26-22/h7-12,16-17H,4-6,13-14H2,1-3H3,(H,28,29)/t16-,17+/m1/s1 PZFOCXJBZDWRSU-SJORKVTESA-N 320110 3-(5-ethyl-1,3- thiazol-2-yl)-N- [(1R)-1-(5- methylpyrazin-2- yl)ethyl]-5-[(3S)- tetrahydrofuran-3- ylmethoxy] benzamide::US10174016, Example 277::US10472354, Example 277 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320110 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320110&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397468 384223384 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625842 CCc1cnc(s1)-c1cc(OC[C@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C24H25F3N4O3S/c1-3-20-11-28-22(35-20)17-6-16(7-19(8-17)34-13-15-4-5-33-12-15)21(32)31-14(2)18-9-29-23(30-10-18)24(25,26)27/h6-11,14-15H,3-5,12-13H2,1-2H3,(H,31,32)/t14-,15+/m1/s1 VOKPPDDBRIDGES-CABCVRRESA-N 320111 3-(5-ethyl-1,3- thiazol-2-yl)-5- [(3S)- tetrahydrofuran-3- ylmethoxy]-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 278::US10472354, Example 278 P2X purinoceptor 3 Homo sapiens 2.00 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320111 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320111&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397387 384223385 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625844 CC(C)c1cnc(s1)-c1cc(OC[C@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1ccc(C)nn1 InChI=1S/C25H30N4O3S/c1-15(2)23-12-26-25(33-23)20-9-19(10-21(11-20)32-14-18-7-8-31-13-18)24(30)27-17(4)22-6-5-16(3)28-29-22/h5-6,9-12,15,17-18H,7-8,13-14H2,1-4H3,(H,27,30)/t17-,18+/m1/s1 HVLSFPXITWENER-MSOLQXFVSA-N 320112 N-[(1R)-1-(6- methylpyridazin-3- yl)ethyl]-3-[5- (propan-2-yl)-1,3- thiazol-2-yl]-5- [(3S)- tetrahydrofuran-3- ylmethoxy] benzamide::US10174016, Example 279::US10472354, Example 279 P2X purinoceptor 3 Homo sapiens 115 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320112 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320112&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397672 384223386 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625846 CC(C)c1cnc(s1)-c1cc(OC[C@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1cnc(C)cn1 InChI=1S/C25H30N4O3S/c1-15(2)23-12-28-25(33-23)20-7-19(8-21(9-20)32-14-18-5-6-31-13-18)24(30)29-17(4)22-11-26-16(3)10-27-22/h7-12,15,17-18H,5-6,13-14H2,1-4H3,(H,29,30)/t17-,18+/m1/s1 MWBSFWZECXCRJX-MSOLQXFVSA-N 320113 N-[(1R)-1-(5- methylpyrazin-2- yl)ethyl]-3-[5- (propan-2-yl)-1,3- thiazol-2-yl]-5- [(3S)- tetrahydrofuran-3- ylmethoxy] benzamide::US10174016, Example 280::US10472354, Example 280 P2X purinoceptor 3 Homo sapiens 51.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320113 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320113&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397160 384223387 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625848 CC(C)c1cnc(s1)-c1cc(OC[C@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C25H27F3N4O3S/c1-14(2)21-11-29-23(36-21)18-6-17(7-20(8-18)35-13-16-4-5-34-12-16)22(33)32-15(3)19-9-30-24(31-10-19)25(26,27)28/h6-11,14-16H,4-5,12-13H2,1-3H3,(H,32,33)/t15-,16+/m1/s1 JZRSBKDBMGCFDH-CVEARBPZSA-N 320114 3-[5-(propan-2-yl)- 1,3-thiazol-2-yl]-5- [(3S)- tetrahydrofuran-3- ylmethoxy]-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 281::US10472354, Example 281 P2X purinoceptor 3 Homo sapiens 26.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320114 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320114&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397335 384223388 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625850 CCc1cnc(s1)-c1cc(OC[C@@H]2CCCO2)cc(c1)C(=O)N[C@H](C)c1ccc(C)nn1 InChI=1S/C24H28N4O3S/c1-4-21-13-25-24(32-21)18-10-17(11-20(12-18)31-14-19-6-5-9-30-19)23(29)26-16(3)22-8-7-15(2)27-28-22/h7-8,10-13,16,19H,4-6,9,14H2,1-3H3,(H,26,29)/t16-,19+/m1/s1 CEYURJDFNAEZIM-APWZRJJASA-N 320115 3-(5-ethyl-1,3- thiazol-2-yl)-N- [(1R)-1-(6- methylpyridazin-3- yl)ethyl]-5-[(2S)- tetrahydrofuran-2- ylmethoxy] benzamide::US10174016, Example 282::US10202369, Example 282 P2X purinoceptor 3 Homo sapiens 8.00 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320115 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320115&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397632 384223389 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625852 CCc1cnc(s1)-c1cc(OC[C@@H]2CCCO2)cc(c1)C(=O)N[C@H](C)c1cnc(C)cn1 InChI=1S/C24H28N4O3S/c1-4-21-12-27-24(32-21)18-8-17(9-20(10-18)31-14-19-6-5-7-30-19)23(29)28-16(3)22-13-25-15(2)11-26-22/h8-13,16,19H,4-7,14H2,1-3H3,(H,28,29)/t16-,19+/m1/s1 AKBLPSFNNBDTQK-APWZRJJASA-N 320116 3-(5-ethyl-1,3- thiazol-2-yl)-N- [(1R)-1-(5- methylpyrazin-2- yl)ethyl]-5-[(2S)- tetrahydrofuran-2- ylmethoxy] benzamide::US10174016, Example 283::US10202369, Example 283 P2X purinoceptor 3 Homo sapiens 10.00 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320116 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320116&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397578 384223390 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625854 CCc1cnc(s1)-c1cc(OC[C@@H]2CCCO2)cc(c1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C24H25F3N4O3S/c1-3-20-12-28-22(35-20)16-7-15(8-19(9-16)34-13-18-5-4-6-33-18)21(32)31-14(2)17-10-29-23(30-11-17)24(25,26)27/h7-12,14,18H,3-6,13H2,1-2H3,(H,31,32)/t14-,18+/m1/s1 IDFXYIYQWCENGA-KDOFPFPSSA-N 320117 3-(5-ethyl-1,3- thiazol-2-yl)-5- [(2S)- tetrahydrofuran-2- ylmethoxy]-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 284::US10202369, Example 284::US10472354, Example 284 P2X purinoceptor 3 Homo sapiens 4.00 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320117 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320117&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397623 384223391 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625856 C[C@@H](NC(=O)c1cc(OC[C@@H]2CCCO2)cc(c1)-c1ncc(s1)C1CCC1)c1ccc(C)nn1 InChI=1S/C26H30N4O3S/c1-16-8-9-23(30-29-16)17(2)28-25(31)19-11-20(26-27-14-24(34-26)18-5-3-6-18)13-22(12-19)33-15-21-7-4-10-32-21/h8-9,11-14,17-18,21H,3-7,10,15H2,1-2H3,(H,28,31)/t17-,21+/m1/s1 NLLVDMMXBRFWGS-UTKZUKDTSA-N 320118 3-(5-cyclobutyl- 1,3-thiazol-2-yl)- N-[(1R)-1-(6- methylpyridazin-3- yl)ethyl]-5-[(2S)- tetrahydrofuran-2- ylmethoxy] benzamide::US10174016, Example 285::US10202369, Example 285::US10472354, Example 285 P2X purinoceptor 3 Homo sapiens 113 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320118 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320118&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397163 384223392 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625858 C[C@@H](NC(=O)c1cc(OC[C@@H]2CCCO2)cc(c1)-c1ncc(s1)C1CCC1)c1cnc(C)cn1 InChI=1S/C26H30N4O3S/c1-16-12-28-23(13-27-16)17(2)30-25(31)19-9-20(26-29-14-24(34-26)18-5-3-6-18)11-22(10-19)33-15-21-7-4-8-32-21/h9-14,17-18,21H,3-8,15H2,1-2H3,(H,30,31)/t17-,21+/m1/s1 BHRXSWOPMLFOCG-UTKZUKDTSA-N 320119 3-(5-cyclobutyl- 1,3-thiazol-2-yl)- N-[(1R)-1-(5- methylpyrazin-2- yl)ethyl]-5-[(2S)- tetrahydrofuran-2- ylmethoxy]benzamide::US10174016, Example 286::US10202369, Example 286::US10472354, Example 286 P2X purinoceptor 3 Homo sapiens 87.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320119 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320119&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397754 384223393 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625860 C[C@@H](NC(=O)c1cc(OC[C@@H]2CCCO2)cc(c1)-c1ncc(s1)C1CCC1)c1cnc(nc1)C(F)(F)F InChI=1S/C26H27F3N4O3S/c1-15(19-11-31-25(32-12-19)26(27,28)29)33-23(34)17-8-18(24-30-13-22(37-24)16-4-2-5-16)10-21(9-17)36-14-20-6-3-7-35-20/h8-13,15-16,20H,2-7,14H2,1H3,(H,33,34)/t15-,20+/m1/s1 ZERBIURYMMOJBU-QRWLVFNGSA-N 320120 3-(5-cyclobutyl- 1,3-thiazol-2-yl)-5- [(2S)- tetrahydrofuran-2- ylmethoxy]-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 287::US10202369, Example 287::US10472354, Example 287 P2X purinoceptor 3 Homo sapiens 35.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320120 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320120&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397159 384223394 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625862 CC(C)c1cnc(s1)-c1cc(OC[C@@H]2CCCO2)cc(c1)C(=O)N[C@H](C)c1ccc(C)nn1 InChI=1S/C25H30N4O3S/c1-15(2)23-13-26-25(33-23)19-10-18(11-21(12-19)32-14-20-6-5-9-31-20)24(30)27-17(4)22-8-7-16(3)28-29-22/h7-8,10-13,15,17,20H,5-6,9,14H2,1-4H3,(H,27,30)/t17-,20+/m1/s1 UAMKMSQRQBQFJK-XLIONFOSSA-N 320121 N-[(1R)-1-(6- methylpyridazin-3- yl)ethyl]-3-[5- (propan-2-yl)-1,3- thiazol-2-yl]-5- [(2S)- tetrahydrofuran-2- ylmethoxy] benzamide::US10174016, Example 288::US10202369, Example 288::US10472354, Example 288 P2X purinoceptor 3 Homo sapiens 150 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320121 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320121&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397738 384223395 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625864 CC(C)c1cnc(s1)-c1cc(OC[C@@H]2CCCO2)cc(c1)C(=O)N[C@H](C)c1cnc(C)cn1 InChI=1S/C25H30N4O3S/c1-15(2)23-13-28-25(33-23)19-8-18(9-21(10-19)32-14-20-6-5-7-31-20)24(30)29-17(4)22-12-26-16(3)11-27-22/h8-13,15,17,20H,5-7,14H2,1-4H3,(H,29,30)/t17-,20+/m1/s1 CNKRLRNKYMMPAE-XLIONFOSSA-N 320122 N-[(1R)-1-(5- methylpyrazin-2- yl)ethyl]-3-[5- (propan-2-yl)-1,3- thiazol-2-yl]-5- [(2S)- tetrahydrofuran-2- ylmethoxy]benzamide::US10174016, Example 289::US10202369, Example 289::US10472354, Example 289 P2X purinoceptor 3 Homo sapiens 192 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320122 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320122&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397419 384223396 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625866 CC(C)c1cnc(s1)-c1cc(OC[C@@H]2CCCO2)cc(c1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C25H27F3N4O3S/c1-14(2)21-12-29-23(36-21)17-7-16(8-20(9-17)35-13-19-5-4-6-34-19)22(33)32-15(3)18-10-30-24(31-11-18)25(26,27)28/h7-12,14-15,19H,4-6,13H2,1-3H3,(H,32,33)/t15-,19+/m1/s1 KTCCKJLURHRITN-BEFAXECRSA-N 320123 3-[5-(propan-2-yl)- 1,3-thiazol-2-yl]-5- [(2S)- tetrahydrofuran-2- ylmethoxy]-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 290::US10472354, Example 290 P2X purinoceptor 3 Homo sapiens 31.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320123 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320123&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397222 384223397 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625868 C[C@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C22H21F3N4O3S/c1-12-8-26-20(33-12)15-5-14(6-18(7-15)32-17-3-4-31-11-17)19(30)29-13(2)16-9-27-21(28-10-16)22(23,24)25/h5-10,13,17H,3-4,11H2,1-2H3,(H,29,30)/t13-,17+/m0/s1 GTQPEQGDLVSFJO-SUMWQHHRSA-N 320124 3-(5-methyl-1,3- thiazol-2-yl)-5- [(3R)- tetrahydrofuran-3- yloxy]-N-{(1S)-1- [2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 291::US10202369, Example 291 P2X purinoceptor 3 Homo sapiens 1320 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320124 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320124&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397365 384223398 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625870 CCc1cnc(s1)-c1cc(OC[C@@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1ccc(nn1)C(F)(F)F InChI=1S/C24H25F3N4O3S/c1-3-19-11-28-23(35-19)17-8-16(9-18(10-17)34-13-15-6-7-33-12-15)22(32)29-14(2)20-4-5-21(31-30-20)24(25,26)27/h4-5,8-11,14-15H,3,6-7,12-13H2,1-2H3,(H,29,32)/t14-,15-/m1/s1 PGRAVNCJCWWOPT-HUUCEWRRSA-N 320125 3-(5-ethyl-1,3- thiazol-2-yl)-5- [(3R)- tetrahydrofuran-3- ylmethoxy]-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3-yl] ethyl}benzamide::US10174016, Example 292::US10202369, Example 292 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320125 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320125&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397547 384223399 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625872 CC(C)c1cnc(s1)-c1cc(OC[C@@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1ccc(nn1)C(F)(F)F InChI=1S/C25H27F3N4O3S/c1-14(2)21-11-29-24(36-21)18-8-17(9-19(10-18)35-13-16-6-7-34-12-16)23(33)30-15(3)20-4-5-22(32-31-20)25(26,27)28/h4-5,8-11,14-16H,6-7,12-13H2,1-3H3,(H,30,33)/t15-,16-/m1/s1 ZWFOSAQPAKMJAC-HZPDHXFCSA-N 320126 3-[5-(propan-2-yl)- 1,3-thiazol-2-yl]-5- [(3R)- tetrahydrofuran-3- ylmethoxy]-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl}benzamide::US10174016, Example 293::US10202369, Example 301 P2X purinoceptor 3 Homo sapiens 63.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320126 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320126&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397373 384223400 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625874 CC(C)c1cnc(s1)-c1cc(O[C@@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1ccc(nn1)C(F)(F)F InChI=1S/C24H25F3N4O3S/c1-13(2)20-11-28-23(35-20)16-8-15(9-18(10-16)34-17-6-7-33-12-17)22(32)29-14(3)19-4-5-21(31-30-19)24(25,26)27/h4-5,8-11,13-14,17H,6-7,12H2,1-3H3,(H,29,32)/t14-,17-/m1/s1 ALCUBFBGIYQDIY-RHSMWYFYSA-N 320127 3-[5-(propan-2-yl)- 1,3-thiazol-2-yl]-5- [(3R)- tetrahydrofuran-3- yloxy]-N-{(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl}benzamide::US10174016, Example 294::US10202369, Example 294::US10472354, Example 294 P2X purinoceptor 3 Homo sapiens 101 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320127 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320127&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397844 384223401 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625876 C[C@@H](NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(s1)C1CCC1)c1ccc(nn1)C(F)(F)F InChI=1S/C25H25F3N4O3S/c1-14(20-5-6-22(32-31-20)25(26,27)28)30-23(33)16-9-17(11-19(10-16)35-18-7-8-34-13-18)24-29-12-21(36-24)15-3-2-4-15/h5-6,9-12,14-15,18H,2-4,7-8,13H2,1H3,(H,30,33)/t14-,18+/m1/s1 LCHSLMNVJPMESH-KDOFPFPSSA-N 320128 3-(5-cyclobutyl- 1,3-thiazol-2-yl)-5- [(3S)- tetrahydrofuran-3- yloxy]-N-{(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl}benzamide::US10174016, Example 295::US10202369, Example 295::US10472354, Example 295 P2X purinoceptor 3 Homo sapiens 55.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320128 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320128&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397441 384223402 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625878 CCc1cnc(s1)-c1cc(OC[C@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1ccc(nn1)C(F)(F)F InChI=1S/C24H25F3N4O3S/c1-3-19-11-28-23(35-19)17-8-16(9-18(10-17)34-13-15-6-7-33-12-15)22(32)29-14(2)20-4-5-21(31-30-20)24(25,26)27/h4-5,8-11,14-15H,3,6-7,12-13H2,1-2H3,(H,29,32)/t14-,15+/m1/s1 PGRAVNCJCWWOPT-CABCVRRESA-N 320129 3-(5-ethyl-1,3- thiazol-2-yl)-5- [(3S)- tetrahydrofuran-3- ylmethoxy]-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl}benzamide::US10174016, Example 296::US10202369, Example 296::US10472354, Example 296 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320129 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320129&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397487 384223403 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625880 C[C@@H](NC(=O)c1cc(OC[C@@H]2CCOC2)cc(c1)-c1ncc(s1)C1CCC1)c1ccc(nn1)C(F)(F)F InChI=1S/C26H27F3N4O3S/c1-15(21-5-6-23(33-32-21)26(27,28)29)31-24(34)18-9-19(25-30-12-22(37-25)17-3-2-4-17)11-20(10-18)36-14-16-7-8-35-13-16/h5-6,9-12,15-17H,2-4,7-8,13-14H2,1H3,(H,31,34)/t15-,16-/m1/s1 BURFLVDKSSJHQL-HZPDHXFCSA-N 320130 3-(5-cyclobutyl- 1,3-thiazol-2-yl)-5- [(3R)- tetrahydrofuran-3- ylmethoxy]-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl}benzamide::US10174016, Example 297::US10202369, Example 300::US10472354, Example 297 P2X purinoceptor 3 Homo sapiens 56.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320130 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320130&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397174 384223404 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625882 CC(C)c1cnc(s1)-c1cc(OC[C@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1ccc(nn1)C(F)(F)F InChI=1S/C25H27F3N4O3S/c1-14(2)21-11-29-24(36-21)18-8-17(9-19(10-18)35-13-16-6-7-34-12-16)23(33)30-15(3)20-4-5-22(32-31-20)25(26,27)28/h4-5,8-11,14-16H,6-7,12-13H2,1-3H3,(H,30,33)/t15-,16+/m1/s1 ZWFOSAQPAKMJAC-CVEARBPZSA-N 320131 3-[5-(propan-2-yl)- 1,3-thiazol-2-yl]-5- [(3S)- tetrahydrofuran-3- ylmethoxy]-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl}benzamide::US10174016, Example 298::US10202369, Example 299::US10472354, Example 298 P2X purinoceptor 3 Homo sapiens 62.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320131 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320131&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397407 384223405 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625884 CC(C)c1cnc(s1)-c1cc(OC[C@H]2CCCO2)cc(c1)C(=O)N[C@H](C)c1ccc(nn1)C(F)(F)F InChI=1S/C25H27F3N4O3S/c1-14(2)21-12-29-24(36-21)17-9-16(10-19(11-17)35-13-18-5-4-8-34-18)23(33)30-15(3)20-6-7-22(32-31-20)25(26,27)28/h6-7,9-12,14-15,18H,4-5,8,13H2,1-3H3,(H,30,33)/t15-,18-/m1/s1 QOJBRGRPZKZVKC-CRAIPNDOSA-N 320132 3-[5-(propan-2-yl)- 1,3-thiazol-2-yl]-5- [(2R)- tetrahydrofuran-2- ylmethoxy]-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl}benzamide::US10174016, Example 299::US10472354, Example 299 P2X purinoceptor 3 Homo sapiens 37.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320132 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320132&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397251 384223406 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625886 C[C@@H](NC(=O)c1cc(OC[C@@H]2CCCO2)cc(c1)-c1ncc(s1)C1CCC1)c1ccc(nn1)C(F)(F)F InChI=1S/C26H27F3N4O3S/c1-15(21-7-8-23(33-32-21)26(27,28)29)31-24(34)17-10-18(25-30-13-22(37-25)16-4-2-5-16)12-20(11-17)36-14-19-6-3-9-35-19/h7-8,10-13,15-16,19H,2-6,9,14H2,1H3,(H,31,34)/t15-,19+/m1/s1 BFQOMUOMPPUOAS-BEFAXECRSA-N 320133 3-(5-cyclobutyl- 1,3-thiazol-2-yl)-5- [(2S)- tetrahydrofuran-2- ylmethoxy]-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl}benzamide::US10174016, Example 300::US10472354, Example 300 P2X purinoceptor 3 Homo sapiens 78.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320133 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320133&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397755 384223407 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625888 CC(C)c1cnc(s1)-c1cc(OC[C@@H]2CCCO2)cc(c1)C(=O)N[C@H](C)c1ccc(nn1)C(F)(F)F InChI=1S/C25H27F3N4O3S/c1-14(2)21-12-29-24(36-21)17-9-16(10-19(11-17)35-13-18-5-4-8-34-18)23(33)30-15(3)20-6-7-22(32-31-20)25(26,27)28/h6-7,9-12,14-15,18H,4-5,8,13H2,1-3H3,(H,30,33)/t15-,18+/m1/s1 QOJBRGRPZKZVKC-QAPCUYQASA-N 320134 3-[5-(propan-2-yl)- 1,3-thiazol-2-yl]-5- [(2S)- tetrahydrofuran-2- ylmethoxy]-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl}benzamide::US10174016, Example 301::US10472354, Example 301 P2X purinoceptor 3 Homo sapiens 91.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320134 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320134&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397464 384223408 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625890 CCc1cnc(s1)-c1cc(OC[C@@H]2CCCO2)cc(c1)C(=O)N[C@H](C)c1ccc(nn1)C(F)(F)F InChI=1S/C24H25F3N4O3S/c1-3-19-12-28-23(35-19)16-9-15(10-18(11-16)34-13-17-5-4-8-33-17)22(32)29-14(2)20-6-7-21(31-30-20)24(25,26)27/h6-7,9-12,14,17H,3-5,8,13H2,1-2H3,(H,29,32)/t14-,17+/m1/s1 JBKILHBMFZDIIA-PBHICJAKSA-N 320135 3-(5-ethyl-1,3- thiazol-2-yl)-5- [(2S)- tetrahydrofuran-2- ylmethoxy]-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl}benzamide::US10174016, Example 302::US10202369, Example 302::US10472354, Example 302 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320135 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320135&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397753 384223409 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625892 C[C@@H](NC(=O)c1cc(OC2CCN(CC(F)(F)F)CC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C25H25F6N5O2S/c1-14-10-32-22(39-14)17-7-16(21(37)35-15(2)18-11-33-23(34-12-18)25(29,30)31)8-20(9-17)38-19-3-5-36(6-4-19)13-24(26,27)28/h7-12,15,19H,3-6,13H2,1-2H3,(H,35,37)/t15-/m1/s1 HEBACSHOFHMYBR-OAHLLOKOSA-N 320136 3-(5-methyl-1,3- thiazol-2-yl)-5-{[1- (2,2,2- trifluoroethyl) piperidin-4-yl]oxy}- N-{(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 303::US10202369, Example 310::US10472354, Example 303 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320136 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320136&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397490 384223410 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625894 C[C@@H](NC(=O)c1cc(OC2CCN(CC(F)F)CC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C25H26F5N5O2S/c1-14-10-31-23(38-14)17-7-16(8-20(9-17)37-19-3-5-35(6-4-19)13-21(26)27)22(36)34-15(2)18-11-32-24(33-12-18)25(28,29)30/h7-12,15,19,21H,3-6,13H2,1-2H3,(H,34,36)/t15-/m1/s1 LOLIYPRJHUXCPO-OAHLLOKOSA-N 320137 3-{[1-(2,2- difluoroethyl) piperidin-4-yl]oxy}- 5-(5-methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoroethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 304::US10202369, Example 308::US10472354, Example 304 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320137 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320137&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397386 384223411 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625896 C[C@@H](NC(=O)c1cc(OC2CCN(CC(F)F)CC2)cc(c1)-c1ncc(C)s1)c1ccc(C)nn1 InChI=1S/C25H29F2N5O2S/c1-15-4-5-22(31-30-15)17(3)29-24(33)18-10-19(25-28-13-16(2)35-25)12-21(11-18)34-20-6-8-32(9-7-20)14-23(26)27/h4-5,10-13,17,20,23H,6-9,14H2,1-3H3,(H,29,33)/t17-/m1/s1 BZVNHOBJGKGQCM-QGZVFWFLSA-N 320138 3-{[1-(2,2- difluoroethyl) piperidin-4-yl]oxy}-N- [(1R)-1-(6- methylpyridazin-3- yl)ethyl]-5-(5- methyl-1,3- thiazol-2-yl) benzamide::US10174016, Example 305::US10202369, Example 305::US10472354, Example 305 P2X purinoceptor 3 Homo sapiens 9.00 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320138 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320138&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397226 384223412 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625898 C[C@@H](NC(=O)c1cc(OC2CCN(CC(F)F)CC2)cc(c1)-c1ncc(C)s1)c1cnc(C)cn1 InChI=1S/C25H29F2N5O2S/c1-15-11-29-22(13-28-15)17(3)31-24(33)18-8-19(25-30-12-16(2)35-25)10-21(9-18)34-20-4-6-32(7-5-20)14-23(26)27/h8-13,17,20,23H,4-7,14H2,1-3H3,(H,31,33)/t17-/m1/s1 OVUBAZICSOPILB-QGZVFWFLSA-N 320139 3-{[1-(2,2- difluoroethyl) piperidin-4-yl]oxy}-N- [(1R)-1-(5- methylpyrazin-2- yl)ethyl]-5-(5- methyl-1,3- thiazol-2-yl) benzamide::US10174016, Example 306::US10202369, Example 306::US10472354, Example 306 P2X purinoceptor 3 Homo sapiens 42.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320139 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320139&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397132 384223413 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625900 Cc1cnc(s1)-c1cc(OC2CCN(CC(F)F)CC2)cc(c1)C(=O)NCc1ccc(C)nn1 InChI=1S/C24H27F2N5O2S/c1-15-3-4-19(30-29-15)13-27-23(32)17-9-18(24-28-12-16(2)34-24)11-21(10-17)33-20-5-7-31(8-6-20)14-22(25)26/h3-4,9-12,20,22H,5-8,13-14H2,1-2H3,(H,27,32) AGOFJROZQVOSRF-UHFFFAOYSA-N 320140 3-{[1-(2,2- difluoroethyl)piperidin- 4-yl]oxy}-N- [(6-methylpyridazin- 3-yl)methyl]-5-(5- methyl-1,3-thiazol-2- yl)benzamide::US10174016, Example 307::US10202369, Example 307::US10472354, Example 307 P2X purinoceptor 3 Homo sapiens 16.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320140 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320140&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397369 384223414 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625902 C[C@H](NC(=O)c1cc(OC2CCN(CC(F)F)CC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C25H26F5N5O2S/c1-14-10-31-23(38-14)17-7-16(8-20(9-17)37-19-3-5-35(6-4-19)13-21(26)27)22(36)34-15(2)18-11-32-24(33-12-18)25(28,29)30/h7-12,15,19,21H,3-6,13H2,1-2H3,(H,34,36)/t15-/m0/s1 LOLIYPRJHUXCPO-HNNXBMFYSA-N 320141 3-{[1-(2,2- difluoroethyl)piperidin- 4-yl]oxy}-5-(5- methyl-1,3-thiazol-2- yl)-N- {(1S)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 308::US10472354, Example 308 P2X purinoceptor 3 Homo sapiens 153 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320141 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320141&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397709 384223415 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625904 C[C@@H](NC(=O)c1cc(OC2CCN(CC(F)F)CC2)cc(c1)-c1ncc(C)s1)c1cnc(C)nc1 InChI=1S/C25H29F2N5O2S/c1-15-11-30-25(35-15)19-8-18(24(33)31-16(2)20-12-28-17(3)29-13-20)9-22(10-19)34-21-4-6-32(7-5-21)14-23(26)27/h8-13,16,21,23H,4-7,14H2,1-3H3,(H,31,33)/t16-/m1/s1 XIVLMPYTLPVWPV-MRXNPFEDSA-N 320142 3-{[1-(2,2- difluoroethyl)piperidin- 4-yl]oxy}-N- [(1R)-1-(2- methylpyrimidin- 5-yl)ethyl]-5-(5- methyl-1,3-thiazol-2- yl)benzamide::US10174016, Example 309::US10202369, Example 309::US10472354, Example 309 P2X purinoceptor 3 Homo sapiens 8.00 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320142 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320142&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397638 384223416 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625906 C[C@H](NC(=O)c1cc(OC2CCN(CC(F)(F)F)CC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C25H25F6N5O2S/c1-14-10-32-22(39-14)17-7-16(21(37)35-15(2)18-11-33-23(34-12-18)25(29,30)31)8-20(9-17)38-19-3-5-36(6-4-19)13-24(26,27)28/h7-12,15,19H,3-6,13H2,1-2H3,(H,35,37)/t15-/m0/s1 HEBACSHOFHMYBR-HNNXBMFYSA-N 320143 3-(5-methyl-1,3- thiazol-2-yl)-5-{[1- (2,2,2- trifluoroethyl) piperidin-4-yl]oxy}-N- {(1S)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 310::US10472354, Example 310 P2X purinoceptor 3 Homo sapiens 116 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320143 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320143&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397431 384223417 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625908 C[C@@H](NC(=O)c1cc(OC2CCN(CC(F)(F)F)CC2)cc(c1)-c1ncc(C)s1)c1ccc(C)nn1 InChI=1S/C25H28F3N5O2S/c1-15-4-5-22(32-31-15)17(3)30-23(34)18-10-19(24-29-13-16(2)36-24)12-21(11-18)35-20-6-8-33(9-7-20)14-25(26,27)28/h4-5,10-13,17,20H,6-9,14H2,1-3H3,(H,30,34)/t17-/m1/s1 PEAPNGOBIXQGEJ-QGZVFWFLSA-N 320144 N-[(1R)-1-(6- methylpyridazin-3- yl)ethyl]-3-(5- methyl-1,3- thiazol-2-yl)-5-{[1- (2,2,2- trifluoroethyl) piperidin-4-yl]oxy} benzamide::US10174016, Example 311::US10202369, Example 311::US10472354, Example 314 P2X purinoceptor 3 Homo sapiens 8.00 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320144 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320144&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397300 384223418 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625910 C[C@@H](NC(=O)c1cc(OC2CCN(CC(F)(F)F)CC2)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F InChI=1S/C25H25F6N5O2S/c1-14-12-32-23(39-14)17-9-16(22(37)33-15(2)20-3-4-21(35-34-20)25(29,30)31)10-19(11-17)38-18-5-7-36(8-6-18)13-24(26,27)28/h3-4,9-12,15,18H,5-8,13H2,1-2H3,(H,33,37)/t15-/m1/s1 AZRJUXHXOIFVSM-OAHLLOKOSA-N 320145 3-(5-methyl-1,3- thiazol-2-yl)-5-{[1- (2,2,2- trifluoroethyl) piperidin-4-yl]oxy}-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl}benzamide::US10174016, Example 312::US10202369, Example 312::US10472354, Example 312 P2X purinoceptor 3 Homo sapiens 9.00 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320145 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320145&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397364 384223419 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625912 C[C@@H](NC(=O)c1cc(OC2CCN(CC(F)(F)F)CC2)cc(c1)-c1ncc(C)s1)c1cnc(C)cn1 InChI=1S/C25H28F3N5O2S/c1-15-11-30-22(13-29-15)17(3)32-23(34)18-8-19(24-31-12-16(2)36-24)10-21(9-18)35-20-4-6-33(7-5-20)14-25(26,27)28/h8-13,17,20H,4-7,14H2,1-3H3,(H,32,34)/t17-/m1/s1 VOYLEHBGAUIAGN-QGZVFWFLSA-N 320146 N-[(1R)-1-(5- methylpyrazin-2- yl)ethyl]-3-(5- methyl-1,3- thiazol-2-yl)-5-{[1- (2,2,2- trifluoroethyl) piperidin-4- yl]oxy}benzamide::US10174016, Example 313::US10202369, Example 313::US10472354, Example 313 P2X purinoceptor 3 Homo sapiens 11.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320146 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320146&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397805 384223420 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625914 Cc1cnc(s1)-c1cc(OC2CCN(CC(F)(F)F)CC2)cc(c1)C(=O)NCc1ccc(C)nn1 InChI=1S/C24H26F3N5O2S/c1-15-3-4-19(31-30-15)13-28-22(33)17-9-18(23-29-12-16(2)35-23)11-21(10-17)34-20-5-7-32(8-6-20)14-24(25,26)27/h3-4,9-12,20H,5-8,13-14H2,1-2H3,(H,28,33) OUYWWDOEFAUISF-UHFFFAOYSA-N 320147 N-[(6- methylpyridazin-3- yl)methyl]-3-(5- methyl-1,3- thiazol-2-yl)-5-{[1- (2,2,2- trifluoroethyl) piperidin-4-yl]oxy} benzamide::US10174016, Example 314::US10202369, Example 314 P2X purinoceptor 3 Homo sapiens 8.00 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320147 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320147&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397402 384223421 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625916 C[C@@H](NC(=O)c1cc(OC2CCN(CC(F)(F)F)CC2)cc(c1)-c1ncc(C)s1)c1cnc(C)nc1 InChI=1S/C25H28F3N5O2S/c1-15-11-31-24(36-15)19-8-18(23(34)32-16(2)20-12-29-17(3)30-13-20)9-22(10-19)35-21-4-6-33(7-5-21)14-25(26,27)28/h8-13,16,21H,4-7,14H2,1-3H3,(H,32,34)/t16-/m1/s1 CJWKMIQNKLHRQL-MRXNPFEDSA-N 320148 N-[(1R)-1-(2- methylpyrimidin- 5-yl)ethyl]-3-(5- methyl-1,3- thiazol-2-yl)-5-{[1- (2,2,2- trifluoroethyl) piperidin-4-yl]oxy} benzamide::US10174016, Example 315::US10202369, Example 315::US10472354, Example 315 P2X purinoceptor 3 Homo sapiens 8.00 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320148 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320148&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397608 384223422 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625918 C[C@@H](NC(=O)c1cc(OC[C@H]2CCOC2)cc(c1)-c1ncc(Cl)s1)c1ccc(C)nn1 InChI=1S/C22H23ClN4O3S/c1-13-3-4-19(27-26-13)14(2)25-21(28)16-7-17(22-24-10-20(23)31-22)9-18(8-16)30-12-15-5-6-29-11-15/h3-4,7-10,14-15H,5-6,11-12H2,1-2H3,(H,25,28)/t14-,15+/m1/s1 OPFRVFRBCBSDJR-CABCVRRESA-N 320149 3-(5-chloro-1,3- thiazol-2-yl)-N- [(1R)-1-(6- methylpyridazin-3- yl)ethyl]-5-[(3S)- tetrahydrofuran-3- ylmethoxy]benzamide::US10174016, Example 316::US10472354, Example 316 P2X purinoceptor 3 Homo sapiens 21.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320149 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320149&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397598 384223423 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625920 C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(Cl)s1)c1ccc(C)nn1 InChI=1S/C21H21ClN4O3S/c1-12-3-4-18(26-25-12)13(2)24-20(27)14-7-15(21-23-10-19(22)30-21)9-17(8-14)29-16-5-6-28-11-16/h3-4,7-10,13,16H,5-6,11H2,1-2H3,(H,24,27)/t13-,16-/m1/s1 GKNCXHRLEQHNKW-CZUORRHYSA-N 320150 3-(5-chloro-1,3- thiazol-2-yl)-N- [(1R)-1-(6- methylpyridazin-3- yl)ethyl]-5-[(3R)- tetrahydrofuran-3- yloxy]benzamide::US10174016, Example 317::US10202369, Example 317::US10472354, Example 317 P2X purinoceptor 3 Homo sapiens 45.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320150 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320150&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397433 384223424 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625922 C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(Cl)s1)c1ccc(nn1)C(F)(F)F InChI=1S/C21H18ClF3N4O3S/c1-11(16-2-3-17(29-28-16)21(23,24)25)27-19(30)12-6-13(20-26-9-18(22)33-20)8-15(7-12)32-14-4-5-31-10-14/h2-3,6-9,11,14H,4-5,10H2,1H3,(H,27,30)/t11-,14-/m1/s1 WZQSUVWYIQCPQJ-BXUZGUMPSA-N 320151 3-(5-chloro-1,3- thiazol-2-yl)-5- [(3R)- tetrahydrofuran-3- yloxy]-N-{(1R)-1- [6- (trifluoromethyl) pyridazin-3- yl]ethyl}benzamide::US10174016, Example 318::US10202369, Example 318::US10472354, Example 318 P2X purinoceptor 3 Homo sapiens 32.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320151 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320151&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397509 384223425 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625924 C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(Cl)s1)c1cnc(C)cn1 InChI=1S/C21H21ClN4O3S/c1-12-8-24-18(9-23-12)13(2)26-20(27)14-5-15(21-25-10-19(22)30-21)7-17(6-14)29-16-3-4-28-11-16/h5-10,13,16H,3-4,11H2,1-2H3,(H,26,27)/t13-,16-/m1/s1 NPEHDEPJRQIOFY-CZUORRHYSA-N 320152 3-(5-chloro-1,3- thiazol-2-yl)-N- [(1R)-1-(5- methylpyrazin-2- yl)ethyl]-5-[(3R)- tetrahydrofuran-3- yloxy]benzamide::US10174016, Example 319::US10202369, Example 319::US10472354, Example 319 P2X purinoceptor 3 Homo sapiens 76.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320152 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320152&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397412 384223426 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625926 C[C@@H](NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(Cl)s1)c1ccc(nn1)C(F)(F)F InChI=1S/C21H18ClF3N4O3S/c1-11(16-2-3-17(29-28-16)21(23,24)25)27-19(30)12-6-13(20-26-9-18(22)33-20)8-15(7-12)32-14-4-5-31-10-14/h2-3,6-9,11,14H,4-5,10H2,1H3,(H,27,30)/t11-,14+/m1/s1 WZQSUVWYIQCPQJ-RISCZKNCSA-N 320153 3-(5-chloro-1,3- thiazol-2-yl)-5- [(3S)- tetrahydrofuran-3- yloxy]-N-{(1R)-1- [6- (trifluoromethyl) pyridazin-3- yl]ethyl}benzamide::US10174016, Example 320::US10202369, Example 320::US10472354, Example 320 P2X purinoceptor 3 Homo sapiens 33.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320153 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320153&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397157 384223427 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625928 C[C@@H](NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(Cl)s1)c1cnc(C)cn1 InChI=1S/C21H21ClN4O3S/c1-12-8-24-18(9-23-12)13(2)26-20(27)14-5-15(21-25-10-19(22)30-21)7-17(6-14)29-16-3-4-28-11-16/h5-10,13,16H,3-4,11H2,1-2H3,(H,26,27)/t13-,16+/m1/s1 NPEHDEPJRQIOFY-CJNGLKHVSA-N 320154 3-(5-chloro-1,3- thiazol-2-yl)-N- [(1R)-1-(5- methylpyrazin-2- yl)ethyl]-5-[(3S)- tetrahydrofuran-3- yloxy]benzamide::US10174016, Example 321::US10202369, Example 321::US10472354, Example 321 P2X purinoceptor 3 Homo sapiens 120 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320154 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320154&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397403 384223428 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625930 C[C@@H](NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(Cl)s1)c1ccc(C)nn1 InChI=1S/C21H21ClN4O3S/c1-12-3-4-18(26-25-12)13(2)24-20(27)14-7-15(21-23-10-19(22)30-21)9-17(8-14)29-16-5-6-28-11-16/h3-4,7-10,13,16H,5-6,11H2,1-2H3,(H,24,27)/t13-,16+/m1/s1 GKNCXHRLEQHNKW-CJNGLKHVSA-N 320155 3-(5-chloro-1,3- thiazol-2-yl)-N- [(1R)-1-(6- methylpyridazin-3- yl)ethyl]-5-[(3S)- tetrahydrofuran-3- yloxy]benzamide::US10174016, Example 322::US10202369, Example 322::US10472354, Example 322 P2X purinoceptor 3 Homo sapiens 49.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320155 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320155&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397765 384223429 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625932 C[C@@H](NC(=O)c1cc(OC[C@H]2CCOC2)cc(c1)-c1ncc(Cl)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C22H20ClF3N4O3S/c1-12(16-7-28-21(29-8-16)22(24,25)26)30-19(31)14-4-15(20-27-9-18(23)34-20)6-17(5-14)33-11-13-2-3-32-10-13/h4-9,12-13H,2-3,10-11H2,1H3,(H,30,31)/t12-,13+/m1/s1 SQNSHDCXZQFUAQ-OLZOCXBDSA-N 320156 3-(5-chloro-1,3- thiazol-2-yl)-5- [(3S)- tetrahydrofuran-3- ylmethoxy]-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 323::US10202369, Example 323::US10472354, Example 323 P2X purinoceptor 3 Homo sapiens 25.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320156 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320156&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397761 384223430 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625934 C[C@@H](NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(Cl)s1)c1cnc(C)cn1 InChI=1S/C22H23ClN4O3S/c1-13-10-25-19(11-24-13)14(2)27-21(28)15-7-16(22-26-12-20(23)31-22)9-18(8-15)30-17-3-5-29-6-4-17/h7-12,14,17H,3-6H2,1-2H3,(H,27,28)/t14-/m1/s1 LHUVAVZJRUVQTK-CQSZACIVSA-N 320157 3-(5-chloro-1,3- thiazol-2-yl)-N- [(1R)-1-(5- methylpyrazin-2- yl)ethyl]-5- (tetrahydro-2H- pyran-4- yloxy)benzamide::US10174016, Example 324::US10202369, Example 324::US10472354, Example 324 P2X purinoceptor 3 Homo sapiens 46.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320157 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320157&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397374 384223431 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625936 C[C@@H](NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(Cl)s1)c1ccc(C)nn1 InChI=1S/C22H23ClN4O3S/c1-13-3-4-19(27-26-13)14(2)25-21(28)15-9-16(22-24-12-20(23)31-22)11-18(10-15)30-17-5-7-29-8-6-17/h3-4,9-12,14,17H,5-8H2,1-2H3,(H,25,28)/t14-/m1/s1 WDEIMZWFSWTCLU-CQSZACIVSA-N 320158 3-(5-chloro-1,3- thiazol-2-yl)-N- [(1R)-1-(6- methylpyridazin-3- yl)ethyl]-5- (tetrahydro-2H- pyran-4- yloxy)benzamide::US10174016, Example 325::US10202369, Example 325::US10472354, Example 325 P2X purinoceptor 3 Homo sapiens 26.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320158 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320158&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397325 384223432 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625938 C[C@@H](NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(Cl)s1)c1ccc(nn1)C(F)(F)F InChI=1S/C22H20ClF3N4O3S/c1-12(17-2-3-18(30-29-17)22(24,25)26)28-20(31)13-8-14(21-27-11-19(23)34-21)10-16(9-13)33-15-4-6-32-7-5-15/h2-3,8-12,15H,4-7H2,1H3,(H,28,31)/t12-/m1/s1 LBZPSHGDCXIMLR-GFCCVEGCSA-N 320159 3-(5-chloro-1,3- thiazol-2-yl)-5- (tetrahydro-2H- pyran-4-yloxy)-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl}benzamide::US10174016, Example 326::US10202369, Example 326::US10472354, Example 326 P2X purinoceptor 3 Homo sapiens 21.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320159 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320159&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397539 384223433 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625940 C[C@@H](NC(=O)c1cc(OCC2(C)COC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H23F3N4O3S/c1-13-7-27-20(34-13)16-4-15(5-18(6-16)33-12-22(3)10-32-11-22)19(31)30-14(2)17-8-28-21(29-9-17)23(24,25)26/h4-9,14H,10-12H2,1-3H3,(H,30,31)/t14-/m1/s1 JVDZTZBJXQINIP-CQSZACIVSA-N 320160 3-[(3- methyloxetan-3- yl)methoxy]-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 327::US10202369, Example 327::US10472354, Example 327 P2X purinoceptor 3 Homo sapiens 10.00 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320160 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320160&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397492 384223434 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625942 C[C@@H](NC(=O)c1cc(OCC(C)(C)O)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C22H23F3N4O3S/c1-12-8-26-19(33-12)15-5-14(6-17(7-15)32-11-21(3,4)31)18(30)29-13(2)16-9-27-20(28-10-16)22(23,24)25/h5-10,13,31H,11H2,1-4H3,(H,29,30)/t13-/m1/s1 CJANIGLDVDYTLU-CYBMUJFWSA-N 320161 3-(2-hydroxy-2- methylpropoxy)-5- (5-methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5-yl]ethyl} benzamide::US10174016, Example 328::US10472354, Example 328 P2X purinoceptor 3 Homo sapiens 12.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320161 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320161&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397727 384223435 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625944 C[C@@H](NC(=O)c1cc(OCC2(C)CCCO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H25F3N4O3S/c1-14-10-28-21(35-14)17-7-16(8-19(9-17)33-13-23(3)5-4-6-34-23)20(32)31-15(2)18-11-29-22(30-12-18)24(25,26)27/h7-12,15H,4-6,13H2,1-3H3,(H,31,32)/t15-,23?/m1/s1 LFYNTNZWPQXJEM-NKTHEXPSSA-N 320162 3-[(2-methyltetrahydrofuran-2-yl)methoxy]-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide, as a mixture of two diastereoisomers::US10174016, Example 329::US10202369, Example 330::US10472354, Example 332 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320162 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320162&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397698 384223436 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625946 C[C@@H](NC(=O)c1cc(OC[C@@]2(C)CCCO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H25F3N4O3S/c1-14-10-28-21(35-14)17-7-16(8-19(9-17)33-13-23(3)5-4-6-34-23)20(32)31-15(2)18-11-29-22(30-12-18)24(25,26)27/h7-12,15H,4-6,13H2,1-3H3,(H,31,32)/t15-,23-/m1/s1 LFYNTNZWPQXJEM-IQMFZBJNSA-N 320163 3-[(2-methyltetrahydrofuran-2-yl)methoxy]-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 330::US10472354, Example 334 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320163 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320163&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 138374909 384223437 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625948 C[C@@H](NC(=O)c1cc(OC[C@]2(C)CCCO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H25F3N4O3S/c1-14-10-28-21(35-14)17-7-16(8-19(9-17)33-13-23(3)5-4-6-34-23)20(32)31-15(2)18-11-29-22(30-12-18)24(25,26)27/h7-12,15H,4-6,13H2,1-3H3,(H,31,32)/t15-,23+/m1/s1 LFYNTNZWPQXJEM-CMJOXMDJSA-N 320164 US10174016, Example 331::US10472354, Example 333 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320164 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320164&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 138374910 384223438 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625950 C[C@@H](NC(=O)c1cc(OCC2(C)CCOC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H25F3N4O3S/c1-14-9-28-21(35-14)17-6-16(7-19(8-17)34-13-23(3)4-5-33-12-23)20(32)31-15(2)18-10-29-22(30-11-18)24(25,26)27/h6-11,15H,4-5,12-13H2,1-3H3,(H,31,32)/t15-,23?/m1/s1 FUZHKJYNGBDBHI-NKTHEXPSSA-N 320165 3-[(3-methyltetrahydrofuran-3-yl)methoxy]-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide, as a Mixture of Two Diastereoisomers::US10174016, Example 332::US10202369, Example 333 P2X purinoceptor 3 Homo sapiens 4.00 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320165 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320165&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397763 384223439 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625952 C[C@@H](NC(=O)c1cc(OC[C@@]2(C)CCOC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H25F3N4O3S/c1-14-9-28-21(35-14)17-6-16(7-19(8-17)34-13-23(3)4-5-33-12-23)20(32)31-15(2)18-10-29-22(30-11-18)24(25,26)27/h6-11,15H,4-5,12-13H2,1-3H3,(H,31,32)/t15-,23+/m1/s1 FUZHKJYNGBDBHI-CMJOXMDJSA-N 320166 3-[(3-methyltetrahydrofuran-3-yl)methoxy]-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 333 P2X purinoceptor 3 Homo sapiens 4.00 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320166 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320166&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 138374911 384223440 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625954 C[C@@H](NC(=O)c1cc(OC[C@]2(C)CCOC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H25F3N4O3S/c1-14-9-28-21(35-14)17-6-16(7-19(8-17)34-13-23(3)4-5-33-12-23)20(32)31-15(2)18-10-29-22(30-11-18)24(25,26)27/h6-11,15H,4-5,12-13H2,1-3H3,(H,31,32)/t15-,23-/m1/s1 FUZHKJYNGBDBHI-IQMFZBJNSA-N 320167 US10174016, Example 334 P2X purinoceptor 3 Homo sapiens 4.00 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320167 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320167&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 138374912 384223441 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625956 C[C@@H](NC(=O)c1cc(OC2CCC(=O)N(C)C2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H24F3N5O3S/c1-13-9-28-22(36-13)16-6-15(7-19(8-16)35-18-4-5-20(33)32(3)12-18)21(34)31-14(2)17-10-29-23(30-11-17)24(25,26)27/h6-11,14,18H,4-5,12H2,1-3H3,(H,31,34)/t14-,18?/m1/s1 CGMVCPWOPCCFBE-IKJXHCRLSA-N 320168 3-[(1-methyl-6-oxopiperidin-3-yl)oxy]-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide, as a mixture of two diastereoisomers::US10174016, Example 335::US10202369, Example 336::US10472354, Example 335 P2X purinoceptor 3 Homo sapiens 13.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320168 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320168&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397147 384223442 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625958 C[C@@H](NC(=O)c1cc(O[C@@H]2CCC(=O)N(C)C2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H24F3N5O3S/c1-13-9-28-22(36-13)16-6-15(7-19(8-16)35-18-4-5-20(33)32(3)12-18)21(34)31-14(2)17-10-29-23(30-11-17)24(25,26)27/h6-11,14,18H,4-5,12H2,1-3H3,(H,31,34)/t14-,18-/m1/s1 CGMVCPWOPCCFBE-RDTXWAMCSA-N 320169 3-[(1-methyl-6-oxopiperidin-3-yl)oxy]-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 336::US10472354, Example 336 P2X purinoceptor 3 Homo sapiens 14.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320169 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320169&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 138374913 384223443 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625960 C[C@@H](NC(=O)c1cc(O[C@H]2CCC(=O)N(C)C2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H24F3N5O3S/c1-13-9-28-22(36-13)16-6-15(7-19(8-16)35-18-4-5-20(33)32(3)12-18)21(34)31-14(2)17-10-29-23(30-11-17)24(25,26)27/h6-11,14,18H,4-5,12H2,1-3H3,(H,31,34)/t14-,18+/m1/s1 CGMVCPWOPCCFBE-KDOFPFPSSA-N 320170 US10174016, Example 337::US10472354, Example 337 P2X purinoceptor 3 Homo sapiens 13.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320170 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320170&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 138374914 384223444 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625962 CC(O)C(C)Oc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C22H23F3N4O3S/c1-11-8-26-20(33-11)16-5-15(6-18(7-16)32-14(4)13(3)30)19(31)29-12(2)17-9-27-21(28-10-17)22(23,24)25/h5-10,12-14,30H,1-4H3,(H,29,31)/t12-,13?,14?/m1/s1 FSGDRFBLPAILDE-IYXRBSQSSA-N 319995 3-{[3-hydroxybutan-2-yl]oxy}-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 162::US10174016, Example 338::US10202369, Example 339::US10472354, Example 338 P2X purinoceptor 3 Homo sapiens 4.00 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319995 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319995&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397269 384223275 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625964 CC(O)[C@H](C)Oc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C22H23F3N4O3S/c1-11-8-26-20(33-11)16-5-15(6-18(7-16)32-14(4)13(3)30)19(31)29-12(2)17-9-27-21(28-10-17)22(23,24)25/h5-10,12-14,30H,1-4H3,(H,29,31)/t12-,13?,14+/m1/s1 FSGDRFBLPAILDE-YIOYIWSBSA-N 320172 3-[(3-hydroxybutan-2-yl)oxy]-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 339::US10472354, Example 339 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320172 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320172&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 138374915 384223445 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625966 CC(O)[C@@H](C)Oc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C22H23F3N4O3S/c1-11-8-26-20(33-11)16-5-15(6-18(7-16)32-14(4)13(3)30)19(31)29-12(2)17-9-27-21(28-10-17)22(23,24)25/h5-10,12-14,30H,1-4H3,(H,29,31)/t12-,13?,14-/m1/s1 FSGDRFBLPAILDE-WYAMFQBQSA-N 320173 US10174016, Example 340::US10472354, Example 340 P2X purinoceptor 3 Homo sapiens 3.00 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320173 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320173&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 138374916 384223446 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625968 C[C@@H](NC(=O)c1cc(OC2C3COCC2CN(C)C3)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C26H28F3N5O3S/c1-14-7-30-24(38-14)17-4-16(23(35)33-15(2)18-8-31-25(32-9-18)26(27,28)29)5-21(6-17)37-22-19-10-34(3)11-20(22)13-36-12-19/h4-9,15,19-20,22H,10-13H2,1-3H3,(H,33,35)/t15-,19?,20?,22?/m1/s1 UOQSAFNLRPUQCS-DSXPMEPHSA-N 320174 3-[(7-methyl-3-oxa-7-azabicyclo[3.3.1]non-9-yl)oxy]-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide, as a Mixture of Two Stereoisomers::US10174016, Example 341::US10202369, Example 342::US10472354, Example 343 P2X purinoceptor 3 Homo sapiens 41.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320174 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320174&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397140 384223447 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625970 C[C@@H](NC(=O)c1cc(OC2C3COCC2CN(C)C3)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C26H28F3N5O3S/c1-14-7-30-24(38-14)17-4-16(23(35)33-15(2)18-8-31-25(32-9-18)26(27,28)29)5-21(6-17)37-22-19-10-34(3)11-20(22)13-36-12-19/h4-9,15,19-20,22H,10-13H2,1-3H3,(H,33,35)/t15-,19?,20?,22?/m1/s1 UOQSAFNLRPUQCS-DSXPMEPHSA-N 320175 3-[(7-methyl-3-oxa-7-azabicyclo[3.3.1]non-9-yl)oxy]-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 342 P2X purinoceptor 3 Homo sapiens 40.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320175 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320175&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397140 384223448 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625972 C[C@H](NC(=O)c1cc(OC2C3COCC2CN(C)C3)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C26H28F3N5O3S/c1-14-7-30-24(38-14)17-4-16(23(35)33-15(2)18-8-31-25(32-9-18)26(27,28)29)5-21(6-17)37-22-19-10-34(3)11-20(22)13-36-12-19/h4-9,15,19-20,22H,10-13H2,1-3H3,(H,33,35)/t15-,19?,20?,22?/m0/s1 UOQSAFNLRPUQCS-LONTXVJRSA-N 320176 US10174016, Example 343::US10202369, Example 343 P2X purinoceptor 3 Homo sapiens 135 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320176 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320176&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 138374917 384223449 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625974 CC(C)N1CC2COCC(C1)C2Oc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C28H32F3N5O3S/c1-15(2)36-11-21-13-38-14-22(12-36)24(21)39-23-6-18(5-19(7-23)26-32-8-16(3)40-26)25(37)35-17(4)20-9-33-27(34-10-20)28(29,30)31/h5-10,15,17,21-22,24H,11-14H2,1-4H3,(H,35,37)/t17-,21?,22?,24?/m1/s1 IQKMSJWJAJKSIQ-CBDSMJNHSA-N 320177 3-[(7-isopropyl-3-oxa-7-azabicyclo[3.3.1]non-9-yl)oxy]-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide, as a mixture of two stereoisomers::US10174016, Example 344::US10202369, Example 344::US10472354, Example 344 P2X purinoceptor 3 Homo sapiens 34.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320177 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320177&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397285 384223450 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625976 COC(=O)N1CC2COCC(C1)C2Oc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C27H28F3N5O5S/c1-14-7-31-24(41-14)17-4-16(23(36)34-15(2)18-8-32-25(33-9-18)27(28,29)30)5-21(6-17)40-22-19-10-35(26(37)38-3)11-20(22)13-39-12-19/h4-9,15,19-20,22H,10-13H2,1-3H3,(H,34,36)/t15-,19?,20?,22?/m1/s1 GHSFQGHMPBJNHK-DSXPMEPHSA-N 320178 US10174016, Example 345::US10202369, Example 345::methyl 9-[3-(5-methyl-1,3-thiazol-2-yl)-5-({(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}carbamoyl)phenoxy]-3-oxa-7-azabicycle[3.3.1]nonane-7-carboxylate, as a mixture of two stereoisomers P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320178 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320178&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397363 384223451 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625978 C[C@@H](NC(=O)c1cc(OC[C@H]2CN(CCO2)C(=O)OC(C)(C)C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C28H32F3N5O5S/c1-16-11-32-24(42-16)19-8-18(23(37)35-17(2)20-12-33-25(34-13-20)28(29,30)31)9-21(10-19)40-15-22-14-36(6-7-39-22)26(38)41-27(3,4)5/h8-13,17,22H,6-7,14-15H2,1-5H3,(H,35,37)/t17-,22-/m1/s1 OEKUZTDVCYAZBS-VGOFRKELSA-N 320179 Tert-butyl (2R)-2-{[3-(5-methyl-1,3-thiazol-2-yl)-5-({(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}carbamoyl)phenoxy]methyl}morpholine-4-carboxylate::US10174016, Example 346::US10202369, Example 346::US10472354, Example 346 P2X purinoceptor 3 Homo sapiens 13.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320179 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320179&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134338449 384223452 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625980 C[C@@H](NC(=O)c1cc(OC[C@H]2CNCCO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H24F3N5O3S/c1-13-8-28-21(35-13)16-5-15(6-18(7-16)34-12-19-11-27-3-4-33-19)20(32)31-14(2)17-9-29-22(30-10-17)23(24,25)26/h5-10,14,19,27H,3-4,11-12H2,1-2H3,(H,31,32)/t14-,19-/m1/s1 HRVUBTPQOQIHTK-AUUYWEPGSA-N 320180 3-(5-Methyl-1,3-thiazol-2-yl)-5-[(2R)-morpholin-2-ylmethoxy]-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 347::US10202369, Example 347::US10472354, Example 347 P2X purinoceptor 3 Homo sapiens 9.00 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320180 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320180&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397601 384223453 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625982 C[C@@H](NC(=O)c1cc(OC[C@H]2CN(C)CCO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H26F3N5O3S/c1-14-9-28-22(36-14)17-6-16(7-19(8-17)35-13-20-12-32(3)4-5-34-20)21(33)31-15(2)18-10-29-23(30-11-18)24(25,26)27/h6-11,15,20H,4-5,12-13H2,1-3H3,(H,31,33)/t15-,20-/m1/s1 MROBUJILSMBILX-FOIQADDNSA-N 320181 3-{[(2R)-4-methylmorpholin-2-yl]methoxy}-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 348::US10202369, Example 348::US10472354, Example 348 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320181 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320181&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397607 384223454 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625984 C[C@@H](NC(=O)c1cc(OC[C@@H]2CN(CCO2)C(=O)OC(C)(C)C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C28H32F3N5O5S/c1-16-11-32-24(42-16)19-8-18(23(37)35-17(2)20-12-33-25(34-13-20)28(29,30)31)9-21(10-19)40-15-22-14-36(6-7-39-22)26(38)41-27(3,4)5/h8-13,17,22H,6-7,14-15H2,1-5H3,(H,35,37)/t17-,22+/m1/s1 OEKUZTDVCYAZBS-VGSWGCGISA-N 320182 Tert-butyl (2S)-2-{[3-(5-methyl-1,3-thiazol-2-yl)-5-({(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}carbamoyl)phenoxy]methyl}morpholine-4-carboxylate::US10174016, Example 349::US10202369, Example 349::US10472354, Example 349 P2X purinoceptor 3 Homo sapiens 23.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320182 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320182&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134338450 384223455 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625986 C[C@@H](NC(=O)c1cc(OC[C@@H]2CNCCO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H24F3N5O3S/c1-13-8-28-21(35-13)16-5-15(6-18(7-16)34-12-19-11-27-3-4-33-19)20(32)31-14(2)17-9-29-22(30-10-17)23(24,25)26/h5-10,14,19,27H,3-4,11-12H2,1-2H3,(H,31,32)/t14-,19+/m1/s1 HRVUBTPQOQIHTK-KUHUBIRLSA-N 320183 3-(5-Methyl-1,3-thiazol-2-yl)-5-[(2S)-morpholin-2-ylmethoxy]-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 350::US10202369, Example 350::US10472354, Example 350 P2X purinoceptor 3 Homo sapiens 14.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320183 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320183&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397343 384223456 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625988 C[C@@H](NC(=O)c1cc(OC[C@@H]2CN(C)CCO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H26F3N5O3S/c1-14-9-28-22(36-14)17-6-16(7-19(8-17)35-13-20-12-32(3)4-5-34-20)21(33)31-15(2)18-10-29-23(30-11-18)24(25,26)27/h6-11,15,20H,4-5,12-13H2,1-3H3,(H,31,33)/t15-,20+/m1/s1 MROBUJILSMBILX-QRWLVFNGSA-N 320184 3-{[(2S)-4-methylmorpholin-2-yl]methoxy}-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 351::US10202369, Example 351::US10472354, Example 351 P2X purinoceptor 3 Homo sapiens 16.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320184 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320184&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397379 384223457 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625990 C[C@@H](NC(=O)c1cc(OCC2CNCCO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H24F3N5O3S/c1-13-8-28-21(35-13)16-5-15(6-18(7-16)34-12-19-11-27-3-4-33-19)20(32)31-14(2)17-9-29-22(30-10-17)23(24,25)26/h5-10,14,19,27H,3-4,11-12H2,1-2H3,(H,31,32)/t14-,19?/m1/s1 HRVUBTPQOQIHTK-MJTSIZKDSA-N 320185 3-(5-Methyl-1,3-thiazol-2-yl)-5-[morpholin-2-ylmethoxy]-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide, Formed as a Mixture of Example 347 (Diastereoisomer 1) and Example 350 (Diastereoisomer 2)::US10174016, Example 352::US10202369, Example 352::US10472354, Example 352 P2X purinoceptor 3 Homo sapiens 18.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320185 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320185&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397625 384223458 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625992 C[C@@H](NC(=O)c1cc(OCC2CN(C)CCO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H26F3N5O3S/c1-14-9-28-22(36-14)17-6-16(7-19(8-17)35-13-20-12-32(3)4-5-34-20)21(33)31-15(2)18-10-29-23(30-11-18)24(25,26)27/h6-11,15,20H,4-5,12-13H2,1-3H3,(H,31,33)/t15-,20?/m1/s1 MROBUJILSMBILX-IWPPFLRJSA-N 320186 3-{[4-methylmorpholin-2-yl]methoxy}-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide, formed as a mixture of Example 348 (Diastereoisomer 2) and Example 351 (Diastereoisomer 1)::US10174016, Example 353::US10202369, Example 353::US10472354, Example 353 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320186 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320186&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397299 384223459 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625994 C[C@@H](NC(=O)c1cc(OC[C@@]2(F)CCCNC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H25F4N5O2S/c1-14-9-30-21(36-14)17-6-16(7-19(8-17)35-13-23(25)4-3-5-29-12-23)20(34)33-15(2)18-10-31-22(32-11-18)24(26,27)28/h6-11,15,29H,3-5,12-13H2,1-2H3,(H,33,34)/t15-,23-/m1/s1 KEYDTZMORFCFGJ-IQMFZBJNSA-N 320187 3-(Fluoropiperidin-3-yl)methoxyl}-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 354::US10472354, Example 354 P2X purinoceptor 3 Homo sapiens 25.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320187 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320187&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 138374918 384223460 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625996 C[C@@H](NC(=O)c1cc(OC[C@]2(F)CCCNC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H25F4N5O2S/c1-14-9-30-21(36-14)17-6-16(7-19(8-17)35-13-23(25)4-3-5-29-12-23)20(34)33-15(2)18-10-31-22(32-11-18)24(26,27)28/h6-11,15,29H,3-5,12-13H2,1-2H3,(H,33,34)/t15-,23+/m1/s1 KEYDTZMORFCFGJ-CMJOXMDJSA-N 320188 US10174016, Example 355::US10472354, Example 355 P2X purinoceptor 3 Homo sapiens 9.00 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320188 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320188&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 138374919 384223461 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 625998 C[C@@H](NC(=O)c1cc(OC[C@@]2(F)CCCN(C)C2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C25H27F4N5O2S/c1-15-10-30-22(37-15)18-7-17(8-20(9-18)36-14-24(26)5-4-6-34(3)13-24)21(35)33-16(2)19-11-31-23(32-12-19)25(27,28)29/h7-12,16H,4-6,13-14H2,1-3H3,(H,33,35)/t16-,24-/m1/s1 JEEGJUGZAOELQB-VOIUYBSRSA-N 320189 3-{[3-fluoro-1-methylpiperidin-3-yl]methoxy}-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 356::US10472354, Example 356 P2X purinoceptor 3 Homo sapiens 29.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320189 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320189&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 138374920 384223462 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 626000 C[C@@H](NC(=O)c1cc(OC[C@]2(F)CCCN(C)C2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C25H27F4N5O2S/c1-15-10-30-22(37-15)18-7-17(8-20(9-18)36-14-24(26)5-4-6-34(3)13-24)21(35)33-16(2)19-11-31-23(32-12-19)25(27,28)29/h7-12,16H,4-6,13-14H2,1-3H3,(H,33,35)/t16-,24+/m1/s1 JEEGJUGZAOELQB-GYCJOSAFSA-N 320190 US10174016, Example 357::US10472354, Example 357 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320190 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320190&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 138374921 384223463 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 626002 C[C@@H](NC(=O)c1cc(OCC2(F)CNC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C22H21F4N5O2S/c1-12-6-28-19(34-12)15-3-14(4-17(5-15)33-11-21(23)9-27-10-21)18(32)31-13(2)16-7-29-20(30-8-16)22(24,25)26/h3-8,13,27H,9-11H2,1-2H3,(H,31,32)/t13-/m1/s1 BCJGFEUMNVQMPR-CYBMUJFWSA-N 320191 3-[(3- fluoroazetidin- 3-yl)methoxy]- 5-(5-methyl- 1,3-thiazol-2- yl)-N-{(1R)-1- [2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 358::US10202369, Example 358::US10472354, Example 358 P2X purinoceptor 3 Homo sapiens 57.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320191 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320191&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397395 384223464 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 626004 C[C@@H](NC(=O)c1cc(OCC2CNCCC2(F)F)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H24F5N5O2S/c1-13-8-31-21(37-13)16-5-15(6-19(7-16)36-12-18-11-30-4-3-23(18,25)26)20(35)34-14(2)17-9-32-22(33-10-17)24(27,28)29/h5-10,14,18,30H,3-4,11-12H2,1-2H3,(H,34,35)/t14-,18?/m1/s1 GMFUIUUSPXQCGC-IKJXHCRLSA-N 320192 3-{[4,4- difluoropiperidin- 3- yl]methoxy}-5- (5-methyl-1,3- thiazol-2-yl)- N-{(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide, as a mixture of 2 diastereoisomers::US10174016, Example 359::US10202369, Example 359::US10472354, Example 359 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320192 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320192&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397568 384223465 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 626006 C[C@@H](NC(=O)c1cc(OC[C@H]2COCCN2C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H26F3N5O3S/c1-14-9-28-22(36-14)17-6-16(7-20(8-17)35-13-19-12-34-5-4-32(19)3)21(33)31-15(2)18-10-29-23(30-11-18)24(25,26)27/h6-11,15,19H,4-5,12-13H2,1-3H3,(H,31,33)/t15-,19-/m1/s1 QQIYVSYWBHUFSE-DNVCBOLYSA-N 320193 3-{[(3R)-4-methylmorpholin-3-yl]methoxyl}-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 360::US10202369, Example 360::US10472354, Example 360 P2X purinoceptor 3 Homo sapiens 10.00 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320193 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320193&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397664 384223466 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 626008 C[C@@H](NC(=O)c1cc(OC[C@@H]2COCCN2C)cc(c1)-c1ncc(C)s1)c1ccc(nc1)C(F)(F)F InChI=1S/C25H27F3N4O3S/c1-15-11-30-24(36-15)19-8-18(9-21(10-19)35-14-20-13-34-7-6-32(20)3)23(33)31-16(2)17-4-5-22(29-12-17)25(26,27)28/h4-5,8-12,16,20H,6-7,13-14H2,1-3H3,(H,31,33)/t16-,20+/m1/s1 VDLXIDIXMUFWTI-UZLBHIALSA-N 320194 3-{[(3S)-4- methylmorpholin- 3- yl]methoxy}-5- (5-methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[6- (trifluoromethyl) pyridin-3- yl]ethyl} benzamide::US10174016, Example 361::US10202369, Example 361::US10472354, Example 361 P2X purinoceptor 3 Homo sapiens 14.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320194 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320194&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397445 384223467 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 626010 C[C@@H](NC(=O)c1cc(OC[C@@H]2COCCN2C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H26F3N5O3S/c1-14-9-28-22(36-14)17-6-16(7-20(8-17)35-13-19-12-34-5-4-32(19)3)21(33)31-15(2)18-10-29-23(30-11-18)24(25,26)27/h6-11,15,19H,4-5,12-13H2,1-3H3,(H,31,33)/t15-,19+/m1/s1 QQIYVSYWBHUFSE-BEFAXECRSA-N 320195 3-{[(3S)-4- methylmorpholin- 3- yl]methoxy}-5- (5-methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyridin-5- yl]ethyl} benzamide::US10174016, Example 362::US10202369, Example 362::US10472354, Example 362 P2X purinoceptor 3 Homo sapiens 8.00 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320195 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320195&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397415 384223468 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 626012 C[C@@H](NC(=O)c1cc(OC[C@H]2COCCN2C)cc(c1)-c1ncc(C)s1)c1ccc(nc1)C(F)(F)F InChI=1S/C25H27F3N4O3S/c1-15-11-30-24(36-15)19-8-18(9-21(10-19)35-14-20-13-34-7-6-32(20)3)23(33)31-16(2)17-4-5-22(29-12-17)25(26,27)28/h4-5,8-12,16,20H,6-7,13-14H2,1-3H3,(H,31,33)/t16-,20-/m1/s1 VDLXIDIXMUFWTI-OXQOHEQNSA-N 320196 3-{[(3R)-4- methylmorpholin- 3- yl]methoxy}-5- (5-methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[6- (trifluoromethyl) pyridin-3- yl]ethyl} benzamide::US10174016, Example 363::US10472354, Example 363 P2X purinoceptor 3 Homo sapiens 12.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320196 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320196&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397368 384223469 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 626014 C[C@@H](NC(=O)c1cc(OCC2CC(F)CN2C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H25F4N5O2S/c1-13-8-29-22(36-13)16-4-15(5-20(6-16)35-12-19-7-18(25)11-33(19)3)21(34)32-14(2)17-9-30-23(31-10-17)24(26,27)28/h4-6,8-10,14,18-19H,7,11-12H2,1-3H3,(H,32,34)/t14-,18?,19?/m1/s1 UCQIVXMFKURDDU-FTXHTYHOSA-N 320197 3-{[4-fluoro-1- methylpyrrolidin- 2- yl]methoxy}-5- (5-methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide, as a mixture of stereoisomers::US10174016, Example 364::US10202369, Example 364::US10472354, Example 364 P2X purinoceptor 3 Homo sapiens 16.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320197 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320197&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397240 384223470 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 626016 C[C@@H](NC(=O)c1cc(OCC2CC(F)CN2C)cc(c1)-c1ncc(C)s1)c1ccc(nc1)C(F)(F)F InChI=1S/C25H26F4N4O2S/c1-14-10-31-24(36-14)18-6-17(7-21(8-18)35-13-20-9-19(26)12-33(20)3)23(34)32-15(2)16-4-5-22(30-11-16)25(27,28)29/h4-8,10-11,15,19-20H,9,12-13H2,1-3H3,(H,32,34)/t15-,19?,20?/m1/s1 XNRRWTQJTXNPEU-APMMTJHUSA-N 320198 3-{[4-fluoro-1- methylpyrrolidin- 2- yl]methoxy}-5- (5-methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[6- (trifluoromethyl) pyridin-3- yl]ethyl} benzamide, as a mixture of stereoisomers::US10174016, Example 365::US10202369, Example 365::US10472354, Example 365 P2X purinoceptor 3 Homo sapiens 21.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320198 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320198&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397581 384223471 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 626018 C[C@@H](NC(=O)c1cc(OC[C@H]2CN(C)CCO2)cc(c1)-c1ncc(C)s1)c1ccc(nc1)C(F)(F)F InChI=1S/C25H27F3N4O3S/c1-15-11-30-24(36-15)19-8-18(9-20(10-19)35-14-21-13-32(3)6-7-34-21)23(33)31-16(2)17-4-5-22(29-12-17)25(26,27)28/h4-5,8-12,16,21H,6-7,13-14H2,1-3H3,(H,31,33)/t16-,21-/m1/s1 PQZKBUDIGDWISA-IIBYNOLFSA-N 320199 3-{[(2R)-4-methylmorpholin-2-yl]methoxyl}-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[6-(trifluoromethyl)pyridin-3-yl]ethyl}benzamide::US10174016, Example 366::US10202369, Example 366::US10472354, Example 366 P2X purinoceptor 3 Homo sapiens 18.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320199 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320199&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397655 384223472 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 626020 C[C@@H](NC(=O)c1cc(OC[C@H]2CN(C)CCO2)cc(c1)-c1ncc(Cl)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H23ClF3N5O3S/c1-13(16-8-29-22(30-9-16)23(25,26)27)31-20(33)14-5-15(21-28-10-19(24)36-21)7-17(6-14)35-12-18-11-32(2)3-4-34-18/h5-10,13,18H,3-4,11-12H2,1-2H3,(H,31,33)/t13-,18-/m1/s1 AJIHXKQJGQMCEX-FZKQIMNGSA-N 320200 3-(5-chloro- 1,3-thiazol-2- yl)-5-{[(2R)-4- methylmorpholin- 2-yl]methoxy}-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5-yl] ethyl}benzamide::US10174016, Example 367::US10202369, Example 367::US10472354, Example 367 P2X purinoceptor 3 Homo sapiens 13.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320200 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320200&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397149 384223473 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 626022 CN1CCO[C@H](COc2cc(cc(c2)-c2ncc(C)s2)C(=O)NCc2cnc(nc2)C(F)(F)F)C1 InChI=1S/C23H24F3N5O3S/c1-14-8-28-21(35-14)17-5-16(6-18(7-17)34-13-19-12-31(2)3-4-33-19)20(32)27-9-15-10-29-22(30-11-15)23(24,25)26/h5-8,10-11,19H,3-4,9,12-13H2,1-2H3,(H,27,32)/t19-/m0/s1 VTYFKUULJMRVCQ-IBGZPJMESA-N 320201 3-{[(2S)-4- methylmorpholin- 2-yl]methoxy}-5- (5-methyl-1,3- thiazol-2-yl)- N-{[2- (trifluoromethyl) pyrimidin-5-yl] methyl} benzamide::US10174016, Example 368::US10202369, Example 368::US10472354, Example 368 P2X purinoceptor 3 Homo sapiens 84.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320201 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320201&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397462 384223474 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 626024 C[C@@H](NC(=O)c1cc(OC[C@H]2CN(C)CCO2)cc(c1)-c1ncc(C)s1)c1ccc(nc1)C(F)F InChI=1S/C25H28F2N4O3S/c1-15-11-29-25(35-15)19-8-18(9-20(10-19)34-14-21-13-31(3)6-7-33-21)24(32)30-16(2)17-4-5-22(23(26)27)28-12-17/h4-5,8-12,16,21,23H,6-7,13-14H2,1-3H3,(H,30,32)/t16-,21-/m1/s1 YEIOEBIHIRXRPN-IIBYNOLFSA-N 320202 N-{(1R)-1-[6- (difluoromethyl) pyridin-3- yl]ethyl}-3- {[(2R)-4- methylmorpholin- 2-yl]methoxy}-5- (5-methyl-1,3- thiazol-2- yl)benzamide::US10174016, Example 369::US10202369, Example 369::US10472354, Example 369 P2X purinoceptor 3 Homo sapiens 11.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320202 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320202&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397220 384223475 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 626026 C[C@@H](NC(=O)c1cc(OC[C@@H]2CN(C)CCO2)cc(c1)-c1ncc(C)s1)c1ccc(nc1)C(F)(F)F InChI=1S/C25H27F3N4O3S/c1-15-11-30-24(36-15)19-8-18(9-20(10-19)35-14-21-13-32(3)6-7-34-21)23(33)31-16(2)17-4-5-22(29-12-17)25(26,27)28/h4-5,8-12,16,21H,6-7,13-14H2,1-3H3,(H,31,33)/t16-,21+/m1/s1 PQZKBUDIGDWISA-IERDGZPVSA-N 320203 3-{[(2S)-4- methylmorpholin 2-yl]methoxy}-5- (5-methyl-1,3- thiazol-2-yl)- N-{(1R)-1-[6- (trifluoromethyl) pyridin-3- yl]ethyl} benzamide::US10174016, Example 370::US10202369, Example 370::US10472354, Example 370 P2X purinoceptor 3 Homo sapiens 41.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320203 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320203&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397778 384223476 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 626028 C[C@@H](NC(=O)c1cc(OCC2(F)CN(C)C2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H23F4N5O2S/c1-13-7-28-20(35-13)16-4-15(5-18(6-16)34-12-22(24)10-32(3)11-22)19(33)31-14(2)17-8-29-21(30-9-17)23(25,26)27/h4-9,14H,10-12H2,1-3H3,(H,31,33)/t14-/m1/s1 UHPSIXSPUGVYFA-CQSZACIVSA-N 320204 3-[(3-fluoro-1- methylazetidin-3- yl}methoxy]-5- (5-methyl-1,3- thiazol-2-yl)- N-{(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 371::US10202369, Example 371::US10472354, Example 371 P2X purinoceptor 3 Homo sapiens 24.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320204 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320204&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397234 384223477 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 626030 CN1CCO[C@@H](COc2cc(cc(c2)-c2ncc(C)s2)C(=O)NCc2cnc(nc2)C(F)(F)F)C1 InChI=1S/C23H24F3N5O3S/c1-14-8-28-21(35-14)17-5-16(6-18(7-17)34-13-19-12-31(2)3-4-33-19)20(32)27-9-15-10-29-22(30-11-15)23(24,25)26/h5-8,10-11,19H,3-4,9,12-13H2,1-2H3,(H,27,32)/t19-/m1/s1 VTYFKUULJMRVCQ-LJQANCHMSA-N 320205 3-{[(2R)-4- methylmorpholin- 2-yl]methoxy}-5- (5-methyl-1,3- thiazol-2-yl)- N-{[2- (trifluoromethyl) pyrimidin-5-yl] methyl} benzamide::US10174016, Example 372::US10202369, Example 372::US10472354, Example 372 P2X purinoceptor 3 Homo sapiens 19.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320205 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320205&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397797 384223478 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 626032 C[C@@H](NC(=O)c1cc(OC[C@H]2CN(C)CCO2)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F InChI=1S/C24H26F3N5O3S/c1-14-11-28-23(36-14)17-8-16(9-18(10-17)35-13-19-12-32(3)6-7-34-19)22(33)29-15(2)20-4-5-21(31-30-20)24(25,26)27/h4-5,8-11,15,19H,6-7,12-13H2,1-3H3,(H,29,33)/t15-,19-/m1/s1 IJFKDPNABTXGCF-DNVCBOLYSA-N 320206 3-{[(2R)-4- methylmorpholin- 2-yl]methoxy}-5- (5-methyl-1,3- thiazol-2-yl)- N-{(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl} benzamide::US10174016, Example 373::US10202369, Example 373::US10472354, Example 373 P2X purinoceptor 3 Homo sapiens 21.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320206 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320206&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397505 384223479 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 626034 C[C@@H](NC(=O)c1cc(OC[C@@H]2CN(C)CCO2)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F InChI=1S/C24H26F3N5O3S/c1-14-11-28-23(36-14)17-8-16(9-18(10-17)35-13-19-12-32(3)6-7-34-19)22(33)29-15(2)20-4-5-21(31-30-20)24(25,26)27/h4-5,8-11,15,19H,6-7,12-13H2,1-3H3,(H,29,33)/t15-,19+/m1/s1 IJFKDPNABTXGCF-BEFAXECRSA-N 320207 3-{[(2S)-4- methylmorpholin- 2-yl]methoxy}-5- (5-methyl-1,3- thiazol-2-yl)- N-{(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl} benzamide::US10174016, Example 374::US10202369, Example 374::US10472354, Example 374 P2X purinoceptor 3 Homo sapiens 55.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320207 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320207&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397406 384223480 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 626036 CCc1cnc(s1)-c1cc(OC[C@@H]2CN(C)CCO2)cc(c1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C25H28F3N5O3S/c1-4-21-12-29-23(37-21)17-7-16(8-19(9-17)36-14-20-13-33(3)5-6-35-20)22(34)32-15(2)18-10-30-24(31-11-18)25(26,27)28/h7-12,15,20H,4-6,13-14H2,1-3H3,(H,32,34)/t15-,20+/m1/s1 PEGAFCGSQABLTK-QRWLVFNGSA-N 320208 3-(5-ethyl-1,3- thiazol-2-yl)-5- {[(2S)-4- methylmorpholin- 2- yl]methoxy}-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 375::US10202369, Example 375::US10472354, Example 375 P2X purinoceptor 3 Homo sapiens 11.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320208 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320208&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397736 384223481 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 626038 C[C@@H](NC(=O)c1cc(OC[C@@H]2CN(C)CCO2)cc(c1)-c1ncc(Cl)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H23ClF3N5O3S/c1-13(16-8-29-22(30-9-16)23(25,26)27)31-20(33)14-5-15(21-28-10-19(24)36-21)7-17(6-14)35-12-18-11-32(2)3-4-34-18/h5-10,13,18H,3-4,11-12H2,1-2H3,(H,31,33)/t13-,18+/m1/s1 AJIHXKQJGQMCEX-ACJLOTCBSA-N 320209 3-(5-chloro- 1,3-thiazol-2- yl)-5-{[(2S)-4- methylmorpholin- 2-yl]methoxy}-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 376::US10202369, Example 376::US10472354, Example 376 P2X purinoceptor 3 Homo sapiens 32.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320209 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320209&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397674 384223482 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 626040 CCc1cnc(s1)-c1cc(OC[C@H]2CN(C)CCO2)cc(c1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C25H28F3N5O3S/c1-4-21-12-29-23(37-21)17-7-16(8-19(9-17)36-14-20-13-33(3)5-6-35-20)22(34)32-15(2)18-10-30-24(31-11-18)25(26,27)28/h7-12,15,20H,4-6,13-14H2,1-3H3,(H,32,34)/t15-,20-/m1/s1 PEGAFCGSQABLTK-FOIQADDNSA-N 320210 3-(5-ethyl-1,3- thiazol-2-yl)-5- {[(2R)-4- methylmorpholin- 2-yl]methoxy}-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 377::US10202369, Example 377::US10472354, Example 377 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320210 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320210&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397144 384223483 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 626042 C[C@@H](NC(=O)c1cc(OC[C@@H]2CCCN2C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H26F3N5O2S/c1-14-10-28-22(35-14)17-7-16(8-20(9-17)34-13-19-5-4-6-32(19)3)21(33)31-15(2)18-11-29-23(30-12-18)24(25,26)27/h7-12,15,19H,4-6,13H2,1-3H3,(H,31,33)/t15-,19+/m1/s1 TYUJHJGDOVFFQY-BEFAXECRSA-N 320211 3-{[(2S)-1- methylpyrrolidin- 2-yl]methoxy}-5- (5-methyl-1,3- thiazol-2-yl)- N-{(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 378::US10202369, Example 378::US10472354, Example 378 P2X purinoceptor 3 Homo sapiens 60.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320211 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320211&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397183 384223484 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 626044 C[C@@H](NC(=O)c1cc(OC[C@H]2CCCN2C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H26F3N5O2S/c1-14-10-28-22(35-14)17-7-16(8-20(9-17)34-13-19-5-4-6-32(19)3)21(33)31-15(2)18-11-29-23(30-12-18)24(25,26)27/h7-12,15,19H,4-6,13H2,1-3H3,(H,31,33)/t15-,19-/m1/s1 TYUJHJGDOVFFQY-DNVCBOLYSA-N 320212 3-{[(2R)-1- methylpyrrolidin- 2-yl]methoxy}-5 (5-methyl-1,3- thiazol-2-yl)- N-{(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 379::US10202369, Example 379::US10472354, Example 379 P2X purinoceptor 3 Homo sapiens 42.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320212 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320212&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397315 384223485 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 626046 C[C@@H](NC(=O)c1cc(OCC2CCN(C)CC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C25H28F3N5O2S/c1-15-11-29-23(36-15)19-8-18(9-21(10-19)35-14-17-4-6-33(3)7-5-17)22(34)32-16(2)20-12-30-24(31-13-20)25(26,27)28/h8-13,16-17H,4-7,14H2,1-3H3,(H,32,34)/t16-/m1/s1 GQMGTASPVLCRIR-MRXNPFEDSA-N 320213 3-[(1- methylpiperidin- 4-yl)methoxy]-5- (5-methyl-1,3- thiazol-2-yl)- N-{(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 380::US10202369, Example 380::US10472354, Example 380 P2X purinoceptor 3 Homo sapiens 32.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320213 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320213&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397264 384223486 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 626048 CC(C)N1CCO[C@@H](COc2cc(cc(c2)-c2ncc(C)s2)C(=O)N[C@H](C)c2cnc(nc2)C(F)(F)F)C1 InChI=1S/C26H30F3N5O3S/c1-15(2)34-5-6-36-22(13-34)14-37-21-8-18(7-19(9-21)24-30-10-16(3)38-24)23(35)33-17(4)20-11-31-25(32-12-20)26(27,28)29/h7-12,15,17,22H,5-6,13-14H2,1-4H3,(H,33,35)/t17-,22-/m1/s1 AOHBYHNFISDLHQ-VGOFRKELSA-N 320214 3-(5-methyl- 1,3-thiazol-2- yl)-5-{[(2R)-4- (propan-2- yl)morpholin- 2-yl]methoxy}- N-{(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 381::US10202369, Example 381::US10472354, Example 381 P2X purinoceptor 3 Homo sapiens 16.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320214 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320214&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397576 384223487 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 626050 CC(C)N1CCO[C@H](COc2cc(cc(c2)-c2ncc(C)s2)C(=O)N[C@H](C)c2cnc(nc2)C(F)(F)F)C1 InChI=1S/C26H30F3N5O3S/c1-15(2)34-5-6-36-22(13-34)14-37-21-8-18(7-19(9-21)24-30-10-16(3)38-24)23(35)33-17(4)20-11-31-25(32-12-20)26(27,28)29/h7-12,15,17,22H,5-6,13-14H2,1-4H3,(H,33,35)/t17-,22+/m1/s1 AOHBYHNFISDLHQ-VGSWGCGISA-N 320215 3-(5-methyl- 1,3-thiazol-2- yl)-5-{[(2R)-4- (propan-2- yl)morpholin- 2-yl]methoxy}- N-{(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 382::US10202369, Example 382::US10472354, Example 382 P2X purinoceptor 3 Homo sapiens 13.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320215 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320215&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397421 384223488 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 626052 C[C@@H](NC(=O)c1cc(OCC2CN(C)CCC2(F)F)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C25H26F5N5O2S/c1-14-9-31-22(38-14)17-6-16(7-20(8-17)37-13-19-12-35(3)5-4-24(19,26)27)21(36)34-15(2)18-10-32-23(33-11-18)25(28,29)30/h6-11,15,19H,4-5,12-13H2,1-3H3,(H,34,36)/t15-,19?/m1/s1 LGPVNMAGAZJDEW-NYRJJRHWSA-N 320216 3-{[4,4- difluoro-1- methylpiperidin- 3-yl]methoxy}-5- (5-methyl-1,3- thiazol-2-yl)- N-{(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide, as a mixture of 2 diastereoisomers::US10174016, Example 383::US10202369, Example 384::US10472354, Example 383 P2X purinoceptor 3 Homo sapiens 2.00 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320216 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320216&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397497 384223489 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 626054 C[C@@H](NC(=O)c1cc(OC[C@@H]2CN(C)CCC2(F)F)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C25H26F5N5O2S/c1-14-9-31-22(38-14)17-6-16(7-20(8-17)37-13-19-12-35(3)5-4-24(19,26)27)21(36)34-15(2)18-10-32-23(33-11-18)25(28,29)30/h6-11,15,19H,4-5,12-13H2,1-3H3,(H,34,36)/t15-,19+/m1/s1 LGPVNMAGAZJDEW-BEFAXECRSA-N 320217 3-{[4,4-difluoro-1-methylpiperidin-3-yl]methoxy}-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 384::US10174016, Example 385::US10472354, Example 385 P2X purinoceptor 3 Homo sapiens 3.00 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320217 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320217&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 138374922 384223490 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 626056 C[C@@H](NC(=O)c1cc(OC[C@@H]2CN(C)CCC2(F)F)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C25H26F5N5O2S/c1-14-9-31-22(38-14)17-6-16(7-20(8-17)37-13-19-12-35(3)5-4-24(19,26)27)21(36)34-15(2)18-10-32-23(33-11-18)25(28,29)30/h6-11,15,19H,4-5,12-13H2,1-3H3,(H,34,36)/t15-,19+/m1/s1 LGPVNMAGAZJDEW-BEFAXECRSA-N 320217 3-{[4,4-difluoro-1-methylpiperidin-3-yl]methoxy}-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 384::US10174016, Example 385::US10472354, Example 385 P2X purinoceptor 3 Homo sapiens 3.00 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320217 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320217&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 138374922 384223490 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 626058 C[C@@H](NC(=O)c1cc(OCC2(F)CN(C)C2)cc(c1)-c1ncc(C)s1)c1ccc(nc1)C(F)(F)F InChI=1S/C24H24F4N4O2S/c1-14-9-30-22(35-14)18-6-17(7-19(8-18)34-13-23(25)11-32(3)12-23)21(33)31-15(2)16-4-5-20(29-10-16)24(26,27)28/h4-10,15H,11-13H2,1-3H3,(H,31,33)/t15-/m1/s1 YWRAMSXXAJRPGK-OAHLLOKOSA-N 320219 3-[(3-fluoro-1- methylazetidin-3- yl)methoxy]-5-(5- methyl-1,3-thiazol- 2-yl)-N-{(1R)-1-[6- (trifluoromethyl) pyridin-3-yl] ethyl}benzamide::US10174016, Example 386::US10202369, Example 386::US10472354, Example 386 P2X purinoceptor 3 Homo sapiens 24.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320219 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320219&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397321 384223491 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 626060 CCc1cnc(s1)-c1cc(OCC2(F)CN(C)C2)cc(c1)C(=O)N[C@H](C)c1ccc(nc1)C(F)(F)F InChI=1S/C25H26F4N4O2S/c1-4-20-11-31-23(36-20)18-7-17(8-19(9-18)35-14-24(26)12-33(3)13-24)22(34)32-15(2)16-5-6-21(30-10-16)25(27,28)29/h5-11,15H,4,12-14H2,1-3H3,(H,32,34)/t15-/m1/s1 HCTVCZSENAWJEB-OAHLLOKOSA-N 320220 3-(5-ethyl-1,3- thiazol-2-yl)-5-[(3- fluoro-1- methylazetidin-3- yl)methoxy]-N- {(1R)-1-[6- (trifluoromethyl) pyridin-3-yl] ethyl}benzamide::US10174016, Example 387::US10202369, Example 387::US10472354, Example 387 P2X purinoceptor 3 Homo sapiens 19.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320220 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320220&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397751 384223492 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 626062 C[C@@H](NC(=O)c1cc(OC[C@H]2COCCN2C)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F InChI=1S/C24H26F3N5O3S/c1-14-11-28-23(36-14)17-8-16(9-19(10-17)35-13-18-12-34-7-6-32(18)3)22(33)29-15(2)20-4-5-21(31-30-20)24(25,26)27/h4-5,8-11,15,18H,6-7,12-13H2,1-3H3,(H,29,33)/t15-,18-/m1/s1 SOWWCICJAYGBSY-CRAIPNDOSA-N 320221 3-{[(3R)-4- methylmorpholin-3- yl]methoxy}-5-(5- methyl-1,3-thiazol- 2-yl)-N-{(1R)-1-[6- (trifluoromethyl) pyridazin-3-yl] ethyl}benzamide::US10174016, Example 388::US10202369, Example 388::US10472354, Example 388 P2X purinoceptor 3 Homo sapiens 18.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320221 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320221&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397768 384223493 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 626064 C[C@@H](NC(=O)c1cc(OC[C@@H]2COCCN2C)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F InChI=1S/C24H26F3N5O3S/c1-14-11-28-23(36-14)17-8-16(9-19(10-17)35-13-18-12-34-7-6-32(18)3)22(33)29-15(2)20-4-5-21(31-30-20)24(25,26)27/h4-5,8-11,15,18H,6-7,12-13H2,1-3H3,(H,29,33)/t15-,18+/m1/s1 SOWWCICJAYGBSY-QAPCUYQASA-N 320222 3-{[(3S)-4- methylmorpholin-3- yl]methoxy}-5-(5- methyl-1,3-thiazol- 2-yl)-N-{(1R)-1-[6- (trifluoromethyl) pyridazin-3-yl] ethyl}benzamide::US10174016, Example 389::US10202369, Example 389::US10472354, Example 389 P2X purinoceptor 3 Homo sapiens 18.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320222 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320222&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397449 384223494 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 626066 CCN1CCO[C@@H](COc2cc(cc(c2)-c2ncc(C)s2)C(=O)N[C@H](C)c2cnc(nc2)C(F)(F)F)C1 InChI=1S/C25H28F3N5O3S/c1-4-33-5-6-35-21(13-33)14-36-20-8-17(7-18(9-20)23-29-10-15(2)37-23)22(34)32-16(3)19-11-30-24(31-12-19)25(26,27)28/h7-12,16,21H,4-6,13-14H2,1-3H3,(H,32,34)/t16-,21-/m1/s1 IJXNJADLTIUKEL-IIBYNOLFSA-N 320223 3-{[(2R)-4-ethylmorpholin-2-yl]methoxy}-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 390::US10202369, Example 390::US10472354, Example 390 P2X purinoceptor 3 Homo sapiens 17.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320223 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320223&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397822 384223495 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 626068 C[C@@H](NC(=O)c1cc(OC[C@H]2CN(CC(F)F)CCO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C25H26F5N5O3S/c1-14-8-31-23(39-14)17-5-16(22(36)34-15(2)18-9-32-24(33-10-18)25(28,29)30)6-19(7-17)38-13-20-11-35(3-4-37-20)12-21(26)27/h5-10,15,20-21H,3-4,11-13H2,1-2H3,(H,34,36)/t15-,20-/m1/s1 LANXVVYUHZPONS-FOIQADDNSA-N 320224 3-{[(2R)-4-(2,2-difluoroethyl)morpholin-2-yl]methoxy}-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 391::US10202369, Example 391::US10472354, Example 391 P2X purinoceptor 3 Homo sapiens 19.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320224 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320224&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397746 384223496 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 626070 COC(=O)N1CCO[C@@H](COc2cc(cc(c2)-c2ncc(C)s2)C(=O)N[C@H](C)c2cnc(nc2)C(F)(F)F)C1 InChI=1S/C25H26F3N5O5S/c1-14-9-29-22(39-14)17-6-16(21(34)32-15(2)18-10-30-23(31-11-18)25(26,27)28)7-19(8-17)38-13-20-12-33(4-5-37-20)24(35)36-3/h6-11,15,20H,4-5,12-13H2,1-3H3,(H,32,34)/t15-,20-/m1/s1 AMNDVZJYNBRGRX-FOIQADDNSA-N 320225 Methyl (2R)-2-{[3-(5-methyl-1,3-thiazol-2-yl)-5-({(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}carbamoyl)phenoxy]methyl}morpholine-4-carboxylate::US10174016, Example 392::US10202369, Example 392::US10472354, Example 392 P2X purinoceptor 3 Homo sapiens 11.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320225 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320225&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134338451 384223497 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 626072 COC(=O)N1CCO[C@H](COc2cc(cc(c2)-c2ncc(C)s2)C(=O)N[C@H](C)c2cnc(nc2)C(F)(F)F)C1 InChI=1S/C25H26F3N5O5S/c1-14-9-29-22(39-14)17-6-16(21(34)32-15(2)18-10-30-23(31-11-18)25(26,27)28)7-19(8-17)38-13-20-12-33(4-5-37-20)24(35)36-3/h6-11,15,20H,4-5,12-13H2,1-3H3,(H,32,34)/t15-,20+/m1/s1 AMNDVZJYNBRGRX-QRWLVFNGSA-N 320226 Methyl (2S)-2- {[3-(5-methyl- 1,3-thiazol-2- yl)-5-({(1R)-1- [2- (trifluoromethyl) pyrimidin-5-yl] ethyl}carbamoyl) phenoxy]methyl} morpholine-4- carboxylate::US10174016, Example 393::US10202369, Example 393::US10472354, Example 393 P2X purinoceptor 3 Homo sapiens 24.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320226 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320226&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134338452 384223498 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 626074 C[C@@H](NC(=O)c1cc(OCC2CNC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C22H22F3N5O2S/c1-12-6-27-20(33-12)16-3-15(4-18(5-16)32-11-14-7-26-8-14)19(31)30-13(2)17-9-28-21(29-10-17)22(23,24)25/h3-6,9-10,13-14,26H,7-8,11H2,1-2H3,(H,30,31)/t13-/m1/s1 MHYFOJHMKOGSKR-CYBMUJFWSA-N 320227 3-(Azetidin-3-ylmethoxy)-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 394::US10202369, Example 394::US10472354, Example 394 P2X purinoceptor 3 Homo sapiens 82.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320227 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320227&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397376 384223499 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 626076 C[C@@H](NC(=O)c1cc(OC[C@H]2COCC(=O)N2C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H24F3N5O4S/c1-13-7-28-22(37-13)16-4-15(5-19(6-16)36-11-18-10-35-12-20(33)32(18)3)21(34)31-14(2)17-8-29-23(30-9-17)24(25,26)27/h4-9,14,18H,10-12H2,1-3H3,(H,31,34)/t14-,18-/m1/s1 SDFLFPYVVNTAIN-RDTXWAMCSA-N 320228 3-{[(3R)-4-methyl-5-oxomorpholin-3-yl]methoxyl}-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 395::US10202369, Example 395::US10472354, Example 395 P2X purinoceptor 3 Homo sapiens 30.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320228 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320228&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397767 384223500 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 626078 C[C@@H](NC(=O)c1cc(OC[C@H]2COCC(=O)N2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H22F3N5O4S/c1-12-6-27-21(36-12)15-3-14(4-18(5-15)35-10-17-9-34-11-19(32)31-17)20(33)30-13(2)16-7-28-22(29-8-16)23(24,25)26/h3-8,13,17H,9-11H2,1-2H3,(H,30,33)(H,31,32)/t13-,17-/m1/s1 QBCIMXIDQXCQLC-CXAGYDPISA-N 320229 3-(5-methyl-1,3- thiazol-2-yl)-5- {[(3R)-5- oxomorpholin-3- yl]methoxy}-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5-yl] ethyl}benzamide::US10174016, Example 396::US10202369, Example 396::US10472354, Example 396 P2X purinoceptor 3 Homo sapiens 22.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320229 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320229&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397733 384223501 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 626080 C[C@@H](NC(=O)c1cc(OC[C@@H]2CN(C)C(=O)O2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H22F3N5O4S/c1-12-7-27-20(36-12)15-4-14(5-17(6-15)34-11-18-10-31(3)22(33)35-18)19(32)30-13(2)16-8-28-21(29-9-16)23(24,25)26/h4-9,13,18H,10-11H2,1-3H3,(H,30,32)/t13-,18+/m1/s1 OAEQMLBAMDEFGR-ACJLOTCBSA-N 320230 3-{[(5S)-3-methyl-2- oxo-1,3-oxazolidin- 5-yl]methoxy}-5-(5- methyl-1,3-thiazol- 2-yl)-N-{(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 397::US10202369, Example 397::US10472354, Example 397 P2X purinoceptor 3 Homo sapiens 15.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320230 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320230&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397304 384223502 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 626082 C[C@@H](NC(=O)c1cc(OC[C@H]2CN(C)C(=O)O2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H22F3N5O4S/c1-12-7-27-20(36-12)15-4-14(5-17(6-15)34-11-18-10-31(3)22(33)35-18)19(32)30-13(2)16-8-28-21(29-9-16)23(24,25)26/h4-9,13,18H,10-11H2,1-3H3,(H,30,32)/t13-,18-/m1/s1 OAEQMLBAMDEFGR-FZKQIMNGSA-N 320231 3-{[(5R)-3-methyl-2- oxo-1,3-oxazolidin- 5-yl]methoxy}-5-(5- methyl-1,3-thiazol- 2-yl)-N-{(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 398::US10202369, Example 398::US10472354, Example 398 P2X purinoceptor 3 Homo sapiens 17.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320231 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320231&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397297 384223503 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 626084 C[C@@H](NC(=O)c1cc(OC[C@H]2CN(C)C(=O)CO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H24F3N5O4S/c1-13-7-28-22(37-13)16-4-15(5-18(6-16)35-11-19-10-32(3)20(33)12-36-19)21(34)31-14(2)17-8-29-23(30-9-17)24(25,26)27/h4-9,14,19H,10-12H2,1-3H3,(H,31,34)/t14-,19-/m1/s1 UCMZCPXWJACEJN-AUUYWEPGSA-N 320232 3-{[(2R)-4-methyl-5- oxomorpholin-2-yl] methoxy}-5-(5- methyl-1,3-thiazol- 2-yl)-N-{(1R)-1-[2- (trifluoromethyl) pyrimidin-5-yl] ethyl}benzamide::US10174016, Example 399::US10202369, Example 399::US10472354, Example 399 P2X purinoceptor 3 Homo sapiens 69.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320232 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320232&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397565 384223504 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 626086 C[C@@H](NC(=O)c1cc(OC[C@@H]2CNC(=O)CO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H22F3N5O4S/c1-12-6-28-21(36-12)15-3-14(4-17(5-15)34-10-18-9-27-19(32)11-35-18)20(33)31-13(2)16-7-29-22(30-8-16)23(24,25)26/h3-8,13,18H,9-11H2,1-2H3,(H,27,32)(H,31,33)/t13-,18+/m1/s1 SQKDWNUUISQXQF-ACJLOTCBSA-N 320233 3-(5-methyl-1,3- thiazol-2-yl)-5- {[(2S)-5- oxomorpholin-2- yl]methoxy}-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 400::US10202369, Example 400::US10472354, Example 400 P2X purinoceptor 3 Homo sapiens 59.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320233 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320233&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397173 384223505 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 626088 C[C@@H](NC(=O)c1cc(OC[C@@H]2CN(C)C(=O)CO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H24F3N5O4S/c1-13-7-28-22(37-13)16-4-15(5-18(6-16)35-11-19-10-32(3)20(33)12-36-19)21(34)31-14(2)17-8-29-23(30-9-17)24(25,26)27/h4-9,14,19H,10-12H2,1-3H3,(H,31,34)/t14-,19+/m1/s1 UCMZCPXWJACEJN-KUHUBIRLSA-N 320234 3-{[(2S)-4-methyl-5- oxomorpholin-2-yl] methoxy}-5-(5- methyl-1,3-thiazol- 2-yl)-N-{(1R)-1-[2- (trifluoromethyl) pyrimidin-5-yl] ethyl}benzamide::US10174016, Example 401::US10202369, Example 401::US10472354, Example 401 P2X purinoceptor 3 Homo sapiens 30.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320234 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320234&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397710 384223506 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 626090 C[C@@H](NC(=O)c1cc(OC[C@@H]2COCC(=O)N2C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H24F3N5O4S/c1-13-7-28-22(37-13)16-4-15(5-19(6-16)36-11-18-10-35-12-20(33)32(18)3)21(34)31-14(2)17-8-29-23(30-9-17)24(25,26)27/h4-9,14,18H,10-12H2,1-3H3,(H,31,34)/t14-,18+/m1/s1 SDFLFPYVVNTAIN-KDOFPFPSSA-N 320235 3-{[(3S)-4-methyl-5- oxomorpholin-3-yl] methoxy}-5-(5- methyl-1,3-thiazol- 2-yl)-N-{(1R)-1-[2- (trifluoromethyl) pyrimidin-5-yl] ethyl}benzamide::US10174016, Example 402::US10472354, Example 402 P2X purinoceptor 3 Homo sapiens 21.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320235 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320235&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397212 384223507 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 626092 C[C@@H](NC(=O)c1cc(OC[C@@H]2COCC(=O)N2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H22F3N5O4S/c1-12-6-27-21(36-12)15-3-14(4-18(5-15)35-10-17-9-34-11-19(32)31-17)20(33)30-13(2)16-7-28-22(29-8-16)23(24,25)26/h3-8,13,17H,9-11H2,1-2H3,(H,30,33)(H,31,32)/t13-,17+/m1/s1 QBCIMXIDQXCQLC-DYVFJYSZSA-N 320236 3-(5-methyl-1,3- thiazol-2-yl)-5- {[(3S)-5- oxomorpholin-3- yl]methoxy}-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 403::US10472354, Example 403 P2X purinoceptor 3 Homo sapiens 56.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320236 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320236&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397456 384223508 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 626094 C[C@@H](NC(=O)c1cc(OCC23CC(CO2)N(C3)C(=O)OC(C)(C)C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C29H32F3N5O5S/c1-16-10-33-24(43-16)19-6-18(23(38)36-17(2)20-11-34-25(35-12-20)29(30,31)32)7-22(8-19)40-15-28-9-21(13-41-28)37(14-28)26(39)42-27(3,4)5/h6-8,10-12,17,21H,9,13-15H2,1-5H3,(H,36,38)/t17-,21?,28?/m1/s1 FPSSQFUABOQNNZ-RWNQLPSJSA-N 320237 US10174016, Example 404::US10202369, Example 404::US10472354, Example 404::tert-butyl 1-{[3-(5- methyl-1,3-thiazol- 2-yl)-5-({(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}carbamoyl) phenoxy]methyl}-2- oxa-5- azabicyclo[2.2.1] heptane-5- carboxylate, as a mixture of 2 diastereoisomers P2X purinoceptor 3 Homo sapiens 44.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320237 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320237&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397508 384223509 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 626096 CC(C)N1CC2(COc3cc(cc(c3)-c3ncc(C)s3)C(=O)N[C@H](C)c3cnc(nc3)C(F)(F)F)CC1CO2 InChI=1S/C27H30F3N5O3S/c1-15(2)35-13-26(8-21(35)12-38-26)14-37-22-6-18(5-19(7-22)24-31-9-16(3)39-24)23(36)34-17(4)20-10-32-25(33-11-20)27(28,29)30/h5-7,9-11,15,17,21H,8,12-14H2,1-4H3,(H,34,36)/t17-,21?,26?/m1/s1 YPUYZHJKGABFEF-XJNIYMOYSA-N 320238 3-[(5-isopropyl-2- oxa-5-azabicyclo [2.2.1]hept-1-yl) methoxy]-5- (5-methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide, as a mixture of 2 diastereoisomers::US10174016, Example 405::US10202369, Example 405::US10472354, Example 405 P2X purinoceptor 3 Homo sapiens 17.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320238 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320238&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397496 384223510 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 626098 C[C@@H](NC(=O)c1cc(OCC23CC(CO2)N(C)C3)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C25H26F3N5O3S/c1-14-8-29-22(37-14)17-4-16(5-20(6-17)35-13-24-7-19(11-36-24)33(3)12-24)21(34)32-15(2)18-9-30-23(31-10-18)25(26,27)28/h4-6,8-10,15,19H,7,11-13H2,1-3H3,(H,32,34)/t15-,19?,24?/m1/s1 QZIIXNSQPLEQAW-QOFOLWBBSA-N 320239 3-[(5-methyl-2- oxa-5-azabicyclo [2.2.1]hept-1-yl) methoxy]-5- (5-methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide, as a mixture of 2 diastereoisomers::US10174016, Example 406::US10202369, Example 406::US10472354, Example 406 P2X purinoceptor 3 Homo sapiens 26.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320239 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320239&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397318 384223511 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 626100 C[C@@H](NC(=O)c1cc(OCC23CNC(CO2)C3)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H24F3N5O3S/c1-13-7-28-21(36-13)16-3-15(4-19(5-16)34-12-23-6-18(10-35-23)31-11-23)20(33)32-14(2)17-8-29-22(30-9-17)24(25,26)27/h3-5,7-9,14,18,31H,6,10-12H2,1-2H3,(H,32,33)/t14-,18?,23?/m1/s1 NAZJZFLNXXGFCR-IHDUPTFDSA-N 320240 3-(5-Methyl-1,3-thiazol-2-yl)-5-[2-oxa-5-azabicyclo[2.2.1]hept-1-ylmethoxy]-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide, as a Mixture of 2 Diastereoisomers::US10174016, Example 407::US10202369, Example 407::US10472354, Example 407 P2X purinoceptor 3 Homo sapiens 15.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320240 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320240&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397648 384223512 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 626102 CCCN1CC2(COc3cc(cc(c3)-c3ncc(C)s3)C(=O)N[C@H](C)c3cnc(nc3)C(F)(F)F)CC1CO2 InChI=1S/C27H30F3N5O3S/c1-4-5-35-14-26(9-21(35)13-38-26)15-37-22-7-18(6-19(8-22)24-31-10-16(2)39-24)23(36)34-17(3)20-11-32-25(33-12-20)27(28,29)30/h6-8,10-12,17,21H,4-5,9,13-15H2,1-3H3,(H,34,36)/t17-,21?,26?/m1/s1 AAPJJGZIWGLKBD-XJNIYMOYSA-N 320241 3-(5-methyl-1,3- thiazol-2-yl)-5-[(5- propyl-2- oxa-5-azabicyclo [2.2.1]hept-1-yl) methoxy]-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide, as a mixture of 2 diastereoisomers::US10174016, Example 408::US10202369, Example 408::US10472354, Example 408 P2X purinoceptor 3 Homo sapiens 32.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320241 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320241&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397789 384223513 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 626104 COC(=O)N1CC2(COc3cc(cc(c3)-c3ncc(C)s3)C(=O)N[C@H](C)c3cnc(nc3)C(F)(F)F)CC1CO2 InChI=1S/C26H26F3N5O5S/c1-14-8-30-22(40-14)17-4-16(21(35)33-15(2)18-9-31-23(32-10-18)26(27,28)29)5-20(6-17)38-13-25-7-19(11-39-25)34(12-25)24(36)37-3/h4-6,8-10,15,19H,7,11-13H2,1-3H3,(H,33,35)/t15-,19?,25?/m1/s1 ACUSXDHHFJWBEG-QYRGRQSGSA-N 320242 Methyl 1-{[3-(5-methyl-1,3-thiazol-2-yl)-5-({(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}carbamoyl)phenoxy]methyl}-2-oxa-5-azabicyclo[2.2.1]heptane-5-carboxylate, as a mixture of 2 diastereoisomers::US10174016, Example 409::US10202369, Example 409::US10472354, Example 409 P2X purinoceptor 3 Homo sapiens 22.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320242 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320242&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397200 384223514 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 626106 CCOC(=O)N1CC2(COc3cc(cc(c3)-c3ncc(C)s3)C(=O)N[C@H](C)c3cnc(nc3)C(F)(F)F)CC1CO2 InChI=1S/C27H28F3N5O5S/c1-4-38-25(37)35-13-26(8-20(35)12-40-26)14-39-21-6-17(5-18(7-21)23-31-9-15(2)41-23)22(36)34-16(3)19-10-32-24(33-11-19)27(28,29)30/h5-7,9-11,16,20H,4,8,12-14H2,1-3H3,(H,34,36)/t16-,20?,26?/m1/s1 MVNNYWBQRAUUBD-ORALUJHKSA-N 320243 Ethyl 1-{[3-(5-methyl-1,3-thiazol-2-yl)-5-({(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}carbamoyl)phenoxy]methyl}-2-oxa-5-azabicyclo[2.2.1]heptane-5-carboxylate, as a Mixture of 2 Diastereoisomers::US10174016, Example 410::US10202369, Example 410::US10472354, Example 410 P2X purinoceptor 3 Homo sapiens 22.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320243 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320243&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397180 384223515 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 626108 CCN1CCO[C@H](COc2cc(cc(c2)-c2ncc(C)s2)C(=O)N[C@H](C)c2cnc(nc2)C(F)(F)F)C1 InChI=1S/C25H28F3N5O3S/c1-4-33-5-6-35-21(13-33)14-36-20-8-17(7-18(9-20)23-29-10-15(2)37-23)22(34)32-16(3)19-11-30-24(31-12-19)25(26,27)28/h7-12,16,21H,4-6,13-14H2,1-3H3,(H,32,34)/t16-,21+/m1/s1 IJXNJADLTIUKEL-IERDGZPVSA-N 320244 3-{[(2S)-4-ethylmorpholin-2-yl]methoxy}-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 411::US10202369, Example 411::US10472354, Example 411 P2X purinoceptor 3 Homo sapiens 20.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320244 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320244&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397533 384223516 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 626110 C[C@H](NC(=O)c1cc(OC[C@H]2CN(CCO2)C(=O)OC(C)(C)C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C28H32F3N5O5S/c1-16-11-32-24(42-16)19-8-18(23(37)35-17(2)20-12-33-25(34-13-20)28(29,30)31)9-21(10-19)40-15-22-14-36(6-7-39-22)26(38)41-27(3,4)5/h8-13,17,22H,6-7,14-15H2,1-5H3,(H,35,37)/t17-,22+/m0/s1 OEKUZTDVCYAZBS-HTAPYJJXSA-N 320245 Tert-butyl (2R)-2- {[3-(5-methyl-1,3- thiazol-2-yl)-5- ({(1S)-1-[2- (trifluoromethyl) pyrimidin-5-yl] ethyl]carbamoyl) phenoxy]methyl} morpholine-4- carboxylate::US10174016, Example 412::US10202369, Example 412 P2X purinoceptor 3 Homo sapiens 687 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320245 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320245&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134338453 384223517 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 626112 C[C@H](NC(=O)c1cc(OC[C@H]2CNCCO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H24F3N5O3S/c1-13-8-28-21(35-13)16-5-15(6-18(7-16)34-12-19-11-27-3-4-33-19)20(32)31-14(2)17-9-29-22(30-10-17)23(24,25)26/h5-10,14,19,27H,3-4,11-12H2,1-2H3,(H,31,32)/t14-,19+/m0/s1 HRVUBTPQOQIHTK-IFXJQAMLSA-N 320246 3-(5-methyl- 1,3-thiazol-2- yl)-5-[(2R)- morpholin-2- ylmethoxy]-N- {(1S)-1-[2- (trifluoromethyl) pyrimidin-5-yl] ethyl}benzamide::US10174016, Example 413::US10202369, Example 413::US10472354, Example 413 P2X purinoceptor 3 Homo sapiens 597 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320246 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320246&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397518 384223518 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 626114 CCc1cnc(s1)-c1cc(OC[C@@H]2CNCCO2)cc(c1)C(=O)N[C@H](C)c1ccc(nn1)C(F)(F)F InChI=1S/C24H26F3N5O3S/c1-3-19-12-29-23(36-19)16-8-15(9-17(10-16)35-13-18-11-28-6-7-34-18)22(33)30-14(2)20-4-5-21(32-31-20)24(25,26)27/h4-5,8-10,12,14,18,28H,3,6-7,11,13H2,1-2H3,(H,30,33)/t14-,18+/m1/s1 PAVCMPZQEBSSQV-KDOFPFPSSA-N 320247 3-(5-ethyl-1,3- thiazol-2-yl)-5- [(2S)- morpholin-2- ylmethoxy]-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3-yl] ethyl}benzamide::US10174016, Example 414::US10202369, Example 414::US10472354, Example 414 P2X purinoceptor 3 Homo sapiens 29.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320247 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320247&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397150 384223519 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 626116 CCc1cnc(s1)-c1cc(OC[C@H]2CNCCO2)cc(c1)C(=O)N[C@H](C)c1ccc(nn1)C(F)(F)F InChI=1S/C24H26F3N5O3S/c1-3-19-12-29-23(36-19)16-8-15(9-17(10-16)35-13-18-11-28-6-7-34-18)22(33)30-14(2)20-4-5-21(32-31-20)24(25,26)27/h4-5,8-10,12,14,18,28H,3,6-7,11,13H2,1-2H3,(H,30,33)/t14-,18-/m1/s1 PAVCMPZQEBSSQV-RDTXWAMCSA-N 320248 3-(5-ethyl-1,3- thiazol-2-yl)-5- [(2R)- morpholin-2- ylmethoxy]-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3-yl] ethyl}benzamide::US10174016, Example 415::US10202369, Example 415::US10472354, Example 415 P2X purinoceptor 3 Homo sapiens 10.00 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320248 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320248&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397550 384223520 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 626118 C[C@H](NC(=O)c1cc(OC[C@H]2CN(C)CCO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H26F3N5O3S/c1-14-9-28-22(36-14)17-6-16(7-19(8-17)35-13-20-12-32(3)4-5-34-20)21(33)31-15(2)18-10-29-23(30-11-18)24(25,26)27/h6-11,15,20H,4-5,12-13H2,1-3H3,(H,31,33)/t15-,20+/m0/s1 MROBUJILSMBILX-MGPUTAFESA-N 320249 3-{[(2R)-4- methylmorpholin- 2-yl]methoxy}- 5-(5-methyl-1,3- thiazol-2-yl)- N-{(1S)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 416::US10202369, Example 416 P2X purinoceptor 3 Homo sapiens 227 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320249 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320249&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397764 384223521 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 626120 C[C@H](NC(=O)c1cc(OC[C@@H]2CN(C)CCO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H26F3N5O3S/c1-14-9-28-22(36-14)17-6-16(7-19(8-17)35-13-20-12-32(3)4-5-34-20)21(33)31-15(2)18-10-29-23(30-11-18)24(25,26)27/h6-11,15,20H,4-5,12-13H2,1-3H3,(H,31,33)/t15-,20-/m0/s1 MROBUJILSMBILX-YWZLYKJASA-N 320250 3-{[(2S)-4- methylmorpholin- 2-yl]methoxy}- 5-(5-methyl-1,3- thiazol-2-yl)- N-{(1S)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 417::US10202369, Example 417 P2X purinoceptor 3 Homo sapiens 434 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320250 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320250&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397582 384223522 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 626122 C[C@@H](NC(=O)c1cc(OC[C@@H]2CN(C)CCO2)cc(c1)-c1ncc(CO)s1)c1ccc(nn1)C(F)(F)F InChI=1S/C24H26F3N5O4S/c1-14(20-3-4-21(31-30-20)24(25,26)27)29-22(34)15-7-16(23-28-10-19(12-33)37-23)9-17(8-15)36-13-18-11-32(2)5-6-35-18/h3-4,7-10,14,18,33H,5-6,11-13H2,1-2H3,(H,29,34)/t14-,18+/m1/s1 LQESXXUCKRJIMX-KDOFPFPSSA-N 320251 3-(5-Ethyl-1,3- thiazol-2-yl)-5- {[(2S)-4- methylmorpholin- 2-yl]methoxy}- N-{(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl} benzamide::US10174016, Example 418 P2X purinoceptor 3 Homo sapiens 23.0 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320251 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320251&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134463464 384223523 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 626124 C[C@@H](NC(=O)c1cc(OC[C@H]2CN(C)CCO2)cc(c1)-c1ncc(CO)s1)c1ccc(nn1)C(F)(F)F InChI=1S/C24H26F3N5O4S/c1-14(20-3-4-21(31-30-20)24(25,26)27)29-22(34)15-7-16(23-28-10-19(12-33)37-23)9-17(8-15)36-13-18-11-32(2)5-6-35-18/h3-4,7-10,14,18,33H,5-6,11-13H2,1-2H3,(H,29,34)/t14-,18-/m1/s1 LQESXXUCKRJIMX-RDTXWAMCSA-N 320252 3-(5-ethyl-1,3- thiazol-2-yl)-5- {[(2R)-4- methylmorpholin- 2-yl]methoxy}- N-{(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl} benzamide::US10174016, Example 419 P2X purinoceptor 3 Homo sapiens 9.00 US Patent 10.7270/Q2GB264F aid1796643 US10174016 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J BEYER AKTIENGESELLSCHAFT http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320252 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320252&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134463465 384223524 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632320 CC(O)[C@@H](C)Oc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C22H23F3N4O3S/c1-11-8-26-20(33-11)16-5-15(6-18(7-16)32-14(4)13(3)30)19(31)29-12(2)17-9-27-21(28-10-17)22(23,24)25/h5-10,12-14,30H,1-4H3,(H,29,31)/t12-,13?,14-/m1/s1 FSGDRFBLPAILDE-WYAMFQBQSA-N 320173 US10174016, Example 340::US10472354, Example 340 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320173 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320173&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 138374916 384223446 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632322 C[C@@H](NC(=O)c1cc(OC2COC2)cc(c1)-c1ncc(C)s1)c1ccc(nc1)C(F)F InChI=1S/C22H21F2N3O3S/c1-12-8-26-22(31-12)16-5-15(6-17(7-16)30-18-10-29-11-18)21(28)27-13(2)14-3-4-19(20(23)24)25-9-14/h3-9,13,18,20H,10-11H2,1-2H3,(H,27,28)/t13-/m1/s1 VIFFUASYGYMCSF-CYBMUJFWSA-N 319997 N-{[(1R)-1-[6- (difluoromethyl) pyridin-3-yl]ethyl}-3- (5-methyl-1,3- thiazol-2-yl)-5- (oxetan-3- yloxy)benzamide::US10174016, Example 164::US10202369, Example 164::US10472354, Example 164 P2X purinoceptor 3 Homo sapiens 60.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319997 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319997&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397252 384223277 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632324 C[C@@H](NC(=O)c1cc(O[C@H]2C[C@@H](C2)N(C)C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H26F3N5O2S/c1-13-10-28-22(35-13)16-5-15(6-19(7-16)34-20-8-18(9-20)32(3)4)21(33)31-14(2)17-11-29-23(30-12-17)24(25,26)27/h5-7,10-12,14,18,20H,8-9H2,1-4H3,(H,31,33)/t14-,18-,20-/m1/s1 AGHYBRFMKRJHNY-LXGCGDOSSA-N 319998 3-{[trans-3- (dimethylamino) cyclobutyl]oxy}-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5-yl] ethyl}benzamide::US10174016, Example 165::US10202369, Example 165::US10472354, Example 165 P2X purinoceptor 3 Homo sapiens 81.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319998 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319998&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397549 384223278 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632326 Cc1cnc(s1)-c1cc(O[C@@H]2CCOC2)cc(c1)C(=O)NCc1cnc(nc1)C(F)(F)F InChI=1S/C21H19F3N4O3S/c1-12-7-26-19(32-12)15-4-14(5-17(6-15)31-16-2-3-30-11-16)18(29)25-8-13-9-27-20(28-10-13)21(22,23)24/h4-7,9-10,16H,2-3,8,11H2,1H3,(H,25,29)/t16-/m1/s1 MLKRPMMAEMGGNI-MRXNPFEDSA-N 319999 3-(5-methyl-1,3- thiazol-2-yl)-5- [(3R)- tetrahydrofuran-3- yloxy]-N-{[2- (trifluoromethyl) pyrimidin-5- yl]methyl}benzamide::US10174016, Example 166::US10202369, Example 166::US10472354, Example 166 P2X purinoceptor 3 Homo sapiens 40.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319999 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319999&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397360 384223279 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632328 Cc1cnc(s1)-c1cc(OC2COC2)cc(c1)C(=O)NCc1cnc(nc1)C(F)(F)F InChI=1S/C20H17F3N4O3S/c1-11-5-25-18(31-11)14-2-13(3-15(4-14)30-16-9-29-10-16)17(28)24-6-12-7-26-19(27-8-12)20(21,22)23/h2-5,7-8,16H,6,9-10H2,1H3,(H,24,28) AWMOXCQCRBHEDH-UHFFFAOYSA-N 320000 3-(5-methyl-1,3- thiazol-2-yl)-5- (oxetan-3-yloxy)- N-{[2- (trifluoromethyl) pyrimidin-5- yl]methyl}benzamide::US10174016, Example 167::US10202369, Example 167::US10472354, Example 167 P2X purinoceptor 3 Homo sapiens 72.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320000 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320000&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397228 384223280 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632330 C[C@@H](NC(=O)c1cc(O[C@H]2CN3CCC2CC3)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C25H26F3N5O2S/c1-14-10-29-23(36-14)18-7-17(8-20(9-18)35-21-13-33-5-3-16(21)4-6-33)22(34)32-15(2)19-11-30-24(31-12-19)25(26,27)28/h7-12,15-16,21H,3-6,13H2,1-2H3,(H,32,34)/t15-,21+/m1/s1 XGNFOBIXAZWFEF-VFNWGFHPSA-N 320001 3-[(3R)-1- azabicyclo[2.2.2] oct-3-yloxy]-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 168::US10202369, Example 168::US10472354, Example 168 P2X purinoceptor 3 Homo sapiens 19.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320001 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320001&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397190 384223281 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632332 CCc1cnc(s1)-c1cc(OC2COC2)cc(c1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C22H21F3N4O3S/c1-3-18-9-26-20(33-18)14-4-13(5-16(6-14)32-17-10-31-11-17)19(30)29-12(2)15-7-27-21(28-8-15)22(23,24)25/h4-9,12,17H,3,10-11H2,1-2H3,(H,29,30)/t12-/m1/s1 KJLXSAGNAKDMHX-GFCCVEGCSA-N 320002 3-(5-ethyl-1,3- thiazol-2-yl)-5- (oxetan-3-yloxy)- N-{(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 169::US10202369, Example 169::US10472354, Example 169 P2X purinoceptor 3 Homo sapiens 9.00 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320002 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320002&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397192 384223282 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632334 C[C@@H](NC(=O)c1cc(Oc2ccc(C)nn2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H19F3N6O2S/c1-12-4-5-19(32-31-12)34-18-7-15(6-16(8-18)21-27-9-13(2)35-21)20(33)30-14(3)17-10-28-22(29-11-17)23(24,25)26/h4-11,14H,1-3H3,(H,30,33)/t14-/m1/s1 YBWKZVABJNKBEG-CQSZACIVSA-N 320003 3-[(6- methylpyridazin-3- yl)oxy]-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 170::US10202369, Example 170::US10472354, Example 170 P2X purinoceptor 3 Homo sapiens 165 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320003 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320003&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397298 384223283 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632336 C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ccc(nc1)C(F)F InChI=1S/C23H23F2N3O3S/c1-13-10-27-23(32-13)17-7-16(8-19(9-17)31-18-5-6-30-12-18)22(29)28-14(2)15-3-4-20(21(24)25)26-11-15/h3-4,7-11,14,18,21H,5-6,12H2,1-2H3,(H,28,29)/t14-,18-/m1/s1 UIFKRKFOSZCXTP-RDTXWAMCSA-N 320004 N-{(1R)-1-[6- (difluoromethyl) pyridin-3-yl]ethyl}-3- (5-methyl-1,3- thiazol-2-yl)-5- [(3R)- tetrahydrofuran-3- yloxy]benzamide::US10174016, Example 171::US10202369, Example 171::US10472354, Example 171 P2X purinoceptor 3 Homo sapiens 26.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320004 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320004&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397544 384223284 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632338 C[C@@H](NC(=O)c1cc(O[C@H]2CN3CCC2CC3)cc(c1)-c1ncc(C)s1)c1ccc(nc1)C(F)(F)F InChI=1S/C26H27F3N4O2S/c1-15-12-31-25(36-15)20-9-19(10-21(11-20)35-22-14-33-7-5-17(22)6-8-33)24(34)32-16(2)18-3-4-23(30-13-18)26(27,28)29/h3-4,9-13,16-17,22H,5-8,14H2,1-2H3,(H,32,34)/t16-,22+/m1/s1 BTZKHRISYBAOIH-ZHRRBRCNSA-N 320005 3-[(3R)-1- azabicyclo[2.2.2] oct-3-yloxy]-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[6- (trifluoromethyl) pyridin-3- yl]ethyl}benzamide::US10174016, Example 172::US10202369, Example 172::US10472354, Example 172 P2X purinoceptor 3 Homo sapiens 31.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320005 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320005&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397643 384223285 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632340 CCc1cnc(s1)-c1cc(O[C@@H]2CN3CCC2CC3)cc(c1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C26H28F3N5O2S/c1-3-21-13-30-24(37-21)18-8-17(9-20(10-18)36-22-14-34-6-4-16(22)5-7-34)23(35)33-15(2)19-11-31-25(32-12-19)26(27,28)29/h8-13,15-16,22H,3-7,14H2,1-2H3,(H,33,35)/t15-,22-/m1/s1 SVMXJSAEFPTNIN-IVZQSRNASA-N 320006 3-[(3S)-1- azabicyclo[2.2.2] oct-3-yloxy]-5-(5- ethyl-1,3-thiazol- 2-yl)-N-{(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 173::US10202369, Example 173::US10472354, Example 173 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320006 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320006&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397592 384223286 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632342 CCc1cnc(s1)-c1cc(O[C@H]2CN3CCC2CC3)cc(c1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C26H28F3N5O2S/c1-3-21-13-30-24(37-21)18-8-17(9-20(10-18)36-22-14-34-6-4-16(22)5-7-34)23(35)33-15(2)19-11-31-25(32-12-19)26(27,28)29/h8-13,15-16,22H,3-7,14H2,1-2H3,(H,33,35)/t15-,22+/m1/s1 SVMXJSAEFPTNIN-QRQCRPRQSA-N 320007 3-[(3R)-1- azabicyclo[2.2.2] oct-3-yloxy]-5-(5- ethyl-1,3-thiazol- 2-yl)-N-{(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 174::US10202369, Example 174::US10472354, Example 174 P2X purinoceptor 3 Homo sapiens 11.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320007 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320007&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397479 384223287 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632344 C[C@@H](NC(=O)c1cc(O[C@@H]2CN3CCC2CC3)cc(c1)-c1ncc(C)s1)c1ccc(nc1)C(F)(F)F InChI=1S/C26H27F3N4O2S/c1-15-12-31-25(36-15)20-9-19(10-21(11-20)35-22-14-33-7-5-17(22)6-8-33)24(34)32-16(2)18-3-4-23(30-13-18)26(27,28)29/h3-4,9-13,16-17,22H,5-8,14H2,1-2H3,(H,32,34)/t16-,22-/m1/s1 BTZKHRISYBAOIH-OPAMFIHVSA-N 320008 3-[(3S)-1- azabicyclo[2.2.2] oct-3-yloxy]-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[6- (trifluoromethyl) pyridin-3- yl]ethyl}benzamide::US10174016, Example 175::US10202369, Example 175::US10472354, Example 175 P2X purinoceptor 3 Homo sapiens 23.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320008 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320008&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397558 384223288 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632346 C[C@@H](NC(=O)c1cc(Oc2nnc(C)s2)cc(c1)-c1ncc(C)s1)c1ccc(nc1)C(F)(F)F InChI=1S/C22H18F3N5O2S2/c1-11-9-27-20(33-11)16-6-15(7-17(8-16)32-21-30-29-13(3)34-21)19(31)28-12(2)14-4-5-18(26-10-14)22(23,24)25/h4-10,12H,1-3H3,(H,28,31)/t12-/m1/s1 IWXLKQRNUPTLAV-GFCCVEGCSA-N 320009 3-[(5-methyl- 1,3,4-thiadiazol-2- yl)oxy]-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[6- (trifluoromethyl) pyridin-3- yl]ethyl}benzamide::US10174016, Example 176::US10202369, Example 176::US10472354, Example 176 P2X purinoceptor 3 Homo sapiens 29.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320009 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320009&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397692 384223289 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632348 C[C@@H](NC(=O)c1cc(OC[C@H]2COCCO2)cc(c1)-c1ncc(C)s1)c1ccc(nc1)C(F)(F)F InChI=1S/C24H24F3N3O4S/c1-14-10-29-23(35-14)18-7-17(8-19(9-18)34-13-20-12-32-5-6-33-20)22(31)30-15(2)16-3-4-21(28-11-16)24(25,26)27/h3-4,7-11,15,20H,5-6,12-13H2,1-2H3,(H,30,31)/t15-,20-/m1/s1 LZEBVIBIWJOALL-FOIQADDNSA-N 320010 3-[(2R)-1,4-dioxan-2- ylmethoxy]-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[6- (trifluoromethyl) pyridin-3- yl]ethyl}benzamide::US10174016, Example 177::US10202369, Example 177::US10472354, Example 177 P2X purinoceptor 3 Homo sapiens 14.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320010 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320010&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397515 384223290 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632350 C[C@@H](NC(=O)c1cc(OC[C@H]2COCCO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H23F3N4O4S/c1-13-8-27-21(35-13)16-5-15(6-18(7-16)34-12-19-11-32-3-4-33-19)20(31)30-14(2)17-9-28-22(29-10-17)23(24,25)26/h5-10,14,19H,3-4,11-12H2,1-2H3,(H,30,31)/t14-,19-/m1/s1 NQEFGEXCJWOEFF-AUUYWEPGSA-N 320011 3-[(2R)-1,4-dioxan-2- ylmethoxy]-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 178::US10202369, Example 178::US10472354, Example 178 P2X purinoceptor 3 Homo sapiens 39.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320011 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320011&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397229 384223291 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632352 C[C@@H](NC(=O)c1cc(OC[C@H]2COCCO2)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F InChI=1S/C23H23F3N4O4S/c1-13-10-27-22(35-13)16-7-15(8-17(9-16)34-12-18-11-32-5-6-33-18)21(31)28-14(2)19-3-4-20(30-29-19)23(24,25)26/h3-4,7-10,14,18H,5-6,11-12H2,1-2H3,(H,28,31)/t14-,18-/m1/s1 PZDPWIRLHUGUOG-RDTXWAMCSA-N 320012 3-[(2R)-1,4-dioxan-2- ylmethoxy]-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3-yl]ethyl} benzamide::US10174016, Example 179::US10202369, Example 179::US10472354, Example 179 P2X purinoceptor 3 Homo sapiens 13.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320012 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320012&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397371 384223292 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632354 C[C@@H](NC(=O)c1cc(OC[C@@H]2COCCO2)cc(c1)-c1ncc(C)s1)c1ccc(nc1)C(F)(F)F InChI=1S/C24H24F3N3O4S/c1-14-10-29-23(35-14)18-7-17(8-19(9-18)34-13-20-12-32-5-6-33-20)22(31)30-15(2)16-3-4-21(28-11-16)24(25,26)27/h3-4,7-11,15,20H,5-6,12-13H2,1-2H3,(H,30,31)/t15-,20+/m1/s1 LZEBVIBIWJOALL-QRWLVFNGSA-N 320013 3-[(2S)-1,4-dioxan- 2-ylmethoxy]-5-(5- methyl-1,3-thiazol-2-yl)- N-{(1R)-1-[6- (trifluoromethyl)pyridin- 3-yl]ethyl}benzamide::US10174016, Example 180::US10202369, Example 180::US10472354, Example 180 P2X purinoceptor 3 Homo sapiens 31.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320013 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320013&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397137 384223293 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632356 C[C@@H](NC(=O)c1cc(OC[C@@H]2COCCO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H23F3N4O4S/c1-13-8-27-21(35-13)16-5-15(6-18(7-16)34-12-19-11-32-3-4-33-19)20(31)30-14(2)17-9-28-22(29-10-17)23(24,25)26/h5-10,14,19H,3-4,11-12H2,1-2H3,(H,30,31)/t14-,19+/m1/s1 NQEFGEXCJWOEFF-KUHUBIRLSA-N 320014 3-[(2S)-1,4-dioxan- 2-ylmethoxy]-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 181::US10202369, Example 181::US10472354, Example 181 P2X purinoceptor 3 Homo sapiens 19.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320014 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320014&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397128 384223294 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632358 C[C@@H](NC(=O)c1cc(OC[C@@H]2COCCO2)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F InChI=1S/C23H23F3N4O4S/c1-13-10-27-22(35-13)16-7-15(8-17(9-16)34-12-18-11-32-5-6-33-18)21(31)28-14(2)19-3-4-20(30-29-19)23(24,25)26/h3-4,7-10,14,18H,5-6,11-12H2,1-2H3,(H,28,31)/t14-,18+/m1/s1 PZDPWIRLHUGUOG-KDOFPFPSSA-N 320015 3-[(2S)-1,4-dioxan- 2-ylmethoxy]-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl}benzamide::US10174016, Example 182::US10202369, Example 182::US10472354, Example 182 P2X purinoceptor 3 Homo sapiens 63.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320015 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320015&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397642 384223295 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632360 CC(O)C(C)Oc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1ccc(nn1)C(F)(F)F InChI=1S/C22H23F3N4O3S/c1-11-10-26-21(33-11)16-7-15(8-17(9-16)32-14(4)13(3)30)20(31)27-12(2)18-5-6-19(29-28-18)22(23,24)25/h5-10,12-14,30H,1-4H3,(H,27,31)/t12-,13?,14?/m1/s1 LMHZXBDHIYABCN-IYXRBSQSSA-N 320016 Trans Isomer 1; 3- {[3-hydroxybutan- 2-yl]oxy}-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl}benzamide::US10174016, Example 183::US10202369, Example 230::US10472354, Example 231 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320016 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320016&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397175 384223296 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632362 CC(O)C(C)Oc1cc(cc(c1)-c1ncc(Cl)s1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C21H20ClF3N4O3S/c1-10(15-7-27-20(28-8-15)21(23,24)25)29-18(31)13-4-14(19-26-9-17(22)33-19)6-16(5-13)32-12(3)11(2)30/h4-12,30H,1-3H3,(H,29,31)/t10-,11?,12?/m1/s1 QTLJKKFADUZLKR-VOMCLLRMSA-N 320017 Trans Isomer 1; 3- (5-chloro-1,3- thiazol-2-yl)-5-{[3- hydroxybutan-2- yl]oxy}-N-{(1R)-1- [2-(trifluoromethyl) pyrimidin-5-yl]ethyl} benzamide::US10174016, Example 184::US10174016, Example 185::US10174016, Example 187::US10174016, Example 188::US10202369, Example 188::US10472354, Example 188 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320017 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320017&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397494 384223297 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632364 CC(O)C(C)Oc1cc(cc(c1)-c1ncc(Cl)s1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C21H20ClF3N4O3S/c1-10(15-7-27-20(28-8-15)21(23,24)25)29-18(31)13-4-14(19-26-9-17(22)33-19)6-16(5-13)32-12(3)11(2)30/h4-12,30H,1-3H3,(H,29,31)/t10-,11?,12?/m1/s1 QTLJKKFADUZLKR-VOMCLLRMSA-N 320017 Trans Isomer 1; 3- (5-chloro-1,3- thiazol-2-yl)-5-{[3- hydroxybutan-2- yl]oxy}-N-{(1R)-1- [2-(trifluoromethyl) pyrimidin-5-yl]ethyl} benzamide::US10174016, Example 184::US10174016, Example 185::US10174016, Example 187::US10174016, Example 188::US10202369, Example 188::US10472354, Example 188 P2X purinoceptor 3 Homo sapiens 4.00 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320017 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320017&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397494 384223297 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632366 CC(O)C(C)Oc1cc(cc(c1)-c1ncc(Cl)s1)C(=O)N[C@H](C)c1ccc(nc1)C(F)(F)F InChI=1S/C22H21ClF3N3O3S/c1-11(14-4-5-18(27-9-14)22(24,25)26)29-20(31)15-6-16(21-28-10-19(23)33-21)8-17(7-15)32-13(3)12(2)30/h4-13,30H,1-3H3,(H,29,31)/t11-,12?,13?/m1/s1 HTVWJAQZHONFAU-PNESKVBLSA-N 320019 Trans Isomer 1; 3- (5-chloro-1,3- thiazol-2-yl)-5-{[3- hydroxybutan-2- yl]oxy}-N-{(1R)-1- [6-(trifluoromethyl) pyridin-3-yl]ethyl} benzamide::US10174016, Example 186::US10174016, Example 189::US10202369, Example 189::US10472354, Example 189 P2X purinoceptor 3 Homo sapiens 10.00 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320019 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320019&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397322 384223298 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632368 CC(O)C(C)Oc1cc(cc(c1)-c1ncc(Cl)s1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C21H20ClF3N4O3S/c1-10(15-7-27-20(28-8-15)21(23,24)25)29-18(31)13-4-14(19-26-9-17(22)33-19)6-16(5-13)32-12(3)11(2)30/h4-12,30H,1-3H3,(H,29,31)/t10-,11?,12?/m1/s1 QTLJKKFADUZLKR-VOMCLLRMSA-N 320017 Trans Isomer 1; 3- (5-chloro-1,3- thiazol-2-yl)-5-{[3- hydroxybutan-2- yl]oxy}-N-{(1R)-1- [2-(trifluoromethyl) pyrimidin-5-yl]ethyl} benzamide::US10174016, Example 184::US10174016, Example 185::US10174016, Example 187::US10174016, Example 188::US10202369, Example 188::US10472354, Example 188 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320017 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320017&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397494 384223297 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632370 CC(O)C(C)Oc1cc(cc(c1)-c1ncc(Cl)s1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C21H20ClF3N4O3S/c1-10(15-7-27-20(28-8-15)21(23,24)25)29-18(31)13-4-14(19-26-9-17(22)33-19)6-16(5-13)32-12(3)11(2)30/h4-12,30H,1-3H3,(H,29,31)/t10-,11?,12?/m1/s1 QTLJKKFADUZLKR-VOMCLLRMSA-N 320017 Trans Isomer 1; 3- (5-chloro-1,3- thiazol-2-yl)-5-{[3- hydroxybutan-2- yl]oxy}-N-{(1R)-1- [2-(trifluoromethyl) pyrimidin-5-yl]ethyl} benzamide::US10174016, Example 184::US10174016, Example 185::US10174016, Example 187::US10174016, Example 188::US10202369, Example 188::US10472354, Example 188 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320017 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320017&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397494 384223297 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632372 CC(O)C(C)Oc1cc(cc(c1)-c1ncc(Cl)s1)C(=O)N[C@H](C)c1ccc(nc1)C(F)(F)F InChI=1S/C22H21ClF3N3O3S/c1-11(14-4-5-18(27-9-14)22(24,25)26)29-20(31)15-6-16(21-28-10-19(23)33-21)8-17(7-15)32-13(3)12(2)30/h4-13,30H,1-3H3,(H,29,31)/t11-,12?,13?/m1/s1 HTVWJAQZHONFAU-PNESKVBLSA-N 320019 Trans Isomer 1; 3- (5-chloro-1,3- thiazol-2-yl)-5-{[3- hydroxybutan-2- yl]oxy}-N-{(1R)-1- [6-(trifluoromethyl) pyridin-3-yl]ethyl} benzamide::US10174016, Example 186::US10174016, Example 189::US10202369, Example 189::US10472354, Example 189 P2X purinoceptor 3 Homo sapiens 8.00 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320019 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320019&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397322 384223298 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632374 C[C@@H](NC(=O)c1cc(OC2CCCN(C2)C(=O)OC(C)(C)C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C28H32F3N5O4S/c1-16-12-32-24(41-16)19-9-18(23(37)35-17(2)20-13-33-25(34-14-20)28(29,30)31)10-22(11-19)39-21-7-6-8-36(15-21)26(38)40-27(3,4)5/h9-14,17,21H,6-8,15H2,1-5H3,(H,35,37)/t17-,21?/m1/s1 GMVSECYUKAWWNE-OQHSHRKDSA-N 320023 US10174016, Example 190::US10202369, Example 190::US10472354, Example 190::tert-Butyl (3R)-3-[3-(5-methyl-1,3-thiazol-2-yl)-5-({(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}carbamoyl)phenoxy]piperidine-1-carboxylate, as a mixture of diastereoisomers P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320023 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320023&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134338447 384223299 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632376 CC#CCOc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1ccc(C)nn1 InChI=1S/C22H22N4O2S/c1-5-6-9-28-19-11-17(10-18(12-19)22-23-13-15(3)29-22)21(27)24-16(4)20-8-7-14(2)25-26-20/h7-8,10-13,16H,9H2,1-4H3,(H,24,27)/t16-/m1/s1 WEKOJPFCJMIPGB-MRXNPFEDSA-N 320024 3-(but-2-yn-1- yloxy)-N-[(1R)- 1-(6- methylpyridazin- 3- yl)ethyl]-5- (5-methyl- 1,3-thiazol-2-yl) benzamide::US10174016, Example 191::US10202369, Example 191::US10472354, Example 191 P2X purinoceptor 3 Homo sapiens 61.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320024 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320024&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397657 384223300 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632378 C[C@@H](NC(=O)c1cc(O[C@@H]2CN3CCC2CC3)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C25H26F3N5O2S/c1-14-10-29-23(36-14)18-7-17(8-20(9-18)35-21-13-33-5-3-16(21)4-6-33)22(34)32-15(2)19-11-30-24(31-12-19)25(26,27)28/h7-12,15-16,21H,3-6,13H2,1-2H3,(H,32,34)/t15-,21-/m1/s1 XGNFOBIXAZWFEF-QVKFZJNVSA-N 320025 3-[(3S)-1- azabicyclo[2.2.2] oct-3-yloxy]-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5-yl] ethyl} benzamide::US10174016, Example 192::US10202369, Example 192::US10472354, Example 192 P2X purinoceptor 3 Homo sapiens 12.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320025 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320025&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397263 384223301 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632380 C[C@@H](NC(=O)c1cc(OC2COC2)cc(c1)-c1ncc(C)s1)c1nnc(s1)C(F)(F)F InChI=1S/C19H17F3N4O3S2/c1-9-6-23-17(30-9)12-3-11(4-13(5-12)29-14-7-28-8-14)15(27)24-10(2)16-25-26-18(31-16)19(20,21)22/h3-6,10,14H,7-8H2,1-2H3,(H,24,27)/t10-/m1/s1 CAKLWYTTWVXMCY-SNVBAGLBSA-N 320026 3-(5-Methyl-1,3-thiazol-2-yl)-5-(oxetan-3-yloxy)-N-{1-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]ethyl}benzamide::US10174016, Example 193::US10202369, Example 194::US10472354, Example 194 P2X purinoceptor 3 Homo sapiens 2705 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320026 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320026&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 138374896 384223302 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632382 C[C@H](NC(=O)c1cc(OC2COC2)cc(c1)-c1ncc(C)s1)c1nnc(s1)C(F)(F)F InChI=1S/C19H17F3N4O3S2/c1-9-6-23-17(30-9)12-3-11(4-13(5-12)29-14-7-28-8-14)15(27)24-10(2)16-25-26-18(31-16)19(20,21)22/h3-6,10,14H,7-8H2,1-2H3,(H,24,27)/t10-/m0/s1 CAKLWYTTWVXMCY-JTQLQIEISA-N 320027 US10174016, Example 194::US10202369, Example 193::US10472354, Example 193 P2X purinoceptor 3 Homo sapiens 46.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320027 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320027&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 138374897 384223303 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632384 C[C@@H](NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(C)s1)c1nnc(s1)C(F)(F)F InChI=1S/C21H21F3N4O3S2/c1-11-10-25-19(32-11)14-7-13(8-16(9-14)31-15-3-5-30-6-4-15)17(29)26-12(2)18-27-28-20(33-18)21(22,23)24/h7-10,12,15H,3-6H2,1-2H3,(H,26,29)/t12-/m1/s1 NWTVSPCFEGLAFO-GFCCVEGCSA-N 320028 3-(5-methyl-1,3-thiazol-2-yl)-5-(tetrahydro-2H-pyran-4-yloxy)-N-{1-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]ethyl}benzamide::US10174016, Example 195::US10202369, Example 196::US10472354, Example 196 P2X purinoceptor 3 Homo sapiens 380 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320028 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320028&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 138374898 384223304 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632386 C[C@H](NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(C)s1)c1nnc(s1)C(F)(F)F InChI=1S/C21H21F3N4O3S2/c1-11-10-25-19(32-11)14-7-13(8-16(9-14)31-15-3-5-30-6-4-15)17(29)26-12(2)18-27-28-20(33-18)21(22,23)24/h7-10,12,15H,3-6H2,1-2H3,(H,26,29)/t12-/m0/s1 NWTVSPCFEGLAFO-LBPRGKRZSA-N 320029 US10174016, Example 196::US10202369, Example 195::US10472354, Example 195 P2X purinoceptor 3 Homo sapiens 19.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320029 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320029&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 138374899 384223305 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632388 C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1nnc(s1)C(F)(F)F InChI=1S/C20H19F3N4O3S2/c1-10-8-24-18(31-10)13-5-12(6-15(7-13)30-14-3-4-29-9-14)16(28)25-11(2)17-26-27-19(32-17)20(21,22)23/h5-8,11,14H,3-4,9H2,1-2H3,(H,25,28)/t11-,14-/m1/s1 SHLRNWXFYHGFLL-BXUZGUMPSA-N 320030 3-(5-methyl-1,3-thiazol-2-yl)-5-[(3R)-tetrahydrofuran-3-yloxy]-N-{1-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]ethyl}benzamide::US10174016, Example 197::US10202369, Example 198::US10472354, Example 198 P2X purinoceptor 3 Homo sapiens 1152 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320030 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320030&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397585 384223306 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632390 C[C@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1nnc(s1)C(F)(F)F InChI=1S/C20H19F3N4O3S2/c1-10-8-24-18(31-10)13-5-12(6-15(7-13)30-14-3-4-29-9-14)16(28)25-11(2)17-26-27-19(32-17)20(21,22)23/h5-8,11,14H,3-4,9H2,1-2H3,(H,25,28)/t11-,14+/m0/s1 SHLRNWXFYHGFLL-SMDDNHRTSA-N 320031 US10174016, Example 198::US10202369, Example 197::US10472354, Example 197 P2X purinoceptor 3 Homo sapiens 30.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320031 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320031&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 138374900 384223307 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632392 C[C@@H](NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1nnc(s1)C(F)(F)F InChI=1S/C20H19F3N4O3S2/c1-10-8-24-18(31-10)13-5-12(6-15(7-13)30-14-3-4-29-9-14)16(28)25-11(2)17-26-27-19(32-17)20(21,22)23/h5-8,11,14H,3-4,9H2,1-2H3,(H,25,28)/t11-,14+/m1/s1 SHLRNWXFYHGFLL-RISCZKNCSA-N 320032 3-(5-methyl-1,3-thiazol-2-yl)-5-[(3S)-tetrahydrofuran-3-yloxy]-N-{1-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]ethyl}benzamide::US10174016, Example 199::US10202369, Example 200::US10472354, Example 200 P2X purinoceptor 3 Homo sapiens 1544 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320032 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320032&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397243 384223308 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632394 C[C@H](NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1nnc(s1)C(F)(F)F InChI=1S/C20H19F3N4O3S2/c1-10-8-24-18(31-10)13-5-12(6-15(7-13)30-14-3-4-29-9-14)16(28)25-11(2)17-26-27-19(32-17)20(21,22)23/h5-8,11,14H,3-4,9H2,1-2H3,(H,25,28)/t11-,14-/m0/s1 SHLRNWXFYHGFLL-FZMZJTMJSA-N 320033 US10174016, Example 200::US10202369, Example 199::US10472354, Example 199 P2X purinoceptor 3 Homo sapiens 30.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320033 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320033&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 138374901 384223309 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632396 C[C@@H](NC(=O)c1cc(OC2CCNCC2)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F InChI=1S/C23H24F3N5O2S/c1-13-12-28-22(34-13)16-9-15(10-18(11-16)33-17-5-7-27-8-6-17)21(32)29-14(2)19-3-4-20(31-30-19)23(24,25)26/h3-4,9-12,14,17,27H,5-8H2,1-2H3,(H,29,32)/t14-/m1/s1 JTGZQMREWDOCMX-CQSZACIVSA-N 320034 3-(5-methyl-1,3-thiazol-2-yl)-5-(piperidin-4-yloxy)-N-{(1R)-1-[6-(trifluoromethyl)pyridazin-3-yl]ethyl}benzamide::US10174016, Example 201::US10202369, Example 201::US10472354, Example 201 P2X purinoceptor 3 Homo sapiens 16.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320034 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320034&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397404 384223310 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632398 C[C@@H](NC(=O)c1cc(OC2CC3(CNC3)C2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H24F3N5O2S/c1-13-8-29-21(35-13)16-3-15(4-18(5-16)34-19-6-23(7-19)11-28-12-23)20(33)32-14(2)17-9-30-22(31-10-17)24(25,26)27/h3-5,8-10,14,19,28H,6-7,11-12H2,1-2H3,(H,32,33)/t14-/m1/s1 KMHSWHWDZALJOK-CQSZACIVSA-N 320035 3-(2- azaspiro[3.3] hept- 6-yloxy)-5-(5- methyl-1,3- thiazol-2- yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 202::US10202369, Example 202::US10472354, Example 202 P2X purinoceptor 3 Homo sapiens 42.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320035 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320035&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397731 384223311 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632400 C[C@@H](NC(=O)c1cc(O[C@H]2CCNC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C22H22F3N5O2S/c1-12-8-27-20(33-12)15-5-14(6-18(7-15)32-17-3-4-26-11-17)19(31)30-13(2)16-9-28-21(29-10-16)22(23,24)25/h5-10,13,17,26H,3-4,11H2,1-2H3,(H,30,31)/t13-,17+/m1/s1 IUOVXWVSORDTAX-DYVFJYSZSA-N 320036 3-(5-methyl- 1,3-thiazol-2- yl)-5-[(3S)- pyrrolidin-3- yloxy]-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 203::US10202369, Example 203::US10472354, Example 203 P2X purinoceptor 3 Homo sapiens 36.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320036 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320036&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397829 384223312 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632402 C[C@@H](NC(=O)c1cc(OC2CCNCC2F)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H23F4N5O2S/c1-12-8-29-21(35-12)15-5-14(6-17(7-15)34-19-3-4-28-11-18(19)24)20(33)32-13(2)16-9-30-22(31-10-16)23(25,26)27/h5-10,13,18-19,28H,3-4,11H2,1-2H3,(H,32,33)/t13-,18?,19?/m1/s1 IVYMHMMQRKFONZ-XYJCDUHRSA-N 320037 3-{[3- fluoropiperidin- 4-yl]oxy}-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide, as a mixture of cis isomers::US10174016, Example 204::US10202369, Example 204::US10472354, Example 204 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320037 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320037&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397537 384223313 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632404 C[C@@H](NC(=O)c1cc(OC2CCCNC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H24F3N5O2S/c1-13-9-28-21(34-13)16-6-15(7-19(8-16)33-18-4-3-5-27-12-18)20(32)31-14(2)17-10-29-22(30-11-17)23(24,25)26/h6-11,14,18,27H,3-5,12H2,1-2H3,(H,31,32)/t14-,18?/m1/s1 YIMSHVDFMHXVTO-IKJXHCRLSA-N 322394 3-(5-methyl-1,3-thiazol-2-yl)-5-(piperidin-3-yloxy)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10183937, Example 205::US10202369, Example 205::US10472354, Example 206 P2X purinoceptor 3 Homo sapiens 4.00 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322394 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322394&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397478 384225457 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632406 C[C@H](NC(=O)c1cc(OC2CCCNC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H24F3N5O2S/c1-13-9-28-21(34-13)16-6-15(7-19(8-16)33-18-4-3-5-27-12-18)20(32)31-14(2)17-10-29-22(30-11-17)23(24,25)26/h6-11,14,18,27H,3-5,12H2,1-2H3,(H,31,32)/t14-,18?/m0/s1 YIMSHVDFMHXVTO-PIVQAISJSA-N 322395 US10183937, Example 206::US10202369, Example 206::US10472354, Example 205 P2X purinoceptor 3 Homo sapiens 31.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322395 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322395&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 138375407 384225458 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632408 C[C@@H](NC(=O)c1cc(OC2CCNC(C2)C(F)(F)F)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H23F6N5O2S/c1-12-9-32-21(38-12)15-5-14(6-18(7-15)37-17-3-4-31-19(8-17)23(25,26)27)20(36)35-13(2)16-10-33-22(34-11-16)24(28,29)30/h5-7,9-11,13,17,19,31H,3-4,8H2,1-2H3,(H,35,36)/t13-,17?,19?/m1/s1 RLIMWYRKEDYMPQ-UYCDIGJJSA-N 322396 3-(5-methyl-1,3-thiazol-2-yl)-5-{[2-(trifluoromethyl)piperidin-4-yl]oxy}-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10183937, Example 207::US10202369, Example 207::US10472354, Example 208 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322396 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322396&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397615 384225459 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632410 C[C@H](NC(=O)c1cc(OC2CCNC(C2)C(F)(F)F)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H23F6N5O2S/c1-12-9-32-21(38-12)15-5-14(6-18(7-15)37-17-3-4-31-19(8-17)23(25,26)27)20(36)35-13(2)16-10-33-22(34-11-16)24(28,29)30/h5-7,9-11,13,17,19,31H,3-4,8H2,1-2H3,(H,35,36)/t13-,17?,19?/m0/s1 RLIMWYRKEDYMPQ-LJSZUPLFSA-N 322397 US10183937, Example 208::US10202369, Example 208::US10472354, Example 207 P2X purinoceptor 3 Homo sapiens 2.00 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322397 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322397&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 138375408 384225460 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632412 C[C@@H](NC(=O)c1cc(OC2CC3CC2CN3C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C25H26F3N5O2S/c1-13-9-29-23(36-13)16-4-15(6-20(7-16)35-21-8-19-5-17(21)12-33(19)3)22(34)32-14(2)18-10-30-24(31-11-18)25(26,27)28/h4,6-7,9-11,14,17,19,21H,5,8,12H2,1-3H3,(H,32,34)/t14-,17?,19?,21?/m1/s1 BQHHMEMNTIGDMM-LXOQGKBISA-N 320042 3-{[2-methyl-2-azabicyclo[2.2.1]hept-5-yl]oxy}-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 209::US10202369, Example 209::US10472354, Example 209 P2X purinoceptor 3 Homo sapiens 30.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320042 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320042&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397807 384223318 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632414 C[C@@H](NC(=O)c1cc(OC2CCN(C)CC2)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F InChI=1S/C24H26F3N5O2S/c1-14-13-28-23(35-14)17-10-16(11-19(12-17)34-18-6-8-32(3)9-7-18)22(33)29-15(2)20-4-5-21(31-30-20)24(25,26)27/h4-5,10-13,15,18H,6-9H2,1-3H3,(H,29,33)/t15-/m1/s1 HKVPHDDZBSOGJS-OAHLLOKOSA-N 320043 3-[(1- methylpiperidin- 4-yl)oxy]-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl} benzamide::US10174016, Example 210::US10202369, Example 210::US10472354, Example 210 P2X purinoceptor 3 Homo sapiens 12.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320043 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320043&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397346 384223319 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632416 C[C@@H](NC(=O)c1cc(OC2CN(C)C2)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F InChI=1S/C22H22F3N5O2S/c1-12-9-26-21(33-12)15-6-14(7-16(8-15)32-17-10-30(3)11-17)20(31)27-13(2)18-4-5-19(29-28-18)22(23,24)25/h4-9,13,17H,10-11H2,1-3H3,(H,27,31)/t13-/m1/s1 IRYKBWGBPIOTOU-CYBMUJFWSA-N 320044 3-[(1- methylazetidin- 3-yl)oxy]-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl} benzamide::US10174016, Example 211::US10202369, Example 211::US10472354, Example 211 P2X purinoceptor 3 Homo sapiens 395 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320044 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320044&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397301 384223320 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632418 C[C@@H](NC(=O)c1cc(OC2CCN(C)CC2F)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H25F4N5O2S/c1-13-9-29-22(36-13)16-6-15(7-18(8-16)35-20-4-5-33(3)12-19(20)25)21(34)32-14(2)17-10-30-23(31-11-17)24(26,27)28/h6-11,14,19-20H,4-5,12H2,1-3H3,(H,32,34)/t14-,19?,20?/m1/s1 XFFHESNTQMKRAI-WPUWVODUSA-N 320045 3-[(3-fluoro-1- methylpiperidin-4- yl)oxy]-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide, as a single unknown isomer::US10174016, Example 212::US10202369, Example 212::US10472354, Example 212 P2X purinoceptor 3 Homo sapiens 4.00 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320045 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320045&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397317 384223321 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632420 C[C@@H](NC(=O)c1cc(OCC2(CC2)N(C)C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H26F3N5O2S/c1-14-10-28-21(35-14)17-7-16(8-19(9-17)34-13-23(5-6-23)32(3)4)20(33)31-15(2)18-11-29-22(30-12-18)24(25,26)27/h7-12,15H,5-6,13H2,1-4H3,(H,31,33)/t15-/m1/s1 GWFQILAPUSJPLG-OAHLLOKOSA-N 320046 3-{[1- (dimethylamino) cyclopropyl] methoxy}- 5-(5-methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 213::US10202369, Example 213::US10472354, Example 213 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320046 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320046&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397636 384223322 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632422 C[C@@H](NC(=O)c1cc(OC2CC3(C2)CN(C)C3)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C25H26F3N5O2S/c1-14-9-29-22(36-14)17-4-16(5-19(6-17)35-20-7-24(8-20)12-33(3)13-24)21(34)32-15(2)18-10-30-23(31-11-18)25(26,27)28/h4-6,9-11,15,20H,7-8,12-13H2,1-3H3,(H,32,34)/t15-/m1/s1 HKONVGJPBICXCZ-OAHLLOKOSA-N 320047 3-[(2-methyl-2- azaspiro [3.3]hept- 6-yl)oxy]-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 214::US10202369, Example 214::US10472354, Example 214 P2X purinoceptor 3 Homo sapiens 47.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320047 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320047&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397792 384223323 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632424 C[C@@H](NC(=O)c1cc(OC2CCN(C)CC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)F InChI=1S/C24H27F2N5O2S/c1-14-11-29-24(34-14)17-8-16(9-20(10-17)33-19-4-6-31(3)7-5-19)23(32)30-15(2)18-12-27-22(21(25)26)28-13-18/h8-13,15,19,21H,4-7H2,1-3H3,(H,30,32)/t15-/m1/s1 XUPWDJXPNRZNKL-OAHLLOKOSA-N 320048 N-{[(1R)-1-[2- (difluoromethyl) pyrimidin-5- yl]ethyl}-3-[(1- methylpiperidin- 4-yl)oxy]-5-(5- methyl-1,3- thiazol-2- yl)benzamide::US10174016, Example 215::US10202369, Example 215 P2X purinoceptor 3 Homo sapiens 16.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320048 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320048&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397133 384223324 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632426 C[C@@H](NC(=O)c1cc(O[C@@H]2C[C@@H]3CC[C@H](C2)N3C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C26H28F3N5O2S/c1-14-11-30-24(37-14)17-6-16(7-21(8-17)36-22-9-19-4-5-20(10-22)34(19)3)23(35)33-15(2)18-12-31-25(32-13-18)26(27,28)29/h6-8,11-13,15,19-20,22H,4-5,9-10H2,1-3H3,(H,33,35)/t15-,19-,20+,22+/m1/s1 BLUSEIUVKSVVTE-DZUANBCISA-N 320049 3-{[(3-endo)-8- methyl-8- azabicyclo[3.2.1] oct-3-yl]oxy}-5- (5-methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 216::US10202369, Example 216::US10472354, Example 216 P2X purinoceptor 3 Homo sapiens 14.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320049 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320049&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397314 384223325 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632428 C[C@@H](NC(=O)c1cc(O[C@H]2C[C@@H]3CC[C@H](C2)N3C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C26H28F3N5O2S/c1-14-11-30-24(37-14)17-6-16(7-21(8-17)36-22-9-19-4-5-20(10-22)34(19)3)23(35)33-15(2)18-12-31-25(32-13-18)26(27,28)29/h6-8,11-13,15,19-20,22H,4-5,9-10H2,1-3H3,(H,33,35)/t15-,19-,20+,22-/m1/s1 BLUSEIUVKSVVTE-BWKKGPAXSA-N 320050 3-{[(3-exo)-8- methyl-8- azabicyclo[3.2.1] oct-3-yl]oxy}- 5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 217::US10202369, Example 217::US10472354, Example 217 P2X purinoceptor 3 Homo sapiens 25.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320050 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320050&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397314 384223326 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632430 C[C@@H](NC(=O)c1cc(O[C@@H]2CC[C@H]3[C@H]2OCCN3C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C26H28F3N5O3S/c1-14-11-30-24(38-14)17-8-16(23(35)33-15(2)18-12-31-25(32-13-18)26(27,28)29)9-19(10-17)37-21-5-4-20-22(21)36-7-6-34(20)3/h8-13,15,20-22H,4-7H2,1-3H3,(H,33,35)/t15-,20+,21-,22-/m1/s1 FEZSJTOXTJNSGQ-WWGKXEARSA-N 320051 3-{[(4aS,7R, 7aR)-4- methyloctahydro- cyclopenta [b][1,4] oxazin-7-yl] oxy}-5- (5-methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 218::US10202369, Example 218::US10472354, Example 218 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320051 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320051&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397834 384223327 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632432 C[C@@H](NC(=O)c1cc(O[C@H]2CC[C@H]3[C@H]2OCCN3C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C26H28F3N5O3S/c1-14-11-30-24(38-14)17-8-16(23(35)33-15(2)18-12-31-25(32-13-18)26(27,28)29)9-19(10-17)37-21-5-4-20-22(21)36-7-6-34(20)3/h8-13,15,20-22H,4-7H2,1-3H3,(H,33,35)/t15-,20+,21+,22-/m1/s1 FEZSJTOXTJNSGQ-NSEXGNSCSA-N 320052 3-{[(4aS,7S, 7aR)-4- methylocta- hydro- cyclopenta[b] [1,4]oxazin- 7-yl]oxy}-5- (5-methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 219::US10202369, Example 219::US10472354, Example 219 P2X purinoceptor 3 Homo sapiens 2.00 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320052 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320052&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397597 384223328 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632434 C[C@@H](NC(=O)c1cc(OC2CCCN(C)C2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H26F3N5O2S/c1-14-10-28-22(35-14)17-7-16(8-20(9-17)34-19-5-4-6-32(3)13-19)21(33)31-15(2)18-11-29-23(30-12-18)24(25,26)27/h7-12,15,19H,4-6,13H2,1-3H3,(H,31,33)/t15-,19?/m1/s1 DNVWWBHMIGZIMX-NYRJJRHWSA-N 322409 3-[(1-methylpiperidin-3-yl)oxy]-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10183937, Example 220::US10202369, Example 220::US10472354, Example 221 P2X purinoceptor 3 Homo sapiens 62.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322409 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322409&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397678 384225471 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632436 C[C@H](NC(=O)c1cc(OC2CCCN(C)C2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H26F3N5O2S/c1-14-10-28-22(35-14)17-7-16(8-20(9-17)34-19-5-4-6-32(3)13-19)21(33)31-15(2)18-11-29-23(30-12-18)24(25,26)27/h7-12,15,19H,4-6,13H2,1-3H3,(H,31,33)/t15-,19?/m0/s1 DNVWWBHMIGZIMX-FUKCDUGKSA-N 322410 US10183937, Example 221::US10202369, Example 221::US10472354, Example 220 P2X purinoceptor 3 Homo sapiens 26.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322410 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322410&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 138375409 384225472 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632438 C[C@@H](NC(=O)c1cc(OC2CCN(C)C(C2)C(F)(F)F)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C25H25F6N5O2S/c1-13-10-32-22(39-13)16-6-15(21(37)35-14(2)17-11-33-23(34-12-17)25(29,30)31)7-19(8-16)38-18-4-5-36(3)20(9-18)24(26,27)28/h6-8,10-12,14,18,20H,4-5,9H2,1-3H3,(H,35,37)/t14-,18?,20?/m1/s1 ALJCLRFXPKVCLC-FHTBDLFWSA-N 322411 3-(5-methyl-1,3-thiazol-2-yl)-5-{[1-methyl-2-(trifluoromethyl)piperidin-4-yl]oxy}-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10183937, Example 222::US10202369, Example 222::US10472354, Example 223 P2X purinoceptor 3 Homo sapiens 4.00 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322411 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322411&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397819 384225473 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632440 C[C@H](NC(=O)c1cc(OC2CCN(C)C(C2)C(F)(F)F)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C25H25F6N5O2S/c1-13-10-32-22(39-13)16-6-15(21(37)35-14(2)17-11-33-23(34-12-17)25(29,30)31)7-19(8-16)38-18-4-5-36(3)20(9-18)24(26,27)28/h6-8,10-12,14,18,20H,4-5,9H2,1-3H3,(H,35,37)/t14-,18?,20?/m0/s1 ALJCLRFXPKVCLC-KLOIUYPJSA-N 322412 US10183937, Example 223::US10202369, Example 223::US10472354, Example 222 P2X purinoceptor 3 Homo sapiens 3.00 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322412 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322412&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 138375410 384225474 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632442 CC(C)N1CCC(CC1)Oc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1ccc(nn1)C(F)(F)F InChI=1S/C26H30F3N5O2S/c1-15(2)34-9-7-20(8-10-34)36-21-12-18(11-19(13-21)25-30-14-16(3)37-25)24(35)31-17(4)22-5-6-23(33-32-22)26(27,28)29/h5-6,11-15,17,20H,7-10H2,1-4H3,(H,31,35)/t17-/m1/s1 KRNISEGUXIGIEE-QGZVFWFLSA-N 320057 3-(5-Methyl-1,3-thiazol-2-yl)-5-{[1-(propan-2-yl)piperidin-4-yl]oxy}-N-{(1R)-1-[6-(trifluoromethyl)pyridazin-3-yl]ethyl}benzamide::US10174016, Example 224::US10202369, Example 224::US10472354, Example 224 P2X purinoceptor 3 Homo sapiens 9.00 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320057 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320057&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397429 384223331 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632444 CC(C)N1CC[C@@H](C1)Oc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C25H28F3N5O2S/c1-14(2)33-6-5-20(13-33)35-21-8-17(7-18(9-21)23-29-10-15(3)36-23)22(34)32-16(4)19-11-30-24(31-12-19)25(26,27)28/h7-12,14,16,20H,5-6,13H2,1-4H3,(H,32,34)/t16-,20+/m1/s1 AIBFTYSUMUVEOU-UZLBHIALSA-N 320058 3-(5-methyl- 1,3-thiazol- 2-yl)-5- {[(3S)-1- (propan-2- yl)pyrrolidin- 3-yl]oxy}-N- {(1R)-1- [2-(trifluoro- methyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 225::US10202369, Example 225::US10472354, Example 225 P2X purinoceptor 3 Homo sapiens 16.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320058 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320058&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397786 384223332 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632446 COC(=O)N1CCC(CC1)Oc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C25H26F3N5O4S/c1-14-11-29-22(38-14)17-8-16(9-20(10-17)37-19-4-6-33(7-5-19)24(35)36-3)21(34)32-15(2)18-12-30-23(31-13-18)25(26,27)28/h8-13,15,19H,4-7H2,1-3H3,(H,32,34)/t15-/m1/s1 XKGQQPBORAHPPR-OAHLLOKOSA-N 320059 Methyl 4-[3-(5-methyl-1,3-thiazol-2-yl)-5-({(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}carbamoyl)phenoxy]piperidine-1-carboxylate::US10174016, Example 226::US10202369, Example 226::US10472354, Example 226 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320059 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320059&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397135 384223333 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632448 CCOC(=O)N1CCC(CC1)Oc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C26H28F3N5O4S/c1-4-37-25(36)34-7-5-20(6-8-34)38-21-10-17(9-18(11-21)23-30-12-15(2)39-23)22(35)33-16(3)19-13-31-24(32-14-19)26(27,28)29/h9-14,16,20H,4-8H2,1-3H3,(H,33,35)/t16-/m1/s1 VLNWCOYPKWPZPZ-MRXNPFEDSA-N 320060 Ethyl 4-[3-(5-methyl-1,3-thiazol-2-yl)-5-({(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}carbamoyl)phenoxy]piperidine-1-carboxylate::US10174016, Example 227::US10202369, Example 227::US10472354, Example 227 P2X purinoceptor 3 Homo sapiens 13.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320060 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320060&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397225 384223334 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632450 CCOC(=O)N1CC[C@@H](C1)Oc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C25H26F3N5O4S/c1-4-36-24(35)33-6-5-19(13-33)37-20-8-16(7-17(9-20)22-29-10-14(2)38-22)21(34)32-15(3)18-11-30-23(31-12-18)25(26,27)28/h7-12,15,19H,4-6,13H2,1-3H3,(H,32,34)/t15-,19+/m1/s1 ZKABVOKJBCLEBM-BEFAXECRSA-N 320061 Ethyl (3S)-3-[3-(5-methyl-1,3-thiazol-2-yl)-5-({(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}carbamoyl)phenoxy]pyrrolidine-1-carboxylate::US10174016, Example 228::US10202369, Example 228::US10472354, Example 228 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320061 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320061&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134338446 384223335 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632452 CC(C)N1CC(C1)Oc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C24H26F3N5O2S/c1-13(2)32-11-20(12-32)34-19-6-16(5-17(7-19)22-28-8-14(3)35-22)21(33)31-15(4)18-9-29-23(30-10-18)24(25,26)27/h5-10,13,15,20H,11-12H2,1-4H3,(H,31,33)/t15-/m1/s1 ZGCTZBYNIOVVEC-OAHLLOKOSA-N 320062 3-(5-Methyl-1,3-thiazol-2-yl)-5-{[1-(propan-2-yl)azetidin-3-yl]oxy}-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 229::US10202369, Example 229::US10472354, Example 229 P2X purinoceptor 3 Homo sapiens 44.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320062 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320062&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397633 384223336 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632454 CC(O)C(C)Oc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1ccc(nn1)C(F)(F)F InChI=1S/C22H23F3N4O3S/c1-11-10-26-21(33-11)16-7-15(8-17(9-16)32-14(4)13(3)30)20(31)27-12(2)18-5-6-19(29-28-18)22(23,24)25/h5-10,12-14,30H,1-4H3,(H,27,31)/t12-,13?,14?/m1/s1 LMHZXBDHIYABCN-IYXRBSQSSA-N 320016 Trans Isomer 1; 3- {[3-hydroxybutan- 2-yl]oxy}-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl}benzamide::US10174016, Example 183::US10202369, Example 230::US10472354, Example 231 P2X purinoceptor 3 Homo sapiens 2.00 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320016 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320016&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397175 384223296 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632456 CC(O)C(C)Oc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@@H](C)c1ccc(nn1)C(F)(F)F InChI=1S/C22H23F3N4O3S/c1-11-10-26-21(33-11)16-7-15(8-17(9-16)32-14(4)13(3)30)20(31)27-12(2)18-5-6-19(29-28-18)22(23,24)25/h5-10,12-14,30H,1-4H3,(H,27,31)/t12-,13?,14?/m0/s1 LMHZXBDHIYABCN-HSBZDZAISA-N 322420 US10183937, Example 231::US10202369, Example 231::US10472354, Example 230 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322420 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322420&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 138375411 384225482 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632458 C[C@@H](NC(=O)c1cc(OC2CCS(=O)(=O)CC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H23F3N4O4S2/c1-13-10-27-21(35-13)16-7-15(8-19(9-16)34-18-3-5-36(32,33)6-4-18)20(31)30-14(2)17-11-28-22(29-12-17)23(24,25)26/h7-12,14,18H,3-6H2,1-2H3,(H,30,31)/t14-/m1/s1 JTWSIDWRGZSZAA-CQSZACIVSA-N 320065 3-[(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)oxy]-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 232::US10202369, Example 232::US10472354, Example 232 P2X purinoceptor 3 Homo sapiens 13.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320065 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320065&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397851 384223339 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632460 C[C@@H](NC(=O)c1cc(OC2CCS(=O)(=O)CC2)cc(c1)-c1ncc(C)s1)c1ccc(nc1)C(F)(F)F InChI=1S/C24H24F3N3O4S2/c1-14-12-29-23(35-14)18-9-17(10-20(11-18)34-19-5-7-36(32,33)8-6-19)22(31)30-15(2)16-3-4-21(28-13-16)24(25,26)27/h3-4,9-13,15,19H,5-8H2,1-2H3,(H,30,31)/t15-/m1/s1 BRFDVYQZWOBZCT-OAHLLOKOSA-N 320066 3-[(1,1- dioxidotetrahydro- 2H-thiopyran-4- yl)oxy]-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[6- (trifluoromethyl) pyridin-3-yl]ethyl} benzamide::US10174016, Example 233::US10202369, Example 233::US10472354, Example 233 P2X purinoceptor 3 Homo sapiens 16.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320066 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320066&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397139 384223340 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632462 CCc1cnc(s1)-c1cc(OC2CCOCC2)cc(c1)C(=O)N[C@H](C)c1cnc(C)cn1 InChI=1S/C24H28N4O3S/c1-4-21-13-27-24(32-21)18-9-17(10-20(11-18)31-19-5-7-30-8-6-19)23(29)28-16(3)22-14-25-15(2)12-26-22/h9-14,16,19H,4-8H2,1-3H3,(H,28,29)/t16-/m1/s1 DYONOLZVTXITOM-MRXNPFEDSA-N 320067 3-(5-ethyl-1,3- thiazol-2-yl)-N- [(1R)-1-(5- methylpyrazin-2- yl)ethyl]-5- (tetrahydro-2H- pyran-4- yloxy)benzamide::US10174016, Example 234::US10202369, Example 234::US10472354, Example 234 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320067 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320067&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397540 384223341 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632464 CCc1cnc(s1)-c1cc(OC2CCOCC2)cc(c1)C(=O)NCc1ccc(C)nn1 InChI=1S/C23H26N4O3S/c1-3-21-14-25-23(31-21)17-10-16(11-20(12-17)30-19-6-8-29-9-7-19)22(28)24-13-18-5-4-15(2)26-27-18/h4-5,10-12,14,19H,3,6-9,13H2,1-2H3,(H,24,28) BZFPOECMUNEZDH-UHFFFAOYSA-N 320068 3-(5-ethyl-1,3- thiazol-2-yl)-N-[(6- methylpyridazin-3- yl)methyl]-5- (tetrahydro-2H- pyran-4- yloxy)benzamide::US10174016, Example 235::US10202369, Example 235::US10472354, Example 235 P2X purinoceptor 3 Homo sapiens 18.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320068 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320068&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397197 384223342 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632466 C[C@@H](NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(s1)C1CCC1)c1cnc(C)cn1 InChI=1S/C26H30N4O3S/c1-16-13-28-23(14-27-16)17(2)30-25(31)19-10-20(26-29-15-24(34-26)18-4-3-5-18)12-22(11-19)33-21-6-8-32-9-7-21/h10-15,17-18,21H,3-9H2,1-2H3,(H,30,31)/t17-/m1/s1 QOZNFPLCSPWJRX-QGZVFWFLSA-N 320069 3-(5-cyclobutyl- 1,3-thiazol-2-yl)- N-[(1R)-1-(5- methylpyrazin-2- yl)ethyl]-5- (tetrahydro-2H- pyran-4- yloxy)benzamide::US10174016, Example 236::US10202369, Example 236::US10472354, Example 236 P2X purinoceptor 3 Homo sapiens 76.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320069 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320069&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397529 384223343 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632468 Cc1ccc(CNC(=O)c2cc(OC3CCOCC3)cc(c2)-c2ncc(s2)C2CCC2)nn1 InChI=1S/C25H28N4O3S/c1-16-5-6-20(29-28-16)14-26-24(30)18-11-19(25-27-15-23(33-25)17-3-2-4-17)13-22(12-18)32-21-7-9-31-10-8-21/h5-6,11-13,15,17,21H,2-4,7-10,14H2,1H3,(H,26,30) KYDTWNODFNIYNY-UHFFFAOYSA-N 320070 3-(5-cyclobutyl- 1,3-thiazol-2-yl)- N-[(6- methylpyridazin-3- yl)methyl]-5- (tetrahydro-2H- pyran-4- yloxy)benzamide::US10174016, Example 237::US10202369, Example 237::US10472354, Example 237 P2X purinoceptor 3 Homo sapiens 177 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320070 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320070&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397323 384223344 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632470 C[C@@H](NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(s1)C1CCC1)c1cnc(nc1)C(F)(F)F InChI=1S/C26H27F3N4O3S/c1-15(19-12-31-25(32-13-19)26(27,28)29)33-23(34)17-9-18(24-30-14-22(37-24)16-3-2-4-16)11-21(10-17)36-20-5-7-35-8-6-20/h9-16,20H,2-8H2,1H3,(H,33,34)/t15-/m1/s1 KTFAMKPHNDUKLL-OAHLLOKOSA-N 320071 3-(5-cyclobutyl- 1,3-thiazol-2-yl)-5- (tetrahydro-2H- pyran-4-yloxy)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 238::US10202369, Example 238::US10472354, Example 238 P2X purinoceptor 3 Homo sapiens 38.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320071 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320071&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397176 384223345 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632472 C[C@H](NC(=O)c1cc(OC[C@H]2CCOC2)cc(c1)-c1ncc(s1)C1CCC1)c1cnc(nc1)C(F)(F)F InChI=1S/C26H27F3N4O3S/c1-15(20-10-31-25(32-11-20)26(27,28)29)33-23(34)18-7-19(24-30-12-22(37-24)17-3-2-4-17)9-21(8-18)36-14-16-5-6-35-13-16/h7-12,15-17H,2-6,13-14H2,1H3,(H,33,34)/t15-,16-/m0/s1 JWRPHAGJMIAQMD-HOTGVXAUSA-N 320072 3-(5-cyclobutyl- 1,3-thiazol-2-yl)-5- [(3S)- tetrahydrofuran-3- ylmethoxy]-N- {(1S)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 239::US10202369, Example 239::US10472354, Example 239 P2X purinoceptor 3 Homo sapiens 1420 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320072 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320072&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397719 384223346 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632474 CCc1cnc(s1)-c1cc(O[C@@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1ccc(C)nn1 InChI=1S/C23H26N4O3S/c1-4-20-12-24-23(31-20)17-9-16(10-19(11-17)30-18-7-8-29-13-18)22(28)25-15(3)21-6-5-14(2)26-27-21/h5-6,9-12,15,18H,4,7-8,13H2,1-3H3,(H,25,28)/t15-,18-/m1/s1 OXXUGGORGDKECE-CRAIPNDOSA-N 320073 3-(5-ethyl-1,3- thiazol-2-yl)-N- [(1R)-1-(6- methylpyridazin-3- yl)ethyl]-5-[(3R)- tetrahydrofuran-3- yloxy]benzamide::US10174016, Example 240::US10202369, Example 249::US10472354, Example 240 P2X purinoceptor 3 Homo sapiens 12.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320073 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320073&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397178 384223347 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632476 CCc1cnc(s1)-c1cc(O[C@@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1cnc(C)cn1 InChI=1S/C23H26N4O3S/c1-4-20-11-26-23(31-20)17-7-16(8-19(9-17)30-18-5-6-29-13-18)22(28)27-15(3)21-12-24-14(2)10-25-21/h7-12,15,18H,4-6,13H2,1-3H3,(H,27,28)/t15-,18-/m1/s1 GGGFDTSSCKHCGY-CRAIPNDOSA-N 320074 3-(5-ethyl-1,3- thiazol-2-yl)-N- [(1R)-1-(5- methylpyrazin-2- yl)ethyl]-5-[(3R)- tetrahydrofuran-3- yloxy]benzamide::US10174016, Example 241::US10202369, Example 241::US10472354, Example 241 P2X purinoceptor 3 Homo sapiens 12.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320074 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320074&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397675 384223348 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632478 CCc1cnc(s1)-c1cc(O[C@@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C23H23F3N4O3S/c1-3-19-11-27-21(34-19)15-6-14(7-18(8-15)33-17-4-5-32-12-17)20(31)30-13(2)16-9-28-22(29-10-16)23(24,25)26/h6-11,13,17H,3-5,12H2,1-2H3,(H,30,31)/t13-,17-/m1/s1 CPHCWMUXIASQAI-CXAGYDPISA-N 320075 3-(5-ethyl-1,3- thiazol-2-yl)-5- [(3R)- tetrahydrofuran-3- yloxy]-N-{(1R)-1- [2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 242::US10202369, Example 242::US10472354, Example 242 P2X purinoceptor 3 Homo sapiens 2.00 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320075 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320075&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397732 384223349 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632480 C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(s1)C1CCC1)c1ccc(C)nn1 InChI=1S/C25H28N4O3S/c1-15-6-7-22(29-28-15)16(2)27-24(30)18-10-19(12-21(11-18)32-20-8-9-31-14-20)25-26-13-23(33-25)17-4-3-5-17/h6-7,10-13,16-17,20H,3-5,8-9,14H2,1-2H3,(H,27,30)/t16-,20-/m1/s1 GBDWWYIZWHGLEN-OXQOHEQNSA-N 320076 3-(5-cyclobutyl- 1,3-thiazol-2-yl)- N-[(1R)-1-(6- methylpyridazin-3- yl)ethyl]-5-[(3R)- tetrahydrofuran-3- yloxy]benzamide::US10174016, Example 243::US10202369, Example 243::US10472354, Example 243 P2X purinoceptor 3 Homo sapiens 117 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320076 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320076&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397824 384223350 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632482 C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(s1)C1CCC1)c1cnc(C)cn1 InChI=1S/C25H28N4O3S/c1-15-11-27-22(12-26-15)16(2)29-24(30)18-8-19(10-21(9-18)32-20-6-7-31-14-20)25-28-13-23(33-25)17-4-3-5-17/h8-13,16-17,20H,3-7,14H2,1-2H3,(H,29,30)/t16-,20-/m1/s1 FVGXVLFIHFQXPP-OXQOHEQNSA-N 320077 3-(5-cyclobutyl- 1,3-thiazol-2-yl)- N-[(1R)-1-(5- methylpyrazin-2- yl)ethyl]-5-[(3R)- tetrahydrofuran-3- yloxy]benzamide::US10174016, Example 244::US10202369, Example 244::US10472354, Example 244 P2X purinoceptor 3 Homo sapiens 75.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320077 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320077&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397416 384223351 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632484 C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(s1)C1CCC1)c1cnc(nc1)C(F)(F)F InChI=1S/C25H25F3N4O3S/c1-14(18-10-30-24(31-11-18)25(26,27)28)32-22(33)16-7-17(9-20(8-16)35-19-5-6-34-13-19)23-29-12-21(36-23)15-3-2-4-15/h7-12,14-15,19H,2-6,13H2,1H3,(H,32,33)/t14-,19-/m1/s1 IDGMWIXZIVCDCF-AUUYWEPGSA-N 320078 3-(5-cyclobutyl- 1,3-thiazol-2-yl)-5- [(3R)- tetrahydrofuran-3- yloxy]-N-{(1R)-1- [2-(trifluoromethyl) pyrimidin-5-yl] ethyl}benzamide::US10174016, Example 245::US10202369, Example 245::US10472354, Example 245 P2X purinoceptor 3 Homo sapiens 34.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320078 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320078&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397471 384223352 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632486 CC(C)c1cnc(s1)-c1cc(O[C@@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1ccc(C)nn1 InChI=1S/C24H28N4O3S/c1-14(2)22-12-25-24(32-22)18-9-17(10-20(11-18)31-19-7-8-30-13-19)23(29)26-16(4)21-6-5-15(3)27-28-21/h5-6,9-12,14,16,19H,7-8,13H2,1-4H3,(H,26,29)/t16-,19-/m1/s1 AZADLHFQZQVHQV-VQIMIIECSA-N 320079 N-[(1R)-1-(6- methylpyridazin-3- yl)ethyl]-3-[5- (propan-2-yl)-1,3- thiazol-2-yl]-5- [(3R)- tetrahydrofuran-3- yloxy]benzamide::US10174016, Example 246::US10202369, Example 246::US10472354, Example 246 P2X purinoceptor 3 Homo sapiens 266 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320079 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320079&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397745 384223353 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632488 CC(C)c1cnc(s1)-c1cc(O[C@@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1cnc(C)cn1 InChI=1S/C24H28N4O3S/c1-14(2)22-12-27-24(32-22)18-7-17(8-20(9-18)31-19-5-6-30-13-19)23(29)28-16(4)21-11-25-15(3)10-26-21/h7-12,14,16,19H,5-6,13H2,1-4H3,(H,28,29)/t16-,19-/m1/s1 ULUQVVVXKLITBV-VQIMIIECSA-N 320080 N-[(1R)-1-(5- methylpyrazin-2- yl)ethyl]-3-[5- (propan-2-yl)-1,3- thiazol-2-yl]-5- [(3R)- tetrahydrofuran-3- yloxy]benzamide::US10174016, Example 247::US10202369, Example 247::US10472354, Example 247 P2X purinoceptor 3 Homo sapiens 205 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320080 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320080&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397213 384223354 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632490 CC(C)c1cnc(s1)-c1cc(O[C@@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C24H25F3N4O3S/c1-13(2)20-11-28-22(35-20)16-6-15(7-19(8-16)34-18-4-5-33-12-18)21(32)31-14(3)17-9-29-23(30-10-17)24(25,26)27/h6-11,13-14,18H,4-5,12H2,1-3H3,(H,31,32)/t14-,18-/m1/s1 COCLYUAEQYUAPW-RDTXWAMCSA-N 320081 3-[5-(propan-2-yl)- 1,3-thiazol-2-yl]-5- [(3R)- tetrahydrofuran-3- yloxy]-N-{(1R)-1- [2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 248::US10202369, Example 248::US10472354, Example 248 P2X purinoceptor 3 Homo sapiens 44.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320081 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320081&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397577 384223355 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632492 CCc1cnc(s1)-c1cc(O[C@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1ccc(C)nn1 InChI=1S/C23H26N4O3S/c1-4-20-12-24-23(31-20)17-9-16(10-19(11-17)30-18-7-8-29-13-18)22(28)25-15(3)21-6-5-14(2)26-27-21/h5-6,9-12,15,18H,4,7-8,13H2,1-3H3,(H,25,28)/t15-,18+/m1/s1 OXXUGGORGDKECE-QAPCUYQASA-N 320082 3-(5-ethyl-1,3- thiazol-2-yl)-N- [(1R)-1-(6- methylpyridazin-3- yl)ethyl]-5-[(3S)- tetrahydrofuran-3- yloxy]benzamide::US10174016, Example 249::US10472354, Example 249 P2X purinoceptor 3 Homo sapiens 11.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320082 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320082&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397606 384223356 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632494 CCc1cnc(s1)-c1cc(O[C@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1cnc(C)cn1 InChI=1S/C23H26N4O3S/c1-4-20-11-26-23(31-20)17-7-16(8-19(9-17)30-18-5-6-29-13-18)22(28)27-15(3)21-12-24-14(2)10-25-21/h7-12,15,18H,4-6,13H2,1-3H3,(H,27,28)/t15-,18+/m1/s1 GGGFDTSSCKHCGY-QAPCUYQASA-N 320083 3-(5-ethyl-1,3- thiazol-2-yl)-N- [(1R)-1-(5- methylpyrazin-2- yl)ethyl]-5-[(3S)- tetrahydrofuran-3- yloxy]benzamide::US10174016, Example 250::US10202369, Example 250::US10472354, Example 250 P2X purinoceptor 3 Homo sapiens 15.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320083 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320083&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397653 384223357 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632496 CCc1cnc(s1)-c1cc(O[C@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C23H23F3N4O3S/c1-3-19-11-27-21(34-19)15-6-14(7-18(8-15)33-17-4-5-32-12-17)20(31)30-13(2)16-9-28-22(29-10-16)23(24,25)26/h6-11,13,17H,3-5,12H2,1-2H3,(H,30,31)/t13-,17+/m1/s1 CPHCWMUXIASQAI-DYVFJYSZSA-N 320084 3-(5-ethyl-1,3- thiazol-2-yl)-5- [(3S)- tetrahydrofuran-3- yloxy]-N-{(1R)-1- [2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 251::US10202369, Example 251::US10472354, Example 251 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320084 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320084&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397624 384223358 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632498 C[C@@H](NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(s1)C1CCC1)c1ccc(C)nn1 InChI=1S/C25H28N4O3S/c1-15-6-7-22(29-28-15)16(2)27-24(30)18-10-19(12-21(11-18)32-20-8-9-31-14-20)25-26-13-23(33-25)17-4-3-5-17/h6-7,10-13,16-17,20H,3-5,8-9,14H2,1-2H3,(H,27,30)/t16-,20+/m1/s1 GBDWWYIZWHGLEN-UZLBHIALSA-N 320085 3-(5-cyclobutyl- 1,3-thiazol-2-yl)- N-[(1R)-1-(6- methylpyridazin-3- yl)ethyl]-5-[(3S)- tetrahydrofuran-3- yloxy]benzamide::US10174016, Example 252::US10202369, Example 252::US10472354, Example 252 P2X purinoceptor 3 Homo sapiens 75.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320085 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320085&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397825 384223359 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632500 C[C@@H](NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(s1)C1CCC1)c1cnc(C)cn1 InChI=1S/C25H28N4O3S/c1-15-11-27-22(12-26-15)16(2)29-24(30)18-8-19(10-21(9-18)32-20-6-7-31-14-20)25-28-13-23(33-25)17-4-3-5-17/h8-13,16-17,20H,3-7,14H2,1-2H3,(H,29,30)/t16-,20+/m1/s1 FVGXVLFIHFQXPP-UZLBHIALSA-N 320086 3-(5-cyclobutyl- 1,3-thiazol-2-yl)- N-[(1R)-1-(5- methylpyrazin-2- yl)ethyl]-5-[(3S)- tetrahydrofuran-3- yloxy]benzamide::US10174016, Example 253::US10202369, Example 253::US10472354, Example 253 P2X purinoceptor 3 Homo sapiens 99.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320086 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320086&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397513 384223360 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632502 C[C@@H](NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(s1)C1CCC1)c1cnc(nc1)C(F)(F)F InChI=1S/C25H25F3N4O3S/c1-14(18-10-30-24(31-11-18)25(26,27)28)32-22(33)16-7-17(9-20(8-16)35-19-5-6-34-13-19)23-29-12-21(36-23)15-3-2-4-15/h7-12,14-15,19H,2-6,13H2,1H3,(H,32,33)/t14-,19+/m1/s1 IDGMWIXZIVCDCF-KUHUBIRLSA-N 320087 3-(5-cyclobutyl- 1,3-thiazol-2-yl)-5- [(3S)- tetrahydrofuran-3- yloxy]-N-{(1R)-1- [2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 254::US10202369, Example 254::US10472354, Example 254 P2X purinoceptor 3 Homo sapiens 28.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320087 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320087&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397641 384223361 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632504 CC(C)c1cnc(s1)-c1cc(O[C@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1ccc(C)nn1 InChI=1S/C24H28N4O3S/c1-14(2)22-12-25-24(32-22)18-9-17(10-20(11-18)31-19-7-8-30-13-19)23(29)26-16(4)21-6-5-15(3)27-28-21/h5-6,9-12,14,16,19H,7-8,13H2,1-4H3,(H,26,29)/t16-,19+/m1/s1 AZADLHFQZQVHQV-APWZRJJASA-N 320088 N-[(1R)-1-(6- methylpyridazin-3- yl)ethyl]-3-[5- (propan-2-yl)-1,3- thiazol-2-yl]-5- [(3S)- tetrahydrofuran-3- yloxy]benzamide::US10174016, Example 255::US10202369, Example 255::US10472354, Example 255 P2X purinoceptor 3 Homo sapiens 254 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320088 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320088&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397188 384223362 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632568 C[C@@H](NC(=O)c1cc(OC[C@@H]2CCCO2)cc(c1)-c1ncc(s1)C1CCC1)c1cnc(nc1)C(F)(F)F InChI=1S/C26H27F3N4O3S/c1-15(19-11-31-25(32-12-19)26(27,28)29)33-23(34)17-8-18(24-30-13-22(37-24)16-4-2-5-16)10-21(9-17)36-14-20-6-3-7-35-20/h8-13,15-16,20H,2-7,14H2,1H3,(H,33,34)/t15-,20+/m1/s1 ZERBIURYMMOJBU-QRWLVFNGSA-N 320120 3-(5-cyclobutyl- 1,3-thiazol-2-yl)-5- [(2S)- tetrahydrofuran-2- ylmethoxy]-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 287::US10202369, Example 287::US10472354, Example 287 P2X purinoceptor 3 Homo sapiens 35.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320120 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320120&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397159 384223394 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632570 CC(C)c1cnc(s1)-c1cc(OC[C@@H]2CCCO2)cc(c1)C(=O)N[C@H](C)c1ccc(C)nn1 InChI=1S/C25H30N4O3S/c1-15(2)23-13-26-25(33-23)19-10-18(11-21(12-19)32-14-20-6-5-9-31-20)24(30)27-17(4)22-8-7-16(3)28-29-22/h7-8,10-13,15,17,20H,5-6,9,14H2,1-4H3,(H,27,30)/t17-,20+/m1/s1 UAMKMSQRQBQFJK-XLIONFOSSA-N 320121 N-[(1R)-1-(6- methylpyridazin-3- yl)ethyl]-3-[5- (propan-2-yl)-1,3- thiazol-2-yl]-5- [(2S)- tetrahydrofuran-2- ylmethoxy] benzamide::US10174016, Example 288::US10202369, Example 288::US10472354, Example 288 P2X purinoceptor 3 Homo sapiens 150 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320121 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320121&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397738 384223395 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632572 CC(C)c1cnc(s1)-c1cc(OC[C@@H]2CCCO2)cc(c1)C(=O)N[C@H](C)c1cnc(C)cn1 InChI=1S/C25H30N4O3S/c1-15(2)23-13-28-25(33-23)19-8-18(9-21(10-19)32-14-20-6-5-7-31-20)24(30)29-17(4)22-12-26-16(3)11-27-22/h8-13,15,17,20H,5-7,14H2,1-4H3,(H,29,30)/t17-,20+/m1/s1 CNKRLRNKYMMPAE-XLIONFOSSA-N 320122 N-[(1R)-1-(5- methylpyrazin-2- yl)ethyl]-3-[5- (propan-2-yl)-1,3- thiazol-2-yl]-5- [(2S)- tetrahydrofuran-2- ylmethoxy]benzamide::US10174016, Example 289::US10202369, Example 289::US10472354, Example 289 P2X purinoceptor 3 Homo sapiens 192 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320122 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320122&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397419 384223396 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632574 CC(C)c1cnc(s1)-c1cc(OC[C@@H]2CCCO2)cc(c1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C25H27F3N4O3S/c1-14(2)21-12-29-23(36-21)17-7-16(8-20(9-17)35-13-19-5-4-6-34-19)22(33)32-15(3)18-10-30-24(31-11-18)25(26,27)28/h7-12,14-15,19H,4-6,13H2,1-3H3,(H,32,33)/t15-,19+/m1/s1 KTCCKJLURHRITN-BEFAXECRSA-N 320123 3-[5-(propan-2-yl)- 1,3-thiazol-2-yl]-5- [(2S)- tetrahydrofuran-2- ylmethoxy]-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 290::US10472354, Example 290 P2X purinoceptor 3 Homo sapiens 31.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320123 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320123&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397222 384223397 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632576 C[C@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C22H21F3N4O3S/c1-12-8-26-20(33-12)15-5-14(6-18(7-15)32-17-3-4-31-11-17)19(30)29-13(2)16-9-27-21(28-10-16)22(23,24)25/h5-10,13,17H,3-4,11H2,1-2H3,(H,29,30)/t13-,17+/m0/s1 GTQPEQGDLVSFJO-SUMWQHHRSA-N 320124 3-(5-methyl-1,3- thiazol-2-yl)-5- [(3R)- tetrahydrofuran-3- yloxy]-N-{(1S)-1- [2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 291::US10202369, Example 291 P2X purinoceptor 3 Homo sapiens 1320 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320124 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320124&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397365 384223398 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632578 CCc1cnc(s1)-c1cc(OC[C@@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1ccc(nn1)C(F)(F)F InChI=1S/C24H25F3N4O3S/c1-3-19-11-28-23(35-19)17-8-16(9-18(10-17)34-13-15-6-7-33-12-15)22(32)29-14(2)20-4-5-21(31-30-20)24(25,26)27/h4-5,8-11,14-15H,3,6-7,12-13H2,1-2H3,(H,29,32)/t14-,15-/m1/s1 PGRAVNCJCWWOPT-HUUCEWRRSA-N 320125 3-(5-ethyl-1,3- thiazol-2-yl)-5- [(3R)- tetrahydrofuran-3- ylmethoxy]-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3-yl] ethyl}benzamide::US10174016, Example 292::US10202369, Example 292 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320125 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320125&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397547 384223399 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632580 CC(C)c1cnc(s1)-c1cc(OC[C@@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1ccc(nn1)C(F)(F)F InChI=1S/C25H27F3N4O3S/c1-14(2)21-11-29-24(36-21)18-8-17(9-19(10-18)35-13-16-6-7-34-12-16)23(33)30-15(3)20-4-5-22(32-31-20)25(26,27)28/h4-5,8-11,14-16H,6-7,12-13H2,1-3H3,(H,30,33)/t15-,16-/m1/s1 ZWFOSAQPAKMJAC-HZPDHXFCSA-N 320126 3-[5-(propan-2-yl)- 1,3-thiazol-2-yl]-5- [(3R)- tetrahydrofuran-3- ylmethoxy]-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl}benzamide::US10174016, Example 293::US10202369, Example 301 P2X purinoceptor 3 Homo sapiens 63.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320126 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320126&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397373 384223400 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632582 CC(C)c1cnc(s1)-c1cc(O[C@@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1ccc(nn1)C(F)(F)F InChI=1S/C24H25F3N4O3S/c1-13(2)20-11-28-23(35-20)16-8-15(9-18(10-16)34-17-6-7-33-12-17)22(32)29-14(3)19-4-5-21(31-30-19)24(25,26)27/h4-5,8-11,13-14,17H,6-7,12H2,1-3H3,(H,29,32)/t14-,17-/m1/s1 ALCUBFBGIYQDIY-RHSMWYFYSA-N 320127 3-[5-(propan-2-yl)- 1,3-thiazol-2-yl]-5- [(3R)- tetrahydrofuran-3- yloxy]-N-{(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl}benzamide::US10174016, Example 294::US10202369, Example 294::US10472354, Example 294 P2X purinoceptor 3 Homo sapiens 101 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320127 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320127&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397844 384223401 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632584 C[C@@H](NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(s1)C1CCC1)c1ccc(nn1)C(F)(F)F InChI=1S/C25H25F3N4O3S/c1-14(20-5-6-22(32-31-20)25(26,27)28)30-23(33)16-9-17(11-19(10-16)35-18-7-8-34-13-18)24-29-12-21(36-24)15-3-2-4-15/h5-6,9-12,14-15,18H,2-4,7-8,13H2,1H3,(H,30,33)/t14-,18+/m1/s1 LCHSLMNVJPMESH-KDOFPFPSSA-N 320128 3-(5-cyclobutyl- 1,3-thiazol-2-yl)-5- [(3S)- tetrahydrofuran-3- yloxy]-N-{(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl}benzamide::US10174016, Example 295::US10202369, Example 295::US10472354, Example 295 P2X purinoceptor 3 Homo sapiens 55.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320128 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320128&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397441 384223402 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632586 CCc1cnc(s1)-c1cc(OC[C@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1ccc(nn1)C(F)(F)F InChI=1S/C24H25F3N4O3S/c1-3-19-11-28-23(35-19)17-8-16(9-18(10-17)34-13-15-6-7-33-12-15)22(32)29-14(2)20-4-5-21(31-30-20)24(25,26)27/h4-5,8-11,14-15H,3,6-7,12-13H2,1-2H3,(H,29,32)/t14-,15+/m1/s1 PGRAVNCJCWWOPT-CABCVRRESA-N 320129 3-(5-ethyl-1,3- thiazol-2-yl)-5- [(3S)- tetrahydrofuran-3- ylmethoxy]-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl}benzamide::US10174016, Example 296::US10202369, Example 296::US10472354, Example 296 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320129 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320129&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397487 384223403 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632588 C[C@@H](NC(=O)c1cc(OC[C@@H]2CCOC2)cc(c1)-c1ncc(s1)C1CCC1)c1ccc(nn1)C(F)(F)F InChI=1S/C26H27F3N4O3S/c1-15(21-5-6-23(33-32-21)26(27,28)29)31-24(34)18-9-19(25-30-12-22(37-25)17-3-2-4-17)11-20(10-18)36-14-16-7-8-35-13-16/h5-6,9-12,15-17H,2-4,7-8,13-14H2,1H3,(H,31,34)/t15-,16-/m1/s1 BURFLVDKSSJHQL-HZPDHXFCSA-N 320130 3-(5-cyclobutyl- 1,3-thiazol-2-yl)-5- [(3R)- tetrahydrofuran-3- ylmethoxy]-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl}benzamide::US10174016, Example 297::US10202369, Example 300::US10472354, Example 297 P2X purinoceptor 3 Homo sapiens 56.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320130 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320130&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397174 384223404 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632590 CC(C)c1cnc(s1)-c1cc(OC[C@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1ccc(nn1)C(F)(F)F InChI=1S/C25H27F3N4O3S/c1-14(2)21-11-29-24(36-21)18-8-17(9-19(10-18)35-13-16-6-7-34-12-16)23(33)30-15(3)20-4-5-22(32-31-20)25(26,27)28/h4-5,8-11,14-16H,6-7,12-13H2,1-3H3,(H,30,33)/t15-,16+/m1/s1 ZWFOSAQPAKMJAC-CVEARBPZSA-N 320131 3-[5-(propan-2-yl)- 1,3-thiazol-2-yl]-5- [(3S)- tetrahydrofuran-3- ylmethoxy]-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl}benzamide::US10174016, Example 298::US10202369, Example 299::US10472354, Example 298 P2X purinoceptor 3 Homo sapiens 62.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320131 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320131&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397407 384223405 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632592 CC(C)c1cnc(s1)-c1cc(OC[C@H]2CCCO2)cc(c1)C(=O)N[C@H](C)c1ccc(nn1)C(F)(F)F InChI=1S/C25H27F3N4O3S/c1-14(2)21-12-29-24(36-21)17-9-16(10-19(11-17)35-13-18-5-4-8-34-18)23(33)30-15(3)20-6-7-22(32-31-20)25(26,27)28/h6-7,9-12,14-15,18H,4-5,8,13H2,1-3H3,(H,30,33)/t15-,18-/m1/s1 QOJBRGRPZKZVKC-CRAIPNDOSA-N 320132 3-[5-(propan-2-yl)- 1,3-thiazol-2-yl]-5- [(2R)- tetrahydrofuran-2- ylmethoxy]-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl}benzamide::US10174016, Example 299::US10472354, Example 299 P2X purinoceptor 3 Homo sapiens 37.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320132 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320132&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397251 384223406 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632594 C[C@@H](NC(=O)c1cc(OC[C@@H]2CCCO2)cc(c1)-c1ncc(s1)C1CCC1)c1ccc(nn1)C(F)(F)F InChI=1S/C26H27F3N4O3S/c1-15(21-7-8-23(33-32-21)26(27,28)29)31-24(34)17-10-18(25-30-13-22(37-25)16-4-2-5-16)12-20(11-17)36-14-19-6-3-9-35-19/h7-8,10-13,15-16,19H,2-6,9,14H2,1H3,(H,31,34)/t15-,19+/m1/s1 BFQOMUOMPPUOAS-BEFAXECRSA-N 320133 3-(5-cyclobutyl- 1,3-thiazol-2-yl)-5- [(2S)- tetrahydrofuran-2- ylmethoxy]-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl}benzamide::US10174016, Example 300::US10472354, Example 300 P2X purinoceptor 3 Homo sapiens 78.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320133 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320133&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397755 384223407 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632596 CC(C)c1cnc(s1)-c1cc(OC[C@@H]2CCCO2)cc(c1)C(=O)N[C@H](C)c1ccc(nn1)C(F)(F)F InChI=1S/C25H27F3N4O3S/c1-14(2)21-12-29-24(36-21)17-9-16(10-19(11-17)35-13-18-5-4-8-34-18)23(33)30-15(3)20-6-7-22(32-31-20)25(26,27)28/h6-7,9-12,14-15,18H,4-5,8,13H2,1-3H3,(H,30,33)/t15-,18+/m1/s1 QOJBRGRPZKZVKC-QAPCUYQASA-N 320134 3-[5-(propan-2-yl)- 1,3-thiazol-2-yl]-5- [(2S)- tetrahydrofuran-2- ylmethoxy]-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl}benzamide::US10174016, Example 301::US10472354, Example 301 P2X purinoceptor 3 Homo sapiens 91.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320134 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320134&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397464 384223408 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632598 CCc1cnc(s1)-c1cc(OC[C@@H]2CCCO2)cc(c1)C(=O)N[C@H](C)c1ccc(nn1)C(F)(F)F InChI=1S/C24H25F3N4O3S/c1-3-19-12-28-23(35-19)16-9-15(10-18(11-16)34-13-17-5-4-8-33-17)22(32)29-14(2)20-6-7-21(31-30-20)24(25,26)27/h6-7,9-12,14,17H,3-5,8,13H2,1-2H3,(H,29,32)/t14-,17+/m1/s1 JBKILHBMFZDIIA-PBHICJAKSA-N 320135 3-(5-ethyl-1,3- thiazol-2-yl)-5- [(2S)- tetrahydrofuran-2- ylmethoxy]-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl}benzamide::US10174016, Example 302::US10202369, Example 302::US10472354, Example 302 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320135 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320135&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397753 384223409 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632600 C[C@@H](NC(=O)c1cc(OC2CCN(CC(F)(F)F)CC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C25H25F6N5O2S/c1-14-10-32-22(39-14)17-7-16(21(37)35-15(2)18-11-33-23(34-12-18)25(29,30)31)8-20(9-17)38-19-3-5-36(6-4-19)13-24(26,27)28/h7-12,15,19H,3-6,13H2,1-2H3,(H,35,37)/t15-/m1/s1 HEBACSHOFHMYBR-OAHLLOKOSA-N 320136 3-(5-methyl-1,3- thiazol-2-yl)-5-{[1- (2,2,2- trifluoroethyl) piperidin-4-yl]oxy}- N-{(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 303::US10202369, Example 310::US10472354, Example 303 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320136 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320136&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397490 384223410 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632602 C[C@@H](NC(=O)c1cc(OC2CCN(CC(F)F)CC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C25H26F5N5O2S/c1-14-10-31-23(38-14)17-7-16(8-20(9-17)37-19-3-5-35(6-4-19)13-21(26)27)22(36)34-15(2)18-11-32-24(33-12-18)25(28,29)30/h7-12,15,19,21H,3-6,13H2,1-2H3,(H,34,36)/t15-/m1/s1 LOLIYPRJHUXCPO-OAHLLOKOSA-N 320137 3-{[1-(2,2- difluoroethyl) piperidin-4-yl]oxy}- 5-(5-methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoroethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 304::US10202369, Example 308::US10472354, Example 304 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320137 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320137&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397386 384223411 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632604 C[C@@H](NC(=O)c1cc(OC2CCN(CC(F)F)CC2)cc(c1)-c1ncc(C)s1)c1ccc(C)nn1 InChI=1S/C25H29F2N5O2S/c1-15-4-5-22(31-30-15)17(3)29-24(33)18-10-19(25-28-13-16(2)35-25)12-21(11-18)34-20-6-8-32(9-7-20)14-23(26)27/h4-5,10-13,17,20,23H,6-9,14H2,1-3H3,(H,29,33)/t17-/m1/s1 BZVNHOBJGKGQCM-QGZVFWFLSA-N 320138 3-{[1-(2,2- difluoroethyl) piperidin-4-yl]oxy}-N- [(1R)-1-(6- methylpyridazin-3- yl)ethyl]-5-(5- methyl-1,3- thiazol-2-yl) benzamide::US10174016, Example 305::US10202369, Example 305::US10472354, Example 305 P2X purinoceptor 3 Homo sapiens 9.00 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320138 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320138&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397226 384223412 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632606 C[C@@H](NC(=O)c1cc(OC2CCN(CC(F)F)CC2)cc(c1)-c1ncc(C)s1)c1cnc(C)cn1 InChI=1S/C25H29F2N5O2S/c1-15-11-29-22(13-28-15)17(3)31-24(33)18-8-19(25-30-12-16(2)35-25)10-21(9-18)34-20-4-6-32(7-5-20)14-23(26)27/h8-13,17,20,23H,4-7,14H2,1-3H3,(H,31,33)/t17-/m1/s1 OVUBAZICSOPILB-QGZVFWFLSA-N 320139 3-{[1-(2,2- difluoroethyl) piperidin-4-yl]oxy}-N- [(1R)-1-(5- methylpyrazin-2- yl)ethyl]-5-(5- methyl-1,3- thiazol-2-yl) benzamide::US10174016, Example 306::US10202369, Example 306::US10472354, Example 306 P2X purinoceptor 3 Homo sapiens 42.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320139 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320139&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397132 384223413 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632608 Cc1cnc(s1)-c1cc(OC2CCN(CC(F)F)CC2)cc(c1)C(=O)NCc1ccc(C)nn1 InChI=1S/C24H27F2N5O2S/c1-15-3-4-19(30-29-15)13-27-23(32)17-9-18(24-28-12-16(2)34-24)11-21(10-17)33-20-5-7-31(8-6-20)14-22(25)26/h3-4,9-12,20,22H,5-8,13-14H2,1-2H3,(H,27,32) AGOFJROZQVOSRF-UHFFFAOYSA-N 320140 3-{[1-(2,2- difluoroethyl)piperidin- 4-yl]oxy}-N- [(6-methylpyridazin- 3-yl)methyl]-5-(5- methyl-1,3-thiazol-2- yl)benzamide::US10174016, Example 307::US10202369, Example 307::US10472354, Example 307 P2X purinoceptor 3 Homo sapiens 16.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320140 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320140&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397369 384223414 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632610 C[C@H](NC(=O)c1cc(OC2CCN(CC(F)F)CC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C25H26F5N5O2S/c1-14-10-31-23(38-14)17-7-16(8-20(9-17)37-19-3-5-35(6-4-19)13-21(26)27)22(36)34-15(2)18-11-32-24(33-12-18)25(28,29)30/h7-12,15,19,21H,3-6,13H2,1-2H3,(H,34,36)/t15-/m0/s1 LOLIYPRJHUXCPO-HNNXBMFYSA-N 320141 3-{[1-(2,2- difluoroethyl)piperidin- 4-yl]oxy}-5-(5- methyl-1,3-thiazol-2- yl)-N- {(1S)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 308::US10472354, Example 308 P2X purinoceptor 3 Homo sapiens 153 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320141 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320141&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397709 384223415 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632612 C[C@@H](NC(=O)c1cc(OC2CCN(CC(F)F)CC2)cc(c1)-c1ncc(C)s1)c1cnc(C)nc1 InChI=1S/C25H29F2N5O2S/c1-15-11-30-25(35-15)19-8-18(24(33)31-16(2)20-12-28-17(3)29-13-20)9-22(10-19)34-21-4-6-32(7-5-21)14-23(26)27/h8-13,16,21,23H,4-7,14H2,1-3H3,(H,31,33)/t16-/m1/s1 XIVLMPYTLPVWPV-MRXNPFEDSA-N 320142 3-{[1-(2,2- difluoroethyl)piperidin- 4-yl]oxy}-N- [(1R)-1-(2- methylpyrimidin- 5-yl)ethyl]-5-(5- methyl-1,3-thiazol-2- yl)benzamide::US10174016, Example 309::US10202369, Example 309::US10472354, Example 309 P2X purinoceptor 3 Homo sapiens 8.00 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320142 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320142&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397638 384223416 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632614 C[C@H](NC(=O)c1cc(OC2CCN(CC(F)(F)F)CC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C25H25F6N5O2S/c1-14-10-32-22(39-14)17-7-16(21(37)35-15(2)18-11-33-23(34-12-18)25(29,30)31)8-20(9-17)38-19-3-5-36(6-4-19)13-24(26,27)28/h7-12,15,19H,3-6,13H2,1-2H3,(H,35,37)/t15-/m0/s1 HEBACSHOFHMYBR-HNNXBMFYSA-N 320143 3-(5-methyl-1,3- thiazol-2-yl)-5-{[1- (2,2,2- trifluoroethyl) piperidin-4-yl]oxy}-N- {(1S)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 310::US10472354, Example 310 P2X purinoceptor 3 Homo sapiens 116 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320143 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320143&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397431 384223417 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632616 C[C@@H](NC(=O)c1cc(OC2CCN(CC(F)(F)F)CC2)cc(c1)-c1ncc(C)s1)c1ccc(C)nn1 InChI=1S/C25H28F3N5O2S/c1-15-4-5-22(32-31-15)17(3)30-23(34)18-10-19(24-29-13-16(2)36-24)12-21(11-18)35-20-6-8-33(9-7-20)14-25(26,27)28/h4-5,10-13,17,20H,6-9,14H2,1-3H3,(H,30,34)/t17-/m1/s1 PEAPNGOBIXQGEJ-QGZVFWFLSA-N 320144 N-[(1R)-1-(6- methylpyridazin-3- yl)ethyl]-3-(5- methyl-1,3- thiazol-2-yl)-5-{[1- (2,2,2- trifluoroethyl) piperidin-4-yl]oxy} benzamide::US10174016, Example 311::US10202369, Example 311::US10472354, Example 314 P2X purinoceptor 3 Homo sapiens 8.00 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320144 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320144&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397300 384223418 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632618 C[C@@H](NC(=O)c1cc(OC2CCN(CC(F)(F)F)CC2)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F InChI=1S/C25H25F6N5O2S/c1-14-12-32-23(39-14)17-9-16(22(37)33-15(2)20-3-4-21(35-34-20)25(29,30)31)10-19(11-17)38-18-5-7-36(8-6-18)13-24(26,27)28/h3-4,9-12,15,18H,5-8,13H2,1-2H3,(H,33,37)/t15-/m1/s1 AZRJUXHXOIFVSM-OAHLLOKOSA-N 320145 3-(5-methyl-1,3- thiazol-2-yl)-5-{[1- (2,2,2- trifluoroethyl) piperidin-4-yl]oxy}-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl}benzamide::US10174016, Example 312::US10202369, Example 312::US10472354, Example 312 P2X purinoceptor 3 Homo sapiens 9.00 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320145 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320145&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397364 384223419 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632620 C[C@@H](NC(=O)c1cc(OC2CCN(CC(F)(F)F)CC2)cc(c1)-c1ncc(C)s1)c1cnc(C)cn1 InChI=1S/C25H28F3N5O2S/c1-15-11-30-22(13-29-15)17(3)32-23(34)18-8-19(24-31-12-16(2)36-24)10-21(9-18)35-20-4-6-33(7-5-20)14-25(26,27)28/h8-13,17,20H,4-7,14H2,1-3H3,(H,32,34)/t17-/m1/s1 VOYLEHBGAUIAGN-QGZVFWFLSA-N 320146 N-[(1R)-1-(5- methylpyrazin-2- yl)ethyl]-3-(5- methyl-1,3- thiazol-2-yl)-5-{[1- (2,2,2- trifluoroethyl) piperidin-4- yl]oxy}benzamide::US10174016, Example 313::US10202369, Example 313::US10472354, Example 313 P2X purinoceptor 3 Homo sapiens 11.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320146 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320146&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397805 384223420 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632622 Cc1cnc(s1)-c1cc(OC2CCN(CC(F)(F)F)CC2)cc(c1)C(=O)NCc1ccc(C)nn1 InChI=1S/C24H26F3N5O2S/c1-15-3-4-19(31-30-15)13-28-22(33)17-9-18(23-29-12-16(2)35-23)11-21(10-17)34-20-5-7-32(8-6-20)14-24(25,26)27/h3-4,9-12,20H,5-8,13-14H2,1-2H3,(H,28,33) OUYWWDOEFAUISF-UHFFFAOYSA-N 320147 N-[(6- methylpyridazin-3- yl)methyl]-3-(5- methyl-1,3- thiazol-2-yl)-5-{[1- (2,2,2- trifluoroethyl) piperidin-4-yl]oxy} benzamide::US10174016, Example 314::US10202369, Example 314 P2X purinoceptor 3 Homo sapiens 8.00 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320147 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320147&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397402 384223421 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632624 C[C@@H](NC(=O)c1cc(OC2CCN(CC(F)(F)F)CC2)cc(c1)-c1ncc(C)s1)c1cnc(C)nc1 InChI=1S/C25H28F3N5O2S/c1-15-11-31-24(36-15)19-8-18(23(34)32-16(2)20-12-29-17(3)30-13-20)9-22(10-19)35-21-4-6-33(7-5-21)14-25(26,27)28/h8-13,16,21H,4-7,14H2,1-3H3,(H,32,34)/t16-/m1/s1 CJWKMIQNKLHRQL-MRXNPFEDSA-N 320148 N-[(1R)-1-(2- methylpyrimidin- 5-yl)ethyl]-3-(5- methyl-1,3- thiazol-2-yl)-5-{[1- (2,2,2- trifluoroethyl) piperidin-4-yl]oxy} benzamide::US10174016, Example 315::US10202369, Example 315::US10472354, Example 315 P2X purinoceptor 3 Homo sapiens 8.00 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320148 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320148&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397608 384223422 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632626 C[C@@H](NC(=O)c1cc(OC[C@H]2CCOC2)cc(c1)-c1ncc(Cl)s1)c1ccc(C)nn1 InChI=1S/C22H23ClN4O3S/c1-13-3-4-19(27-26-13)14(2)25-21(28)16-7-17(22-24-10-20(23)31-22)9-18(8-16)30-12-15-5-6-29-11-15/h3-4,7-10,14-15H,5-6,11-12H2,1-2H3,(H,25,28)/t14-,15+/m1/s1 OPFRVFRBCBSDJR-CABCVRRESA-N 320149 3-(5-chloro-1,3- thiazol-2-yl)-N- [(1R)-1-(6- methylpyridazin-3- yl)ethyl]-5-[(3S)- tetrahydrofuran-3- ylmethoxy]benzamide::US10174016, Example 316::US10472354, Example 316 P2X purinoceptor 3 Homo sapiens 21.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320149 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320149&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397598 384223423 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632628 C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(Cl)s1)c1ccc(C)nn1 InChI=1S/C21H21ClN4O3S/c1-12-3-4-18(26-25-12)13(2)24-20(27)14-7-15(21-23-10-19(22)30-21)9-17(8-14)29-16-5-6-28-11-16/h3-4,7-10,13,16H,5-6,11H2,1-2H3,(H,24,27)/t13-,16-/m1/s1 GKNCXHRLEQHNKW-CZUORRHYSA-N 320150 3-(5-chloro-1,3- thiazol-2-yl)-N- [(1R)-1-(6- methylpyridazin-3- yl)ethyl]-5-[(3R)- tetrahydrofuran-3- yloxy]benzamide::US10174016, Example 317::US10202369, Example 317::US10472354, Example 317 P2X purinoceptor 3 Homo sapiens 45.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320150 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320150&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397433 384223424 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632506 CC(C)c1cnc(s1)-c1cc(O[C@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1cnc(C)cn1 InChI=1S/C24H28N4O3S/c1-14(2)22-12-27-24(32-22)18-7-17(8-20(9-18)31-19-5-6-30-13-19)23(29)28-16(4)21-11-25-15(3)10-26-21/h7-12,14,16,19H,5-6,13H2,1-4H3,(H,28,29)/t16-,19+/m1/s1 ULUQVVVXKLITBV-APWZRJJASA-N 320089 N-[(1R)-1-(5- methylpyrazin-2- yl)ethyl]-3-[5- (propan-2-yl)-1,3- thiazol-2-yl]-5- [(3S)- tetrahydrofuran-3- yloxy]benzamide::US10174016, Example 256::US10202369, Example 256::US10472354, Example 256 P2X purinoceptor 3 Homo sapiens 136 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320089 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320089&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397239 384223363 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632508 CC(C)c1cnc(s1)-c1cc(O[C@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C24H25F3N4O3S/c1-13(2)20-11-28-22(35-20)16-6-15(7-19(8-16)34-18-4-5-33-12-18)21(32)31-14(3)17-9-29-23(30-10-17)24(25,26)27/h6-11,13-14,18H,4-5,12H2,1-3H3,(H,31,32)/t14-,18+/m1/s1 COCLYUAEQYUAPW-KDOFPFPSSA-N 320090 3-[5-(propan-2-yl)- 1,3-thiazol-2-yl]-5- [(3S)- tetrahydrofuran-3- yloxy]-N-{(1R)-1- [2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 257::US10202369, Example 257::US10472354, Example 257 P2X purinoceptor 3 Homo sapiens 47.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320090 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320090&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397534 384223364 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632510 CCc1cnc(s1)-c1cc(OC[C@@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1ccc(C)nn1 InChI=1S/C24H28N4O3S/c1-4-21-12-25-24(32-21)19-9-18(10-20(11-19)31-14-17-7-8-30-13-17)23(29)26-16(3)22-6-5-15(2)27-28-22/h5-6,9-12,16-17H,4,7-8,13-14H2,1-3H3,(H,26,29)/t16-,17-/m1/s1 CPQUPRVXRIYFHX-IAGOWNOFSA-N 320091 3-(5-ethyl-1,3- thiazol-2-yl)-N- [(1R)-1-(6- methylpyridazin-3- yl)ethyl]-5-[(3R)- tetrahydrofuran-3- ylmethoxy] benzamide::US10174016, Example 258::US10202369, Example 258::US10472354, Example 282 P2X purinoceptor 3 Homo sapiens 4.00 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320091 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320091&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397177 384223365 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632512 CCc1cnc(s1)-c1cc(OC[C@@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1cnc(C)cn1 InChI=1S/C24H28N4O3S/c1-4-21-11-27-24(32-21)19-7-18(8-20(9-19)31-14-17-5-6-30-13-17)23(29)28-16(3)22-12-25-15(2)10-26-22/h7-12,16-17H,4-6,13-14H2,1-3H3,(H,28,29)/t16-,17-/m1/s1 PZFOCXJBZDWRSU-IAGOWNOFSA-N 320092 3-(5-ethyl-1,3- thiazol-2-yl)-N- [(1R)-1-(5- methylpyrazin-2- yl)ethyl]-5-[(3R)- tetrahydrofuran-3- ylmethoxy] benzamide::US10174016, Example 259::US10202369, Example 259::US10472354, Example 283 P2X purinoceptor 3 Homo sapiens 10.00 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320092 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320092&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397564 384223366 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632514 CCc1cnc(s1)-c1cc(OC[C@@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C24H25F3N4O3S/c1-3-20-11-28-22(35-20)17-6-16(7-19(8-17)34-13-15-4-5-33-12-15)21(32)31-14(2)18-9-29-23(30-10-18)24(25,26)27/h6-11,14-15H,3-5,12-13H2,1-2H3,(H,31,32)/t14-,15-/m1/s1 VOKPPDDBRIDGES-HUUCEWRRSA-N 320093 3-(5-ethyl-1,3- thiazol-2-yl)-5- [(3R)- tetrahydrofuran-3- ylmethoxy]-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 260::US10202369, Example 260::US10472354, Example 260 P2X purinoceptor 3 Homo sapiens 2.00 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320093 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320093&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397266 384223367 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632516 C[C@@H](NC(=O)c1cc(OC[C@@H]2CCOC2)cc(c1)-c1ncc(s1)C1CCC1)c1ccc(C)nn1 InChI=1S/C26H30N4O3S/c1-16-6-7-23(30-29-16)17(2)28-25(31)20-10-21(26-27-13-24(34-26)19-4-3-5-19)12-22(11-20)33-15-18-8-9-32-14-18/h6-7,10-13,17-19H,3-5,8-9,14-15H2,1-2H3,(H,28,31)/t17-,18-/m1/s1 KRMAXJMLJAVOGJ-QZTJIDSGSA-N 320094 3-(5-cyclobutyl- 1,3-thiazol-2-yl)- N-[(1R)-1-(6- methylpyridazin-3- yl)ethyl]-5-[(3R)- tetrahydrofuran-3- ylmethoxy] benzamide::US10174016, Example 261::US10202369, Example 261::US10472354, Example 261 P2X purinoceptor 3 Homo sapiens 45.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320094 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320094&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397842 384223368 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632518 C[C@@H](NC(=O)c1cc(OC[C@@H]2CCOC2)cc(c1)-c1ncc(s1)C1CCC1)c1cnc(C)cn1 InChI=1S/C26H30N4O3S/c1-16-11-28-23(12-27-16)17(2)30-25(31)20-8-21(26-29-13-24(34-26)19-4-3-5-19)10-22(9-20)33-15-18-6-7-32-14-18/h8-13,17-19H,3-7,14-15H2,1-2H3,(H,30,31)/t17-,18-/m1/s1 ZBRXLMDGZXDHGV-QZTJIDSGSA-N 320095 3-(5-cyclobutyl- 1,3-thiazol-2-yl)- N-[(1R)-1-(5- methylpyrazin-2- yl)ethyl]-5-[(3R)- tetrahydrofuran-3- ylmethoxy] benzamide::US10174016, Example 262::US10202369, Example 262::US10472354, Example 262 P2X purinoceptor 3 Homo sapiens 85.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320095 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320095&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397383 384223369 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632520 C[C@@H](NC(=O)c1cc(OC[C@@H]2CCOC2)cc(c1)-c1ncc(s1)C1CCC1)c1cnc(nc1)C(F)(F)F InChI=1S/C26H27F3N4O3S/c1-15(20-10-31-25(32-11-20)26(27,28)29)33-23(34)18-7-19(24-30-12-22(37-24)17-3-2-4-17)9-21(8-18)36-14-16-5-6-35-13-16/h7-12,15-17H,2-6,13-14H2,1H3,(H,33,34)/t15-,16-/m1/s1 JWRPHAGJMIAQMD-HZPDHXFCSA-N 320096 3-(5-cyclobutyl- 1,3-thiazol-2-yl)-5- [(3R)- tetrahydrofuran-3- ylmethoxy]-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 263::US10202369, Example 263::US10472354, Example 263 P2X purinoceptor 3 Homo sapiens 33.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320096 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320096&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397122 384223370 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632522 CC(C)c1cnc(s1)-c1cc(OC[C@@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1ccc(C)nn1 InChI=1S/C25H30N4O3S/c1-15(2)23-12-26-25(33-23)20-9-19(10-21(11-20)32-14-18-7-8-31-13-18)24(30)27-17(4)22-6-5-16(3)28-29-22/h5-6,9-12,15,17-18H,7-8,13-14H2,1-4H3,(H,27,30)/t17-,18-/m1/s1 HVLSFPXITWENER-QZTJIDSGSA-N 320097 N-[(1R)-1-(6- methylpyridazin-3- yl)ethyl]-3-[5- (propan-2-yl)-1,3- thiazol-2-yl]-5- [(3R)- tetrahydrofuran-3- ylmethoxy] benzamide::US10174016, Example 264::US10202369, Example 264::US10472354, Example 264 P2X purinoceptor 3 Homo sapiens 81.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320097 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320097&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397620 384223371 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632524 CC(C)c1cnc(s1)-c1cc(OC[C@@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1cnc(C)cn1 InChI=1S/C25H30N4O3S/c1-15(2)23-12-28-25(33-23)20-7-19(8-21(9-20)32-14-18-5-6-31-13-18)24(30)29-17(4)22-11-26-16(3)10-27-22/h7-12,15,17-18H,5-6,13-14H2,1-4H3,(H,29,30)/t17-,18-/m1/s1 MWBSFWZECXCRJX-QZTJIDSGSA-N 320098 N-[(1R)-1-(5- methylpyrazin-2- yl)ethyl]-3-[5- (propan-2-yl)-1,3- thiazol-2-yl]-5- [(3R)- tetrahydrofuran-3- ylmethoxy] benzamide::US10174016, Example 265::US10202369, Example 265::US10472354, Example 265 P2X purinoceptor 3 Homo sapiens 104 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320098 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320098&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397233 384223372 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632526 CC(C)c1cnc(s1)-c1cc(OC[C@@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C25H27F3N4O3S/c1-14(2)21-11-29-23(36-21)18-6-17(7-20(8-18)35-13-16-4-5-34-12-16)22(33)32-15(3)19-9-30-24(31-10-19)25(26,27)28/h6-11,14-16H,4-5,12-13H2,1-3H3,(H,32,33)/t15-,16-/m1/s1 JZRSBKDBMGCFDH-HZPDHXFCSA-N 320099 3-[5-(propan-2-yl)- 1,3-thiazol-2-yl]-5- [(3R)- tetrahydrofuran-3- ylmethoxy]-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 266::US10202369, Example 266::US10472354, Example 266 P2X purinoceptor 3 Homo sapiens 41.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320099 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320099&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397337 384223373 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632528 CCc1cnc(s1)-c1cc(OC[C@H]2CCCO2)cc(c1)C(=O)N[C@H](C)c1ccc(C)nn1 InChI=1S/C24H28N4O3S/c1-4-21-13-25-24(32-21)18-10-17(11-20(12-18)31-14-19-6-5-9-30-19)23(29)26-16(3)22-8-7-15(2)27-28-22/h7-8,10-13,16,19H,4-6,9,14H2,1-3H3,(H,26,29)/t16-,19-/m1/s1 CEYURJDFNAEZIM-VQIMIIECSA-N 320100 3-(5-ethyl-1,3- thiazol-2-yl)-N- [(1R)-1-(6- methylpyridazin-3- yl)ethyl]-5-[(2R)- tetrahydrofuran-2- ylmethoxy] benzamide::US10174016, Example 267::US10202369, Example 276 P2X purinoceptor 3 Homo sapiens 14.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320100 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320100&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397219 384223374 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632530 CCc1cnc(s1)-c1cc(OC[C@H]2CCCO2)cc(c1)C(=O)N[C@H](C)c1cnc(C)cn1 InChI=1S/C24H28N4O3S/c1-4-21-12-27-24(32-21)18-8-17(9-20(10-18)31-14-19-6-5-7-30-19)23(29)28-16(3)22-13-25-15(2)11-26-22/h8-13,16,19H,4-7,14H2,1-3H3,(H,28,29)/t16-,19-/m1/s1 AKBLPSFNNBDTQK-VQIMIIECSA-N 320101 3-(5-ethyl-1,3- thiazol-2-yl)-N- [(1R)-1-(5- methylpyrazin-2- yl)ethyl]-5-[(2R)- tetrahydrofuran-2- ylmethoxy] benzamide::US10174016, Example 268::US10202369, Example 277 P2X purinoceptor 3 Homo sapiens 14.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320101 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320101&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397780 384223375 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632532 CCc1cnc(s1)-c1cc(OC[C@H]2CCCO2)cc(c1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C24H25F3N4O3S/c1-3-20-12-28-22(35-20)16-7-15(8-19(9-16)34-13-18-5-4-6-33-18)21(32)31-14(2)17-10-29-23(30-11-17)24(25,26)27/h7-12,14,18H,3-6,13H2,1-2H3,(H,31,32)/t14-,18-/m1/s1 IDFXYIYQWCENGA-RDTXWAMCSA-N 320102 3-(5-ethyl-1,3- thiazol-2-yl)-5- [(2R)- tetrahydrofuran-2- ylmethoxy]-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 269::US10202369, Example 278 P2X purinoceptor 3 Homo sapiens 2.00 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320102 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320102&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397217 384223376 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632534 C[C@@H](NC(=O)c1cc(OC[C@H]2CCCO2)cc(c1)-c1ncc(s1)C1CCC1)c1ccc(C)nn1 InChI=1S/C26H30N4O3S/c1-16-8-9-23(30-29-16)17(2)28-25(31)19-11-20(26-27-14-24(34-26)18-5-3-6-18)13-22(12-19)33-15-21-7-4-10-32-21/h8-9,11-14,17-18,21H,3-7,10,15H2,1-2H3,(H,28,31)/t17-,21-/m1/s1 NLLVDMMXBRFWGS-DYESRHJHSA-N 320103 3-(5-cyclobutyl- 1,3-thiazol-2-yl)- N-[(1R)-1-(6- methylpyridazin-3- yl)ethyl]-5-[(2R)- tetrahydrofuran-2- ylmethoxy] benzamide::US10174016, Example 270::US10202369, Example 270 P2X purinoceptor 3 Homo sapiens 25.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320103 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320103&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397499 384223377 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632536 C[C@@H](NC(=O)c1cc(OC[C@H]2CCCO2)cc(c1)-c1ncc(s1)C1CCC1)c1cnc(C)cn1 InChI=1S/C26H30N4O3S/c1-16-12-28-23(13-27-16)17(2)30-25(31)19-9-20(26-29-14-24(34-26)18-5-3-6-18)11-22(10-19)33-15-21-7-4-8-32-21/h9-14,17-18,21H,3-8,15H2,1-2H3,(H,30,31)/t17-,21-/m1/s1 BHRXSWOPMLFOCG-DYESRHJHSA-N 320104 3-(5-cyclobutyl- 1,3-thiazol-2-yl)- N-[(1R)-1-(5- methylpyrazin-2- yl)ethyl]-5-[(2R)- tetrahydrofuran-2- ylmethoxy] benzamide::US10174016, Example 271::US10202369, Example 271 P2X purinoceptor 3 Homo sapiens 45.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320104 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320104&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397691 384223378 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632538 C[C@@H](NC(=O)c1cc(OC[C@H]2CCCO2)cc(c1)-c1ncc(s1)C1CCC1)c1cnc(nc1)C(F)(F)F InChI=1S/C26H27F3N4O3S/c1-15(19-11-31-25(32-12-19)26(27,28)29)33-23(34)17-8-18(24-30-13-22(37-24)16-4-2-5-16)10-21(9-17)36-14-20-6-3-7-35-20/h8-13,15-16,20H,2-7,14H2,1H3,(H,33,34)/t15-,20-/m1/s1 ZERBIURYMMOJBU-FOIQADDNSA-N 320105 3-(5-cyclobutyl- 1,3-thiazol-2-yl)-5- [(2R)- tetrahydrofuran-2- ylmethoxy]-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 272::US10202369, Example 272 P2X purinoceptor 3 Homo sapiens 19.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320105 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320105&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397162 384223379 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632540 CC(C)c1cnc(s1)-c1cc(OC[C@H]2CCCO2)cc(c1)C(=O)N[C@H](C)c1ccc(C)nn1 InChI=1S/C25H30N4O3S/c1-15(2)23-13-26-25(33-23)19-10-18(11-21(12-19)32-14-20-6-5-9-31-20)24(30)27-17(4)22-8-7-16(3)28-29-22/h7-8,10-13,15,17,20H,5-6,9,14H2,1-4H3,(H,27,30)/t17-,20-/m1/s1 UAMKMSQRQBQFJK-YLJYHZDGSA-N 320106 N-[(1R)-1-(6- methylpyridazin-3- yl)ethyl]-3-[5- (propan-2-yl)-1,3- thiazol-2-yl]-5- [(2R)- tetrahydrofuran-2- ylmethoxy] benzamide::US10174016, Example 273::US10202369, Example 279 P2X purinoceptor 3 Homo sapiens 28.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320106 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320106&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397845 384223380 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632542 CC(C)c1cnc(s1)-c1cc(OC[C@H]2CCCO2)cc(c1)C(=O)N[C@H](C)c1cnc(C)cn1 InChI=1S/C25H30N4O3S/c1-15(2)23-13-28-25(33-23)19-8-18(9-21(10-19)32-14-20-6-5-7-31-20)24(30)29-17(4)22-12-26-16(3)11-27-22/h8-13,15,17,20H,5-7,14H2,1-4H3,(H,29,30)/t17-,20-/m1/s1 CNKRLRNKYMMPAE-YLJYHZDGSA-N 320107 N-[(1R)-1-(5- methylpyrazin-2- yl)ethyl]-3-[5- (propan-2-yl)-1,3- thiazol-2-yl]-5- [(2R)- tetrahydrofuran-2- ylmethoxy] benzamide::US10174016, Example 274::US10202369, Example 280 P2X purinoceptor 3 Homo sapiens 75.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320107 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320107&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397759 384223381 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632544 CC(C)c1cnc(s1)-c1cc(OC[C@H]2CCCO2)cc(c1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C25H27F3N4O3S/c1-14(2)21-12-29-23(36-21)17-7-16(8-20(9-17)35-13-19-5-4-6-34-19)22(33)32-15(3)18-10-30-24(31-11-18)25(26,27)28/h7-12,14-15,19H,4-6,13H2,1-3H3,(H,32,33)/t15-,19-/m1/s1 KTCCKJLURHRITN-DNVCBOLYSA-N 320108 3-[5-(propan-2-yl)- 1,3-thiazol-2-yl]-5- [(2R)- tetrahydrofuran-2- ylmethoxy]-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 275::US10202369, Example 281 P2X purinoceptor 3 Homo sapiens 21.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320108 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320108&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397795 384223382 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632546 CCc1cnc(s1)-c1cc(OC[C@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1ccc(C)nn1 InChI=1S/C24H28N4O3S/c1-4-21-12-25-24(32-21)19-9-18(10-20(11-19)31-14-17-7-8-30-13-17)23(29)26-16(3)22-6-5-15(2)27-28-22/h5-6,9-12,16-17H,4,7-8,13-14H2,1-3H3,(H,26,29)/t16-,17+/m1/s1 CPQUPRVXRIYFHX-SJORKVTESA-N 320109 3-(5-ethyl-1,3- thiazol-2-yl)-N- [(1R)-1-(6- methylpyridazin-3- yl)ethyl]-5-[(3S)- tetrahydrofuran-3- ylmethoxy] benzamide::US10174016, Example 276::US10472354, Example 276 P2X purinoceptor 3 Homo sapiens 10.00 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320109 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320109&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397609 384223383 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632548 CCc1cnc(s1)-c1cc(OC[C@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1cnc(C)cn1 InChI=1S/C24H28N4O3S/c1-4-21-11-27-24(32-21)19-7-18(8-20(9-19)31-14-17-5-6-30-13-17)23(29)28-16(3)22-12-25-15(2)10-26-22/h7-12,16-17H,4-6,13-14H2,1-3H3,(H,28,29)/t16-,17+/m1/s1 PZFOCXJBZDWRSU-SJORKVTESA-N 320110 3-(5-ethyl-1,3- thiazol-2-yl)-N- [(1R)-1-(5- methylpyrazin-2- yl)ethyl]-5-[(3S)- tetrahydrofuran-3- ylmethoxy] benzamide::US10174016, Example 277::US10472354, Example 277 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320110 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320110&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397468 384223384 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632550 CCc1cnc(s1)-c1cc(OC[C@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C24H25F3N4O3S/c1-3-20-11-28-22(35-20)17-6-16(7-19(8-17)34-13-15-4-5-33-12-15)21(32)31-14(2)18-9-29-23(30-10-18)24(25,26)27/h6-11,14-15H,3-5,12-13H2,1-2H3,(H,31,32)/t14-,15+/m1/s1 VOKPPDDBRIDGES-CABCVRRESA-N 320111 3-(5-ethyl-1,3- thiazol-2-yl)-5- [(3S)- tetrahydrofuran-3- ylmethoxy]-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 278::US10472354, Example 278 P2X purinoceptor 3 Homo sapiens 2.00 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320111 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320111&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397387 384223385 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632552 CC(C)c1cnc(s1)-c1cc(OC[C@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1ccc(C)nn1 InChI=1S/C25H30N4O3S/c1-15(2)23-12-26-25(33-23)20-9-19(10-21(11-20)32-14-18-7-8-31-13-18)24(30)27-17(4)22-6-5-16(3)28-29-22/h5-6,9-12,15,17-18H,7-8,13-14H2,1-4H3,(H,27,30)/t17-,18+/m1/s1 HVLSFPXITWENER-MSOLQXFVSA-N 320112 N-[(1R)-1-(6- methylpyridazin-3- yl)ethyl]-3-[5- (propan-2-yl)-1,3- thiazol-2-yl]-5- [(3S)- tetrahydrofuran-3- ylmethoxy] benzamide::US10174016, Example 279::US10472354, Example 279 P2X purinoceptor 3 Homo sapiens 115 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320112 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320112&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397672 384223386 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632554 CC(C)c1cnc(s1)-c1cc(OC[C@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1cnc(C)cn1 InChI=1S/C25H30N4O3S/c1-15(2)23-12-28-25(33-23)20-7-19(8-21(9-20)32-14-18-5-6-31-13-18)24(30)29-17(4)22-11-26-16(3)10-27-22/h7-12,15,17-18H,5-6,13-14H2,1-4H3,(H,29,30)/t17-,18+/m1/s1 MWBSFWZECXCRJX-MSOLQXFVSA-N 320113 N-[(1R)-1-(5- methylpyrazin-2- yl)ethyl]-3-[5- (propan-2-yl)-1,3- thiazol-2-yl]-5- [(3S)- tetrahydrofuran-3- ylmethoxy] benzamide::US10174016, Example 280::US10472354, Example 280 P2X purinoceptor 3 Homo sapiens 51.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320113 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320113&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397160 384223387 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632556 CC(C)c1cnc(s1)-c1cc(OC[C@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C25H27F3N4O3S/c1-14(2)21-11-29-23(36-21)18-6-17(7-20(8-18)35-13-16-4-5-34-12-16)22(33)32-15(3)19-9-30-24(31-10-19)25(26,27)28/h6-11,14-16H,4-5,12-13H2,1-3H3,(H,32,33)/t15-,16+/m1/s1 JZRSBKDBMGCFDH-CVEARBPZSA-N 320114 3-[5-(propan-2-yl)- 1,3-thiazol-2-yl]-5- [(3S)- tetrahydrofuran-3- ylmethoxy]-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 281::US10472354, Example 281 P2X purinoceptor 3 Homo sapiens 26.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320114 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320114&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397335 384223388 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632558 CCc1cnc(s1)-c1cc(OC[C@@H]2CCCO2)cc(c1)C(=O)N[C@H](C)c1ccc(C)nn1 InChI=1S/C24H28N4O3S/c1-4-21-13-25-24(32-21)18-10-17(11-20(12-18)31-14-19-6-5-9-30-19)23(29)26-16(3)22-8-7-15(2)27-28-22/h7-8,10-13,16,19H,4-6,9,14H2,1-3H3,(H,26,29)/t16-,19+/m1/s1 CEYURJDFNAEZIM-APWZRJJASA-N 320115 3-(5-ethyl-1,3- thiazol-2-yl)-N- [(1R)-1-(6- methylpyridazin-3- yl)ethyl]-5-[(2S)- tetrahydrofuran-2- ylmethoxy] benzamide::US10174016, Example 282::US10202369, Example 282 P2X purinoceptor 3 Homo sapiens 8.00 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320115 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320115&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397632 384223389 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632560 CCc1cnc(s1)-c1cc(OC[C@@H]2CCCO2)cc(c1)C(=O)N[C@H](C)c1cnc(C)cn1 InChI=1S/C24H28N4O3S/c1-4-21-12-27-24(32-21)18-8-17(9-20(10-18)31-14-19-6-5-7-30-19)23(29)28-16(3)22-13-25-15(2)11-26-22/h8-13,16,19H,4-7,14H2,1-3H3,(H,28,29)/t16-,19+/m1/s1 AKBLPSFNNBDTQK-APWZRJJASA-N 320116 3-(5-ethyl-1,3- thiazol-2-yl)-N- [(1R)-1-(5- methylpyrazin-2- yl)ethyl]-5-[(2S)- tetrahydrofuran-2- ylmethoxy] benzamide::US10174016, Example 283::US10202369, Example 283 P2X purinoceptor 3 Homo sapiens 10.00 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320116 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320116&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397578 384223390 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632562 CCc1cnc(s1)-c1cc(OC[C@@H]2CCCO2)cc(c1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C24H25F3N4O3S/c1-3-20-12-28-22(35-20)16-7-15(8-19(9-16)34-13-18-5-4-6-33-18)21(32)31-14(2)17-10-29-23(30-11-17)24(25,26)27/h7-12,14,18H,3-6,13H2,1-2H3,(H,31,32)/t14-,18+/m1/s1 IDFXYIYQWCENGA-KDOFPFPSSA-N 320117 3-(5-ethyl-1,3- thiazol-2-yl)-5- [(2S)- tetrahydrofuran-2- ylmethoxy]-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 284::US10202369, Example 284::US10472354, Example 284 P2X purinoceptor 3 Homo sapiens 4.00 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320117 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320117&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397623 384223391 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632564 C[C@@H](NC(=O)c1cc(OC[C@@H]2CCCO2)cc(c1)-c1ncc(s1)C1CCC1)c1ccc(C)nn1 InChI=1S/C26H30N4O3S/c1-16-8-9-23(30-29-16)17(2)28-25(31)19-11-20(26-27-14-24(34-26)18-5-3-6-18)13-22(12-19)33-15-21-7-4-10-32-21/h8-9,11-14,17-18,21H,3-7,10,15H2,1-2H3,(H,28,31)/t17-,21+/m1/s1 NLLVDMMXBRFWGS-UTKZUKDTSA-N 320118 3-(5-cyclobutyl- 1,3-thiazol-2-yl)- N-[(1R)-1-(6- methylpyridazin-3- yl)ethyl]-5-[(2S)- tetrahydrofuran-2- ylmethoxy] benzamide::US10174016, Example 285::US10202369, Example 285::US10472354, Example 285 P2X purinoceptor 3 Homo sapiens 113 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320118 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320118&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397163 384223392 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632566 C[C@@H](NC(=O)c1cc(OC[C@@H]2CCCO2)cc(c1)-c1ncc(s1)C1CCC1)c1cnc(C)cn1 InChI=1S/C26H30N4O3S/c1-16-12-28-23(13-27-16)17(2)30-25(31)19-9-20(26-29-14-24(34-26)18-5-3-6-18)11-22(10-19)33-15-21-7-4-8-32-21/h9-14,17-18,21H,3-8,15H2,1-2H3,(H,30,31)/t17-,21+/m1/s1 BHRXSWOPMLFOCG-UTKZUKDTSA-N 320119 3-(5-cyclobutyl- 1,3-thiazol-2-yl)- N-[(1R)-1-(5- methylpyrazin-2- yl)ethyl]-5-[(2S)- tetrahydrofuran-2- ylmethoxy]benzamide::US10174016, Example 286::US10202369, Example 286::US10472354, Example 286 P2X purinoceptor 3 Homo sapiens 87.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320119 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320119&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397754 384223393 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632630 C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(Cl)s1)c1ccc(nn1)C(F)(F)F InChI=1S/C21H18ClF3N4O3S/c1-11(16-2-3-17(29-28-16)21(23,24)25)27-19(30)12-6-13(20-26-9-18(22)33-20)8-15(7-12)32-14-4-5-31-10-14/h2-3,6-9,11,14H,4-5,10H2,1H3,(H,27,30)/t11-,14-/m1/s1 WZQSUVWYIQCPQJ-BXUZGUMPSA-N 320151 3-(5-chloro-1,3- thiazol-2-yl)-5- [(3R)- tetrahydrofuran-3- yloxy]-N-{(1R)-1- [6- (trifluoromethyl) pyridazin-3- yl]ethyl}benzamide::US10174016, Example 318::US10202369, Example 318::US10472354, Example 318 P2X purinoceptor 3 Homo sapiens 32.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320151 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320151&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397509 384223425 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632632 C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(Cl)s1)c1cnc(C)cn1 InChI=1S/C21H21ClN4O3S/c1-12-8-24-18(9-23-12)13(2)26-20(27)14-5-15(21-25-10-19(22)30-21)7-17(6-14)29-16-3-4-28-11-16/h5-10,13,16H,3-4,11H2,1-2H3,(H,26,27)/t13-,16-/m1/s1 NPEHDEPJRQIOFY-CZUORRHYSA-N 320152 3-(5-chloro-1,3- thiazol-2-yl)-N- [(1R)-1-(5- methylpyrazin-2- yl)ethyl]-5-[(3R)- tetrahydrofuran-3- yloxy]benzamide::US10174016, Example 319::US10202369, Example 319::US10472354, Example 319 P2X purinoceptor 3 Homo sapiens 76.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320152 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320152&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397412 384223426 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632634 C[C@@H](NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(Cl)s1)c1ccc(nn1)C(F)(F)F InChI=1S/C21H18ClF3N4O3S/c1-11(16-2-3-17(29-28-16)21(23,24)25)27-19(30)12-6-13(20-26-9-18(22)33-20)8-15(7-12)32-14-4-5-31-10-14/h2-3,6-9,11,14H,4-5,10H2,1H3,(H,27,30)/t11-,14+/m1/s1 WZQSUVWYIQCPQJ-RISCZKNCSA-N 320153 3-(5-chloro-1,3- thiazol-2-yl)-5- [(3S)- tetrahydrofuran-3- yloxy]-N-{(1R)-1- [6- (trifluoromethyl) pyridazin-3- yl]ethyl}benzamide::US10174016, Example 320::US10202369, Example 320::US10472354, Example 320 P2X purinoceptor 3 Homo sapiens 33.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320153 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320153&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397157 384223427 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632636 C[C@@H](NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(Cl)s1)c1cnc(C)cn1 InChI=1S/C21H21ClN4O3S/c1-12-8-24-18(9-23-12)13(2)26-20(27)14-5-15(21-25-10-19(22)30-21)7-17(6-14)29-16-3-4-28-11-16/h5-10,13,16H,3-4,11H2,1-2H3,(H,26,27)/t13-,16+/m1/s1 NPEHDEPJRQIOFY-CJNGLKHVSA-N 320154 3-(5-chloro-1,3- thiazol-2-yl)-N- [(1R)-1-(5- methylpyrazin-2- yl)ethyl]-5-[(3S)- tetrahydrofuran-3- yloxy]benzamide::US10174016, Example 321::US10202369, Example 321::US10472354, Example 321 P2X purinoceptor 3 Homo sapiens 120 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320154 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320154&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397403 384223428 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632638 C[C@@H](NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(Cl)s1)c1ccc(C)nn1 InChI=1S/C21H21ClN4O3S/c1-12-3-4-18(26-25-12)13(2)24-20(27)14-7-15(21-23-10-19(22)30-21)9-17(8-14)29-16-5-6-28-11-16/h3-4,7-10,13,16H,5-6,11H2,1-2H3,(H,24,27)/t13-,16+/m1/s1 GKNCXHRLEQHNKW-CJNGLKHVSA-N 320155 3-(5-chloro-1,3- thiazol-2-yl)-N- [(1R)-1-(6- methylpyridazin-3- yl)ethyl]-5-[(3S)- tetrahydrofuran-3- yloxy]benzamide::US10174016, Example 322::US10202369, Example 322::US10472354, Example 322 P2X purinoceptor 3 Homo sapiens 49.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320155 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320155&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397765 384223429 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632640 C[C@@H](NC(=O)c1cc(OC[C@H]2CCOC2)cc(c1)-c1ncc(Cl)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C22H20ClF3N4O3S/c1-12(16-7-28-21(29-8-16)22(24,25)26)30-19(31)14-4-15(20-27-9-18(23)34-20)6-17(5-14)33-11-13-2-3-32-10-13/h4-9,12-13H,2-3,10-11H2,1H3,(H,30,31)/t12-,13+/m1/s1 SQNSHDCXZQFUAQ-OLZOCXBDSA-N 320156 3-(5-chloro-1,3- thiazol-2-yl)-5- [(3S)- tetrahydrofuran-3- ylmethoxy]-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 323::US10202369, Example 323::US10472354, Example 323 P2X purinoceptor 3 Homo sapiens 25.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320156 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320156&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397761 384223430 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632642 C[C@@H](NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(Cl)s1)c1ccc(C)nn1 InChI=1S/C22H23ClN4O3S/c1-13-3-4-19(27-26-13)14(2)25-21(28)15-9-16(22-24-12-20(23)31-22)11-18(10-15)30-17-5-7-29-8-6-17/h3-4,9-12,14,17H,5-8H2,1-2H3,(H,25,28)/t14-/m1/s1 WDEIMZWFSWTCLU-CQSZACIVSA-N 320158 3-(5-chloro-1,3- thiazol-2-yl)-N- [(1R)-1-(6- methylpyridazin-3- yl)ethyl]-5- (tetrahydro-2H- pyran-4- yloxy)benzamide::US10174016, Example 325::US10202369, Example 325::US10472354, Example 325 P2X purinoceptor 3 Homo sapiens 46.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320158 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320158&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397325 384223432 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632644 C[C@@H](NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(Cl)s1)c1ccc(C)nn1 InChI=1S/C22H23ClN4O3S/c1-13-3-4-19(27-26-13)14(2)25-21(28)15-9-16(22-24-12-20(23)31-22)11-18(10-15)30-17-5-7-29-8-6-17/h3-4,9-12,14,17H,5-8H2,1-2H3,(H,25,28)/t14-/m1/s1 WDEIMZWFSWTCLU-CQSZACIVSA-N 320158 3-(5-chloro-1,3- thiazol-2-yl)-N- [(1R)-1-(6- methylpyridazin-3- yl)ethyl]-5- (tetrahydro-2H- pyran-4- yloxy)benzamide::US10174016, Example 325::US10202369, Example 325::US10472354, Example 325 P2X purinoceptor 3 Homo sapiens 26.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320158 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320158&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397325 384223432 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632646 C[C@@H](NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(Cl)s1)c1ccc(nn1)C(F)(F)F InChI=1S/C22H20ClF3N4O3S/c1-12(17-2-3-18(30-29-17)22(24,25)26)28-20(31)13-8-14(21-27-11-19(23)34-21)10-16(9-13)33-15-4-6-32-7-5-15/h2-3,8-12,15H,4-7H2,1H3,(H,28,31)/t12-/m1/s1 LBZPSHGDCXIMLR-GFCCVEGCSA-N 320159 3-(5-chloro-1,3- thiazol-2-yl)-5- (tetrahydro-2H- pyran-4-yloxy)-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl}benzamide::US10174016, Example 326::US10202369, Example 326::US10472354, Example 326 P2X purinoceptor 3 Homo sapiens 21.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320159 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320159&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397539 384223433 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632648 C[C@@H](NC(=O)c1cc(OCC2(C)COC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H23F3N4O3S/c1-13-7-27-20(34-13)16-4-15(5-18(6-16)33-12-22(3)10-32-11-22)19(31)30-14(2)17-8-28-21(29-9-17)23(24,25)26/h4-9,14H,10-12H2,1-3H3,(H,30,31)/t14-/m1/s1 JVDZTZBJXQINIP-CQSZACIVSA-N 320160 3-[(3- methyloxetan-3- yl)methoxy]-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 327::US10202369, Example 327::US10472354, Example 327 P2X purinoceptor 3 Homo sapiens 10.00 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320160 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320160&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397492 384223434 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632650 C[C@@H](NC(=O)c1cc(OCC(C)(C)C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H25F3N4O2S/c1-13-9-27-20(33-13)16-6-15(7-18(8-16)32-12-22(3,4)5)19(31)30-14(2)17-10-28-21(29-11-17)23(24,25)26/h6-11,14H,12H2,1-5H3,(H,30,31)/t14-/m1/s1 CYTLZVKLWUDWCI-CQSZACIVSA-N 322517 3-(2-hydroxy-2- methylpropoxy)-5- (5-methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5-yl] ethyl}benzamide::US10183937, Example 328::US10202369, Example 328 P2X purinoceptor 3 Homo sapiens 12.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322517 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322517&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134338448 384225579 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632652 C[C@@H](NC(=O)c1cc(OCC2(C)CCCO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H25F3N4O3S/c1-14-10-28-21(35-14)17-7-16(8-19(9-17)33-13-23(3)5-4-6-34-23)20(32)31-15(2)18-11-29-22(30-12-18)24(25,26)27/h7-12,15H,4-6,13H2,1-3H3,(H,31,32)/t15-,23?/m1/s1 LFYNTNZWPQXJEM-NKTHEXPSSA-N 320162 3-[(2-methyltetrahydrofuran-2-yl)methoxy]-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide, as a mixture of two diastereoisomers::US10174016, Example 329::US10202369, Example 330::US10472354, Example 332 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320162 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320162&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397698 384223436 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632654 C[C@@H](NC(=O)c1cc(OCC2(C)CCCO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H25F3N4O3S/c1-14-10-28-21(35-14)17-7-16(8-19(9-17)33-13-23(3)5-4-6-34-23)20(32)31-15(2)18-11-29-22(30-12-18)24(25,26)27/h7-12,15H,4-6,13H2,1-3H3,(H,31,32)/t15-,23?/m1/s1 LFYNTNZWPQXJEM-NKTHEXPSSA-N 320162 3-[(2-methyltetrahydrofuran-2-yl)methoxy]-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide, as a mixture of two diastereoisomers::US10174016, Example 329::US10202369, Example 330::US10472354, Example 332 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320162 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320162&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397698 384223436 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632656 C[C@H](NC(=O)c1cc(OCC2(C)CCCO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H25F3N4O3S/c1-14-10-28-21(35-14)17-7-16(8-19(9-17)33-13-23(3)5-4-6-34-23)20(32)31-15(2)18-11-29-22(30-12-18)24(25,26)27/h7-12,15H,4-6,13H2,1-3H3,(H,31,32)/t15-,23?/m0/s1 LFYNTNZWPQXJEM-NGMICRHFSA-N 322520 US10183937, Example 331::US10202369, Example 331 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322520 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322520&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 138375412 384225582 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632658 C[C@@H](NC(=O)c1cc(OCC2(C)CCOC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H25F3N4O3S/c1-14-9-28-21(35-14)17-6-16(7-19(8-17)34-13-23(3)4-5-33-12-23)20(32)31-15(2)18-10-29-22(30-11-18)24(25,26)27/h6-11,15H,4-5,12-13H2,1-3H3,(H,31,32)/t15-,23?/m1/s1 FUZHKJYNGBDBHI-NKTHEXPSSA-N 320165 3-[(3-methyltetrahydrofuran-3-yl)methoxy]-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide, as a Mixture of Two Diastereoisomers::US10174016, Example 332::US10202369, Example 333 P2X purinoceptor 3 Homo sapiens 4.00 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320165 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320165&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397763 384223439 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632660 C[C@@H](NC(=O)c1cc(OCC2(C)CCOC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H25F3N4O3S/c1-14-9-28-21(35-14)17-6-16(7-19(8-17)34-13-23(3)4-5-33-12-23)20(32)31-15(2)18-10-29-22(30-11-18)24(25,26)27/h6-11,15H,4-5,12-13H2,1-3H3,(H,31,32)/t15-,23?/m1/s1 FUZHKJYNGBDBHI-NKTHEXPSSA-N 320165 3-[(3-methyltetrahydrofuran-3-yl)methoxy]-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide, as a Mixture of Two Diastereoisomers::US10174016, Example 332::US10202369, Example 333 P2X purinoceptor 3 Homo sapiens 4.00 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320165 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320165&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397763 384223439 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632662 C[C@H](NC(=O)c1cc(OCC2(C)CCOC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H25F3N4O3S/c1-14-9-28-21(35-14)17-6-16(7-19(8-17)34-13-23(3)4-5-33-12-23)20(32)31-15(2)18-10-29-22(30-11-18)24(25,26)27/h6-11,15H,4-5,12-13H2,1-3H3,(H,31,32)/t15-,23?/m0/s1 FUZHKJYNGBDBHI-NGMICRHFSA-N 322523 US10183937, Example 334::US10202369, Example 334 P2X purinoceptor 3 Homo sapiens 4.00 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322523 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322523&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 138375413 384225584 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632664 C[C@@H](NC(=O)c1cc(OC2CCC(=O)N(C)C2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H24F3N5O3S/c1-13-9-28-22(36-13)16-6-15(7-19(8-16)35-18-4-5-20(33)32(3)12-18)21(34)31-14(2)17-10-29-23(30-11-17)24(25,26)27/h6-11,14,18H,4-5,12H2,1-3H3,(H,31,34)/t14-,18?/m1/s1 CGMVCPWOPCCFBE-IKJXHCRLSA-N 320168 3-[(1-methyl-6-oxopiperidin-3-yl)oxy]-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide, as a mixture of two diastereoisomers::US10174016, Example 335::US10202369, Example 336::US10472354, Example 335 P2X purinoceptor 3 Homo sapiens 13.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320168 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320168&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397147 384223442 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632666 C[C@@H](NC(=O)c1cc(OC2CCC(=O)N(C)C2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H24F3N5O3S/c1-13-9-28-22(36-13)16-6-15(7-19(8-16)35-18-4-5-20(33)32(3)12-18)21(34)31-14(2)17-10-29-23(30-11-17)24(25,26)27/h6-11,14,18H,4-5,12H2,1-3H3,(H,31,34)/t14-,18?/m1/s1 CGMVCPWOPCCFBE-IKJXHCRLSA-N 320168 3-[(1-methyl-6-oxopiperidin-3-yl)oxy]-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide, as a mixture of two diastereoisomers::US10174016, Example 335::US10202369, Example 336::US10472354, Example 335 P2X purinoceptor 3 Homo sapiens 14.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320168 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320168&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397147 384223442 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632668 C[C@H](NC(=O)c1cc(OC2CCC(=O)N(C)C2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H24F3N5O3S/c1-13-9-28-22(36-13)16-6-15(7-19(8-16)35-18-4-5-20(33)32(3)12-18)21(34)31-14(2)17-10-29-23(30-11-17)24(25,26)27/h6-11,14,18H,4-5,12H2,1-3H3,(H,31,34)/t14-,18?/m0/s1 CGMVCPWOPCCFBE-PIVQAISJSA-N 322526 US10183937, Example 337::US10202369, Example 337 P2X purinoceptor 3 Homo sapiens 13.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322526 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322526&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 138375414 384225586 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632670 CC(O)C(C)Oc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C22H23F3N4O3S/c1-11-8-26-20(33-11)16-5-15(6-18(7-16)32-14(4)13(3)30)19(31)29-12(2)17-9-27-21(28-10-17)22(23,24)25/h5-10,12-14,30H,1-4H3,(H,29,31)/t12-,13?,14?/m1/s1 FSGDRFBLPAILDE-IYXRBSQSSA-N 319995 3-{[3-hydroxybutan-2-yl]oxy}-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 162::US10174016, Example 338::US10202369, Example 339::US10472354, Example 338 P2X purinoceptor 3 Homo sapiens 4.00 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319995 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319995&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397269 384223275 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632672 CC(O)C(C)Oc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C22H23F3N4O3S/c1-11-8-26-20(33-11)16-5-15(6-18(7-16)32-14(4)13(3)30)19(31)29-12(2)17-9-27-21(28-10-17)22(23,24)25/h5-10,12-14,30H,1-4H3,(H,29,31)/t12-,13?,14?/m1/s1 FSGDRFBLPAILDE-IYXRBSQSSA-N 319995 3-{[3-hydroxybutan-2-yl]oxy}-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 162::US10174016, Example 338::US10202369, Example 339::US10472354, Example 338 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319995 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319995&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397269 384223275 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632674 CC(O)C(C)Oc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C22H23F3N4O3S/c1-11-8-26-20(33-11)16-5-15(6-18(7-16)32-14(4)13(3)30)19(31)29-12(2)17-9-27-21(28-10-17)22(23,24)25/h5-10,12-14,30H,1-4H3,(H,29,31)/t12-,13?,14?/m0/s1 FSGDRFBLPAILDE-HSBZDZAISA-N 319996 US10174016, Example 163::US10202369, Example 340::US10472354, Example 162 P2X purinoceptor 3 Homo sapiens 3.00 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319996 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319996&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134328174 384223276 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632676 C[C@@H](NC(=O)c1cc(OC2C3COCC2CN(C)C3)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C26H28F3N5O3S/c1-14-7-30-24(38-14)17-4-16(23(35)33-15(2)18-8-31-25(32-9-18)26(27,28)29)5-21(6-17)37-22-19-10-34(3)11-20(22)13-36-12-19/h4-9,15,19-20,22H,10-13H2,1-3H3,(H,33,35)/t15-,19?,20?,22?/m1/s1 UOQSAFNLRPUQCS-DSXPMEPHSA-N 320174 3-[(7-methyl-3-oxa-7-azabicyclo[3.3.1]non-9-yl)oxy]-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide, as a Mixture of Two Stereoisomers::US10174016, Example 341::US10202369, Example 342::US10472354, Example 343 P2X purinoceptor 3 Homo sapiens 41.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320174 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320174&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397140 384223447 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632678 C[C@@H](NC(=O)c1cc(OC2C3COCC2CN(C)C3)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C26H28F3N5O3S/c1-14-7-30-24(38-14)17-4-16(23(35)33-15(2)18-8-31-25(32-9-18)26(27,28)29)5-21(6-17)37-22-19-10-34(3)11-20(22)13-36-12-19/h4-9,15,19-20,22H,10-13H2,1-3H3,(H,33,35)/t15-,19?,20?,22?/m1/s1 UOQSAFNLRPUQCS-DSXPMEPHSA-N 320174 3-[(7-methyl-3-oxa-7-azabicyclo[3.3.1]non-9-yl)oxy]-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide, as a Mixture of Two Stereoisomers::US10174016, Example 341::US10202369, Example 342::US10472354, Example 343 P2X purinoceptor 3 Homo sapiens 40.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320174 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320174&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397140 384223447 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632680 C[C@H](NC(=O)c1cc(OC2C3COCC2CN(C)C3)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C26H28F3N5O3S/c1-14-7-30-24(38-14)17-4-16(23(35)33-15(2)18-8-31-25(32-9-18)26(27,28)29)5-21(6-17)37-22-19-10-34(3)11-20(22)13-36-12-19/h4-9,15,19-20,22H,10-13H2,1-3H3,(H,33,35)/t15-,19?,20?,22?/m0/s1 UOQSAFNLRPUQCS-LONTXVJRSA-N 320176 US10174016, Example 343::US10202369, Example 343 P2X purinoceptor 3 Homo sapiens 135 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320176 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320176&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 138374917 384223449 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632682 CC(C)N1CC2COCC(C1)C2Oc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C28H32F3N5O3S/c1-15(2)36-11-21-13-38-14-22(12-36)24(21)39-23-6-18(5-19(7-23)26-32-8-16(3)40-26)25(37)35-17(4)20-9-33-27(34-10-20)28(29,30)31/h5-10,15,17,21-22,24H,11-14H2,1-4H3,(H,35,37)/t17-,21?,22?,24?/m1/s1 IQKMSJWJAJKSIQ-CBDSMJNHSA-N 320177 3-[(7-isopropyl-3-oxa-7-azabicyclo[3.3.1]non-9-yl)oxy]-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide, as a mixture of two stereoisomers::US10174016, Example 344::US10202369, Example 344::US10472354, Example 344 P2X purinoceptor 3 Homo sapiens 34.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320177 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320177&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397285 384223450 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632684 COC(=O)N1CC2COCC(C1)C2Oc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C27H28F3N5O5S/c1-14-7-31-24(41-14)17-4-16(23(36)34-15(2)18-8-32-25(33-9-18)27(28,29)30)5-21(6-17)40-22-19-10-35(26(37)38-3)11-20(22)13-39-12-19/h4-9,15,19-20,22H,10-13H2,1-3H3,(H,34,36)/t15-,19?,20?,22?/m1/s1 GHSFQGHMPBJNHK-DSXPMEPHSA-N 320178 US10174016, Example 345::US10202369, Example 345::methyl 9-[3-(5-methyl-1,3-thiazol-2-yl)-5-({(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}carbamoyl)phenoxy]-3-oxa-7-azabicycle[3.3.1]nonane-7-carboxylate, as a mixture of two stereoisomers P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320178 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320178&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397363 384223451 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632686 C[C@@H](NC(=O)c1cc(OC[C@H]2CN(CCO2)C(=O)OC(C)(C)C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C28H32F3N5O5S/c1-16-11-32-24(42-16)19-8-18(23(37)35-17(2)20-12-33-25(34-13-20)28(29,30)31)9-21(10-19)40-15-22-14-36(6-7-39-22)26(38)41-27(3,4)5/h8-13,17,22H,6-7,14-15H2,1-5H3,(H,35,37)/t17-,22-/m1/s1 OEKUZTDVCYAZBS-VGOFRKELSA-N 320179 Tert-butyl (2R)-2-{[3-(5-methyl-1,3-thiazol-2-yl)-5-({(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}carbamoyl)phenoxy]methyl}morpholine-4-carboxylate::US10174016, Example 346::US10202369, Example 346::US10472354, Example 346 P2X purinoceptor 3 Homo sapiens 13.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320179 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320179&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134338449 384223452 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632688 C[C@@H](NC(=O)c1cc(OC[C@H]2CNCCO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H24F3N5O3S/c1-13-8-28-21(35-13)16-5-15(6-18(7-16)34-12-19-11-27-3-4-33-19)20(32)31-14(2)17-9-29-22(30-10-17)23(24,25)26/h5-10,14,19,27H,3-4,11-12H2,1-2H3,(H,31,32)/t14-,19-/m1/s1 HRVUBTPQOQIHTK-AUUYWEPGSA-N 320180 3-(5-Methyl-1,3-thiazol-2-yl)-5-[(2R)-morpholin-2-ylmethoxy]-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 347::US10202369, Example 347::US10472354, Example 347 P2X purinoceptor 3 Homo sapiens 9.00 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320180 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320180&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397601 384223453 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632690 C[C@@H](NC(=O)c1cc(OC[C@H]2CN(C)CCO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H26F3N5O3S/c1-14-9-28-22(36-14)17-6-16(7-19(8-17)35-13-20-12-32(3)4-5-34-20)21(33)31-15(2)18-10-29-23(30-11-18)24(25,26)27/h6-11,15,20H,4-5,12-13H2,1-3H3,(H,31,33)/t15-,20-/m1/s1 MROBUJILSMBILX-FOIQADDNSA-N 320181 3-{[(2R)-4-methylmorpholin-2-yl]methoxy}-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 348::US10202369, Example 348::US10472354, Example 348 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320181 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320181&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397607 384223454 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632692 C[C@@H](NC(=O)c1cc(OC[C@@H]2CN(CCO2)C(=O)OC(C)(C)C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C28H32F3N5O5S/c1-16-11-32-24(42-16)19-8-18(23(37)35-17(2)20-12-33-25(34-13-20)28(29,30)31)9-21(10-19)40-15-22-14-36(6-7-39-22)26(38)41-27(3,4)5/h8-13,17,22H,6-7,14-15H2,1-5H3,(H,35,37)/t17-,22+/m1/s1 OEKUZTDVCYAZBS-VGSWGCGISA-N 320182 Tert-butyl (2S)-2-{[3-(5-methyl-1,3-thiazol-2-yl)-5-({(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}carbamoyl)phenoxy]methyl}morpholine-4-carboxylate::US10174016, Example 349::US10202369, Example 349::US10472354, Example 349 P2X purinoceptor 3 Homo sapiens 23.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320182 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320182&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134338450 384223455 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632694 C[C@@H](NC(=O)c1cc(OC[C@@H]2CNCCO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H24F3N5O3S/c1-13-8-28-21(35-13)16-5-15(6-18(7-16)34-12-19-11-27-3-4-33-19)20(32)31-14(2)17-9-29-22(30-10-17)23(24,25)26/h5-10,14,19,27H,3-4,11-12H2,1-2H3,(H,31,32)/t14-,19+/m1/s1 HRVUBTPQOQIHTK-KUHUBIRLSA-N 320183 3-(5-Methyl-1,3-thiazol-2-yl)-5-[(2S)-morpholin-2-ylmethoxy]-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 350::US10202369, Example 350::US10472354, Example 350 P2X purinoceptor 3 Homo sapiens 14.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320183 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320183&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397343 384223456 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632696 C[C@@H](NC(=O)c1cc(OC[C@@H]2CN(C)CCO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H26F3N5O3S/c1-14-9-28-22(36-14)17-6-16(7-19(8-17)35-13-20-12-32(3)4-5-34-20)21(33)31-15(2)18-10-29-23(30-11-18)24(25,26)27/h6-11,15,20H,4-5,12-13H2,1-3H3,(H,31,33)/t15-,20+/m1/s1 MROBUJILSMBILX-QRWLVFNGSA-N 320184 3-{[(2S)-4-methylmorpholin-2-yl]methoxy}-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 351::US10202369, Example 351::US10472354, Example 351 P2X purinoceptor 3 Homo sapiens 16.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320184 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320184&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397379 384223457 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632698 C[C@@H](NC(=O)c1cc(OCC2CNCCO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H24F3N5O3S/c1-13-8-28-21(35-13)16-5-15(6-18(7-16)34-12-19-11-27-3-4-33-19)20(32)31-14(2)17-9-29-22(30-10-17)23(24,25)26/h5-10,14,19,27H,3-4,11-12H2,1-2H3,(H,31,32)/t14-,19?/m1/s1 HRVUBTPQOQIHTK-MJTSIZKDSA-N 320185 3-(5-Methyl-1,3-thiazol-2-yl)-5-[morpholin-2-ylmethoxy]-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide, Formed as a Mixture of Example 347 (Diastereoisomer 1) and Example 350 (Diastereoisomer 2)::US10174016, Example 352::US10202369, Example 352::US10472354, Example 352 P2X purinoceptor 3 Homo sapiens 18.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320185 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320185&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397625 384223458 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632700 C[C@@H](NC(=O)c1cc(OCC2CN(C)CCO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H26F3N5O3S/c1-14-9-28-22(36-14)17-6-16(7-19(8-17)35-13-20-12-32(3)4-5-34-20)21(33)31-15(2)18-10-29-23(30-11-18)24(25,26)27/h6-11,15,20H,4-5,12-13H2,1-3H3,(H,31,33)/t15-,20?/m1/s1 MROBUJILSMBILX-IWPPFLRJSA-N 320186 3-{[4-methylmorpholin-2-yl]methoxy}-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide, formed as a mixture of Example 348 (Diastereoisomer 2) and Example 351 (Diastereoisomer 1)::US10174016, Example 353::US10202369, Example 353::US10472354, Example 353 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320186 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320186&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397299 384223459 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632702 C[C@@H](NC(=O)c1cc(OCC2(F)CCCNC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H25F4N5O2S/c1-14-9-30-21(36-14)17-6-16(7-19(8-17)35-13-23(25)4-3-5-29-12-23)20(34)33-15(2)18-10-31-22(32-11-18)24(26,27)28/h6-11,15,29H,3-5,12-13H2,1-2H3,(H,33,34)/t15-,23?/m1/s1 KEYDTZMORFCFGJ-NKTHEXPSSA-N 322543 3-(Fluoropiperidin-3-yl)methoxy}-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10183937, Example 354::US10202369, Example 354 P2X purinoceptor 3 Homo sapiens 25.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322543 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322543&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134338435 384225603 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632704 C[C@H](NC(=O)c1cc(OCC2(F)CCCNC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H25F4N5O2S/c1-14-9-30-21(36-14)17-6-16(7-19(8-17)35-13-23(25)4-3-5-29-12-23)20(34)33-15(2)18-10-31-22(32-11-18)24(26,27)28/h6-11,15,29H,3-5,12-13H2,1-2H3,(H,33,34)/t15-,23?/m0/s1 KEYDTZMORFCFGJ-NGMICRHFSA-N 322544 US10183937, Example 355::US10202369, Example 355 P2X purinoceptor 3 Homo sapiens 9.00 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322544 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322544&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 138375416 384225604 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632706 C[C@@H](NC(=O)c1cc(OCC2(F)CCCN(C)C2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C25H27F4N5O2S/c1-15-10-30-22(37-15)18-7-17(8-20(9-18)36-14-24(26)5-4-6-34(3)13-24)21(35)33-16(2)19-11-31-23(32-12-19)25(27,28)29/h7-12,16H,4-6,13-14H2,1-3H3,(H,33,35)/t16-,24?/m1/s1 JEEGJUGZAOELQB-YAOANENCSA-N 322545 US10183937, Example 356::US10202369, Example 356 P2X purinoceptor 3 Homo sapiens 29.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322545 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322545&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397155 384225605 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632708 C[C@H](NC(=O)c1cc(OCC2(F)CCCN(C)C2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C25H27F4N5O2S/c1-15-10-30-22(37-15)18-7-17(8-20(9-18)36-14-24(26)5-4-6-34(3)13-24)21(35)33-16(2)19-11-31-23(32-12-19)25(27,28)29/h7-12,16H,4-6,13-14H2,1-3H3,(H,33,35)/t16-,24?/m0/s1 JEEGJUGZAOELQB-FXIRQEPWSA-N 322546 US10183937, Example 357::US10202369, Example 357 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322546 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322546&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 138375417 384225606 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632710 C[C@@H](NC(=O)c1cc(OCC2(F)CNC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C22H21F4N5O2S/c1-12-6-28-19(34-12)15-3-14(4-17(5-15)33-11-21(23)9-27-10-21)18(32)31-13(2)16-7-29-20(30-8-16)22(24,25)26/h3-8,13,27H,9-11H2,1-2H3,(H,31,32)/t13-/m1/s1 BCJGFEUMNVQMPR-CYBMUJFWSA-N 320191 3-[(3- fluoroazetidin- 3-yl)methoxy]- 5-(5-methyl- 1,3-thiazol-2- yl)-N-{(1R)-1- [2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 358::US10202369, Example 358::US10472354, Example 358 P2X purinoceptor 3 Homo sapiens 57.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320191 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320191&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397395 384223464 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632712 C[C@@H](NC(=O)c1cc(OCC2CNCCC2(F)F)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H24F5N5O2S/c1-13-8-31-21(37-13)16-5-15(6-19(7-16)36-12-18-11-30-4-3-23(18,25)26)20(35)34-14(2)17-9-32-22(33-10-17)24(27,28)29/h5-10,14,18,30H,3-4,11-12H2,1-2H3,(H,34,35)/t14-,18?/m1/s1 GMFUIUUSPXQCGC-IKJXHCRLSA-N 320192 3-{[4,4- difluoropiperidin- 3- yl]methoxy}-5- (5-methyl-1,3- thiazol-2-yl)- N-{(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide, as a mixture of 2 diastereoisomers::US10174016, Example 359::US10202369, Example 359::US10472354, Example 359 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320192 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320192&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397568 384223465 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632714 C[C@@H](NC(=O)c1cc(OC[C@H]2COCCN2C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H26F3N5O3S/c1-14-9-28-22(36-14)17-6-16(7-20(8-17)35-13-19-12-34-5-4-32(19)3)21(33)31-15(2)18-10-29-23(30-11-18)24(25,26)27/h6-11,15,19H,4-5,12-13H2,1-3H3,(H,31,33)/t15-,19-/m1/s1 QQIYVSYWBHUFSE-DNVCBOLYSA-N 320193 3-{[(3R)-4-methylmorpholin-3-yl]methoxyl}-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 360::US10202369, Example 360::US10472354, Example 360 P2X purinoceptor 3 Homo sapiens 10.00 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320193 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320193&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397664 384223466 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632716 C[C@@H](NC(=O)c1cc(OC[C@@H]2COCCN2C)cc(c1)-c1ncc(C)s1)c1ccc(nc1)C(F)(F)F InChI=1S/C25H27F3N4O3S/c1-15-11-30-24(36-15)19-8-18(9-21(10-19)35-14-20-13-34-7-6-32(20)3)23(33)31-16(2)17-4-5-22(29-12-17)25(26,27)28/h4-5,8-12,16,20H,6-7,13-14H2,1-3H3,(H,31,33)/t16-,20+/m1/s1 VDLXIDIXMUFWTI-UZLBHIALSA-N 320194 3-{[(3S)-4- methylmorpholin- 3- yl]methoxy}-5- (5-methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[6- (trifluoromethyl) pyridin-3- yl]ethyl} benzamide::US10174016, Example 361::US10202369, Example 361::US10472354, Example 361 P2X purinoceptor 3 Homo sapiens 14.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320194 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320194&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397445 384223467 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632718 C[C@@H](NC(=O)c1cc(OC[C@@H]2COCCN2C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H26F3N5O3S/c1-14-9-28-22(36-14)17-6-16(7-20(8-17)35-13-19-12-34-5-4-32(19)3)21(33)31-15(2)18-10-29-23(30-11-18)24(25,26)27/h6-11,15,19H,4-5,12-13H2,1-3H3,(H,31,33)/t15-,19+/m1/s1 QQIYVSYWBHUFSE-BEFAXECRSA-N 320195 3-{[(3S)-4- methylmorpholin- 3- yl]methoxy}-5- (5-methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyridin-5- yl]ethyl} benzamide::US10174016, Example 362::US10202369, Example 362::US10472354, Example 362 P2X purinoceptor 3 Homo sapiens 8.00 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320195 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320195&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397415 384223468 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632720 C[C@@H](NC(=O)c1cc(OC[C@H]2COCCN2C)cc(c1)-c1ncc(C)s1)c1ccc(nc1)C(F)(F)F InChI=1S/C25H27F3N4O3S/c1-15-11-30-24(36-15)19-8-18(9-21(10-19)35-14-20-13-34-7-6-32(20)3)23(33)31-16(2)17-4-5-22(29-12-17)25(26,27)28/h4-5,8-12,16,20H,6-7,13-14H2,1-3H3,(H,31,33)/t16-,20-/m1/s1 VDLXIDIXMUFWTI-OXQOHEQNSA-N 320196 3-{[(3R)-4- methylmorpholin- 3- yl]methoxy}-5- (5-methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[6- (trifluoromethyl) pyridin-3- yl]ethyl} benzamide::US10174016, Example 363::US10472354, Example 363 P2X purinoceptor 3 Homo sapiens 12.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320196 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320196&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397368 384223469 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632722 C[C@@H](NC(=O)c1cc(OCC2CC(F)CN2C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H25F4N5O2S/c1-13-8-29-22(36-13)16-4-15(5-20(6-16)35-12-19-7-18(25)11-33(19)3)21(34)32-14(2)17-9-30-23(31-10-17)24(26,27)28/h4-6,8-10,14,18-19H,7,11-12H2,1-3H3,(H,32,34)/t14-,18?,19?/m1/s1 UCQIVXMFKURDDU-FTXHTYHOSA-N 320197 3-{[4-fluoro-1- methylpyrrolidin- 2- yl]methoxy}-5- (5-methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide, as a mixture of stereoisomers::US10174016, Example 364::US10202369, Example 364::US10472354, Example 364 P2X purinoceptor 3 Homo sapiens 16.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320197 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320197&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397240 384223470 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632724 C[C@@H](NC(=O)c1cc(OCC2CC(F)CN2C)cc(c1)-c1ncc(C)s1)c1ccc(nc1)C(F)(F)F InChI=1S/C25H26F4N4O2S/c1-14-10-31-24(36-14)18-6-17(7-21(8-18)35-13-20-9-19(26)12-33(20)3)23(34)32-15(2)16-4-5-22(30-11-16)25(27,28)29/h4-8,10-11,15,19-20H,9,12-13H2,1-3H3,(H,32,34)/t15-,19?,20?/m1/s1 XNRRWTQJTXNPEU-APMMTJHUSA-N 320198 3-{[4-fluoro-1- methylpyrrolidin- 2- yl]methoxy}-5- (5-methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[6- (trifluoromethyl) pyridin-3- yl]ethyl} benzamide, as a mixture of stereoisomers::US10174016, Example 365::US10202369, Example 365::US10472354, Example 365 P2X purinoceptor 3 Homo sapiens 21.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320198 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320198&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397581 384223471 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632726 C[C@@H](NC(=O)c1cc(OC[C@H]2CN(C)CCO2)cc(c1)-c1ncc(C)s1)c1ccc(nc1)C(F)(F)F InChI=1S/C25H27F3N4O3S/c1-15-11-30-24(36-15)19-8-18(9-20(10-19)35-14-21-13-32(3)6-7-34-21)23(33)31-16(2)17-4-5-22(29-12-17)25(26,27)28/h4-5,8-12,16,21H,6-7,13-14H2,1-3H3,(H,31,33)/t16-,21-/m1/s1 PQZKBUDIGDWISA-IIBYNOLFSA-N 320199 3-{[(2R)-4-methylmorpholin-2-yl]methoxyl}-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[6-(trifluoromethyl)pyridin-3-yl]ethyl}benzamide::US10174016, Example 366::US10202369, Example 366::US10472354, Example 366 P2X purinoceptor 3 Homo sapiens 18.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320199 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320199&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397655 384223472 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632728 C[C@@H](NC(=O)c1cc(OC[C@H]2CN(C)CCO2)cc(c1)-c1ncc(Cl)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H23ClF3N5O3S/c1-13(16-8-29-22(30-9-16)23(25,26)27)31-20(33)14-5-15(21-28-10-19(24)36-21)7-17(6-14)35-12-18-11-32(2)3-4-34-18/h5-10,13,18H,3-4,11-12H2,1-2H3,(H,31,33)/t13-,18-/m1/s1 AJIHXKQJGQMCEX-FZKQIMNGSA-N 320200 3-(5-chloro- 1,3-thiazol-2- yl)-5-{[(2R)-4- methylmorpholin- 2-yl]methoxy}-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5-yl] ethyl}benzamide::US10174016, Example 367::US10202369, Example 367::US10472354, Example 367 P2X purinoceptor 3 Homo sapiens 13.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320200 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320200&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397149 384223473 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632730 CN1CCO[C@H](COc2cc(cc(c2)-c2ncc(C)s2)C(=O)NCc2cnc(nc2)C(F)(F)F)C1 InChI=1S/C23H24F3N5O3S/c1-14-8-28-21(35-14)17-5-16(6-18(7-17)34-13-19-12-31(2)3-4-33-19)20(32)27-9-15-10-29-22(30-11-15)23(24,25)26/h5-8,10-11,19H,3-4,9,12-13H2,1-2H3,(H,27,32)/t19-/m0/s1 VTYFKUULJMRVCQ-IBGZPJMESA-N 320201 3-{[(2S)-4- methylmorpholin- 2-yl]methoxy}-5- (5-methyl-1,3- thiazol-2-yl)- N-{[2- (trifluoromethyl) pyrimidin-5-yl] methyl} benzamide::US10174016, Example 368::US10202369, Example 368::US10472354, Example 368 P2X purinoceptor 3 Homo sapiens 84.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320201 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320201&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397462 384223474 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632732 C[C@@H](NC(=O)c1cc(OC[C@H]2CN(C)CCO2)cc(c1)-c1ncc(C)s1)c1ccc(nc1)C(F)F InChI=1S/C25H28F2N4O3S/c1-15-11-29-25(35-15)19-8-18(9-20(10-19)34-14-21-13-31(3)6-7-33-21)24(32)30-16(2)17-4-5-22(23(26)27)28-12-17/h4-5,8-12,16,21,23H,6-7,13-14H2,1-3H3,(H,30,32)/t16-,21-/m1/s1 YEIOEBIHIRXRPN-IIBYNOLFSA-N 320202 N-{(1R)-1-[6- (difluoromethyl) pyridin-3- yl]ethyl}-3- {[(2R)-4- methylmorpholin- 2-yl]methoxy}-5- (5-methyl-1,3- thiazol-2- yl)benzamide::US10174016, Example 369::US10202369, Example 369::US10472354, Example 369 P2X purinoceptor 3 Homo sapiens 11.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320202 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320202&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397220 384223475 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632734 C[C@@H](NC(=O)c1cc(OC[C@@H]2CN(C)CCO2)cc(c1)-c1ncc(C)s1)c1ccc(nc1)C(F)(F)F InChI=1S/C25H27F3N4O3S/c1-15-11-30-24(36-15)19-8-18(9-20(10-19)35-14-21-13-32(3)6-7-34-21)23(33)31-16(2)17-4-5-22(29-12-17)25(26,27)28/h4-5,8-12,16,21H,6-7,13-14H2,1-3H3,(H,31,33)/t16-,21+/m1/s1 PQZKBUDIGDWISA-IERDGZPVSA-N 320203 3-{[(2S)-4- methylmorpholin 2-yl]methoxy}-5- (5-methyl-1,3- thiazol-2-yl)- N-{(1R)-1-[6- (trifluoromethyl) pyridin-3- yl]ethyl} benzamide::US10174016, Example 370::US10202369, Example 370::US10472354, Example 370 P2X purinoceptor 3 Homo sapiens 41.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320203 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320203&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397778 384223476 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632736 C[C@@H](NC(=O)c1cc(OCC2(F)CN(C)C2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H23F4N5O2S/c1-13-7-28-20(35-13)16-4-15(5-18(6-16)34-12-22(24)10-32(3)11-22)19(33)31-14(2)17-8-29-21(30-9-17)23(25,26)27/h4-9,14H,10-12H2,1-3H3,(H,31,33)/t14-/m1/s1 UHPSIXSPUGVYFA-CQSZACIVSA-N 320204 3-[(3-fluoro-1- methylazetidin-3- yl}methoxy]-5- (5-methyl-1,3- thiazol-2-yl)- N-{(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 371::US10202369, Example 371::US10472354, Example 371 P2X purinoceptor 3 Homo sapiens 24.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320204 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320204&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397234 384223477 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632738 CN1CCO[C@@H](COc2cc(cc(c2)-c2ncc(C)s2)C(=O)NCc2cnc(nc2)C(F)(F)F)C1 InChI=1S/C23H24F3N5O3S/c1-14-8-28-21(35-14)17-5-16(6-18(7-17)34-13-19-12-31(2)3-4-33-19)20(32)27-9-15-10-29-22(30-11-15)23(24,25)26/h5-8,10-11,19H,3-4,9,12-13H2,1-2H3,(H,27,32)/t19-/m1/s1 VTYFKUULJMRVCQ-LJQANCHMSA-N 320205 3-{[(2R)-4- methylmorpholin- 2-yl]methoxy}-5- (5-methyl-1,3- thiazol-2-yl)- N-{[2- (trifluoromethyl) pyrimidin-5-yl] methyl} benzamide::US10174016, Example 372::US10202369, Example 372::US10472354, Example 372 P2X purinoceptor 3 Homo sapiens 19.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320205 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320205&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397797 384223478 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632740 C[C@@H](NC(=O)c1cc(OC[C@H]2CN(C)CCO2)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F InChI=1S/C24H26F3N5O3S/c1-14-11-28-23(36-14)17-8-16(9-18(10-17)35-13-19-12-32(3)6-7-34-19)22(33)29-15(2)20-4-5-21(31-30-20)24(25,26)27/h4-5,8-11,15,19H,6-7,12-13H2,1-3H3,(H,29,33)/t15-,19-/m1/s1 IJFKDPNABTXGCF-DNVCBOLYSA-N 320206 3-{[(2R)-4- methylmorpholin- 2-yl]methoxy}-5- (5-methyl-1,3- thiazol-2-yl)- N-{(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl} benzamide::US10174016, Example 373::US10202369, Example 373::US10472354, Example 373 P2X purinoceptor 3 Homo sapiens 21.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320206 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320206&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397505 384223479 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632742 C[C@@H](NC(=O)c1cc(OC[C@@H]2CN(C)CCO2)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F InChI=1S/C24H26F3N5O3S/c1-14-11-28-23(36-14)17-8-16(9-18(10-17)35-13-19-12-32(3)6-7-34-19)22(33)29-15(2)20-4-5-21(31-30-20)24(25,26)27/h4-5,8-11,15,19H,6-7,12-13H2,1-3H3,(H,29,33)/t15-,19+/m1/s1 IJFKDPNABTXGCF-BEFAXECRSA-N 320207 3-{[(2S)-4- methylmorpholin- 2-yl]methoxy}-5- (5-methyl-1,3- thiazol-2-yl)- N-{(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl} benzamide::US10174016, Example 374::US10202369, Example 374::US10472354, Example 374 P2X purinoceptor 3 Homo sapiens 55.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320207 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320207&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397406 384223480 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632744 CCc1cnc(s1)-c1cc(OC[C@@H]2CN(C)CCO2)cc(c1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C25H28F3N5O3S/c1-4-21-12-29-23(37-21)17-7-16(8-19(9-17)36-14-20-13-33(3)5-6-35-20)22(34)32-15(2)18-10-30-24(31-11-18)25(26,27)28/h7-12,15,20H,4-6,13-14H2,1-3H3,(H,32,34)/t15-,20+/m1/s1 PEGAFCGSQABLTK-QRWLVFNGSA-N 320208 3-(5-ethyl-1,3- thiazol-2-yl)-5- {[(2S)-4- methylmorpholin- 2- yl]methoxy}-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 375::US10202369, Example 375::US10472354, Example 375 P2X purinoceptor 3 Homo sapiens 11.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320208 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320208&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397736 384223481 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632746 C[C@@H](NC(=O)c1cc(OC[C@@H]2CN(C)CCO2)cc(c1)-c1ncc(Cl)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H23ClF3N5O3S/c1-13(16-8-29-22(30-9-16)23(25,26)27)31-20(33)14-5-15(21-28-10-19(24)36-21)7-17(6-14)35-12-18-11-32(2)3-4-34-18/h5-10,13,18H,3-4,11-12H2,1-2H3,(H,31,33)/t13-,18+/m1/s1 AJIHXKQJGQMCEX-ACJLOTCBSA-N 320209 3-(5-chloro- 1,3-thiazol-2- yl)-5-{[(2S)-4- methylmorpholin- 2-yl]methoxy}-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 376::US10202369, Example 376::US10472354, Example 376 P2X purinoceptor 3 Homo sapiens 32.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320209 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320209&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397674 384223482 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632748 CCc1cnc(s1)-c1cc(OC[C@H]2CN(C)CCO2)cc(c1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C25H28F3N5O3S/c1-4-21-12-29-23(37-21)17-7-16(8-19(9-17)36-14-20-13-33(3)5-6-35-20)22(34)32-15(2)18-10-30-24(31-11-18)25(26,27)28/h7-12,15,20H,4-6,13-14H2,1-3H3,(H,32,34)/t15-,20-/m1/s1 PEGAFCGSQABLTK-FOIQADDNSA-N 320210 3-(5-ethyl-1,3- thiazol-2-yl)-5- {[(2R)-4- methylmorpholin- 2-yl]methoxy}-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 377::US10202369, Example 377::US10472354, Example 377 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320210 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320210&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397144 384223483 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632750 C[C@@H](NC(=O)c1cc(OC[C@@H]2CCCN2C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H26F3N5O2S/c1-14-10-28-22(35-14)17-7-16(8-20(9-17)34-13-19-5-4-6-32(19)3)21(33)31-15(2)18-11-29-23(30-12-18)24(25,26)27/h7-12,15,19H,4-6,13H2,1-3H3,(H,31,33)/t15-,19+/m1/s1 TYUJHJGDOVFFQY-BEFAXECRSA-N 320211 3-{[(2S)-1- methylpyrrolidin- 2-yl]methoxy}-5- (5-methyl-1,3- thiazol-2-yl)- N-{(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 378::US10202369, Example 378::US10472354, Example 378 P2X purinoceptor 3 Homo sapiens 60.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320211 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320211&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397183 384223484 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632752 C[C@@H](NC(=O)c1cc(OC[C@H]2CCCN2C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H26F3N5O2S/c1-14-10-28-22(35-14)17-7-16(8-20(9-17)34-13-19-5-4-6-32(19)3)21(33)31-15(2)18-11-29-23(30-12-18)24(25,26)27/h7-12,15,19H,4-6,13H2,1-3H3,(H,31,33)/t15-,19-/m1/s1 TYUJHJGDOVFFQY-DNVCBOLYSA-N 320212 3-{[(2R)-1- methylpyrrolidin- 2-yl]methoxy}-5 (5-methyl-1,3- thiazol-2-yl)- N-{(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 379::US10202369, Example 379::US10472354, Example 379 P2X purinoceptor 3 Homo sapiens 42.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320212 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320212&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397315 384223485 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632816 CCN1CCO[C@H](COc2cc(cc(c2)-c2ncc(C)s2)C(=O)N[C@H](C)c2cnc(nc2)C(F)(F)F)C1 InChI=1S/C25H28F3N5O3S/c1-4-33-5-6-35-21(13-33)14-36-20-8-17(7-18(9-20)23-29-10-15(2)37-23)22(34)32-16(3)19-11-30-24(31-12-19)25(26,27)28/h7-12,16,21H,4-6,13-14H2,1-3H3,(H,32,34)/t16-,21+/m1/s1 IJXNJADLTIUKEL-IERDGZPVSA-N 320244 3-{[(2S)-4-ethylmorpholin-2-yl]methoxy}-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 411::US10202369, Example 411::US10472354, Example 411 P2X purinoceptor 3 Homo sapiens 20.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320244 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320244&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397533 384223516 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632818 C[C@H](NC(=O)c1cc(OC[C@H]2CN(CCO2)C(=O)OC(C)(C)C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C28H32F3N5O5S/c1-16-11-32-24(42-16)19-8-18(23(37)35-17(2)20-12-33-25(34-13-20)28(29,30)31)9-21(10-19)40-15-22-14-36(6-7-39-22)26(38)41-27(3,4)5/h8-13,17,22H,6-7,14-15H2,1-5H3,(H,35,37)/t17-,22+/m0/s1 OEKUZTDVCYAZBS-HTAPYJJXSA-N 320245 Tert-butyl (2R)-2- {[3-(5-methyl-1,3- thiazol-2-yl)-5- ({(1S)-1-[2- (trifluoromethyl) pyrimidin-5-yl] ethyl]carbamoyl) phenoxy]methyl} morpholine-4- carboxylate::US10174016, Example 412::US10202369, Example 412 P2X purinoceptor 3 Homo sapiens 687 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320245 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320245&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134338453 384223517 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632820 C[C@H](NC(=O)c1cc(OC[C@H]2CNCCO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H24F3N5O3S/c1-13-8-28-21(35-13)16-5-15(6-18(7-16)34-12-19-11-27-3-4-33-19)20(32)31-14(2)17-9-29-22(30-10-17)23(24,25)26/h5-10,14,19,27H,3-4,11-12H2,1-2H3,(H,31,32)/t14-,19+/m0/s1 HRVUBTPQOQIHTK-IFXJQAMLSA-N 320246 3-(5-methyl- 1,3-thiazol-2- yl)-5-[(2R)- morpholin-2- ylmethoxy]-N- {(1S)-1-[2- (trifluoromethyl) pyrimidin-5-yl] ethyl}benzamide::US10174016, Example 413::US10202369, Example 413::US10472354, Example 413 P2X purinoceptor 3 Homo sapiens 597 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320246 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320246&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397518 384223518 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632822 CCc1cnc(s1)-c1cc(OC[C@@H]2CNCCO2)cc(c1)C(=O)N[C@H](C)c1ccc(nn1)C(F)(F)F InChI=1S/C24H26F3N5O3S/c1-3-19-12-29-23(36-19)16-8-15(9-17(10-16)35-13-18-11-28-6-7-34-18)22(33)30-14(2)20-4-5-21(32-31-20)24(25,26)27/h4-5,8-10,12,14,18,28H,3,6-7,11,13H2,1-2H3,(H,30,33)/t14-,18+/m1/s1 PAVCMPZQEBSSQV-KDOFPFPSSA-N 320247 3-(5-ethyl-1,3- thiazol-2-yl)-5- [(2S)- morpholin-2- ylmethoxy]-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3-yl] ethyl}benzamide::US10174016, Example 414::US10202369, Example 414::US10472354, Example 414 P2X purinoceptor 3 Homo sapiens 29.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320247 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320247&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397150 384223519 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632824 CCc1cnc(s1)-c1cc(OC[C@H]2CNCCO2)cc(c1)C(=O)N[C@H](C)c1ccc(nn1)C(F)(F)F InChI=1S/C24H26F3N5O3S/c1-3-19-12-29-23(36-19)16-8-15(9-17(10-16)35-13-18-11-28-6-7-34-18)22(33)30-14(2)20-4-5-21(32-31-20)24(25,26)27/h4-5,8-10,12,14,18,28H,3,6-7,11,13H2,1-2H3,(H,30,33)/t14-,18-/m1/s1 PAVCMPZQEBSSQV-RDTXWAMCSA-N 320248 3-(5-ethyl-1,3- thiazol-2-yl)-5- [(2R)- morpholin-2- ylmethoxy]-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3-yl] ethyl}benzamide::US10174016, Example 415::US10202369, Example 415::US10472354, Example 415 P2X purinoceptor 3 Homo sapiens 10.00 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320248 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320248&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397550 384223520 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632826 C[C@H](NC(=O)c1cc(OC[C@H]2CN(C)CCO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H26F3N5O3S/c1-14-9-28-22(36-14)17-6-16(7-19(8-17)35-13-20-12-32(3)4-5-34-20)21(33)31-15(2)18-10-29-23(30-11-18)24(25,26)27/h6-11,15,20H,4-5,12-13H2,1-3H3,(H,31,33)/t15-,20+/m0/s1 MROBUJILSMBILX-MGPUTAFESA-N 320249 3-{[(2R)-4- methylmorpholin- 2-yl]methoxy}- 5-(5-methyl-1,3- thiazol-2-yl)- N-{(1S)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 416::US10202369, Example 416 P2X purinoceptor 3 Homo sapiens 227 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320249 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320249&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397764 384223521 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632828 C[C@H](NC(=O)c1cc(OC[C@@H]2CN(C)CCO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H26F3N5O3S/c1-14-9-28-22(36-14)17-6-16(7-19(8-17)35-13-20-12-32(3)4-5-34-20)21(33)31-15(2)18-10-29-23(30-11-18)24(25,26)27/h6-11,15,20H,4-5,12-13H2,1-3H3,(H,31,33)/t15-,20-/m0/s1 MROBUJILSMBILX-YWZLYKJASA-N 320250 3-{[(2S)-4- methylmorpholin- 2-yl]methoxy}- 5-(5-methyl-1,3- thiazol-2-yl)- N-{(1S)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 417::US10202369, Example 417 P2X purinoceptor 3 Homo sapiens 434 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320250 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320250&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397582 384223522 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632830 CCc1cnc(s1)-c1cc(OC[C@@H]2CN(C)CCO2)cc(c1)C(=O)N[C@H](C)c1ccc(nn1)C(F)(F)F InChI=1S/C25H28F3N5O3S/c1-4-20-12-29-24(37-20)17-9-16(10-18(11-17)36-14-19-13-33(3)7-8-35-19)23(34)30-15(2)21-5-6-22(32-31-21)25(26,27)28/h5-6,9-12,15,19H,4,7-8,13-14H2,1-3H3,(H,30,34)/t15-,19+/m1/s1 SIFMRPZFMXLARV-BEFAXECRSA-N 322607 3-(5-Ethyl-1,3- thiazol-2-yl)-5- {[(2S)-4- methyl- morpholin-2- yl]methoxy}-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl} benzamide::US10183937, Example 418::US10202369, Example 418::US10472354, Example 418 P2X purinoceptor 3 Homo sapiens 23.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322607 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322607&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397330 384225667 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632832 CCc1cnc(s1)-c1cc(OC[C@H]2CN(C)CCO2)cc(c1)C(=O)N[C@H](C)c1ccc(nn1)C(F)(F)F InChI=1S/C25H28F3N5O3S/c1-4-20-12-29-24(37-20)17-9-16(10-18(11-17)36-14-19-13-33(3)7-8-35-19)23(34)30-15(2)21-5-6-22(32-31-21)25(26,27)28/h5-6,9-12,15,19H,4,7-8,13-14H2,1-3H3,(H,30,34)/t15-,19-/m1/s1 SIFMRPZFMXLARV-DNVCBOLYSA-N 322608 3-(5-ethyl-1,3- thiazol-2-yl)-5- {[(2R)-4- methyl- morpholin-2- yl]methoxy}-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl} benzamide::US10183937, Example 419::US10202369, Example 419::US10472354, Example 419 P2X purinoceptor 3 Homo sapiens 9.00 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322608 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322608&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397262 384225668 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632754 C[C@@H](NC(=O)c1cc(OCC2CCN(C)CC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C25H28F3N5O2S/c1-15-11-29-23(36-15)19-8-18(9-21(10-19)35-14-17-4-6-33(3)7-5-17)22(34)32-16(2)20-12-30-24(31-13-20)25(26,27)28/h8-13,16-17H,4-7,14H2,1-3H3,(H,32,34)/t16-/m1/s1 GQMGTASPVLCRIR-MRXNPFEDSA-N 320213 3-[(1- methylpiperidin- 4-yl)methoxy]-5- (5-methyl-1,3- thiazol-2-yl)- N-{(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 380::US10202369, Example 380::US10472354, Example 380 P2X purinoceptor 3 Homo sapiens 32.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320213 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320213&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397264 384223486 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632756 CC(C)N1CCO[C@@H](COc2cc(cc(c2)-c2ncc(C)s2)C(=O)N[C@H](C)c2cnc(nc2)C(F)(F)F)C1 InChI=1S/C26H30F3N5O3S/c1-15(2)34-5-6-36-22(13-34)14-37-21-8-18(7-19(9-21)24-30-10-16(3)38-24)23(35)33-17(4)20-11-31-25(32-12-20)26(27,28)29/h7-12,15,17,22H,5-6,13-14H2,1-4H3,(H,33,35)/t17-,22-/m1/s1 AOHBYHNFISDLHQ-VGOFRKELSA-N 320214 3-(5-methyl- 1,3-thiazol-2- yl)-5-{[(2R)-4- (propan-2- yl)morpholin- 2-yl]methoxy}- N-{(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 381::US10202369, Example 381::US10472354, Example 381 P2X purinoceptor 3 Homo sapiens 16.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320214 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320214&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397576 384223487 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632758 CC(C)N1CCO[C@H](COc2cc(cc(c2)-c2ncc(C)s2)C(=O)N[C@H](C)c2cnc(nc2)C(F)(F)F)C1 InChI=1S/C26H30F3N5O3S/c1-15(2)34-5-6-36-22(13-34)14-37-21-8-18(7-19(9-21)24-30-10-16(3)38-24)23(35)33-17(4)20-11-31-25(32-12-20)26(27,28)29/h7-12,15,17,22H,5-6,13-14H2,1-4H3,(H,33,35)/t17-,22+/m1/s1 AOHBYHNFISDLHQ-VGSWGCGISA-N 320215 3-(5-methyl- 1,3-thiazol-2- yl)-5-{[(2R)-4- (propan-2- yl)morpholin- 2-yl]methoxy}- N-{(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 382::US10202369, Example 382::US10472354, Example 382 P2X purinoceptor 3 Homo sapiens 13.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320215 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320215&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397421 384223488 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632760 C[C@@H](NC(=O)c1cc(OCC2CN(C)CCC2(F)F)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C25H26F5N5O2S/c1-14-9-31-22(38-14)17-6-16(7-20(8-17)37-13-19-12-35(3)5-4-24(19,26)27)21(36)34-15(2)18-10-32-23(33-11-18)25(28,29)30/h6-11,15,19H,4-5,12-13H2,1-3H3,(H,34,36)/t15-,19?/m1/s1 LGPVNMAGAZJDEW-NYRJJRHWSA-N 320216 3-{[4,4- difluoro-1- methylpiperidin- 3-yl]methoxy}-5- (5-methyl-1,3- thiazol-2-yl)- N-{(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide, as a mixture of 2 diastereoisomers::US10174016, Example 383::US10202369, Example 384::US10472354, Example 383 P2X purinoceptor 3 Homo sapiens 2.00 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320216 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320216&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397497 384223489 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632762 C[C@@H](NC(=O)c1cc(OCC2CN(C)CCC2(F)F)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C25H26F5N5O2S/c1-14-9-31-22(38-14)17-6-16(7-20(8-17)37-13-19-12-35(3)5-4-24(19,26)27)21(36)34-15(2)18-10-32-23(33-11-18)25(28,29)30/h6-11,15,19H,4-5,12-13H2,1-3H3,(H,34,36)/t15-,19?/m1/s1 LGPVNMAGAZJDEW-NYRJJRHWSA-N 320216 3-{[4,4- difluoro-1- methylpiperidin- 3-yl]methoxy}-5- (5-methyl-1,3- thiazol-2-yl)- N-{(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide, as a mixture of 2 diastereoisomers::US10174016, Example 383::US10202369, Example 384::US10472354, Example 383 P2X purinoceptor 3 Homo sapiens 3.00 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320216 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320216&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397497 384223489 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632764 C[C@H](NC(=O)c1cc(OCC2CN(C)CCC2(F)F)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C25H26F5N5O2S/c1-14-9-31-22(38-14)17-6-16(7-20(8-17)37-13-19-12-35(3)5-4-24(19,26)27)21(36)34-15(2)18-10-32-23(33-11-18)25(28,29)30/h6-11,15,19H,4-5,12-13H2,1-3H3,(H,34,36)/t15-,19?/m0/s1 LGPVNMAGAZJDEW-FUKCDUGKSA-N 322574 US10183937, Example 385::US10202369, Example 385 P2X purinoceptor 3 Homo sapiens 3.00 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322574 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322574&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 138375418 384225634 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632766 C[C@@H](NC(=O)c1cc(OCC2(F)CN(C)C2)cc(c1)-c1ncc(C)s1)c1ccc(nc1)C(F)(F)F InChI=1S/C24H24F4N4O2S/c1-14-9-30-22(35-14)18-6-17(7-19(8-18)34-13-23(25)11-32(3)12-23)21(33)31-15(2)16-4-5-20(29-10-16)24(26,27)28/h4-10,15H,11-13H2,1-3H3,(H,31,33)/t15-/m1/s1 YWRAMSXXAJRPGK-OAHLLOKOSA-N 320219 3-[(3-fluoro-1- methylazetidin-3- yl)methoxy]-5-(5- methyl-1,3-thiazol- 2-yl)-N-{(1R)-1-[6- (trifluoromethyl) pyridin-3-yl] ethyl}benzamide::US10174016, Example 386::US10202369, Example 386::US10472354, Example 386 P2X purinoceptor 3 Homo sapiens 24.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320219 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320219&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397321 384223491 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632768 CCc1cnc(s1)-c1cc(OCC2(F)CN(C)C2)cc(c1)C(=O)N[C@H](C)c1ccc(nc1)C(F)(F)F InChI=1S/C25H26F4N4O2S/c1-4-20-11-31-23(36-20)18-7-17(8-19(9-18)35-14-24(26)12-33(3)13-24)22(34)32-15(2)16-5-6-21(30-10-16)25(27,28)29/h5-11,15H,4,12-14H2,1-3H3,(H,32,34)/t15-/m1/s1 HCTVCZSENAWJEB-OAHLLOKOSA-N 320220 3-(5-ethyl-1,3- thiazol-2-yl)-5-[(3- fluoro-1- methylazetidin-3- yl)methoxy]-N- {(1R)-1-[6- (trifluoromethyl) pyridin-3-yl] ethyl}benzamide::US10174016, Example 387::US10202369, Example 387::US10472354, Example 387 P2X purinoceptor 3 Homo sapiens 19.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320220 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320220&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397751 384223492 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632770 C[C@@H](NC(=O)c1cc(OC[C@H]2COCCN2C)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F InChI=1S/C24H26F3N5O3S/c1-14-11-28-23(36-14)17-8-16(9-19(10-17)35-13-18-12-34-7-6-32(18)3)22(33)29-15(2)20-4-5-21(31-30-20)24(25,26)27/h4-5,8-11,15,18H,6-7,12-13H2,1-3H3,(H,29,33)/t15-,18-/m1/s1 SOWWCICJAYGBSY-CRAIPNDOSA-N 320221 3-{[(3R)-4- methylmorpholin-3- yl]methoxy}-5-(5- methyl-1,3-thiazol- 2-yl)-N-{(1R)-1-[6- (trifluoromethyl) pyridazin-3-yl] ethyl}benzamide::US10174016, Example 388::US10202369, Example 388::US10472354, Example 388 P2X purinoceptor 3 Homo sapiens 18.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320221 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320221&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397768 384223493 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632772 C[C@@H](NC(=O)c1cc(OC[C@@H]2COCCN2C)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F InChI=1S/C24H26F3N5O3S/c1-14-11-28-23(36-14)17-8-16(9-19(10-17)35-13-18-12-34-7-6-32(18)3)22(33)29-15(2)20-4-5-21(31-30-20)24(25,26)27/h4-5,8-11,15,18H,6-7,12-13H2,1-3H3,(H,29,33)/t15-,18+/m1/s1 SOWWCICJAYGBSY-QAPCUYQASA-N 320222 3-{[(3S)-4- methylmorpholin-3- yl]methoxy}-5-(5- methyl-1,3-thiazol- 2-yl)-N-{(1R)-1-[6- (trifluoromethyl) pyridazin-3-yl] ethyl}benzamide::US10174016, Example 389::US10202369, Example 389::US10472354, Example 389 P2X purinoceptor 3 Homo sapiens 18.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320222 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320222&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397449 384223494 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632774 CCN1CCO[C@@H](COc2cc(cc(c2)-c2ncc(C)s2)C(=O)N[C@H](C)c2cnc(nc2)C(F)(F)F)C1 InChI=1S/C25H28F3N5O3S/c1-4-33-5-6-35-21(13-33)14-36-20-8-17(7-18(9-20)23-29-10-15(2)37-23)22(34)32-16(3)19-11-30-24(31-12-19)25(26,27)28/h7-12,16,21H,4-6,13-14H2,1-3H3,(H,32,34)/t16-,21-/m1/s1 IJXNJADLTIUKEL-IIBYNOLFSA-N 320223 3-{[(2R)-4-ethylmorpholin-2-yl]methoxy}-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 390::US10202369, Example 390::US10472354, Example 390 P2X purinoceptor 3 Homo sapiens 17.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320223 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320223&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397822 384223495 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632776 C[C@@H](NC(=O)c1cc(OC[C@H]2CN(CC(F)F)CCO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C25H26F5N5O3S/c1-14-8-31-23(39-14)17-5-16(22(36)34-15(2)18-9-32-24(33-10-18)25(28,29)30)6-19(7-17)38-13-20-11-35(3-4-37-20)12-21(26)27/h5-10,15,20-21H,3-4,11-13H2,1-2H3,(H,34,36)/t15-,20-/m1/s1 LANXVVYUHZPONS-FOIQADDNSA-N 320224 3-{[(2R)-4-(2,2-difluoroethyl)morpholin-2-yl]methoxy}-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 391::US10202369, Example 391::US10472354, Example 391 P2X purinoceptor 3 Homo sapiens 19.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320224 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320224&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397746 384223496 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632778 COC(=O)N1CCO[C@@H](COc2cc(cc(c2)-c2ncc(C)s2)C(=O)N[C@H](C)c2cnc(nc2)C(F)(F)F)C1 InChI=1S/C25H26F3N5O5S/c1-14-9-29-22(39-14)17-6-16(21(34)32-15(2)18-10-30-23(31-11-18)25(26,27)28)7-19(8-17)38-13-20-12-33(4-5-37-20)24(35)36-3/h6-11,15,20H,4-5,12-13H2,1-3H3,(H,32,34)/t15-,20-/m1/s1 AMNDVZJYNBRGRX-FOIQADDNSA-N 320225 Methyl (2R)-2-{[3-(5-methyl-1,3-thiazol-2-yl)-5-({(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}carbamoyl)phenoxy]methyl}morpholine-4-carboxylate::US10174016, Example 392::US10202369, Example 392::US10472354, Example 392 P2X purinoceptor 3 Homo sapiens 11.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320225 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320225&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134338451 384223497 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632780 COC(=O)N1CCO[C@H](COc2cc(cc(c2)-c2ncc(C)s2)C(=O)N[C@H](C)c2cnc(nc2)C(F)(F)F)C1 InChI=1S/C25H26F3N5O5S/c1-14-9-29-22(39-14)17-6-16(21(34)32-15(2)18-10-30-23(31-11-18)25(26,27)28)7-19(8-17)38-13-20-12-33(4-5-37-20)24(35)36-3/h6-11,15,20H,4-5,12-13H2,1-3H3,(H,32,34)/t15-,20+/m1/s1 AMNDVZJYNBRGRX-QRWLVFNGSA-N 320226 Methyl (2S)-2- {[3-(5-methyl- 1,3-thiazol-2- yl)-5-({(1R)-1- [2- (trifluoromethyl) pyrimidin-5-yl] ethyl}carbamoyl) phenoxy]methyl} morpholine-4- carboxylate::US10174016, Example 393::US10202369, Example 393::US10472354, Example 393 P2X purinoceptor 3 Homo sapiens 24.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320226 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320226&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134338452 384223498 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632782 C[C@@H](NC(=O)c1cc(OCC2CNC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C22H22F3N5O2S/c1-12-6-27-20(33-12)16-3-15(4-18(5-16)32-11-14-7-26-8-14)19(31)30-13(2)17-9-28-21(29-10-17)22(23,24)25/h3-6,9-10,13-14,26H,7-8,11H2,1-2H3,(H,30,31)/t13-/m1/s1 MHYFOJHMKOGSKR-CYBMUJFWSA-N 320227 3-(Azetidin-3-ylmethoxy)-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 394::US10202369, Example 394::US10472354, Example 394 P2X purinoceptor 3 Homo sapiens 82.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320227 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320227&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397376 384223499 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632784 C[C@@H](NC(=O)c1cc(OC[C@H]2COCC(=O)N2C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H24F3N5O4S/c1-13-7-28-22(37-13)16-4-15(5-19(6-16)36-11-18-10-35-12-20(33)32(18)3)21(34)31-14(2)17-8-29-23(30-9-17)24(25,26)27/h4-9,14,18H,10-12H2,1-3H3,(H,31,34)/t14-,18-/m1/s1 SDFLFPYVVNTAIN-RDTXWAMCSA-N 320228 3-{[(3R)-4-methyl-5-oxomorpholin-3-yl]methoxyl}-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 395::US10202369, Example 395::US10472354, Example 395 P2X purinoceptor 3 Homo sapiens 30.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320228 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320228&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397767 384223500 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632786 C[C@@H](NC(=O)c1cc(OC[C@H]2COCC(=O)N2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H22F3N5O4S/c1-12-6-27-21(36-12)15-3-14(4-18(5-15)35-10-17-9-34-11-19(32)31-17)20(33)30-13(2)16-7-28-22(29-8-16)23(24,25)26/h3-8,13,17H,9-11H2,1-2H3,(H,30,33)(H,31,32)/t13-,17-/m1/s1 QBCIMXIDQXCQLC-CXAGYDPISA-N 320229 3-(5-methyl-1,3- thiazol-2-yl)-5- {[(3R)-5- oxomorpholin-3- yl]methoxy}-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5-yl] ethyl}benzamide::US10174016, Example 396::US10202369, Example 396::US10472354, Example 396 P2X purinoceptor 3 Homo sapiens 22.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320229 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320229&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397733 384223501 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632788 C[C@@H](NC(=O)c1cc(OC[C@@H]2CN(C)C(=O)O2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H22F3N5O4S/c1-12-7-27-20(36-12)15-4-14(5-17(6-15)34-11-18-10-31(3)22(33)35-18)19(32)30-13(2)16-8-28-21(29-9-16)23(24,25)26/h4-9,13,18H,10-11H2,1-3H3,(H,30,32)/t13-,18+/m1/s1 OAEQMLBAMDEFGR-ACJLOTCBSA-N 320230 3-{[(5S)-3-methyl-2- oxo-1,3-oxazolidin- 5-yl]methoxy}-5-(5- methyl-1,3-thiazol- 2-yl)-N-{(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 397::US10202369, Example 397::US10472354, Example 397 P2X purinoceptor 3 Homo sapiens 15.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320230 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320230&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397304 384223502 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632790 C[C@@H](NC(=O)c1cc(OC[C@H]2CN(C)C(=O)O2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H22F3N5O4S/c1-12-7-27-20(36-12)15-4-14(5-17(6-15)34-11-18-10-31(3)22(33)35-18)19(32)30-13(2)16-8-28-21(29-9-16)23(24,25)26/h4-9,13,18H,10-11H2,1-3H3,(H,30,32)/t13-,18-/m1/s1 OAEQMLBAMDEFGR-FZKQIMNGSA-N 320231 3-{[(5R)-3-methyl-2- oxo-1,3-oxazolidin- 5-yl]methoxy}-5-(5- methyl-1,3-thiazol- 2-yl)-N-{(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 398::US10202369, Example 398::US10472354, Example 398 P2X purinoceptor 3 Homo sapiens 17.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320231 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320231&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397297 384223503 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632792 C[C@@H](NC(=O)c1cc(OC[C@H]2CN(C)C(=O)CO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H24F3N5O4S/c1-13-7-28-22(37-13)16-4-15(5-18(6-16)35-11-19-10-32(3)20(33)12-36-19)21(34)31-14(2)17-8-29-23(30-9-17)24(25,26)27/h4-9,14,19H,10-12H2,1-3H3,(H,31,34)/t14-,19-/m1/s1 UCMZCPXWJACEJN-AUUYWEPGSA-N 320232 3-{[(2R)-4-methyl-5- oxomorpholin-2-yl] methoxy}-5-(5- methyl-1,3-thiazol- 2-yl)-N-{(1R)-1-[2- (trifluoromethyl) pyrimidin-5-yl] ethyl}benzamide::US10174016, Example 399::US10202369, Example 399::US10472354, Example 399 P2X purinoceptor 3 Homo sapiens 69.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320232 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320232&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397565 384223504 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632794 C[C@@H](NC(=O)c1cc(OC[C@@H]2CNC(=O)CO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H22F3N5O4S/c1-12-6-28-21(36-12)15-3-14(4-17(5-15)34-10-18-9-27-19(32)11-35-18)20(33)31-13(2)16-7-29-22(30-8-16)23(24,25)26/h3-8,13,18H,9-11H2,1-2H3,(H,27,32)(H,31,33)/t13-,18+/m1/s1 SQKDWNUUISQXQF-ACJLOTCBSA-N 320233 3-(5-methyl-1,3- thiazol-2-yl)-5- {[(2S)-5- oxomorpholin-2- yl]methoxy}-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 400::US10202369, Example 400::US10472354, Example 400 P2X purinoceptor 3 Homo sapiens 59.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320233 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320233&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397173 384223505 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632796 C[C@@H](NC(=O)c1cc(OC[C@@H]2CN(C)C(=O)CO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H24F3N5O4S/c1-13-7-28-22(37-13)16-4-15(5-18(6-16)35-11-19-10-32(3)20(33)12-36-19)21(34)31-14(2)17-8-29-23(30-9-17)24(25,26)27/h4-9,14,19H,10-12H2,1-3H3,(H,31,34)/t14-,19+/m1/s1 UCMZCPXWJACEJN-KUHUBIRLSA-N 320234 3-{[(2S)-4-methyl-5- oxomorpholin-2-yl] methoxy}-5-(5- methyl-1,3-thiazol- 2-yl)-N-{(1R)-1-[2- (trifluoromethyl) pyrimidin-5-yl] ethyl}benzamide::US10174016, Example 401::US10202369, Example 401::US10472354, Example 401 P2X purinoceptor 3 Homo sapiens 30.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320234 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320234&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397710 384223506 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632798 C[C@@H](NC(=O)c1cc(OC[C@@H]2COCC(=O)N2C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H24F3N5O4S/c1-13-7-28-22(37-13)16-4-15(5-19(6-16)36-11-18-10-35-12-20(33)32(18)3)21(34)31-14(2)17-8-29-23(30-9-17)24(25,26)27/h4-9,14,18H,10-12H2,1-3H3,(H,31,34)/t14-,18+/m1/s1 SDFLFPYVVNTAIN-KDOFPFPSSA-N 320235 3-{[(3S)-4-methyl-5- oxomorpholin-3-yl] methoxy}-5-(5- methyl-1,3-thiazol- 2-yl)-N-{(1R)-1-[2- (trifluoromethyl) pyrimidin-5-yl] ethyl}benzamide::US10174016, Example 402::US10472354, Example 402 P2X purinoceptor 3 Homo sapiens 21.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320235 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320235&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397212 384223507 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632800 C[C@@H](NC(=O)c1cc(OC[C@@H]2COCC(=O)N2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H22F3N5O4S/c1-12-6-27-21(36-12)15-3-14(4-18(5-15)35-10-17-9-34-11-19(32)31-17)20(33)30-13(2)16-7-28-22(29-8-16)23(24,25)26/h3-8,13,17H,9-11H2,1-2H3,(H,30,33)(H,31,32)/t13-,17+/m1/s1 QBCIMXIDQXCQLC-DYVFJYSZSA-N 320236 3-(5-methyl-1,3- thiazol-2-yl)-5- {[(3S)-5- oxomorpholin-3- yl]methoxy}-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 403::US10472354, Example 403 P2X purinoceptor 3 Homo sapiens 56.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320236 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320236&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397456 384223508 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632802 C[C@@H](NC(=O)c1cc(OCC23CC(CO2)N(C3)C(=O)OC(C)(C)C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C29H32F3N5O5S/c1-16-10-33-24(43-16)19-6-18(23(38)36-17(2)20-11-34-25(35-12-20)29(30,31)32)7-22(8-19)40-15-28-9-21(13-41-28)37(14-28)26(39)42-27(3,4)5/h6-8,10-12,17,21H,9,13-15H2,1-5H3,(H,36,38)/t17-,21?,28?/m1/s1 FPSSQFUABOQNNZ-RWNQLPSJSA-N 320237 US10174016, Example 404::US10202369, Example 404::US10472354, Example 404::tert-butyl 1-{[3-(5- methyl-1,3-thiazol- 2-yl)-5-({(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}carbamoyl) phenoxy]methyl}-2- oxa-5- azabicyclo[2.2.1] heptane-5- carboxylate, as a mixture of 2 diastereoisomers P2X purinoceptor 3 Homo sapiens 44.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320237 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320237&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397508 384223509 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632804 CC(C)N1CC2(COc3cc(cc(c3)-c3ncc(C)s3)C(=O)N[C@H](C)c3cnc(nc3)C(F)(F)F)CC1CO2 InChI=1S/C27H30F3N5O3S/c1-15(2)35-13-26(8-21(35)12-38-26)14-37-22-6-18(5-19(7-22)24-31-9-16(3)39-24)23(36)34-17(4)20-10-32-25(33-11-20)27(28,29)30/h5-7,9-11,15,17,21H,8,12-14H2,1-4H3,(H,34,36)/t17-,21?,26?/m1/s1 YPUYZHJKGABFEF-XJNIYMOYSA-N 320238 3-[(5-isopropyl-2- oxa-5-azabicyclo [2.2.1]hept-1-yl) methoxy]-5- (5-methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide, as a mixture of 2 diastereoisomers::US10174016, Example 405::US10202369, Example 405::US10472354, Example 405 P2X purinoceptor 3 Homo sapiens 17.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320238 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320238&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397496 384223510 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632806 C[C@@H](NC(=O)c1cc(OCC23CC(CO2)N(C)C3)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C25H26F3N5O3S/c1-14-8-29-22(37-14)17-4-16(5-20(6-17)35-13-24-7-19(11-36-24)33(3)12-24)21(34)32-15(2)18-9-30-23(31-10-18)25(26,27)28/h4-6,8-10,15,19H,7,11-13H2,1-3H3,(H,32,34)/t15-,19?,24?/m1/s1 QZIIXNSQPLEQAW-QOFOLWBBSA-N 320239 3-[(5-methyl-2- oxa-5-azabicyclo [2.2.1]hept-1-yl) methoxy]-5- (5-methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide, as a mixture of 2 diastereoisomers::US10174016, Example 406::US10202369, Example 406::US10472354, Example 406 P2X purinoceptor 3 Homo sapiens 26.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320239 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320239&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397318 384223511 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632808 C[C@@H](NC(=O)c1cc(OCC23CNC(CO2)C3)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H24F3N5O3S/c1-13-7-28-21(36-13)16-3-15(4-19(5-16)34-12-23-6-18(10-35-23)31-11-23)20(33)32-14(2)17-8-29-22(30-9-17)24(25,26)27/h3-5,7-9,14,18,31H,6,10-12H2,1-2H3,(H,32,33)/t14-,18?,23?/m1/s1 NAZJZFLNXXGFCR-IHDUPTFDSA-N 320240 3-(5-Methyl-1,3-thiazol-2-yl)-5-[2-oxa-5-azabicyclo[2.2.1]hept-1-ylmethoxy]-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide, as a Mixture of 2 Diastereoisomers::US10174016, Example 407::US10202369, Example 407::US10472354, Example 407 P2X purinoceptor 3 Homo sapiens 15.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320240 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320240&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397648 384223512 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632810 CCCN1CC2(COc3cc(cc(c3)-c3ncc(C)s3)C(=O)N[C@H](C)c3cnc(nc3)C(F)(F)F)CC1CO2 InChI=1S/C27H30F3N5O3S/c1-4-5-35-14-26(9-21(35)13-38-26)15-37-22-7-18(6-19(8-22)24-31-10-16(2)39-24)23(36)34-17(3)20-11-32-25(33-12-20)27(28,29)30/h6-8,10-12,17,21H,4-5,9,13-15H2,1-3H3,(H,34,36)/t17-,21?,26?/m1/s1 AAPJJGZIWGLKBD-XJNIYMOYSA-N 320241 3-(5-methyl-1,3- thiazol-2-yl)-5-[(5- propyl-2- oxa-5-azabicyclo [2.2.1]hept-1-yl) methoxy]-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide, as a mixture of 2 diastereoisomers::US10174016, Example 408::US10202369, Example 408::US10472354, Example 408 P2X purinoceptor 3 Homo sapiens 32.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320241 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320241&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397789 384223513 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632812 COC(=O)N1CC2(COc3cc(cc(c3)-c3ncc(C)s3)C(=O)N[C@H](C)c3cnc(nc3)C(F)(F)F)CC1CO2 InChI=1S/C26H26F3N5O5S/c1-14-8-30-22(40-14)17-4-16(21(35)33-15(2)18-9-31-23(32-10-18)26(27,28)29)5-20(6-17)38-13-25-7-19(11-39-25)34(12-25)24(36)37-3/h4-6,8-10,15,19H,7,11-13H2,1-3H3,(H,33,35)/t15-,19?,25?/m1/s1 ACUSXDHHFJWBEG-QYRGRQSGSA-N 320242 Methyl 1-{[3-(5-methyl-1,3-thiazol-2-yl)-5-({(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}carbamoyl)phenoxy]methyl}-2-oxa-5-azabicyclo[2.2.1]heptane-5-carboxylate, as a mixture of 2 diastereoisomers::US10174016, Example 409::US10202369, Example 409::US10472354, Example 409 P2X purinoceptor 3 Homo sapiens 22.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320242 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320242&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397200 384223514 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 632814 CCOC(=O)N1CC2(COc3cc(cc(c3)-c3ncc(C)s3)C(=O)N[C@H](C)c3cnc(nc3)C(F)(F)F)CC1CO2 InChI=1S/C27H28F3N5O5S/c1-4-38-25(37)35-13-26(8-20(35)12-40-26)14-39-21-6-17(5-18(7-21)23-31-9-15(2)41-23)22(36)34-16(3)19-10-32-24(33-11-19)27(28,29)30/h5-7,9-11,16,20H,4,8,12-14H2,1-3H3,(H,34,36)/t16-,20?,26?/m1/s1 MVNNYWBQRAUUBD-ORALUJHKSA-N 320243 Ethyl 1-{[3-(5-methyl-1,3-thiazol-2-yl)-5-({(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}carbamoyl)phenoxy]methyl}-2-oxa-5-azabicyclo[2.2.1]heptane-5-carboxylate, as a Mixture of 2 Diastereoisomers::US10174016, Example 410::US10202369, Example 410::US10472354, Example 410 P2X purinoceptor 3 Homo sapiens 22.0 US Patent 10.7270/Q2028TNS aid1796696 US10183937 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320243 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320243&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397180 384223515 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655348 CC(C)(Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ncccc3F)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O InChI=1S/C26H23ClFN5O5/c1-26(2,22(34)35)15-33-24(36)31-23(32(25(33)37)14-16-5-7-17(27)8-6-16)30-18-9-11-19(12-10-18)38-21-20(28)4-3-13-29-21/h3-13H,14-15H2,1-2H3,(H,34,35)(H,30,31,36) GKDSFPBNRMQVRT-UHFFFAOYSA-N 271508 US10065941, Compound I-009::US9732060, Compound I-009 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271508 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271508&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295394 378153336 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655349 CC(C)(Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(F)n3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O InChI=1S/C26H23ClFN5O5/c1-26(2,22(34)35)15-33-24(36)31-23(32(25(33)37)14-16-6-8-17(27)9-7-16)29-18-10-12-19(13-11-18)38-21-5-3-4-20(28)30-21/h3-13H,14-15H2,1-2H3,(H,34,35)(H,29,31,36) OOQKMULDJFIQNR-UHFFFAOYSA-N 271509 US10065941, Compound I-010::US9732060, Compound I-010 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271509 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271509&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752308 378153337 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655350 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(Cl)n3)cc2)n(Cc2ccc(Cl)cc2)c1=O 271510 US10065941, Compound I-011::US9732060, Compound I-011 P2X purinoceptor 3 Homo sapiens 18.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271510 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271510&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295395 378153338 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655351 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(Cl)n3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C27H25Cl2N5O5/c1-27(2,23(35)38-3)16-34-25(36)32-24(33(26(34)37)15-17-7-9-18(28)10-8-17)30-19-11-13-20(14-12-19)39-22-6-4-5-21(29)31-22/h4-14H,15-16H2,1-3H3,(H,30,32,36) MAAXYLWWFYPLSU-UHFFFAOYSA-N 271511 US10065941, Compound I-012::US9732060, Compound I-012 P2X purinoceptor 3 Homo sapiens 25.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271511 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271511&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295396 378153339 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655352 COC(=O)[C@H](C)[C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(Cl)n3)cc2)n(Cc2ccc(Cl)cc2)c1=O 271512 US10065941, Compound I-013::US9732060, Compound I-013 P2X purinoceptor 3 Homo sapiens 58.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271512 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271512&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295397 378153340 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655353 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(Cl)n3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271513 US10065941, Compound I-014::US9732060, Compound I-014 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271513 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271513&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 86292818 378153341 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655354 CC(C)(Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(Cl)n3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O InChI=1S/C26H23Cl2N5O5/c1-26(2,22(34)35)15-33-24(36)31-23(32(25(33)37)14-16-6-8-17(27)9-7-16)29-18-10-12-19(13-11-18)38-21-5-3-4-20(28)30-21/h3-13H,14-15H2,1-2H3,(H,34,35)(H,29,31,36) PBXBAMBZPWHRPG-UHFFFAOYSA-N 271514 US10065941, Compound I-015::US9732060, Compound I-015 P2X purinoceptor 3 Homo sapiens 9.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271514 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271514&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752280 378153342 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655355 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(Cl)n3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271515 US10065941, Compound I-016::US9732060, Compound I-016 P2X purinoceptor 3 Homo sapiens 8.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271515 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271515&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752080 378153343 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655356 OC(=O)C1(Cn2c(=O)[nH]\c(=N/c3ccc(Oc4cccc(F)n4)cc3)n(Cc3ccc(Cl)cc3)c2=O)CC1 InChI=1S/C26H21ClFN5O5/c27-17-6-4-16(5-7-17)14-32-23(31-24(36)33(25(32)37)15-26(12-13-26)22(34)35)29-18-8-10-19(11-9-18)38-21-3-1-2-20(28)30-21/h1-11H,12-15H2,(H,34,35)(H,29,31,36) NIVAFFJLOOMGLF-UHFFFAOYSA-N 271516 US10065941, Compound I-017::US9732060, Compound I-017 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271516 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271516&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752077 378153344 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655357 OC(=O)C1(Cn2c(=O)[nH]\c(=N/c3ccc(Oc4ccc(F)cn4)cc3)n(Cc3ccc(Cl)cc3)c2=O)CC1 InChI=1S/C26H21ClFN5O5/c27-17-3-1-16(2-4-17)14-32-23(31-24(36)33(25(32)37)15-26(11-12-26)22(34)35)30-19-6-8-20(9-7-19)38-21-10-5-18(28)13-29-21/h1-10,13H,11-12,14-15H2,(H,34,35)(H,30,31,36) XTVJZQVEKPCHOX-UHFFFAOYSA-N 271517 US10065941, Compound I-018::US9732060, Compound I-018 P2X purinoceptor 3 Homo sapiens 12.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271517 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271517&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752087 378153345 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655358 OC(=O)[C@H]1C[C@@H](C1)n1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(F)cn3)cc2)n(Cc2ccc(Cl)cc2)c1=O 271518 US10065941, Compound I-019::US9732060, Compound I-019 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271518 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271518&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752079 378153346 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655359 OC(=O)[C@H]1C[C@H](C1)n1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(F)cn3)cc2)n(Cc2ccc(Cl)cc2)c1=O 271519 US10065941, Compound I-020::US9732060, Compound I-020 P2X purinoceptor 3 Homo sapiens 9.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271519 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271519&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752079 378153347 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655360 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(OC(F)F)cn3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C28H26ClF2N5O6/c1-28(2,23(37)40-3)16-36-26(38)34-25(35(27(36)39)15-17-4-6-18(29)7-5-17)33-19-8-10-20(11-9-19)41-22-13-12-21(14-32-22)42-24(30)31/h4-14,24H,15-16H2,1-3H3,(H,33,34,38) JGPMZUHKUJEZCW-UHFFFAOYSA-N 271520 US10065941, Compound I-021::US9732060, Compound I-021 P2X purinoceptor 3 Homo sapiens 25.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271520 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271520&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752096 378153348 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655361 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(OC(F)F)cn3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271521 US10065941, Compound I-022::US9732060, Compound I-022 P2X purinoceptor 3 Homo sapiens 4.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271521 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271521&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121285500 378153349 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655362 CC(C)(Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(OC(F)F)cn3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O InChI=1S/C27H24ClF2N5O6/c1-27(2,22(36)37)15-35-25(38)33-24(34(26(35)39)14-16-3-5-17(28)6-4-16)32-18-7-9-19(10-8-18)40-21-12-11-20(13-31-21)41-23(29)30/h3-13,23H,14-15H2,1-2H3,(H,36,37)(H,32,33,38) JSNOAMVAKYGROY-UHFFFAOYSA-N 271522 US10065941, Compound I-023::US9732060, Compound I-023 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271522 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271522&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295398 378153350 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655363 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ncccc3F)cc2)n(Cc2ccc(F)cc2F)c1=O 271523 US10065941, Compound I-024::US9732060, Compound I-024 P2X purinoceptor 3 Homo sapiens 34.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271523 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271523&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752097 378153351 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655364 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(F)cn3)cc2)n(Cc2ccc(F)cc2F)c1=O 271524 US10065941, Compound I-025::US9732060, Compound I-025 P2X purinoceptor 3 Homo sapiens 23.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271524 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271524&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752089 378153352 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655365 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(F)n3)cc2)n(Cc2ccc(F)cc2F)c1=O 271525 US10065941, Compound I-026::US9732060, Compound I-026 P2X purinoceptor 3 Homo sapiens 17.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271525 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271525&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752250 378153353 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655366 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ncccc3F)cc2)n(Cc2ccc(F)cc2F)c1=O)C(O)=O 271526 US10065941, Compound I-027::US9732060, Compound I-027 P2X purinoceptor 3 Homo sapiens 39.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271526 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271526&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752253 378153354 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655367 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(F)cn3)cc2)n(Cc2ccc(F)cc2F)c1=O)C(O)=O 271527 US10065941, Compound I-028::US9732060, Compound I-028 P2X purinoceptor 3 Homo sapiens 20.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271527 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271527&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752249 378153355 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655368 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(F)n3)cc2)n(Cc2ccc(F)cc2F)c1=O)C(O)=O 271528 US10065941, Compound I-029::US9732060, Compound I-029 P2X purinoceptor 3 Homo sapiens 14.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271528 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271528&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752254 378153356 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655369 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ncccc3C(F)(F)F)cc2)n(Cc2ccc(Cl)cc2)c1=O 271529 US10065941, Compound I-030::US9732060, Compound I-030 P2X purinoceptor 3 Homo sapiens 176 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271529 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271529&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752255 378153357 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655370 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ncccc3C(F)(F)F)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C28H25ClF3N5O5/c1-27(2,23(38)41-3)16-37-25(39)35-24(36(26(37)40)15-17-6-8-18(29)9-7-17)34-19-10-12-20(13-11-19)42-22-21(28(30,31)32)5-4-14-33-22/h4-14H,15-16H2,1-3H3,(H,34,35,39) DNXMRCVOSPXHJA-UHFFFAOYSA-N 271530 US10065941, Compound I-031::US9732060, Compound I-031 P2X purinoceptor 3 Homo sapiens 199 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271530 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271530&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295399 378153358 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655371 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ncccc3C(F)(F)F)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271531 US10065941, Compound I-032::US9732060, Compound I-032 P2X purinoceptor 3 Homo sapiens 11.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271531 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271531&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752261 378153359 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655372 CC(C)(Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ncccc3C(F)(F)F)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O InChI=1S/C27H23ClF3N5O5/c1-26(2,22(37)38)15-36-24(39)34-23(35(25(36)40)14-16-5-7-17(28)8-6-16)33-18-9-11-19(12-10-18)41-21-20(27(29,30)31)4-3-13-32-21/h3-13H,14-15H2,1-2H3,(H,37,38)(H,33,34,39) BTJJWEQWDHOPAU-UHFFFAOYSA-N 271532 US10065941, Compound I-033::US9732060, Compound I-033 P2X purinoceptor 3 Homo sapiens 23.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271532 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271532&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295400 378153360 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655373 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(cn3)C(F)(F)F)cc2)n(Cc2ccc(C)cc2)c1=O 271533 US10065941, Compound I-034::US9732060, Compound I-034 P2X purinoceptor 3 Homo sapiens 9.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271533&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752262 378153361 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655374 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(n3)C(F)(F)F)cc2)n(Cc2ccc(C)cc2)c1=O 271534 US10065941, Compound I-035::US9732060, Compound I-035 P2X purinoceptor 3 Homo sapiens 12.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271534 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271534&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752282 378153362 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655375 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(F)cn3)cc2)n(Cc2ccc(C)cc2)c1=O 271535 US10065941, Compound I-036::US10065941, Compound I-129::US9732060, Compound I-129 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271535 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271535&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752331 378153363 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655376 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(F)cn3)cc2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C28H28FN5O5/c1-18-5-7-19(8-6-18)16-33-25(32-26(36)34(27(33)37)17-28(2,3)24(35)38-4)31-21-10-12-22(13-11-21)39-23-14-9-20(29)15-30-23/h5-15H,16-17H2,1-4H3,(H,31,32,36) UVJOKJWCJVBVAH-UHFFFAOYSA-N 271536 US10065941, Compound I-037::US9732060, Compound I-037 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271536 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271536&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752333 378153364 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655377 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(cn3)C(F)(F)F)cc2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 271537 US10065941, Compound I-038::US9732060, Compound I-038 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271537 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271537&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752332 378153365 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655378 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(n3)C(F)(F)F)cc2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 271538 US10065941, Compound I-039::US9732060, Compound I-039 P2X purinoceptor 3 Homo sapiens 8.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271538 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271538&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752334 378153366 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655379 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(F)cn3)cc2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 271539 US10065941, Compound I-040::US10065941, Compound I-130::US9732060, Compound I-130 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271539 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271539&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752335 378153367 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655380 Cc1ccc(Cn2c(=O)n(CC(C)(C)C(O)=O)c(=O)[nH]\c2=N/c2ccc(Oc3ccc(F)cn3)cc2)cc1 InChI=1S/C27H26FN5O5/c1-17-4-6-18(7-5-17)15-32-24(31-25(36)33(26(32)37)16-27(2,3)23(34)35)30-20-9-11-21(12-10-20)38-22-13-8-19(28)14-29-22/h4-14H,15-16H2,1-3H3,(H,34,35)(H,30,31,36) GXGCGKGZBZYUGT-UHFFFAOYSA-N 271540 US10065941, Compound I-041::US9732060, Compound I-041 P2X purinoceptor 3 Homo sapiens 9.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271540 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271540&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752305 378153368 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655381 OCC1(Cn2c(=O)[nH]\c(=N/c3ccc(Oc4cccc(F)n4)cc3)n(Cc3ccc(Cl)cc3)c2=O)COC1 InChI=1S/C26H23ClFN5O5/c27-18-6-4-17(5-7-18)12-32-23(31-24(35)33(25(32)36)13-26(14-34)15-37-16-26)29-19-8-10-20(11-9-19)38-22-3-1-2-21(28)30-22/h1-11,34H,12-16H2,(H,29,31,35) VTTBVJRGDXWJQC-UHFFFAOYSA-N 271541 US10065941, Compound I-042::US9732060, Compound I-042 P2X purinoceptor 3 Homo sapiens 4.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271541 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271541&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 86567205 378153369 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655382 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ncccc3OC(F)F)cc2)n(Cc2ccc(Cl)cc2)c1=O 271542 US10065941, Compound I-043::US9732060, Compound I-043 P2X purinoceptor 3 Homo sapiens 117 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271542 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271542&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295401 378153370 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655383 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ncccc3OC(F)F)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271543 US10065941, Compound I-044::US9732060, Compound I-044 P2X purinoceptor 3 Homo sapiens 26.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271543 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271543&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295402 378153371 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655384 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ncccc3C#N)cc2)n(Cc2ccc(Cl)cc2)c1=O 271544 US10065941, Compound I-045::US9732060, Compound I-045 P2X purinoceptor 3 Homo sapiens 19.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271544 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271544&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752324 378153372 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655385 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ncccc3C#N)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C28H25ClN6O5/c1-28(2,24(36)39-3)17-35-26(37)33-25(34(27(35)38)16-18-6-8-20(29)9-7-18)32-21-10-12-22(13-11-21)40-23-19(15-30)5-4-14-31-23/h4-14H,16-17H2,1-3H3,(H,32,33,37) KHGVWZBOVSZOOI-UHFFFAOYSA-N 271545 US10065941, Compound I-046::US9732060, Compound I-046 P2X purinoceptor 3 Homo sapiens 19.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271545 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271545&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295403 378153373 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655386 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ncccc3C#N)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271546 US10065941, Compound I-047::US9732060, Compound I-047 P2X purinoceptor 3 Homo sapiens 22.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271546 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271546&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752316 378153374 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655387 CC(C)(Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ncccc3C#N)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O InChI=1S/C27H23ClN6O5/c1-27(2,23(35)36)16-34-25(37)32-24(33(26(34)38)15-17-5-7-19(28)8-6-17)31-20-9-11-21(12-10-20)39-22-18(14-29)4-3-13-30-22/h3-13H,15-16H2,1-2H3,(H,35,36)(H,31,32,37) SSHDQQIDZMBXEA-UHFFFAOYSA-N 271547 US10065941, Compound I-048::US9732060, Compound I-048 P2X purinoceptor 3 Homo sapiens 30.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271547 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271547&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295404 378153375 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655388 OC(=O)C1(Cn2c(=O)[nH]\c(=N/c3ccc(Oc4cccc(F)n4)cc3)n(Cc3ccc(Cl)cc3)c2=O)COC1 InChI=1S/C26H21ClFN5O6/c27-17-6-4-16(5-7-17)12-32-23(31-24(36)33(25(32)37)13-26(22(34)35)14-38-15-26)29-18-8-10-19(11-9-18)39-21-3-1-2-20(28)30-21/h1-11H,12-15H2,(H,34,35)(H,29,31,36) OFCLQVOIAILOKU-UHFFFAOYSA-N 271548 US10065941, Compound I-049::US9732060, Compound I-049 P2X purinoceptor 3 Homo sapiens 15.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271548 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271548&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752309 378153376 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655389 OC(=O)C1(Cn2c(=O)[nH]\c(=N/c3ccc(Oc4ncccc4F)cc3)n(Cc3ccc(Cl)cc3)c2=O)COC1 InChI=1S/C26H21ClFN5O6/c27-17-5-3-16(4-6-17)12-32-23(31-24(36)33(25(32)37)13-26(22(34)35)14-38-15-26)30-18-7-9-19(10-8-18)39-21-20(28)2-1-11-29-21/h1-11H,12-15H2,(H,34,35)(H,30,31,36) MNQIYNSUTGJBAX-UHFFFAOYSA-N 271549 US10065941, Compound I-050::US9732060, Compound I-050 P2X purinoceptor 3 Homo sapiens 28.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271549 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271549&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752311 378153377 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655390 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(C)cn3)cc2)n(Cc2ccc(Cl)cc2)c1=O 271550 US10065941, Compound I-051::US9732060, Compound I-051 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271550 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271550&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752274 378153378 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655391 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ncccc3F)cc2)n(Cc2ccc(C)cc2)c1=O 271551 US10065941, Compound I-052::US9732060, Compound I-052 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271551 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271551&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752263 378153379 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655392 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(F)n3)cc2)n(Cc2ccc(C)cc2)c1=O 271552 US10065941, Compound I-053::US9732060, Compound I-053 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271552 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271552&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295405 378153380 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655393 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(C)cn3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271553 US10065941, Compound I-054::US9732060, Compound I-054 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271553 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271553&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752283 378153381 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655394 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(C)cn3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C28H28ClN5O5/c1-18-5-14-23(30-15-18)39-22-12-10-21(11-13-22)31-25-32-26(36)34(17-28(2,3)24(35)38-4)27(37)33(25)16-19-6-8-20(29)9-7-19/h5-15H,16-17H2,1-4H3,(H,31,32,36) AALPGRJMGHQTMB-UHFFFAOYSA-N 271554 US10065941, Compound I-055::US9732060, Compound I-055 P2X purinoceptor 3 Homo sapiens 9.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271554 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271554&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752284 378153382 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655395 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ncccc3F)cc2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 271555 US10065941, Compound I-056::US9732060, Compound I-056 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271555 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271555&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752329 378153383 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655396 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(F)n3)cc2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 271556 US10065941, Compound I-057::US9732060, Compound I-057 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271556 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271556&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752319 378153384 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655397 Cc1ccc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n2Cc2ccc(Cl)cc2)nc1 InChI=1S/C27H26ClN5O5/c1-17-4-13-22(29-14-17)38-21-11-9-20(10-12-21)30-24-31-25(36)33(16-27(2,3)23(34)35)26(37)32(24)15-18-5-7-19(28)8-6-18/h4-14H,15-16H2,1-3H3,(H,34,35)(H,30,31,36) VKWDANGMJGKQJB-UHFFFAOYSA-N 271557 US10065941, Compound I-058::US9732060, Compound I-058 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271557 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271557&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752330 378153385 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655398 OC(=O)C1(Cn2c(=O)[nH]\c(=N/c3ccc(Oc4ccc(F)cn4)cc3)n(Cc3ccc(Cl)cc3)c2=O)COC1 InChI=1S/C26H21ClFN5O6/c27-17-3-1-16(2-4-17)12-32-23(31-24(36)33(25(32)37)13-26(22(34)35)14-38-15-26)30-19-6-8-20(9-7-19)39-21-10-5-18(28)11-29-21/h1-11H,12-15H2,(H,34,35)(H,30,31,36) IVCYQHDQRAIRRG-UHFFFAOYSA-N 271558 US10065941, Compound I-059::US9732060, Compound I-059 P2X purinoceptor 3 Homo sapiens 16.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271558 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271558&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752320 378153386 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655399 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cc(Cl)ccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O 271559 US10065941, Compound I-060::US9732060, Compound I-060 P2X purinoceptor 3 Homo sapiens 24.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271559 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271559&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295406 378153387 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655400 CCOC(=O)[C@H]1C[C@@H](C1)n1c(=O)[nH]\c(=N/c2ccc(Oc3ncccc3F)cc2)n(Cc2ccc(Cl)cc2)c1=O 271560 US10065941, Compound I-061::US9732060, Compound I-061 P2X purinoceptor 3 Homo sapiens 62.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271560 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271560&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752219 378153388 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655401 CCOC(=O)[C@H]1C[C@H](C1)n1c(=O)[nH]\c(=N/c2ccc(Oc3ncccc3F)cc2)n(Cc2ccc(Cl)cc2)c1=O 271561 US10065941, Compound I-062::US9732060, Compound I-062 P2X purinoceptor 3 Homo sapiens 31.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271561 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271561&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752219 378153389 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655402 OC(=O)[C@H]1C[C@@H](C1)n1c(=O)[nH]\c(=N/c2ccc(Oc3ncccc3F)cc2)n(Cc2ccc(Cl)cc2)c1=O 271562 US10065941, Compound I-063::US9732060, Compound I-063 P2X purinoceptor 3 Homo sapiens 9.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271562 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271562&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295407 378153390 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655403 OC(=O)[C@H]1C[C@H](C1)n1c(=O)[nH]\c(=N/c2ccc(Oc3ncccc3F)cc2)n(Cc2ccc(Cl)cc2)c1=O 271563 US10065941, Compound I-064::US9732060, Compound I-064 P2X purinoceptor 3 Homo sapiens 10.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271563 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271563&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295407 378153391 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655404 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cc(Cl)ccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271564 US10065941, Compound I-065::US9732060, Compound I-065 P2X purinoceptor 3 Homo sapiens 8.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271564 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271564&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295408 378153392 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655405 CCOC(=O)C1(Cn2c(=O)[nH]\c(=N/c3ccc(Oc4ncccc4F)cc3)n(Cc3ccc(Cl)cc3)c2=O)CC1 InChI=1S/C28H25ClFN5O5/c1-2-39-24(36)28(13-14-28)17-35-26(37)33-25(34(27(35)38)16-18-5-7-19(29)8-6-18)32-20-9-11-21(12-10-20)40-23-22(30)4-3-15-31-23/h3-12,15H,2,13-14,16-17H2,1H3,(H,32,33,37) LPJSFDIHWQRGJR-UHFFFAOYSA-N 271565 US10065941, Compound I-066::US9732060, Compound I-066 P2X purinoceptor 3 Homo sapiens 15.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271565 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271565&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752185 378153393 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655406 OC(=O)C1(Cn2c(=O)[nH]\c(=N/c3ccc(Oc4ncccc4F)cc3)n(Cc3ccc(Cl)cc3)c2=O)CC1 InChI=1S/C26H21ClFN5O5/c27-17-5-3-16(4-6-17)14-32-23(31-24(36)33(25(32)37)15-26(11-12-26)22(34)35)30-18-7-9-19(10-8-18)38-21-20(28)2-1-13-29-21/h1-10,13H,11-12,14-15H2,(H,34,35)(H,30,31,36) IIGGPTNKMMORJQ-UHFFFAOYSA-N 271566 US10065941, Compound I-067::US9732060, Compound I-067 P2X purinoceptor 3 Homo sapiens 11.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271566 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271566&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752231 378153394 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655407 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cc(F)ccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O 271567 US10065941, Compound I-068::US9732060, Compound I-068 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271567 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271567&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752235 378153395 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655408 COc1ccnc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n2Cc2ccc(Cl)cc2)c1 271568 US10065941, Compound I-069::US9732060, Compound I-069 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271568 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271568&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752209 378153396 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655409 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cc(F)ccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271569 US10065941, Compound I-070::US9732060, Compound I-070 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271569 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271569&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752201 378153397 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655792 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271964 US10065941, Compound I-212::US9732060, Compound I-212 P2X purinoceptor 3 Homo sapiens 10.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271964 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271964&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752207 378153789 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655793 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)c(C)c2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 271966 US10065941, Compound I-213::US9732060, Compound I-213 P2X purinoceptor 3 Homo sapiens 12.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271966 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271966&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295437 378153791 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655794 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(Cc2ccc(CF)cc2)c1=O)C(O)=O 271968 US10065941, Compound I-214::US9732060, Compound I-214 P2X purinoceptor 3 Homo sapiens 11.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271968 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271968&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752226 378153793 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655795 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ncccc3F)cc2)n(Cc2ccc(CF)cc2)c1=O)C(O)=O 271970 US10065941, Compound I-215::US9732060, Compound I-215 P2X purinoceptor 3 Homo sapiens 16.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271970 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271970&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752373 378153795 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655796 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(F)cn3)cc2)n(Cc2ccc(CF)cc2)c1=O)C(O)=O 271972 US10065941, Compound I-216::US9732060, Compound I-216 P2X purinoceptor 3 Homo sapiens 17.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271972 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271972&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752374 378153797 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655797 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(F)n3)cc2)n(Cc2ccc(CF)cc2)c1=O)C(O)=O 271974 US10065941, Compound I-217::US9732060, Compound I-217 P2X purinoceptor 3 Homo sapiens 11.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271974 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271974&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752361 378153799 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655798 COc1cccc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n2Cc2ccc(C)cc2)n1 271976 US10065941, Compound I-218::US9732060, Compound I-218 P2X purinoceptor 3 Homo sapiens 10.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271976 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271976&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295438 378153801 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655799 Cc1cc(ccc1Oc1ccccn1)\N=c1/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C27H26ClN5O5/c1-17-14-20(11-12-21(17)38-22-6-4-5-13-29-22)30-24-31-25(36)33(16-27(2,3)23(34)35)26(37)32(24)15-18-7-9-19(28)10-8-18/h4-14H,15-16H2,1-3H3,(H,34,35)(H,30,31,36) UEISQYYFQGQLOA-UHFFFAOYSA-N 271978 US10065941, Compound I-219::US9732060, Compound I-219 P2X purinoceptor 3 Homo sapiens 12.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271978 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271978&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752362 378153803 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655800 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271980 US10065941, Compound I-220::US9732060, Compound I-220 P2X purinoceptor 3 Homo sapiens 10.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271980 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271980&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752120 378153805 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655801 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(OC)n3)cc2)n(Cc2ccc(C)cc2)c1=O 271982 US10065941, Compound I-221::US9732060, Compound I-221 P2X purinoceptor 3 Homo sapiens 11.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271982 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271982&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752118 378153807 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655802 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(OC)cn3)cc2)n(Cc2ccc(C)cc2)c1=O 271984 US10065941, Compound I-222::US9732060, Compound I-222 P2X purinoceptor 3 Homo sapiens 4.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271984 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271984&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752119 378153809 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655803 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O 271986 US10065941, Compound I-223::US9732060, Compound I-223 P2X purinoceptor 3 Homo sapiens 11.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271986 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271986&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752129 378153811 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655804 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)c(C)c2)n(Cc2ccc(C)cc2)c1=O 271988 US10065941, Compound I-224::US9732060, Compound I-224 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271988 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271988&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752121 378153813 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655805 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C28H28ClN5O5/c1-18-15-21(12-13-22(18)39-23-7-5-6-14-30-23)31-25-32-26(36)34(17-28(2,3)24(35)38-4)27(37)33(25)16-19-8-10-20(29)11-9-19/h5-15H,16-17H2,1-4H3,(H,31,32,36) BFZGLKHEKBTCIN-UHFFFAOYSA-N 271990 US10065941, Compound I-225::US9732060, Compound I-225 P2X purinoceptor 3 Homo sapiens 14.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271990 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271990&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752193 378153815 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655806 COC(=O)[C@H](C)[C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O 271992 US10065941, Compound I-226::US9732060, Compound I-226 P2X purinoceptor 3 Homo sapiens 38.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271992 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271992&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752238 378153817 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655807 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C27H25ClFN5O5/c1-27(2,23(35)38-3)16-34-25(36)32-24(33(26(34)37)15-17-7-9-18(28)10-8-17)31-19-11-12-21(20(29)14-19)39-22-6-4-5-13-30-22/h4-14H,15-16H2,1-3H3,(H,31,32,36) ABPXHJZMOOCTEP-UHFFFAOYSA-N 271994 US10065941, Compound I-227::US9732060, Compound I-227 P2X purinoceptor 3 Homo sapiens 31.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271994 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271994&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752176 378153819 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655808 COC(=O)[C@H](C)[C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O 271996 US10065941, Compound I-228::US9732060, Compound I-228 P2X purinoceptor 3 Homo sapiens 21.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271996 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271996&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295440 378153821 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655809 COc1ccc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n2Cc2ccc(C)cc2)nc1 271998 US10065941, Compound I-229::US9732060, Compound I-229 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271998 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271998&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295441 378153823 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655810 CC(C)(Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O InChI=1S/C26H23ClFN5O5/c1-26(2,22(34)35)15-33-24(36)31-23(32(25(33)37)14-16-6-8-17(27)9-7-16)30-18-10-11-20(19(28)13-18)38-21-5-3-4-12-29-21/h3-13H,14-15H2,1-2H3,(H,34,35)(H,30,31,36) GQGUDZAMEOXEAU-UHFFFAOYSA-N 272000 US10065941, Compound I-230::US9732060, Compound I-230 P2X purinoceptor 3 Homo sapiens 11.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272000 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272000&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752173 378153825 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655811 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 272002 US10065941, Compound I-231::US9732060, Compound I-231 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272002 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272002&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752199 378153827 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655812 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(CF)cn3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 272004 US10065941, Compound I-232::US9732060, Compound I-232 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272004 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272004&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295442 378153829 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655813 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(CF)nc3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 272006 US10065941, Compound I-233::US9732060, Compound I-233 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272006 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272006&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295443 378153831 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655814 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(F)n3)cc2)n(CC2CCC3(CC3)CC2)c1=O)C(O)=O 272008 US10065941, Compound I-234::US9732060, Compound I-234 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272008 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272008&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752229 378153833 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655815 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(F)cn3)cc2)n(CC2CCC3(CC3)CC2)c1=O)C(O)=O 272010 US10065941, Compound I-235::US9732060, Compound I-235 P2X purinoceptor 3 Homo sapiens 9.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272010 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272010&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752236 378153835 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655816 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(F)n3)cc2)n(CC2CCC3(CC3)CC2)c1=O 272012 US10065941, Compound I-236::US9732060, Compound I-236 P2X purinoceptor 3 Homo sapiens 16.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272012 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272012&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295444 378153837 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655817 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(F)cn3)cc2)n(CC2CCC3(CC3)CC2)c1=O 272014 US10065941, Compound I-237::US9732060, Compound I-237 P2X purinoceptor 3 Homo sapiens 14.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272014 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272014&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752237 378153839 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655818 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(CF)cn3)cc2)n(Cc2ccc(Cl)cc2)c1=O 272016 US10065941, Compound I-238::US9732060, Compound I-238 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272016 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272016&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295446 378153841 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655819 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(CF)nc3)cc2)n(Cc2ccc(Cl)cc2)c1=O 272018 US10065941, Compound I-239::US9732060, Compound I-239 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272018 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272018&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295445 378153843 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655820 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cc(CO)ccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 272019 US10065941, Compound I-240::US9732060, Compound I-240 P2X purinoceptor 3 Homo sapiens 22.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272019 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272019&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295448 378153844 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655821 COCc1ccc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n2Cc2ccc(Cl)cc2)nc1 272020 US10065941, Compound I-241::US9732060, Compound I-241 P2X purinoceptor 3 Homo sapiens 8.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272020 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272020&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295447 378153845 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655822 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(CF)cn3)cc2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 272021 US10065941, Compound I-242::US9732060, Compound I-242 P2X purinoceptor 3 Homo sapiens 8.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272021 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272021&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752296 378153846 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655823 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)c(Cl)c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 272022 US10065941, Compound I-243::US9732060, Compound I-243 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272022 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272022&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752297 378153847 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655824 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)c(F)c2)n(C[C@H]2CC[C@H](C)CC2)c1=O)C(O)=O 272023 US10065941, Compound I-244::US9732060, Compound I-244 P2X purinoceptor 3 Homo sapiens 8.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272023 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272023&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752292 378153848 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655825 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(CO)n3)cc2)n(Cc2ccc(Cl)cc2)c1=O 272024 US10065941, Compound I-245::US9732060, Compound I-245 P2X purinoceptor 3 Homo sapiens 14.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272024 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272024&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295449 378153849 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655826 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(CO)n3)cc2)n(Cc2ccc(C)cc2)c1=O 272025 US10065941, Compound I-246::US9732060, Compound I-246 P2X purinoceptor 3 Homo sapiens 14.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272025 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272025&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752355 378153850 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655827 COCc1ccc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(C[C@H](C)C(=O)OC)c(=O)n2Cc2ccc(Cl)cc2)nc1 272026 US10065941, Compound I-247::US9732060, Compound I-247 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272026 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272026&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295450 378153851 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655828 COCc1ccc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(C[C@H](C)C(=O)OC)c(=O)n2Cc2ccc(C)cc2)nc1 272027 US10065941, Compound I-248::US9732060, Compound I-248 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272027 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272027&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752375 378153852 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655829 COCc1cccc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(C[C@H](C)C(=O)OC)c(=O)n2Cc2ccc(Cl)cc2)n1 272028 US10065941, Compound I-249::US9732060, Compound I-249 P2X purinoceptor 3 Homo sapiens 36.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272028 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272028&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752357 378153853 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655830 COCc1cccc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(C[C@H](C)C(=O)OC)c(=O)n2Cc2ccc(C)cc2)n1 272029 US10065941, Compound I-250::US9732060, Compound I-250 P2X purinoceptor 3 Homo sapiens 31.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272029 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272029&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295452 378153854 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655831 CCc1ccc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(C[C@H](C)C(=O)OC)c(=O)n2Cc2ccc(Cl)cc2)nc1 272030 US10065941, Compound I-251::US9732060, Compound I-251 P2X purinoceptor 3 Homo sapiens 8.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272030 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272030&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295451 378153855 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655832 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)c(Cl)c2)n(Cc2ccc(Cl)cc2)c1=O 272031 US10065941, Compound I-252::US9732060, Compound I-252 P2X purinoceptor 3 Homo sapiens 14.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272031 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272031&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752123 378153856 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655833 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)c(F)c2)n(C[C@H]2CC[C@H](C)CC2)c1=O 334772 US9732060, Compound I-253 P2X purinoceptor 3 Homo sapiens 9.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=334772 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=334772&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752122 384986932 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655834 COCc1ccc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n2Cc2ccc(C)cc2)nc1 272033 US10065941, Compound I-254::US9732060, Compound I-254 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272033 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272033&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752124 378153857 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655835 COCc1cccc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n2Cc2ccc(Cl)cc2)n1 272034 US10065941, Compound I-255::US9732060, Compound I-255 P2X purinoceptor 3 Homo sapiens 18.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272034 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272034&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752203 378153858 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655836 COCc1cccc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n2Cc2ccc(C)cc2)n1 272035 US10065941, Compound I-256::US9732060, Compound I-256 P2X purinoceptor 3 Homo sapiens 29.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272035 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272035&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295454 378153859 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655837 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(CO)n3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 272036 US10065941, Compound I-257::US9732060, Compound I-257 P2X purinoceptor 3 Homo sapiens 16.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272036 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272036&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752239 378153860 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655838 CCc1ccc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n2Cc2ccc(Cl)cc2)nc1 272037 US10065941, Compound I-258::US9732060, Compound I-258 P2X purinoceptor 3 Homo sapiens 4.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272037 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272037&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295453 378153861 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655839 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(cn3)C(C)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 272038 US10065941, Compound I-259::US9732060, Compound I-259 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272038 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272038&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295455 378153862 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655840 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(cn3)C(C)=O)cc2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 272039 US10065941, Compound I-260::US9732060, Compound I-260 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272039 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272039&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752367 378153863 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655841 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(CF)n3)cc2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 272040 US10065941, Compound I-261::US9732060, Compound I-261 P2X purinoceptor 3 Homo sapiens 8.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272040 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272040&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752358 378153864 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655842 CC(O)c1ccc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n2Cc2ccc(C)cc2)nc1 272041 US10065941, Compound I-262::US9732060, Compound I-262 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272041 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272041&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295456 378153865 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655843 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(CC2CC3(CCC3)C2)c1=O)C(O)=O 272042 US10065941, Compound I-263::US9732060, Compound I-263 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272042 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272042&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295457 378153866 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655844 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(F)cn3)cc2)n(CC2CC3(CCC3)C2)c1=O)C(O)=O 272043 US10065941, Compound I-264::US9732060, Compound I-264 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272043 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272043&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752377 378153867 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655845 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(CI)n3)cc2)n(Cc2ccc(C)cc2)c1=O 272044 US10065941, Compound I-265::US9732060, Compound I-265 P2X purinoceptor 3 Homo sapiens 10.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272044 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272044&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752225 378153868 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655846 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(CF)n3)cc2)n(Cc2ccc(C)cc2)c1=O 272045 US10065941, Compound I-266::US9732060, Compound I-266 P2X purinoceptor 3 Homo sapiens 8.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272045 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272045&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752211 378153869 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655847 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(cn3)C(C)=O)cc2)n(Cc2ccc(C)cc2)c1=O 272046 US10065941, Compound I-267::US9732060, Compound I-267 P2X purinoceptor 3 Homo sapiens 3.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272046 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272046&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752232 378153870 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655848 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(CC2CC3(CCC3)C2)c1=O 272047 US10065941, Compound I-268::US9732060, Compound I-268 P2X purinoceptor 3 Homo sapiens 3.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272047 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272047&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752174 378153871 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655849 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(F)cn3)cc2)n(CC2CC3(CCC3)C2)c1=O 272048 US10065941, Compound I-269::US9732060, Compound I-269 P2X purinoceptor 3 Homo sapiens 4.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272048 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272048&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752233 378153872 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655850 CCc1ccc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(C[C@H](C)C(=O)OC)c(=O)n2Cc2ccc(C)cc2)nc1 272049 US10065941, Compound I-270::US9732060, Compound I-270 P2X purinoceptor 3 Homo sapiens 4.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272049 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272049&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752125 378153873 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655851 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(Cc2ccc(Cl)s2)c1=O 272050 US10065941, Compound I-271::US9732060, Compound I-271 P2X purinoceptor 3 Homo sapiens 10.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272050 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272050&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752126 378153874 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655852 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(F)cn3)cc2)n(Cc2ccc(Cl)s2)c1=O 272051 US10065941, Compound I-272::US9732060, Compound I-272 P2X purinoceptor 3 Homo sapiens 8.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272051 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272051&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752127 378153875 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655853 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(Cc2ccc(Cl)s2)c1=O)C(O)=O 272052 US10065941, Compound I-273::US9732060, Compound I-273 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272052 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272052&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752131 378153876 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655410 COC(=O)[C@H](C)[C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(OC(F)F)cn3)cc2)n(Cc2ccc(Cl)cc2)c1=O 271570 US10065941, Compound I-071::US9732060, Compound I-071 P2X purinoceptor 3 Homo sapiens 38.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271570 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271570&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295409 378153398 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655411 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(OC(F)F)cn3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271571 US10065941, Compound I-072::US9732060, Compound I-072 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271571 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271571&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295410 378153399 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655412 COC(=O)[C@H](C)[C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(C)cn3)cc2)n(Cc2ccc(Cl)cc2)c1=O 271572 US10065941, Compound I-073::US9732060, Compound I-073 P2X purinoceptor 3 Homo sapiens 15.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271572 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271572&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752227 378153400 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655413 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(C)cn3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271573 US10065941, Compound I-074::US9732060, Compound I-074 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271573 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271573&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752178 378153401 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655414 COC(=O)[C@H](C)[C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3cc(ccn3)C#N)cc2)n(Cc2ccc(Cl)cc2)c1=O 271574 US10065941, Compound I-075::US9732060, Compound I-075 P2X purinoceptor 3 Homo sapiens 21.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271574 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271574&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752217 378153402 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655415 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cc(C)ccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O 271575 US10065941, Compound I-076::US9732060, Compound I-076 P2X purinoceptor 3 Homo sapiens 22.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271575 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271575&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295411 378153403 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655416 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ncccc3C)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271576 US10065941, Compound I-077::US9732060, Compound I-077 P2X purinoceptor 3 Homo sapiens 10.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271576 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271576&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295412 378153404 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655417 Cc1cccnc1Oc1ccc(cc1)\N=c1/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C27H26ClN5O5/c1-17-5-4-14-29-22(17)38-21-12-10-20(11-13-21)30-24-31-25(36)33(16-27(2,3)23(34)35)26(37)32(24)15-18-6-8-19(28)9-7-18/h4-14H,15-16H2,1-3H3,(H,34,35)(H,30,31,36) DITAJEZEBFWEFI-UHFFFAOYSA-N 271577 US10065941, Compound I-078::US9732060, Compound I-078 P2X purinoceptor 3 Homo sapiens 19.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271577 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271577&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752075 378153405 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655418 COc1ccc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n2Cc2ccc(Cl)cc2)nc1 271578 US10065941, Compound I-079::US9732060, Compound I-079 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271578 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271578&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752076 378153406 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655419 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cc(C)ccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271579 US10065941, Compound I-080::US9732060, Compound I-080 P2X purinoceptor 3 Homo sapiens 10.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271579 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271579&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295414 378153407 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655420 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cc(Cl)ccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C27H25Cl2N5O5/c1-27(2,23(35)38-3)16-34-25(36)32-24(33(26(34)37)15-17-4-6-18(28)7-5-17)31-20-8-10-21(11-9-20)39-22-14-19(29)12-13-30-22/h4-14H,15-16H2,1-3H3,(H,31,32,36) HFEJVCAJTAREHJ-UHFFFAOYSA-N 271580 US10065941, Compound I-081::US9732060, Compound I-081 P2X purinoceptor 3 Homo sapiens 38.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271580 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271580&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295413 378153408 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655421 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cc(ccn3)C(F)(F)F)cc2)n(Cc2ccc(Cl)cc2)c1=O 271581 US10065941, Compound I-082::US9732060, Compound I-082 P2X purinoceptor 3 Homo sapiens 112 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271581 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271581&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752323 378153409 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655422 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(CO)cn3)cc2)n(Cc2ccc(Cl)cc2)c1=O 271582 US10065941, Compound I-083::US9732060, Compound I-083 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271582 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271582&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295416 378153410 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655423 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(CO)cn3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271583 US10065941, Compound I-084::US9732060, Compound I-084 P2X purinoceptor 3 Homo sapiens 8.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271583 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271583&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295415 378153411 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655424 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cc(ccn3)C(F)(F)F)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C28H25ClF3N5O5/c1-27(2,23(38)41-3)16-37-25(39)35-24(36(26(37)40)15-17-4-6-19(29)7-5-17)34-20-8-10-21(11-9-20)42-22-14-18(12-13-33-22)28(30,31)32/h4-14H,15-16H2,1-3H3,(H,34,35,39) XFDSYLNTCQUHNU-UHFFFAOYSA-N 271584 US10065941, Compound I-085::US9732060, Compound I-085 P2X purinoceptor 3 Homo sapiens 225 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271584 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271584&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752340 378153412 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655425 CC(C)(Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cc(Cl)ccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O InChI=1S/C26H23Cl2N5O5/c1-26(2,22(34)35)15-33-24(36)31-23(32(25(33)37)14-16-3-5-17(27)6-4-16)30-19-7-9-20(10-8-19)38-21-13-18(28)11-12-29-21/h3-13H,14-15H2,1-2H3,(H,34,35)(H,30,31,36) ZBNIESORYSQSQU-UHFFFAOYSA-N 271585 US10065941, Compound I-086::US9732060, Compound I-086 P2X purinoceptor 3 Homo sapiens 33.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271585 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271585&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295417 378153413 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655426 COC(=O)[C@H](C)[C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3cc(Cl)ccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O 271586 US10065941, Compound I-087::US9732060, Compound I-087 P2X purinoceptor 3 Homo sapiens 107 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271586 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271586&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295418 378153414 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655427 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cc(ccn3)C(F)(F)F)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271587 US10065941, Compound I-088::US9732060, Compound I-088 P2X purinoceptor 3 Homo sapiens 15.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271587 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271587&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295419 378153415 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655428 CCOC(=O)C[C@H](O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(F)cn3)cc2)n(Cc2ccc(Cl)cc2)c1=O 271588 US10065941, Compound I-089::US9732060, Compound I-089 P2X purinoceptor 3 Homo sapiens 8.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271588 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271588&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752184 378153416 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655429 O[C@@H](CC(O)=O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(F)cn3)cc2)n(Cc2ccc(Cl)cc2)c1=O 271589 US10065941, Compound I-090::US9732060, Compound I-090 P2X purinoceptor 3 Homo sapiens 72.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271589 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271589&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295420 378153417 C03834 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655430 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3cc(Cl)ccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271590 US10065941, Compound I-091::US9732060, Compound I-091 P2X purinoceptor 3 Homo sapiens 10.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271590 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271590&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295421 378153418 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655431 CC(C)(Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cc(ccn3)C(F)(F)F)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O InChI=1S/C27H23ClF3N5O5/c1-26(2,22(37)38)15-36-24(39)34-23(35(25(36)40)14-16-3-5-18(28)6-4-16)33-19-7-9-20(10-8-19)41-21-13-17(11-12-32-21)27(29,30)31/h3-13H,14-15H2,1-2H3,(H,37,38)(H,33,34,39) BPMHGKNWDOVNQX-UHFFFAOYSA-N 271591 US10065941, Compound I-092::US9732060, Compound I-092 P2X purinoceptor 3 Homo sapiens 68.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271591 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271591&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752257 378153419 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655432 COc1ccc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n2Cc2ccc(Cl)cc2)nc1 InChI=1S/C27H26ClN5O6/c1-27(2,23(34)35)16-33-25(36)31-24(32(26(33)37)15-17-4-6-18(28)7-5-17)30-19-8-10-20(11-9-19)39-22-13-12-21(38-3)14-29-22/h4-14H,15-16H2,1-3H3,(H,34,35)(H,30,31,36) FAUNSQBLHRELKM-UHFFFAOYSA-N 271592 US10065941, Compound I-093::US9732060, Compound I-093 P2X purinoceptor 3 Homo sapiens 16.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271592 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271592&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752256 378153420 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655433 COc1ccc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n([C@@H](C)[C@@H](C)C(O)=O)c(=O)n2Cc2ccc(Cl)cc2)nc1 271593 US10065941, Compound I-094::US9732060, Compound I-094 P2X purinoceptor 3 Homo sapiens 11.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271593 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271593&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752258 378153421 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655434 COC(=O)[C@H](C)[C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3ncccc3F)cc2)n(Cc2ccc(C)cc2)c1=O 271594 US10065941, Compound I-095::US9732060, Compound I-095 P2X purinoceptor 3 Homo sapiens 9.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271594 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271594&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295422 378153422 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655435 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3ncccc3F)cc2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 271595 US10065941, Compound I-096::US9732060, Compound I-096 P2X purinoceptor 3 Homo sapiens 8.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271595 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271595&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752321 378153423 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655436 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(Cl)cn3)cc2)n(Cc2ccc(C)cc2)c1=O 271596 US10065941, Compound I-097::US9732060, Compound I-097 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271596 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271596&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752312 378153424 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655437 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(Cl)cn3)cc2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C28H28ClN5O5/c1-18-5-7-19(8-6-18)16-33-25(32-26(36)34(27(33)37)17-28(2,3)24(35)38-4)31-21-10-12-22(13-11-21)39-23-14-9-20(29)15-30-23/h5-15H,16-17H2,1-4H3,(H,31,32,36) UEDVVEREQMWTIV-UHFFFAOYSA-N 271597 US10065941, Compound I-098::US9732060, Compound I-098 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271597 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271597&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752322 378153425 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655438 CO[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ncccc3F)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(=O)OC 271598 US10065941, Compound I-099::US9732060, Compound I-099 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271598 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271598&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752304 378153426 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655439 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(Cl)cn3)cc2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 271599 US10065941, Compound I-100::US9732060, Compound I-100 P2X purinoceptor 3 Homo sapiens 4.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271599 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271599&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752313 378153427 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655440 Cc1ccc(Cn2c(=O)n(CC(C)(C)C(O)=O)c(=O)[nH]\c2=N/c2ccc(Oc3ccc(Cl)cn3)cc2)cc1 InChI=1S/C27H26ClN5O5/c1-17-4-6-18(7-5-17)15-32-24(31-25(36)33(26(32)37)16-27(2,3)23(34)35)30-20-9-11-21(12-10-20)38-22-13-8-19(28)14-29-22/h4-14H,15-16H2,1-3H3,(H,34,35)(H,30,31,36) DXWIIEZOAVIQDF-UHFFFAOYSA-N 271600 US10065941, Compound I-101::US9732060, Compound I-101 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271600 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271600&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752108 378153428 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655441 CO[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ncccc3F)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271601 US10065941, Compound I-102::US9732060, Compound I-102 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271601 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271601&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752105 378153429 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655442 COC(=O)[C@H](C)[C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(F)cn3)cc2)n(Cc2ccc(C)cc2)c1=O 271602 US10065941, Compound I-103::US9732060, Compound I-103 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271602 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271602&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752103 378153430 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655443 COC(=O)[C@H](C)[C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(F)n3)cc2)n(Cc2ccc(C)cc2)c1=O 271603 US10065941, Compound I-104::US9732060, Compound I-104 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271603 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271603&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752106 378153431 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655444 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(F)cn3)cc2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 271604 US10065941, Compound I-105::US9732060, Compound I-105 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271604 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271604&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752104 378153432 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655445 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(F)n3)cc2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 271605 US10065941, Compound I-106::US9732060, Compound I-106 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271605 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271605&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752186 378153433 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655446 COC(=O)[C@H](C)[C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3cc(C)ccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O 271606 US10065941, Compound I-107::US9732060, Compound I-107 P2X purinoceptor 3 Homo sapiens 31.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271606 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271606&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752165 378153434 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655447 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(C)cn3)cc2)n(Cc2ccc(C)cc2)c1=O 271607 US10065941, Compound I-108::US9732060, Compound I-108 P2X purinoceptor 3 Homo sapiens 4.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271607 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271607&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752162 378153435 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655448 COC(=O)[C@H](C)[C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(C)cn3)cc2)n(Cc2ccc(C)cc2)c1=O 271608 US10065941, Compound I-109::US9732060, Compound I-109 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271608 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271608&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752195 378153436 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655449 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(C)cn3)cc2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C29H31N5O5/c1-19-6-9-21(10-7-19)17-33-26(32-27(36)34(28(33)37)18-29(3,4)25(35)38-5)31-22-11-13-23(14-12-22)39-24-15-8-20(2)16-30-24/h6-16H,17-18H2,1-5H3,(H,31,32,36) PWWKPOCHRQULHN-UHFFFAOYSA-N 271609 US10065941, Compound I-110::US9732060, Compound I-110 P2X purinoceptor 3 Homo sapiens 4.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271609 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271609&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 86567076 378153437 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655450 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3cc(C)ccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271610 US10065941, Compound I-111::US9732060, Compound I-111 P2X purinoceptor 3 Homo sapiens 9.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271610 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271610&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752264 378153438 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655451 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(C)cn3)cc2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 271611 US10065941, Compound I-112::US9732060, Compound I-112 P2X purinoceptor 3 Homo sapiens 4.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271611 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271611&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752279 378153439 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655452 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(C)cn3)cc2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 271612 US10065941, Compound I-113::US9732060, Compound I-113 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271612 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271612&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752273 378153440 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655453 Cc1ccc(Cn2c(=O)n(CC(C)(C)C(O)=O)c(=O)[nH]\c2=N/c2ccc(Oc3ccc(C)cn3)cc2)cc1 InChI=1S/C28H29N5O5/c1-18-5-8-20(9-6-18)16-32-25(31-26(36)33(27(32)37)17-28(3,4)24(34)35)30-21-10-12-22(13-11-21)38-23-14-7-19(2)15-29-23/h5-15H,16-17H2,1-4H3,(H,34,35)(H,30,31,36) PCHZTGCPGFSPKI-UHFFFAOYSA-N 271613 US10065941, Compound I-114::US9732060, Compound I-114 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271613 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271613&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752289 378153441 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655454 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(Cl)n3)cc2)n(Cc2ccc(C)cc2)c1=O 271614 US10065941, Compound I-115::US9732060, Compound I-115 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271614 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271614&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752268 378153442 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655455 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(Cl)n3)cc2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C28H28ClN5O5/c1-18-8-10-19(11-9-18)16-33-25(32-26(36)34(27(33)37)17-28(2,3)24(35)38-4)30-20-12-14-21(15-13-20)39-23-7-5-6-22(29)31-23/h5-15H,16-17H2,1-4H3,(H,30,32,36) PLEHORDHPPBENR-UHFFFAOYSA-N 271615 US10065941, Compound I-116::US9732060, Compound I-116 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271615 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271615&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752188 378153443 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655456 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ncccc3Cl)cc2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 271616 US10065941, Compound I-117::US9732060, Compound I-117 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271616 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271616&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752220 378153444 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655457 Cc1ccc(Cn2c(=O)n(CC(C)(C)C(O)=O)c(=O)[nH]\c2=N/c2ccc(Oc3ncccc3Cl)cc2)cc1 InChI=1S/C27H26ClN5O5/c1-17-6-8-18(9-7-17)15-32-24(31-25(36)33(26(32)37)16-27(2,3)23(34)35)30-19-10-12-20(13-11-19)38-22-21(28)5-4-14-29-22/h4-14H,15-16H2,1-3H3,(H,34,35)(H,30,31,36) RDLRCBJETFQDKP-UHFFFAOYSA-N 271617 US10065941, Compound I-118::US9732060, Compound I-118 P2X purinoceptor 3 Homo sapiens 9.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271617 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271617&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752197 378153445 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655458 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(Cl)n3)cc2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 271618 US10065941, Compound I-119::US9732060, Compound I-119 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271618 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271618&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752169 378153446 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655459 COC(=O)[C@H](C)[C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(Cl)cn3)cc2)n(Cc2ccc(C)cc2)c1=O 271619 US10065941, Compound I-120::US9732060, Compound I-120 P2X purinoceptor 3 Homo sapiens 9.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271619 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271619&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752221 378153447 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655460 CO[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(F)cn3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(=O)OC 271620 US10065941, Compound I-121::US9732060, Compound I-121 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271620 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271620&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752306 378153448 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655461 CO[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(F)n3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(=O)OC 271621 US10065941, Compound I-122::US9732060, Compound I-122 P2X purinoceptor 3 Homo sapiens 4.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271621 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271621&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752325 378153449 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655462 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(Cl)cn3)cc2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 271622 US10065941, Compound I-123::US9732060, Compound I-123 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271622 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271622&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752307 378153450 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655463 CO[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(F)cn3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271623 US10065941, Compound I-124::US9732060, Compound I-124 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271623 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271623&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752314 378153451 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655464 CO[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(F)n3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271624 US10065941, Compound I-125::US9732060, Compound I-125 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271624 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271624&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752317 378153452 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655465 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O 271625 US10065941, Compound I-126::US9732060, Compound I-126 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271625 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271625&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 86567146 378153453 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655466 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271626 US10065941, Compound I-127::US9732060, Compound I-127 P2X purinoceptor 3 Homo sapiens 4.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271626 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271626&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752163 378153454 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655467 Cc1ccc(Cn2c(=O)n(CC(C)(C)C(O)=O)c(=O)[nH]\c2=N/c2ccc(Oc3cccc(Cl)n3)cc2)cc1 InChI=1S/C27H26ClN5O5/c1-17-7-9-18(10-8-17)15-32-24(31-25(36)33(26(32)37)16-27(2,3)23(34)35)29-19-11-13-20(14-12-19)38-22-6-4-5-21(28)30-22/h4-14H,15-16H2,1-3H3,(H,34,35)(H,29,31,36) QGLVKRQTERXNSW-UHFFFAOYSA-N 271627 US10065941, Compound I-128::US9732060, Compound I-128 P2X purinoceptor 3 Homo sapiens 8.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271627 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271627&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752303 378153455 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655468 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(F)cn3)cc2)n(Cc2ccc(C)cc2)c1=O 271535 US10065941, Compound I-036::US10065941, Compound I-129::US9732060, Compound I-129 P2X purinoceptor 3 Homo sapiens 4.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271535 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271535&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752331 378153363 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655469 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(F)cn3)cc2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 271539 US10065941, Compound I-040::US10065941, Compound I-130::US9732060, Compound I-130 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271539 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271539&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752335 378153367 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655470 COC(=O)[C@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O 271630 US10065941, Compound I-131::US9732060, Compound I-131 P2X purinoceptor 3 Homo sapiens 8.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271630 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271630&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752349 378153456 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655471 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(OC(F)F)cn3)cc2)n(Cc2ccc(C)cc2)c1=O 271631 US10065941, Compound I-132::US9732060, Compound I-132 P2X purinoceptor 3 Homo sapiens 8.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271631 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271631&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752350 378153457 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655854 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(F)cn3)cc2)n(Cc2ccc(Cl)s2)c1=O)C(O)=O 272053 US10065941, Compound I-274::US9732060, Compound I-274 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272053 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272053&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752128 378153877 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655855 CCc1ccc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n2Cc2ccc(C)cc2)nc1 272054 US10065941, Compound I-275::US9732060, Compound I-275 P2X purinoceptor 3 Homo sapiens 4.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272054 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272054&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295459 378153878 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655856 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ncccc3F)c(C)c2)n(Cc2ccc(Cl)s2)c1=O)C(O)=O 272055 US10065941, Compound I-276::US9732060, Compound I-276 P2X purinoceptor 3 Homo sapiens 19.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272055 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272055&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295460 378153879 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655857 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(cn3)S(C)(=O)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O 272056 US10065941, Compound I-277::US9732060, Compound I-277 P2X purinoceptor 3 Homo sapiens 4.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272056 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272056&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295462 378153880 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655858 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(cn3)S(C)(=O)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 272057 US10065941, Compound I-278::US9732060, Compound I-278 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272057 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272057&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295461 378153881 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655859 OC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(F)n3)cc2)n(Cc2ccc(CF)cc2)c1=O InChI=1S/C25H21F2N5O5/c26-14-16-4-6-17(7-5-16)15-32-23(30-24(35)31(25(32)36)13-12-22(33)34)28-18-8-10-19(11-9-18)37-21-3-1-2-20(27)29-21/h1-11H,12-15H2,(H,33,34)(H,28,30,35) WIFQGDFHLPPRIU-UHFFFAOYSA-N 271941 US10065941, Compound R-275::US9732060, Compound R-275 P2X purinoceptor 3 Homo sapiens 23.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271941 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271941&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752247 378153766 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655860 OC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ncccc3F)cc2)n(Cc2ccc(CF)cc2)c1=O InChI=1S/C25H21F2N5O5/c26-14-16-3-5-17(6-4-16)15-32-23(30-24(35)31(25(32)36)13-11-21(33)34)29-18-7-9-19(10-8-18)37-22-20(27)2-1-12-28-22/h1-10,12H,11,13-15H2,(H,33,34)(H,29,30,35) BDGQPLXXZCOIBY-UHFFFAOYSA-N 271943 US10065941, Compound R-276::US9732060, Compound R-276 P2X purinoceptor 3 Homo sapiens 42.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271943 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271943&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752244 378153768 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655861 Cc1ccc(Cn2c(=O)n(CCCC(O)=O)c(=O)[nH]\c2=N/c2ccc(Oc3ncccc3F)cc2)cc1 InChI=1S/C26H24FN5O5/c1-17-6-8-18(9-7-17)16-32-24(30-25(35)31(26(32)36)15-3-5-22(33)34)29-19-10-12-20(13-11-19)37-23-21(27)4-2-14-28-23/h2,4,6-14H,3,5,15-16H2,1H3,(H,33,34)(H,29,30,35) ATBCVSIBQDISOQ-UHFFFAOYSA-N 271945 US10065941, Compound R-277::US9732060, Compound R-277 P2X purinoceptor 3 Homo sapiens 14.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271945 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271945&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752245 378153770 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655862 Cc1ccc(Cn2c(=O)n(CCCC(O)=O)c(=O)[nH]\c2=N/c2ccc(Oc3ccc(F)cn3)cc2)cc1 InChI=1S/C26H24FN5O5/c1-17-4-6-18(7-5-17)16-32-24(30-25(35)31(26(32)36)14-2-3-23(33)34)29-20-9-11-21(12-10-20)37-22-13-8-19(27)15-28-22/h4-13,15H,2-3,14,16H2,1H3,(H,33,34)(H,29,30,35) SLZIAROFBLAYBQ-UHFFFAOYSA-N 271947 US10065941, Compound R-278::US9732060, Compound R-278 P2X purinoceptor 3 Homo sapiens 15.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271947 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271947&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752248 378153772 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655863 Cc1ccc(Cn2c(=O)n(CCCC(O)=O)c(=O)[nH]\c2=N/c2ccc(Oc3cccc(F)n3)cc2)cc1 InChI=1S/C26H24FN5O5/c1-17-7-9-18(10-8-17)16-32-24(30-25(35)31(26(32)36)15-3-6-23(33)34)28-19-11-13-20(14-12-19)37-22-5-2-4-21(27)29-22/h2,4-5,7-14H,3,6,15-16H2,1H3,(H,33,34)(H,28,30,35) HERSQUYGRISQKR-UHFFFAOYSA-N 271949 US10065941, Compound R-279::US9732060, Compound R-279 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271949 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271949&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752246 378153774 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655864 Cc1ccc(Cn2c(=O)n(CCC(O)=O)c(=O)[nH]\c2=N/c2ccc(Oc3ccccn3)c(F)c2)cc1 InChI=1S/C25H22FN5O5/c1-16-5-7-17(8-6-16)15-31-23(29-24(34)30(25(31)35)13-11-22(32)33)28-18-9-10-20(19(26)14-18)36-21-4-2-3-12-27-21/h2-10,12,14H,11,13,15H2,1H3,(H,32,33)(H,28,29,34) HZQRMWFVLQSWSX-UHFFFAOYSA-N 271951 US10065941, Compound R-280::US9732060, Compound R-280 P2X purinoceptor 3 Homo sapiens 9.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271951 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271951&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295671 378153776 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655865 OC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H19ClFN5O5/c25-16-6-4-15(5-7-16)14-31-22(29-23(34)30(24(31)35)12-10-21(32)33)28-17-8-9-19(18(26)13-17)36-20-3-1-2-11-27-20/h1-9,11,13H,10,12,14H2,(H,32,33)(H,28,29,34) MAHIPYQAKQUSJL-UHFFFAOYSA-N 271953 US10065941, Compound R-281::US9732060, Compound R-281 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271953 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271953&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752346 378153778 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655866 Cc1ccc(Cn2c(=O)n(CCC(O)=O)c(=O)[nH]\c2=N/c2ccc(Oc3ccccn3)c(C)c2)cc1 InChI=1S/C26H25N5O5/c1-17-6-8-19(9-7-17)16-31-24(29-25(34)30(26(31)35)14-12-23(32)33)28-20-10-11-21(18(2)15-20)36-22-5-3-4-13-27-22/h3-11,13,15H,12,14,16H2,1-2H3,(H,32,33)(H,28,29,34) KWYDOWGTSATFLE-UHFFFAOYSA-N 271955 US10065941, Compound R-282::US9732060, Compound R-282 P2X purinoceptor 3 Homo sapiens 23.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271955 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271955&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752343 378153780 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655867 Cc1cc(ccc1Oc1ccccn1)\N=c1/[nH]c(=O)n(CCC(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C25H22ClN5O5/c1-16-14-19(9-10-20(16)36-21-4-2-3-12-27-21)28-23-29-24(34)30(13-11-22(32)33)25(35)31(23)15-17-5-7-18(26)8-6-17/h2-10,12,14H,11,13,15H2,1H3,(H,32,33)(H,28,29,34) ZMIMMGQVQOGJTM-UHFFFAOYSA-N 271957 US10065941, Compound R-283::US9732060, Compound R-283 P2X purinoceptor 3 Homo sapiens 28.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271957 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271957&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752347 378153782 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655868 OC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(Cl)cn3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H19Cl2N5O5/c25-16-3-1-15(2-4-16)14-31-22(29-23(34)30(24(31)35)12-11-21(32)33)28-18-6-8-19(9-7-18)36-20-10-5-17(26)13-27-20/h1-10,13H,11-12,14H2,(H,32,33)(H,28,29,34) CGRNXHZLJUICRL-UHFFFAOYSA-N 271959 US10065941, Compound R-284::US9732060, Compound R-284 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271959 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271959&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752344 378153784 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655869 Cc1ccc(Cn2c(=O)n(CCC(O)=O)c(=O)[nH]\c2=N/c2ccc(Oc3ccc(Cl)cn3)cc2)cc1 InChI=1S/C25H22ClN5O5/c1-16-2-4-17(5-3-16)15-31-23(29-24(34)30(25(31)35)13-12-22(32)33)28-19-7-9-20(10-8-19)36-21-11-6-18(26)14-27-21/h2-11,14H,12-13,15H2,1H3,(H,32,33)(H,28,29,34) XQAHSJCLMAGHPK-UHFFFAOYSA-N 271961 US10065941, Compound R-285::US9732060, Compound R-285 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271961 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271961&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752259 378153786 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655870 COC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(F)n3)cc2)n(Cc2ccc(CF)cc2)c1=O InChI=1S/C26H23F2N5O5/c1-37-23(34)13-14-32-25(35)31-24(33(26(32)36)16-18-7-5-17(15-27)6-8-18)29-19-9-11-20(12-10-19)38-22-4-2-3-21(28)30-22/h2-12H,13-16H2,1H3,(H,29,31,35) QQWISUYCHJNOFS-UHFFFAOYSA-N 271963 US10065941, Compound R-286::US9732060, Compound R-286 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271963 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271963&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752281 378153788 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655871 COC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(Cl)cn3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H21Cl2N5O5/c1-36-22(33)12-13-31-24(34)30-23(32(25(31)35)15-16-2-4-17(26)5-3-16)29-19-7-9-20(10-8-19)37-21-11-6-18(27)14-28-21/h2-11,14H,12-13,15H2,1H3,(H,29,30,34) KPOFBJFBAQLXMI-UHFFFAOYSA-N 271965 US10065941, Compound R-287::US9732060, Compound R-287 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271965 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271965&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295672 378153790 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655872 COC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ncccc3F)cc2)n(Cc2ccc(CF)cc2)c1=O InChI=1S/C26H23F2N5O5/c1-37-22(34)12-14-32-25(35)31-24(33(26(32)36)16-18-6-4-17(15-27)5-7-18)30-19-8-10-20(11-9-19)38-23-21(28)3-2-13-29-23/h2-11,13H,12,14-16H2,1H3,(H,30,31,35) YHVSDTMNCPWGTM-UHFFFAOYSA-N 271967 US10065941, Compound R-288::US9732060, Compound R-288 P2X purinoceptor 3 Homo sapiens 12.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271967 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271967&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752265 378153792 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655873 COC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(Cl)cn3)cc2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C26H24ClN5O5/c1-17-3-5-18(6-4-17)16-32-24(30-25(34)31(26(32)35)14-13-23(33)36-2)29-20-8-10-21(11-9-20)37-22-12-7-19(27)15-28-22/h3-12,15H,13-14,16H2,1-2H3,(H,29,30,34) KQMYLQNUSDISOI-UHFFFAOYSA-N 271969 US10065941, Compound R-289::US9732060, Compound R-289 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271969 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271969&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752260 378153794 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655874 COC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)c(C)c2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C27H27N5O5/c1-18-7-9-20(10-8-18)17-32-25(30-26(34)31(27(32)35)15-13-24(33)36-3)29-21-11-12-22(19(2)16-21)37-23-6-4-5-14-28-23/h4-12,14,16H,13,15,17H2,1-3H3,(H,29,30,34) MDLDKRZRQMPQJH-UHFFFAOYSA-N 271971 US10065941, Compound R-290::US9732060, Compound R-290 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271971 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271971&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752391 378153796 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655875 COC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H24ClN5O5/c1-17-15-20(10-11-21(17)37-22-5-3-4-13-28-22)29-24-30-25(34)31(14-12-23(33)36-2)26(35)32(24)16-18-6-8-19(27)9-7-18/h3-11,13,15H,12,14,16H2,1-2H3,(H,29,30,34) BQEVANLSYANDHH-UHFFFAOYSA-N 271973 US10065941, Compound R-291::US9732060, Compound R-291 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271973 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271973&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752389 378153798 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655876 COC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)c(F)c2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C26H24FN5O5/c1-17-6-8-18(9-7-17)16-32-24(30-25(34)31(26(32)35)14-12-23(33)36-2)29-19-10-11-21(20(27)15-19)37-22-5-3-4-13-28-22/h3-11,13,15H,12,14,16H2,1-2H3,(H,29,30,34) YTCBWVPNRZSTOA-UHFFFAOYSA-N 271975 US10065941, Compound R-292::US9732060, Compound R-292 P2X purinoceptor 3 Homo sapiens 4.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271975 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271975&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295673 378153800 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655877 COC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H21ClFN5O5/c1-36-22(33)11-13-31-24(34)30-23(32(25(31)35)15-16-5-7-17(26)8-6-16)29-18-9-10-20(19(27)14-18)37-21-4-2-3-12-28-21/h2-10,12,14H,11,13,15H2,1H3,(H,29,30,34) BPMLFIMUNBQLTG-UHFFFAOYSA-N 271977 US10065941, Compound R-293::US9732060, Compound R-293 P2X purinoceptor 3 Homo sapiens 4.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271977 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271977&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752385 378153802 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655878 CCOC(=O)CCCn1c(=O)[nH]\c(=N/c2ccc(Oc3ncccc3F)cc2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C28H28FN5O5/c1-3-38-24(35)7-5-17-33-27(36)32-26(34(28(33)37)18-20-10-8-19(2)9-11-20)31-21-12-14-22(15-13-21)39-25-23(29)6-4-16-30-25/h4,6,8-16H,3,5,7,17-18H2,1-2H3,(H,31,32,36) ZHNWXPKKVRRVCI-UHFFFAOYSA-N 271979 US10065941, Compound R-294::US9732060, Compound R-294 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271979 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271979&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752386 378153804 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655879 CCOC(=O)CCCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(F)cn3)cc2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C28H28FN5O5/c1-3-38-25(35)5-4-16-33-27(36)32-26(34(28(33)37)18-20-8-6-19(2)7-9-20)31-22-11-13-23(14-12-22)39-24-15-10-21(29)17-30-24/h6-15,17H,3-5,16,18H2,1-2H3,(H,31,32,36) CCHTUSFFNQDRJH-UHFFFAOYSA-N 271981 US10065941, Compound R-295::US9732060, Compound R-295 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271981 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271981&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752382 378153806 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655880 CCOC(=O)CCCn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(F)n3)cc2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C28H28FN5O5/c1-3-38-25(35)8-5-17-33-27(36)32-26(34(28(33)37)18-20-11-9-19(2)10-12-20)30-21-13-15-22(16-14-21)39-24-7-4-6-23(29)31-24/h4,6-7,9-16H,3,5,8,17-18H2,1-2H3,(H,30,32,36) BITSFVQWUCICOI-UHFFFAOYSA-N 271983 US10065941, Compound R-296::US9732060, Compound R-296 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271983 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271983&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752372 378153808 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655881 OC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)c(Cl)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H19Cl2N5O5/c25-16-6-4-15(5-7-16)14-31-22(29-23(34)30(24(31)35)12-10-21(32)33)28-17-8-9-19(18(26)13-17)36-20-3-1-2-11-27-20/h1-9,11,13H,10,12,14H2,(H,32,33)(H,28,29,34) FFFVHDAXDQUDQG-UHFFFAOYSA-N 271985 US10065941, Compound R-297::US9732060, Compound R-297 P2X purinoceptor 3 Homo sapiens 8.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271985 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271985&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752387 378153810 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655882 Cc1ccc(Cn2c(=O)n(CCC(O)=O)c(=O)[nH]\c2=N/c2ccc(Oc3ccccn3)c(Cl)c2)cc1 InChI=1S/C25H22ClN5O5/c1-16-5-7-17(8-6-16)15-31-23(29-24(34)30(25(31)35)13-11-22(32)33)28-18-9-10-20(19(26)14-18)36-21-4-2-3-12-27-21/h2-10,12,14H,11,13,15H2,1H3,(H,32,33)(H,28,29,34) JICVDYHZXWIKQZ-UHFFFAOYSA-N 271987 US10065941, Compound R-298::US9732060, Compound R-298 P2X purinoceptor 3 Homo sapiens 9.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271987 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271987&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752383 378153812 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655883 CC(=O)c1cccc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(CCC(O)=O)c(=O)n2Cc2ccc(Cl)cc2)n1 InChI=1S/C26H22ClN5O6/c1-16(33)21-3-2-4-22(29-21)38-20-11-9-19(10-12-20)28-24-30-25(36)31(14-13-23(34)35)26(37)32(24)15-17-5-7-18(27)8-6-17/h2-12H,13-15H2,1H3,(H,34,35)(H,28,30,36) GLOLUYQIMMOKHN-UHFFFAOYSA-N 271989 US10065941, Compound R-299::US9732060, Compound R-299 P2X purinoceptor 3 Homo sapiens 20.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271989 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271989&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752170 378153814 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655884 COC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)c(Cl)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H21Cl2N5O5/c1-36-22(33)11-13-31-24(34)30-23(32(25(31)35)15-16-5-7-17(26)8-6-16)29-18-9-10-20(19(27)14-18)37-21-4-2-3-12-28-21/h2-10,12,14H,11,13,15H2,1H3,(H,29,30,34) QRNIHVKXQPIHIP-UHFFFAOYSA-N 271991 US10065941, Compound R-300::US9732060, Compound R-300 P2X purinoceptor 3 Homo sapiens 8.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271991 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271991&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752189 378153816 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655885 COC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)c(Cl)c2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C26H24ClN5O5/c1-17-6-8-18(9-7-17)16-32-24(30-25(34)31(26(32)35)14-12-23(33)36-2)29-19-10-11-21(20(27)15-19)37-22-5-3-4-13-28-22/h3-11,13,15H,12,14,16H2,1-2H3,(H,29,30,34) VSMAJCFXSMVGMC-UHFFFAOYSA-N 271993 US10065941, Compound R-301::US9732060, Compound R-301 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271993 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271993&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752222 378153818 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655886 COC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(n3)C(C)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C27H24ClN5O6/c1-17(34)22-4-3-5-23(30-22)39-21-12-10-20(11-13-21)29-25-31-26(36)32(15-14-24(35)38-2)27(37)33(25)16-18-6-8-19(28)9-7-18/h3-13H,14-16H2,1-2H3,(H,29,31,36) QJXQUDLXIKYZBY-UHFFFAOYSA-N 271995 US10065941, Compound R-302::US9732060, Compound R-302 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271995 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271995&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295674 378153820 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655887 COC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(cn3)C(C)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C27H24ClN5O6/c1-17(34)19-5-12-23(29-15-19)39-22-10-8-21(9-11-22)30-25-31-26(36)32(14-13-24(35)38-2)27(37)33(25)16-18-3-6-20(28)7-4-18/h3-12,15H,13-14,16H2,1-2H3,(H,30,31,36) ZPUADLGXCXLGEQ-UHFFFAOYSA-N 271997 US10065941, Compound R-303::US9732060, Compound R-303 P2X purinoceptor 3 Homo sapiens 3.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271997 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271997&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295675 378153822 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655888 COC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(cn3)C(C)O)cc2)n(Cc2ccc(Cl)cc2)c1=O 271999 US10065941, Compound R-304::US9732060, Compound R-304 P2X purinoceptor 3 Homo sapiens 4.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271999 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271999&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295676 378153824 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655889 CC(=O)c1ccc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(CCC(O)=O)c(=O)n2Cc2ccc(Cl)cc2)nc1 InChI=1S/C26H22ClN5O6/c1-16(33)18-4-11-22(28-14-18)38-21-9-7-20(8-10-21)29-24-30-25(36)31(13-12-23(34)35)26(37)32(24)15-17-2-5-19(27)6-3-17/h2-11,14H,12-13,15H2,1H3,(H,34,35)(H,29,30,36) XAJWCIYYMGKVSC-UHFFFAOYSA-N 272001 US10065941, Compound R-305::US9732060, Compound R-305 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272001 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272001&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295677 378153826 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655890 CC(O)c1ccc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(CCC(O)=O)c(=O)n2Cc2ccc(Cl)cc2)nc1 272003 US10065941, Compound R-306::US9732060, Compound R-306 P2X purinoceptor 3 Homo sapiens 14.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272003 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272003&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295678 378153828 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655891 CCOC(=O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(Cc2ccc(F)cc2)c1=O InChI=1S/C25H22FN5O5/c1-2-35-22(32)16-31-24(33)29-23(30(25(31)34)15-17-6-8-18(26)9-7-17)28-19-10-12-20(13-11-19)36-21-5-3-4-14-27-21/h3-14H,2,15-16H2,1H3,(H,28,29,33) FTHOQGWSLSKJCX-UHFFFAOYSA-N 272005 US10065941, Compound R-307::US9732060, Compound R-307 P2X purinoceptor 3 Homo sapiens 13.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272005 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272005&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752302 378153830 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655892 CCOC(=O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(F)cn3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H21ClFN5O5/c1-2-36-22(33)15-32-24(34)30-23(31(25(32)35)14-16-3-5-17(26)6-4-16)29-19-8-10-20(11-9-19)37-21-12-7-18(27)13-28-21/h3-13H,2,14-15H2,1H3,(H,29,30,34) LZXTWYDQLCXYBJ-UHFFFAOYSA-N 272007 US10065941, Compound R-309::US9732060, Compound R-309 P2X purinoceptor 3 Homo sapiens 4.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272007 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272007&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295679 378153832 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655893 CCOC(=O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(Cl)cn3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H21Cl2N5O5/c1-2-36-22(33)15-32-24(34)30-23(31(25(32)35)14-16-3-5-17(26)6-4-16)29-19-8-10-20(11-9-19)37-21-12-7-18(27)13-28-21/h3-13H,2,14-15H2,1H3,(H,29,30,34) IDHUNPPWIBAJJY-UHFFFAOYSA-N 272009 US10065941, Compound R-310::US9732060, Compound R-310 P2X purinoceptor 3 Homo sapiens 4.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272009 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272009&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295682 378153834 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655894 OC(=O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(F)cn3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H17ClFN5O5/c24-15-3-1-14(2-4-15)12-29-21(28-22(33)30(23(29)34)13-20(31)32)27-17-6-8-18(9-7-17)35-19-10-5-16(25)11-26-19/h1-11H,12-13H2,(H,31,32)(H,27,28,33) GRSFGWFDUAJOLJ-UHFFFAOYSA-N 272011 US10065941, Compound R-311::US9732060, Compound R-311 P2X purinoceptor 3 Homo sapiens 428 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272011 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272011&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752251 378153836 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655895 OC(=O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(Cl)cn3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H17Cl2N5O5/c24-15-3-1-14(2-4-15)12-29-21(28-22(33)30(23(29)34)13-20(31)32)27-17-6-8-18(9-7-17)35-19-10-5-16(25)11-26-19/h1-11H,12-13H2,(H,31,32)(H,27,28,33) JTIYNNXDVVNETA-UHFFFAOYSA-N 272013 US10065941, Compound R-312::US9732060, Compound R-312 P2X purinoceptor 3 Homo sapiens 350 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272013 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272013&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752252 378153838 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655896 CCOC(=O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(cn3)C#N)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H21ClN6O5/c1-2-37-23(34)16-33-25(35)31-24(32(26(33)36)15-17-3-6-19(27)7-4-17)30-20-8-10-21(11-9-20)38-22-12-5-18(13-28)14-29-22/h3-12,14H,2,15-16H2,1H3,(H,30,31,35) MURBJSZYMOUPML-UHFFFAOYSA-N 272015 US10065941, Compound R-313::US9732060, Compound R-313 P2X purinoceptor 3 Homo sapiens 3.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272015 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272015&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295680 378153840 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655897 OC(=O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(cn3)C#N)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H17ClN6O5/c25-17-4-1-15(2-5-17)13-30-22(29-23(34)31(24(30)35)14-21(32)33)28-18-6-8-19(9-7-18)36-20-10-3-16(11-26)12-27-20/h1-10,12H,13-14H2,(H,32,33)(H,28,29,34) DPLICNAZDYZBIZ-UHFFFAOYSA-N 272017 US10065941, Compound R-314::US9732060, Compound R-314 P2X purinoceptor 3 Homo sapiens 48.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272017 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272017&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295681 378153842 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655472 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(OC(F)F)cn3)cc2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C29H29F2N5O6/c1-18-5-7-19(8-6-18)16-35-26(34-27(38)36(28(35)39)17-29(2,3)24(37)40-4)33-20-9-11-21(12-10-20)41-23-14-13-22(15-32-23)42-25(30)31/h5-15,25H,16-17H2,1-4H3,(H,33,34,38) LBJZGZMIIBOMIG-UHFFFAOYSA-N 271632 US10065941, Compound I-133::US9732060, Compound I-133 P2X purinoceptor 3 Homo sapiens 8.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271632 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271632&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752352 378153458 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655473 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3cc(ccn3)C#N)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271633 US10065941, Compound I-134::US9732060, Compound I-134 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271633 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271633&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752353 378153459 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655474 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(OC(F)F)cn3)cc2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 271634 US10065941, Compound I-135::US9732060, Compound I-135 P2X purinoceptor 3 Homo sapiens 4.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271634 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271634&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752351 378153460 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655475 Cc1ccc(Cn2c(=O)n(CC(C)(C)C(O)=O)c(=O)[nH]\c2=N/c2ccc(Oc3ccc(OC(F)F)cn3)cc2)cc1 InChI=1S/C28H27F2N5O6/c1-17-4-6-18(7-5-17)15-34-25(33-26(38)35(27(34)39)16-28(2,3)23(36)37)32-19-8-10-20(11-9-19)40-22-13-12-21(14-31-22)41-24(29)30/h4-14,24H,15-16H2,1-3H3,(H,36,37)(H,32,33,38) YSHQUEFTCQOIOI-UHFFFAOYSA-N 271635 US10065941, Compound I-136::US9732060, Compound I-136 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271635 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271635&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752291 378153461 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655476 COC(=O)[C@H](C)[C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(OC(F)F)cn3)cc2)n(Cc2ccc(C)cc2)c1=O 271636 US10065941, Compound I-137::US9732060, Compound I-137 P2X purinoceptor 3 Homo sapiens 14.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271636 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271636&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752271 378153462 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655477 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(OC(F)F)cn3)cc2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 271637 US10065941, Compound I-138::US10065941, Compound R-216::US9732060, Compound R-216 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271637 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271637&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752285 378153463 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655478 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cc(OC)ccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O 271638 US10065941, Compound I-139::US9732060, Compound I-139 P2X purinoceptor 3 Homo sapiens 10.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271638 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271638&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752272 378153464 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655479 COC(=O)[C@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(Cc2ccc(C)cc2)c1=O 271639 US10065941, Compound I-140::US9732060, Compound I-140 P2X purinoceptor 3 Homo sapiens 3.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271639 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271639&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752161 378153465 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655480 C[C@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271640 US10065941, Compound I-141::US9732060, Compound I-141 P2X purinoceptor 3 Homo sapiens 14.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271640 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271640&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 86567144 378153466 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655481 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(Cc2ccc(C)cc2)c1=O 334420 US9732060, Compound I-142 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=334420 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=334420&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68021040 384986580 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655482 CO[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(=O)OC 271642 US10065941, Compound I-143::US9732060, Compound I-143 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271642 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271642&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752348 378153468 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655483 COC(=O)[C@H](C)[C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O 271643 US10065941, Compound I-144::US9732060, Compound I-144 P2X purinoceptor 3 Homo sapiens 9.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271643 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271643&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295425 378153469 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655484 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 334423 US9732060, Compound I-145 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=334423 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=334423&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752067 384986583 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655485 CO[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271645 US10065941, Compound I-146::US9732060, Compound I-146 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271645 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271645&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295426 378153471 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655486 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271646 US10065941, Compound I-147::US9732060, Compound I-147 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271646 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271646&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752230 378153472 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655487 C[C@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 271647 US10065941, Compound I-148::US9732060, Compound I-148 P2X purinoceptor 3 Homo sapiens 9.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271647 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271647&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752200 378153473 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655488 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C27H26ClN5O5/c1-27(2,23(34)37-3)17-33-25(35)31-24(32(26(33)36)16-18-7-9-19(28)10-8-18)30-20-11-13-21(14-12-20)38-22-6-4-5-15-29-22/h4-15H,16-17H2,1-3H3,(H,30,31,35) RBEFUDKJTIITFD-UHFFFAOYSA-N 271648 US10065941, Compound I-149::US9732060, Compound I-149 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271648 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271648&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752223 378153474 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655489 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C28H29N5O5/c1-19-8-10-20(11-9-19)17-32-25(31-26(35)33(27(32)36)18-28(2,3)24(34)37-4)30-21-12-14-22(15-13-21)38-23-7-5-6-16-29-23/h5-16H,17-18H2,1-4H3,(H,30,31,35) GGWDQLSVRFVYNF-UHFFFAOYSA-N 271649 US10065941, Compound I-150::US9732060, Compound I-150 P2X purinoceptor 3 Homo sapiens 4.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271649 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271649&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 86567204 378153475 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655490 COC(=O)[C@@H](C)[C@@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O 271650 US10065941, Compound I-151::US9732060, Compound I-151 P2X purinoceptor 3 Homo sapiens 10.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271650 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271650&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752269 378153476 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655491 C[C@@H]([C@@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271652 US10065941, Compound I-152::US9732060, Compound I-152 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271652 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271652&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752270 378153478 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655492 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ncccc3OC)cc2)n(Cc2ccc(Cl)cc2)c1=O 271654 US10065941, Compound I-153::US9732060, Compound I-153 P2X purinoceptor 3 Homo sapiens 13.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271654 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271654&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752290 378153480 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655493 CC(C)(Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O InChI=1S/C26H24ClN5O5/c1-26(2,22(33)34)16-32-24(35)30-23(31(25(32)36)15-17-6-8-18(27)9-7-17)29-19-10-12-20(13-11-19)37-21-5-3-4-14-28-21/h3-14H,15-16H2,1-2H3,(H,33,34)(H,29,30,35) QXIYPDRPHDQUBK-UHFFFAOYSA-N 271656 US10065941, Compound I-154::US9732060, Compound I-154 P2X purinoceptor 3 Homo sapiens 8.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271656 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271656&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752266 378153482 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655494 Cc1ccc(Cn2c(=O)n(CC(C)(C)C(O)=O)c(=O)[nH]\c2=N/c2ccc(Oc3ccccn3)cc2)cc1 InChI=1S/C27H27N5O5/c1-18-7-9-19(10-8-18)16-31-24(30-25(35)32(26(31)36)17-27(2,3)23(33)34)29-20-11-13-21(14-12-20)37-22-6-4-5-15-28-22/h4-15H,16-17H2,1-3H3,(H,33,34)(H,29,30,35) XJQRYNDTFVPSJC-UHFFFAOYSA-N 271658 US10065941, Compound I-155::US9732060, Compound I-155 P2X purinoceptor 3 Homo sapiens 8.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271658 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271658&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752267 378153484 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655495 COc1cccnc1Oc1ccc(cc1)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 271660 US10065941, Compound I-156::US9732060, Compound I-156 P2X purinoceptor 3 Homo sapiens 12.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271660 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271660&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752095 378153486 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655496 COC(=O)C[C@@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O 271662 US10065941, Compound I-157::US9732060, Compound I-157 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271662 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271662&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752100 378153488 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655497 COC(=O)C[C@@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(F)n3)cc2)n(Cc2ccc(Cl)cc2)c1=O 271664 US10065941, Compound I-158::US9732060, Compound I-158 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271664 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271664&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295427 378153490 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655498 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ncccc3OC)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C28H28ClN5O6/c1-28(2,24(35)39-4)17-34-26(36)32-25(33(27(34)37)16-18-7-9-19(29)10-8-18)31-20-11-13-21(14-12-20)40-23-22(38-3)6-5-15-30-23/h5-15H,16-17H2,1-4H3,(H,31,32,36) WFQKGDPSJURZMD-UHFFFAOYSA-N 271666 US10065941, Compound I-159::US9732060, Compound I-159 P2X purinoceptor 3 Homo sapiens 9.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271666 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271666&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752101 378153492 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655499 COC(=O)C[C@@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(F)cn3)cc2)n(Cc2ccc(Cl)cc2)c1=O 271668 US10065941, Compound I-160::US9732060, Compound I-160 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271668 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271668&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295428 378153494 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655500 COC(=O)C[C@@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3ncccc3F)cc2)n(Cc2ccc(Cl)cc2)c1=O 271670 US10065941, Compound I-161::US9732060, Compound I-161 P2X purinoceptor 3 Homo sapiens 10.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271670 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271670&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752180 378153496 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655501 C[C@H](CC(O)=O)n1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O 271672 US10065941, Compound I-162::US9732060, Compound I-162 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271672 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271672&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752190 378153498 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655502 C[C@H](CC(O)=O)n1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(F)n3)cc2)n(Cc2ccc(Cl)cc2)c1=O 271674 US10065941, Compound I-163::US9732060, Compound I-163 P2X purinoceptor 3 Homo sapiens 8.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271674 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271674&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752181 378153500 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655503 COc1cccnc1Oc1ccc(cc1)\N=c1/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C27H26ClN5O6/c1-27(2,23(34)35)16-33-25(36)31-24(32(26(33)37)15-17-6-8-18(28)9-7-17)30-19-10-12-20(13-11-19)39-22-21(38-3)5-4-14-29-22/h4-14H,15-16H2,1-3H3,(H,34,35)(H,30,31,36) OPZBTTMNFHGNRQ-UHFFFAOYSA-N 271676 US10065941, Compound I-164::US9732060, Compound I-164 P2X purinoceptor 3 Homo sapiens 29.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271676 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271676&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752198 378153502 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655504 C[C@H](CC(O)=O)n1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(F)cn3)cc2)n(Cc2ccc(Cl)cc2)c1=O 271678 US10065941, Compound I-165::US9732060, Compound I-165 P2X purinoceptor 3 Homo sapiens 15.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271678 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271678&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295429 378153504 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655505 C[C@H](CC(O)=O)n1c(=O)[nH]\c(=N/c2ccc(Oc3ncccc3F)cc2)n(Cc2ccc(Cl)cc2)c1=O 271680 US10065941, Compound I-166::US9732060, Compound I-166 P2X purinoceptor 3 Homo sapiens 13.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271680 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271680&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752295 378153506 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655506 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(F)cn3)cc2)n(Cc2ccc(cc2)C(F)F)c1=O)C(O)=O 271682 US10065941, Compound I-167::US9732060, Compound I-167 P2X purinoceptor 3 Homo sapiens 19.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271682 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271682&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752278 378153508 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655507 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(F)n3)cc2)n(Cc2ccc(cc2)C(F)F)c1=O)C(O)=O 271684 US10065941, Compound I-168::US9732060, Compound I-168 P2X purinoceptor 3 Homo sapiens 12.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271684 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271684&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752275 378153510 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655508 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ncccc3F)cc2)n(Cc2ccc(cc2)C(F)F)c1=O)C(O)=O 271686 US10065941, Compound I-169::US9732060, Compound I-169 P2X purinoceptor 3 Homo sapiens 21.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271686 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271686&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752286 378153512 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655509 CCOC(=O)[C@H]1C[C@@H](C1)n1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O 271688 US10065941, Compound I-170::US9732060, Compound I-170 P2X purinoceptor 3 Homo sapiens 15.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271688 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271688&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295430 378153514 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655510 CCOC(=O)[C@H]1C[C@H](C1)n1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O 271690 US10065941, Compound I-171::US9732060, Compound I-171 P2X purinoceptor 3 Homo sapiens 9.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271690 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271690&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295430 378153516 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655511 CCOC(=O)[C@H]1C[C@@H](C1)n1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(Cl)cn3)cc2)n(Cc2ccc(C)cc2)c1=O 271692 US10065941, Compound I-172::US9732060, Compound I-172 P2X purinoceptor 3 Homo sapiens 26.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271692 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271692&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752084 378153518 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655512 CCOC(=O)[C@H]1C[C@H](C1)n1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(Cl)cn3)cc2)n(Cc2ccc(C)cc2)c1=O 271694 US10065941, Compound I-173::US9732060, Compound I-173 P2X purinoceptor 3 Homo sapiens 8.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271694 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271694&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752084 378153520 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655513 OC(=O)[C@H]1C[C@@H](C1)n1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O 271696 US10065941, Compound I-174::US9732060, Compound I-174 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271696 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271696&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752081 378153522 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655514 OC(=O)[C@H]1C[C@H](C1)n1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O 271698 US10065941, Compound I-175::US9732060, Compound I-175 P2X purinoceptor 3 Homo sapiens 9.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271698 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271698&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752081 378153524 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655515 CCOC(=O)[C@H]1C[C@@H](C1)n1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(F)cn3)cc2)n(Cc2ccc(C)cc2)c1=O 271700 US10065941, Compound I-176::US9732060, Compound I-176 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271700 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271700&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752212 378153526 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655516 CCOC(=O)[C@H]1C[C@H](C1)n1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(F)cn3)cc2)n(Cc2ccc(C)cc2)c1=O 271702 US10065941, Compound I-177::US9732060, Compound I-177 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271702 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271702&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752212 378153528 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655517 Cc1ccc(Cn2c(=O)n([C@H]3C[C@@H](C3)C(O)=O)c(=O)[nH]\c2=N/c2ccc(Oc3ccc(Cl)cn3)cc2)cc1 271704 US10065941, Compound I-178::US9732060, Compound I-178 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271704 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271704&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295392 378153530 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655518 Cc1ccc(Cn2c(=O)n([C@@H]3C[C@@H](C3)C(O)=O)c(=O)[nH]\c2=N/c2ccc(Oc3ccc(Cl)cn3)cc2)cc1 271706 US10065941, Compound I-179::US9732060, Compound I-179 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271706 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271706&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295392 378153532 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655519 CCOC(O)[C@H]1C[C@@H](C1)n1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(Cc2ccc(C)cc2)c1=O 334458 US9732060, Compound I-180 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=334458 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=334458&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295431 384986618 C01707 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655520 CCOC(=O)[C@H]1C[C@H](C1)n1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(Cc2ccc(C)cc2)c1=O 271710 US10065941, Compound I-181::US9732060, Compound I-181 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271710 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271710&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752206 378153536 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655521 Cc1ccc(Cn2c(=O)n([C@H]3C[C@@H](C3)C(O)=O)c(=O)[nH]\c2=N/c2ccc(Oc3ccc(F)cn3)cc2)cc1 271712 US10065941, Compound I-182::US9732060, Compound I-182 P2X purinoceptor 3 Homo sapiens 8.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271712 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271712&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752224 378153538 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655522 Cc1ccc(Cn2c(=O)n([C@@H]3C[C@@H](C3)C(O)=O)c(=O)[nH]\c2=N/c2ccc(Oc3ccc(F)cn3)cc2)cc1 271714 US10065941, Compound I-183::US9732060, Compound I-183 P2X purinoceptor 3 Homo sapiens 12.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271714 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271714&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752224 378153540 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655523 Cc1ccc(Cn2c(=O)n([C@H]3C[C@@H](C3)C(O)=O)c(=O)[nH]\c2=N/c2ccc(Oc3ccccn3)cc2)cc1 271716 US10065941, Compound I-184::US9732060, Compound I-184 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271716 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271716&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752205 378153542 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655524 Cc1ccc(Cn2c(=O)n([C@@H]3C[C@@H](C3)C(O)=O)c(=O)[nH]\c2=N/c2ccc(Oc3ccccn3)cc2)cc1 271718 US10065941, Compound I-185::US9732060, Compound I-185 P2X purinoceptor 3 Homo sapiens 9.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271718 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271718&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752205 378153544 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655525 COC(=O)C[C@@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(Cc2ccc(C)cc2)c1=O 271720 US10065941, Compound I-186::US9732060, Compound I-186 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271720 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271720&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752191 378153546 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655526 C[C@H](CC(O)=O)n1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(Cc2ccc(C)cc2)c1=O 271722 US10065941, Compound I-187::US9732060, Compound I-187 P2X purinoceptor 3 Homo sapiens 8.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271722 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271722&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752182 378153548 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655527 COC(O)C[C@@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3ncccc3F)cc2)n(Cc2ccc(C)cc2)c1=O 334466 US9732060, Compound I-188 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=334466 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=334466&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295432 384986626 C01707 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655528 C[C@H](CC(O)=O)n1c(=O)[nH]\c(=N/c2ccc(Oc3ncccc3F)cc2)n(Cc2ccc(C)cc2)c1=O 271726 US10065941, Compound I-189::US9732060, Compound I-189 P2X purinoceptor 3 Homo sapiens 12.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271726 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271726&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752172 378153552 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655529 COC(O)C[C@@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(F)cn3)cc2)n(Cc2ccc(C)cc2)c1=O 334468 US9732060, Compound I-190 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=334468 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=334468&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295433 384986628 C01707 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655530 C[C@H](CC(O)=O)n1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(F)cn3)cc2)n(Cc2ccc(C)cc2)c1=O 271730 US10065941, Compound I-191::US9732060, Compound I-191 P2X purinoceptor 3 Homo sapiens 11.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271730 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271730&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752114 378153556 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655531 CCOC(=O)C1(Cn2c(=O)[nH]\c(=N/c3ccc(Oc4ccccn4)cc3)n(Cc3ccc(Cl)cc3)c2=O)CC1 InChI=1S/C28H26ClN5O5/c1-2-38-24(35)28(14-15-28)18-34-26(36)32-25(33(27(34)37)17-19-6-8-20(29)9-7-19)31-21-10-12-22(13-11-21)39-23-5-3-4-16-30-23/h3-13,16H,2,14-15,17-18H2,1H3,(H,31,32,36) YVTVATISFXSKSO-UHFFFAOYSA-N 271732 US10065941, Compound I-192::US9732060, Compound I-192 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271732 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271732&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752110 378153558 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655532 OC(=O)C1(Cn2c(=O)[nH]\c(=N/c3ccc(Oc4ccccn4)cc3)n(Cc3ccc(Cl)cc3)c2=O)CC1 InChI=1S/C26H22ClN5O5/c27-18-6-4-17(5-7-18)15-31-23(30-24(35)32(25(31)36)16-26(12-13-26)22(33)34)29-19-8-10-20(11-9-19)37-21-3-1-2-14-28-21/h1-11,14H,12-13,15-16H2,(H,33,34)(H,29,30,35) LYCIFQWBCYVZSS-UHFFFAOYSA-N 271734 US10065941, Compound I-193::US9732060, Compound I-193 P2X purinoceptor 3 Homo sapiens 8.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271734 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271734&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752111 378153560 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655533 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(Cc2ccc(cc2)C(F)F)c1=O 271736 US10065941, Compound I-194::US9732060, Compound I-194 P2X purinoceptor 3 Homo sapiens 12.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271736 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271736&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752112 378153562 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655534 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 271738 US10065941, Compound I-195::US9732060, Compound I-195 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271738 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271738&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752113 378153564 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655535 CC(C)(C)n1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(cn3)-c3cccc(c3)C(O)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C32H28ClN5O5/c1-32(2,3)38-30(41)36-29(37(31(38)42)19-20-7-10-24(33)11-8-20)35-25-12-14-26(15-13-25)43-27-16-9-23(18-34-27)21-5-4-6-22(17-21)28(39)40/h4-18H,19H2,1-3H3,(H,39,40)(H,35,36,41) MVOFXOLVQPEOON-UHFFFAOYSA-N 271651 US10065941, Compound R-001::US9732060, Compound R-001 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271651 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271651&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295463 378153477 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655536 COC(=O)c1cccc(c1)-c1ccc(Oc2ccc(cc2)\N=c2/[nH]c(=O)[nH]c(=O)n2Cc2ccc(Cl)cc2)nc1 InChI=1S/C29H22ClN5O5/c1-39-26(36)20-4-2-3-19(15-20)21-7-14-25(31-16-21)40-24-12-10-23(11-13-24)32-27-33-28(37)34-29(38)35(27)17-18-5-8-22(30)9-6-18/h2-16H,17H2,1H3,(H2,32,33,34,37,38) ODKZZHFIDIJWOL-UHFFFAOYSA-N 271653 US10065941, Compound R-002::US9732060, Compound R-002 P2X purinoceptor 3 Homo sapiens 363 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271653 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271653&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295464 378153479 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655537 OC(=O)c1cccc(c1)-c1ccc(Oc2ccc(cc2)\N=c2/[nH]c(=O)[nH]c(=O)n2Cc2ccc(Cl)cc2)nc1 InChI=1S/C28H20ClN5O5/c29-21-7-4-17(5-8-21)16-34-26(32-27(37)33-28(34)38)31-22-9-11-23(12-10-22)39-24-13-6-20(15-30-24)18-2-1-3-19(14-18)25(35)36/h1-15H,16H2,(H,35,36)(H2,31,32,33,37,38) FTUIUPQPRKNGCJ-UHFFFAOYSA-N 271655 US10065941, Compound R-003::US9732060, Compound R-003 P2X purinoceptor 3 Homo sapiens 4.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271655 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271655&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295465 378153481 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655538 COC(=O)c1ccc(NC(=O)c2cccc(Oc3ccc(cc3)\N=c3/[nH]c(=O)n(C)c(=O)n3C[C@H]3CC[C@H](C)CC3)n2)cc1 271657 US10065941, Compound R-004::US9732060, Compound R-004 P2X purinoceptor 3 Homo sapiens 123 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271657 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271657&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752363 378153483 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655539 CCn1c(=O)[nH]\c(=N/c2ccc(cc2)-c2ccc(cn2)C#N)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H19ClN6O2/c1-2-30-23(32)29-22(31(24(30)33)15-16-3-8-19(25)9-4-16)28-20-10-6-18(7-11-20)21-12-5-17(13-26)14-27-21/h3-12,14H,2,15H2,1H3,(H,28,29,32) PLQUOVWNAAKCCC-UHFFFAOYSA-N 271659 US10065941, Compound R-005::US9732060, Compound R-005 P2X purinoceptor 3 Homo sapiens 608 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271659 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271659&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295466 378153485 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655540 Cc1ccc(Cn2c(=O)n(C)c(=O)[nH]\c2=N/c2ccc(Oc3cccc(n3)C(=O)Nc3ccc(cc3)C(O)=O)cc2)cc1 InChI=1S/C31H26N6O6/c1-19-6-8-20(9-7-19)18-37-29(35-30(41)36(2)31(37)42)33-23-14-16-24(17-15-23)43-26-5-3-4-25(34-26)27(38)32-22-12-10-21(11-13-22)28(39)40/h3-17H,18H2,1-2H3,(H,32,38)(H,39,40)(H,33,35,41) ITOVZCOBVCJZQG-UHFFFAOYSA-N 334479 US9732060, Compound R-006 P2X purinoceptor 3 Homo sapiens 4.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=334479 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=334479&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295467 384986639 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655541 CCn1c(=O)nc(Nc2ccc3nc(oc3c2)C(C)C)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C22H22ClN5O3/c1-4-27-21(29)26-20(28(22(27)30)12-14-5-7-15(23)8-6-14)24-16-9-10-17-18(11-16)31-19(25-17)13(2)3/h5-11,13H,4,12H2,1-3H3,(H,24,26,29) VBMLVOYQNOZDNL-UHFFFAOYSA-N 271663 US10065941, Compound R-007::US9732060, Compound R-007 P2X purinoceptor 3 Homo sapiens 301 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271663 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271663&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 136213973 378153489 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655542 COc1cc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n([C@@H](C)[C@@H](C)C(O)=O)c(=O)n2Cc2ccc(Cl)cc2)ccn1 271665 US10065941, Compound R-009::US9732060, Compound R-009 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271665 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271665&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295469 378153491 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655543 COc1nccc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n([C@@H](C)[C@@H](C)C(O)=O)c(=O)n2Cc2ccc(Cl)cc2)n1 271667 US10065941, Compound R-010::US9732060, Compound R-010 P2X purinoceptor 3 Homo sapiens 10.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271667 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271667&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295470 378153493 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655544 CC(C)n1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(n3)C#N)c(Cl)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H20Cl2N6O3/c1-15(2)33-24(34)31-23(32(25(33)35)14-16-6-8-17(26)9-7-16)30-18-10-11-21(20(27)12-18)36-22-5-3-4-19(13-28)29-22/h3-12,15H,14H2,1-2H3,(H,30,31,34) RRJYLKBBXADXIX-UHFFFAOYSA-N 271669 US10065941, Compound R-011::US9732060, Compound R-011 P2X purinoceptor 3 Homo sapiens 49.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271669 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271669&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295471 378153495 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655545 CC(C)n1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(n3)C(O)=O)c(Cl)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H21Cl2N5O5/c1-14(2)32-24(35)30-23(31(25(32)36)13-15-6-8-16(26)9-7-15)28-17-10-11-20(18(27)12-17)37-21-5-3-4-19(29-21)22(33)34/h3-12,14H,13H2,1-2H3,(H,33,34)(H,28,30,35) QKWZGWJSVAKJEE-UHFFFAOYSA-N 271671 US10065941, Compound R-012::US9732060, Compound R-012 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271671 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271671&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295472 378153497 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655546 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cnc(Cl)cn3)cc2)n(Cc2ccc(Cl)cc2)c1=O 271673 US10065941, Compound R-013::US9732060, Compound R-013 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271673&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295473 378153499 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655547 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cnc(Cl)cn3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271675 US10065941, Compound R-014::US9732060, Compound R-014 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271675 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271675&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295474 378153501 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655548 CCOC(=O)c1cnc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(CC)c(=O)n2Cc2ccc(Cl)cc2)c(Cl)c1 InChI=1S/C26H23Cl2N5O5/c1-3-32-25(35)31-24(33(26(32)36)15-16-5-7-18(27)8-6-16)30-19-9-11-20(12-10-19)38-22-21(28)13-17(14-29-22)23(34)37-4-2/h5-14H,3-4,15H2,1-2H3,(H,30,31,35) WRUVNESKJUZMAL-UHFFFAOYSA-N 271677 US10065941, Compound R-015::US9732060, Compound R-015 P2X purinoceptor 3 Homo sapiens 104 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271677 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271677&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121280871 378153503 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655549 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ncc(cc3Cl)C(O)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H19Cl2N5O5/c1-2-30-23(34)29-22(31(24(30)35)13-14-3-5-16(25)6-4-14)28-17-7-9-18(10-8-17)36-20-19(26)11-15(12-27-20)21(32)33/h3-12H,2,13H2,1H3,(H,32,33)(H,28,29,34) APOGATSIIDPPRZ-UHFFFAOYSA-N 271679 US10065941, Compound R-016::US9732060, Compound R-016 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271679 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271679&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121280828 378153505 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655550 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cnccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O 271681 US10065941, Compound R-017::US9732060, Compound R-017 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271681 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271681&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295475 378153507 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655551 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cnccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H25ClN6O5/c1-26(2,22(34)37-3)16-33-24(35)31-23(32(25(33)36)15-17-4-6-18(27)7-5-17)30-19-8-10-20(11-9-19)38-21-14-28-12-13-29-21/h4-14H,15-16H2,1-3H3,(H,30,31,35) UIIMWNKGAHFXQR-UHFFFAOYSA-N 271683 US10065941, Compound R-018::US9732060, Compound R-018 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271683 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271683&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295476 378153509 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655552 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cnccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271685 US10065941, Compound R-019::US9732060, Compound R-019 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271685 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271685&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295477 378153511 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655553 CC(C)(Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cnccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O InChI=1S/C25H23ClN6O5/c1-25(2,21(33)34)15-32-23(35)30-22(31(24(32)36)14-16-3-5-17(26)6-4-16)29-18-7-9-19(10-8-18)37-20-13-27-11-12-28-20/h3-13H,14-15H2,1-2H3,(H,33,34)(H,29,30,35) DVJQMYXLYGAUNZ-UHFFFAOYSA-N 271687 US10065941, Compound R-020::US9732060, Compound R-020 P2X purinoceptor 3 Homo sapiens 13.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271687 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271687&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295478 378153513 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655554 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n([C@H]2C[C@@H](C2)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 271689 US10065941, Compound R-021::US9732060, Compound R-021 P2X purinoceptor 3 Homo sapiens 15.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271689 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271689&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295479 378153515 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655555 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n([C@@H]2C[C@@H](C2)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 271691 US10065941, Compound R-022::US9732060, Compound R-022 P2X purinoceptor 3 Homo sapiens 12.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271691 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271691&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295479 378153517 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655556 CCc1oc2ccc(cc2c1C)\N=c1/[nH]c(=O)n([C@H]2C[C@@H](C2)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 271693 US10065941, Compound R-023::US9732060, Compound R-023 P2X purinoceptor 3 Homo sapiens 21.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271693 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271693&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295480 378153519 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655557 CCc1oc2ccc(cc2c1C)\N=c1/[nH]c(=O)n([C@@H]2C[C@@H](C2)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 271695 US10065941, Compound R-024::US9732060, Compound R-024 P2X purinoceptor 3 Homo sapiens 18.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271695 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271695&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295480 378153521 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655558 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cnc(Cl)cn3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H24Cl2N6O5/c1-26(2,22(35)38-3)15-34-24(36)32-23(33(25(34)37)14-16-4-6-17(27)7-5-16)31-18-8-10-19(11-9-18)39-21-13-29-20(28)12-30-21/h4-13H,14-15H2,1-3H3,(H,31,32,36) CYARJWMGFCOFND-UHFFFAOYSA-N 271697 US10065941, Compound R-025::US9732060, Compound R-025 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271697 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271697&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295481 378153523 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655559 COC(=O)C(C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(OC(F)F)cn3)cc2)n(Cc2ccc(Cl)cc2)c1=O 271699 US10065941, Compound R-026::US9732060, Compound R-026 P2X purinoceptor 3 Homo sapiens 8.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271699 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271699&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295484 378153525 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655560 CC(C)(Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cnc(Cl)cn3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O InChI=1S/C25H22Cl2N6O5/c1-25(2,21(34)35)14-33-23(36)31-22(32(24(33)37)13-15-3-5-16(26)6-4-15)30-17-7-9-18(10-8-17)38-20-12-28-19(27)11-29-20/h3-12H,13-14H2,1-2H3,(H,34,35)(H,30,31,36) AYWPYOKNYIKNFU-UHFFFAOYSA-N 271701 US10065941, Compound R-027::US9732060, Compound R-027 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271701 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271701&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295483 378153527 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655561 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(nn3)C(F)(F)F)cc2)n(Cc2ccc(Cl)cc2)c1=O 271703 US10065941, Compound R-028::US9732060, Compound R-028 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271703 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271703&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295482 378153529 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655562 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(nn3)C(F)(F)F)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C27H24ClF3N6O5/c1-26(2,22(38)41-3)15-37-24(39)33-23(36(25(37)40)14-16-4-6-17(28)7-5-16)32-18-8-10-19(11-9-18)42-21-13-12-20(34-35-21)27(29,30)31/h4-13H,14-15H2,1-3H3,(H,32,33,39) HFWYOVIAPYRHST-UHFFFAOYSA-N 271705 US10065941, Compound R-029::US9732060, Compound R-029 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271705 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271705&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295485 378153531 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655563 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(nn3)C(F)(F)F)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271707 US10065941, Compound R-030::US9732060, Compound R-030 P2X purinoceptor 3 Homo sapiens 8.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271707 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271707&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295486 378153533 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655564 CC(C)(Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(nn3)C(F)(F)F)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O InChI=1S/C26H22ClF3N6O5/c1-25(2,21(37)38)14-36-23(39)32-22(35(24(36)40)13-15-3-5-16(27)6-4-15)31-17-7-9-18(10-8-17)41-20-12-11-19(33-34-20)26(28,29)30/h3-12H,13-14H2,1-2H3,(H,37,38)(H,31,32,39) UDUPYIQZPNAMKN-UHFFFAOYSA-N 271709 US10065941, Compound R-031::US9732060, Compound R-031 P2X purinoceptor 3 Homo sapiens 12.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271709 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271709&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295487 378153535 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655565 COc1cc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n2Cc2ccc(Cl)cc2)ccn1 271711 US10065941, Compound R-032::US9732060, Compound R-032 P2X purinoceptor 3 Homo sapiens 4.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271711 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271711&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295489 378153537 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655566 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cccnn3)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O 271713 US10065941, Compound R-033::US9732060, Compound R-033 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271713 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271713&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295488 378153539 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655567 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cccnn3)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H24ClFN6O5/c1-26(2,22(35)38-3)15-34-24(36)31-23(33(25(34)37)14-16-6-8-17(27)9-7-16)30-18-10-11-20(19(28)13-18)39-21-5-4-12-29-32-21/h4-13H,14-15H2,1-3H3,(H,30,31,36) ZCNBNHGEJQGTCD-UHFFFAOYSA-N 271715 US10065941, Compound R-034::US9732060, Compound R-034 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271715 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271715&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295491 378153541 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655568 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cnc(cn3)C(F)(F)F)cc2)n(Cc2ccc(Cl)cc2)c1=O 271717 US10065941, Compound R-035::US9732060, Compound R-035 P2X purinoceptor 3 Homo sapiens 8.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271717 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271717&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295490 378153543 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655569 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cnc(cn3)C(F)(F)F)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C27H24ClF3N6O5/c1-26(2,22(38)41-3)15-37-24(39)35-23(36(25(37)40)14-16-4-6-17(28)7-5-16)34-18-8-10-19(11-9-18)42-21-13-32-20(12-33-21)27(29,30)31/h4-13H,14-15H2,1-3H3,(H,34,35,39) ICJNQKKAAKFFRD-UHFFFAOYSA-N 271719 US10065941, Compound R-036::US9732060, Compound R-036 P2X purinoceptor 3 Homo sapiens 11.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271719 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271719&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295492 378153545 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655570 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cccnn3)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271721 US10065941, Compound R-037::US9732060, Compound R-037 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271721 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271721&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295494 378153547 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655571 CC(C)(Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cccnn3)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O InChI=1S/C25H22ClFN6O5/c1-25(2,21(34)35)14-33-23(36)30-22(32(24(33)37)13-15-5-7-16(26)8-6-15)29-17-9-10-19(18(27)12-17)38-20-4-3-11-28-31-20/h3-12H,13-14H2,1-2H3,(H,34,35)(H,29,30,36) BLIMNJQAPWJVRX-UHFFFAOYSA-N 271723 US10065941, Compound R-038::US9732060, Compound R-038 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271723 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271723&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295493 378153549 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655572 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cnc(cn3)C(F)(F)F)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271725 US10065941, Compound R-039::US9732060, Compound R-039 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271725 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271725&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295495 378153551 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655573 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cc(F)nc(F)c3)cc2)n(Cc2ccc(Cl)cc2)c1=O 271727 US10065941, Compound R-040::US9732060, Compound R-040 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271727 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271727&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295496 378153553 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655574 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cc(F)nc(F)c3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C27H24ClF2N5O5/c1-27(2,23(36)39-3)15-35-25(37)33-24(34(26(35)38)14-16-4-6-17(28)7-5-16)31-18-8-10-19(11-9-18)40-20-12-21(29)32-22(30)13-20/h4-13H,14-15H2,1-3H3,(H,31,33,37) KVDCRNHHUBBWBR-UHFFFAOYSA-N 271729 US10065941, Compound R-041::US9732060, Compound R-041 P2X purinoceptor 3 Homo sapiens 11.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271729 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271729&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295497 378153555 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655575 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccnc(C)n3)cc2)n(Cc2ccc(Cl)cc2)c1=O 271731 US10065941, Compound R-042::US9732060, Compound R-042 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271731 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271731&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295498 378153557 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655576 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccnc(C)n3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C27H27ClN6O5/c1-17-29-14-13-22(30-17)39-21-11-9-20(10-12-21)31-24-32-25(36)34(16-27(2,3)23(35)38-4)26(37)33(24)15-18-5-7-19(28)8-6-18/h5-14H,15-16H2,1-4H3,(H,31,32,36) PDDLXXRDCRKPGS-UHFFFAOYSA-N 271733 US10065941, Compound R-043::US9732060, Compound R-043 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271733 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271733&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295499 378153559 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655577 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccnc(C)n3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271735 US10065941, Compound R-044::US9732060, Compound R-044 P2X purinoceptor 3 Homo sapiens 10.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271735 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271735&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295500 378153561 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655578 Cc1nccc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n2Cc2ccc(Cl)cc2)n1 InChI=1S/C26H25ClN6O5/c1-16-28-13-12-21(29-16)38-20-10-8-19(9-11-20)30-23-31-24(36)33(15-26(2,3)22(34)35)25(37)32(23)14-17-4-6-18(27)7-5-17/h4-13H,14-15H2,1-3H3,(H,34,35)(H,30,31,36) ZAEYTCAZPLVGBC-UHFFFAOYSA-N 271737 US10065941, Compound R-045::US9732060, Compound R-045 P2X purinoceptor 3 Homo sapiens 14.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271737 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271737&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295501 378153563 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655579 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cc(Cl)ncn3)cc2)n(Cc2ccc(Cl)cc2)c1=O 271739 US10065941, Compound R-046::US9732060, Compound R-046 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271739 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271739&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295502 378153565 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655580 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cc(Cl)ncn3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H24Cl2N6O5/c1-26(2,22(35)38-3)14-34-24(36)32-23(33(25(34)37)13-16-4-6-17(27)7-5-16)31-18-8-10-19(11-9-18)39-21-12-20(28)29-15-30-21/h4-12,15H,13-14H2,1-3H3,(H,31,32,36) JWUQBNMBSHZLHT-UHFFFAOYSA-N 271740 US10065941, Compound R-047::US9732060, Compound R-047 P2X purinoceptor 3 Homo sapiens 9.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271740 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271740&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295503 378153566 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655581 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cnccn3)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O 271741 US10065941, Compound R-048::US9732060, Compound R-048 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271741 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271741&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295504 378153567 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655582 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cnccn3)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H24ClFN6O5/c1-26(2,22(35)38-3)15-34-24(36)32-23(33(25(34)37)14-16-4-6-17(27)7-5-16)31-18-8-9-20(19(28)12-18)39-21-13-29-10-11-30-21/h4-13H,14-15H2,1-3H3,(H,31,32,36) ZBVNZASTUVAISF-UHFFFAOYSA-N 271742 US10065941, Compound R-049::US9732060, Compound R-049 P2X purinoceptor 3 Homo sapiens 8.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271742 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271742&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295505 378153568 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655583 COc1cc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n2Cc2ccc(Cl)cc2)ncn1 271743 US10065941, Compound R-050::US9732060, Compound R-050 P2X purinoceptor 3 Homo sapiens 14.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271743 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271743&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752102 378153569 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655584 CCOC(=O)c1cnc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(CC)c(=O)n2Cc2ccc(Cl)cc2)cc1Cl InChI=1S/C26H23Cl2N5O5/c1-3-32-25(35)31-24(33(26(32)36)15-16-5-7-17(27)8-6-16)30-18-9-11-19(12-10-18)38-22-13-21(28)20(14-29-22)23(34)37-4-2/h5-14H,3-4,15H2,1-2H3,(H,30,31,35) RWGMLUJYBSFWMB-UHFFFAOYSA-N 271744 US10065941, Compound R-053::US9732060, Compound R-053 P2X purinoceptor 3 Homo sapiens 52.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271744 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271744&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295507 378153570 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655585 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3cc(Cl)c(cn3)C(O)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H19Cl2N5O5/c1-2-30-23(34)29-22(31(24(30)35)13-14-3-5-15(25)6-4-14)28-16-7-9-17(10-8-16)36-20-11-19(26)18(12-27-20)21(32)33/h3-12H,2,13H2,1H3,(H,32,33)(H,28,29,34) IURJIBYGKPLKIX-UHFFFAOYSA-N 271745 US10065941, Compound R-054::US9732060, Compound R-054 P2X purinoceptor 3 Homo sapiens 26.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271745 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271745&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295508 378153571 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655586 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cnccn3)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271746 US10065941, Compound R-055::US9732060, Compound R-055 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271746 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271746&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295509 378153572 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655587 CC(C)(Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cnccn3)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O InChI=1S/C25H22ClFN6O5/c1-25(2,21(34)35)14-33-23(36)31-22(32(24(33)37)13-15-3-5-16(26)6-4-15)30-17-7-8-19(18(27)11-17)38-20-12-28-9-10-29-20/h3-12H,13-14H2,1-2H3,(H,34,35)(H,30,31,36) ORCXKNLJBSZIKW-UHFFFAOYSA-N 271747 US10065941, Compound R-056::US9732060, Compound R-056 P2X purinoceptor 3 Homo sapiens 10.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271747 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271747&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295510 378153573 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655588 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cc(F)nc(F)c3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271748 US10065941, Compound R-057::US9732060, Compound R-057 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271748 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271748&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295511 378153574 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655589 COc1cc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n2Cc2ccc(Cl)cc2)cc(F)n1 271749 US10065941, Compound R-058::US9732060, Compound R-058 P2X purinoceptor 3 Homo sapiens 4.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271749 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271749&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295512 378153575 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655590 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ncccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O 271750 US10065941, Compound R-059::US9732060, Compound R-059 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271750 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271750&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295513 378153576 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655591 CC(C)(Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ncccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O InChI=1S/C25H23ClN6O5/c1-25(2,20(33)34)15-32-23(35)30-21(31(24(32)36)14-16-4-6-17(26)7-5-16)29-18-8-10-19(11-9-18)37-22-27-12-3-13-28-22/h3-13H,14-15H2,1-2H3,(H,33,34)(H,29,30,35) PRCLIANUHAPGBF-UHFFFAOYSA-N 271751 US10065941, Compound R-060::US9732060, Compound R-060 P2X purinoceptor 3 Homo sapiens 16.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271751 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271751&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295514 378153577 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655592 COc1nccc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n2Cc2ccc(Cl)cc2)n1 271752 US10065941, Compound R-061::US9732060, Compound R-061 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271752 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271752&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295516 378153578 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655593 CCOC(=O)[C@@H]1C[C@@H](C1)Oc1ccc(cc1)\N=c1/[nH]c(=O)n(CC)c(=O)n1Cc1ccc(Cl)cc1 271753 US10065941, Compound R-062::US9732060, Compound R-062 P2X purinoceptor 3 Homo sapiens 318 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271753 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271753&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295515 378153579 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655594 CCn1c(=O)[nH]\c(=N/c2ccc(O[C@H]3C[C@H](C3)C(O)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O 271754 US10065941, Compound R-063::US9732060, Compound R-063 P2X purinoceptor 3 Homo sapiens 456 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271754 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271754&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295517 378153580 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655595 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(C(=O)OC)c(Cl)n3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H21Cl2N5O5/c1-3-31-24(34)30-23(32(25(31)35)14-15-4-6-16(26)7-5-15)28-17-8-10-18(11-9-17)37-20-13-12-19(21(27)29-20)22(33)36-2/h4-13H,3,14H2,1-2H3,(H,28,30,34) BWPMVTKXOZPSEZ-UHFFFAOYSA-N 271755 US10065941, Compound R-064::US9732060, Compound R-064 P2X purinoceptor 3 Homo sapiens 12.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271755 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271755&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295519 378153581 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655596 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(C(O)=O)c(Cl)n3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H19Cl2N5O5/c1-2-30-23(34)29-22(31(24(30)35)13-14-3-5-15(25)6-4-14)27-16-7-9-17(10-8-16)36-19-12-11-18(21(32)33)20(26)28-19/h3-12H,2,13H2,1H3,(H,32,33)(H,27,29,34) HLESPNWKKHPTSG-UHFFFAOYSA-N 271756 US10065941, Compound R-066::US9732060, Compound R-066 P2X purinoceptor 3 Homo sapiens 58.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271756 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271756&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295518 378153582 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655597 CCc1[nH]c2ccc(cc2c1C)\N=c1/[nH]c(=O)n(C[C@H](C)C(=O)OC)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C26H26ClN5O4/c1-5-21-16(3)20-12-19(10-11-22(20)29-21)28-24-30-25(34)32(13-15(2)23(33)36-4)26(35)31(24)14-17-6-8-18(27)9-7-17/h6-12,15H,5,13-14H2,1-4H3/b28-19-/t15-/m0/s1 KHURNGCGIUDCAN-ZRAJOVRMSA-N 271757 US10065941, Compound R-068::US9732060, Compound R-068 P2X purinoceptor 3 Homo sapiens 40.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271757 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271757&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295520 378153583 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655598 CCc1[nH]c2ccc(cc2c1C)\N=c1/[nH]c(=O)n(CC(C)(C)C(=O)OC)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C27H30ClN5O4/c1-6-21-16(2)20-13-19(11-12-22(20)30-21)29-24-31-25(35)33(15-27(3,4)23(34)37-5)26(36)32(24)14-17-7-9-18(28)10-8-17/h7-13,30H,6,14-15H2,1-5H3,(H,29,31,35) LOFXMTHXCPJZPB-UHFFFAOYSA-N 271758 US10065941, Compound R-069::US9732060, Compound R-069 P2X purinoceptor 3 Homo sapiens 51.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271758 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271758&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295521 378153584 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655599 CC(C)(Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cc(F)nc(F)c3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O InChI=1S/C26H22ClF2N5O5/c1-26(2,22(35)36)14-34-24(37)32-23(33(25(34)38)13-15-3-5-16(27)6-4-15)30-17-7-9-18(10-8-17)39-19-11-20(28)31-21(29)12-19/h3-12H,13-14H2,1-2H3,(H,35,36)(H,30,32,37) BDVTWUFYGYQEGN-UHFFFAOYSA-N 271759 US10065941, Compound R-070::US9732060, Compound R-070 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271759 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271759&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295522 378153585 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655600 COc1cc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n2Cc2ccc(Cl)cc2)cc(F)n1 InChI=1S/C27H25ClFN5O6/c1-27(2,23(35)36)15-34-25(37)32-24(33(26(34)38)14-16-4-6-17(28)7-5-16)30-18-8-10-19(11-9-18)40-20-12-21(29)31-22(13-20)39-3/h4-13H,14-15H2,1-3H3,(H,35,36)(H,30,32,37) YIOQHMQYRLHCOW-UHFFFAOYSA-N 271760 US10065941, Compound R-071::US9732060, Compound R-071 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271760 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271760&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295523 378153586 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655601 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(OC3CCC3)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O 271761 US10065941, Compound R-072::US9732060, Compound R-072 P2X purinoceptor 3 Homo sapiens 16.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271761 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271761&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752298 378153587 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655602 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(OC3CCC3)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H28ClFN4O5/c1-26(2,22(33)36-3)15-32-24(34)30-23(31(25(32)35)14-16-7-9-17(27)10-8-16)29-18-11-12-21(20(28)13-18)37-19-5-4-6-19/h7-13,19H,4-6,14-15H2,1-3H3,(H,29,30,34) MRIYDBTXGOVCOP-UHFFFAOYSA-N 271762 US10065941, Compound R-073::US9732060, Compound R-073 P2X purinoceptor 3 Homo sapiens 31.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271762 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271762&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752294 378153588 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655603 CCc1[nH]c2ccc(cc2c1C)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C25H24ClN5O4/c1-4-20-15(3)19-11-18(9-10-21(19)28-20)27-23-29-24(34)31(12-14(2)22(32)33)25(35)30(23)13-16-5-7-17(26)8-6-16/h5-11,14H,4,12-13H2,1-3H3,(H,32,33)/b27-18-/t14-/m0/s1 STZAOFBEQZCXID-APVWPMNASA-N 271763 US10065941, Compound R-074::US9732060, Compound R-074 P2X purinoceptor 3 Homo sapiens 13.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271763 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271763&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295524 378153589 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655604 CCc1[nH]c2ccc(cc2c1C)\N=c1/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C26H28ClN5O4/c1-5-20-15(2)19-12-18(10-11-21(19)29-20)28-23-30-24(35)32(14-26(3,4)22(33)34)25(36)31(23)13-16-6-8-17(27)9-7-16/h6-12,29H,5,13-14H2,1-4H3,(H,33,34)(H,28,30,35) KYBRPBCGLDQTLV-UHFFFAOYSA-N 271764 US10065941, Compound R-075::US9732060, Compound R-075 P2X purinoceptor 3 Homo sapiens 13.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271764 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271764&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295532 378153590 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655605 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(OC3CCC3)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271765 US10065941, Compound R-076::US9732060, Compound R-076 P2X purinoceptor 3 Homo sapiens 13.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271765 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271765&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295525 378153591 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655606 CC(C)(Cn1c(=O)[nH]\c(=N/c2ccc(OC3CCC3)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O InChI=1S/C25H26ClFN4O5/c1-25(2,21(32)33)14-31-23(34)29-22(30(24(31)35)13-15-6-8-16(26)9-7-15)28-17-10-11-20(19(27)12-17)36-18-4-3-5-18/h6-12,18H,3-5,13-14H2,1-2H3,(H,32,33)(H,28,29,34) IIQSIVMLMRUNOP-UHFFFAOYSA-N 271766 US10065941, Compound R-077::US9732060, Compound R-077 P2X purinoceptor 3 Homo sapiens 24.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271766 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271766&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295526 378153592 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655607 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ncccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271767 US10065941, Compound R-078::US9732060, Compound R-078 P2X purinoceptor 3 Homo sapiens 10.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271767 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271767&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295528 378153593 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655608 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cncc(Cl)c3)cc2)n(Cc2ccc(Cl)cc2)c1=O 271768 US10065941, Compound R-079::US9732060, Compound R-079 P2X purinoceptor 3 Homo sapiens 11.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271768 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271768&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295527 378153594 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655609 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cncc(Cl)c3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C27H25Cl2N5O5/c1-27(2,23(35)38-3)16-34-25(36)32-24(33(26(34)37)15-17-4-6-18(28)7-5-17)31-20-8-10-21(11-9-20)39-22-12-19(29)13-30-14-22/h4-14H,15-16H2,1-3H3,(H,31,32,36) HGUDAHIKBGCKSI-UHFFFAOYSA-N 271769 US10065941, Compound R-080::US9732060, Compound R-080 P2X purinoceptor 3 Homo sapiens 13.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271769 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271769&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295538 378153595 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655610 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cncc(Cl)c3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271770 US10065941, Compound R-081::US9732060, Compound R-081 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271770 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271770&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295533 378153596 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655611 CC(C)(Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cncc(Cl)c3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O InChI=1S/C26H23Cl2N5O5/c1-26(2,22(34)35)15-33-24(36)31-23(32(25(33)37)14-16-3-5-17(27)6-4-16)30-19-7-9-20(10-8-19)38-21-11-18(28)12-29-13-21/h3-13H,14-15H2,1-2H3,(H,34,35)(H,30,31,36) ZWEGJKPZSTUVMJ-UHFFFAOYSA-N 271771 US10065941, Compound R-082::US9732060, Compound R-082 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271771 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271771&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295529 378153597 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655612 OCC1(Cn2c(=O)[nH]\c(=N/c3ccc(Oc4ncccc4F)cc3)n(Cc3ccc(Cl)cc3)c2=O)COC1 InChI=1S/C26H23ClFN5O5/c27-18-5-3-17(4-6-18)12-32-23(31-24(35)33(25(32)36)13-26(14-34)15-37-16-26)30-19-7-9-20(10-8-19)38-22-21(28)2-1-11-29-22/h1-11,34H,12-16H2,(H,30,31,35) FCJYWKKJQAQIJE-UHFFFAOYSA-N 271772 US10065941, Compound R-083::US9732060, Compound R-083 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271772 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271772&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295530 378153598 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655613 OCC1(Cn2c(=O)[nH]\c(=N/c3ccc(Oc4ccc(F)cn4)cc3)n(Cc3ccc(Cl)cc3)c2=O)COC1 InChI=1S/C26H23ClFN5O5/c27-18-3-1-17(2-4-18)12-32-23(31-24(35)33(25(32)36)13-26(14-34)15-37-16-26)30-20-6-8-21(9-7-20)38-22-10-5-19(28)11-29-22/h1-11,34H,12-16H2,(H,30,31,35) CMKXPIWSJLUWST-UHFFFAOYSA-N 271773 US10065941, Compound R-084::US9732060, Compound R-084 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271773 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271773&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295531 378153599 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655614 COc1ccc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n2Cc2ccc(Cl)cc2)nn1 271774 US10065941, Compound R-085::US9732060, Compound R-085 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271774 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271774&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295534 378153600 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655615 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccnc(Cl)c3)cc2)n(Cc2ccc(Cl)cc2)c1=O 271775 US10065941, Compound R-086::US9732060, Compound R-086 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271775 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271775&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295539 378153601 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655616 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccnc(Cl)c3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C27H25Cl2N5O5/c1-27(2,23(35)38-3)16-34-25(36)32-24(33(26(34)37)15-17-4-6-18(28)7-5-17)31-19-8-10-20(11-9-19)39-21-12-13-30-22(29)14-21/h4-14H,15-16H2,1-3H3,(H,31,32,36) ZNXIRIAVXRMFJG-UHFFFAOYSA-N 271776 US10065941, Compound R-087::US9732060, Compound R-087 P2X purinoceptor 3 Homo sapiens 12.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271776 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271776&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295535 378153602 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655617 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccnc(Cl)c3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271777 US10065941, Compound R-088::US9732060, Compound R-088 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271777 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271777&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295542 378153603 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655618 CC(C)(Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccnc(Cl)c3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O InChI=1S/C26H23Cl2N5O5/c1-26(2,22(34)35)15-33-24(36)31-23(32(25(33)37)14-16-3-5-17(27)6-4-16)30-18-7-9-19(10-8-18)38-20-11-12-29-21(28)13-20/h3-13H,14-15H2,1-2H3,(H,34,35)(H,30,31,36) GQLVLAMFWPKKMW-UHFFFAOYSA-N 271778 US10065941, Compound R-089::US9732060, Compound R-089 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271778 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271778&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295536 378153604 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655619 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(O[C@H](C)C(F)(F)F)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O 271779 US10065941, Compound R-090::US9732060, Compound R-090 P2X purinoceptor 3 Homo sapiens 70.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271779 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271779&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295537 378153605 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655620 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(O[C@H](C)C(F)(F)F)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O 271780 US10065941, Compound R-091::US9732060, Compound R-091 P2X purinoceptor 3 Homo sapiens 108 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271780 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271780&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295544 378153606 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655621 CC(C)(Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cc(Cl)ncn3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O InChI=1S/C25H22Cl2N6O5/c1-25(2,21(34)35)13-33-23(36)31-22(32(24(33)37)12-15-3-5-16(26)6-4-15)30-17-7-9-18(10-8-17)38-20-11-19(27)28-14-29-20/h3-11,14H,12-13H2,1-2H3,(H,34,35)(H,30,31,36) YEDBGRDFLMHAGG-UHFFFAOYSA-N 271781 US10065941, Compound R-092::US9732060, Compound R-092 P2X purinoceptor 3 Homo sapiens 10.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271781 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271781&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295541 378153607 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655622 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(O[C@H](C)C(F)(F)F)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271782 US10065941, Compound R-093::US9732060, Compound R-093 P2X purinoceptor 3 Homo sapiens 13.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271782 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271782&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295543 378153608 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655623 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(O[C@H](C)C(F)(F)F)c(O[C@H](C)C(F)(F)F)c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271783 US10065941, Compound R-094::US9732060, Compound R-094 P2X purinoceptor 3 Homo sapiens 29.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271783 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271783&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295546 378153609 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655624 C[C@@H](Oc1ccc(cc1F)\N=c1/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1)C(F)(F)F 271784 US10065941, Compound R-095::US9732060, Compound R-095 P2X purinoceptor 3 Homo sapiens 45.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271784 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271784&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295540 378153610 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655625 C[C@@H](Oc1ccc(cc1O[C@H](C)C(F)(F)F)\N=c1/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1)C(F)(F)F 271785 US10065941, Compound R-096::US9732060, Compound R-096 P2X purinoceptor 3 Homo sapiens 156 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271785 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271785&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295547 378153611 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655626 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(O[C@H](C)C(F)(F)F)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O 271786 US10065941, Compound R-097::US9732060, Compound R-097 P2X purinoceptor 3 Homo sapiens 212 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271786 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271786&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295545 378153612 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655627 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(O[C@H](C)C(F)(F)F)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271787 US10065941, Compound R-098::US9732060, Compound R-098 P2X purinoceptor 3 Homo sapiens 80.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271787 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271787&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295548 378153613 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655628 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccnc(c3)C#N)cc2)n(Cc2ccc(Cl)cc2)c1=O 271788 US10065941, Compound R-099::US9732060, Compound R-099 P2X purinoceptor 3 Homo sapiens 4.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271788 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271788&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295549 378153614 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655629 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccnc(c3)C#N)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C28H25ClN6O5/c1-28(2,24(36)39-3)17-35-26(37)33-25(34(27(35)38)16-18-4-6-19(29)7-5-18)32-20-8-10-22(11-9-20)40-23-12-13-31-21(14-23)15-30/h4-14H,16-17H2,1-3H3,(H,32,33,37) KBPOYCAUDGOMJM-UHFFFAOYSA-N 271789 US10065941, Compound R-100::US9732060, Compound R-100 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271789 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271789&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295550 378153615 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655630 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(N3CCOCC3)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O 271790 US10065941, Compound R-101::US9732060, Compound R-101 P2X purinoceptor 3 Homo sapiens 201 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271790 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271790&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752381 378153616 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655631 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(N3CCOCC3)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C27H32ClN5O5/c1-18-15-21(9-10-22(18)31-11-13-38-14-12-31)29-24-30-25(35)33(17-27(2,3)23(34)37-4)26(36)32(24)16-19-5-7-20(28)8-6-19/h5-10,15H,11-14,16-17H2,1-4H3,(H,29,30,35) IBAISRLJYOJERF-UHFFFAOYSA-N 271791 US10065941, Compound R-102::US9732060, Compound R-102 P2X purinoceptor 3 Homo sapiens 100.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271791 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271791&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752359 378153617 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655632 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccnc(c3)C(O)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C28H26ClN5O7/c1-28(2,24(37)40-3)16-34-26(38)32-25(33(27(34)39)15-17-4-6-18(29)7-5-17)31-19-8-10-20(11-9-19)41-21-12-13-30-22(14-21)23(35)36/h4-14H,15-16H2,1-3H3,(H,35,36)(H,31,32,38) SCZCBRJAEQZYSI-UHFFFAOYSA-N 271792 US10065941, Compound R-105::US9732060, Compound R-105 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271792 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271792&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295551 378153618 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655633 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(N3CCOCC3)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O 271793 US10065941, Compound R-106::US9732060, Compound R-106 P2X purinoceptor 3 Homo sapiens 379 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271793 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271793&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752214 378153619 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655634 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(N3CCOCC3)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H29ClFN5O5/c1-26(2,22(34)37-3)16-33-24(35)30-23(32(25(33)36)15-17-4-6-18(27)7-5-17)29-19-8-9-21(20(28)14-19)31-10-12-38-13-11-31/h4-9,14H,10-13,15-16H2,1-3H3,(H,29,30,35) QUWOAYIUOXHNOP-UHFFFAOYSA-N 271794 US10065941, Compound R-107::US9732060, Compound R-107 P2X purinoceptor 3 Homo sapiens 217 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271794 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271794&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752215 378153620 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655635 CC(C)(Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccnc(c3)C#N)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O InChI=1S/C27H23ClN6O5/c1-27(2,23(35)36)16-34-25(37)32-24(33(26(34)38)15-17-3-5-18(28)6-4-17)31-19-7-9-21(10-8-19)39-22-11-12-30-20(13-22)14-29/h3-13H,15-16H2,1-2H3,(H,35,36)(H,31,32,37) ZIUOCROSMYZZSW-UHFFFAOYSA-N 271795 US10065941, Compound R-108::US9732060, Compound R-108 P2X purinoceptor 3 Homo sapiens 8.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271795 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271795&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295552 378153621 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655636 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cnccn3)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O 271796 US10065941, Compound R-111::US9732060, Compound R-111 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271796 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271796&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295559 378153622 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655637 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3noc(C)n3)cc2)n(Cc2ccc(Cl)cc2)c1=O 271797 US10065941, Compound R-112::US9732060, Compound R-112 P2X purinoceptor 3 Homo sapiens 17.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271797 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271797&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295553 378153623 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655638 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3noc(C)n3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H25ClN6O6/c1-15-27-22(30-38-15)37-19-11-9-18(10-12-19)28-21-29-23(34)32(14-25(2,3)20(33)36-4)24(35)31(21)13-16-5-7-17(26)8-6-16/h5-12H,13-14H2,1-4H3,(H,28,29,34) ZQOIFPNWZJAAMK-UHFFFAOYSA-N 271798 US10065941, Compound R-113::US9732060, Compound R-113 P2X purinoceptor 3 Homo sapiens 13.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271798 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271798&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295560 378153624 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655639 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3noc(C)n3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271799 US10065941, Compound R-114::US9732060, Compound R-114 P2X purinoceptor 3 Homo sapiens 39.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271799 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271799&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295554 378153625 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655640 Cc1nc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n2Cc2ccc(Cl)cc2)no1 InChI=1S/C24H23ClN6O6/c1-14-26-21(29-37-14)36-18-10-8-17(9-11-18)27-20-28-22(34)31(13-24(2,3)19(32)33)23(35)30(20)12-15-4-6-16(25)7-5-15/h4-11H,12-13H2,1-3H3,(H,32,33)(H,27,28,34) UJLMUALVXSNBRM-UHFFFAOYSA-N 271800 US10065941, Compound R-115::US9732060, Compound R-115 P2X purinoceptor 3 Homo sapiens 65.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271800 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271800&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295568 378153626 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655641 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cncc(F)c3)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271801 US10065941, Compound R-116::US9732060, Compound R-116 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271801 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271801&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295555 378153627 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655642 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cncc(F)c3)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271802 US10065941, Compound R-117::US9732060, Compound R-117 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271802 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271802&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295569 378153628 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655643 Cc1cc(ccc1Oc1cncc(F)c1)\N=c1/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C27H25ClFN5O5/c1-16-10-20(8-9-22(16)39-21-11-19(29)12-30-13-21)31-24-32-25(37)34(15-27(2,3)23(35)36)26(38)33(24)14-17-4-6-18(28)7-5-17/h4-13H,14-15H2,1-3H3,(H,35,36)(H,31,32,37) WZHWWUIQQFQHAG-UHFFFAOYSA-N 271803 US10065941, Compound R-118::US9732060, Compound R-118 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271803 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271803&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295561 378153629 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655644 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cccnn3)cc2)n(Cc2ccc(Cl)cc2)c1=O 271804 US10065941, Compound R-119::US9732060, Compound R-119 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271804 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271804&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295557 378153630 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655645 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cccnn3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271805 US10065941, Compound R-120::US9732060, Compound R-120 P2X purinoceptor 3 Homo sapiens 8.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271805 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271805&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295556 378153631 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655646 CC(C)(Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cncc(F)c3)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O InChI=1S/C26H22ClF2N5O5/c1-26(2,22(35)36)14-34-24(37)32-23(33(25(34)38)13-15-3-5-16(27)6-4-15)31-18-7-8-21(20(29)10-18)39-19-9-17(28)11-30-12-19/h3-12H,13-14H2,1-2H3,(H,35,36)(H,31,32,37) XSOKLAWFOKUOIO-UHFFFAOYSA-N 271806 US10065941, Compound R-121::US9732060, Compound R-121 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271806 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271806&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295563 378153632 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655647 COC(=O)[C@H](C)[C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3cnccn3)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O 271807 US10065941, Compound R-122::US9732060, Compound R-122 P2X purinoceptor 3 Homo sapiens 13.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271807 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271807&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295564 378153633 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655648 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccnc(c3)C#N)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271808 US10065941, Compound R-123::US9732060, Compound R-123 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271808 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271808&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295562 378153634 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655649 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cc(Cl)ncn3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271809 US10065941, Compound R-124::US9732060, Compound R-124 P2X purinoceptor 3 Homo sapiens 9.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271809 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271809&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295558 378153635 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655650 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3cnccn3)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271810 US10065941, Compound R-125::US9732060, Compound R-125 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271810 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271810&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295570 378153636 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655651 CC(C)(Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cc(O)nc(F)c3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O InChI=1S/C26H23ClFN5O6/c1-26(2,22(35)36)14-33-24(37)31-23(32(25(33)38)13-15-3-5-16(27)6-4-15)29-17-7-9-18(10-8-17)39-19-11-20(28)30-21(34)12-19/h3-12H,13-14H2,1-2H3,(H,30,34)(H,35,36)(H,29,31,37) CMJTXAPIMGIDHG-UHFFFAOYSA-N 271811 US10065941, Compound R-126::US9732060, Compound R-126 P2X purinoceptor 3 Homo sapiens 10.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271811 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271811&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295566 378153637 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655652 CCc1[nH]c2ccc(cc2c1C)\N=c1/[nH]c(=O)n([C@@H](C)[C@@H](C)C(=O)OC)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C27H28ClN5O4/c1-6-22-16(3)21-13-20(11-12-23(21)30-22)29-25-31-26(35)33(17(4)15(2)24(34)37-5)27(36)32(25)14-18-7-9-19(28)10-8-18/h7-13,15,17H,6,14H2,1-5H3/b29-20-/t15-,17+/m1/s1 FDWOMSKDNMJJPE-RDGVBXFPSA-N 271812 US10065941, Compound R-127::US9732060, Compound R-127 P2X purinoceptor 3 Homo sapiens 90.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271812 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271812&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295575 378153638 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655653 CCc1[nH]c2ccc(cc2c1C)\N=c1/[nH]c(=O)n([C@@H](C)[C@@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C26H26ClN5O4/c1-5-21-15(3)20-12-19(10-11-22(20)29-21)28-24-30-25(35)32(16(4)14(2)23(33)34)26(36)31(24)13-17-6-8-18(27)9-7-17/h6-12,14,16H,5,13H2,1-4H3,(H,33,34)/b28-19-/t14-,16+/m1/s1 XDFRWSJUTDCGQB-GLXKCUSFSA-N 271813 US10065941, Compound R-128::US9732060, Compound R-128 P2X purinoceptor 3 Homo sapiens 11.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271813 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271813&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752293 378153639 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655654 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cnccn3)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C27H27ClN6O5/c1-17-13-20(9-10-21(17)39-22-14-29-11-12-30-22)31-24-32-25(36)34(16-27(2,3)23(35)38-4)26(37)33(24)15-18-5-7-19(28)8-6-18/h5-14H,15-16H2,1-4H3,(H,31,32,36) RKIMLVWCCFPVCI-UHFFFAOYSA-N 271814 US10065941, Compound R-129::US9732060, Compound R-129 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271814 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271814&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295565 378153640 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655655 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cnccn3)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271815 US10065941, Compound R-130::US9732060, Compound R-130 P2X purinoceptor 3 Homo sapiens 9.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271815 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271815&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295571 378153641 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655656 Cc1cc(ccc1Oc1cnccn1)\N=c1/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C26H25ClN6O5/c1-16-12-19(8-9-20(16)38-21-13-28-10-11-29-21)30-23-31-24(36)33(15-26(2,3)22(34)35)25(37)32(23)14-17-4-6-18(27)7-5-17/h4-13H,14-15H2,1-3H3,(H,34,35)(H,30,31,36) SWFJHVFHEQBLND-UHFFFAOYSA-N 271816 US10065941, Compound R-131::US9732060, Compound R-131 P2X purinoceptor 3 Homo sapiens 9.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271816 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271816&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295567 378153642 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655657 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ncc(C)s3)cc2)n(Cc2ccc(Cl)cc2)c1=O 271817 US10065941, Compound R-132::US9732060, Compound R-132 P2X purinoceptor 3 Homo sapiens 10.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271817 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271817&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295572 378153643 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655658 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ncc(C)s3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271818 US10065941, Compound R-133::US9732060, Compound R-133 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271818 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271818&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295576 378153644 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655659 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ncns3)cc2)n(Cc2ccc(Cl)cc2)c1=O 271819 US10065941, Compound R-134::US9732060, Compound R-134 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271819 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271819&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295573 378153645 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655660 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3nc(C)ns3)cc2)n(Cc2ccc(Cl)cc2)c1=O 271820 US10065941, Compound R-135::US9732060, Compound R-135 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271820 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271820&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295578 378153646 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655661 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ncns3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H23ClN6O5S/c1-24(2,19(32)35-3)13-31-21(33)29-20(30(23(31)34)12-15-4-6-16(25)7-5-15)28-17-8-10-18(11-9-17)36-22-26-14-27-37-22/h4-11,14H,12-13H2,1-3H3,(H,28,29,33) XODHWXOHXJMVJO-UHFFFAOYSA-N 271821 US10065941, Compound R-136::US9732060, Compound R-136 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271821 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271821&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752142 378153647 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655662 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3nc(C)ns3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H25ClN6O5S/c1-15-27-23(38-30-15)37-19-11-9-18(10-12-19)28-21-29-22(34)32(14-25(2,3)20(33)36-4)24(35)31(21)13-16-5-7-17(26)8-6-16/h5-12H,13-14H2,1-4H3,(H,28,29,34) CNCYBVBAYGXZCL-UHFFFAOYSA-N 271822 US10065941, Compound R-137::US9732060, Compound R-137 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271822 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271822&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752139 378153648 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655663 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(N3CCCCC3)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O 271823 US10065941, Compound R-138::US9732060, Compound R-138 P2X purinoceptor 3 Homo sapiens 78.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271823 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271823&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752144 378153649 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655664 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(N3CCCCC3)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C28H34ClN5O4/c1-19-16-22(12-13-23(19)32-14-6-5-7-15-32)30-25-31-26(36)34(18-28(2,3)24(35)38-4)27(37)33(25)17-20-8-10-21(29)11-9-20/h8-13,16H,5-7,14-15,17-18H2,1-4H3,(H,30,31,36) CKTYKROLHIXLDK-UHFFFAOYSA-N 271824 US10065941, Compound R-139::US9732060, Compound R-139 P2X purinoceptor 3 Homo sapiens 119 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271824 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271824&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752138 378153650 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655665 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(N3CCCCC3)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O 271825 US10065941, Compound R-140::US9732060, Compound R-140 P2X purinoceptor 3 Homo sapiens 37.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271825 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271825&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752143 378153651 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655666 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(N3CCCCC3)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C27H31ClFN5O4/c1-27(2,23(35)38-3)17-34-25(36)31-24(33(26(34)37)16-18-7-9-19(28)10-8-18)30-20-11-12-22(21(29)15-20)32-13-5-4-6-14-32/h7-12,15H,4-6,13-14,16-17H2,1-3H3,(H,30,31,36) AGMBICPMWBNFMR-UHFFFAOYSA-N 271826 US10065941, Compound R-141::US9732060, Compound R-141 P2X purinoceptor 3 Homo sapiens 47.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271826 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271826&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752299 378153652 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655667 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(N3CCCCC3)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271827 US10065941, Compound R-142::US9732060, Compound R-142 P2X purinoceptor 3 Homo sapiens 69.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271827 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271827&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295577 378153653 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655668 Cc1cc(ccc1N1CCCCC1)\N=c1/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C27H32ClN5O4/c1-18-15-21(11-12-22(18)31-13-5-4-6-14-31)29-24-30-25(36)33(17-27(2,3)23(34)35)26(37)32(24)16-19-7-9-20(28)10-8-19/h7-12,15H,4-6,13-14,16-17H2,1-3H3,(H,34,35)(H,29,30,36) JKKCFNJXHOZGNW-UHFFFAOYSA-N 271828 US10065941, Compound R-143::US9732060, Compound R-143 P2X purinoceptor 3 Homo sapiens 97.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271828 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271828&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295574 378153654 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655669 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3nc4ccccc4o3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271829 US10065941, Compound R-144::US9732060, Compound R-144 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271829 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271829&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121285495 378153655 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655670 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3nc(ns3)C(F)(F)F)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271830 US10065941, Compound R-145::US9732060, Compound R-145 P2X purinoceptor 3 Homo sapiens 11.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271830 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271830&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295580 378153656 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655671 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(N3CCCCC3)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271831 US10065941, Compound R-146::US9732060, Compound R-146 P2X purinoceptor 3 Homo sapiens 33.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271831 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271831&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295579 378153657 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655672 CC(C)(Cn1c(=O)[nH]\c(=N/c2ccc(N3CCCCC3)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O InChI=1S/C26H29ClFN5O4/c1-26(2,22(34)35)16-33-24(36)30-23(32(25(33)37)15-17-6-8-18(27)9-7-17)29-19-10-11-21(20(28)14-19)31-12-4-3-5-13-31/h6-11,14H,3-5,12-13,15-16H2,1-2H3,(H,34,35)(H,29,30,36) GFTDAWBEZBEPMF-UHFFFAOYSA-N 271832 US10065941, Compound R-147::US9732060, Compound R-147 P2X purinoceptor 3 Homo sapiens 51.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271832 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271832&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295581 378153658 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655673 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cccnn3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H25ClN6O5/c1-26(2,22(34)37-3)16-33-24(35)30-23(32(25(33)36)15-17-6-8-18(27)9-7-17)29-19-10-12-20(13-11-19)38-21-5-4-14-28-31-21/h4-14H,15-16H2,1-3H3,(H,29,30,35) ISPFGUTVHDTCJL-UHFFFAOYSA-N 271833 US10065941, Compound R-148::US9732060, Compound R-148 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271833 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271833&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295587 378153659 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655674 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ncc(C)s3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H26ClN5O5S/c1-16-13-28-24(38-16)37-20-11-9-19(10-12-20)29-22-30-23(34)32(15-26(2,3)21(33)36-4)25(35)31(22)14-17-5-7-18(27)8-6-17/h5-13H,14-15H2,1-4H3,(H,29,30,34) PMBCKYFCNMPDLZ-UHFFFAOYSA-N 271834 US10065941, Compound R-149::US9732060, Compound R-149 P2X purinoceptor 3 Homo sapiens 12.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271834 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271834&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295582 378153660 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655675 COC(=O)[C@H](C)[C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3ccnc(Cl)c3)cc2)n(Cc2ccc(Cl)cc2)c1=O 271835 US10065941, Compound R-150::US9732060, Compound R-150 P2X purinoceptor 3 Homo sapiens 18.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271835 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271835&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295583 378153661 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655676 CC(C)(Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cccnn3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O InChI=1S/C25H23ClN6O5/c1-25(2,21(33)34)15-32-23(35)29-22(31(24(32)36)14-16-5-7-17(26)8-6-16)28-18-9-11-19(12-10-18)37-20-4-3-13-27-30-20/h3-13H,14-15H2,1-2H3,(H,33,34)(H,28,29,35) QQBSQBSYKBIUHZ-UHFFFAOYSA-N 271836 US10065941, Compound R-151::US9732060, Compound R-151 P2X purinoceptor 3 Homo sapiens 11.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271836 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271836&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295584 378153662 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655677 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(CO)nc3)cc2)n(Cc2ccc(Cl)cc2)c1=O 271837 US10065941, Compound R-152::US9732060, Compound R-152 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271837 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271837&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295585 378153663 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655678 Cc1cnc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n2Cc2ccc(Cl)cc2)s1 InChI=1S/C25H24ClN5O5S/c1-15-12-27-23(37-15)36-19-10-8-18(9-11-19)28-21-29-22(34)31(14-25(2,3)20(32)33)24(35)30(21)13-16-4-6-17(26)7-5-16/h4-12H,13-14H2,1-3H3,(H,32,33)(H,28,29,34) RHUMXFQDEKHVKS-UHFFFAOYSA-N 271838 US10065941, Compound R-153::US9732060, Compound R-153 P2X purinoceptor 3 Homo sapiens 8.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271838 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271838&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295586 378153664 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655679 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3ccnc(Cl)c3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271839 US10065941, Compound R-154::US9732060, Compound R-154 P2X purinoceptor 3 Homo sapiens 8.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271839 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271839&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295588 378153665 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655680 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(CO)nc3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271840 US10065941, Compound R-155::US9732060, Compound R-155 P2X purinoceptor 3 Homo sapiens 10.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271840 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271840&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295589 378153666 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655681 COC(=O)[C@H](C)[C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3cc(F)nc(F)c3)cc2)n(Cc2ccc(Cl)cc2)c1=O 271841 US10065941, Compound R-156::US9732060, Compound R-156 P2X purinoceptor 3 Homo sapiens 35.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271841 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271841&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295591 378153667 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655682 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3cc(F)nc(F)c3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271842 US10065941, Compound R-157::US9732060, Compound R-157 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271842 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271842&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295590 378153668 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655683 COC(=O)[C@H](C)[C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3cnccn3)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O 271843 US10065941, Compound R-158::US9732060, Compound R-158 P2X purinoceptor 3 Homo sapiens 12.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271843 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271843&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295595 378153669 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655684 COC(=O)[C@H](C)[C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3cnc(Cl)cn3)cc2)n(Cc2ccc(Cl)cc2)c1=O 271844 US10065941, Compound R-159::US9732060, Compound R-159 P2X purinoceptor 3 Homo sapiens 18.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271844 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271844&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295592 378153670 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655685 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3nc(C)ns3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271845 US10065941, Compound R-160::US9732060, Compound R-160 P2X purinoceptor 3 Homo sapiens 8.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271845 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271845&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295593 378153671 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655686 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3cnccn3)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271846 US10065941, Compound R-161::US9732060, Compound R-161 P2X purinoceptor 3 Homo sapiens 10.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271846 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271846&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295594 378153672 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655687 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3cnc(Cl)cn3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271847 US10065941, Compound R-162::US9732060, Compound R-162 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271847 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271847&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295596 378153673 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655688 CC(C)(Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ncns3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O InChI=1S/C23H21ClN6O5S/c1-23(2,18(31)32)12-30-20(33)28-19(29(22(30)34)11-14-3-5-15(24)6-4-14)27-16-7-9-17(10-8-16)35-21-25-13-26-36-21/h3-10,13H,11-12H2,1-2H3,(H,31,32)(H,27,28,33) OULBKUOAELQZGM-UHFFFAOYSA-N 271848 US10065941, Compound R-163::US9732060, Compound R-163 P2X purinoceptor 3 Homo sapiens 14.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271848 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271848&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295597 378153674 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655689 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ncccn3)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271849 US10065941, Compound R-164::US9732060, Compound R-164 P2X purinoceptor 3 Homo sapiens 10.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271849 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271849&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295598 378153675 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655690 CC(C)(Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ncccn3)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O InChI=1S/C25H22ClFN6O5/c1-25(2,20(34)35)14-33-23(36)31-21(32(24(33)37)13-15-4-6-16(26)7-5-15)30-17-8-9-19(18(27)12-17)38-22-28-10-3-11-29-22/h3-12H,13-14H2,1-2H3,(H,34,35)(H,30,31,36) RFSGUIFDSOVYAO-UHFFFAOYSA-N 271850 US10065941, Compound R-165::US9732060, Compound R-165 P2X purinoceptor 3 Homo sapiens 14.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271850 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271850&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295603 378153676 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655691 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(Cl)nc3C#N)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H18Cl2N6O3/c1-2-31-23(33)30-22(32(24(31)34)14-15-3-5-16(25)6-4-15)28-17-7-9-18(10-8-17)35-20-11-12-21(26)29-19(20)13-27/h3-12H,2,14H2,1H3,(H,28,30,33) ARHZRZCBKBPGBZ-UHFFFAOYSA-N 271851 US10065941, Compound R-166::US9732060, Compound R-166 P2X purinoceptor 3 Homo sapiens 48.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271851 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271851&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295600 378153677 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655692 COC(=O)[C@H](C)[C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3cnccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O 271852 US10065941, Compound R-167::US9732060, Compound R-167 P2X purinoceptor 3 Homo sapiens 11.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271852 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271852&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295599 378153678 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655693 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3cnccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271853 US10065941, Compound R-168::US9732060, Compound R-168 P2X purinoceptor 3 Homo sapiens 17.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271853 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271853&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295605 378153679 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655694 CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(Cl)nc3C(O)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H19Cl2N5O5/c1-2-30-23(34)29-22(31(24(30)35)13-14-3-5-15(25)6-4-14)27-16-7-9-17(10-8-16)36-18-11-12-19(26)28-20(18)21(32)33/h3-12H,2,13H2,1H3,(H,32,33)(H,27,29,34) XVYZHOYKZRXTDO-UHFFFAOYSA-N 271854 US10065941, Compound R-169::US9732060, Compound R-169 P2X purinoceptor 3 Homo sapiens 304 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271854 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271854&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295602 378153680 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655695 Fc1ccc(Oc2ccc(cc2)\N=c2/[nH]c(=O)[nH]c(=O)n2Cc2ccc(Cl)cc2)nc1 InChI=1S/C21H15ClFN5O3/c22-14-3-1-13(2-4-14)12-28-19(26-20(29)27-21(28)30)25-16-6-8-17(9-7-16)31-18-10-5-15(23)11-24-18/h1-11H,12H2,(H2,25,26,27,29,30) OOPDVFQPCDWAPL-UHFFFAOYSA-N 271855 US10065941, Compound R-170::US9732060, Compound R-170 P2X purinoceptor 3 Homo sapiens 193 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271855 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271855&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295601 378153681 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655696 CCOC(=O)C[C@H](O)Cn1c(=O)[nH]\c(=N/c2ccc(OC(C)C)c(Cl)c2)n(Cc2ccc(Cl)cc2)c1=O 271856 US10065941, Compound R-171::US9732060, Compound R-171 P2X purinoceptor 3 Homo sapiens 33.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271856 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271856&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295607 378153682 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655697 CCOC(=O)C[C@H](O)Cn1c(=O)[nH]\c(=N/c2ccc3oc(CC)c(C)c3c2)n(Cc2ccc(Cl)cc2)c1=O 271857 US10065941, Compound R-172::US9732060, Compound R-172 P2X purinoceptor 3 Homo sapiens 33.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271857 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271857&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295604 378153683 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655698 CCc1oc2ccc(cc2c1C)\N=c1/[nH]c(=O)[nH]c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C21H19ClN4O3/c1-3-17-12(2)16-10-15(8-9-18(16)29-17)23-19-24-20(27)25-21(28)26(19)11-13-4-6-14(22)7-5-13/h4-10H,3,11H2,1-2H3,(H2,23,24,25,27,28) URHKDBSSKFINEU-UHFFFAOYSA-N 271858 US10065941, Compound R-173::US9732060, Compound R-173 P2X purinoceptor 3 Homo sapiens 376 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271858 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271858&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295606 378153684 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655699 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(C)nn3)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O 271859 US10065941, Compound R-174::US9732060, Compound R-174 P2X purinoceptor 3 Homo sapiens 10.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271859 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271859&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295608 378153685 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655700 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(C)nn3)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C27H26ClFN6O5/c1-16-5-12-22(33-32-16)40-21-11-10-19(13-20(21)29)30-24-31-25(37)35(15-27(2,3)23(36)39-4)26(38)34(24)14-17-6-8-18(28)9-7-17/h5-13H,14-15H2,1-4H3,(H,30,31,37) JHKNZMKKBIVIPS-UHFFFAOYSA-N 271860 US10065941, Compound R-175::US9732060, Compound R-175 P2X purinoceptor 3 Homo sapiens 19.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271860 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271860&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295610 378153686 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655701 CC(C)(Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cnc(cn3)C(F)(F)F)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O InChI=1S/C26H22ClF3N6O5/c1-25(2,21(37)38)14-36-23(39)34-22(35(24(36)40)13-15-3-5-16(27)6-4-15)33-17-7-9-18(10-8-17)41-20-12-31-19(11-32-20)26(28,29)30/h3-12H,13-14H2,1-2H3,(H,37,38)(H,33,34,39) YMWOXTBSFQHULD-UHFFFAOYSA-N 271861 US10065941, Compound R-176::US9732060, Compound R-176 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271861 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271861&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295609 378153687 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655702 COc1cc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n([C@@H](C)[C@@H](C)C(O)=O)c(=O)n2Cc2ccc(Cl)cc2)cc(F)n1 271862 US10065941, Compound R-177::US9732060, Compound R-177 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271862 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271862&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295611 378153688 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655703 CCc1oc2ccc(cc2c1C)\N=c1/[nH]c(=O)n(C[C@@H](O)CC(O)=O)c(=O)n1Cc1ccc(Cl)cc1 271863 US10065941, Compound R-178::US9732060, Compound R-178 P2X purinoceptor 3 Homo sapiens 45.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271863 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271863&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295612 378153689 C03834 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655704 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(C[C@@H](O)CC(O)=O)c(=O)n1Cc1ccc(Cl)cc1 271864 US10065941, Compound R-179::US9732060, Compound R-179 P2X purinoceptor 3 Homo sapiens 56.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271864 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271864&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752380 378153690 C03834 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655705 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(C)nn3)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271865 US10065941, Compound R-180::US9732060, Compound R-180 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271865 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271865&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295613 378153691 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655706 Cc1ccc(Oc2ccc(cc2F)\N=c2/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n2Cc2ccc(Cl)cc2)nn1 InChI=1S/C26H24ClFN6O5/c1-15-4-11-21(32-31-15)39-20-10-9-18(12-19(20)28)29-23-30-24(37)34(14-26(2,3)22(35)36)25(38)33(23)13-16-5-7-17(27)8-6-16/h4-12H,13-14H2,1-3H3,(H,35,36)(H,29,30,37) YGAKZTVQVXSYJE-UHFFFAOYSA-N 271866 US10065941, Compound R-181::US9732060, Compound R-181 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271866 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271866&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295614 378153692 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655707 COC(=O)[C@H](C)[C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3ncc(C)s3)cc2)n(Cc2ccc(Cl)cc2)c1=O 271867 US10065941, Compound R-182::US9732060, Compound R-182 P2X purinoceptor 3 Homo sapiens 26.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271867 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271867&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295615 378153693 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655708 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3ncc(C)s3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271868 US10065941, Compound R-183::US9732060, Compound R-183 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271868 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271868&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295616 378153694 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655709 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cncc(C)c3)cc2)n(Cc2ccc(Cl)cc2)c1=O 271869 US10065941, Compound R-184::US9732060, Compound R-184 P2X purinoceptor 3 Homo sapiens 10.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271869 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271869&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295617 378153695 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655710 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cncc(C)c3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271870 US10065941, Compound R-185::US9732060, Compound R-185 P2X purinoceptor 3 Homo sapiens 12.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271870 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271870&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295618 378153696 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655711 COC(=O)[C@H](C)[C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3cncc(F)c3)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O 271871 US10065941, Compound R-186::US9732060, Compound R-186 P2X purinoceptor 3 Homo sapiens 26.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271871 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271871&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295619 378153697 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655712 COC(=O)[C@H](C)[C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3cncc(F)c3)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O 271872 US10065941, Compound R-187::US9732060, Compound R-187 P2X purinoceptor 3 Homo sapiens 21.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271872 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271872&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295620 378153698 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655713 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3cncc(F)c3)c(C)c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271873 US10065941, Compound R-188::US9732060, Compound R-188 P2X purinoceptor 3 Homo sapiens 9.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271873 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271873&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295622 378153699 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655714 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3cncc(F)c3)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271874 US10065941, Compound R-189::US9732060, Compound R-189 P2X purinoceptor 3 Homo sapiens 8.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271874 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271874&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295623 378153700 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655715 COc1ccc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n2Cc2ccc(Cl)cc2)nn1 InChI=1S/C26H25ClN6O6/c1-26(2,22(34)35)15-33-24(36)29-23(32(25(33)37)14-16-4-6-17(27)7-5-16)28-18-8-10-19(11-9-18)39-21-13-12-20(38-3)30-31-21/h4-13H,14-15H2,1-3H3,(H,34,35)(H,28,29,36) LMXPTZDDFBNBKY-UHFFFAOYSA-N 271875 US10065941, Compound R-190::US9732060, Compound R-190 P2X purinoceptor 3 Homo sapiens 9.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271875 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271875&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295621 378153701 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655716 COc1ccc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n([C@@H](C)[C@@H](C)C(O)=O)c(=O)n2Cc2ccc(Cl)cc2)nn1 271876 US10065941, Compound R-191::US9732060, Compound R-191 P2X purinoceptor 3 Homo sapiens 12.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271876 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271876&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295624 378153702 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655717 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3nc4ccccc4s3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271877 US10065941, Compound R-192::US9732060, Compound R-192 P2X purinoceptor 3 Homo sapiens 4.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271877 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271877&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295626 378153703 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655718 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cncc(C)c3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C28H28ClN5O5/c1-18-13-23(15-30-14-18)39-22-11-9-21(10-12-22)31-25-32-26(36)34(17-28(2,3)24(35)38-4)27(37)33(25)16-19-5-7-20(29)8-6-19/h5-15H,16-17H2,1-4H3,(H,31,32,36) WKSOUTDTMVJOLB-UHFFFAOYSA-N 271878 US10065941, Compound R-193::US9732060, Compound R-193 P2X purinoceptor 3 Homo sapiens 11.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271878 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271878&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295625 378153704 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655719 Cc1cncc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n2Cc2ccc(Cl)cc2)c1 InChI=1S/C27H26ClN5O5/c1-17-12-22(14-29-13-17)38-21-10-8-20(9-11-21)30-24-31-25(36)33(16-27(2,3)23(34)35)26(37)32(24)15-18-4-6-19(28)7-5-18/h4-14H,15-16H2,1-3H3,(H,34,35)(H,30,31,36) INZKTCGPYXZVET-UHFFFAOYSA-N 271879 US10065941, Compound R-194::US9732060, Compound R-194 P2X purinoceptor 3 Homo sapiens 13.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271879 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271879&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295627 378153705 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655720 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ncns3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271880 US10065941, Compound R-195::US9732060, Compound R-195 P2X purinoceptor 3 Homo sapiens 9.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271880&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295628 378153706 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655721 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(F)nn3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271881 US10065941, Compound R-196::US9732060, Compound R-196 P2X purinoceptor 3 Homo sapiens 11.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271881 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271881&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295629 378153707 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655722 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(Cl)nn3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271882 US10065941, Compound R-197::US9732060, Compound R-197 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271882 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271882&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295630 378153708 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655723 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cc(F)ncn3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271883 US10065941, Compound R-198::US9732060, Compound R-198 P2X purinoceptor 3 Homo sapiens 9.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271883 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271883&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295631 378153709 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655724 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cncc(OC)c3)cc2)n(Cc2ccc(Cl)cc2)c1=O 271884 US10065941, Compound R-199::US9732060, Compound R-199 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271884 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271884&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295632 378153710 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655725 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cncc(OC)c3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C28H28ClN5O6/c1-28(2,24(35)39-4)17-34-26(36)32-25(33(27(34)37)16-18-5-7-19(29)8-6-18)31-20-9-11-21(12-10-20)40-23-13-22(38-3)14-30-15-23/h5-15H,16-17H2,1-4H3,(H,31,32,36) WYJTZZBVFCCLCK-UHFFFAOYSA-N 271885 US10065941, Compound R-200::US9732060, Compound R-200 P2X purinoceptor 3 Homo sapiens 8.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271885 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271885&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295633 378153711 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655726 COc1cncc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n2Cc2ccc(Cl)cc2)c1 271886 US10065941, Compound R-201::US9732060, Compound R-201 P2X purinoceptor 3 Homo sapiens 8.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271886 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271886&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295634 378153712 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655727 COc1cncc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n2Cc2ccc(Cl)cc2)c1 InChI=1S/C27H26ClN5O6/c1-27(2,23(34)35)16-33-25(36)31-24(32(26(33)37)15-17-4-6-18(28)7-5-17)30-19-8-10-20(11-9-19)39-22-12-21(38-3)13-29-14-22/h4-14H,15-16H2,1-3H3,(H,34,35)(H,30,31,36) OZLXGEWLOAZVPE-UHFFFAOYSA-N 271887 US10065941, Compound R-202::US9732060, Compound R-202 P2X purinoceptor 3 Homo sapiens 12.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271887 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271887&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295635 378153713 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655728 COC(=O)[C@H](C)[C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3cnc(cn3)C(N)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O 271888 US10065941, Compound R-203::US9732060, Compound R-203 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271888 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271888&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295636 378153714 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655729 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3nc4ncccc4o3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271889 US10065941, Compound R-204::US9732060, Compound R-204 P2X purinoceptor 3 Homo sapiens 8.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271889 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271889&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295637 378153715 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655730 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cccnc3)cc2)n(Cc2ccc(Cl)cc2)c1=O 271890 US10065941, Compound R-205::US9732060, Compound R-205 P2X purinoceptor 3 Homo sapiens 8.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271890 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271890&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295638 378153716 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655731 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccncc3)cc2)n(Cc2ccc(Cl)cc2)c1=O 271891 US10065941, Compound R-206::US9732060, Compound R-206 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271891 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271891&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295639 378153717 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655732 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cccnc3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271892 US10065941, Compound R-207::US9732060, Compound R-207 P2X purinoceptor 3 Homo sapiens 9.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271892 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271892&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295640 378153718 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655733 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccncc3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271893 US10065941, Compound R-208::US9732060, Compound R-208 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271893 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271893&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295641 378153719 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655734 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(C)nc3)cc2)n(Cc2ccc(cc2)C(O)(O)O)c1=O 334673 US9732060, Compound R-209 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=334673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=334673&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295642 384986833 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655735 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(C)nc3)cc2)n(Cc2ccc(cc2)C(O)(O)O)c1=O)C(O)=O 334674 US9732060, Compound R-210 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=334674 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=334674&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295645 384986834 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655736 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3nccnc3Cl)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271896 US10065941, Compound R-211::US9732060, Compound R-211 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271896 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271896&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295643 378153722 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655737 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3ccnc(c3)C#N)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271897 US10065941, Compound R-212::US9732060, Compound R-212 P2X purinoceptor 3 Homo sapiens 8.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271897 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271897&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295644 378153723 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655738 COC(=O)[C@H](C)[C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3ncc(C)s3)cc2)n(Cc2ccc(C)cc2)c1=O 271898 US10065941, Compound R-213::US9732060, Compound R-213 P2X purinoceptor 3 Homo sapiens 12.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271898 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271898&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752216 378153724 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655739 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ncc(C)s3)cc2)n(Cc2ccc(C)cc2)c1=O 271899 US10065941, Compound R-214::US9732060, Compound R-214 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271899 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271899&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752208 378153725 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655740 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ncc(C)s3)cc2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C27H29N5O5S/c1-17-6-8-19(9-7-17)15-31-23(30-24(34)32(26(31)35)16-27(3,4)22(33)36-5)29-20-10-12-21(13-11-20)37-25-28-14-18(2)38-25/h6-14H,15-16H2,1-5H3,(H,29,30,34) XDFBZWHMTGAIKP-UHFFFAOYSA-N 271900 US10065941, Compound R-215::US9732060, Compound R-215 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271900 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271900&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752204 378153726 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655741 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(OC(F)F)cn3)cc2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 271637 US10065941, Compound I-138::US10065941, Compound R-216::US9732060, Compound R-216 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271637 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271637&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752285 378153463 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655742 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3ncc(C)s3)cc2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 271902 US10065941, Compound R-217::US9732060, Compound R-217 P2X purinoceptor 3 Homo sapiens 8.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271902 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271902&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295646 378153727 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655743 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ncc(C)s3)cc2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 271903 US10065941, Compound R-218::US9732060, Compound R-218 P2X purinoceptor 3 Homo sapiens 8.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271903 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271903&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752370 378153728 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655744 Cc1cnc(Oc2ccc(cc2)\N=c2/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n2Cc2ccc(C)cc2)s1 InChI=1S/C26H27N5O5S/c1-16-5-7-18(8-6-16)14-30-22(29-23(34)31(25(30)35)15-26(3,4)21(32)33)28-19-9-11-20(12-10-19)36-24-27-13-17(2)37-24/h5-13H,14-15H2,1-4H3,(H,32,33)(H,28,29,34) UJCKNJWAXXRDNS-UHFFFAOYSA-N 271904 US10065941, Compound R-219::US9732060, Compound R-219 P2X purinoceptor 3 Homo sapiens 11.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271904 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271904&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752390 378153729 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655745 CCc1oc2ccc(cc2c1C)\N=c1/[nH]c(=O)n(C[C@H](C)C(=O)OC)c(=O)n1Cc1ccc(C)cc1 271905 US10065941, Compound R-220::US9732060, Compound R-220 P2X purinoceptor 3 Homo sapiens 22.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271905 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271905&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752371 378153730 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655746 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccnc(F)c3)cc2)n(Cc2ccc(C)cc2)c1=O 271906 US10065941, Compound R-221::US9732060, Compound R-221 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271906 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271906&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752393 378153731 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655747 CCc1oc2ccc(cc2c1C)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(C)cc1 271907 US10065941, Compound R-222::US9732060, Compound R-222 P2X purinoceptor 3 Homo sapiens 9.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271907 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271907&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752394 378153732 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655748 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccnc(F)c3)cc2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 271908 US10065941, Compound R-223::US9732060, Compound R-223 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271908 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271908&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752384 378153733 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655749 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3cnc(cn3)C#N)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271909 US10065941, Compound R-224::US9732060, Compound R-224 P2X purinoceptor 3 Homo sapiens 12.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271909 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271909&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295648 378153734 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655750 COC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H22ClN5O5/c1-35-22(32)13-15-30-24(33)29-23(31(25(30)34)16-17-5-7-18(26)8-6-17)28-19-9-11-20(12-10-19)36-21-4-2-3-14-27-21/h2-12,14H,13,15-16H2,1H3,(H,28,29,33) AGHQUXOVNXUKMS-UHFFFAOYSA-N 271910 US10065941, Compound R-225::US9732060, Compound R-225 P2X purinoceptor 3 Homo sapiens 4.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271910 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271910&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295647 378153735 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655751 COC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(Cc2ccc(C)cc2)c1=O InChI=1S/C26H25N5O5/c1-18-6-8-19(9-7-18)17-31-24(29-25(33)30(26(31)34)16-14-23(32)35-2)28-20-10-12-21(13-11-20)36-22-5-3-4-15-27-22/h3-13,15H,14,16-17H2,1-2H3,(H,28,29,33) NRPWMDSRMHLJBB-UHFFFAOYSA-N 271911 US10065941, Compound R-226::US9732060, Compound R-226 P2X purinoceptor 3 Homo sapiens 3.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271911 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271911&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752341 378153736 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655752 COC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(cc2)-n2ccccc2=O)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H22ClN5O5/c1-36-22(33)13-15-30-24(34)28-23(31(25(30)35)16-17-5-7-18(26)8-6-17)27-19-9-11-20(12-10-19)29-14-3-2-4-21(29)32/h2-12,14H,13,15-16H2,1H3,(H,27,28,34) OXXYAGJVAQBRQC-UHFFFAOYSA-N 271912 US10065941, Compound R-227::US9732060, Compound R-227 P2X purinoceptor 3 Homo sapiens 35.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271912 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271912&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752336 378153737 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655753 NC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H21ClN6O4/c25-17-6-4-16(5-7-17)15-31-22(29-23(33)30(24(31)34)14-12-20(26)32)28-18-8-10-19(11-9-18)35-21-3-1-2-13-27-21/h1-11,13H,12,14-15H2,(H2,26,32)(H,28,29,33) UTHIDEBWLRUJBH-UHFFFAOYSA-N 271913 US10065941, Compound R-229::US9732060, Compound R-229 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271913 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271913&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295650 378153738 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655754 CNC(=O)CCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H23ClN6O4/c1-27-21(33)13-15-31-24(34)30-23(32(25(31)35)16-17-5-7-18(26)8-6-17)29-19-9-11-20(12-10-19)36-22-4-2-3-14-28-22/h2-12,14H,13,15-16H2,1H3,(H,27,33)(H,29,30,34) WNJRTUVEKILBQG-UHFFFAOYSA-N 271914 US10065941, Compound R-230::US9732060, Compound R-230 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271914 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271914&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295651 378153739 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655755 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc4nccn4n3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271915 US10065941, Compound R-231::US9732060, Compound R-231 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271915 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271915&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295652 378153740 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655756 COc1nc(=O)n(Cc2ccc(Cl)cc2)\c(=N\c2ccc(Oc3cccc(n3)C#N)cc2)[nH]1 InChI=1S/C23H17ClN6O3/c1-32-22-28-21(30(23(31)29-22)14-15-5-7-16(24)8-6-15)27-17-9-11-19(12-10-17)33-20-4-2-3-18(13-25)26-20/h2-12H,14H2,1H3,(H,27,28,29,31) DNWLHVYOCFEBTF-UHFFFAOYSA-N 271916 US10065941, Compound R-232::US9732060, Compound R-232 P2X purinoceptor 3 Homo sapiens 61.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271916 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271916&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 136213974 378153741 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655757 CC(C)(C)n1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(n3)C(N)=O)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H25ClN6O4/c1-26(2,3)33-24(35)31-23(32(25(33)36)15-16-7-9-17(27)10-8-16)29-18-11-13-19(14-12-18)37-21-6-4-5-20(30-21)22(28)34/h4-14H,15H2,1-3H3,(H2,28,34)(H,29,31,35) PYPJFXASTVCJMD-UHFFFAOYSA-N 271917 US10065941, Compound R-233::US9732060, Compound R-233 P2X purinoceptor 3 Homo sapiens 318 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271917 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271917&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295654 378153742 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655758 CC1(C)OC[C@H](Cn2c(=O)[nH]\c(=N/c3ccc(Oc4ccccn4)cc3)n(Cc3ccc(Cl)cc3)c2=O)O1 271918 US10065941, Compound R-234::US9732060, Compound R-234 P2X purinoceptor 3 Homo sapiens 3.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271918 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271918&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295655 378153743 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655759 OC[C@@H](O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O 271919 US10065941, Compound R-235::US9732060, Compound R-235 P2X purinoceptor 3 Homo sapiens 10.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271919 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271919&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295656 378153744 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655760 CC1(C)OCC(C)(Cn2c(=O)[nH]\c(=N/c3ccc(Oc4ccccn4)cc3)n(Cc3ccc(Cl)cc3)c2=O)CO1 InChI=1S/C29H30ClN5O5/c1-28(2)38-18-29(3,19-39-28)17-35-26(36)33-25(34(27(35)37)16-20-7-9-21(30)10-8-20)32-22-11-13-23(14-12-22)40-24-6-4-5-15-31-24/h4-15H,16-19H2,1-3H3,(H,32,33,36) GOSGGPPJIMUUDR-UHFFFAOYSA-N 271920 US10065941, Compound R-236::US9732060, Compound R-236 P2X purinoceptor 3 Homo sapiens 4.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271920 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271920&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295657 378153745 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655761 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3nccnc3C)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271921 US10065941, Compound R-237::US9732060, Compound R-237 P2X purinoceptor 3 Homo sapiens 9.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271921 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271921&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295658 378153746 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655762 COC(=O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H20ClN5O5/c1-34-21(31)15-30-23(32)28-22(29(24(30)33)14-16-5-7-17(25)8-6-16)27-18-9-11-19(12-10-18)35-20-4-2-3-13-26-20/h2-13H,14-15H2,1H3,(H,27,28,32) NMKXGMIPEYCEOL-UHFFFAOYSA-N 271922 US10065941, Compound R-238::US9732060, Compound R-238 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271922 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271922&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752156 378153747 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655763 OC(=O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H18ClN5O5/c24-16-6-4-15(5-7-16)13-28-21(27-22(32)29(23(28)33)14-20(30)31)26-17-8-10-18(11-9-17)34-19-3-1-2-12-25-19/h1-12H,13-14H2,(H,30,31)(H,26,27,32) TXNDKVHGFNMHSL-UHFFFAOYSA-N 271923 US10065941, Compound R-239::US9732060, Compound R-239 P2X purinoceptor 3 Homo sapiens 399 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271923 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271923&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752177 378153748 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655764 NC(=O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H19ClN6O4/c24-16-6-4-15(5-7-16)13-29-21(28-22(32)30(23(29)33)14-19(25)31)27-17-8-10-18(11-9-17)34-20-3-1-2-12-26-20/h1-12H,13-14H2,(H2,25,31)(H,27,28,32) JXBOZMIMUSXUCX-UHFFFAOYSA-N 271924 US10065941, Compound R-240::US9732060, Compound R-240 P2X purinoceptor 3 Homo sapiens 11.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271924 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271924&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121280814 378153749 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655765 CNC(=O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H21ClN6O4/c1-26-20(32)15-31-23(33)29-22(30(24(31)34)14-16-5-7-17(25)8-6-16)28-18-9-11-19(12-10-18)35-21-4-2-3-13-27-21/h2-13H,14-15H2,1H3,(H,26,32)(H,28,29,33) JESKUQDYORHETP-UHFFFAOYSA-N 271925 US10065941, Compound R-241::US9732060, Compound R-241 P2X purinoceptor 3 Homo sapiens 9.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271925 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271925&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121296421 378153750 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655766 OCCNC(=O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H23ClN6O5/c26-18-6-4-17(5-7-18)15-31-23(30-24(35)32(25(31)36)16-21(34)27-13-14-33)29-19-8-10-20(11-9-19)37-22-3-1-2-12-28-22/h1-12,33H,13-16H2,(H,27,34)(H,29,30,35) UCNSAORDZKTNGO-UHFFFAOYSA-N 271926 US10065941, Compound R-242::US9732060, Compound R-242 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271926 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271926&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121296423 378153751 C04080 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655767 FC(F)(F)CNC(=O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H20ClF3N6O4/c26-17-6-4-16(5-7-17)13-34-22(32-18-8-10-19(11-9-18)39-21-3-1-2-12-30-21)33-23(37)35(24(34)38)14-20(36)31-15-25(27,28)29/h1-12H,13-15H2,(H,31,36)(H,32,33,37) RXYNFALWOGFABI-UHFFFAOYSA-N 271927 US10065941, Compound R-243::US9732060, Compound R-243 P2X purinoceptor 3 Homo sapiens 4.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271927 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271927&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121296415 378153752 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655768 CC(CO)(CO)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C26H26ClN5O5/c1-26(16-33,17-34)15-32-24(35)30-23(31(25(32)36)14-18-5-7-19(27)8-6-18)29-20-9-11-21(12-10-20)37-22-4-2-3-13-28-22/h2-13,33-34H,14-17H2,1H3,(H,29,30,35) HFXSNXQMXQZJOF-UHFFFAOYSA-N 271928 US10065941, Compound R-244::US9732060, Compound R-244 P2X purinoceptor 3 Homo sapiens 4.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271928 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271928&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295659 378153753 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655769 CC1(C)OCC(Cn2c(=O)[nH]\c(=N/c3ccc(Oc4ccccn4)cc3)n(Cc3ccc(Cl)cc3)c2=O)CO1 InChI=1S/C28H28ClN5O5/c1-28(2)37-17-20(18-38-28)16-34-26(35)32-25(33(27(34)36)15-19-6-8-21(29)9-7-19)31-22-10-12-23(13-11-22)39-24-5-3-4-14-30-24/h3-14,20H,15-18H2,1-2H3,(H,31,32,35) RTXQHZGMWZFXHO-UHFFFAOYSA-N 271929 US10065941, Compound R-245::US9732060, Compound R-245 P2X purinoceptor 3 Homo sapiens 4.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271929 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271929&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295660 378153754 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655770 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cnc(nc3)C#N)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271930 US10065941, Compound R-246::US9732060, Compound R-246 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271930 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271930&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295661 378153755 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655771 CC1(C)OC[C@@H](Cn2c(=O)[nH]\c(=N/c3ccc(Oc4ccccn4)cc3)n(Cc3ccc(Cl)cc3)c2=O)O1 271931 US10065941, Compound R-247::US9732060, Compound R-247 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271931 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271931&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295662 378153756 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655772 Clc1ccc(Cn2c(=O)n(CCCOC3CCCCO3)c(=O)[nH]\c2=N/c2ccc(Oc3ccccn3)cc2)cc1 271932 US10065941, Compound R-248::US9732060, Compound R-248 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271932 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271932&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752157 378153757 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655773 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3cnc(nc3)C#N)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271933 US10065941, Compound R-249::US9732060, Compound R-249 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271933 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271933&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295663 378153758 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655774 OC[C@H](O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O 271934 US10065941, Compound R-250::US9732060, Compound R-250 P2X purinoceptor 3 Homo sapiens 9.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271934 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271934&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295664 378153759 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655775 OCCCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H22ClN5O4/c25-18-7-5-17(6-8-18)16-30-22(28-23(32)29(24(30)33)14-3-15-31)27-19-9-11-20(12-10-19)34-21-4-1-2-13-26-21/h1-2,4-13,31H,3,14-16H2,(H,27,28,32) KPGHPKPTWFHFPE-UHFFFAOYSA-N 271935 US10065941, Compound R-251::US9732060, Compound R-251 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271935 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271935&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752158 378153760 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655776 OCC(=C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H22ClN5O4/c1-17(16-32)14-31-24(33)29-23(30(25(31)34)15-18-5-7-19(26)8-6-18)28-20-9-11-21(12-10-20)35-22-4-2-3-13-27-22/h2-13,32H,1,14-16H2,(H,28,29,33) NAWNIYPIOZDJMJ-UHFFFAOYSA-N 271936 US10065941, Compound R-254::US9732060, Compound R-254 P2X purinoceptor 3 Homo sapiens 3.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271936 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271936&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752164 378153761 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655777 OCC(O)(CO)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H24ClN5O6/c26-18-6-4-17(5-7-18)13-30-22(29-23(34)31(24(30)35)14-25(36,15-32)16-33)28-19-8-10-20(11-9-19)37-21-3-1-2-12-27-21/h1-12,32-33,36H,13-16H2,(H,28,29,34) GACPIASDRFHZSF-UHFFFAOYSA-N 271937 US10065941, Compound R-255::US9732060, Compound R-255 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271937 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271937&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121280858 378153762 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655778 NC(=O)NC(=O)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C24H20ClN7O5/c25-16-6-4-15(5-7-16)13-31-22(30-23(35)32(24(31)36)14-19(33)29-21(26)34)28-17-8-10-18(11-9-17)37-20-3-1-2-12-27-20/h1-12H,13-14H2,(H,28,30,35)(H3,26,29,33,34) HRZSXWMCUMJBGW-UHFFFAOYSA-N 271938 US10065941, Compound R-256::US9732060, Compound R-256 P2X purinoceptor 3 Homo sapiens 2.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271938 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271938&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121296425 378153763 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655779 OCCn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H20ClN5O4/c24-17-6-4-16(5-7-17)15-29-21(27-22(31)28(13-14-30)23(29)32)26-18-8-10-19(11-9-18)33-20-3-1-2-12-25-20/h1-12,30H,13-15H2,(H,26,27,31) RQIVBOOYYUQQPU-UHFFFAOYSA-N 271939 US10065941, Compound R-257::US9732060, Compound R-257 P2X purinoceptor 3 Homo sapiens 10.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271939 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271939&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752310 378153764 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655780 CO[C@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271940 US10065941, Compound I-200::US9732060, Compound I-200 P2X purinoceptor 3 Homo sapiens 42.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271940 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271940&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752364 378153765 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655781 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(Cc2ccc(cc2)C(F)F)c1=O)C(O)=O 271942 US10065941, Compound I-201::US9732060, Compound I-201 P2X purinoceptor 3 Homo sapiens 13.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271942 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271942&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752365 378153767 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655782 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(CC2CCC3(CC3)CC2)c1=O)C(O)=O 271944 US10065941, Compound I-202::US9732060, Compound I-202 P2X purinoceptor 3 Homo sapiens 8.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271944 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271944&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752379 378153769 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655783 CO[C@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(=O)OC 271946 US10065941, Compound I-203::US9732060, Compound I-203 P2X purinoceptor 3 Homo sapiens 3.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271946 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271946&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752356 378153771 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655784 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)c(F)c2)n(Cc2ccc(C)cc2)c1=O 271948 US10065941, Compound I-204::US10065941, Compound I-253::US9732060, Compound I-204 P2X purinoceptor 3 Homo sapiens 4.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271948 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271948&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752354 378153773 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655785 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O 271950 US10065941, Compound I-205::US9732060, Compound I-205 P2X purinoceptor 3 Homo sapiens 12.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271950 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271950&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752115 378153775 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655786 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(Cc2ccc(CF)cc2)c1=O 271952 US10065941, Compound I-206::US9732060, Compound I-206 P2X purinoceptor 3 Homo sapiens 10.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271952 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271952&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295436 378153777 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655787 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ncccc3F)cc2)n(Cc2ccc(CF)cc2)c1=O 271954 US10065941, Compound I-207::US9732060, Compound I-207 P2X purinoceptor 3 Homo sapiens 12.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271954 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271954&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752116 378153779 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655788 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(F)cn3)cc2)n(Cc2ccc(CF)cc2)c1=O 271956 US10065941, Compound I-208::US9732060, Compound I-208 P2X purinoceptor 3 Homo sapiens 12.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271956 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271956&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752117 378153781 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655789 COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(F)n3)cc2)n(Cc2ccc(CF)cc2)c1=O 271958 US10065941, Compound I-209::US9732060, Compound I-209 P2X purinoceptor 3 Homo sapiens 8.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271958 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271958&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752133 378153783 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655790 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)c(F)c2)n(Cc2ccc(C)cc2)c1=O)C(O)=O 271960 US10065941, Compound I-210::US9732060, Compound I-210 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271960 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271960&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295439 378153785 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655791 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271962 US10065941, Compound I-211::US9732060, Compound I-211 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271962 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271962&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752241 378153787 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655340 COC(=O)[C@H](C)[C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(F)cn3)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O 271500 US10065941, Compound I-001::US9732060, Compound I-001 P2X purinoceptor 3 Homo sapiens 44.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271500 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271500&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752166 378153328 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655341 C[C@H]([C@H](C)n1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(F)cn3)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271501 US10065941, Compound I-002::US9732060, Compound I-002 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271501 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271501&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752228 378153329 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655342 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(F)cn3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C27H25ClFN5O5/c1-27(2,23(35)38-3)16-34-25(36)32-24(33(26(34)37)15-17-4-6-18(28)7-5-17)31-20-9-11-21(12-10-20)39-22-13-8-19(29)14-30-22/h4-14H,15-16H2,1-3H3,(H,31,32,36) IKHMJSCTIDRHBS-UHFFFAOYSA-N 271502 US10065941, Compound I-003::US9732060, Compound I-003 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271502 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271502&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752218 378153330 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655343 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(Cl)cn3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C27H25Cl2N5O5/c1-27(2,23(35)38-3)16-34-25(36)32-24(33(26(34)37)15-17-4-6-18(28)7-5-17)31-20-9-11-21(12-10-20)39-22-13-8-19(29)14-30-22/h4-14H,15-16H2,1-3H3,(H,31,32,36) ILATUGAAQLAULT-UHFFFAOYSA-N 271503 US10065941, Compound I-004::US9732060, Compound I-004 P2X purinoceptor 3 Homo sapiens 14.0 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271503 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271503&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752187 378153331 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655344 CC(C)(Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(F)cn3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O InChI=1S/C26H23ClFN5O5/c1-26(2,22(34)35)15-33-24(36)31-23(32(25(33)37)14-16-3-5-17(27)6-4-16)30-19-8-10-20(11-9-19)38-21-12-7-18(28)13-29-21/h3-13H,14-15H2,1-2H3,(H,34,35)(H,30,31,36) DEUOHZRZNWVIJH-UHFFFAOYSA-N 271504 US10065941, Compound I-005::US9732060, Compound I-005 P2X purinoceptor 3 Homo sapiens 8.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271504 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271504&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752167 378153332 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655345 CC(C)(Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(Cl)cn3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O InChI=1S/C26H23Cl2N5O5/c1-26(2,22(34)35)15-33-24(36)31-23(32(25(33)37)14-16-3-5-17(27)6-4-16)30-19-8-10-20(11-9-19)38-21-12-7-18(28)13-29-21/h3-13H,14-15H2,1-2H3,(H,34,35)(H,30,31,36) UXDHDBKZQYVJSB-UHFFFAOYSA-N 271505 US10065941, Compound I-006::US9732060, Compound I-006 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271505 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271505&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752326 378153333 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655346 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ncccc3F)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C27H25ClFN5O5/c1-27(2,23(35)38-3)16-34-25(36)32-24(33(26(34)37)15-17-6-8-18(28)9-7-17)31-19-10-12-20(13-11-19)39-22-21(29)5-4-14-30-22/h4-14H,15-16H2,1-3H3,(H,31,32,36) JZFORMIPMPCUTA-UHFFFAOYSA-N 271506 US10065941, Compound I-007::US9732060, Compound I-007 P2X purinoceptor 3 Homo sapiens 9.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271506 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271506&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752318 378153334 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 655347 COC(=O)C(C)(C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(F)n3)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C27H25ClFN5O5/c1-27(2,23(35)38-3)16-34-25(36)32-24(33(26(34)37)15-17-7-9-18(28)10-8-17)30-19-11-13-20(14-12-19)39-22-6-4-5-21(29)31-22/h4-14H,15-16H2,1-3H3,(H,30,32,36) DSIJTPSJCQDTAN-UHFFFAOYSA-N 271507 US10065941, Compound I-008::US9732060, Compound I-008 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2ZC8506 aid1796965 US9732060 Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271507 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271507&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752315 378153335 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 682929 CC(NC(=O)c1cc(OC[C@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ncc(Cl)cc1F InChI=1S/C23H23ClFN3O3S/c1-13-9-27-23(32-13)17-5-16(6-19(7-17)31-12-15-3-4-30-11-15)22(29)28-14(2)21-20(25)8-18(24)10-26-21/h5-10,14-15H,3-4,11-12H2,1-2H3,(H,28,29)/t14?,15-/m0/s1 NHGFOVVSFOISFI-LOACHALJSA-N 319898 N-[1-(5- Chloro-3- fluoropyridin- 2-yl)ethyl]-3- (5-methyL- 1,3-thiazol-2- yl)-5-[(3S)- tetrahydrofuran- 3-ylmethoxy] benzamide::US10174016, Example 65::US10202369, Example 65::US10472354, Example 65 P2X purinoceptor 3 Homo sapiens 3.00 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319898 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319898&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397187 384223178 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 682931 Cc1cnc(s1)-c1cc(OC[C@H]2CCOC2)cc(c1)C(=O)NCc1ccc(C)nn1 InChI=1S/C22H24N4O3S/c1-14-3-4-19(26-25-14)11-23-21(27)17-7-18(22-24-10-15(2)30-22)9-20(8-17)29-13-16-5-6-28-12-16/h3-4,7-10,16H,5-6,11-13H2,1-2H3,(H,23,27)/t16-/m0/s1 SKNHRCMFBDROGE-INIZCTEOSA-N 319899 N-[(6- Methylpyridazin- 3-yl)methyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5-[(3S)- tetrahydrofuran- 3-ylmethoxy] benzamide::US10174016, Example 66::US10202369, Example 66::US10472354, Example 66 P2X purinoceptor 3 Homo sapiens 35.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319899 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319899&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397153 384223179 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 682933 Cc1cnc(s1)-c1cc(OC[C@H]2CCOC2)cc(c1)C(=O)NCc1cnc(C)cn1 InChI=1S/C22H24N4O3S/c1-14-8-24-19(10-23-14)11-25-21(27)17-5-18(22-26-9-15(2)30-22)7-20(6-17)29-13-16-3-4-28-12-16/h5-10,16H,3-4,11-13H2,1-2H3,(H,25,27)/t16-/m0/s1 MFTNZVDLSIJVDH-INIZCTEOSA-N 319900 N-[(5- Methylpyrazin- 2-yl)methyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5-[(3S)- tetrahydrofuran- 3-ylmethoxy] benzamide::US10174016, Example 67::US10202369, Example 67::US10472354, Example 67 P2X purinoceptor 3 Homo sapiens 186 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319900 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319900&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397127 384223180 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 682935 C[C@@H](NC(=O)c1cc(OC[C@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1cnc(C)cn1 InChI=1S/C23H26N4O3S/c1-14-9-25-21(11-24-14)16(3)27-22(28)18-6-19(23-26-10-15(2)31-23)8-20(7-18)30-13-17-4-5-29-12-17/h6-11,16-17H,4-5,12-13H2,1-3H3,(H,27,28)/t16-,17+/m1/s1 VCKXOWQZUNTNDF-SJORKVTESA-N 319901 N-[(1R)-1-(5- Methylpyrazin- 2-yl)ethyl]- 3-(5-methyl- 1,3-thiazol-2- yl)-5-[(3S)- tetrahydrofuran- 3-ylmethoxy] benzamide::US10174016, Example 68::US10202369, Example 68::US10472354, Example 68 P2X purinoceptor 3 Homo sapiens 44.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319901 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319901&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397617 384223181 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 682937 CC(NC(=O)c1cc(OC[C@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ncc(F)cc1Cl InChI=1S/C23H23ClFN3O3S/c1-13-9-27-23(32-13)17-5-16(6-19(7-17)31-12-15-3-4-30-11-15)22(29)28-14(2)21-20(24)8-18(25)10-26-21/h5-10,14-15H,3-4,11-12H2,1-2H3,(H,28,29)/t14?,15-/m0/s1 UNHVUPCUCRZLRC-LOACHALJSA-N 319902 N-[1-(3- Chloro-5- fluoropyridin- 2-yl)ethyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5-[(3R)- tetrahydrofuran- 3-ylmethoxy] benzamide::US10174016, Example 69::US10202369, Example 69::US10472354, Example 69 P2X purinoceptor 3 Homo sapiens 15.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319902 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319902&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134338444 384223182 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 682939 C[C@@H](NC(=O)c1cc(OC[C@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H23F3N4O3S/c1-13-8-27-21(34-13)17-5-16(6-19(7-17)33-12-15-3-4-32-11-15)20(31)30-14(2)18-9-28-22(29-10-18)23(24,25)26/h5-10,14-15H,3-4,11-12H2,1-2H3,(H,30,31)/t14-,15+/m1/s1 CHPCVIFXIKJNGF-CABCVRRESA-N 319903 3-(5-Methyl- 1,3-thiazol-2- yl)-5-[(3S)- tetrahydrofuran- 3-ylmethoxy]- N-[(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl] benzamide::US10174016, Example 70::US10202369, Example 70::US10472354, Example 70 P2X purinoceptor 3 Homo sapiens 3.00 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319903 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319903&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397748 384223183 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 682941 C[C@@H](NC(=O)c1cc(OC[C@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ccc(C)nn1 InChI=1S/C23H26N4O3S/c1-14-4-5-21(27-26-14)16(3)25-22(28)18-8-19(23-24-11-15(2)31-23)10-20(9-18)30-13-17-6-7-29-12-17/h4-5,8-11,16-17H,6-7,12-13H2,1-3H3,(H,25,28)/t16-,17+/m1/s1 DJBMUKYGNBBQBO-SJORKVTESA-N 319904 N-[(1R)-1-(6- Methylpyridazin- 3-yl)ethyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5-[(3S)- tetrahydrofuran- 3-ylmethoxy] benzamide::US10174016, Example 71::US10202369, Example 71::US10472354, Example 71 P2X purinoceptor 3 Homo sapiens 15.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319904 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319904&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397305 384223184 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 682943 C[C@@H](NC(=O)c1cc(OC[C@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F InChI=1S/C23H23F3N4O3S/c1-13-10-27-22(34-13)17-7-16(8-18(9-17)33-12-15-5-6-32-11-15)21(31)28-14(2)19-3-4-20(30-29-19)23(24,25)26/h3-4,7-10,14-15H,5-6,11-12H2,1-2H3,(H,28,31)/t14-,15+/m1/s1 BICIIZABCQYPPY-CABCVRRESA-N 319905 3-(5-Methyl- 1,3-thiazol-2- yl)-5-[(3S)- tetrahydrofuran- 3-ylmethoxy]- N-[(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl] benzamide::US10174016, Example 72::US10202369, Example 72::US10472354, Example 72 P2X purinoceptor 3 Homo sapiens 11.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319905 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319905&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397781 384223185 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 682945 C[C@@H](NC(=O)c1cc(OC[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H23F3N4O3S/c1-13-8-27-21(34-13)17-5-16(6-19(7-17)33-12-15-3-4-32-11-15)20(31)30-14(2)18-9-28-22(29-10-18)23(24,25)26/h5-10,14-15H,3-4,11-12H2,1-2H3,(H,30,31)/t14-,15-/m1/s1 CHPCVIFXIKJNGF-HUUCEWRRSA-N 319906 3-(5-Methyl- 1,3-thiazol-2- yl)-5-[(3R)- tetrahydrofuran- 3-ylmethoxy]- N-[(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl] benzamide::US10174016, Example 73::US10202369, Example 73::US10472354, Example 73 P2X purinoceptor 3 Homo sapiens 4.00 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319906 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319906&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397238 384223186 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 682947 C[C@@H](NC(=O)c1cc(OC[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1cnc(C)cn1 InChI=1S/C23H26N4O3S/c1-14-9-25-21(11-24-14)16(3)27-22(28)18-6-19(23-26-10-15(2)31-23)8-20(7-18)30-13-17-4-5-29-12-17/h6-11,16-17H,4-5,12-13H2,1-3H3,(H,27,28)/t16-,17-/m1/s1 VCKXOWQZUNTNDF-IAGOWNOFSA-N 319907 N-[(1R)-1-(5- Methylpyrazin- 2-yl)ethyl]- 3-(5-methyl- 1,3-thiazol-2- yl)-5-[(3R)- tetrahydrofuran- 3-ylmethoxy] benzamide::US10174016, Example 74::US10202369, Example 74::US10472354, Example 74 P2X purinoceptor 3 Homo sapiens 14.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319907 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319907&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397532 384223187 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 682949 Cc1cnc(s1)-c1cc(OC[C@@H]2CCOC2)cc(c1)C(=O)NCc1ccc(C)nn1 InChI=1S/C22H24N4O3S/c1-14-3-4-19(26-25-14)11-23-21(27)17-7-18(22-24-10-15(2)30-22)9-20(8-17)29-13-16-5-6-28-12-16/h3-4,7-10,16H,5-6,11-13H2,1-2H3,(H,23,27)/t16-/m1/s1 SKNHRCMFBDROGE-MRXNPFEDSA-N 319908 N-[(6- Methylpyridazin- 3-yl)methyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5-[(3R)- tetrahydrofuran- 3-ylmethoxy] benzamide::US10174016, Example 75::US10202369, Example 75::US10472354, Example 75 P2X purinoceptor 3 Homo sapiens 38.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319908 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319908&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397221 384223188 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 682951 Cc1cnc(s1)-c1cc(OC[C@@H]2CCOC2)cc(c1)C(=O)NCc1cnc(C)cn1 InChI=1S/C22H24N4O3S/c1-14-8-24-19(10-23-14)11-25-21(27)17-5-18(22-26-9-15(2)30-22)7-20(6-17)29-13-16-3-4-28-12-16/h5-10,16H,3-4,11-13H2,1-2H3,(H,25,27)/t16-/m1/s1 MFTNZVDLSIJVDH-MRXNPFEDSA-N 319909 N-[(5- Methylpyrazin- 2-yl)methyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5-[(3R)- tetrahydrofuran- 3-ylmethoxy] benzamide::US10174016, Example 76::US10202369, Example 76::US10472354, Example 76 P2X purinoceptor 3 Homo sapiens 201 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319909 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319909&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397850 384223189 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 682953 C[C@@H](NC(=O)c1cc(OC[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ccc(C)nn1 InChI=1S/C23H26N4O3S/c1-14-4-5-21(27-26-14)16(3)25-22(28)18-8-19(23-24-11-15(2)31-23)10-20(9-18)30-13-17-6-7-29-12-17/h4-5,8-11,16-17H,6-7,12-13H2,1-3H3,(H,25,28)/t16-,17-/m1/s1 DJBMUKYGNBBQBO-IAGOWNOFSA-N 319910 N-[(1R)-1-(6- Methylpyridazin- 3-yl)ethyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5-[(3R)- tetrahydrofuran- 3-ylmethoxy] benzomide::US10174016, Example 77::US10202369, Example 77::US10472354, Example 77 P2X purinoceptor 3 Homo sapiens 10.00 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319910 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319910&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397806 384223190 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 682955 CC(NC(=O)c1cc(OC[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ncc(Cl)cc1F InChI=1S/C23H23ClFN3O3S/c1-13-9-27-23(32-13)17-5-16(6-19(7-17)31-12-15-3-4-30-11-15)22(29)28-14(2)21-20(25)8-18(24)10-26-21/h5-10,14-15H,3-4,11-12H2,1-2H3,(H,28,29)/t14?,15-/m1/s1 NHGFOVVSFOISFI-YSSOQSIOSA-N 319911 N-[1-(5- Chloro-3- fluoropyridin- 2-yl)ethyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5-[(3R)- tetrahydrofuran- 3-ylmethoxy] benzamide::US10174016, Example 78::US10202369, Example 78::US10472354, Example 78 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319911 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319911&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397720 384223191 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 682957 C[C@@H](NC(=O)c1cc(OC[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F InChI=1S/C23H23F3N4O3S/c1-13-10-27-22(34-13)17-7-16(8-18(9-17)33-12-15-5-6-32-11-15)21(31)28-14(2)19-3-4-20(30-29-19)23(24,25)26/h3-4,7-10,14-15H,5-6,11-12H2,1-2H3,(H,28,31)/t14-,15-/m1/s1 BICIIZABCQYPPY-HUUCEWRRSA-N 319912 3-(5-Methyl- 1,3-thiazol-2- yl)-5-[(3R)- tetrahydrofuran- 3-ylmethoxy]- N-[(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl] benzamide::US10174016, Example 79::US10202369, Example 79::US10472354, Example 79 P2X purinoceptor 3 Homo sapiens 9.00 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319912 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319912&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397596 384223192 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 682959 CC(NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(C)s1)c1ncc(F)cc1Cl InChI=1S/C23H23ClFN3O3S/c1-13-11-27-23(32-13)16-7-15(8-19(9-16)31-18-3-5-30-6-4-18)22(29)28-14(2)21-20(24)10-17(25)12-26-21/h7-12,14,18H,3-6H2,1-2H3,(H,28,29) SBZIYANVWYKJKX-UHFFFAOYSA-N 319913 N-[1-(3- Chloro-5- fluoropyridin- 2-yl)ethyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5- (tetrahydro- 2H-pyran-4- yloxy) benzamide::US10174016, Example 80::US10202369, Example 80::US10472354, Example 80 P2X purinoceptor 3 Homo sapiens 12.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319913 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319913&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397324 384223193 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 682961 CC(NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(C)s1)c1ncc(Cl)cc1F InChI=1S/C23H23ClFN3O3S/c1-13-11-27-23(32-13)16-7-15(8-19(9-16)31-18-3-5-30-6-4-18)22(29)28-14(2)21-20(25)10-17(24)12-26-21/h7-12,14,18H,3-6H2,1-2H3,(H,28,29) UXQVDYSQMZTJPS-UHFFFAOYSA-N 319914 N-[1-(5- Chloro-3- fluoropyridin- 2-yl)ethyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5- (tetrahydro- 2H-pyran-4- yloxy) benzamide::US10174016, Example 81::US10202369, Example 81::US10472354, Example 81 P2X purinoceptor 3 Homo sapiens 3.00 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319914 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319914&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397622 384223194 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 682963 Cc1cnc(s1)-c1cc(OC2CCOCC2)cc(c1)C(=O)NCc1ccc(C)nn1 InChI=1S/C22H24N4O3S/c1-14-3-4-18(26-25-14)13-23-21(27)16-9-17(22-24-12-15(2)30-22)11-20(10-16)29-19-5-7-28-8-6-19/h3-4,9-12,19H,5-8,13H2,1-2H3,(H,23,27) LSYGQIAUTJTZDJ-UHFFFAOYSA-N 319915 N-[(6- Methylpyridazin- 3-yl)methyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5- (tetrahydro- 2H-pyran-4- yloxy) benzamide::US10174016, Example 82::US10202369, Example 82::US10472354, Example 82 P2X purinoceptor 3 Homo sapiens 28.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319915 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319915&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397341 384223195 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 682965 Cc1cnc(s1)-c1cc(OC2CCOCC2)cc(c1)C(=O)NCc1cnc(C)cn1 InChI=1S/C22H24N4O3S/c1-14-10-24-18(12-23-14)13-25-21(27)16-7-17(22-26-11-15(2)30-22)9-20(8-16)29-19-3-5-28-6-4-19/h7-12,19H,3-6,13H2,1-2H3,(H,25,27) YXUSESJBYZNMQE-UHFFFAOYSA-N 319916 N-[(5- Methylpyrazin- 2-yl)methyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5- (tetrahydro- 2H-pyran-4- yloxy) benzamide::US10174016, Example 83::US10202369, Example 83::US10472354, Example 83 P2X purinoceptor 3 Homo sapiens 125 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319916 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319916&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397170 384223196 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 682967 C[C@@H](NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(C)s1)c1cnc(C)cn1 InChI=1S/C23H26N4O3S/c1-14-11-25-21(13-24-14)16(3)27-22(28)17-8-18(23-26-12-15(2)31-23)10-20(9-17)30-19-4-6-29-7-5-19/h8-13,16,19H,4-7H2,1-3H3,(H,27,28)/t16-/m1/s1 USCQOVGUOPYDKF-MRXNPFEDSA-N 319917 N-[(1R)-1-(5- Methylpyrazin- 2-yl)ethyl]- 3-(5-methyl- 1,3-thiazol-2- yl)-5- (tetrahydro- 2H-pyran-4- yloxy) benzamide::US10174016, Example 84::US10202369, Example 84::US10472354, Example 84 P2X purinoceptor 3 Homo sapiens 26.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319917 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319917&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397618 384223197 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 682969 C[C@@H](NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H23F3N4O3S/c1-13-10-27-21(34-13)16-7-15(8-19(9-16)33-18-3-5-32-6-4-18)20(31)30-14(2)17-11-28-22(29-12-17)23(24,25)26/h7-12,14,18H,3-6H2,1-2H3,(H,30,31)/t14-/m1/s1 WGQQHPGXKFPPTQ-CQSZACIVSA-N 319918 3-(5-Methyl- 1,3-thiazol-2- yl)-5- (tetrahydro- 2H-pyran-4- yloxy)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 85::US10202369, Example 85::US10472354, Example 85 P2X purinoceptor 3 Homo sapiens 10.00 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319918 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319918&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397801 384223198 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 682971 COc1ccc(cn1)[C@@H](C)NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(C)s1 InChI=1S/C24H27N3O4S/c1-15-13-26-24(32-15)19-10-18(11-21(12-19)31-20-6-8-30-9-7-20)23(28)27-16(2)17-4-5-22(29-3)25-14-17/h4-5,10-14,16,20H,6-9H2,1-3H3,(H,27,28)/t16-/m1/s1 HOSIWEZQKWEZJW-MRXNPFEDSA-N 319919 N-[(1R)-1-(6- Methoxypyridin- 3-yl)ethyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5- (tetrahydro- 2H-pyran-4- yloxy) benzamide::US10174016, Example 86::US10202369, Example 86::US10472354, Example 86 P2X purinoceptor 3 Homo sapiens 12.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319919 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319919&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397310 384223199 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 682973 C[C@@H](NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(C)s1)c1ccc(C)nn1 InChI=1S/C23H26N4O3S/c1-14-4-5-21(27-26-14)16(3)25-22(28)17-10-18(23-24-13-15(2)31-23)12-20(11-17)30-19-6-8-29-9-7-19/h4-5,10-13,16,19H,6-9H2,1-3H3,(H,25,28)/t16-/m1/s1 OIHQARAAGWIFBW-MRXNPFEDSA-N 319920 N-[(1R)-1-(6- Methylpyridazin- 3-yl)ethyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5- (tetrahydro- 2H-pyran-4- yloxy) benzamide::US10174016, Example 87::US10202369, Example 87::US10472354, Example 87 P2X purinoceptor 3 Homo sapiens 15.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319920 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319920&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397290 384223200 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 682975 COc1ccc(CNC(=O)c2cc(OC3CCOCC3)cc(c2)-c2ncc(C)s2)nn1 InChI=1S/C22H24N4O4S/c1-14-12-24-22(31-14)16-9-15(10-19(11-16)30-18-5-7-29-8-6-18)21(27)23-13-17-3-4-20(28-2)26-25-17/h3-4,9-12,18H,5-8,13H2,1-2H3,(H,23,27) FUPOQWQPMIFATK-UHFFFAOYSA-N 319921 N-[(6- Methoxy- pyridazin-3- yl)methyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5- (tetrahydro- 2H-pyran-4- yloxy) benzamide::US10174016, Example 88::US10202369, Example 88::US10472354, Example 88 P2X purinoceptor 3 Homo sapiens 30.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319921 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319921&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397556 384223201 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 682977 C[C@@H](NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F InChI=1S/C23H23F3N4O3S/c1-13-12-27-22(34-13)16-9-15(10-18(11-16)33-17-5-7-32-8-6-17)21(31)28-14(2)19-3-4-20(30-29-19)23(24,25)26/h3-4,9-12,14,17H,5-8H2,1-2H3,(H,28,31)/t14-/m1/s1 RJKHHNIHJKFMMR-CQSZACIVSA-N 319922 3-(5-Methyl- 1,3-thiazol-2- yl)-5- (tetrahydro- 2H-pyran-4- yloxy)-N- {(1R)-1-[6- (trifluoromethyl) pyridazin- 3-yl]ethyl} benzamide::US10174016, Example 89::US10202369, Example 89::US10472354, Example 89 P2X purinoceptor 3 Homo sapiens 11.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319922 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319922&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397595 384223202 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 682979 CC[C@@H](NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H25F3N4O3S/c1-3-20(17-12-29-23(30-13-17)24(25,26)27)31-21(32)15-8-16(22-28-11-14(2)35-22)10-19(9-15)34-18-4-6-33-7-5-18/h8-13,18,20H,3-7H2,1-2H3,(H,31,32)/t20-/m1/s1 ULSBLOPPTNALIT-HXUWFJFHSA-N 319923 3-(5-Methyl- 1,3-thiazol-2- yl)-5- (tetrahydro- 2H-pyran-4- yloxy)-N-{(1R)- 1-[2- (trifluorometh- yl)pyrimidin-5- yl]propyl}benz- amide::US10174016, Example 90::US10202369, Example 90::US10472354, Example 90 P2X purinoceptor 3 Homo sapiens 111 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319923 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319923&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397769 384223203 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 682981 C[C@@H](NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(C)s1)c1ccc(C)nc1 InChI=1S/C24H27N3O3S/c1-15-4-5-18(14-25-15)17(3)27-23(28)19-10-20(24-26-13-16(2)31-24)12-22(11-19)30-21-6-8-29-9-7-21/h4-5,10-14,17,21H,6-9H2,1-3H3,(H,27,28)/t17-/m1/s1 VKTBTGUHIBZLBJ-QGZVFWFLSA-N 319924 N-[(1R)-1-(6- Methylpyridin- 3-yl)ethyl]-3- (5-methyl-1,3- thiazol-2-yl)-5- (tetrahydro- 2H-pyran-4- yloxy)benzamide::US10174016, Example 91::US10202369, Example 91::US10472354, Example 91 P2X purinoceptor 3 Homo sapiens 19.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319924 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319924&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397502 384223204 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 682983 C[C@@H](NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(C)s1)c1nnc(C)s1 InChI=1S/C21H24N4O3S2/c1-12-11-22-21(29-12)16-8-15(9-18(10-16)28-17-4-6-27-7-5-17)19(26)23-13(2)20-25-24-14(3)30-20/h8-11,13,17H,4-7H2,1-3H3,(H,23,26)/t13-/m1/s1 GHXRECQLMZGPIV-CYBMUJFWSA-N 319925 N-[(1R)-1-(5- Methyl-1,3,4- thiadiazol-2- yl)ethyl]-3-(5- methyl-1,3- thiazol-2-yl)-5- (tetrahydro- 2H-pyran-4- yloxy)benzamide::US10174016, Example 92::US10202369, Example 92::US10472354, Example 92 P2X purinoceptor 3 Homo sapiens 24.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319925 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319925&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397542 384223205 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 682985 Cc1cnc(s1)-c1cc(OCC2CCOCC2)cc(c1)C(=O)NCc1ccc(C)nn1 InChI=1S/C23H26N4O3S/c1-15-3-4-20(27-26-15)13-24-22(28)18-9-19(23-25-12-16(2)31-23)11-21(10-18)30-14-17-5-7-29-8-6-17/h3-4,9-12,17H,5-8,13-14H2,1-2H3,(H,24,28) QOXIPNMWVVZPOQ-UHFFFAOYSA-N 319926 N-[(6- Methyl- pyridazin-3- yl)methyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5- (tetrahydro- 2H-pyran-4- ylmethoxy) benzamide::US10174016, Example 93::US10202369, Example 93::US10472354, Example 93 P2X purinoceptor 3 Homo sapiens 8.00 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319926 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319926&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397788 384223206 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 682987 C[C@@H](NC(=O)c1cc(OCC2CCOCC2)cc(c1)-c1ncc(C)s1)c1cnc(C)cn1 InChI=1S/C24H28N4O3S/c1-15-11-26-22(13-25-15)17(3)28-23(29)19-8-20(24-27-12-16(2)32-24)10-21(9-19)31-14-18-4-6-30-7-5-18/h8-13,17-18H,4-7,14H2,1-3H3,(H,28,29)/t17-/m1/s1 HCAZTDIYUNBLAC-QGZVFWFLSA-N 319927 N-[(1R)-1-(5- Methylpyrazin- 2-yl)ethyl]- 3-(5-methyl- 1,3-thiazol-2- yl)-5- (tetrahydro- 2H-pyran-4- ylmethoxy) benzamide::US10174016, Example 94::US10202369, Example 94::US10472354, Example 94 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319927 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319927&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397604 384223207 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 682989 CC(NC(=O)c1cc(OCC2CCOCC2)cc(c1)-c1ncc(C)s1)c1ncc(Cl)cc1F InChI=1S/C24H25ClFN3O3S/c1-14-11-28-24(33-14)18-7-17(8-20(9-18)32-13-16-3-5-31-6-4-16)23(30)29-15(2)22-21(26)10-19(25)12-27-22/h7-12,15-16H,3-6,13H2,1-2H3,(H,29,30) WLBXKEKEIMKGRV-UHFFFAOYSA-N 319928 N-[1-(5- Chloro-3- fluoropyridin- 2-yl)ethyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5- (tetrahydro- 2H-pyran--4- ylmethoxy) benzamide::US10174016, Example 95::US10202369, Example 95::US10472354, Example 95 P2X purinoceptor 3 Homo sapiens 2.00 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319928 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319928&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397656 384223208 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 682991 CC(NC(=O)c1cc(OCC2CCOCC2)cc(c1)-c1ncc(C)s1)c1ncc(F)cc1Cl InChI=1S/C24H25ClFN3O3S/c1-14-11-28-24(33-14)18-7-17(8-20(9-18)32-13-16-3-5-31-6-4-16)23(30)29-15(2)22-21(25)10-19(26)12-27-22/h7-12,15-16H,3-6,13H2,1-2H3,(H,29,30) YAVBCOZWMZVERS-UHFFFAOYSA-N 319929 N-[1-(3- Chloro-5- fluoropyridin- 2-yl)ethyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5- (tetrahydro- 2H-pyran-4- ylmethoxy) benzamide::US10174016, Example 96::US10202369, Example 96::US10472354, Example 96 P2X purinoceptor 3 Homo sapiens 18.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319929 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319929&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397482 384223209 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 682993 Cc1cnc(s1)-c1cc(OCC2CCOCC2)cc(c1)C(=O)NCc1cnc(C)cn1 InChI=1S/C23H26N4O3S/c1-15-10-25-20(12-24-15)13-26-22(28)18-7-19(23-27-11-16(2)31-23)9-21(8-18)30-14-17-3-5-29-6-4-17/h7-12,17H,3-6,13-14H2,1-2H3,(H,26,28) VSGRXICPAXTBHX-UHFFFAOYSA-N 319930 N-[(5- Methylpyrazin- 2- yl)methyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5- (tetrahydro- 2H-pyran-4- ylmethoxy) benzamide::US10174016, Example 97::US10202369, Example 97::US10472354, Example 97 P2X purinoceptor 3 Homo sapiens 15.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319930 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319930&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397814 384223210 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683523 C[C@@H](NC(=O)c1cc(OC[C@@H]2COCCN2C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H26F3N5O3S/c1-14-9-28-22(36-14)17-6-16(7-20(8-17)35-13-19-12-34-5-4-32(19)3)21(33)31-15(2)18-10-29-23(30-11-18)24(25,26)27/h6-11,15,19H,4-5,12-13H2,1-3H3,(H,31,33)/t15-,19+/m1/s1 QQIYVSYWBHUFSE-BEFAXECRSA-N 320195 3-{[(3S)-4- methylmorpholin- 3- yl]methoxy}-5- (5-methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyridin-5- yl]ethyl} benzamide::US10174016, Example 362::US10202369, Example 362::US10472354, Example 362 P2X purinoceptor 3 Homo sapiens 8.00 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320195 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320195&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397415 384223468 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683525 C[C@@H](NC(=O)c1cc(OC[C@H]2COCCN2C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H26F3N5O3S/c1-14-9-28-22(36-14)17-6-16(7-20(8-17)35-13-19-12-34-5-4-32(19)3)21(33)31-15(2)18-10-29-23(30-11-18)24(25,26)27/h6-11,15,19H,4-5,12-13H2,1-3H3,(H,31,33)/t15-,19-/m1/s1 QQIYVSYWBHUFSE-DNVCBOLYSA-N 320193 3-{[(3R)-4-methylmorpholin-3-yl]methoxyl}-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 360::US10202369, Example 360::US10472354, Example 360 P2X purinoceptor 3 Homo sapiens 12.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320193 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320193&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397664 384223466 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683527 C[C@@H](NC(=O)c1cc(OCC2CC(F)CN2C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H25F4N5O2S/c1-13-8-29-22(36-13)16-4-15(5-20(6-16)35-12-19-7-18(25)11-33(19)3)21(34)32-14(2)17-9-30-23(31-10-17)24(26,27)28/h4-6,8-10,14,18-19H,7,11-12H2,1-3H3,(H,32,34)/t14-,18?,19?/m1/s1 UCQIVXMFKURDDU-FTXHTYHOSA-N 320197 3-{[4-fluoro-1- methylpyrrolidin- 2- yl]methoxy}-5- (5-methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide, as a mixture of stereoisomers::US10174016, Example 364::US10202369, Example 364::US10472354, Example 364 P2X purinoceptor 3 Homo sapiens 16.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320197 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320197&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397240 384223470 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683529 C[C@@H](NC(=O)c1cc(OCC2CC(F)CN2C)cc(c1)-c1ncc(C)s1)c1ccc(nc1)C(F)(F)F InChI=1S/C25H26F4N4O2S/c1-14-10-31-24(36-14)18-6-17(7-21(8-18)35-13-20-9-19(26)12-33(20)3)23(34)32-15(2)16-4-5-22(30-11-16)25(27,28)29/h4-8,10-11,15,19-20H,9,12-13H2,1-3H3,(H,32,34)/t15-,19?,20?/m1/s1 XNRRWTQJTXNPEU-APMMTJHUSA-N 320198 3-{[4-fluoro-1- methylpyrrolidin- 2- yl]methoxy}-5- (5-methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[6- (trifluoromethyl) pyridin-3- yl]ethyl} benzamide, as a mixture of stereoisomers::US10174016, Example 365::US10202369, Example 365::US10472354, Example 365 P2X purinoceptor 3 Homo sapiens 21.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320198 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320198&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397581 384223471 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683531 C[C@@H](NC(=O)c1cc(OC[C@H]2CN(C)CCO2)cc(c1)-c1ncc(C)s1)c1ccc(nc1)C(F)(F)F InChI=1S/C25H27F3N4O3S/c1-15-11-30-24(36-15)19-8-18(9-20(10-19)35-14-21-13-32(3)6-7-34-21)23(33)31-16(2)17-4-5-22(29-12-17)25(26,27)28/h4-5,8-12,16,21H,6-7,13-14H2,1-3H3,(H,31,33)/t16-,21-/m1/s1 PQZKBUDIGDWISA-IIBYNOLFSA-N 320199 3-{[(2R)-4-methylmorpholin-2-yl]methoxyl}-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[6-(trifluoromethyl)pyridin-3-yl]ethyl}benzamide::US10174016, Example 366::US10202369, Example 366::US10472354, Example 366 P2X purinoceptor 3 Homo sapiens 18.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320199 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320199&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397655 384223472 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683533 C[C@@H](NC(=O)c1cc(OC[C@H]2CN(C)CCO2)cc(c1)-c1ncc(Cl)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H23ClF3N5O3S/c1-13(16-8-29-22(30-9-16)23(25,26)27)31-20(33)14-5-15(21-28-10-19(24)36-21)7-17(6-14)35-12-18-11-32(2)3-4-34-18/h5-10,13,18H,3-4,11-12H2,1-2H3,(H,31,33)/t13-,18-/m1/s1 AJIHXKQJGQMCEX-FZKQIMNGSA-N 320200 3-(5-chloro- 1,3-thiazol-2- yl)-5-{[(2R)-4- methylmorpholin- 2-yl]methoxy}-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5-yl] ethyl}benzamide::US10174016, Example 367::US10202369, Example 367::US10472354, Example 367 P2X purinoceptor 3 Homo sapiens 13.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320200 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320200&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397149 384223473 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683535 CN1CCO[C@H](COc2cc(cc(c2)-c2ncc(C)s2)C(=O)NCc2cnc(nc2)C(F)(F)F)C1 InChI=1S/C23H24F3N5O3S/c1-14-8-28-21(35-14)17-5-16(6-18(7-17)34-13-19-12-31(2)3-4-33-19)20(32)27-9-15-10-29-22(30-11-15)23(24,25)26/h5-8,10-11,19H,3-4,9,12-13H2,1-2H3,(H,27,32)/t19-/m0/s1 VTYFKUULJMRVCQ-IBGZPJMESA-N 320201 3-{[(2S)-4- methylmorpholin- 2-yl]methoxy}-5- (5-methyl-1,3- thiazol-2-yl)- N-{[2- (trifluoromethyl) pyrimidin-5-yl] methyl} benzamide::US10174016, Example 368::US10202369, Example 368::US10472354, Example 368 P2X purinoceptor 3 Homo sapiens 84.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320201 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320201&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397462 384223474 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683537 C[C@@H](NC(=O)c1cc(OC[C@H]2CN(C)CCO2)cc(c1)-c1ncc(C)s1)c1ccc(nc1)C(F)F InChI=1S/C25H28F2N4O3S/c1-15-11-29-25(35-15)19-8-18(9-20(10-19)34-14-21-13-31(3)6-7-33-21)24(32)30-16(2)17-4-5-22(23(26)27)28-12-17/h4-5,8-12,16,21,23H,6-7,13-14H2,1-3H3,(H,30,32)/t16-,21-/m1/s1 YEIOEBIHIRXRPN-IIBYNOLFSA-N 320202 N-{(1R)-1-[6- (difluoromethyl) pyridin-3- yl]ethyl}-3- {[(2R)-4- methylmorpholin- 2-yl]methoxy}-5- (5-methyl-1,3- thiazol-2- yl)benzamide::US10174016, Example 369::US10202369, Example 369::US10472354, Example 369 P2X purinoceptor 3 Homo sapiens 11.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320202 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320202&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397220 384223475 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683539 C[C@@H](NC(=O)c1cc(OC[C@@H]2CN(C)CCO2)cc(c1)-c1ncc(C)s1)c1ccc(nc1)C(F)(F)F InChI=1S/C25H27F3N4O3S/c1-15-11-30-24(36-15)19-8-18(9-20(10-19)35-14-21-13-32(3)6-7-34-21)23(33)31-16(2)17-4-5-22(29-12-17)25(26,27)28/h4-5,8-12,16,21H,6-7,13-14H2,1-3H3,(H,31,33)/t16-,21+/m1/s1 PQZKBUDIGDWISA-IERDGZPVSA-N 320203 3-{[(2S)-4- methylmorpholin 2-yl]methoxy}-5- (5-methyl-1,3- thiazol-2-yl)- N-{(1R)-1-[6- (trifluoromethyl) pyridin-3- yl]ethyl} benzamide::US10174016, Example 370::US10202369, Example 370::US10472354, Example 370 P2X purinoceptor 3 Homo sapiens 41.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320203 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320203&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397778 384223476 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683541 C[C@@H](NC(=O)c1cc(OCC2(F)CN(C)C2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H23F4N5O2S/c1-13-7-28-20(35-13)16-4-15(5-18(6-16)34-12-22(24)10-32(3)11-22)19(33)31-14(2)17-8-29-21(30-9-17)23(25,26)27/h4-9,14H,10-12H2,1-3H3,(H,31,33)/t14-/m1/s1 UHPSIXSPUGVYFA-CQSZACIVSA-N 320204 3-[(3-fluoro-1- methylazetidin-3- yl}methoxy]-5- (5-methyl-1,3- thiazol-2-yl)- N-{(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 371::US10202369, Example 371::US10472354, Example 371 P2X purinoceptor 3 Homo sapiens 24.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320204 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320204&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397234 384223477 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683543 CN1CCO[C@@H](COc2cc(cc(c2)-c2ncc(C)s2)C(=O)NCc2cnc(nc2)C(F)(F)F)C1 InChI=1S/C23H24F3N5O3S/c1-14-8-28-21(35-14)17-5-16(6-18(7-17)34-13-19-12-31(2)3-4-33-19)20(32)27-9-15-10-29-22(30-11-15)23(24,25)26/h5-8,10-11,19H,3-4,9,12-13H2,1-2H3,(H,27,32)/t19-/m1/s1 VTYFKUULJMRVCQ-LJQANCHMSA-N 320205 3-{[(2R)-4- methylmorpholin- 2-yl]methoxy}-5- (5-methyl-1,3- thiazol-2-yl)- N-{[2- (trifluoromethyl) pyrimidin-5-yl] methyl} benzamide::US10174016, Example 372::US10202369, Example 372::US10472354, Example 372 P2X purinoceptor 3 Homo sapiens 19.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320205 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320205&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397797 384223478 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683545 C[C@@H](NC(=O)c1cc(OC[C@H]2CN(C)CCO2)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F InChI=1S/C24H26F3N5O3S/c1-14-11-28-23(36-14)17-8-16(9-18(10-17)35-13-19-12-32(3)6-7-34-19)22(33)29-15(2)20-4-5-21(31-30-20)24(25,26)27/h4-5,8-11,15,19H,6-7,12-13H2,1-3H3,(H,29,33)/t15-,19-/m1/s1 IJFKDPNABTXGCF-DNVCBOLYSA-N 320206 3-{[(2R)-4- methylmorpholin- 2-yl]methoxy}-5- (5-methyl-1,3- thiazol-2-yl)- N-{(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl} benzamide::US10174016, Example 373::US10202369, Example 373::US10472354, Example 373 P2X purinoceptor 3 Homo sapiens 21.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320206 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320206&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397505 384223479 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683547 C[C@@H](NC(=O)c1cc(OC[C@@H]2CN(C)CCO2)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F InChI=1S/C24H26F3N5O3S/c1-14-11-28-23(36-14)17-8-16(9-18(10-17)35-13-19-12-32(3)6-7-34-19)22(33)29-15(2)20-4-5-21(31-30-20)24(25,26)27/h4-5,8-11,15,19H,6-7,12-13H2,1-3H3,(H,29,33)/t15-,19+/m1/s1 IJFKDPNABTXGCF-BEFAXECRSA-N 320207 3-{[(2S)-4- methylmorpholin- 2-yl]methoxy}-5- (5-methyl-1,3- thiazol-2-yl)- N-{(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl} benzamide::US10174016, Example 374::US10202369, Example 374::US10472354, Example 374 P2X purinoceptor 3 Homo sapiens 55.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320207 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320207&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397406 384223480 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683549 CCc1cnc(s1)-c1cc(OC[C@@H]2CN(C)CCO2)cc(c1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C25H28F3N5O3S/c1-4-21-12-29-23(37-21)17-7-16(8-19(9-17)36-14-20-13-33(3)5-6-35-20)22(34)32-15(2)18-10-30-24(31-11-18)25(26,27)28/h7-12,15,20H,4-6,13-14H2,1-3H3,(H,32,34)/t15-,20+/m1/s1 PEGAFCGSQABLTK-QRWLVFNGSA-N 320208 3-(5-ethyl-1,3- thiazol-2-yl)-5- {[(2S)-4- methylmorpholin- 2- yl]methoxy}-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 375::US10202369, Example 375::US10472354, Example 375 P2X purinoceptor 3 Homo sapiens 11.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320208 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320208&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397736 384223481 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683551 C[C@@H](NC(=O)c1cc(OC[C@@H]2CN(C)CCO2)cc(c1)-c1ncc(Cl)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H23ClF3N5O3S/c1-13(16-8-29-22(30-9-16)23(25,26)27)31-20(33)14-5-15(21-28-10-19(24)36-21)7-17(6-14)35-12-18-11-32(2)3-4-34-18/h5-10,13,18H,3-4,11-12H2,1-2H3,(H,31,33)/t13-,18+/m1/s1 AJIHXKQJGQMCEX-ACJLOTCBSA-N 320209 3-(5-chloro- 1,3-thiazol-2- yl)-5-{[(2S)-4- methylmorpholin- 2-yl]methoxy}-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 376::US10202369, Example 376::US10472354, Example 376 P2X purinoceptor 3 Homo sapiens 32.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320209 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320209&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397674 384223482 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683553 CCc1cnc(s1)-c1cc(OC[C@H]2CN(C)CCO2)cc(c1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C25H28F3N5O3S/c1-4-21-12-29-23(37-21)17-7-16(8-19(9-17)36-14-20-13-33(3)5-6-35-20)22(34)32-15(2)18-10-30-24(31-11-18)25(26,27)28/h7-12,15,20H,4-6,13-14H2,1-3H3,(H,32,34)/t15-,20-/m1/s1 PEGAFCGSQABLTK-FOIQADDNSA-N 320210 3-(5-ethyl-1,3- thiazol-2-yl)-5- {[(2R)-4- methylmorpholin- 2-yl]methoxy}-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 377::US10202369, Example 377::US10472354, Example 377 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320210 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320210&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397144 384223483 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683555 C[C@@H](NC(=O)c1cc(OC[C@@H]2CCCN2C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H26F3N5O2S/c1-14-10-28-22(35-14)17-7-16(8-20(9-17)34-13-19-5-4-6-32(19)3)21(33)31-15(2)18-11-29-23(30-12-18)24(25,26)27/h7-12,15,19H,4-6,13H2,1-3H3,(H,31,33)/t15-,19+/m1/s1 TYUJHJGDOVFFQY-BEFAXECRSA-N 320211 3-{[(2S)-1- methylpyrrolidin- 2-yl]methoxy}-5- (5-methyl-1,3- thiazol-2-yl)- N-{(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 378::US10202369, Example 378::US10472354, Example 378 P2X purinoceptor 3 Homo sapiens 60.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320211 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320211&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397183 384223484 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683557 C[C@@H](NC(=O)c1cc(OC[C@H]2CCCN2C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H26F3N5O2S/c1-14-10-28-22(35-14)17-7-16(8-20(9-17)34-13-19-5-4-6-32(19)3)21(33)31-15(2)18-11-29-23(30-12-18)24(25,26)27/h7-12,15,19H,4-6,13H2,1-3H3,(H,31,33)/t15-,19-/m1/s1 TYUJHJGDOVFFQY-DNVCBOLYSA-N 320212 3-{[(2R)-1- methylpyrrolidin- 2-yl]methoxy}-5 (5-methyl-1,3- thiazol-2-yl)- N-{(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 379::US10202369, Example 379::US10472354, Example 379 P2X purinoceptor 3 Homo sapiens 42.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320212 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320212&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397315 384223485 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683559 C[C@@H](NC(=O)c1cc(OCC2CCN(C)CC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C25H28F3N5O2S/c1-15-11-29-23(36-15)19-8-18(9-21(10-19)35-14-17-4-6-33(3)7-5-17)22(34)32-16(2)20-12-30-24(31-13-20)25(26,27)28/h8-13,16-17H,4-7,14H2,1-3H3,(H,32,34)/t16-/m1/s1 GQMGTASPVLCRIR-MRXNPFEDSA-N 320213 3-[(1- methylpiperidin- 4-yl)methoxy]-5- (5-methyl-1,3- thiazol-2-yl)- N-{(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 380::US10202369, Example 380::US10472354, Example 380 P2X purinoceptor 3 Homo sapiens 32.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320213 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320213&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397264 384223486 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683561 CC(C)N1CCO[C@@H](COc2cc(cc(c2)-c2ncc(C)s2)C(=O)N[C@H](C)c2cnc(nc2)C(F)(F)F)C1 InChI=1S/C26H30F3N5O3S/c1-15(2)34-5-6-36-22(13-34)14-37-21-8-18(7-19(9-21)24-30-10-16(3)38-24)23(35)33-17(4)20-11-31-25(32-12-20)26(27,28)29/h7-12,15,17,22H,5-6,13-14H2,1-4H3,(H,33,35)/t17-,22-/m1/s1 AOHBYHNFISDLHQ-VGOFRKELSA-N 320214 3-(5-methyl- 1,3-thiazol-2- yl)-5-{[(2R)-4- (propan-2- yl)morpholin- 2-yl]methoxy}- N-{(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 381::US10202369, Example 381::US10472354, Example 381 P2X purinoceptor 3 Homo sapiens 16.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320214 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320214&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397576 384223487 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683563 CC(C)N1CCO[C@H](COc2cc(cc(c2)-c2ncc(C)s2)C(=O)N[C@H](C)c2cnc(nc2)C(F)(F)F)C1 InChI=1S/C26H30F3N5O3S/c1-15(2)34-5-6-36-22(13-34)14-37-21-8-18(7-19(9-21)24-30-10-16(3)38-24)23(35)33-17(4)20-11-31-25(32-12-20)26(27,28)29/h7-12,15,17,22H,5-6,13-14H2,1-4H3,(H,33,35)/t17-,22+/m1/s1 AOHBYHNFISDLHQ-VGSWGCGISA-N 320215 3-(5-methyl- 1,3-thiazol-2- yl)-5-{[(2R)-4- (propan-2- yl)morpholin- 2-yl]methoxy}- N-{(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 382::US10202369, Example 382::US10472354, Example 382 P2X purinoceptor 3 Homo sapiens 13.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320215 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320215&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397421 384223488 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683565 C[C@@H](NC(=O)c1cc(OCC2CN(C)CCC2(F)F)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C25H26F5N5O2S/c1-14-9-31-22(38-14)17-6-16(7-20(8-17)37-13-19-12-35(3)5-4-24(19,26)27)21(36)34-15(2)18-10-32-23(33-11-18)25(28,29)30/h6-11,15,19H,4-5,12-13H2,1-3H3,(H,34,36)/t15-,19?/m1/s1 LGPVNMAGAZJDEW-NYRJJRHWSA-N 320216 3-{[4,4- difluoro-1- methylpiperidin- 3-yl]methoxy}-5- (5-methyl-1,3- thiazol-2-yl)- N-{(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide, as a mixture of 2 diastereoisomers::US10174016, Example 383::US10202369, Example 384::US10472354, Example 383 P2X purinoceptor 3 Homo sapiens 2.00 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320216 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320216&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397497 384223489 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683567 C[C@@H](NC(=O)c1cc(OCC2CN(C)CCC2(F)F)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C25H26F5N5O2S/c1-14-9-31-22(38-14)17-6-16(7-20(8-17)37-13-19-12-35(3)5-4-24(19,26)27)21(36)34-15(2)18-10-32-23(33-11-18)25(28,29)30/h6-11,15,19H,4-5,12-13H2,1-3H3,(H,34,36)/t15-,19?/m1/s1 LGPVNMAGAZJDEW-NYRJJRHWSA-N 320216 3-{[4,4- difluoro-1- methylpiperidin- 3-yl]methoxy}-5- (5-methyl-1,3- thiazol-2-yl)- N-{(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide, as a mixture of 2 diastereoisomers::US10174016, Example 383::US10202369, Example 384::US10472354, Example 383 P2X purinoceptor 3 Homo sapiens 3.00 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320216 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320216&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397497 384223489 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683569 C[C@H](NC(=O)c1cc(OCC2CN(C)CCC2(F)F)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C25H26F5N5O2S/c1-14-9-31-22(38-14)17-6-16(7-20(8-17)37-13-19-12-35(3)5-4-24(19,26)27)21(36)34-15(2)18-10-32-23(33-11-18)25(28,29)30/h6-11,15,19H,4-5,12-13H2,1-3H3,(H,34,36)/t15-,19?/m0/s1 LGPVNMAGAZJDEW-FUKCDUGKSA-N 322574 US10183937, Example 385::US10202369, Example 385 P2X purinoceptor 3 Homo sapiens 3.00 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322574 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322574&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 138375418 384225634 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683571 C[C@@H](NC(=O)c1cc(OCC2(F)CN(C)C2)cc(c1)-c1ncc(C)s1)c1ccc(nc1)C(F)(F)F InChI=1S/C24H24F4N4O2S/c1-14-9-30-22(35-14)18-6-17(7-19(8-18)34-13-23(25)11-32(3)12-23)21(33)31-15(2)16-4-5-20(29-10-16)24(26,27)28/h4-10,15H,11-13H2,1-3H3,(H,31,33)/t15-/m1/s1 YWRAMSXXAJRPGK-OAHLLOKOSA-N 320219 3-[(3-fluoro-1- methylazetidin-3- yl)methoxy]-5-(5- methyl-1,3-thiazol- 2-yl)-N-{(1R)-1-[6- (trifluoromethyl) pyridin-3-yl] ethyl}benzamide::US10174016, Example 386::US10202369, Example 386::US10472354, Example 386 P2X purinoceptor 3 Homo sapiens 24.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320219 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320219&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397321 384223491 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683573 CCc1cnc(s1)-c1cc(OCC2(F)CN(C)C2)cc(c1)C(=O)N[C@H](C)c1ccc(nc1)C(F)(F)F InChI=1S/C25H26F4N4O2S/c1-4-20-11-31-23(36-20)18-7-17(8-19(9-18)35-14-24(26)12-33(3)13-24)22(34)32-15(2)16-5-6-21(30-10-16)25(27,28)29/h5-11,15H,4,12-14H2,1-3H3,(H,32,34)/t15-/m1/s1 HCTVCZSENAWJEB-OAHLLOKOSA-N 320220 3-(5-ethyl-1,3- thiazol-2-yl)-5-[(3- fluoro-1- methylazetidin-3- yl)methoxy]-N- {(1R)-1-[6- (trifluoromethyl) pyridin-3-yl] ethyl}benzamide::US10174016, Example 387::US10202369, Example 387::US10472354, Example 387 P2X purinoceptor 3 Homo sapiens 19.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320220 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320220&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397751 384223492 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683575 C[C@@H](NC(=O)c1cc(OC[C@H]2COCCN2C)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F InChI=1S/C24H26F3N5O3S/c1-14-11-28-23(36-14)17-8-16(9-19(10-17)35-13-18-12-34-7-6-32(18)3)22(33)29-15(2)20-4-5-21(31-30-20)24(25,26)27/h4-5,8-11,15,18H,6-7,12-13H2,1-3H3,(H,29,33)/t15-,18-/m1/s1 SOWWCICJAYGBSY-CRAIPNDOSA-N 320221 3-{[(3R)-4- methylmorpholin-3- yl]methoxy}-5-(5- methyl-1,3-thiazol- 2-yl)-N-{(1R)-1-[6- (trifluoromethyl) pyridazin-3-yl] ethyl}benzamide::US10174016, Example 388::US10202369, Example 388::US10472354, Example 388 P2X purinoceptor 3 Homo sapiens 18.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320221 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320221&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397768 384223493 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683577 C[C@@H](NC(=O)c1cc(OC[C@@H]2COCCN2C)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F InChI=1S/C24H26F3N5O3S/c1-14-11-28-23(36-14)17-8-16(9-19(10-17)35-13-18-12-34-7-6-32(18)3)22(33)29-15(2)20-4-5-21(31-30-20)24(25,26)27/h4-5,8-11,15,18H,6-7,12-13H2,1-3H3,(H,29,33)/t15-,18+/m1/s1 SOWWCICJAYGBSY-QAPCUYQASA-N 320222 3-{[(3S)-4- methylmorpholin-3- yl]methoxy}-5-(5- methyl-1,3-thiazol- 2-yl)-N-{(1R)-1-[6- (trifluoromethyl) pyridazin-3-yl] ethyl}benzamide::US10174016, Example 389::US10202369, Example 389::US10472354, Example 389 P2X purinoceptor 3 Homo sapiens 18.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320222 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320222&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397449 384223494 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683579 CCN1CCO[C@@H](COc2cc(cc(c2)-c2ncc(C)s2)C(=O)N[C@H](C)c2cnc(nc2)C(F)(F)F)C1 InChI=1S/C25H28F3N5O3S/c1-4-33-5-6-35-21(13-33)14-36-20-8-17(7-18(9-20)23-29-10-15(2)37-23)22(34)32-16(3)19-11-30-24(31-12-19)25(26,27)28/h7-12,16,21H,4-6,13-14H2,1-3H3,(H,32,34)/t16-,21-/m1/s1 IJXNJADLTIUKEL-IIBYNOLFSA-N 320223 3-{[(2R)-4-ethylmorpholin-2-yl]methoxy}-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 390::US10202369, Example 390::US10472354, Example 390 P2X purinoceptor 3 Homo sapiens 17.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320223 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320223&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397822 384223495 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683581 C[C@@H](NC(=O)c1cc(OC[C@H]2CN(CC(F)F)CCO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C25H26F5N5O3S/c1-14-8-31-23(39-14)17-5-16(22(36)34-15(2)18-9-32-24(33-10-18)25(28,29)30)6-19(7-17)38-13-20-11-35(3-4-37-20)12-21(26)27/h5-10,15,20-21H,3-4,11-13H2,1-2H3,(H,34,36)/t15-,20-/m1/s1 LANXVVYUHZPONS-FOIQADDNSA-N 320224 3-{[(2R)-4-(2,2-difluoroethyl)morpholin-2-yl]methoxy}-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 391::US10202369, Example 391::US10472354, Example 391 P2X purinoceptor 3 Homo sapiens 19.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320224 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320224&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397746 384223496 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683583 COC(=O)N1CCO[C@@H](COc2cc(cc(c2)-c2ncc(C)s2)C(=O)N[C@H](C)c2cnc(nc2)C(F)(F)F)C1 InChI=1S/C25H26F3N5O5S/c1-14-9-29-22(39-14)17-6-16(21(34)32-15(2)18-10-30-23(31-11-18)25(26,27)28)7-19(8-17)38-13-20-12-33(4-5-37-20)24(35)36-3/h6-11,15,20H,4-5,12-13H2,1-3H3,(H,32,34)/t15-,20-/m1/s1 AMNDVZJYNBRGRX-FOIQADDNSA-N 320225 Methyl (2R)-2-{[3-(5-methyl-1,3-thiazol-2-yl)-5-({(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}carbamoyl)phenoxy]methyl}morpholine-4-carboxylate::US10174016, Example 392::US10202369, Example 392::US10472354, Example 392 P2X purinoceptor 3 Homo sapiens 11.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320225 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320225&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134338451 384223497 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683585 COC(=O)N1CCO[C@H](COc2cc(cc(c2)-c2ncc(C)s2)C(=O)N[C@H](C)c2cnc(nc2)C(F)(F)F)C1 InChI=1S/C25H26F3N5O5S/c1-14-9-29-22(39-14)17-6-16(21(34)32-15(2)18-10-30-23(31-11-18)25(26,27)28)7-19(8-17)38-13-20-12-33(4-5-37-20)24(35)36-3/h6-11,15,20H,4-5,12-13H2,1-3H3,(H,32,34)/t15-,20+/m1/s1 AMNDVZJYNBRGRX-QRWLVFNGSA-N 320226 Methyl (2S)-2- {[3-(5-methyl- 1,3-thiazol-2- yl)-5-({(1R)-1- [2- (trifluoromethyl) pyrimidin-5-yl] ethyl}carbamoyl) phenoxy]methyl} morpholine-4- carboxylate::US10174016, Example 393::US10202369, Example 393::US10472354, Example 393 P2X purinoceptor 3 Homo sapiens 24.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320226 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320226&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134338452 384223498 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 682995 C[C@@H](NC(=O)c1cc(OCC2CCOCC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H25F3N4O3S/c1-14-10-28-22(35-14)18-7-17(8-20(9-18)34-13-16-3-5-33-6-4-16)21(32)31-15(2)19-11-29-23(30-12-19)24(25,26)27/h7-12,15-16H,3-6,13H2,1-2H3,(H,31,32)/t15-/m1/s1 MBJQALPRFLKOPN-OAHLLOKOSA-N 319931 3-(5-Methyl- 1,3-thiazol-2- yl)-5- (tetrahydro- 2H-pyran-4- ylmethoxy)- N-[(1R)-1-[2- (trifluorometh- yl)pyrimidin- 5- yl]ethyl] benzamide::US10174016, Example 98::US10202369, Example 98::US10472354, Example 98 P2X purinoceptor 3 Homo sapiens 1.000 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319931 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319931&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397231 384223211 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 682997 C[C@@H](NC(=O)c1cc(OCC2CCOCC2)cc(c1)-c1ncc(C)s1)c1ccc(C)nn1 InChI=1S/C24H28N4O3S/c1-15-4-5-22(28-27-15)17(3)26-23(29)19-10-20(24-25-13-16(2)32-24)12-21(11-19)31-14-18-6-8-30-9-7-18/h4-5,10-13,17-18H,6-9,14H2,1-3H3,(H,26,29)/t17-/m1/s1 FNFCPAXHCILJLE-QGZVFWFLSA-N 319932 N-[(1R)-1-(6- Methyl- pyridazin-3- yl)ethyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5- (tetrahydro- 2H-pyran-4- ylmethoxy) benzamide::US10174016, Example 99::US10202369, Example 99::US10472354, Example 99 P2X purinoceptor 3 Homo sapiens 2.00 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319932 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319932&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397399 384223212 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 682999 C[C@@H](NC(=O)c1cc(Oc2ccnc(C)c2)cc(c1)-c1ncc(C)s1)c1ccc(C)nn1 InChI=1S/C24H23N5O2S/c1-14-5-6-22(29-28-14)17(4)27-23(30)18-10-19(24-26-13-16(3)32-24)12-21(11-18)31-20-7-8-25-15(2)9-20/h5-13,17H,1-4H3,(H,27,30)/t17-/m1/s1 AOJXRFXYSRJHEO-QGZVFWFLSA-N 319933 N-[(1R)-1-(6- Methyl- pyridazin-3- yl)ethyl]-3- [(2- methylpyridin- 4-yl)oxy]-5- (5-methyl- 1,3-thiazol-2- yl)benzamide::US10174016, Example 100::US10202369, Example 100::US10472354, Example 100 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319933 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319933&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397202 384223213 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683001 Cc1cnc(s1)-c1cc(Oc2ccnc(C)c2)cc(c1)C(=O)NCc1ccc(C)nn1 InChI=1S/C23H21N5O2S/c1-14-4-5-19(28-27-14)13-25-22(29)17-9-18(23-26-12-16(3)31-23)11-21(10-17)30-20-6-7-24-15(2)8-20/h4-12H,13H2,1-3H3,(H,25,29) XCSQCNBYINKWNK-UHFFFAOYSA-N 319934 N-[(6- Methyl- pyridazin-3- yl)methyl]-3- [(2- methylpyridin- 4-yl)oxy]-5- (5-methyl- 1,3-thiazol-2- yl)benzamide::US10174016, Example 101::US10202369, Example 101::US10472354, Example 101 P2X purinoceptor 3 Homo sapiens 15.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319934 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319934&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397744 384223214 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683003 C[C@@H](NC(=O)c1cc(Oc2ccnc(C)c2)cc(c1)-c1ncc(C)s1)c1cnc(C)cn1 InChI=1S/C24H23N5O2S/c1-14-7-20(5-6-25-14)31-21-9-18(8-19(10-21)24-28-12-16(3)32-24)23(30)29-17(4)22-13-26-15(2)11-27-22/h5-13,17H,1-4H3,(H,29,30)/t17-/m1/s1 QEKNBUCJINMCOL-QGZVFWFLSA-N 319935 N-[(1R)-1-(5- Methylpyrazin- 2-yl)ethyl]- 3-[(2- methylpyridin- 4-yl)oxy]-5- (5-methyl- 1,3-thiazol-2- yl)benzamide::US10174016, Example 102::US10202369, Example 102::US10472354, Example 102 P2X purinoceptor 3 Homo sapiens 10.00 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319935 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319935&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397697 384223215 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683005 C[C@@H](NC(=O)c1cc(Oc2ccnc(C)c2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H20F3N5O2S/c1-13-6-19(4-5-28-13)34-20-8-16(7-17(9-20)22-29-10-14(2)35-22)21(33)32-15(3)18-11-30-23(31-12-18)24(25,26)27/h4-12,15H,1-3H3,(H,32,33)/t15-/m1/s1 JXFGKHKXOUTTKZ-OAHLLOKOSA-N 319936 3-[(2- Methylpyridin- 4-yl)oxy]-5- (5-methyl- 1,3-thiazol-2- yl)-N-{(1R)-1- [2- (trifluorometh- yl)pyrimidin- 5- yl]ethyl} benzamide::US10174016, Example 103::US10202369, Example 103::US10472354, Example 103 P2X purinoceptor 3 Homo sapiens 2.00 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319936 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319936&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397214 384223216 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683007 Cc1cnc(s1)-c1cc(Oc2ccnc(C)c2)cc(c1)C(=O)NCc1cnc(C)cn1 InChI=1S/C23H21N5O2S/c1-14-6-20(4-5-24-14)30-21-8-17(7-18(9-21)23-28-11-16(3)31-23)22(29)27-13-19-12-25-15(2)10-26-19/h4-12H,13H2,1-3H3,(H,27,29) FHRXECCRJLFVTP-UHFFFAOYSA-N 319937 N-[(5- Methylpyrazin- 2- yl)methyl]-3- [(2- methylpyridin- 4-yl)oxy]-5- (5-methyl- 1,3-thiazol-2- yl)benzamide::US10174016, Example 104::US10202369, Example 104::US10472354, Example 104 P2X purinoceptor 3 Homo sapiens 51.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319937 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319937&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397645 384223217 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683009 C[C@@H](NC(=O)c1cc(Oc2ccnc(C)c2)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F InChI=1S/C24H20F3N5O2S/c1-13-8-18(6-7-28-13)34-19-10-16(9-17(11-19)23-29-12-14(2)35-23)22(33)30-15(3)20-4-5-21(32-31-20)24(25,26)27/h4-12,15H,1-3H3,(H,30,33)/t15-/m1/s1 DZQXNDYGTRQHHO-OAHLLOKOSA-N 319938 3-[(2- Methylpyridin- 4-yl)oxy]-5- (5-methyl- 1,3-thiazol-2- yl)-N-{(1R)-1- [6- (trifluorometh- yl)pyridazin- 3- yl]ethyl} benzamide::US10174016, Example 105::US10202369, Example 105::US10472354, Example 105 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319938 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319938&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397847 384223218 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683011 C[C@@H](NC(=O)c1cc(Oc2ccnc(C)c2)cc(c1)-c1ncc(C)s1)c1cnc(C)nc1 InChI=1S/C24H23N5O2S/c1-14-7-21(5-6-25-14)31-22-9-18(8-19(10-22)24-28-11-15(2)32-24)23(30)29-16(3)20-12-26-17(4)27-13-20/h5-13,16H,1-4H3,(H,29,30)/t16-/m1/s1 AVOXIOANORGYFZ-MRXNPFEDSA-N 319939 3-[(2-methylpyridin-4-yl)oxy]-N-[(1R)-1-(2-methylpyrimidin-5-yl)ethyl]-5-(5-methyl-1,3-thiazol-2-yl)benzamide::US10174016, Example 106::US10202369, Example 106::US10472354, Example 106 P2X purinoceptor 3 Homo sapiens 16.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319939 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319939&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397227 384223219 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683013 C[C@@H](NC(=O)c1cc(Oc2ccnc(C)c2)cc(c1)-c1ncc(C)s1)c1ccc(C)nc1 InChI=1S/C25H24N4O2S/c1-15-5-6-19(14-27-15)18(4)29-24(30)20-10-21(25-28-13-17(3)32-25)12-23(11-20)31-22-7-8-26-16(2)9-22/h5-14,18H,1-4H3,(H,29,30)/t18-/m1/s1 PNIOXTPFLIQKJT-GOSISDBHSA-N 319940 N-[(1R)-1-(6- Methylpyridin- 3-yl)ethyl]- 3-[(2- methylpyridin- 4-yl)oxy]-5- (5-methyl- 1,3-thiazol-2- yl)benzamide::US10174016, Example 107::US10202369, Example 107::US10472354, Example 107 P2X purinoceptor 3 Homo sapiens 9.00 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319940 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319940&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397329 384223220 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683015 C[C@@H](NC(=O)c1cc(Oc2ccc(C)nc2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H20F3N5O2S/c1-13-4-5-19(12-28-13)34-20-7-16(6-17(8-20)22-29-9-14(2)35-22)21(33)32-15(3)18-10-30-23(31-11-18)24(25,26)27/h4-12,15H,1-3H3,(H,32,33)/t15-/m1/s1 ASXORIIIQIGPLA-OAHLLOKOSA-N 319941 3-[(6-Methylpyridin-3-yl)oxy]-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 108::US10202369, Example 108::US10472354, Example 108 P2X purinoceptor 3 Homo sapiens 11.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319941 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319941&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397249 384223221 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683017 C[C@@H](NC(=O)c1cc(Oc2nnc(C)s2)cc(c1)-c1ncc(C)s1)c1cnc(C)cn1 InChI=1S/C21H20N6O2S2/c1-11-8-23-18(10-22-11)13(3)25-19(28)15-5-16(20-24-9-12(2)30-20)7-17(6-15)29-21-27-26-14(4)31-21/h5-10,13H,1-4H3,(H,25,28)/t13-/m1/s1 SHPJQOXSFBKQMY-CYBMUJFWSA-N 319942 N-[(1R)-1-(5- Methylpyrazin- 2-yl)ethyl]-3- [(5-methyl- 1,3,4- thiadiazol-2- yl)oxy]-5-(5- methyl-1,3- thiazol-2- yl)benzamide::US10174016, Example 109::US10202369, Example 109::US10472354, Example 109 P2X purinoceptor 3 Homo sapiens 235 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319942 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319942&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397425 384223222 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683019 C[C@@H](NC(=O)c1cc(Oc2nnc(C)s2)cc(c1)-c1ncc(C)s1)c1ccc(C)nn1 InChI=1S/C21H20N6O2S2/c1-11-5-6-18(26-24-11)13(3)23-19(28)15-7-16(20-22-10-12(2)30-20)9-17(8-15)29-21-27-25-14(4)31-21/h5-10,13H,1-4H3,(H,23,28)/t13-/m1/s1 YBUIRLYLJALMRA-CYBMUJFWSA-N 319943 N-[(1R)-1-(6- Methylpyridazin- 3-yl)ethyl]- 3-[(5-methyl- 1,3,4- thiadiazol-2- yl)oxy]-5-(5- methyl-1,3- thiazol-2- yl)benzamide::US10174016, Example 110::US10202369, Example 110::US10472354, Example 110 P2X purinoceptor 3 Homo sapiens 114 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319943 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319943&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397265 384223223 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683021 C[C@@H](NC(=O)c1cc(Oc2nnc(C)s2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C21H17F3N6O2S2/c1-10-7-25-18(33-10)14-4-13(5-16(6-14)32-20-30-29-12(3)34-20)17(31)28-11(2)15-8-26-19(27-9-15)21(22,23)24/h4-9,11H,1-3H3,(H,28,31)/t11-/m1/s1 FIVDAXBJTLXBHI-LLVKDONJSA-N 319944 3-[(5-Methyl- 1,3,4- thiadiazol-2- yl)oxy]-5-(5- methyl-1,3- thiazol-2-yl)- N-[(1R)-1-[2- (trifluorometh- yl)pyrimidin-5- yl]ethyl] benzamide::US10174016, Example 111::US10202369, Example 111::US10472354, Example 111 P2X purinoceptor 3 Homo sapiens 16.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319944 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319944&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397223 384223224 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683023 C[C@@H](NC(=O)c1cc(Oc2nncs2)cc(c1)-c1ncc(C)s1)c1cnc(C)cn1 InChI=1S/C20H18N6O2S2/c1-11-7-22-17(9-21-11)13(3)25-18(27)14-4-15(19-23-8-12(2)30-19)6-16(5-14)28-20-26-24-10-29-20/h4-10,13H,1-3H3,(H,25,27)/t13-/m1/s1 DSVXFYAUDDSSDL-CYBMUJFWSA-N 346125 N-[(1R)-1-(5- Methylpyrazin- 2-yl)ethyl]-3- (5-methyl-1,3- thiazol-2-yl)-5- (1,3-thiazol-2- yloxy) benzamide::US10202369, Example 112 P2X purinoceptor 3 Homo sapiens 61.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=346125 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=346125&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134391356 385452176 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683025 C[C@@H](NC(=O)c1cc(Oc2nccs2)cc(c1)-c1ncc(C)s1)c1ccc(C)nn1 InChI=1S/C21H19N5O2S2/c1-12-4-5-18(26-25-12)14(3)24-19(27)15-8-16(20-23-11-13(2)30-20)10-17(9-15)28-21-22-6-7-29-21/h4-11,14H,1-3H3,(H,24,27)/t14-/m1/s1 KTZHJRKMBNLACT-CQSZACIVSA-N 319946 N-[(1R)-1-(6- Methylpyridazin- 3-yl)ethyl]- 3-(5-methyl- 1,3-thiazol-2- yl)-5-(1,3- thiazol-2- yloxy)benzamide::US10174016, Example 113::US10202369, Example 113::US10472354, Example 113 P2X purinoceptor 3 Homo sapiens 43.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319946 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319946&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397679 384223226 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683027 C[C@@H](NC(=O)c1cc(Oc2nccs2)cc(c1)-c1ncc(C)s1)c1ccc(C)nc1 InChI=1S/C22H20N4O2S2/c1-13-4-5-16(12-24-13)15(3)26-20(27)17-8-18(21-25-11-14(2)30-21)10-19(9-17)28-22-23-6-7-29-22/h4-12,15H,1-3H3,(H,26,27)/t15-/m1/s1 WJNIKDPPMLYZOS-OAHLLOKOSA-N 319947 N-[(1R)-1-(6- Methylpyridin- 3-yl)ethyl]-3- (5-methyl-1,3- thiazol-2-yl)-5- (1,3-thiazol-2- yloxy)benzamide::US10174016, Example 114::US10202369, Example 114::US10472354, Example 114 P2X purinoceptor 3 Homo sapiens 38.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319947 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319947&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397612 384223227 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683029 COC(C)(C)COc1cc(cc(c1)-c1ncc(Cl)s1)C(=O)N[C@H](C)c1ccc(Cl)cn1 InChI=1S/C22H23Cl2N3O3S/c1-13(18-6-5-16(23)10-25-18)27-20(28)14-7-15(21-26-11-19(24)31-21)9-17(8-14)30-12-22(2,3)29-4/h5-11,13H,12H2,1-4H3,(H,27,28)/t13-/m1/s1 MHZRDUGBKYAKKB-CYBMUJFWSA-N 319948 N-[(1R)-1-(5-Chloropyridin-2-yl)ethyl]-3-(5-chloro-1,3-thiazol-2-yl)-5-(2-methoxy-2-methylpropoxy)benzamide::US10174016, Example 115::US10202369, Example 115::US10472354, Example 115 P2X purinoceptor 3 Homo sapiens 15.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319948 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319948&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397201 384223228 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683031 COC(C)(C)COc1cc(cc(c1)-c1ncc(Cl)s1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C22H22ClF3N4O3S/c1-12(15-8-28-20(29-9-15)22(24,25)26)30-18(31)13-5-14(19-27-10-17(23)34-19)7-16(6-13)33-11-21(2,3)32-4/h5-10,12H,11H2,1-4H3,(H,30,31)/t12-/m1/s1 QSHVLLWXZBADRN-GFCCVEGCSA-N 319949 3-(5-Chloro-1,3-thiazol-2-yl)-5-(2-methoxy-2-methylpropoxy)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 116::US10202369, Example 116::US10472354, Example 116 P2X purinoceptor 3 Homo sapiens 210 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319949 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319949&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397235 384223229 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683033 COC(C)(C)COc1cc(cc(c1)-c1ncc(Cl)s1)C(=O)N[C@H](C)c1cnc(C)cn1 InChI=1S/C22H25ClN4O3S/c1-13-9-25-18(10-24-13)14(2)27-20(28)15-6-16(21-26-11-19(23)31-21)8-17(7-15)30-12-22(3,4)29-5/h6-11,14H,12H2,1-5H3,(H,27,28)/t14-/m1/s1 IVUVTQZOIPAQFU-CQSZACIVSA-N 319950 3-(5-Chloro-1,3-thiazol-2-yl)-5-(2-methoxy-2-methylpropoxy)-N-[(1R)-1-(5-methylpyrazin-2-yl)ethyl]benzamide::US10174016, Example 117::US10202369, Example 117::US10472354, Example 117 P2X purinoceptor 3 Homo sapiens 36.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319950 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319950&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397711 384223230 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683035 Cc1ccc(CNC(=O)c2cc(OCC3CCOCC3)cc(c2)-c2ncc(s2)C(F)(F)F)nn1 InChI=1S/C23H23F3N4O3S/c1-14-2-3-18(30-29-14)11-27-21(31)16-8-17(22-28-12-20(34-22)23(24,25)26)10-19(9-16)33-13-15-4-6-32-7-5-15/h2-3,8-10,12,15H,4-7,11,13H2,1H3,(H,27,31) JVFRARFSFIRWBD-UHFFFAOYSA-N 319951 N-[(6-Methylpyridazin-3-yl)methyl]-3-(tetrahydro-2H-pyran-4-ylmethoxy)-5-[5-(trifluoromethyl)-1,3-thiazol-2-yl]benzamide::US10174016, Example 118::US10202369, Example 118::US10472354, Example 118 P2X purinoceptor 3 Homo sapiens 198 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319951 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319951&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397366 384223231 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683037 Cc1ccc(CNC(=O)c2cc(OCC3CCOCC3)cc(c2)-c2ncc(s2)C2CCC2)nn1 InChI=1S/C26H30N4O3S/c1-17-5-6-22(30-29-17)14-27-25(31)20-11-21(26-28-15-24(34-26)19-3-2-4-19)13-23(12-20)33-16-18-7-9-32-10-8-18/h5-6,11-13,15,18-19H,2-4,7-10,14,16H2,1H3,(H,27,31) UIEYRDUAWDAEID-UHFFFAOYSA-N 319952 3-(5-Cyclobutyl-1,3-thiazol-2-yl)-N-[(6-methylpyridazin-3-yl)methyl]-5-(tetrahydro-2H-pyran-4-ylmethoxy)benzamide::US10174016, Example 119::US10202369, Example 119::US10472354, Example 119 P2X purinoceptor 3 Homo sapiens 24.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319952 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319952&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397447 384223232 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683039 C[C@@H](NC(=O)c1cc(OCC2CCOCC2)cc(c1)-c1ncc(s1)C1CCC1)c1cnc(nc1)C(F)(F)F InChI=1S/C27H29F3N4O3S/c1-16(21-12-32-26(33-13-21)27(28,29)30)34-24(35)19-9-20(25-31-14-23(38-25)18-3-2-4-18)11-22(10-19)37-15-17-5-7-36-8-6-17/h9-14,16-18H,2-8,15H2,1H3,(H,34,35)/t16-/m1/s1 XFOWUTGLWQUPCN-MRXNPFEDSA-N 319953 3-(5-Cyclobutyl-1,3-thiazol-2-yl)-5-(tetrahydro-2H-pyran-4-ylmethoxy)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 120::US10202369, Example 120::US10472354, Example 120 P2X purinoceptor 3 Homo sapiens 14.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319953 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319953&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397437 384223233 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683041 C[C@@H](NC(=O)c1cc(OC[C@H]2CCOC2)cc(c1)-c1ncc(s1)C1CCC1)c1cnc(C)cn1 InChI=1S/C26H30N4O3S/c1-16-11-28-23(12-27-16)17(2)30-25(31)20-8-21(26-29-13-24(34-26)19-4-3-5-19)10-22(9-20)33-15-18-6-7-32-14-18/h8-13,17-19H,3-7,14-15H2,1-2H3,(H,30,31)/t17-,18+/m1/s1 ZBRXLMDGZXDHGV-MSOLQXFVSA-N 319954 3-(5-Cyclobutyl-1,3-thiazol-2-yl)-N-[(1R)-1-(5-methylpyrazin-2-yl)ethyl]-5-[(3S)-tetrahydrofuran-3-ylmethoxy]benzamide::US10174016, Example 121::US10202369, Example 121::US10472354, Example 271 P2X purinoceptor 3 Homo sapiens 79.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319954 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319954&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397486 384223234 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683043 Cc1ccc(CNC(=O)c2cc(OC[C@H]3CCOC3)cc(c2)-c2ncc(s2)C2CCC2)nn1 InChI=1S/C25H28N4O3S/c1-16-5-6-21(29-28-16)12-26-24(30)19-9-20(25-27-13-23(33-25)18-3-2-4-18)11-22(10-19)32-15-17-7-8-31-14-17/h5-6,9-11,13,17-18H,2-4,7-8,12,14-15H2,1H3,(H,26,30)/t17-/m0/s1 DCRIJNFHBDAZLX-KRWDZBQOSA-N 319955 3-(5-Cyclobutyl-1,3-thiazol-2-yl)-N-[(6-methylpyridazin-3-yl)methyl]-5-[(3S)-tetrahydrofuran-3-ylmethoxy]benzamide::US10174016, Example 122::US10202369, Example 122::US10472354, Example 122 P2X purinoceptor 3 Homo sapiens 106 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319955 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319955&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397270 384223235 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683045 C[C@@H](NC(=O)c1cc(OC[C@H]2CCOC2)cc(c1)-c1ncc(s1)C1CCC1)c1cnc(nc1)C(F)(F)F InChI=1S/C26H27F3N4O3S/c1-15(20-10-31-25(32-11-20)26(27,28)29)33-23(34)18-7-19(24-30-12-22(37-24)17-3-2-4-17)9-21(8-18)36-14-16-5-6-35-13-16/h7-12,15-17H,2-6,13-14H2,1H3,(H,33,34)/t15-,16+/m1/s1 JWRPHAGJMIAQMD-CVEARBPZSA-N 319956 3-(5-Cyclobutyl-1,3-thiazol-2-yl)-5-[(3S)-tetrahydrofuran-3-ylmethoxy]-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 123::US10202369, Example 123::US10472354, Example 272 P2X purinoceptor 3 Homo sapiens 46.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319956 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319956&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397161 384223236 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683047 C[C@@H](NC(=O)c1cc(OCC2CCOCC2)cc(c1)-c1ncc(s1)C1CCC1)c1cnc(C)nc1 InChI=1S/C27H32N4O3S/c1-17(23-13-28-18(2)29-14-23)31-26(32)21-10-22(27-30-15-25(35-27)20-4-3-5-20)12-24(11-21)34-16-19-6-8-33-9-7-19/h10-15,17,19-20H,3-9,16H2,1-2H3,(H,31,32)/t17-/m1/s1 WEHPOEFAIDTUPC-QGZVFWFLSA-N 319957 3-(5-Cyclobutyl-1,3-thiazol-2-yl)-N-[(1R)-1-(2-methylpyrimidin-5-yl)ethyl]-5-(tetrahydro-2H-pyran-4-ylmethoxy)benzamide::US10174016, Example 124::US10202369, Example 124::US10472354, Example 124 P2X purinoceptor 3 Homo sapiens 27.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319957 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319957&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397614 384223237 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683049 CCc1cnc(s1)-c1cc(OCC2CCOCC2)cc(c1)C(=O)N[C@H](C)c1cnc(C)nc1 InChI=1S/C25H30N4O3S/c1-4-23-14-28-25(33-23)20-9-19(10-22(11-20)32-15-18-5-7-31-8-6-18)24(30)29-16(2)21-12-26-17(3)27-13-21/h9-14,16,18H,4-8,15H2,1-3H3,(H,29,30)/t16-/m1/s1 DTZIYRRTWOGOEN-MRXNPFEDSA-N 319958 3-(5-Ethyl-1,3-thiazol-2-yl)-N-[(1R)-1-(2-methylpyrimidin-5-yl)ethyl]-5-(tetrahydro-2H-pyran-4-ylmethoxy)benzamide::US10174016, Example 125::US10202369, Example 125::US10472354, Example 125 P2X purinoceptor 3 Homo sapiens 3.00 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319958 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319958&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397256 384223238 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683051 CC(C)c1cnc(s1)-c1cc(OCC2CCOCC2)cc(c1)C(=O)N[C@H](C)c1cnc(C)nc1 InChI=1S/C26H32N4O3S/c1-16(2)24-14-29-26(34-24)21-9-20(10-23(11-21)33-15-19-5-7-32-8-6-19)25(31)30-17(3)22-12-27-18(4)28-13-22/h9-14,16-17,19H,5-8,15H2,1-4H3,(H,30,31)/t17-/m1/s1 OFIYJECBOJUELW-QGZVFWFLSA-N 319959 N-[(1R)-1-(2-Methylpyrimidin-5-yl)ethyl]-3-[5-(propan-2-yl)-1,3-thiazol-2-yl]-5-(tetrahydro-2H-pyran-4-ylmethoxy)benzamide::US10174016, Example 126::US10202369, Example 126::US10472354, Example 126 P2X purinoceptor 3 Homo sapiens 34.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319959 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319959&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397136 384223239 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683053 C[C@@H](NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(s1)C1CCC1)c1ccc(C)nn1 InChI=1S/C26H30N4O3S/c1-16-6-7-23(30-29-16)17(2)28-25(31)19-12-20(26-27-15-24(34-26)18-4-3-5-18)14-22(13-19)33-21-8-10-32-11-9-21/h6-7,12-15,17-18,21H,3-5,8-11H2,1-2H3,(H,28,31)/t17-/m1/s1 WWWCBSCSEOPHLV-QGZVFWFLSA-N 319960 3-(5-Cyclobutyl-1,3-thiazol-2-yl)-N-[(1R)-1-(6-methylpyridazin-3-yl)ethyl]-5-(tetrahydro-2H-pyran-4-yloxy)benzamide::US10174016, Example 127::US10202369, Example 127::US10472354, Example 127 P2X purinoceptor 3 Homo sapiens 111 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319960 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319960&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397331 384223240 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683055 CCc1cnc(s1)-c1cc(OC2CCOCC2)cc(c1)C(=O)N[C@H](C)c1ccc(C)nn1 InChI=1S/C24H28N4O3S/c1-4-21-14-25-24(32-21)18-11-17(12-20(13-18)31-19-7-9-30-10-8-19)23(29)26-16(3)22-6-5-15(2)27-28-22/h5-6,11-14,16,19H,4,7-10H2,1-3H3,(H,26,29)/t16-/m1/s1 ZSPSPZOSCRXZOC-MRXNPFEDSA-N 319961 3-(5-Ethyl-1,3-thiazol-2-yl)-N-[(1R)-1-(6-methylpyridazin-3-yl)ethyl]-5-(tetrahydro-2H-pyran-4-yloxy)benzamide::US10174016, Example 128::US10202369, Example 128::US10472354, Example 128 P2X purinoceptor 3 Homo sapiens 10.00 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319961 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319961&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397510 384223241 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683057 CCc1cnc(s1)-c1cc(OC2CCOCC2)cc(c1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C24H25F3N4O3S/c1-3-20-13-28-22(35-20)16-8-15(9-19(10-16)34-18-4-6-33-7-5-18)21(32)31-14(2)17-11-29-23(30-12-17)24(25,26)27/h8-14,18H,3-7H2,1-2H3,(H,31,32)/t14-/m1/s1 HAECKPIYFMDTPM-CQSZACIVSA-N 319962 3-(5-Ethyl-1,3-thiazol-2-yl)-5-(tetrahydro-2H-pyran-4-yloxy)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 129::US10202369, Example 129::US10472354, Example 129 P2X purinoceptor 3 Homo sapiens 3.00 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319962 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319962&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397362 384223242 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683059 C[C@@H](NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1cnc(C)nc1 InChI=1S/C22H24N4O3S/c1-13-9-25-22(30-13)17-6-16(7-20(8-17)29-19-4-5-28-12-19)21(27)26-14(2)18-10-23-15(3)24-11-18/h6-11,14,19H,4-5,12H2,1-3H3,(H,26,27)/t14-,19+/m1/s1 RHVHBKMOULQMJQ-KUHUBIRLSA-N 319963 N-[(1R)-1-(2-Methylpyrimidin-5-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(3S)-tetrahydrofuran-3-yloxy]benzamide::US10174016, Example 130::US10202369, Example 130::US10472354, Example 130 P2X purinoceptor 3 Homo sapiens 74.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319963 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319963&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397599 384223243 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683587 C[C@@H](NC(=O)c1cc(OCC2CNC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C22H22F3N5O2S/c1-12-6-27-20(33-12)16-3-15(4-18(5-16)32-11-14-7-26-8-14)19(31)30-13(2)17-9-28-21(29-10-17)22(23,24)25/h3-6,9-10,13-14,26H,7-8,11H2,1-2H3,(H,30,31)/t13-/m1/s1 MHYFOJHMKOGSKR-CYBMUJFWSA-N 320227 3-(Azetidin-3-ylmethoxy)-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 394::US10202369, Example 394::US10472354, Example 394 P2X purinoceptor 3 Homo sapiens 82.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320227 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320227&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397376 384223499 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683589 C[C@@H](NC(=O)c1cc(OC[C@H]2COCC(=O)N2C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H24F3N5O4S/c1-13-7-28-22(37-13)16-4-15(5-19(6-16)36-11-18-10-35-12-20(33)32(18)3)21(34)31-14(2)17-8-29-23(30-9-17)24(25,26)27/h4-9,14,18H,10-12H2,1-3H3,(H,31,34)/t14-,18-/m1/s1 SDFLFPYVVNTAIN-RDTXWAMCSA-N 320228 3-{[(3R)-4-methyl-5-oxomorpholin-3-yl]methoxyl}-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 395::US10202369, Example 395::US10472354, Example 395 P2X purinoceptor 3 Homo sapiens 30.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320228 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320228&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397767 384223500 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683591 C[C@@H](NC(=O)c1cc(OC[C@H]2COCC(=O)N2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H22F3N5O4S/c1-12-6-27-21(36-12)15-3-14(4-18(5-15)35-10-17-9-34-11-19(32)31-17)20(33)30-13(2)16-7-28-22(29-8-16)23(24,25)26/h3-8,13,17H,9-11H2,1-2H3,(H,30,33)(H,31,32)/t13-,17-/m1/s1 QBCIMXIDQXCQLC-CXAGYDPISA-N 320229 3-(5-methyl-1,3- thiazol-2-yl)-5- {[(3R)-5- oxomorpholin-3- yl]methoxy}-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5-yl] ethyl}benzamide::US10174016, Example 396::US10202369, Example 396::US10472354, Example 396 P2X purinoceptor 3 Homo sapiens 22.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320229 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320229&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397733 384223501 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683593 C[C@@H](NC(=O)c1cc(OC[C@@H]2CN(C)C(=O)O2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H22F3N5O4S/c1-12-7-27-20(36-12)15-4-14(5-17(6-15)34-11-18-10-31(3)22(33)35-18)19(32)30-13(2)16-8-28-21(29-9-16)23(24,25)26/h4-9,13,18H,10-11H2,1-3H3,(H,30,32)/t13-,18+/m1/s1 OAEQMLBAMDEFGR-ACJLOTCBSA-N 320230 3-{[(5S)-3-methyl-2- oxo-1,3-oxazolidin- 5-yl]methoxy}-5-(5- methyl-1,3-thiazol- 2-yl)-N-{(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 397::US10202369, Example 397::US10472354, Example 397 P2X purinoceptor 3 Homo sapiens 15.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320230 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320230&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397304 384223502 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683595 C[C@@H](NC(=O)c1cc(OC[C@H]2CN(C)C(=O)O2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H22F3N5O4S/c1-12-7-27-20(36-12)15-4-14(5-17(6-15)34-11-18-10-31(3)22(33)35-18)19(32)30-13(2)16-8-28-21(29-9-16)23(24,25)26/h4-9,13,18H,10-11H2,1-3H3,(H,30,32)/t13-,18-/m1/s1 OAEQMLBAMDEFGR-FZKQIMNGSA-N 320231 3-{[(5R)-3-methyl-2- oxo-1,3-oxazolidin- 5-yl]methoxy}-5-(5- methyl-1,3-thiazol- 2-yl)-N-{(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 398::US10202369, Example 398::US10472354, Example 398 P2X purinoceptor 3 Homo sapiens 17.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320231 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320231&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397297 384223503 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683597 C[C@@H](NC(=O)c1cc(OC[C@H]2CN(C)C(=O)CO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H24F3N5O4S/c1-13-7-28-22(37-13)16-4-15(5-18(6-16)35-11-19-10-32(3)20(33)12-36-19)21(34)31-14(2)17-8-29-23(30-9-17)24(25,26)27/h4-9,14,19H,10-12H2,1-3H3,(H,31,34)/t14-,19-/m1/s1 UCMZCPXWJACEJN-AUUYWEPGSA-N 320232 3-{[(2R)-4-methyl-5- oxomorpholin-2-yl] methoxy}-5-(5- methyl-1,3-thiazol- 2-yl)-N-{(1R)-1-[2- (trifluoromethyl) pyrimidin-5-yl] ethyl}benzamide::US10174016, Example 399::US10202369, Example 399::US10472354, Example 399 P2X purinoceptor 3 Homo sapiens 69.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320232 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320232&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397565 384223504 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683599 C[C@@H](NC(=O)c1cc(OC[C@@H]2CNC(=O)CO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H22F3N5O4S/c1-12-6-28-21(36-12)15-3-14(4-17(5-15)34-10-18-9-27-19(32)11-35-18)20(33)31-13(2)16-7-29-22(30-8-16)23(24,25)26/h3-8,13,18H,9-11H2,1-2H3,(H,27,32)(H,31,33)/t13-,18+/m1/s1 SQKDWNUUISQXQF-ACJLOTCBSA-N 320233 3-(5-methyl-1,3- thiazol-2-yl)-5- {[(2S)-5- oxomorpholin-2- yl]methoxy}-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 400::US10202369, Example 400::US10472354, Example 400 P2X purinoceptor 3 Homo sapiens 59.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320233 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320233&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397173 384223505 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683601 C[C@@H](NC(=O)c1cc(OC[C@@H]2CN(C)C(=O)CO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H24F3N5O4S/c1-13-7-28-22(37-13)16-4-15(5-18(6-16)35-11-19-10-32(3)20(33)12-36-19)21(34)31-14(2)17-8-29-23(30-9-17)24(25,26)27/h4-9,14,19H,10-12H2,1-3H3,(H,31,34)/t14-,19+/m1/s1 UCMZCPXWJACEJN-KUHUBIRLSA-N 320234 3-{[(2S)-4-methyl-5- oxomorpholin-2-yl] methoxy}-5-(5- methyl-1,3-thiazol- 2-yl)-N-{(1R)-1-[2- (trifluoromethyl) pyrimidin-5-yl] ethyl}benzamide::US10174016, Example 401::US10202369, Example 401::US10472354, Example 401 P2X purinoceptor 3 Homo sapiens 30.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320234 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320234&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397710 384223506 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683603 C[C@@H](NC(=O)c1cc(OC[C@@H]2COC(=O)CN2C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H24F3N5O4S/c1-13-7-28-22(37-13)16-4-15(5-19(6-16)35-11-18-12-36-20(33)10-32(18)3)21(34)31-14(2)17-8-29-23(30-9-17)24(25,26)27/h4-9,14,18H,10-12H2,1-3H3,(H,31,34)/t14-,18-/m1/s1 JINXRBWBLDWPDI-RDTXWAMCSA-N 346415 3-{[(3S)-4-methyl-5- oxomorpholin-3- yl]methoxy}-5-(5- methyl-1,3-thiazol-2- yl)-N-{(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10202369, Example 402 P2X purinoceptor 3 Homo sapiens 21.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=346415 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=346415&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134391360 385452461 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683605 C[C@@H](NC(=O)c1cc(OC[C@@H]2COC(=O)CN2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H22F3N5O4S/c1-12-6-28-21(36-12)15-3-14(4-18(5-15)34-10-17-11-35-19(32)9-27-17)20(33)31-13(2)16-7-29-22(30-8-16)23(24,25)26/h3-8,13,17,27H,9-11H2,1-2H3,(H,31,33)/t13-,17-/m1/s1 DQPJGRQHAAMQCH-CXAGYDPISA-N 346416 3-(5-methyl-1,3- thiazol-2-yl)-5- {[(3S)-5- oxomorpholin-3- yl]methoxy}-N-{(1R)- 1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10202369, Example 403 P2X purinoceptor 3 Homo sapiens 56.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=346416 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=346416&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134391361 385452462 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683607 C[C@@H](NC(=O)c1cc(OCC23CC(CO2)N(C3)C(=O)OC(C)(C)C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C29H32F3N5O5S/c1-16-10-33-24(43-16)19-6-18(23(38)36-17(2)20-11-34-25(35-12-20)29(30,31)32)7-22(8-19)40-15-28-9-21(13-41-28)37(14-28)26(39)42-27(3,4)5/h6-8,10-12,17,21H,9,13-15H2,1-5H3,(H,36,38)/t17-,21?,28?/m1/s1 FPSSQFUABOQNNZ-RWNQLPSJSA-N 320237 US10174016, Example 404::US10202369, Example 404::US10472354, Example 404::tert-butyl 1-{[3-(5- methyl-1,3-thiazol- 2-yl)-5-({(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}carbamoyl) phenoxy]methyl}-2- oxa-5- azabicyclo[2.2.1] heptane-5- carboxylate, as a mixture of 2 diastereoisomers P2X purinoceptor 3 Homo sapiens 44.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320237 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320237&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397508 384223509 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683609 CC(C)N1CC2(COc3cc(cc(c3)-c3ncc(C)s3)C(=O)N[C@H](C)c3cnc(nc3)C(F)(F)F)CC1CO2 InChI=1S/C27H30F3N5O3S/c1-15(2)35-13-26(8-21(35)12-38-26)14-37-22-6-18(5-19(7-22)24-31-9-16(3)39-24)23(36)34-17(4)20-10-32-25(33-11-20)27(28,29)30/h5-7,9-11,15,17,21H,8,12-14H2,1-4H3,(H,34,36)/t17-,21?,26?/m1/s1 YPUYZHJKGABFEF-XJNIYMOYSA-N 320238 3-[(5-isopropyl-2- oxa-5-azabicyclo [2.2.1]hept-1-yl) methoxy]-5- (5-methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide, as a mixture of 2 diastereoisomers::US10174016, Example 405::US10202369, Example 405::US10472354, Example 405 P2X purinoceptor 3 Homo sapiens 17.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320238 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320238&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397496 384223510 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683611 C[C@@H](NC(=O)c1cc(OCC23CC(CO2)N(C)C3)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C25H26F3N5O3S/c1-14-8-29-22(37-14)17-4-16(5-20(6-17)35-13-24-7-19(11-36-24)33(3)12-24)21(34)32-15(2)18-9-30-23(31-10-18)25(26,27)28/h4-6,8-10,15,19H,7,11-13H2,1-3H3,(H,32,34)/t15-,19?,24?/m1/s1 QZIIXNSQPLEQAW-QOFOLWBBSA-N 320239 3-[(5-methyl-2- oxa-5-azabicyclo [2.2.1]hept-1-yl) methoxy]-5- (5-methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide, as a mixture of 2 diastereoisomers::US10174016, Example 406::US10202369, Example 406::US10472354, Example 406 P2X purinoceptor 3 Homo sapiens 26.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320239 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320239&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397318 384223511 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683613 C[C@@H](NC(=O)c1cc(OCC23CNC(CO2)C3)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H24F3N5O3S/c1-13-7-28-21(36-13)16-3-15(4-19(5-16)34-12-23-6-18(10-35-23)31-11-23)20(33)32-14(2)17-8-29-22(30-9-17)24(25,26)27/h3-5,7-9,14,18,31H,6,10-12H2,1-2H3,(H,32,33)/t14-,18?,23?/m1/s1 NAZJZFLNXXGFCR-IHDUPTFDSA-N 320240 3-(5-Methyl-1,3-thiazol-2-yl)-5-[2-oxa-5-azabicyclo[2.2.1]hept-1-ylmethoxy]-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide, as a Mixture of 2 Diastereoisomers::US10174016, Example 407::US10202369, Example 407::US10472354, Example 407 P2X purinoceptor 3 Homo sapiens 15.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320240 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320240&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397648 384223512 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683615 CCCN1CC2(COc3cc(cc(c3)-c3ncc(C)s3)C(=O)N[C@H](C)c3cnc(nc3)C(F)(F)F)CC1CO2 InChI=1S/C27H30F3N5O3S/c1-4-5-35-14-26(9-21(35)13-38-26)15-37-22-7-18(6-19(8-22)24-31-10-16(2)39-24)23(36)34-17(3)20-11-32-25(33-12-20)27(28,29)30/h6-8,10-12,17,21H,4-5,9,13-15H2,1-3H3,(H,34,36)/t17-,21?,26?/m1/s1 AAPJJGZIWGLKBD-XJNIYMOYSA-N 320241 3-(5-methyl-1,3- thiazol-2-yl)-5-[(5- propyl-2- oxa-5-azabicyclo [2.2.1]hept-1-yl) methoxy]-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide, as a mixture of 2 diastereoisomers::US10174016, Example 408::US10202369, Example 408::US10472354, Example 408 P2X purinoceptor 3 Homo sapiens 32.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320241 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320241&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397789 384223513 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683617 COC(=O)N1CC2(COc3cc(cc(c3)-c3ncc(C)s3)C(=O)N[C@H](C)c3cnc(nc3)C(F)(F)F)CC1CO2 InChI=1S/C26H26F3N5O5S/c1-14-8-30-22(40-14)17-4-16(21(35)33-15(2)18-9-31-23(32-10-18)26(27,28)29)5-20(6-17)38-13-25-7-19(11-39-25)34(12-25)24(36)37-3/h4-6,8-10,15,19H,7,11-13H2,1-3H3,(H,33,35)/t15-,19?,25?/m1/s1 ACUSXDHHFJWBEG-QYRGRQSGSA-N 320242 Methyl 1-{[3-(5-methyl-1,3-thiazol-2-yl)-5-({(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}carbamoyl)phenoxy]methyl}-2-oxa-5-azabicyclo[2.2.1]heptane-5-carboxylate, as a mixture of 2 diastereoisomers::US10174016, Example 409::US10202369, Example 409::US10472354, Example 409 P2X purinoceptor 3 Homo sapiens 22.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320242 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320242&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397200 384223514 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683619 CCOC(=O)N1CC2(COc3cc(cc(c3)-c3ncc(C)s3)C(=O)N[C@H](C)c3cnc(nc3)C(F)(F)F)CC1CO2 InChI=1S/C27H28F3N5O5S/c1-4-38-25(37)35-13-26(8-20(35)12-40-26)14-39-21-6-17(5-18(7-21)23-31-9-15(2)41-23)22(36)34-16(3)19-10-32-24(33-11-19)27(28,29)30/h5-7,9-11,16,20H,4,8,12-14H2,1-3H3,(H,34,36)/t16-,20?,26?/m1/s1 MVNNYWBQRAUUBD-ORALUJHKSA-N 320243 Ethyl 1-{[3-(5-methyl-1,3-thiazol-2-yl)-5-({(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}carbamoyl)phenoxy]methyl}-2-oxa-5-azabicyclo[2.2.1]heptane-5-carboxylate, as a Mixture of 2 Diastereoisomers::US10174016, Example 410::US10202369, Example 410::US10472354, Example 410 P2X purinoceptor 3 Homo sapiens 22.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320243 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320243&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397180 384223515 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683621 CCN1CCO[C@H](COc2cc(cc(c2)-c2ncc(C)s2)C(=O)N[C@H](C)c2cnc(nc2)C(F)(F)F)C1 InChI=1S/C25H28F3N5O3S/c1-4-33-5-6-35-21(13-33)14-36-20-8-17(7-18(9-20)23-29-10-15(2)37-23)22(34)32-16(3)19-11-30-24(31-12-19)25(26,27)28/h7-12,16,21H,4-6,13-14H2,1-3H3,(H,32,34)/t16-,21+/m1/s1 IJXNJADLTIUKEL-IERDGZPVSA-N 320244 3-{[(2S)-4-ethylmorpholin-2-yl]methoxy}-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 411::US10202369, Example 411::US10472354, Example 411 P2X purinoceptor 3 Homo sapiens 20.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320244 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320244&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397533 384223516 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683623 C[C@H](NC(=O)c1cc(OC[C@H]2CN(CCO2)C(=O)OC(C)(C)C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C28H32F3N5O5S/c1-16-11-32-24(42-16)19-8-18(23(37)35-17(2)20-12-33-25(34-13-20)28(29,30)31)9-21(10-19)40-15-22-14-36(6-7-39-22)26(38)41-27(3,4)5/h8-13,17,22H,6-7,14-15H2,1-5H3,(H,35,37)/t17-,22+/m0/s1 OEKUZTDVCYAZBS-HTAPYJJXSA-N 320245 Tert-butyl (2R)-2- {[3-(5-methyl-1,3- thiazol-2-yl)-5- ({(1S)-1-[2- (trifluoromethyl) pyrimidin-5-yl] ethyl]carbamoyl) phenoxy]methyl} morpholine-4- carboxylate::US10174016, Example 412::US10202369, Example 412 P2X purinoceptor 3 Homo sapiens 687 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320245 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320245&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134338453 384223517 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683625 C[C@H](NC(=O)c1cc(OC[C@H]2CNCCO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H24F3N5O3S/c1-13-8-28-21(35-13)16-5-15(6-18(7-16)34-12-19-11-27-3-4-33-19)20(32)31-14(2)17-9-29-22(30-10-17)23(24,25)26/h5-10,14,19,27H,3-4,11-12H2,1-2H3,(H,31,32)/t14-,19+/m0/s1 HRVUBTPQOQIHTK-IFXJQAMLSA-N 320246 3-(5-methyl- 1,3-thiazol-2- yl)-5-[(2R)- morpholin-2- ylmethoxy]-N- {(1S)-1-[2- (trifluoromethyl) pyrimidin-5-yl] ethyl}benzamide::US10174016, Example 413::US10202369, Example 413::US10472354, Example 413 P2X purinoceptor 3 Homo sapiens 597 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320246 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320246&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397518 384223518 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683627 CCc1cnc(s1)-c1cc(OC[C@@H]2CNCCO2)cc(c1)C(=O)N[C@H](C)c1ccc(nn1)C(F)(F)F InChI=1S/C24H26F3N5O3S/c1-3-19-12-29-23(36-19)16-8-15(9-17(10-16)35-13-18-11-28-6-7-34-18)22(33)30-14(2)20-4-5-21(32-31-20)24(25,26)27/h4-5,8-10,12,14,18,28H,3,6-7,11,13H2,1-2H3,(H,30,33)/t14-,18+/m1/s1 PAVCMPZQEBSSQV-KDOFPFPSSA-N 320247 3-(5-ethyl-1,3- thiazol-2-yl)-5- [(2S)- morpholin-2- ylmethoxy]-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3-yl] ethyl}benzamide::US10174016, Example 414::US10202369, Example 414::US10472354, Example 414 P2X purinoceptor 3 Homo sapiens 29.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320247 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320247&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397150 384223519 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683629 CCc1cnc(s1)-c1cc(OC[C@H]2CNCCO2)cc(c1)C(=O)N[C@H](C)c1ccc(nn1)C(F)(F)F InChI=1S/C24H26F3N5O3S/c1-3-19-12-29-23(36-19)16-8-15(9-17(10-16)35-13-18-11-28-6-7-34-18)22(33)30-14(2)20-4-5-21(32-31-20)24(25,26)27/h4-5,8-10,12,14,18,28H,3,6-7,11,13H2,1-2H3,(H,30,33)/t14-,18-/m1/s1 PAVCMPZQEBSSQV-RDTXWAMCSA-N 320248 3-(5-ethyl-1,3- thiazol-2-yl)-5- [(2R)- morpholin-2- ylmethoxy]-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3-yl] ethyl}benzamide::US10174016, Example 415::US10202369, Example 415::US10472354, Example 415 P2X purinoceptor 3 Homo sapiens 10.00 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320248 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320248&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397550 384223520 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683631 C[C@H](NC(=O)c1cc(OC[C@H]2CN(C)CCO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H26F3N5O3S/c1-14-9-28-22(36-14)17-6-16(7-19(8-17)35-13-20-12-32(3)4-5-34-20)21(33)31-15(2)18-10-29-23(30-11-18)24(25,26)27/h6-11,15,20H,4-5,12-13H2,1-3H3,(H,31,33)/t15-,20+/m0/s1 MROBUJILSMBILX-MGPUTAFESA-N 320249 3-{[(2R)-4- methylmorpholin- 2-yl]methoxy}- 5-(5-methyl-1,3- thiazol-2-yl)- N-{(1S)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 416::US10202369, Example 416 P2X purinoceptor 3 Homo sapiens 227 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320249 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320249&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397764 384223521 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683633 C[C@H](NC(=O)c1cc(OC[C@@H]2CN(C)CCO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H26F3N5O3S/c1-14-9-28-22(36-14)17-6-16(7-19(8-17)35-13-20-12-32(3)4-5-34-20)21(33)31-15(2)18-10-29-23(30-11-18)24(25,26)27/h6-11,15,20H,4-5,12-13H2,1-3H3,(H,31,33)/t15-,20-/m0/s1 MROBUJILSMBILX-YWZLYKJASA-N 320250 3-{[(2S)-4- methylmorpholin- 2-yl]methoxy}- 5-(5-methyl-1,3- thiazol-2-yl)- N-{(1S)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 417::US10202369, Example 417 P2X purinoceptor 3 Homo sapiens 434 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320250 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320250&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397582 384223522 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683635 CCc1cnc(s1)-c1cc(OC[C@@H]2CN(C)CCO2)cc(c1)C(=O)N[C@H](C)c1ccc(nn1)C(F)(F)F InChI=1S/C25H28F3N5O3S/c1-4-20-12-29-24(37-20)17-9-16(10-18(11-17)36-14-19-13-33(3)7-8-35-19)23(34)30-15(2)21-5-6-22(32-31-21)25(26,27)28/h5-6,9-12,15,19H,4,7-8,13-14H2,1-3H3,(H,30,34)/t15-,19+/m1/s1 SIFMRPZFMXLARV-BEFAXECRSA-N 322607 3-(5-Ethyl-1,3- thiazol-2-yl)-5- {[(2S)-4- methyl- morpholin-2- yl]methoxy}-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl} benzamide::US10183937, Example 418::US10202369, Example 418::US10472354, Example 418 P2X purinoceptor 3 Homo sapiens 23.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322607 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322607&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397330 384225667 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683637 CCc1cnc(s1)-c1cc(OC[C@H]2CN(C)CCO2)cc(c1)C(=O)N[C@H](C)c1ccc(nn1)C(F)(F)F InChI=1S/C25H28F3N5O3S/c1-4-20-12-29-24(37-20)17-9-16(10-18(11-17)36-14-19-13-33(3)7-8-35-19)23(34)30-15(2)21-5-6-22(32-31-21)25(26,27)28/h5-6,9-12,15,19H,4,7-8,13-14H2,1-3H3,(H,30,34)/t15-,19-/m1/s1 SIFMRPZFMXLARV-DNVCBOLYSA-N 322608 3-(5-ethyl-1,3- thiazol-2-yl)-5- {[(2R)-4- methyl- morpholin-2- yl]methoxy}-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl} benzamide::US10183937, Example 419::US10202369, Example 419::US10472354, Example 419 P2X purinoceptor 3 Homo sapiens 9.00 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322608 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322608&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397262 384225668 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683061 C[C@@H](NC(=O)c1cc(Oc2ccc(C)nc2)cc(c1)-c1ncc(C)s1)c1cnc(C)cn1 InChI=1S/C24H23N5O2S/c1-14-5-6-20(12-25-14)31-21-8-18(7-19(9-21)24-28-11-16(3)32-24)23(30)29-17(4)22-13-26-15(2)10-27-22/h5-13,17H,1-4H3,(H,29,30)/t17-/m1/s1 PZARJLLATJAKMG-QGZVFWFLSA-N 319964 N-[(1R)-1-(5-methylpyrazin-2-yl)ethyl]-3-[(6-methylpyridin-3-yl)oxy]-5-(5-methyl-1,3-thiazol-2-yl)benzamide::US10174016, Example 131::US10202369, Example 131::US10472354, Example 131 P2X purinoceptor 3 Homo sapiens 134 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319964 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319964&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397434 384223244 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683063 CC(NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ncc(F)cc1Cl InChI=1S/C22H21ClFN3O3S/c1-12-9-26-22(31-12)15-5-14(6-18(7-15)30-17-3-4-29-11-17)21(28)27-13(2)20-19(23)8-16(24)10-25-20/h5-10,13,17H,3-4,11H2,1-2H3,(H,27,28)/t13?,17-/m0/s1 YETTUNLUNMEXML-RUINGEJQSA-N 319965 N-[1-(3-Chloro-5-fluoropyridin-2-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(3S)-tetrahydrofuran-3-yloxy]benzamide::US10174016, Example 132::US10202369, Example 132::US10472354, Example 132 P2X purinoceptor 3 Homo sapiens 75.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319965 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319965&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397504 384223245 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683065 Cc1cnc(s1)-c1cc(O[C@H]2CCOC2)cc(c1)C(=O)NCc1ccc(C)nn1 InChI=1S/C21H22N4O3S/c1-13-3-4-17(25-24-13)11-22-20(26)15-7-16(21-23-10-14(2)29-21)9-19(8-15)28-18-5-6-27-12-18/h3-4,7-10,18H,5-6,11-12H2,1-2H3,(H,22,26)/t18-/m0/s1 VKRRMZCTKMLCQJ-SFHVURJKSA-N 319966 N-[(6-Methylpyridazin-3-yl)methyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(3S)-tetrahydrofuran-3-yloxy]benzamide::US10174016, Example 133::US10202369, Example 133::US10472354, Example 133 P2X purinoceptor 3 Homo sapiens 177 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319966 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319966&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397536 384223246 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683067 CC(NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ncc(Cl)cc1F InChI=1S/C22H21ClFN3O3S/c1-12-9-26-22(31-12)15-5-14(6-18(7-15)30-17-3-4-29-11-17)21(28)27-13(2)20-19(24)8-16(23)10-25-20/h5-10,13,17H,3-4,11H2,1-2H3,(H,27,28)/t13?,17-/m0/s1 DLODQDUFIVUCLQ-RUINGEJQSA-N 319967 N-[1-(5-Chloro-3-fluoropyridin-2-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(3S)-tetrahydrofuran-3-yloxy]benzamide::US10174016, Example 134::US10202369, Example 134::US10472354, Example 134 P2X purinoceptor 3 Homo sapiens 15.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319967 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319967&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397151 384223247 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683069 C[C@@H](NC(=O)c1cc(OC[C@H]2CCOC2)cc(c1)-c1ncc(s1)C1CCC1)c1ccc(C)nn1 InChI=1S/C26H30N4O3S/c1-16-6-7-23(30-29-16)17(2)28-25(31)20-10-21(26-27-13-24(34-26)19-4-3-5-19)12-22(11-20)33-15-18-8-9-32-14-18/h6-7,10-13,17-19H,3-5,8-9,14-15H2,1-2H3,(H,28,31)/t17-,18+/m1/s1 KRMAXJMLJAVOGJ-MSOLQXFVSA-N 319968 3-(5-Cyclobutyl-1,3-thiazol-2-yl)-N-[(1R)-1-(6-methylpyridazin-3-yl)ethyl]-5-[(3S)-tetrahydrofuran-3-ylmethoxy]benzamide::US10174016, Example 135::US10202369, Example 135::US10472354, Example 270 P2X purinoceptor 3 Homo sapiens 35.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319968 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319968&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397422 384223248 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683071 COCCOc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1cnc(C)nc1 InChI=1S/C21H24N4O3S/c1-13-10-24-21(29-13)17-7-16(8-19(9-17)28-6-5-27-4)20(26)25-14(2)18-11-22-15(3)23-12-18/h7-12,14H,5-6H2,1-4H3,(H,25,26)/t14-/m1/s1 NMXUVEDIBFBQMK-CQSZACIVSA-N 319969 3-(2-Methoxyethoxy)-N-[(1R)-1-(2-methylpyrimidin-5-yl)ethyl]-5-(5-methyl-1,3-thiazol-2-yl)benzamide::US10174016, Example 136::US10202369, Example 136::US10472354, Example 136 P2X purinoceptor 3 Homo sapiens 196 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319969 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319969&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397574 384223249 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683073 C[C@@H](NC(=O)c1cc(OC2CCN(CC2)C(=O)OC(C)(C)C)cc(c1)-c1ncc(C)s1)c1cnc(cn1)C(F)(F)F InChI=1S/C28H32F3N5O4S/c1-16-13-34-25(41-16)19-10-18(24(37)35-17(2)22-14-33-23(15-32-22)28(29,30)31)11-21(12-19)39-20-6-8-36(9-7-20)26(38)40-27(3,4)5/h10-15,17,20H,6-9H2,1-5H3,(H,35,37)/t17-/m1/s1 MOJZESVRLRZYMR-QGZVFWFLSA-N 346150 US10202369, Example 137::tert-Butyl 4-[3-(5-methyl-1,3-thiazol-2-yl)-5-({(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}carbamoyl)phenoxy]piperidine-1-carboxylate P2X purinoceptor 3 Homo sapiens 26.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=346150 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=346150&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134391357 385452201 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683075 C[C@@H](NC(=O)c1cc(OC2CCNCC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H24F3N5O2S/c1-13-10-28-21(34-13)16-7-15(8-19(9-16)33-18-3-5-27-6-4-18)20(32)31-14(2)17-11-29-22(30-12-17)23(24,25)26/h7-12,14,18,27H,3-6H2,1-2H3,(H,31,32)/t14-/m1/s1 AUEVADIQWKJNQT-CQSZACIVSA-N 319971 3-(5-Methyl-1,3-thiazol-2-yl)-5-(piperidin-4-yloxy)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 138::US10202369, Example 138::US10472354, Example 138 P2X purinoceptor 3 Homo sapiens 11.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319971 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319971&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397389 384223251 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683077 C[C@@H](NC(=O)c1cc(OC2CCN(C)CC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H26F3N5O2S/c1-14-11-28-22(35-14)17-8-16(9-20(10-17)34-19-4-6-32(3)7-5-19)21(33)31-15(2)18-12-29-23(30-13-18)24(25,26)27/h8-13,15,19H,4-7H2,1-3H3,(H,31,33)/t15-/m1/s1 BKNIRTNEYAOJDL-OAHLLOKOSA-N 319972 3-[(1-Methylpiperidin-4-yl)oxy]-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 139::US10202369, Example 139::US10472354, Example 215 P2X purinoceptor 3 Homo sapiens 8.00 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319972 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319972&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397521 384223252 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683079 CC(C)N1CCC(CC1)Oc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C26H30F3N5O2S/c1-15(2)34-7-5-21(6-8-34)36-22-10-18(9-19(11-22)24-30-12-16(3)37-24)23(35)33-17(4)20-13-31-25(32-14-20)26(27,28)29/h9-15,17,21H,5-8H2,1-4H3,(H,33,35)/t17-/m1/s1 JAJQPYKLEVBCIY-QGZVFWFLSA-N 319973 3-(5-Methyl-1,3-thiazol-2-yl)-5-{[1-(propan-2-yl)piperidin-4-yl]oxy}-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 140::US10202369, Example 140::US10472354, Example 140 P2X purinoceptor 3 Homo sapiens 33.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319973 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319973&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397336 384223253 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683081 C[C@@H](NC(=O)c1cc(O[C@@H]2CCN(C)C2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H24F3N5O2S/c1-13-9-27-21(34-13)16-6-15(7-19(8-16)33-18-4-5-31(3)12-18)20(32)30-14(2)17-10-28-22(29-11-17)23(24,25)26/h6-11,14,18H,4-5,12H2,1-3H3,(H,30,32)/t14-,18-/m1/s1 RNHSPVKPEXJLAD-RDTXWAMCSA-N 319974 3-{[(3R)-1-Methylpyrrolidin-3-yl]oxy}-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 141::US10202369, Example 141::US10472354, Example 141 P2X purinoceptor 3 Homo sapiens 43.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319974 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319974&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397272 384223254 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683083 C[C@@H](NC(=O)c1cc(O[C@H]2CCN(C)C2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H24F3N5O2S/c1-13-9-27-21(34-13)16-6-15(7-19(8-16)33-18-4-5-31(3)12-18)20(32)30-14(2)17-10-28-22(29-11-17)23(24,25)26/h6-11,14,18H,4-5,12H2,1-3H3,(H,30,32)/t14-,18+/m1/s1 RNHSPVKPEXJLAD-KDOFPFPSSA-N 319975 3-{[(3S)-1-Methylpyrrolidin-3-yl]oxy}-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 142::US10202369, Example 142::US10472354, Example 142 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319975 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319975&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397181 384223255 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683085 C[C@@H](NC(=O)c1cc(OC2CN(C)C2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C22H22F3N5O2S/c1-12-7-26-20(33-12)15-4-14(5-17(6-15)32-18-10-30(3)11-18)19(31)29-13(2)16-8-27-21(28-9-16)22(23,24)25/h4-9,13,18H,10-11H2,1-3H3,(H,29,31)/t13-/m1/s1 NFRXFSQBXDHWHW-CYBMUJFWSA-N 319976 3-[(1-Methylazetidin-3-yl)oxy]-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 143::US10202369, Example 143::US10472354, Example 143 P2X purinoceptor 3 Homo sapiens 84.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319976 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319976&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397519 384223256 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683087 C[C@H](NC(=O)c1cc(OCC#C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C21H17F3N4O2S/c1-4-5-30-17-7-14(6-15(8-17)19-25-9-12(2)31-19)18(29)28-13(3)16-10-26-20(27-11-16)21(22,23)24/h1,6-11,13H,5H2,2-3H3,(H,28,29)/t13-/m0/s1 BTRSFHCVZJPJKT-ZDUSSCGKSA-N 319977 3-(5-Methyl-1,3-thiazol-2-yl)-5-(prop-2-yn-1-yloxy)-N-{(1S)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 144::US10202369, Example 144::US10472354, Example 144 P2X purinoceptor 3 Homo sapiens 825 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319977 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319977&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397460 384223257 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683089 C[C@H](NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H23F3N4O3S/c1-13-10-27-21(34-13)16-7-15(8-19(9-16)33-18-3-5-32-6-4-18)20(31)30-14(2)17-11-28-22(29-12-17)23(24,25)26/h7-12,14,18H,3-6H2,1-2H3,(H,30,31)/t14-/m0/s1 WGQQHPGXKFPPTQ-AWEZNQCLSA-N 319978 3-(5-Methyl-1,3-thiazol-2-yl)-5-(tetrahydro-2H-pyran-4-yloxy)-N-{(1S)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 145::US10202369, Example 145::US10472354, Example 145 P2X purinoceptor 3 Homo sapiens 271 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319978 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319978&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397306 384223258 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683091 C[C@@H](NC(=O)c1cc(OC2CC3(C2)CN(C3)C(=O)OC(C)(C)C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C29H32F3N5O4S/c1-16-11-33-24(42-16)19-6-18(23(38)36-17(2)20-12-34-25(35-13-20)29(30,31)32)7-21(8-19)40-22-9-28(10-22)14-37(15-28)26(39)41-27(3,4)5/h6-8,11-13,17,22H,9-10,14-15H2,1-5H3,(H,36,38)/t17-/m1/s1 GOFUMWOIVIXXIJ-QGZVFWFLSA-N 319979 US10174016, Example 146::US10202369, Example 146::US10472354, Example 146::tert-butyl 6-[3-(5- methyl-1,3- thiazol-2-yl)-5- ({(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}carbamoyl) phenoxy]-2- azaspiro[3.3]heptane- 2-carboxylate P2X purinoceptor 3 Homo sapiens 45.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319979 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319979&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397340 384223259 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683093 C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1cnc(cn1)C(F)(F)F InChI=1S/C22H21F3N4O3S/c1-12-8-28-21(33-12)15-5-14(6-17(7-15)32-16-3-4-31-11-16)20(30)29-13(2)18-9-27-19(10-26-18)22(23,24)25/h5-10,13,16H,3-4,11H2,1-2H3,(H,29,30)/t13-,16-/m1/s1 DVMONFUPUPPMFW-CZUORRHYSA-N 319980 3-(5-methyl-1,3- thiazol-2-yl)-5- [(3R)- tetrahydrofuran-3- yloxy]-N-{(1R)-1- [5- (trifluoromethyl) pyrazin-2- yl]ethyl}benzamide::US10174016, Example 147::US10202369, Example 147::US10472354, Example 147 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319980 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319980&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397189 384223260 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683095 C[C@@H](NC(=O)c1cc(OC2COC2)cc(c1)-c1ncc(C)s1)c1ccc(nc1)C(F)(F)F InChI=1S/C22H20F3N3O3S/c1-12-8-27-21(32-12)16-5-15(6-17(7-16)31-18-10-30-11-18)20(29)28-13(2)14-3-4-19(26-9-14)22(23,24)25/h3-9,13,18H,10-11H2,1-2H3,(H,28,29)/t13-/m1/s1 NAXHTXVAPBZYNR-CYBMUJFWSA-N 319981 3-(5-methyl-1,3- thiazol-2-yl)-5- (oxetan-3-yloxy)- N-{(1R)-1-[6- (trifluoromethyl) pyridin-3- yl]ethyl}benzamide::US10174016, Example 148::US10202369, Example 148::US10472354, Example 148 P2X purinoceptor 3 Homo sapiens 33.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319981 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319981&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397138 384223261 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683097 C[C@@H](NC(=O)c1cc(OC23CCN(CC2)CC3)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C25H26F3N5O2S/c1-15-12-29-22(36-15)18-9-17(10-20(11-18)35-24-3-6-33(7-4-24)8-5-24)21(34)32-16(2)19-13-30-23(31-14-19)25(26,27)28/h9-14,16H,3-8H2,1-2H3,(H,32,34)/t16-/m1/s1 RAGSAJSSGMANHP-MRXNPFEDSA-N 319982 3-(1- azabicyclo[2.2.2] oct-4-yloxy)-5-(5- methyl-1,3- thiazol-3-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 149::US10202369, Example 149::US10472354, Example 149 P2X purinoceptor 3 Homo sapiens 21.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319982 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319982&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397715 384223262 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683099 C[C@@H](NC(=O)c1cc(OC2CCN(CC2)C(C)=O)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C25H26F3N5O3S/c1-14-11-29-23(37-14)18-8-17(9-21(10-18)36-20-4-6-33(7-5-20)16(3)34)22(35)32-15(2)19-12-30-24(31-13-19)25(26,27)28/h8-13,15,20H,4-7H2,1-3H3,(H,32,35)/t15-/m1/s1 ISMQQTCWBNBFKY-OAHLLOKOSA-N 319983 3-[(1- acetylpiperidin-4- yl)oxy]-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 150::US10202369, Example 150::US10472354, Example 150 P2X purinoceptor 3 Homo sapiens 12.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319983 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319983&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397215 384223263 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683101 C[C@@H](NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)F InChI=1S/C22H22F2N4O3S/c1-12-8-27-22(32-12)15-5-14(6-18(7-15)31-17-3-4-30-11-17)21(29)28-13(2)16-9-25-20(19(23)24)26-10-16/h5-10,13,17,19H,3-4,11H2,1-2H3,(H,28,29)/t13-,17+/m1/s1 AUVRCFBFFFYNAV-DYVFJYSZSA-N 319984 N-{(1R)-1-[2- (difluoromethyl) pyrimidin-5- yl]ethyl}-3-(5- methyl-1,3- thiazol-2-yl)-5- [(3S)- tetrahydrofuran-3- yloxy]benzamide::US10174016, Example 151::US10202369, Example 151::US10472354, Example 151 P2X purinoceptor 3 Homo sapiens 31.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319984 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319984&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397480 384223264 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683103 C[C@@H](NC(=O)c1cc(OC2COC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)F InChI=1S/C21H20F2N4O3S/c1-11-6-26-21(31-11)14-3-13(4-16(5-14)30-17-9-29-10-17)20(28)27-12(2)15-7-24-19(18(22)23)25-8-15/h3-8,12,17-18H,9-10H2,1-2H3,(H,27,28)/t12-/m1/s1 YTKWIWSPGJOVJL-GFCCVEGCSA-N 319985 N-{(1R)-1-[2- (difluoromethyl) pyrimidin-5- yl]ethyl}-3-(5- methyl-1,3- thiazol-2-yl)-5- (oxetan-3- yloxy)benzamide::US10174016, Example 152::US10202369, Example 152::US10472354, Example 152 P2X purinoceptor 3 Homo sapiens 45.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319985 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319985&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397528 384223265 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683105 C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)F InChI=1S/C22H22F2N4O3S/c1-12-8-27-22(32-12)15-5-14(6-18(7-15)31-17-3-4-30-11-17)21(29)28-13(2)16-9-25-20(19(23)24)26-10-16/h5-10,13,17,19H,3-4,11H2,1-2H3,(H,28,29)/t13-,17-/m1/s1 AUVRCFBFFFYNAV-CXAGYDPISA-N 319986 N-{(1R)-1-[2- (difluoromethyl) pyrimidin-5- yl]ethyl}-3-(5- methyl-1,3- thiazol-2-yl)-5- [(3R)- tetrahydrofuran-3- yloxy]benzamide::US10174016, Example 153::US10202369, Example 153::US10472354, Example 153 P2X purinoceptor 3 Homo sapiens 27.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319986 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319986&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397665 384223266 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683107 C[C@@H](NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)F InChI=1S/C23H24F2N4O3S/c1-13-10-28-23(33-13)16-7-15(8-19(9-16)32-18-3-5-31-6-4-18)22(30)29-14(2)17-11-26-21(20(24)25)27-12-17/h7-12,14,18,20H,3-6H2,1-2H3,(H,29,30)/t14-/m1/s1 RQWRZCMIWXGQJP-CQSZACIVSA-N 319987 N-{(1R)-1-[2- (difluoromethyl) pyrimidin-5- yl]ethyl}-3-(5- methyl-1,3- thiazol-2-yl)-5- (tetrahydro-2H- pyran-4- yloxy)benzamide::US10174016, Example 154::US10202369, Example 154::US10472354, Example 154 P2X purinoceptor 3 Homo sapiens 18.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319987 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319987&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397560 384223267 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683109 C[C@@H](NC(=O)c1cc(O[C@H]2CCCN(C)C2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H26F3N5O2S/c1-14-10-28-22(35-14)17-7-16(8-20(9-17)34-19-5-4-6-32(3)13-19)21(33)31-15(2)18-11-29-23(30-12-18)24(25,26)27/h7-12,15,19H,4-6,13H2,1-3H3,(H,31,33)/t15-,19+/m1/s1 DNVWWBHMIGZIMX-BEFAXECRSA-N 319988 3-{[(3S)-1- methylpiperidin-3- yl]oxy}-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 155::US10174016, Example 221::US10202369, Example 155::US10472354, Example 155 P2X purinoceptor 3 Homo sapiens 40.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319988 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319988&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397794 384223268 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683111 C[C@@H](NC(=O)c1cc(OC2(C)COC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C22H21F3N4O3S/c1-12-7-26-19(33-12)15-4-14(5-17(6-15)32-21(3)10-31-11-21)18(30)29-13(2)16-8-27-20(28-9-16)22(23,24)25/h4-9,13H,10-11H2,1-3H3,(H,29,30)/t13-/m1/s1 OYDLDEWAXBGGBJ-CYBMUJFWSA-N 319989 3-[(3- methyloxetan-3- yl)oxy]-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 156::US10202369, Example 156::US10472354, Example 156 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319989 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319989&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397627 384223269 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683113 C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ccc(nc1)C(F)(F)F InChI=1S/C23H22F3N3O3S/c1-13-10-28-22(33-13)17-7-16(8-19(9-17)32-18-5-6-31-12-18)21(30)29-14(2)15-3-4-20(27-11-15)23(24,25)26/h3-4,7-11,14,18H,5-6,12H2,1-2H3,(H,29,30)/t14-,18-/m1/s1 RHAXZNLWUJRHEA-RDTXWAMCSA-N 319990 3-(5-methyl-1,3- thiazol-2-yl)-5- [(3R)- tetrahydrofuran-3- yloxy]-N-{(1R)-1- [6- (trifluoromethyl) pyridin-3- yl]ethyl}benzamide::US10174016, Example 157::US10202369, Example 157::US10472354, Example 157 P2X purinoceptor 3 Homo sapiens 17.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319990 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319990&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397372 384223270 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683115 C[C@@H](NC(=O)c1cc(O[C@@H]2CCCN(C)C2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H26F3N5O2S/c1-14-10-28-22(35-14)17-7-16(8-20(9-17)34-19-5-4-6-32(3)13-19)21(33)31-15(2)18-11-29-23(30-12-18)24(25,26)27/h7-12,15,19H,4-6,13H2,1-3H3,(H,31,33)/t15-,19-/m1/s1 DNVWWBHMIGZIMX-DNVCBOLYSA-N 319991 3-{[(3R)-1- methylpiperidin-3- yl]oxy}-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 158::US10174016, Example 220::US10202369, Example 158::US10472354, Example 158 P2X purinoceptor 3 Homo sapiens 21.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319991 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319991&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397414 384223271 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683117 C[C@@H](NC(=O)c1cc(OCCn2cncn2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C22H20F3N7O2S/c1-13-8-27-20(35-13)16-5-15(6-18(7-16)34-4-3-32-12-26-11-30-32)19(33)31-14(2)17-9-28-21(29-10-17)22(23,24)25/h5-12,14H,3-4H2,1-2H3,(H,31,33)/t14-/m1/s1 HYNLHPVSAUUUKN-CQSZACIVSA-N 319992 3-(5-methyl-1,3- thiazol-2-yl)-5-[2- (1H-1,2,4-triazol- 1-yl)ethoxy]-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 159::US10202369, Example 159::US10472354, Example 159 P2X purinoceptor 3 Homo sapiens 28.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319992 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319992&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397126 384223272 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683119 C[C@@H](NC(=O)c1cc(OCCn2cncn2)cc(c1)-c1ncc(C)s1)c1ccc(nc1)C(F)(F)F InChI=1S/C23H21F3N6O2S/c1-14-10-29-22(35-14)18-7-17(8-19(9-18)34-6-5-32-13-27-12-30-32)21(33)31-15(2)16-3-4-20(28-11-16)23(24,25)26/h3-4,7-13,15H,5-6H2,1-2H3,(H,31,33)/t15-/m1/s1 ZEDPNXXTTLJFPM-OAHLLOKOSA-N 319993 3-(5-methyl-1,3- thiazol-2-yl)-5-[2- (1H-1,2,4-triazol- 1-yl)ethoxy]-N- {(1R)-1-[6- (trifluoromethyl) pyridin-3- yl]ethyl}benzamide::US10174016, Example 160::US10202369, Example 160::US10472354, Example 160 P2X purinoceptor 3 Homo sapiens 28.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319993 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319993&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397838 384223273 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683121 C[C@@H](NC(=O)c1cc(OC2COC2)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F InChI=1S/C21H19F3N4O3S/c1-11-8-25-20(32-11)14-5-13(6-15(7-14)31-16-9-30-10-16)19(29)26-12(2)17-3-4-18(28-27-17)21(22,23)24/h3-8,12,16H,9-10H2,1-2H3,(H,26,29)/t12-/m1/s1 GINDYDBHFAVPIL-GFCCVEGCSA-N 319994 3-(5-methyl-1,3- thiazol-2-yl)-5- (oxetan-3-yloxy)- N-{(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl}benzamide::US10174016, Example 161::US10202369, Example 161::US10472354, Example 161 P2X purinoceptor 3 Homo sapiens 32.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319994 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319994&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397757 384223274 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683123 CC(O)C(C)Oc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C22H23F3N4O3S/c1-11-8-26-20(33-11)16-5-15(6-18(7-16)32-14(4)13(3)30)19(31)29-12(2)17-9-27-21(28-10-17)22(23,24)25/h5-10,12-14,30H,1-4H3,(H,29,31)/t12-,13?,14?/m1/s1 FSGDRFBLPAILDE-IYXRBSQSSA-N 319995 3-{[3-hydroxybutan-2-yl]oxy}-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 162::US10174016, Example 338::US10202369, Example 339::US10472354, Example 338 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319995 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319995&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397269 384223275 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683125 CC(O)C(C)Oc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C22H23F3N4O3S/c1-11-8-26-20(33-11)16-5-15(6-18(7-16)32-14(4)13(3)30)19(31)29-12(2)17-9-27-21(28-10-17)22(23,24)25/h5-10,12-14,30H,1-4H3,(H,29,31)/t12-,13?,14?/m0/s1 FSGDRFBLPAILDE-HSBZDZAISA-N 319996 US10174016, Example 163::US10202369, Example 340::US10472354, Example 162 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319996 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319996&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134328174 384223276 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683127 C[C@@H](NC(=O)c1cc(OC2COC2)cc(c1)-c1ncc(C)s1)c1ccc(nc1)C(F)F InChI=1S/C22H21F2N3O3S/c1-12-8-26-22(31-12)16-5-15(6-17(7-16)30-18-10-29-11-18)21(28)27-13(2)14-3-4-19(20(23)24)25-9-14/h3-9,13,18,20H,10-11H2,1-2H3,(H,27,28)/t13-/m1/s1 VIFFUASYGYMCSF-CYBMUJFWSA-N 319997 N-{[(1R)-1-[6- (difluoromethyl) pyridin-3-yl]ethyl}-3- (5-methyl-1,3- thiazol-2-yl)-5- (oxetan-3- yloxy)benzamide::US10174016, Example 164::US10202369, Example 164::US10472354, Example 164 P2X purinoceptor 3 Homo sapiens 60.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319997 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319997&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397252 384223277 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683129 C[C@@H](NC(=O)c1cc(O[C@H]2C[C@@H](C2)N(C)C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H26F3N5O2S/c1-13-10-28-22(35-13)16-5-15(6-19(7-16)34-20-8-18(9-20)32(3)4)21(33)31-14(2)17-11-29-23(30-12-17)24(25,26)27/h5-7,10-12,14,18,20H,8-9H2,1-4H3,(H,31,33)/t14-,18-,20-/m1/s1 AGHYBRFMKRJHNY-LXGCGDOSSA-N 319998 3-{[trans-3- (dimethylamino) cyclobutyl]oxy}-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5-yl] ethyl}benzamide::US10174016, Example 165::US10202369, Example 165::US10472354, Example 165 P2X purinoceptor 3 Homo sapiens 81.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319998 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319998&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397549 384223278 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683131 Cc1cnc(s1)-c1cc(O[C@@H]2CCOC2)cc(c1)C(=O)NCc1cnc(nc1)C(F)(F)F InChI=1S/C21H19F3N4O3S/c1-12-7-26-19(32-12)15-4-14(5-17(6-15)31-16-2-3-30-11-16)18(29)25-8-13-9-27-20(28-10-13)21(22,23)24/h4-7,9-10,16H,2-3,8,11H2,1H3,(H,25,29)/t16-/m1/s1 MLKRPMMAEMGGNI-MRXNPFEDSA-N 319999 3-(5-methyl-1,3- thiazol-2-yl)-5- [(3R)- tetrahydrofuran-3- yloxy]-N-{[2- (trifluoromethyl) pyrimidin-5- yl]methyl}benzamide::US10174016, Example 166::US10202369, Example 166::US10472354, Example 166 P2X purinoceptor 3 Homo sapiens 40.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319999 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319999&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397360 384223279 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683133 Cc1cnc(s1)-c1cc(OC2COC2)cc(c1)C(=O)NCc1cnc(nc1)C(F)(F)F InChI=1S/C20H17F3N4O3S/c1-11-5-25-18(31-11)14-2-13(3-15(4-14)30-16-9-29-10-16)17(28)24-6-12-7-26-19(27-8-12)20(21,22)23/h2-5,7-8,16H,6,9-10H2,1H3,(H,24,28) AWMOXCQCRBHEDH-UHFFFAOYSA-N 320000 3-(5-methyl-1,3- thiazol-2-yl)-5- (oxetan-3-yloxy)- N-{[2- (trifluoromethyl) pyrimidin-5- yl]methyl}benzamide::US10174016, Example 167::US10202369, Example 167::US10472354, Example 167 P2X purinoceptor 3 Homo sapiens 72.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320000 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320000&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397228 384223280 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683135 C[C@@H](NC(=O)c1cc(O[C@H]2CN3CCC2CC3)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C25H26F3N5O2S/c1-14-10-29-23(36-14)18-7-17(8-20(9-18)35-21-13-33-5-3-16(21)4-6-33)22(34)32-15(2)19-11-30-24(31-12-19)25(26,27)28/h7-12,15-16,21H,3-6,13H2,1-2H3,(H,32,34)/t15-,21+/m1/s1 XGNFOBIXAZWFEF-VFNWGFHPSA-N 320001 3-[(3R)-1- azabicyclo[2.2.2] oct-3-yloxy]-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 168::US10202369, Example 168::US10472354, Example 168 P2X purinoceptor 3 Homo sapiens 19.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320001 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320001&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397190 384223281 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683137 CCc1cnc(s1)-c1cc(OC2COC2)cc(c1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C22H21F3N4O3S/c1-3-18-9-26-20(33-18)14-4-13(5-16(6-14)32-17-10-31-11-17)19(30)29-12(2)15-7-27-21(28-8-15)22(23,24)25/h4-9,12,17H,3,10-11H2,1-2H3,(H,29,30)/t12-/m1/s1 KJLXSAGNAKDMHX-GFCCVEGCSA-N 320002 3-(5-ethyl-1,3- thiazol-2-yl)-5- (oxetan-3-yloxy)- N-{(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 169::US10202369, Example 169::US10472354, Example 169 P2X purinoceptor 3 Homo sapiens 9.00 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320002 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320002&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397192 384223282 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683139 C[C@@H](NC(=O)c1cc(Oc2ccc(C)nn2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H19F3N6O2S/c1-12-4-5-19(32-31-12)34-18-7-15(6-16(8-18)21-27-9-13(2)35-21)20(33)30-14(3)17-10-28-22(29-11-17)23(24,25)26/h4-11,14H,1-3H3,(H,30,33)/t14-/m1/s1 YBWKZVABJNKBEG-CQSZACIVSA-N 320003 3-[(6- methylpyridazin-3- yl)oxy]-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 170::US10202369, Example 170::US10472354, Example 170 P2X purinoceptor 3 Homo sapiens 165 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320003 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320003&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397298 384223283 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683141 C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ccc(nc1)C(F)F InChI=1S/C23H23F2N3O3S/c1-13-10-27-23(32-13)17-7-16(8-19(9-17)31-18-5-6-30-12-18)22(29)28-14(2)15-3-4-20(21(24)25)26-11-15/h3-4,7-11,14,18,21H,5-6,12H2,1-2H3,(H,28,29)/t14-,18-/m1/s1 UIFKRKFOSZCXTP-RDTXWAMCSA-N 320004 N-{(1R)-1-[6- (difluoromethyl) pyridin-3-yl]ethyl}-3- (5-methyl-1,3- thiazol-2-yl)-5- [(3R)- tetrahydrofuran-3- yloxy]benzamide::US10174016, Example 171::US10202369, Example 171::US10472354, Example 171 P2X purinoceptor 3 Homo sapiens 26.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320004 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320004&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397544 384223284 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683143 C[C@@H](NC(=O)c1cc(O[C@H]2CN3CCC2CC3)cc(c1)-c1ncc(C)s1)c1ccc(nc1)C(F)(F)F InChI=1S/C26H27F3N4O2S/c1-15-12-31-25(36-15)20-9-19(10-21(11-20)35-22-14-33-7-5-17(22)6-8-33)24(34)32-16(2)18-3-4-23(30-13-18)26(27,28)29/h3-4,9-13,16-17,22H,5-8,14H2,1-2H3,(H,32,34)/t16-,22+/m1/s1 BTZKHRISYBAOIH-ZHRRBRCNSA-N 320005 3-[(3R)-1- azabicyclo[2.2.2] oct-3-yloxy]-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[6- (trifluoromethyl) pyridin-3- yl]ethyl}benzamide::US10174016, Example 172::US10202369, Example 172::US10472354, Example 172 P2X purinoceptor 3 Homo sapiens 31.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320005 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320005&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397643 384223285 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683145 CCc1cnc(s1)-c1cc(O[C@@H]2CN3CCC2CC3)cc(c1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C26H28F3N5O2S/c1-3-21-13-30-24(37-21)18-8-17(9-20(10-18)36-22-14-34-6-4-16(22)5-7-34)23(35)33-15(2)19-11-31-25(32-12-19)26(27,28)29/h8-13,15-16,22H,3-7,14H2,1-2H3,(H,33,35)/t15-,22-/m1/s1 SVMXJSAEFPTNIN-IVZQSRNASA-N 320006 3-[(3S)-1- azabicyclo[2.2.2] oct-3-yloxy]-5-(5- ethyl-1,3-thiazol- 2-yl)-N-{(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 173::US10202369, Example 173::US10472354, Example 173 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320006 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320006&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397592 384223286 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683147 CCc1cnc(s1)-c1cc(O[C@H]2CN3CCC2CC3)cc(c1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C26H28F3N5O2S/c1-3-21-13-30-24(37-21)18-8-17(9-20(10-18)36-22-14-34-6-4-16(22)5-7-34)23(35)33-15(2)19-11-31-25(32-12-19)26(27,28)29/h8-13,15-16,22H,3-7,14H2,1-2H3,(H,33,35)/t15-,22+/m1/s1 SVMXJSAEFPTNIN-QRQCRPRQSA-N 320007 3-[(3R)-1- azabicyclo[2.2.2] oct-3-yloxy]-5-(5- ethyl-1,3-thiazol- 2-yl)-N-{(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 174::US10202369, Example 174::US10472354, Example 174 P2X purinoceptor 3 Homo sapiens 11.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320007 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320007&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397479 384223287 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683149 C[C@@H](NC(=O)c1cc(O[C@@H]2CN3CCC2CC3)cc(c1)-c1ncc(C)s1)c1ccc(nc1)C(F)(F)F InChI=1S/C26H27F3N4O2S/c1-15-12-31-25(36-15)20-9-19(10-21(11-20)35-22-14-33-7-5-17(22)6-8-33)24(34)32-16(2)18-3-4-23(30-13-18)26(27,28)29/h3-4,9-13,16-17,22H,5-8,14H2,1-2H3,(H,32,34)/t16-,22-/m1/s1 BTZKHRISYBAOIH-OPAMFIHVSA-N 320008 3-[(3S)-1- azabicyclo[2.2.2] oct-3-yloxy]-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[6- (trifluoromethyl) pyridin-3- yl]ethyl}benzamide::US10174016, Example 175::US10202369, Example 175::US10472354, Example 175 P2X purinoceptor 3 Homo sapiens 23.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320008 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320008&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397558 384223288 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683151 C[C@@H](NC(=O)c1cc(Oc2nnc(C)s2)cc(c1)-c1ncc(C)s1)c1ccc(nc1)C(F)(F)F InChI=1S/C22H18F3N5O2S2/c1-11-9-27-20(33-11)16-6-15(7-17(8-16)32-21-30-29-13(3)34-21)19(31)28-12(2)14-4-5-18(26-10-14)22(23,24)25/h4-10,12H,1-3H3,(H,28,31)/t12-/m1/s1 IWXLKQRNUPTLAV-GFCCVEGCSA-N 320009 3-[(5-methyl- 1,3,4-thiadiazol-2- yl)oxy]-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[6- (trifluoromethyl) pyridin-3- yl]ethyl}benzamide::US10174016, Example 176::US10202369, Example 176::US10472354, Example 176 P2X purinoceptor 3 Homo sapiens 29.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320009 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320009&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397692 384223289 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683153 C[C@@H](NC(=O)c1cc(OC[C@H]2COCCO2)cc(c1)-c1ncc(C)s1)c1ccc(nc1)C(F)(F)F InChI=1S/C24H24F3N3O4S/c1-14-10-29-23(35-14)18-7-17(8-19(9-18)34-13-20-12-32-5-6-33-20)22(31)30-15(2)16-3-4-21(28-11-16)24(25,26)27/h3-4,7-11,15,20H,5-6,12-13H2,1-2H3,(H,30,31)/t15-,20-/m1/s1 LZEBVIBIWJOALL-FOIQADDNSA-N 320010 3-[(2R)-1,4-dioxan-2- ylmethoxy]-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[6- (trifluoromethyl) pyridin-3- yl]ethyl}benzamide::US10174016, Example 177::US10202369, Example 177::US10472354, Example 177 P2X purinoceptor 3 Homo sapiens 14.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320010 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320010&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397515 384223290 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683155 C[C@@H](NC(=O)c1cc(OC[C@H]2COCCO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H23F3N4O4S/c1-13-8-27-21(35-13)16-5-15(6-18(7-16)34-12-19-11-32-3-4-33-19)20(31)30-14(2)17-9-28-22(29-10-17)23(24,25)26/h5-10,14,19H,3-4,11-12H2,1-2H3,(H,30,31)/t14-,19-/m1/s1 NQEFGEXCJWOEFF-AUUYWEPGSA-N 320011 3-[(2R)-1,4-dioxan-2- ylmethoxy]-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 178::US10202369, Example 178::US10472354, Example 178 P2X purinoceptor 3 Homo sapiens 39.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320011 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320011&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397229 384223291 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683157 C[C@@H](NC(=O)c1cc(OC[C@H]2COCCO2)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F InChI=1S/C23H23F3N4O4S/c1-13-10-27-22(35-13)16-7-15(8-17(9-16)34-12-18-11-32-5-6-33-18)21(31)28-14(2)19-3-4-20(30-29-19)23(24,25)26/h3-4,7-10,14,18H,5-6,11-12H2,1-2H3,(H,28,31)/t14-,18-/m1/s1 PZDPWIRLHUGUOG-RDTXWAMCSA-N 320012 3-[(2R)-1,4-dioxan-2- ylmethoxy]-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3-yl]ethyl} benzamide::US10174016, Example 179::US10202369, Example 179::US10472354, Example 179 P2X purinoceptor 3 Homo sapiens 13.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320012 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320012&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397371 384223292 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683159 C[C@@H](NC(=O)c1cc(OC[C@@H]2COCCO2)cc(c1)-c1ncc(C)s1)c1ccc(nc1)C(F)(F)F InChI=1S/C24H24F3N3O4S/c1-14-10-29-23(35-14)18-7-17(8-19(9-18)34-13-20-12-32-5-6-33-20)22(31)30-15(2)16-3-4-21(28-11-16)24(25,26)27/h3-4,7-11,15,20H,5-6,12-13H2,1-2H3,(H,30,31)/t15-,20+/m1/s1 LZEBVIBIWJOALL-QRWLVFNGSA-N 320013 3-[(2S)-1,4-dioxan- 2-ylmethoxy]-5-(5- methyl-1,3-thiazol-2-yl)- N-{(1R)-1-[6- (trifluoromethyl)pyridin- 3-yl]ethyl}benzamide::US10174016, Example 180::US10202369, Example 180::US10472354, Example 180 P2X purinoceptor 3 Homo sapiens 31.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320013 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320013&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397137 384223293 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683161 C[C@@H](NC(=O)c1cc(OC[C@@H]2COCCO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H23F3N4O4S/c1-13-8-27-21(35-13)16-5-15(6-18(7-16)34-12-19-11-32-3-4-33-19)20(31)30-14(2)17-9-28-22(29-10-17)23(24,25)26/h5-10,14,19H,3-4,11-12H2,1-2H3,(H,30,31)/t14-,19+/m1/s1 NQEFGEXCJWOEFF-KUHUBIRLSA-N 320014 3-[(2S)-1,4-dioxan- 2-ylmethoxy]-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 181::US10202369, Example 181::US10472354, Example 181 P2X purinoceptor 3 Homo sapiens 19.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320014 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320014&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397128 384223294 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683163 C[C@@H](NC(=O)c1cc(OC[C@@H]2COCCO2)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F InChI=1S/C23H23F3N4O4S/c1-13-10-27-22(35-13)16-7-15(8-17(9-16)34-12-18-11-32-5-6-33-18)21(31)28-14(2)19-3-4-20(30-29-19)23(24,25)26/h3-4,7-10,14,18H,5-6,11-12H2,1-2H3,(H,28,31)/t14-,18+/m1/s1 PZDPWIRLHUGUOG-KDOFPFPSSA-N 320015 3-[(2S)-1,4-dioxan- 2-ylmethoxy]-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl}benzamide::US10174016, Example 182::US10202369, Example 182::US10472354, Example 182 P2X purinoceptor 3 Homo sapiens 63.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320015 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320015&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397642 384223295 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683165 CC(O)C(C)Oc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1ccc(nn1)C(F)(F)F InChI=1S/C22H23F3N4O3S/c1-11-10-26-21(33-11)16-7-15(8-17(9-16)32-14(4)13(3)30)20(31)27-12(2)18-5-6-19(29-28-18)22(23,24)25/h5-10,12-14,30H,1-4H3,(H,27,31)/t12-,13?,14?/m1/s1 LMHZXBDHIYABCN-IYXRBSQSSA-N 320016 Trans Isomer 1; 3- {[3-hydroxybutan- 2-yl]oxy}-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl}benzamide::US10174016, Example 183::US10202369, Example 230::US10472354, Example 231 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320016 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320016&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397175 384223296 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683167 CC(O)C(C)Oc1cc(cc(c1)-c1ncc(Cl)s1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C21H20ClF3N4O3S/c1-10(15-7-27-20(28-8-15)21(23,24)25)29-18(31)13-4-14(19-26-9-17(22)33-19)6-16(5-13)32-12(3)11(2)30/h4-12,30H,1-3H3,(H,29,31)/t10-,11?,12?/m1/s1 QTLJKKFADUZLKR-VOMCLLRMSA-N 320017 Trans Isomer 1; 3- (5-chloro-1,3- thiazol-2-yl)-5-{[3- hydroxybutan-2- yl]oxy}-N-{(1R)-1- [2-(trifluoromethyl) pyrimidin-5-yl]ethyl} benzamide::US10174016, Example 184::US10174016, Example 185::US10174016, Example 187::US10174016, Example 188::US10202369, Example 188::US10472354, Example 188 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320017 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320017&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397494 384223297 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683169 CC(O)C(C)Oc1cc(cc(c1)-c1ncc(Cl)s1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C21H20ClF3N4O3S/c1-10(15-7-27-20(28-8-15)21(23,24)25)29-18(31)13-4-14(19-26-9-17(22)33-19)6-16(5-13)32-12(3)11(2)30/h4-12,30H,1-3H3,(H,29,31)/t10-,11?,12?/m1/s1 QTLJKKFADUZLKR-VOMCLLRMSA-N 320017 Trans Isomer 1; 3- (5-chloro-1,3- thiazol-2-yl)-5-{[3- hydroxybutan-2- yl]oxy}-N-{(1R)-1- [2-(trifluoromethyl) pyrimidin-5-yl]ethyl} benzamide::US10174016, Example 184::US10174016, Example 185::US10174016, Example 187::US10174016, Example 188::US10202369, Example 188::US10472354, Example 188 P2X purinoceptor 3 Homo sapiens 4.00 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320017 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320017&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397494 384223297 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683171 CC(O)C(C)Oc1cc(cc(c1)-c1ncc(Cl)s1)C(=O)N[C@H](C)c1ccc(nc1)C(F)(F)F InChI=1S/C22H21ClF3N3O3S/c1-11(14-4-5-18(27-9-14)22(24,25)26)29-20(31)15-6-16(21-28-10-19(23)33-21)8-17(7-15)32-13(3)12(2)30/h4-13,30H,1-3H3,(H,29,31)/t11-,12?,13?/m1/s1 HTVWJAQZHONFAU-PNESKVBLSA-N 320019 Trans Isomer 1; 3- (5-chloro-1,3- thiazol-2-yl)-5-{[3- hydroxybutan-2- yl]oxy}-N-{(1R)-1- [6-(trifluoromethyl) pyridin-3-yl]ethyl} benzamide::US10174016, Example 186::US10174016, Example 189::US10202369, Example 189::US10472354, Example 189 P2X purinoceptor 3 Homo sapiens 10.00 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320019 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320019&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397322 384223298 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683173 CC(O)C(C)Oc1cc(cc(c1)-c1ncc(Cl)s1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C21H20ClF3N4O3S/c1-10(15-7-27-20(28-8-15)21(23,24)25)29-18(31)13-4-14(19-26-9-17(22)33-19)6-16(5-13)32-12(3)11(2)30/h4-12,30H,1-3H3,(H,29,31)/t10-,11?,12?/m1/s1 QTLJKKFADUZLKR-VOMCLLRMSA-N 320017 Trans Isomer 1; 3- (5-chloro-1,3- thiazol-2-yl)-5-{[3- hydroxybutan-2- yl]oxy}-N-{(1R)-1- [2-(trifluoromethyl) pyrimidin-5-yl]ethyl} benzamide::US10174016, Example 184::US10174016, Example 185::US10174016, Example 187::US10174016, Example 188::US10202369, Example 188::US10472354, Example 188 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320017 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320017&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397494 384223297 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683175 CC(O)C(C)Oc1cc(cc(c1)-c1ncc(Cl)s1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C21H20ClF3N4O3S/c1-10(15-7-27-20(28-8-15)21(23,24)25)29-18(31)13-4-14(19-26-9-17(22)33-19)6-16(5-13)32-12(3)11(2)30/h4-12,30H,1-3H3,(H,29,31)/t10-,11?,12?/m1/s1 QTLJKKFADUZLKR-VOMCLLRMSA-N 320017 Trans Isomer 1; 3- (5-chloro-1,3- thiazol-2-yl)-5-{[3- hydroxybutan-2- yl]oxy}-N-{(1R)-1- [2-(trifluoromethyl) pyrimidin-5-yl]ethyl} benzamide::US10174016, Example 184::US10174016, Example 185::US10174016, Example 187::US10174016, Example 188::US10202369, Example 188::US10472354, Example 188 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320017 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320017&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397494 384223297 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683177 CC(O)C(C)Oc1cc(cc(c1)-c1ncc(Cl)s1)C(=O)N[C@H](C)c1ccc(nc1)C(F)(F)F InChI=1S/C22H21ClF3N3O3S/c1-11(14-4-5-18(27-9-14)22(24,25)26)29-20(31)15-6-16(21-28-10-19(23)33-21)8-17(7-15)32-13(3)12(2)30/h4-13,30H,1-3H3,(H,29,31)/t11-,12?,13?/m1/s1 HTVWJAQZHONFAU-PNESKVBLSA-N 320019 Trans Isomer 1; 3- (5-chloro-1,3- thiazol-2-yl)-5-{[3- hydroxybutan-2- yl]oxy}-N-{(1R)-1- [6-(trifluoromethyl) pyridin-3-yl]ethyl} benzamide::US10174016, Example 186::US10174016, Example 189::US10202369, Example 189::US10472354, Example 189 P2X purinoceptor 3 Homo sapiens 8.00 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320019 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320019&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397322 384223298 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683179 C[C@@H](NC(=O)c1cc(OC2CCCN(C2)C(=O)OC(C)(C)C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C28H32F3N5O4S/c1-16-12-32-24(41-16)19-9-18(23(37)35-17(2)20-13-33-25(34-14-20)28(29,30)31)10-22(11-19)39-21-7-6-8-36(15-21)26(38)40-27(3,4)5/h9-14,17,21H,6-8,15H2,1-5H3,(H,35,37)/t17-,21?/m1/s1 GMVSECYUKAWWNE-OQHSHRKDSA-N 320023 US10174016, Example 190::US10202369, Example 190::US10472354, Example 190::tert-Butyl (3R)-3-[3-(5-methyl-1,3-thiazol-2-yl)-5-({(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}carbamoyl)phenoxy]piperidine-1-carboxylate, as a mixture of diastereoisomers P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320023 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320023&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134338447 384223299 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683181 CC#CCOc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1ccc(C)nn1 InChI=1S/C22H22N4O2S/c1-5-6-9-28-19-11-17(10-18(12-19)22-23-13-15(3)29-22)21(27)24-16(4)20-8-7-14(2)25-26-20/h7-8,10-13,16H,9H2,1-4H3,(H,24,27)/t16-/m1/s1 WEKOJPFCJMIPGB-MRXNPFEDSA-N 320024 3-(but-2-yn-1- yloxy)-N-[(1R)- 1-(6- methylpyridazin- 3- yl)ethyl]-5- (5-methyl- 1,3-thiazol-2-yl) benzamide::US10174016, Example 191::US10202369, Example 191::US10472354, Example 191 P2X purinoceptor 3 Homo sapiens 61.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320024 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320024&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397657 384223300 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683183 C[C@@H](NC(=O)c1cc(O[C@@H]2CN3CCC2CC3)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C25H26F3N5O2S/c1-14-10-29-23(36-14)18-7-17(8-20(9-18)35-21-13-33-5-3-16(21)4-6-33)22(34)32-15(2)19-11-30-24(31-12-19)25(26,27)28/h7-12,15-16,21H,3-6,13H2,1-2H3,(H,32,34)/t15-,21-/m1/s1 XGNFOBIXAZWFEF-QVKFZJNVSA-N 320025 3-[(3S)-1- azabicyclo[2.2.2] oct-3-yloxy]-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5-yl] ethyl} benzamide::US10174016, Example 192::US10202369, Example 192::US10472354, Example 192 P2X purinoceptor 3 Homo sapiens 12.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320025 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320025&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397263 384223301 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683185 C[C@H](NC(=O)c1cc(OC2COC2)cc(c1)-c1ncc(C)s1)c1nnc(s1)C(F)(F)F InChI=1S/C19H17F3N4O3S2/c1-9-6-23-17(30-9)12-3-11(4-13(5-12)29-14-7-28-8-14)15(27)24-10(2)16-25-26-18(31-16)19(20,21)22/h3-6,10,14H,7-8H2,1-2H3,(H,24,27)/t10-/m0/s1 CAKLWYTTWVXMCY-JTQLQIEISA-N 320027 US10174016, Example 194::US10202369, Example 193::US10472354, Example 193 P2X purinoceptor 3 Homo sapiens 2705 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320027 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320027&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 138374897 384223303 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683187 C[C@@H](NC(=O)c1cc(OC2COC2)cc(c1)-c1ncc(C)s1)c1nnc(s1)C(F)(F)F InChI=1S/C19H17F3N4O3S2/c1-9-6-23-17(30-9)12-3-11(4-13(5-12)29-14-7-28-8-14)15(27)24-10(2)16-25-26-18(31-16)19(20,21)22/h3-6,10,14H,7-8H2,1-2H3,(H,24,27)/t10-/m1/s1 CAKLWYTTWVXMCY-SNVBAGLBSA-N 320026 3-(5-Methyl-1,3-thiazol-2-yl)-5-(oxetan-3-yloxy)-N-{1-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]ethyl}benzamide::US10174016, Example 193::US10202369, Example 194::US10472354, Example 194 P2X purinoceptor 3 Homo sapiens 46.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320026 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320026&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 138374896 384223302 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683189 C[C@H](NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(C)s1)c1nnc(s1)C(F)(F)F InChI=1S/C21H21F3N4O3S2/c1-11-10-25-19(32-11)14-7-13(8-16(9-14)31-15-3-5-30-6-4-15)17(29)26-12(2)18-27-28-20(33-18)21(22,23)24/h7-10,12,15H,3-6H2,1-2H3,(H,26,29)/t12-/m0/s1 NWTVSPCFEGLAFO-LBPRGKRZSA-N 320029 US10174016, Example 196::US10202369, Example 195::US10472354, Example 195 P2X purinoceptor 3 Homo sapiens 380 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320029 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320029&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 138374899 384223305 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683191 C[C@@H](NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(C)s1)c1nnc(s1)C(F)(F)F InChI=1S/C21H21F3N4O3S2/c1-11-10-25-19(32-11)14-7-13(8-16(9-14)31-15-3-5-30-6-4-15)17(29)26-12(2)18-27-28-20(33-18)21(22,23)24/h7-10,12,15H,3-6H2,1-2H3,(H,26,29)/t12-/m1/s1 NWTVSPCFEGLAFO-GFCCVEGCSA-N 320028 3-(5-methyl-1,3-thiazol-2-yl)-5-(tetrahydro-2H-pyran-4-yloxy)-N-{1-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]ethyl}benzamide::US10174016, Example 195::US10202369, Example 196::US10472354, Example 196 P2X purinoceptor 3 Homo sapiens 19.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320028 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320028&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 138374898 384223304 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683193 C[C@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1nnc(s1)C(F)(F)F InChI=1S/C20H19F3N4O3S2/c1-10-8-24-18(31-10)13-5-12(6-15(7-13)30-14-3-4-29-9-14)16(28)25-11(2)17-26-27-19(32-17)20(21,22)23/h5-8,11,14H,3-4,9H2,1-2H3,(H,25,28)/t11-,14+/m0/s1 SHLRNWXFYHGFLL-SMDDNHRTSA-N 320031 US10174016, Example 198::US10202369, Example 197::US10472354, Example 197 P2X purinoceptor 3 Homo sapiens 1152 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320031 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320031&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 138374900 384223307 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683195 C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1nnc(s1)C(F)(F)F InChI=1S/C20H19F3N4O3S2/c1-10-8-24-18(31-10)13-5-12(6-15(7-13)30-14-3-4-29-9-14)16(28)25-11(2)17-26-27-19(32-17)20(21,22)23/h5-8,11,14H,3-4,9H2,1-2H3,(H,25,28)/t11-,14-/m1/s1 SHLRNWXFYHGFLL-BXUZGUMPSA-N 320030 3-(5-methyl-1,3-thiazol-2-yl)-5-[(3R)-tetrahydrofuran-3-yloxy]-N-{1-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]ethyl}benzamide::US10174016, Example 197::US10202369, Example 198::US10472354, Example 198 P2X purinoceptor 3 Homo sapiens 30.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320030 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320030&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397585 384223306 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683197 C[C@H](NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1nnc(s1)C(F)(F)F InChI=1S/C20H19F3N4O3S2/c1-10-8-24-18(31-10)13-5-12(6-15(7-13)30-14-3-4-29-9-14)16(28)25-11(2)17-26-27-19(32-17)20(21,22)23/h5-8,11,14H,3-4,9H2,1-2H3,(H,25,28)/t11-,14-/m0/s1 SHLRNWXFYHGFLL-FZMZJTMJSA-N 320033 US10174016, Example 200::US10202369, Example 199::US10472354, Example 199 P2X purinoceptor 3 Homo sapiens 1544 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320033 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320033&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 138374901 384223309 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683199 C[C@@H](NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1nnc(s1)C(F)(F)F InChI=1S/C20H19F3N4O3S2/c1-10-8-24-18(31-10)13-5-12(6-15(7-13)30-14-3-4-29-9-14)16(28)25-11(2)17-26-27-19(32-17)20(21,22)23/h5-8,11,14H,3-4,9H2,1-2H3,(H,25,28)/t11-,14+/m1/s1 SHLRNWXFYHGFLL-RISCZKNCSA-N 320032 3-(5-methyl-1,3-thiazol-2-yl)-5-[(3S)-tetrahydrofuran-3-yloxy]-N-{1-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]ethyl}benzamide::US10174016, Example 199::US10202369, Example 200::US10472354, Example 200 P2X purinoceptor 3 Homo sapiens 30.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320032 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320032&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397243 384223308 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683201 C[C@@H](NC(=O)c1cc(OC2CCNCC2)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F InChI=1S/C23H24F3N5O2S/c1-13-12-28-22(34-13)16-9-15(10-18(11-16)33-17-5-7-27-8-6-17)21(32)29-14(2)19-3-4-20(31-30-19)23(24,25)26/h3-4,9-12,14,17,27H,5-8H2,1-2H3,(H,29,32)/t14-/m1/s1 JTGZQMREWDOCMX-CQSZACIVSA-N 320034 3-(5-methyl-1,3-thiazol-2-yl)-5-(piperidin-4-yloxy)-N-{(1R)-1-[6-(trifluoromethyl)pyridazin-3-yl]ethyl}benzamide::US10174016, Example 201::US10202369, Example 201::US10472354, Example 201 P2X purinoceptor 3 Homo sapiens 16.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320034 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320034&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397404 384223310 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683203 C[C@@H](NC(=O)c1cc(OC2CC3(CNC3)C2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H24F3N5O2S/c1-13-8-29-21(35-13)16-3-15(4-18(5-16)34-19-6-23(7-19)11-28-12-23)20(33)32-14(2)17-9-30-22(31-10-17)24(25,26)27/h3-5,8-10,14,19,28H,6-7,11-12H2,1-2H3,(H,32,33)/t14-/m1/s1 KMHSWHWDZALJOK-CQSZACIVSA-N 320035 3-(2- azaspiro[3.3] hept- 6-yloxy)-5-(5- methyl-1,3- thiazol-2- yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 202::US10202369, Example 202::US10472354, Example 202 P2X purinoceptor 3 Homo sapiens 42.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320035 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320035&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397731 384223311 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683205 C[C@@H](NC(=O)c1cc(O[C@H]2CCNC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C22H22F3N5O2S/c1-12-8-27-20(33-12)15-5-14(6-18(7-15)32-17-3-4-26-11-17)19(31)30-13(2)16-9-28-21(29-10-16)22(23,24)25/h5-10,13,17,26H,3-4,11H2,1-2H3,(H,30,31)/t13-,17+/m1/s1 IUOVXWVSORDTAX-DYVFJYSZSA-N 320036 3-(5-methyl- 1,3-thiazol-2- yl)-5-[(3S)- pyrrolidin-3- yloxy]-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 203::US10202369, Example 203::US10472354, Example 203 P2X purinoceptor 3 Homo sapiens 36.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320036 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320036&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397829 384223312 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683207 C[C@@H](NC(=O)c1cc(OC2CCNCC2F)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H23F4N5O2S/c1-12-8-29-21(35-12)15-5-14(6-17(7-15)34-19-3-4-28-11-18(19)24)20(33)32-13(2)16-9-30-22(31-10-16)23(25,26)27/h5-10,13,18-19,28H,3-4,11H2,1-2H3,(H,32,33)/t13-,18?,19?/m1/s1 IVYMHMMQRKFONZ-XYJCDUHRSA-N 320037 3-{[3- fluoropiperidin- 4-yl]oxy}-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide, as a mixture of cis isomers::US10174016, Example 204::US10202369, Example 204::US10472354, Example 204 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320037 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320037&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397537 384223313 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683209 C[C@@H](NC(=O)c1cc(OC2CCCNC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H24F3N5O2S/c1-13-9-28-21(34-13)16-6-15(7-19(8-16)33-18-4-3-5-27-12-18)20(32)31-14(2)17-10-29-22(30-11-17)23(24,25)26/h6-11,14,18,27H,3-5,12H2,1-2H3,(H,31,32)/t14-,18?/m1/s1 YIMSHVDFMHXVTO-IKJXHCRLSA-N 322394 3-(5-methyl-1,3-thiazol-2-yl)-5-(piperidin-3-yloxy)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10183937, Example 205::US10202369, Example 205::US10472354, Example 206 P2X purinoceptor 3 Homo sapiens 4.00 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322394 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322394&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397478 384225457 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683211 C[C@H](NC(=O)c1cc(OC2CCCNC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H24F3N5O2S/c1-13-9-28-21(34-13)16-6-15(7-19(8-16)33-18-4-3-5-27-12-18)20(32)31-14(2)17-10-29-22(30-11-17)23(24,25)26/h6-11,14,18,27H,3-5,12H2,1-2H3,(H,31,32)/t14-,18?/m0/s1 YIMSHVDFMHXVTO-PIVQAISJSA-N 322395 US10183937, Example 206::US10202369, Example 206::US10472354, Example 205 P2X purinoceptor 3 Homo sapiens 31.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322395 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322395&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 138375407 384225458 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683213 C[C@@H](NC(=O)c1cc(OC2CCNC(C2)C(F)(F)F)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H23F6N5O2S/c1-12-9-32-21(38-12)15-5-14(6-18(7-15)37-17-3-4-31-19(8-17)23(25,26)27)20(36)35-13(2)16-10-33-22(34-11-16)24(28,29)30/h5-7,9-11,13,17,19,31H,3-4,8H2,1-2H3,(H,35,36)/t13-,17?,19?/m1/s1 RLIMWYRKEDYMPQ-UYCDIGJJSA-N 322396 3-(5-methyl-1,3-thiazol-2-yl)-5-{[2-(trifluoromethyl)piperidin-4-yl]oxy}-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10183937, Example 207::US10202369, Example 207::US10472354, Example 208 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322396 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322396&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397615 384225459 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683215 C[C@H](NC(=O)c1cc(OC2CCNC(C2)C(F)(F)F)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H23F6N5O2S/c1-12-9-32-21(38-12)15-5-14(6-18(7-15)37-17-3-4-31-19(8-17)23(25,26)27)20(36)35-13(2)16-10-33-22(34-11-16)24(28,29)30/h5-7,9-11,13,17,19,31H,3-4,8H2,1-2H3,(H,35,36)/t13-,17?,19?/m0/s1 RLIMWYRKEDYMPQ-LJSZUPLFSA-N 322397 US10183937, Example 208::US10202369, Example 208::US10472354, Example 207 P2X purinoceptor 3 Homo sapiens 2.00 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322397 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322397&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 138375408 384225460 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683217 C[C@@H](NC(=O)c1cc(OC2CC3CC2CN3C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C25H26F3N5O2S/c1-13-9-29-23(36-13)16-4-15(6-20(7-16)35-21-8-19-5-17(21)12-33(19)3)22(34)32-14(2)18-10-30-24(31-11-18)25(26,27)28/h4,6-7,9-11,14,17,19,21H,5,8,12H2,1-3H3,(H,32,34)/t14-,17?,19?,21?/m1/s1 BQHHMEMNTIGDMM-LXOQGKBISA-N 320042 3-{[2-methyl-2-azabicyclo[2.2.1]hept-5-yl]oxy}-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 209::US10202369, Example 209::US10472354, Example 209 P2X purinoceptor 3 Homo sapiens 30.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320042 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320042&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397807 384223318 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683219 C[C@@H](NC(=O)c1cc(OC2CCN(C)CC2)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F InChI=1S/C24H26F3N5O2S/c1-14-13-28-23(35-14)17-10-16(11-19(12-17)34-18-6-8-32(3)9-7-18)22(33)29-15(2)20-4-5-21(31-30-20)24(25,26)27/h4-5,10-13,15,18H,6-9H2,1-3H3,(H,29,33)/t15-/m1/s1 HKVPHDDZBSOGJS-OAHLLOKOSA-N 320043 3-[(1- methylpiperidin- 4-yl)oxy]-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl} benzamide::US10174016, Example 210::US10202369, Example 210::US10472354, Example 210 P2X purinoceptor 3 Homo sapiens 12.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320043 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320043&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397346 384223319 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683221 C[C@@H](NC(=O)c1cc(OC2CN(C)C2)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F InChI=1S/C22H22F3N5O2S/c1-12-9-26-21(33-12)15-6-14(7-16(8-15)32-17-10-30(3)11-17)20(31)27-13(2)18-4-5-19(29-28-18)22(23,24)25/h4-9,13,17H,10-11H2,1-3H3,(H,27,31)/t13-/m1/s1 IRYKBWGBPIOTOU-CYBMUJFWSA-N 320044 3-[(1- methylazetidin- 3-yl)oxy]-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl} benzamide::US10174016, Example 211::US10202369, Example 211::US10472354, Example 211 P2X purinoceptor 3 Homo sapiens 395 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320044 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320044&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397301 384223320 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683223 C[C@@H](NC(=O)c1cc(OC2CCN(C)CC2F)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H25F4N5O2S/c1-13-9-29-22(36-13)16-6-15(7-18(8-16)35-20-4-5-33(3)12-19(20)25)21(34)32-14(2)17-10-30-23(31-11-17)24(26,27)28/h6-11,14,19-20H,4-5,12H2,1-3H3,(H,32,34)/t14-,19?,20?/m1/s1 XFFHESNTQMKRAI-WPUWVODUSA-N 320045 3-[(3-fluoro-1- methylpiperidin-4- yl)oxy]-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide, as a single unknown isomer::US10174016, Example 212::US10202369, Example 212::US10472354, Example 212 P2X purinoceptor 3 Homo sapiens 4.00 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320045 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320045&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397317 384223321 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683225 C[C@@H](NC(=O)c1cc(OCC2(CC2)N(C)C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H26F3N5O2S/c1-14-10-28-21(35-14)17-7-16(8-19(9-17)34-13-23(5-6-23)32(3)4)20(33)31-15(2)18-11-29-22(30-12-18)24(25,26)27/h7-12,15H,5-6,13H2,1-4H3,(H,31,33)/t15-/m1/s1 GWFQILAPUSJPLG-OAHLLOKOSA-N 320046 3-{[1- (dimethylamino) cyclopropyl] methoxy}- 5-(5-methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 213::US10202369, Example 213::US10472354, Example 213 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320046 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320046&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397636 384223322 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683227 C[C@@H](NC(=O)c1cc(OC2CC3(C2)CN(C)C3)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C25H26F3N5O2S/c1-14-9-29-22(36-14)17-4-16(5-19(6-17)35-20-7-24(8-20)12-33(3)13-24)21(34)32-15(2)18-10-30-23(31-11-18)25(26,27)28/h4-6,9-11,15,20H,7-8,12-13H2,1-3H3,(H,32,34)/t15-/m1/s1 HKONVGJPBICXCZ-OAHLLOKOSA-N 320047 3-[(2-methyl-2- azaspiro [3.3]hept- 6-yl)oxy]-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 214::US10202369, Example 214::US10472354, Example 214 P2X purinoceptor 3 Homo sapiens 47.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320047 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320047&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397792 384223323 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683229 C[C@@H](NC(=O)c1cc(OC2CCN(C)CC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)F InChI=1S/C24H27F2N5O2S/c1-14-11-29-24(34-14)17-8-16(9-20(10-17)33-19-4-6-31(3)7-5-19)23(32)30-15(2)18-12-27-22(21(25)26)28-13-18/h8-13,15,19,21H,4-7H2,1-3H3,(H,30,32)/t15-/m1/s1 XUPWDJXPNRZNKL-OAHLLOKOSA-N 320048 N-{[(1R)-1-[2- (difluoromethyl) pyrimidin-5- yl]ethyl}-3-[(1- methylpiperidin- 4-yl)oxy]-5-(5- methyl-1,3- thiazol-2- yl)benzamide::US10174016, Example 215::US10202369, Example 215 P2X purinoceptor 3 Homo sapiens 16.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320048 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320048&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397133 384223324 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683231 C[C@@H](NC(=O)c1cc(O[C@@H]2C[C@@H]3CC[C@H](C2)N3C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C26H28F3N5O2S/c1-14-11-30-24(37-14)17-6-16(7-21(8-17)36-22-9-19-4-5-20(10-22)34(19)3)23(35)33-15(2)18-12-31-25(32-13-18)26(27,28)29/h6-8,11-13,15,19-20,22H,4-5,9-10H2,1-3H3,(H,33,35)/t15-,19-,20+,22+/m1/s1 BLUSEIUVKSVVTE-DZUANBCISA-N 320049 3-{[(3-endo)-8- methyl-8- azabicyclo[3.2.1] oct-3-yl]oxy}-5- (5-methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 216::US10202369, Example 216::US10472354, Example 216 P2X purinoceptor 3 Homo sapiens 14.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320049 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320049&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397314 384223325 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683233 C[C@@H](NC(=O)c1cc(O[C@H]2C[C@@H]3CC[C@H](C2)N3C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C26H28F3N5O2S/c1-14-11-30-24(37-14)17-6-16(7-21(8-17)36-22-9-19-4-5-20(10-22)34(19)3)23(35)33-15(2)18-12-31-25(32-13-18)26(27,28)29/h6-8,11-13,15,19-20,22H,4-5,9-10H2,1-3H3,(H,33,35)/t15-,19-,20+,22-/m1/s1 BLUSEIUVKSVVTE-BWKKGPAXSA-N 320050 3-{[(3-exo)-8- methyl-8- azabicyclo[3.2.1] oct-3-yl]oxy}- 5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 217::US10202369, Example 217::US10472354, Example 217 P2X purinoceptor 3 Homo sapiens 25.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320050 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320050&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397314 384223326 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683235 C[C@@H](NC(=O)c1cc(O[C@@H]2CC[C@H]3[C@H]2OCCN3C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C26H28F3N5O3S/c1-14-11-30-24(38-14)17-8-16(23(35)33-15(2)18-12-31-25(32-13-18)26(27,28)29)9-19(10-17)37-21-5-4-20-22(21)36-7-6-34(20)3/h8-13,15,20-22H,4-7H2,1-3H3,(H,33,35)/t15-,20+,21-,22-/m1/s1 FEZSJTOXTJNSGQ-WWGKXEARSA-N 320051 3-{[(4aS,7R, 7aR)-4- methyloctahydro- cyclopenta [b][1,4] oxazin-7-yl] oxy}-5- (5-methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 218::US10202369, Example 218::US10472354, Example 218 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320051 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320051&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397834 384223327 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683237 C[C@@H](NC(=O)c1cc(O[C@H]2CC[C@H]3[C@H]2OCCN3C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C26H28F3N5O3S/c1-14-11-30-24(38-14)17-8-16(23(35)33-15(2)18-12-31-25(32-13-18)26(27,28)29)9-19(10-17)37-21-5-4-20-22(21)36-7-6-34(20)3/h8-13,15,20-22H,4-7H2,1-3H3,(H,33,35)/t15-,20+,21+,22-/m1/s1 FEZSJTOXTJNSGQ-NSEXGNSCSA-N 320052 3-{[(4aS,7S, 7aR)-4- methylocta- hydro- cyclopenta[b] [1,4]oxazin- 7-yl]oxy}-5- (5-methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 219::US10202369, Example 219::US10472354, Example 219 P2X purinoceptor 3 Homo sapiens 2.00 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320052 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320052&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397597 384223328 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683239 C[C@@H](NC(=O)c1cc(OC2CCCN(C)C2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H26F3N5O2S/c1-14-10-28-22(35-14)17-7-16(8-20(9-17)34-19-5-4-6-32(3)13-19)21(33)31-15(2)18-11-29-23(30-12-18)24(25,26)27/h7-12,15,19H,4-6,13H2,1-3H3,(H,31,33)/t15-,19?/m1/s1 DNVWWBHMIGZIMX-NYRJJRHWSA-N 322409 3-[(1-methylpiperidin-3-yl)oxy]-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10183937, Example 220::US10202369, Example 220::US10472354, Example 221 P2X purinoceptor 3 Homo sapiens 62.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322409 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322409&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397678 384225471 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683241 C[C@H](NC(=O)c1cc(OC2CCCN(C)C2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H26F3N5O2S/c1-14-10-28-22(35-14)17-7-16(8-20(9-17)34-19-5-4-6-32(3)13-19)21(33)31-15(2)18-11-29-23(30-12-18)24(25,26)27/h7-12,15,19H,4-6,13H2,1-3H3,(H,31,33)/t15-,19?/m0/s1 DNVWWBHMIGZIMX-FUKCDUGKSA-N 322410 US10183937, Example 221::US10202369, Example 221::US10472354, Example 220 P2X purinoceptor 3 Homo sapiens 26.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322410 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322410&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 138375409 384225472 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683243 C[C@@H](NC(=O)c1cc(OC2CCN(C)C(C2)C(F)(F)F)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C25H25F6N5O2S/c1-13-10-32-22(39-13)16-6-15(21(37)35-14(2)17-11-33-23(34-12-17)25(29,30)31)7-19(8-16)38-18-4-5-36(3)20(9-18)24(26,27)28/h6-8,10-12,14,18,20H,4-5,9H2,1-3H3,(H,35,37)/t14-,18?,20?/m1/s1 ALJCLRFXPKVCLC-FHTBDLFWSA-N 322411 3-(5-methyl-1,3-thiazol-2-yl)-5-{[1-methyl-2-(trifluoromethyl)piperidin-4-yl]oxy}-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10183937, Example 222::US10202369, Example 222::US10472354, Example 223 P2X purinoceptor 3 Homo sapiens 4.00 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322411 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322411&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397819 384225473 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683245 C[C@H](NC(=O)c1cc(OC2CCN(C)C(C2)C(F)(F)F)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C25H25F6N5O2S/c1-13-10-32-22(39-13)16-6-15(21(37)35-14(2)17-11-33-23(34-12-17)25(29,30)31)7-19(8-16)38-18-4-5-36(3)20(9-18)24(26,27)28/h6-8,10-12,14,18,20H,4-5,9H2,1-3H3,(H,35,37)/t14-,18?,20?/m0/s1 ALJCLRFXPKVCLC-KLOIUYPJSA-N 322412 US10183937, Example 223::US10202369, Example 223::US10472354, Example 222 P2X purinoceptor 3 Homo sapiens 3.00 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322412 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322412&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 138375410 384225474 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683247 CC(C)N1CCC(CC1)Oc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1ccc(nn1)C(F)(F)F InChI=1S/C26H30F3N5O2S/c1-15(2)34-9-7-20(8-10-34)36-21-12-18(11-19(13-21)25-30-14-16(3)37-25)24(35)31-17(4)22-5-6-23(33-32-22)26(27,28)29/h5-6,11-15,17,20H,7-10H2,1-4H3,(H,31,35)/t17-/m1/s1 KRNISEGUXIGIEE-QGZVFWFLSA-N 320057 3-(5-Methyl-1,3-thiazol-2-yl)-5-{[1-(propan-2-yl)piperidin-4-yl]oxy}-N-{(1R)-1-[6-(trifluoromethyl)pyridazin-3-yl]ethyl}benzamide::US10174016, Example 224::US10202369, Example 224::US10472354, Example 224 P2X purinoceptor 3 Homo sapiens 9.00 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320057 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320057&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397429 384223331 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683249 CC(C)N1CC[C@@H](C1)Oc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C25H28F3N5O2S/c1-14(2)33-6-5-20(13-33)35-21-8-17(7-18(9-21)23-29-10-15(3)36-23)22(34)32-16(4)19-11-30-24(31-12-19)25(26,27)28/h7-12,14,16,20H,5-6,13H2,1-4H3,(H,32,34)/t16-,20+/m1/s1 AIBFTYSUMUVEOU-UZLBHIALSA-N 320058 3-(5-methyl- 1,3-thiazol- 2-yl)-5- {[(3S)-1- (propan-2- yl)pyrrolidin- 3-yl]oxy}-N- {(1R)-1- [2-(trifluoro- methyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 225::US10202369, Example 225::US10472354, Example 225 P2X purinoceptor 3 Homo sapiens 16.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320058 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320058&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397786 384223332 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683251 COC(=O)N1CCC(CC1)Oc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C25H26F3N5O4S/c1-14-11-29-22(38-14)17-8-16(9-20(10-17)37-19-4-6-33(7-5-19)24(35)36-3)21(34)32-15(2)18-12-30-23(31-13-18)25(26,27)28/h8-13,15,19H,4-7H2,1-3H3,(H,32,34)/t15-/m1/s1 XKGQQPBORAHPPR-OAHLLOKOSA-N 320059 Methyl 4-[3-(5-methyl-1,3-thiazol-2-yl)-5-({(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}carbamoyl)phenoxy]piperidine-1-carboxylate::US10174016, Example 226::US10202369, Example 226::US10472354, Example 226 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320059 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320059&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397135 384223333 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683253 CCOC(=O)N1CCC(CC1)Oc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C26H28F3N5O4S/c1-4-37-25(36)34-7-5-20(6-8-34)38-21-10-17(9-18(11-21)23-30-12-15(2)39-23)22(35)33-16(3)19-13-31-24(32-14-19)26(27,28)29/h9-14,16,20H,4-8H2,1-3H3,(H,33,35)/t16-/m1/s1 VLNWCOYPKWPZPZ-MRXNPFEDSA-N 320060 Ethyl 4-[3-(5-methyl-1,3-thiazol-2-yl)-5-({(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}carbamoyl)phenoxy]piperidine-1-carboxylate::US10174016, Example 227::US10202369, Example 227::US10472354, Example 227 P2X purinoceptor 3 Homo sapiens 13.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320060 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320060&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397225 384223334 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683255 CCOC(=O)N1CC[C@@H](C1)Oc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C25H26F3N5O4S/c1-4-36-24(35)33-6-5-19(13-33)37-20-8-16(7-17(9-20)22-29-10-14(2)38-22)21(34)32-15(3)18-11-30-23(31-12-18)25(26,27)28/h7-12,15,19H,4-6,13H2,1-3H3,(H,32,34)/t15-,19+/m1/s1 ZKABVOKJBCLEBM-BEFAXECRSA-N 320061 Ethyl (3S)-3-[3-(5-methyl-1,3-thiazol-2-yl)-5-({(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}carbamoyl)phenoxy]pyrrolidine-1-carboxylate::US10174016, Example 228::US10202369, Example 228::US10472354, Example 228 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320061 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320061&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134338446 384223335 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683257 CC(C)N1CC(C1)Oc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C24H26F3N5O2S/c1-13(2)32-11-20(12-32)34-19-6-16(5-17(7-19)22-28-8-14(3)35-22)21(33)31-15(4)18-9-29-23(30-10-18)24(25,26)27/h5-10,13,15,20H,11-12H2,1-4H3,(H,31,33)/t15-/m1/s1 ZGCTZBYNIOVVEC-OAHLLOKOSA-N 320062 3-(5-Methyl-1,3-thiazol-2-yl)-5-{[1-(propan-2-yl)azetidin-3-yl]oxy}-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 229::US10202369, Example 229::US10472354, Example 229 P2X purinoceptor 3 Homo sapiens 44.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320062 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320062&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397633 384223336 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683259 CC(O)C(C)Oc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1ccc(nn1)C(F)(F)F InChI=1S/C22H23F3N4O3S/c1-11-10-26-21(33-11)16-7-15(8-17(9-16)32-14(4)13(3)30)20(31)27-12(2)18-5-6-19(29-28-18)22(23,24)25/h5-10,12-14,30H,1-4H3,(H,27,31)/t12-,13?,14?/m1/s1 LMHZXBDHIYABCN-IYXRBSQSSA-N 320016 Trans Isomer 1; 3- {[3-hydroxybutan- 2-yl]oxy}-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl}benzamide::US10174016, Example 183::US10202369, Example 230::US10472354, Example 231 P2X purinoceptor 3 Homo sapiens 2.00 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320016 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320016&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397175 384223296 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683261 CC(O)C(C)Oc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@@H](C)c1ccc(nn1)C(F)(F)F InChI=1S/C22H23F3N4O3S/c1-11-10-26-21(33-11)16-7-15(8-17(9-16)32-14(4)13(3)30)20(31)27-12(2)18-5-6-19(29-28-18)22(23,24)25/h5-10,12-14,30H,1-4H3,(H,27,31)/t12-,13?,14?/m0/s1 LMHZXBDHIYABCN-HSBZDZAISA-N 322420 US10183937, Example 231::US10202369, Example 231::US10472354, Example 230 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322420 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322420&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 138375411 384225482 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683263 C[C@@H](NC(=O)c1cc(OC2CCS(=O)(=O)CC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H23F3N4O4S2/c1-13-10-27-21(35-13)16-7-15(8-19(9-16)34-18-3-5-36(32,33)6-4-18)20(31)30-14(2)17-11-28-22(29-12-17)23(24,25)26/h7-12,14,18H,3-6H2,1-2H3,(H,30,31)/t14-/m1/s1 JTWSIDWRGZSZAA-CQSZACIVSA-N 320065 3-[(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)oxy]-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 232::US10202369, Example 232::US10472354, Example 232 P2X purinoceptor 3 Homo sapiens 13.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320065 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320065&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397851 384223339 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683265 C[C@@H](NC(=O)c1cc(OC2CCS(=O)(=O)CC2)cc(c1)-c1ncc(C)s1)c1ccc(nc1)C(F)(F)F InChI=1S/C24H24F3N3O4S2/c1-14-12-29-23(35-14)18-9-17(10-20(11-18)34-19-5-7-36(32,33)8-6-19)22(31)30-15(2)16-3-4-21(28-13-16)24(25,26)27/h3-4,9-13,15,19H,5-8H2,1-2H3,(H,30,31)/t15-/m1/s1 BRFDVYQZWOBZCT-OAHLLOKOSA-N 320066 3-[(1,1- dioxidotetrahydro- 2H-thiopyran-4- yl)oxy]-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[6- (trifluoromethyl) pyridin-3-yl]ethyl} benzamide::US10174016, Example 233::US10202369, Example 233::US10472354, Example 233 P2X purinoceptor 3 Homo sapiens 16.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320066 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320066&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397139 384223340 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683267 CCc1cnc(s1)-c1cc(OC2CCOCC2)cc(c1)C(=O)N[C@H](C)c1cnc(C)cn1 InChI=1S/C24H28N4O3S/c1-4-21-13-27-24(32-21)18-9-17(10-20(11-18)31-19-5-7-30-8-6-19)23(29)28-16(3)22-14-25-15(2)12-26-22/h9-14,16,19H,4-8H2,1-3H3,(H,28,29)/t16-/m1/s1 DYONOLZVTXITOM-MRXNPFEDSA-N 320067 3-(5-ethyl-1,3- thiazol-2-yl)-N- [(1R)-1-(5- methylpyrazin-2- yl)ethyl]-5- (tetrahydro-2H- pyran-4- yloxy)benzamide::US10174016, Example 234::US10202369, Example 234::US10472354, Example 234 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320067 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320067&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397540 384223341 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683269 CCc1cnc(s1)-c1cc(OC2CCOCC2)cc(c1)C(=O)NCc1ccc(C)nn1 InChI=1S/C23H26N4O3S/c1-3-21-14-25-23(31-21)17-10-16(11-20(12-17)30-19-6-8-29-9-7-19)22(28)24-13-18-5-4-15(2)26-27-18/h4-5,10-12,14,19H,3,6-9,13H2,1-2H3,(H,24,28) BZFPOECMUNEZDH-UHFFFAOYSA-N 320068 3-(5-ethyl-1,3- thiazol-2-yl)-N-[(6- methylpyridazin-3- yl)methyl]-5- (tetrahydro-2H- pyran-4- yloxy)benzamide::US10174016, Example 235::US10202369, Example 235::US10472354, Example 235 P2X purinoceptor 3 Homo sapiens 18.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320068 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320068&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397197 384223342 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683271 C[C@@H](NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(s1)C1CCC1)c1cnc(C)cn1 InChI=1S/C26H30N4O3S/c1-16-13-28-23(14-27-16)17(2)30-25(31)19-10-20(26-29-15-24(34-26)18-4-3-5-18)12-22(11-19)33-21-6-8-32-9-7-21/h10-15,17-18,21H,3-9H2,1-2H3,(H,30,31)/t17-/m1/s1 QOZNFPLCSPWJRX-QGZVFWFLSA-N 320069 3-(5-cyclobutyl- 1,3-thiazol-2-yl)- N-[(1R)-1-(5- methylpyrazin-2- yl)ethyl]-5- (tetrahydro-2H- pyran-4- yloxy)benzamide::US10174016, Example 236::US10202369, Example 236::US10472354, Example 236 P2X purinoceptor 3 Homo sapiens 76.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320069 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320069&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397529 384223343 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683273 Cc1ccc(CNC(=O)c2cc(OC3CCOCC3)cc(c2)-c2ncc(s2)C2CCC2)nn1 InChI=1S/C25H28N4O3S/c1-16-5-6-20(29-28-16)14-26-24(30)18-11-19(25-27-15-23(33-25)17-3-2-4-17)13-22(12-18)32-21-7-9-31-10-8-21/h5-6,11-13,15,17,21H,2-4,7-10,14H2,1H3,(H,26,30) KYDTWNODFNIYNY-UHFFFAOYSA-N 320070 3-(5-cyclobutyl- 1,3-thiazol-2-yl)- N-[(6- methylpyridazin-3- yl)methyl]-5- (tetrahydro-2H- pyran-4- yloxy)benzamide::US10174016, Example 237::US10202369, Example 237::US10472354, Example 237 P2X purinoceptor 3 Homo sapiens 177 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320070 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320070&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397323 384223344 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683275 C[C@@H](NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(s1)C1CCC1)c1cnc(nc1)C(F)(F)F InChI=1S/C26H27F3N4O3S/c1-15(19-12-31-25(32-13-19)26(27,28)29)33-23(34)17-9-18(24-30-14-22(37-24)16-3-2-4-16)11-21(10-17)36-20-5-7-35-8-6-20/h9-16,20H,2-8H2,1H3,(H,33,34)/t15-/m1/s1 KTFAMKPHNDUKLL-OAHLLOKOSA-N 320071 3-(5-cyclobutyl- 1,3-thiazol-2-yl)-5- (tetrahydro-2H- pyran-4-yloxy)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 238::US10202369, Example 238::US10472354, Example 238 P2X purinoceptor 3 Homo sapiens 38.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320071 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320071&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397176 384223345 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683277 C[C@H](NC(=O)c1cc(OC[C@H]2CCOC2)cc(c1)-c1ncc(s1)C1CCC1)c1cnc(nc1)C(F)(F)F InChI=1S/C26H27F3N4O3S/c1-15(20-10-31-25(32-11-20)26(27,28)29)33-23(34)18-7-19(24-30-12-22(37-24)17-3-2-4-17)9-21(8-18)36-14-16-5-6-35-13-16/h7-12,15-17H,2-6,13-14H2,1H3,(H,33,34)/t15-,16-/m0/s1 JWRPHAGJMIAQMD-HOTGVXAUSA-N 320072 3-(5-cyclobutyl- 1,3-thiazol-2-yl)-5- [(3S)- tetrahydrofuran-3- ylmethoxy]-N- {(1S)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 239::US10202369, Example 239::US10472354, Example 239 P2X purinoceptor 3 Homo sapiens 1420 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320072 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320072&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397719 384223346 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683279 CCc1cnc(s1)-c1cc(O[C@@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1ccc(C)nn1 InChI=1S/C23H26N4O3S/c1-4-20-12-24-23(31-20)17-9-16(10-19(11-17)30-18-7-8-29-13-18)22(28)25-15(3)21-6-5-14(2)26-27-21/h5-6,9-12,15,18H,4,7-8,13H2,1-3H3,(H,25,28)/t15-,18-/m1/s1 OXXUGGORGDKECE-CRAIPNDOSA-N 320073 3-(5-ethyl-1,3- thiazol-2-yl)-N- [(1R)-1-(6- methylpyridazin-3- yl)ethyl]-5-[(3R)- tetrahydrofuran-3- yloxy]benzamide::US10174016, Example 240::US10202369, Example 249::US10472354, Example 240 P2X purinoceptor 3 Homo sapiens 12.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320073 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320073&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397178 384223347 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683281 CCc1cnc(s1)-c1cc(O[C@@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1cnc(C)cn1 InChI=1S/C23H26N4O3S/c1-4-20-11-26-23(31-20)17-7-16(8-19(9-17)30-18-5-6-29-13-18)22(28)27-15(3)21-12-24-14(2)10-25-21/h7-12,15,18H,4-6,13H2,1-3H3,(H,27,28)/t15-,18-/m1/s1 GGGFDTSSCKHCGY-CRAIPNDOSA-N 320074 3-(5-ethyl-1,3- thiazol-2-yl)-N- [(1R)-1-(5- methylpyrazin-2- yl)ethyl]-5-[(3R)- tetrahydrofuran-3- yloxy]benzamide::US10174016, Example 241::US10202369, Example 241::US10472354, Example 241 P2X purinoceptor 3 Homo sapiens 12.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320074 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320074&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397675 384223348 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683283 CCc1cnc(s1)-c1cc(O[C@@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C23H23F3N4O3S/c1-3-19-11-27-21(34-19)15-6-14(7-18(8-15)33-17-4-5-32-12-17)20(31)30-13(2)16-9-28-22(29-10-16)23(24,25)26/h6-11,13,17H,3-5,12H2,1-2H3,(H,30,31)/t13-,17-/m1/s1 CPHCWMUXIASQAI-CXAGYDPISA-N 320075 3-(5-ethyl-1,3- thiazol-2-yl)-5- [(3R)- tetrahydrofuran-3- yloxy]-N-{(1R)-1- [2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 242::US10202369, Example 242::US10472354, Example 242 P2X purinoceptor 3 Homo sapiens 2.00 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320075 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320075&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397732 384223349 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683285 C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(s1)C1CCC1)c1ccc(C)nn1 InChI=1S/C25H28N4O3S/c1-15-6-7-22(29-28-15)16(2)27-24(30)18-10-19(12-21(11-18)32-20-8-9-31-14-20)25-26-13-23(33-25)17-4-3-5-17/h6-7,10-13,16-17,20H,3-5,8-9,14H2,1-2H3,(H,27,30)/t16-,20-/m1/s1 GBDWWYIZWHGLEN-OXQOHEQNSA-N 320076 3-(5-cyclobutyl- 1,3-thiazol-2-yl)- N-[(1R)-1-(6- methylpyridazin-3- yl)ethyl]-5-[(3R)- tetrahydrofuran-3- yloxy]benzamide::US10174016, Example 243::US10202369, Example 243::US10472354, Example 243 P2X purinoceptor 3 Homo sapiens 117 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320076 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320076&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397824 384223350 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683287 C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(s1)C1CCC1)c1cnc(C)cn1 InChI=1S/C25H28N4O3S/c1-15-11-27-22(12-26-15)16(2)29-24(30)18-8-19(10-21(9-18)32-20-6-7-31-14-20)25-28-13-23(33-25)17-4-3-5-17/h8-13,16-17,20H,3-7,14H2,1-2H3,(H,29,30)/t16-,20-/m1/s1 FVGXVLFIHFQXPP-OXQOHEQNSA-N 320077 3-(5-cyclobutyl- 1,3-thiazol-2-yl)- N-[(1R)-1-(5- methylpyrazin-2- yl)ethyl]-5-[(3R)- tetrahydrofuran-3- yloxy]benzamide::US10174016, Example 244::US10202369, Example 244::US10472354, Example 244 P2X purinoceptor 3 Homo sapiens 75.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320077 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320077&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397416 384223351 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683289 C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(s1)C1CCC1)c1cnc(nc1)C(F)(F)F InChI=1S/C25H25F3N4O3S/c1-14(18-10-30-24(31-11-18)25(26,27)28)32-22(33)16-7-17(9-20(8-16)35-19-5-6-34-13-19)23-29-12-21(36-23)15-3-2-4-15/h7-12,14-15,19H,2-6,13H2,1H3,(H,32,33)/t14-,19-/m1/s1 IDGMWIXZIVCDCF-AUUYWEPGSA-N 320078 3-(5-cyclobutyl- 1,3-thiazol-2-yl)-5- [(3R)- tetrahydrofuran-3- yloxy]-N-{(1R)-1- [2-(trifluoromethyl) pyrimidin-5-yl] ethyl}benzamide::US10174016, Example 245::US10202369, Example 245::US10472354, Example 245 P2X purinoceptor 3 Homo sapiens 34.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320078 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320078&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397471 384223352 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683291 CC(C)c1cnc(s1)-c1cc(O[C@@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1ccc(C)nn1 InChI=1S/C24H28N4O3S/c1-14(2)22-12-25-24(32-22)18-9-17(10-20(11-18)31-19-7-8-30-13-19)23(29)26-16(4)21-6-5-15(3)27-28-21/h5-6,9-12,14,16,19H,7-8,13H2,1-4H3,(H,26,29)/t16-,19-/m1/s1 AZADLHFQZQVHQV-VQIMIIECSA-N 320079 N-[(1R)-1-(6- methylpyridazin-3- yl)ethyl]-3-[5- (propan-2-yl)-1,3- thiazol-2-yl]-5- [(3R)- tetrahydrofuran-3- yloxy]benzamide::US10174016, Example 246::US10202369, Example 246::US10472354, Example 246 P2X purinoceptor 3 Homo sapiens 266 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320079 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320079&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397745 384223353 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683293 CC(C)c1cnc(s1)-c1cc(O[C@@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1cnc(C)cn1 InChI=1S/C24H28N4O3S/c1-14(2)22-12-27-24(32-22)18-7-17(8-20(9-18)31-19-5-6-30-13-19)23(29)28-16(4)21-11-25-15(3)10-26-21/h7-12,14,16,19H,5-6,13H2,1-4H3,(H,28,29)/t16-,19-/m1/s1 ULUQVVVXKLITBV-VQIMIIECSA-N 320080 N-[(1R)-1-(5- methylpyrazin-2- yl)ethyl]-3-[5- (propan-2-yl)-1,3- thiazol-2-yl]-5- [(3R)- tetrahydrofuran-3- yloxy]benzamide::US10174016, Example 247::US10202369, Example 247::US10472354, Example 247 P2X purinoceptor 3 Homo sapiens 205 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320080 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320080&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397213 384223354 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683295 CC(C)c1cnc(s1)-c1cc(O[C@@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C24H25F3N4O3S/c1-13(2)20-11-28-22(35-20)16-6-15(7-19(8-16)34-18-4-5-33-12-18)21(32)31-14(3)17-9-29-23(30-10-17)24(25,26)27/h6-11,13-14,18H,4-5,12H2,1-3H3,(H,31,32)/t14-,18-/m1/s1 COCLYUAEQYUAPW-RDTXWAMCSA-N 320081 3-[5-(propan-2-yl)- 1,3-thiazol-2-yl]-5- [(3R)- tetrahydrofuran-3- yloxy]-N-{(1R)-1- [2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 248::US10202369, Example 248::US10472354, Example 248 P2X purinoceptor 3 Homo sapiens 44.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320081 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320081&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397577 384223355 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683297 CCc1cnc(s1)-c1cc(O[C@@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1ccc(C)nn1 InChI=1S/C23H26N4O3S/c1-4-20-12-24-23(31-20)17-9-16(10-19(11-17)30-18-7-8-29-13-18)22(28)25-15(3)21-6-5-14(2)26-27-21/h5-6,9-12,15,18H,4,7-8,13H2,1-3H3,(H,25,28)/t15-,18-/m1/s1 OXXUGGORGDKECE-CRAIPNDOSA-N 320073 3-(5-ethyl-1,3- thiazol-2-yl)-N- [(1R)-1-(6- methylpyridazin-3- yl)ethyl]-5-[(3R)- tetrahydrofuran-3- yloxy]benzamide::US10174016, Example 240::US10202369, Example 249::US10472354, Example 240 P2X purinoceptor 3 Homo sapiens 11.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320073 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320073&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397178 384223347 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683299 CCc1cnc(s1)-c1cc(O[C@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1cnc(C)cn1 InChI=1S/C23H26N4O3S/c1-4-20-11-26-23(31-20)17-7-16(8-19(9-17)30-18-5-6-29-13-18)22(28)27-15(3)21-12-24-14(2)10-25-21/h7-12,15,18H,4-6,13H2,1-3H3,(H,27,28)/t15-,18+/m1/s1 GGGFDTSSCKHCGY-QAPCUYQASA-N 320083 3-(5-ethyl-1,3- thiazol-2-yl)-N- [(1R)-1-(5- methylpyrazin-2- yl)ethyl]-5-[(3S)- tetrahydrofuran-3- yloxy]benzamide::US10174016, Example 250::US10202369, Example 250::US10472354, Example 250 P2X purinoceptor 3 Homo sapiens 15.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320083 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320083&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397653 384223357 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683301 CCc1cnc(s1)-c1cc(O[C@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C23H23F3N4O3S/c1-3-19-11-27-21(34-19)15-6-14(7-18(8-15)33-17-4-5-32-12-17)20(31)30-13(2)16-9-28-22(29-10-16)23(24,25)26/h6-11,13,17H,3-5,12H2,1-2H3,(H,30,31)/t13-,17+/m1/s1 CPHCWMUXIASQAI-DYVFJYSZSA-N 320084 3-(5-ethyl-1,3- thiazol-2-yl)-5- [(3S)- tetrahydrofuran-3- yloxy]-N-{(1R)-1- [2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 251::US10202369, Example 251::US10472354, Example 251 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320084 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320084&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397624 384223358 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683303 C[C@@H](NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(s1)C1CCC1)c1ccc(C)nn1 InChI=1S/C25H28N4O3S/c1-15-6-7-22(29-28-15)16(2)27-24(30)18-10-19(12-21(11-18)32-20-8-9-31-14-20)25-26-13-23(33-25)17-4-3-5-17/h6-7,10-13,16-17,20H,3-5,8-9,14H2,1-2H3,(H,27,30)/t16-,20+/m1/s1 GBDWWYIZWHGLEN-UZLBHIALSA-N 320085 3-(5-cyclobutyl- 1,3-thiazol-2-yl)- N-[(1R)-1-(6- methylpyridazin-3- yl)ethyl]-5-[(3S)- tetrahydrofuran-3- yloxy]benzamide::US10174016, Example 252::US10202369, Example 252::US10472354, Example 252 P2X purinoceptor 3 Homo sapiens 75.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320085 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320085&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397825 384223359 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683305 C[C@@H](NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(s1)C1CCC1)c1cnc(C)cn1 InChI=1S/C25H28N4O3S/c1-15-11-27-22(12-26-15)16(2)29-24(30)18-8-19(10-21(9-18)32-20-6-7-31-14-20)25-28-13-23(33-25)17-4-3-5-17/h8-13,16-17,20H,3-7,14H2,1-2H3,(H,29,30)/t16-,20+/m1/s1 FVGXVLFIHFQXPP-UZLBHIALSA-N 320086 3-(5-cyclobutyl- 1,3-thiazol-2-yl)- N-[(1R)-1-(5- methylpyrazin-2- yl)ethyl]-5-[(3S)- tetrahydrofuran-3- yloxy]benzamide::US10174016, Example 253::US10202369, Example 253::US10472354, Example 253 P2X purinoceptor 3 Homo sapiens 99.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320086 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320086&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397513 384223360 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683307 C[C@@H](NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(s1)C1CCC1)c1cnc(nc1)C(F)(F)F InChI=1S/C25H25F3N4O3S/c1-14(18-10-30-24(31-11-18)25(26,27)28)32-22(33)16-7-17(9-20(8-16)35-19-5-6-34-13-19)23-29-12-21(36-23)15-3-2-4-15/h7-12,14-15,19H,2-6,13H2,1H3,(H,32,33)/t14-,19+/m1/s1 IDGMWIXZIVCDCF-KUHUBIRLSA-N 320087 3-(5-cyclobutyl- 1,3-thiazol-2-yl)-5- [(3S)- tetrahydrofuran-3- yloxy]-N-{(1R)-1- [2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 254::US10202369, Example 254::US10472354, Example 254 P2X purinoceptor 3 Homo sapiens 28.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320087 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320087&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397641 384223361 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683309 CC(C)c1cnc(s1)-c1cc(O[C@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1ccc(C)nn1 InChI=1S/C24H28N4O3S/c1-14(2)22-12-25-24(32-22)18-9-17(10-20(11-18)31-19-7-8-30-13-19)23(29)26-16(4)21-6-5-15(3)27-28-21/h5-6,9-12,14,16,19H,7-8,13H2,1-4H3,(H,26,29)/t16-,19+/m1/s1 AZADLHFQZQVHQV-APWZRJJASA-N 320088 N-[(1R)-1-(6- methylpyridazin-3- yl)ethyl]-3-[5- (propan-2-yl)-1,3- thiazol-2-yl]-5- [(3S)- tetrahydrofuran-3- yloxy]benzamide::US10174016, Example 255::US10202369, Example 255::US10472354, Example 255 P2X purinoceptor 3 Homo sapiens 254 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320088 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320088&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397188 384223362 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683311 CC(C)c1cnc(s1)-c1cc(O[C@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1cnc(C)cn1 InChI=1S/C24H28N4O3S/c1-14(2)22-12-27-24(32-22)18-7-17(8-20(9-18)31-19-5-6-30-13-19)23(29)28-16(4)21-11-25-15(3)10-26-21/h7-12,14,16,19H,5-6,13H2,1-4H3,(H,28,29)/t16-,19+/m1/s1 ULUQVVVXKLITBV-APWZRJJASA-N 320089 N-[(1R)-1-(5- methylpyrazin-2- yl)ethyl]-3-[5- (propan-2-yl)-1,3- thiazol-2-yl]-5- [(3S)- tetrahydrofuran-3- yloxy]benzamide::US10174016, Example 256::US10202369, Example 256::US10472354, Example 256 P2X purinoceptor 3 Homo sapiens 136 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320089 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320089&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397239 384223363 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683313 CC(C)c1cnc(s1)-c1cc(O[C@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C24H25F3N4O3S/c1-13(2)20-11-28-22(35-20)16-6-15(7-19(8-16)34-18-4-5-33-12-18)21(32)31-14(3)17-9-29-23(30-10-17)24(25,26)27/h6-11,13-14,18H,4-5,12H2,1-3H3,(H,31,32)/t14-,18+/m1/s1 COCLYUAEQYUAPW-KDOFPFPSSA-N 320090 3-[5-(propan-2-yl)- 1,3-thiazol-2-yl]-5- [(3S)- tetrahydrofuran-3- yloxy]-N-{(1R)-1- [2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 257::US10202369, Example 257::US10472354, Example 257 P2X purinoceptor 3 Homo sapiens 47.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320090 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320090&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397534 384223364 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683315 CCc1cnc(s1)-c1cc(OC[C@@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1ccc(C)nn1 InChI=1S/C24H28N4O3S/c1-4-21-12-25-24(32-21)19-9-18(10-20(11-19)31-14-17-7-8-30-13-17)23(29)26-16(3)22-6-5-15(2)27-28-22/h5-6,9-12,16-17H,4,7-8,13-14H2,1-3H3,(H,26,29)/t16-,17-/m1/s1 CPQUPRVXRIYFHX-IAGOWNOFSA-N 320091 3-(5-ethyl-1,3- thiazol-2-yl)-N- [(1R)-1-(6- methylpyridazin-3- yl)ethyl]-5-[(3R)- tetrahydrofuran-3- ylmethoxy] benzamide::US10174016, Example 258::US10202369, Example 258::US10472354, Example 282 P2X purinoceptor 3 Homo sapiens 4.00 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320091 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320091&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397177 384223365 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683317 CCc1cnc(s1)-c1cc(OC[C@@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1cnc(C)cn1 InChI=1S/C24H28N4O3S/c1-4-21-11-27-24(32-21)19-7-18(8-20(9-19)31-14-17-5-6-30-13-17)23(29)28-16(3)22-12-25-15(2)10-26-22/h7-12,16-17H,4-6,13-14H2,1-3H3,(H,28,29)/t16-,17-/m1/s1 PZFOCXJBZDWRSU-IAGOWNOFSA-N 320092 3-(5-ethyl-1,3- thiazol-2-yl)-N- [(1R)-1-(5- methylpyrazin-2- yl)ethyl]-5-[(3R)- tetrahydrofuran-3- ylmethoxy] benzamide::US10174016, Example 259::US10202369, Example 259::US10472354, Example 283 P2X purinoceptor 3 Homo sapiens 10.00 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320092 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320092&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397564 384223366 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683319 CCc1cnc(s1)-c1cc(OC[C@@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C24H25F3N4O3S/c1-3-20-11-28-22(35-20)17-6-16(7-19(8-17)34-13-15-4-5-33-12-15)21(32)31-14(2)18-9-29-23(30-10-18)24(25,26)27/h6-11,14-15H,3-5,12-13H2,1-2H3,(H,31,32)/t14-,15-/m1/s1 VOKPPDDBRIDGES-HUUCEWRRSA-N 320093 3-(5-ethyl-1,3- thiazol-2-yl)-5- [(3R)- tetrahydrofuran-3- ylmethoxy]-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 260::US10202369, Example 260::US10472354, Example 260 P2X purinoceptor 3 Homo sapiens 2.00 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320093 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320093&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397266 384223367 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683321 C[C@@H](NC(=O)c1cc(OC[C@@H]2CCOC2)cc(c1)-c1ncc(s1)C1CCC1)c1ccc(C)nn1 InChI=1S/C26H30N4O3S/c1-16-6-7-23(30-29-16)17(2)28-25(31)20-10-21(26-27-13-24(34-26)19-4-3-5-19)12-22(11-20)33-15-18-8-9-32-14-18/h6-7,10-13,17-19H,3-5,8-9,14-15H2,1-2H3,(H,28,31)/t17-,18-/m1/s1 KRMAXJMLJAVOGJ-QZTJIDSGSA-N 320094 3-(5-cyclobutyl- 1,3-thiazol-2-yl)- N-[(1R)-1-(6- methylpyridazin-3- yl)ethyl]-5-[(3R)- tetrahydrofuran-3- ylmethoxy] benzamide::US10174016, Example 261::US10202369, Example 261::US10472354, Example 261 P2X purinoceptor 3 Homo sapiens 45.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320094 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320094&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397842 384223368 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683323 C[C@@H](NC(=O)c1cc(OC[C@@H]2CCOC2)cc(c1)-c1ncc(s1)C1CCC1)c1cnc(C)cn1 InChI=1S/C26H30N4O3S/c1-16-11-28-23(12-27-16)17(2)30-25(31)20-8-21(26-29-13-24(34-26)19-4-3-5-19)10-22(9-20)33-15-18-6-7-32-14-18/h8-13,17-19H,3-7,14-15H2,1-2H3,(H,30,31)/t17-,18-/m1/s1 ZBRXLMDGZXDHGV-QZTJIDSGSA-N 320095 3-(5-cyclobutyl- 1,3-thiazol-2-yl)- N-[(1R)-1-(5- methylpyrazin-2- yl)ethyl]-5-[(3R)- tetrahydrofuran-3- ylmethoxy] benzamide::US10174016, Example 262::US10202369, Example 262::US10472354, Example 262 P2X purinoceptor 3 Homo sapiens 85.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320095 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320095&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397383 384223369 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683325 C[C@@H](NC(=O)c1cc(OC[C@@H]2CCOC2)cc(c1)-c1ncc(s1)C1CCC1)c1cnc(nc1)C(F)(F)F InChI=1S/C26H27F3N4O3S/c1-15(20-10-31-25(32-11-20)26(27,28)29)33-23(34)18-7-19(24-30-12-22(37-24)17-3-2-4-17)9-21(8-18)36-14-16-5-6-35-13-16/h7-12,15-17H,2-6,13-14H2,1H3,(H,33,34)/t15-,16-/m1/s1 JWRPHAGJMIAQMD-HZPDHXFCSA-N 320096 3-(5-cyclobutyl- 1,3-thiazol-2-yl)-5- [(3R)- tetrahydrofuran-3- ylmethoxy]-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 263::US10202369, Example 263::US10472354, Example 263 P2X purinoceptor 3 Homo sapiens 33.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320096 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320096&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397122 384223370 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683327 CC(C)c1cnc(s1)-c1cc(OC[C@@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1ccc(C)nn1 InChI=1S/C25H30N4O3S/c1-15(2)23-12-26-25(33-23)20-9-19(10-21(11-20)32-14-18-7-8-31-13-18)24(30)27-17(4)22-6-5-16(3)28-29-22/h5-6,9-12,15,17-18H,7-8,13-14H2,1-4H3,(H,27,30)/t17-,18-/m1/s1 HVLSFPXITWENER-QZTJIDSGSA-N 320097 N-[(1R)-1-(6- methylpyridazin-3- yl)ethyl]-3-[5- (propan-2-yl)-1,3- thiazol-2-yl]-5- [(3R)- tetrahydrofuran-3- ylmethoxy] benzamide::US10174016, Example 264::US10202369, Example 264::US10472354, Example 264 P2X purinoceptor 3 Homo sapiens 81.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320097 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320097&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397620 384223371 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683329 CC(C)c1cnc(s1)-c1cc(OC[C@@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1cnc(C)cn1 InChI=1S/C25H30N4O3S/c1-15(2)23-12-28-25(33-23)20-7-19(8-21(9-20)32-14-18-5-6-31-13-18)24(30)29-17(4)22-11-26-16(3)10-27-22/h7-12,15,17-18H,5-6,13-14H2,1-4H3,(H,29,30)/t17-,18-/m1/s1 MWBSFWZECXCRJX-QZTJIDSGSA-N 320098 N-[(1R)-1-(5- methylpyrazin-2- yl)ethyl]-3-[5- (propan-2-yl)-1,3- thiazol-2-yl]-5- [(3R)- tetrahydrofuran-3- ylmethoxy] benzamide::US10174016, Example 265::US10202369, Example 265::US10472354, Example 265 P2X purinoceptor 3 Homo sapiens 104 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320098 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320098&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397233 384223372 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683331 CC(C)c1cnc(s1)-c1cc(OC[C@@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C25H27F3N4O3S/c1-14(2)21-11-29-23(36-21)18-6-17(7-20(8-18)35-13-16-4-5-34-12-16)22(33)32-15(3)19-9-30-24(31-10-19)25(26,27)28/h6-11,14-16H,4-5,12-13H2,1-3H3,(H,32,33)/t15-,16-/m1/s1 JZRSBKDBMGCFDH-HZPDHXFCSA-N 320099 3-[5-(propan-2-yl)- 1,3-thiazol-2-yl]-5- [(3R)- tetrahydrofuran-3- ylmethoxy]-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 266::US10202369, Example 266::US10472354, Example 266 P2X purinoceptor 3 Homo sapiens 41.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320099 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320099&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397337 384223373 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683333 CCc1cnc(s1)-c1cc(OC[C@H]2CCCO2)cc(c1)C(=O)N[C@H](C)c1ccc(C)nn1 InChI=1S/C24H28N4O3S/c1-4-21-13-25-24(32-21)18-10-17(11-20(12-18)31-14-19-6-5-9-30-19)23(29)26-16(3)22-8-7-15(2)27-28-22/h7-8,10-13,16,19H,4-6,9,14H2,1-3H3,(H,26,29)/t16-,19-/m1/s1 CEYURJDFNAEZIM-VQIMIIECSA-N 320100 3-(5-ethyl-1,3- thiazol-2-yl)-N- [(1R)-1-(6- methylpyridazin-3- yl)ethyl]-5-[(2R)- tetrahydrofuran-2- ylmethoxy] benzamide::US10174016, Example 267::US10202369, Example 276 P2X purinoceptor 3 Homo sapiens 14.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320100 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320100&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397219 384223374 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683335 CCc1cnc(s1)-c1cc(OC[C@H]2CCCO2)cc(c1)C(=O)N[C@H](C)c1cnc(C)cn1 InChI=1S/C24H28N4O3S/c1-4-21-12-27-24(32-21)18-8-17(9-20(10-18)31-14-19-6-5-7-30-19)23(29)28-16(3)22-13-25-15(2)11-26-22/h8-13,16,19H,4-7,14H2,1-3H3,(H,28,29)/t16-,19-/m1/s1 AKBLPSFNNBDTQK-VQIMIIECSA-N 320101 3-(5-ethyl-1,3- thiazol-2-yl)-N- [(1R)-1-(5- methylpyrazin-2- yl)ethyl]-5-[(2R)- tetrahydrofuran-2- ylmethoxy] benzamide::US10174016, Example 268::US10202369, Example 277 P2X purinoceptor 3 Homo sapiens 14.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320101 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320101&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397780 384223375 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683337 CCc1cnc(s1)-c1cc(OC[C@H]2CCCO2)cc(c1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C24H25F3N4O3S/c1-3-20-12-28-22(35-20)16-7-15(8-19(9-16)34-13-18-5-4-6-33-18)21(32)31-14(2)17-10-29-23(30-11-17)24(25,26)27/h7-12,14,18H,3-6,13H2,1-2H3,(H,31,32)/t14-,18-/m1/s1 IDFXYIYQWCENGA-RDTXWAMCSA-N 320102 3-(5-ethyl-1,3- thiazol-2-yl)-5- [(2R)- tetrahydrofuran-2- ylmethoxy]-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 269::US10202369, Example 278 P2X purinoceptor 3 Homo sapiens 2.00 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320102 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320102&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397217 384223376 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683339 C[C@@H](NC(=O)c1cc(OC[C@H]2CCCO2)cc(c1)-c1ncc(s1)C1CCC1)c1ccc(C)nn1 InChI=1S/C26H30N4O3S/c1-16-8-9-23(30-29-16)17(2)28-25(31)19-11-20(26-27-14-24(34-26)18-5-3-6-18)13-22(12-19)33-15-21-7-4-10-32-21/h8-9,11-14,17-18,21H,3-7,10,15H2,1-2H3,(H,28,31)/t17-,21-/m1/s1 NLLVDMMXBRFWGS-DYESRHJHSA-N 320103 3-(5-cyclobutyl- 1,3-thiazol-2-yl)- N-[(1R)-1-(6- methylpyridazin-3- yl)ethyl]-5-[(2R)- tetrahydrofuran-2- ylmethoxy] benzamide::US10174016, Example 270::US10202369, Example 270 P2X purinoceptor 3 Homo sapiens 25.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320103 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320103&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397499 384223377 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683341 C[C@@H](NC(=O)c1cc(OC[C@H]2CCCO2)cc(c1)-c1ncc(s1)C1CCC1)c1cnc(C)cn1 InChI=1S/C26H30N4O3S/c1-16-12-28-23(13-27-16)17(2)30-25(31)19-9-20(26-29-14-24(34-26)18-5-3-6-18)11-22(10-19)33-15-21-7-4-8-32-21/h9-14,17-18,21H,3-8,15H2,1-2H3,(H,30,31)/t17-,21-/m1/s1 BHRXSWOPMLFOCG-DYESRHJHSA-N 320104 3-(5-cyclobutyl- 1,3-thiazol-2-yl)- N-[(1R)-1-(5- methylpyrazin-2- yl)ethyl]-5-[(2R)- tetrahydrofuran-2- ylmethoxy] benzamide::US10174016, Example 271::US10202369, Example 271 P2X purinoceptor 3 Homo sapiens 45.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320104 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320104&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397691 384223378 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683343 C[C@@H](NC(=O)c1cc(OC[C@H]2CCCO2)cc(c1)-c1ncc(s1)C1CCC1)c1cnc(nc1)C(F)(F)F InChI=1S/C26H27F3N4O3S/c1-15(19-11-31-25(32-12-19)26(27,28)29)33-23(34)17-8-18(24-30-13-22(37-24)16-4-2-5-16)10-21(9-17)36-14-20-6-3-7-35-20/h8-13,15-16,20H,2-7,14H2,1H3,(H,33,34)/t15-,20-/m1/s1 ZERBIURYMMOJBU-FOIQADDNSA-N 320105 3-(5-cyclobutyl- 1,3-thiazol-2-yl)-5- [(2R)- tetrahydrofuran-2- ylmethoxy]-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 272::US10202369, Example 272 P2X purinoceptor 3 Homo sapiens 19.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320105 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320105&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397162 384223379 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683345 CC(C)c1cnc(s1)-c1cc(OC[C@H]2CCCO2)cc(c1)C(=O)N[C@H](C)c1ccc(C)nn1 InChI=1S/C25H30N4O3S/c1-15(2)23-13-26-25(33-23)19-10-18(11-21(12-19)32-14-20-6-5-9-31-20)24(30)27-17(4)22-8-7-16(3)28-29-22/h7-8,10-13,15,17,20H,5-6,9,14H2,1-4H3,(H,27,30)/t17-,20-/m1/s1 UAMKMSQRQBQFJK-YLJYHZDGSA-N 320106 N-[(1R)-1-(6- methylpyridazin-3- yl)ethyl]-3-[5- (propan-2-yl)-1,3- thiazol-2-yl]-5- [(2R)- tetrahydrofuran-2- ylmethoxy] benzamide::US10174016, Example 273::US10202369, Example 279 P2X purinoceptor 3 Homo sapiens 28.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320106 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320106&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397845 384223380 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683347 CC(C)c1cnc(s1)-c1cc(OC[C@H]2CCCO2)cc(c1)C(=O)N[C@H](C)c1cnc(C)cn1 InChI=1S/C25H30N4O3S/c1-15(2)23-13-28-25(33-23)19-8-18(9-21(10-19)32-14-20-6-5-7-31-20)24(30)29-17(4)22-12-26-16(3)11-27-22/h8-13,15,17,20H,5-7,14H2,1-4H3,(H,29,30)/t17-,20-/m1/s1 CNKRLRNKYMMPAE-YLJYHZDGSA-N 320107 N-[(1R)-1-(5- methylpyrazin-2- yl)ethyl]-3-[5- (propan-2-yl)-1,3- thiazol-2-yl]-5- [(2R)- tetrahydrofuran-2- ylmethoxy] benzamide::US10174016, Example 274::US10202369, Example 280 P2X purinoceptor 3 Homo sapiens 75.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320107 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320107&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397759 384223381 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683349 CC(C)c1cnc(s1)-c1cc(OC[C@H]2CCCO2)cc(c1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C25H27F3N4O3S/c1-14(2)21-12-29-23(36-21)17-7-16(8-20(9-17)35-13-19-5-4-6-34-19)22(33)32-15(3)18-10-30-24(31-11-18)25(26,27)28/h7-12,14-15,19H,4-6,13H2,1-3H3,(H,32,33)/t15-,19-/m1/s1 KTCCKJLURHRITN-DNVCBOLYSA-N 320108 3-[5-(propan-2-yl)- 1,3-thiazol-2-yl]-5- [(2R)- tetrahydrofuran-2- ylmethoxy]-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 275::US10202369, Example 281 P2X purinoceptor 3 Homo sapiens 21.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320108 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320108&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397795 384223382 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683351 CCc1cnc(s1)-c1cc(OC[C@H]2CCCO2)cc(c1)C(=O)N[C@H](C)c1ccc(C)nn1 InChI=1S/C24H28N4O3S/c1-4-21-13-25-24(32-21)18-10-17(11-20(12-18)31-14-19-6-5-9-30-19)23(29)26-16(3)22-8-7-15(2)27-28-22/h7-8,10-13,16,19H,4-6,9,14H2,1-3H3,(H,26,29)/t16-,19-/m1/s1 CEYURJDFNAEZIM-VQIMIIECSA-N 320100 3-(5-ethyl-1,3- thiazol-2-yl)-N- [(1R)-1-(6- methylpyridazin-3- yl)ethyl]-5-[(2R)- tetrahydrofuran-2- ylmethoxy] benzamide::US10174016, Example 267::US10202369, Example 276 P2X purinoceptor 3 Homo sapiens 10.00 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320100 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320100&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397219 384223374 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683353 CCc1cnc(s1)-c1cc(OC[C@H]2CCCO2)cc(c1)C(=O)N[C@H](C)c1cnc(C)cn1 InChI=1S/C24H28N4O3S/c1-4-21-12-27-24(32-21)18-8-17(9-20(10-18)31-14-19-6-5-7-30-19)23(29)28-16(3)22-13-25-15(2)11-26-22/h8-13,16,19H,4-7,14H2,1-3H3,(H,28,29)/t16-,19-/m1/s1 AKBLPSFNNBDTQK-VQIMIIECSA-N 320101 3-(5-ethyl-1,3- thiazol-2-yl)-N- [(1R)-1-(5- methylpyrazin-2- yl)ethyl]-5-[(2R)- tetrahydrofuran-2- ylmethoxy] benzamide::US10174016, Example 268::US10202369, Example 277 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320101 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320101&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397780 384223375 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683355 CCc1cnc(s1)-c1cc(OC[C@H]2CCCO2)cc(c1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C24H25F3N4O3S/c1-3-20-12-28-22(35-20)16-7-15(8-19(9-16)34-13-18-5-4-6-33-18)21(32)31-14(2)17-10-29-23(30-11-17)24(25,26)27/h7-12,14,18H,3-6,13H2,1-2H3,(H,31,32)/t14-,18-/m1/s1 IDFXYIYQWCENGA-RDTXWAMCSA-N 320102 3-(5-ethyl-1,3- thiazol-2-yl)-5- [(2R)- tetrahydrofuran-2- ylmethoxy]-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 269::US10202369, Example 278 P2X purinoceptor 3 Homo sapiens 2.00 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320102 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320102&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397217 384223376 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683357 CC(C)c1cnc(s1)-c1cc(OC[C@H]2CCCO2)cc(c1)C(=O)N[C@H](C)c1ccc(C)nn1 InChI=1S/C25H30N4O3S/c1-15(2)23-13-26-25(33-23)19-10-18(11-21(12-19)32-14-20-6-5-9-31-20)24(30)27-17(4)22-8-7-16(3)28-29-22/h7-8,10-13,15,17,20H,5-6,9,14H2,1-4H3,(H,27,30)/t17-,20-/m1/s1 UAMKMSQRQBQFJK-YLJYHZDGSA-N 320106 N-[(1R)-1-(6- methylpyridazin-3- yl)ethyl]-3-[5- (propan-2-yl)-1,3- thiazol-2-yl]-5- [(2R)- tetrahydrofuran-2- ylmethoxy] benzamide::US10174016, Example 273::US10202369, Example 279 P2X purinoceptor 3 Homo sapiens 115 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320106 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320106&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397845 384223380 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683359 CC(C)c1cnc(s1)-c1cc(OC[C@H]2CCCO2)cc(c1)C(=O)N[C@H](C)c1cnc(C)cn1 InChI=1S/C25H30N4O3S/c1-15(2)23-13-28-25(33-23)19-8-18(9-21(10-19)32-14-20-6-5-7-31-20)24(30)29-17(4)22-12-26-16(3)11-27-22/h8-13,15,17,20H,5-7,14H2,1-4H3,(H,29,30)/t17-,20-/m1/s1 CNKRLRNKYMMPAE-YLJYHZDGSA-N 320107 N-[(1R)-1-(5- methylpyrazin-2- yl)ethyl]-3-[5- (propan-2-yl)-1,3- thiazol-2-yl]-5- [(2R)- tetrahydrofuran-2- ylmethoxy] benzamide::US10174016, Example 274::US10202369, Example 280 P2X purinoceptor 3 Homo sapiens 51.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320107 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320107&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397759 384223381 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683361 CC(C)c1cnc(s1)-c1cc(OC[C@H]2CCCO2)cc(c1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C25H27F3N4O3S/c1-14(2)21-12-29-23(36-21)17-7-16(8-20(9-17)35-13-19-5-4-6-34-19)22(33)32-15(3)18-10-30-24(31-11-18)25(26,27)28/h7-12,14-15,19H,4-6,13H2,1-3H3,(H,32,33)/t15-,19-/m1/s1 KTCCKJLURHRITN-DNVCBOLYSA-N 320108 3-[5-(propan-2-yl)- 1,3-thiazol-2-yl]-5- [(2R)- tetrahydrofuran-2- ylmethoxy]-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 275::US10202369, Example 281 P2X purinoceptor 3 Homo sapiens 26.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320108 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320108&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397795 384223382 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683363 CCc1cnc(s1)-c1cc(OC[C@@H]2CCCO2)cc(c1)C(=O)N[C@H](C)c1ccc(C)nn1 InChI=1S/C24H28N4O3S/c1-4-21-13-25-24(32-21)18-10-17(11-20(12-18)31-14-19-6-5-9-30-19)23(29)26-16(3)22-8-7-15(2)27-28-22/h7-8,10-13,16,19H,4-6,9,14H2,1-3H3,(H,26,29)/t16-,19+/m1/s1 CEYURJDFNAEZIM-APWZRJJASA-N 320115 3-(5-ethyl-1,3- thiazol-2-yl)-N- [(1R)-1-(6- methylpyridazin-3- yl)ethyl]-5-[(2S)- tetrahydrofuran-2- ylmethoxy] benzamide::US10174016, Example 282::US10202369, Example 282 P2X purinoceptor 3 Homo sapiens 8.00 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320115 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320115&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397632 384223389 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683365 CCc1cnc(s1)-c1cc(OC[C@@H]2CCCO2)cc(c1)C(=O)N[C@H](C)c1cnc(C)cn1 InChI=1S/C24H28N4O3S/c1-4-21-12-27-24(32-21)18-8-17(9-20(10-18)31-14-19-6-5-7-30-19)23(29)28-16(3)22-13-25-15(2)11-26-22/h8-13,16,19H,4-7,14H2,1-3H3,(H,28,29)/t16-,19+/m1/s1 AKBLPSFNNBDTQK-APWZRJJASA-N 320116 3-(5-ethyl-1,3- thiazol-2-yl)-N- [(1R)-1-(5- methylpyrazin-2- yl)ethyl]-5-[(2S)- tetrahydrofuran-2- ylmethoxy] benzamide::US10174016, Example 283::US10202369, Example 283 P2X purinoceptor 3 Homo sapiens 10.00 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320116 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320116&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397578 384223390 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683367 CCc1cnc(s1)-c1cc(OC[C@@H]2CCCO2)cc(c1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C24H25F3N4O3S/c1-3-20-12-28-22(35-20)16-7-15(8-19(9-16)34-13-18-5-4-6-33-18)21(32)31-14(2)17-10-29-23(30-11-17)24(25,26)27/h7-12,14,18H,3-6,13H2,1-2H3,(H,31,32)/t14-,18+/m1/s1 IDFXYIYQWCENGA-KDOFPFPSSA-N 320117 3-(5-ethyl-1,3- thiazol-2-yl)-5- [(2S)- tetrahydrofuran-2- ylmethoxy]-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 284::US10202369, Example 284::US10472354, Example 284 P2X purinoceptor 3 Homo sapiens 4.00 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320117 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320117&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397623 384223391 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683369 C[C@@H](NC(=O)c1cc(OC[C@@H]2CCCO2)cc(c1)-c1ncc(s1)C1CCC1)c1ccc(C)nn1 InChI=1S/C26H30N4O3S/c1-16-8-9-23(30-29-16)17(2)28-25(31)19-11-20(26-27-14-24(34-26)18-5-3-6-18)13-22(12-19)33-15-21-7-4-10-32-21/h8-9,11-14,17-18,21H,3-7,10,15H2,1-2H3,(H,28,31)/t17-,21+/m1/s1 NLLVDMMXBRFWGS-UTKZUKDTSA-N 320118 3-(5-cyclobutyl- 1,3-thiazol-2-yl)- N-[(1R)-1-(6- methylpyridazin-3- yl)ethyl]-5-[(2S)- tetrahydrofuran-2- ylmethoxy] benzamide::US10174016, Example 285::US10202369, Example 285::US10472354, Example 285 P2X purinoceptor 3 Homo sapiens 113 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320118 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320118&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397163 384223392 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683371 C[C@@H](NC(=O)c1cc(OC[C@@H]2CCCO2)cc(c1)-c1ncc(s1)C1CCC1)c1cnc(C)cn1 InChI=1S/C26H30N4O3S/c1-16-12-28-23(13-27-16)17(2)30-25(31)19-9-20(26-29-14-24(34-26)18-5-3-6-18)11-22(10-19)33-15-21-7-4-8-32-21/h9-14,17-18,21H,3-8,15H2,1-2H3,(H,30,31)/t17-,21+/m1/s1 BHRXSWOPMLFOCG-UTKZUKDTSA-N 320119 3-(5-cyclobutyl- 1,3-thiazol-2-yl)- N-[(1R)-1-(5- methylpyrazin-2- yl)ethyl]-5-[(2S)- tetrahydrofuran-2- ylmethoxy]benzamide::US10174016, Example 286::US10202369, Example 286::US10472354, Example 286 P2X purinoceptor 3 Homo sapiens 87.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320119 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320119&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397754 384223393 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683373 C[C@@H](NC(=O)c1cc(OC[C@@H]2CCCO2)cc(c1)-c1ncc(s1)C1CCC1)c1cnc(nc1)C(F)(F)F InChI=1S/C26H27F3N4O3S/c1-15(19-11-31-25(32-12-19)26(27,28)29)33-23(34)17-8-18(24-30-13-22(37-24)16-4-2-5-16)10-21(9-17)36-14-20-6-3-7-35-20/h8-13,15-16,20H,2-7,14H2,1H3,(H,33,34)/t15-,20+/m1/s1 ZERBIURYMMOJBU-QRWLVFNGSA-N 320120 3-(5-cyclobutyl- 1,3-thiazol-2-yl)-5- [(2S)- tetrahydrofuran-2- ylmethoxy]-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 287::US10202369, Example 287::US10472354, Example 287 P2X purinoceptor 3 Homo sapiens 35.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320120 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320120&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397159 384223394 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683375 CC(C)c1cnc(s1)-c1cc(OC[C@@H]2CCCO2)cc(c1)C(=O)N[C@H](C)c1ccc(C)nn1 InChI=1S/C25H30N4O3S/c1-15(2)23-13-26-25(33-23)19-10-18(11-21(12-19)32-14-20-6-5-9-31-20)24(30)27-17(4)22-8-7-16(3)28-29-22/h7-8,10-13,15,17,20H,5-6,9,14H2,1-4H3,(H,27,30)/t17-,20+/m1/s1 UAMKMSQRQBQFJK-XLIONFOSSA-N 320121 N-[(1R)-1-(6- methylpyridazin-3- yl)ethyl]-3-[5- (propan-2-yl)-1,3- thiazol-2-yl]-5- [(2S)- tetrahydrofuran-2- ylmethoxy] benzamide::US10174016, Example 288::US10202369, Example 288::US10472354, Example 288 P2X purinoceptor 3 Homo sapiens 150 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320121 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320121&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397738 384223395 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683377 CC(C)c1cnc(s1)-c1cc(OC[C@@H]2CCCO2)cc(c1)C(=O)N[C@H](C)c1cnc(C)cn1 InChI=1S/C25H30N4O3S/c1-15(2)23-13-28-25(33-23)19-8-18(9-21(10-19)32-14-20-6-5-7-31-20)24(30)29-17(4)22-12-26-16(3)11-27-22/h8-13,15,17,20H,5-7,14H2,1-4H3,(H,29,30)/t17-,20+/m1/s1 CNKRLRNKYMMPAE-XLIONFOSSA-N 320122 N-[(1R)-1-(5- methylpyrazin-2- yl)ethyl]-3-[5- (propan-2-yl)-1,3- thiazol-2-yl]-5- [(2S)- tetrahydrofuran-2- ylmethoxy]benzamide::US10174016, Example 289::US10202369, Example 289::US10472354, Example 289 P2X purinoceptor 3 Homo sapiens 192 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320122 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320122&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397419 384223396 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683379 CC(C)c1cnc(s1)-c1cc(OC[C@@H]2CCCO2)cc(c1)C(=O)N[C@H](C)c1ccc(nc1)C(F)(F)F InChI=1S/C26H28F3N3O3S/c1-15(2)22-13-31-25(36-22)19-9-18(10-21(11-19)35-14-20-5-4-8-34-20)24(33)32-16(3)17-6-7-23(30-12-17)26(27,28)29/h6-7,9-13,15-16,20H,4-5,8,14H2,1-3H3,(H,32,33)/t16-,20+/m1/s1 USOMQOKPGJTCRC-UZLBHIALSA-N 346303 3-[5-(propan- 2-yl)- 1,3-thiazol-2-yl]- 5-[(2S)- tetrahydrofuran-2- ylmethoxy]-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}::US10202369, Example 290 P2X purinoceptor 3 Homo sapiens 31.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=346303 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=346303&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134391358 385452349 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683381 C[C@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C22H21F3N4O3S/c1-12-8-26-20(33-12)15-5-14(6-18(7-15)32-17-3-4-31-11-17)19(30)29-13(2)16-9-27-21(28-10-16)22(23,24)25/h5-10,13,17H,3-4,11H2,1-2H3,(H,29,30)/t13-,17+/m0/s1 GTQPEQGDLVSFJO-SUMWQHHRSA-N 320124 3-(5-methyl-1,3- thiazol-2-yl)-5- [(3R)- tetrahydrofuran-3- yloxy]-N-{(1S)-1- [2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 291::US10202369, Example 291 P2X purinoceptor 3 Homo sapiens 1320 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320124 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320124&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397365 384223398 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683383 CCc1cnc(s1)-c1cc(OC[C@@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1ccc(nn1)C(F)(F)F InChI=1S/C24H25F3N4O3S/c1-3-19-11-28-23(35-19)17-8-16(9-18(10-17)34-13-15-6-7-33-12-15)22(32)29-14(2)20-4-5-21(31-30-20)24(25,26)27/h4-5,8-11,14-15H,3,6-7,12-13H2,1-2H3,(H,29,32)/t14-,15-/m1/s1 PGRAVNCJCWWOPT-HUUCEWRRSA-N 320125 3-(5-ethyl-1,3- thiazol-2-yl)-5- [(3R)- tetrahydrofuran-3- ylmethoxy]-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3-yl] ethyl}benzamide::US10174016, Example 292::US10202369, Example 292 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320125 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320125&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397547 384223399 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683385 CC(C)c1cnc(s1)-c1cc(OC[C@@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1ccc(nn1)C(F)(F)F InChI=1S/C25H27F3N4O3S/c1-14(2)21-11-29-24(36-21)18-8-17(9-19(10-18)35-13-16-6-7-34-12-16)23(33)30-15(3)20-4-5-22(32-31-20)25(26,27)28/h4-5,8-11,14-16H,6-7,12-13H2,1-3H3,(H,30,33)/t15-,16-/m1/s1 ZWFOSAQPAKMJAC-HZPDHXFCSA-N 320126 3-[5-(propan-2-yl)- 1,3-thiazol-2-yl]-5- [(3R)- tetrahydrofuran-3- ylmethoxy]-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl}benzamide::US10174016, Example 293::US10202369, Example 301 P2X purinoceptor 3 Homo sapiens 63.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320126 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320126&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397373 384223400 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683387 CC(C)c1cnc(s1)-c1cc(O[C@@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1ccc(nn1)C(F)(F)F InChI=1S/C24H25F3N4O3S/c1-13(2)20-11-28-23(35-20)16-8-15(9-18(10-16)34-17-6-7-33-12-17)22(32)29-14(3)19-4-5-21(31-30-19)24(25,26)27/h4-5,8-11,13-14,17H,6-7,12H2,1-3H3,(H,29,32)/t14-,17-/m1/s1 ALCUBFBGIYQDIY-RHSMWYFYSA-N 320127 3-[5-(propan-2-yl)- 1,3-thiazol-2-yl]-5- [(3R)- tetrahydrofuran-3- yloxy]-N-{(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl}benzamide::US10174016, Example 294::US10202369, Example 294::US10472354, Example 294 P2X purinoceptor 3 Homo sapiens 101 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320127 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320127&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397844 384223401 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683389 C[C@@H](NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(s1)C1CCC1)c1ccc(nn1)C(F)(F)F InChI=1S/C25H25F3N4O3S/c1-14(20-5-6-22(32-31-20)25(26,27)28)30-23(33)16-9-17(11-19(10-16)35-18-7-8-34-13-18)24-29-12-21(36-24)15-3-2-4-15/h5-6,9-12,14-15,18H,2-4,7-8,13H2,1H3,(H,30,33)/t14-,18+/m1/s1 LCHSLMNVJPMESH-KDOFPFPSSA-N 320128 3-(5-cyclobutyl- 1,3-thiazol-2-yl)-5- [(3S)- tetrahydrofuran-3- yloxy]-N-{(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl}benzamide::US10174016, Example 295::US10202369, Example 295::US10472354, Example 295 P2X purinoceptor 3 Homo sapiens 55.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320128 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320128&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397441 384223402 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 682801 C[C@@H](NC(=O)c1cc(OCC2CC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C22H21F3N4O2S/c1-12-8-26-20(32-12)16-5-15(6-18(7-16)31-11-14-3-4-14)19(30)29-13(2)17-9-27-21(28-10-17)22(23,24)25/h5-10,13-14H,3-4,11H2,1-2H3,(H,29,30)/t13-/m1/s1 KPIHUQDIFGXEHA-CYBMUJFWSA-N 319834 3-(Cyclopropylmethoxy)-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 1::US10202369, Example 1::US10472354, Example 1 P2X purinoceptor 3 Homo sapiens 4.00 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319834 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319834&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397250 384223114 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 682803 Cc1cnc(s1)-c1cc(OCC2CC2)cc(c1)C(=O)NCc1ccc(C)nn1 InChI=1S/C21H22N4O2S/c1-13-3-6-18(25-24-13)11-22-20(26)16-7-17(21-23-10-14(2)28-21)9-19(8-16)27-12-15-4-5-15/h3,6-10,15H,4-5,11-12H2,1-2H3,(H,22,26) LHMIEJIRNSAGER-UHFFFAOYSA-N 319835 3-(Cyclopropylmethoxy)-N-[(6-methylpyridazin-3-yl)methyl]-5-(5-methyl-1,3-thiazol-2-yl)benzamide::US10174016, Example 2::US10202369, Example 2::US10472354, Example 2 P2X purinoceptor 3 Homo sapiens 19.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319835 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319835&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397260 384223115 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 682805 Cc1cnc(s1)-c1cc(OCC2CC2)cc(c1)C(=O)NCc1cnc(C)cn1 InChI=1S/C21H22N4O2S/c1-13-8-23-18(10-22-13)11-24-20(26)16-5-17(21-25-9-14(2)28-21)7-19(6-16)27-12-15-3-4-15/h5-10,15H,3-4,11-12H2,1-2H3,(H,24,26) SHCAJJQUYCQWRM-UHFFFAOYSA-N 319836 3-(Cyclopropylmethoxy)-N-[(5-methylpyrazin-2-yl)methyl]-5-(5-methyl-1,3-thiazol-2-yl)benzamide::US10174016, Example 3::US10202369, Example 3::US10472354, Example 3 P2X purinoceptor 3 Homo sapiens 26.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319836 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319836&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397194 384223116 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 682807 C[C@@H](NC(=O)c1cc(OCC2CC2)cc(c1)-c1ncc(C)s1)c1cnc(C)cn1 InChI=1S/C22H24N4O2S/c1-13-9-24-20(11-23-13)15(3)26-21(27)17-6-18(22-25-10-14(2)29-22)8-19(7-17)28-12-16-4-5-16/h6-11,15-16H,4-5,12H2,1-3H3,(H,26,27)/t15-/m1/s1 DYWYLXQLERQEEM-OAHLLOKOSA-N 319837 3-(Cyclopropylmethoxy)-N-[(1R)-1-(5-methylpyrazin-2-yl)ethyl]-5-(5-methyl-1,3-thiazol-2-yl)benzamide::US10174016, Example 4::US10202369, Example 4::US10472354, Example 4 P2X purinoceptor 3 Homo sapiens 9.00 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319837 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319837&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397428 384223117 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 682809 CC(NC(=O)c1cc(OCC2CC2)cc(c1)-c1ncc(C)s1)c1ncc(F)cc1Cl InChI=1S/C22H21ClFN3O2S/c1-12-9-26-22(30-12)16-5-15(6-18(7-16)29-11-14-3-4-14)21(28)27-13(2)20-19(23)8-17(24)10-25-20/h5-10,13-14H,3-4,11H2,1-2H3,(H,27,28) CGCJNRQFWMKWFU-UHFFFAOYSA-N 319838 N-[1-(3-Chloro-5-fluoropyridin-2-yl)ethyl]-3-(cyclopropylmethoxy)-5-(5-methyl-1,3-thiazol-2-yl)benzamide::US10174016, Example 5::US10202369, Example 5::US10472354, Example 5 P2X purinoceptor 3 Homo sapiens 16.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319838 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319838&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397491 384223118 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 682811 CC(NC(=O)c1cc(OCC2CC2)cc(c1)-c1ncc(C)s1)c1ncc(Cl)cc1F InChI=1S/C22H21ClFN3O2S/c1-12-9-26-22(30-12)16-5-15(6-18(7-16)29-11-14-3-4-14)21(28)27-13(2)20-19(24)8-17(23)10-25-20/h5-10,13-14H,3-4,11H2,1-2H3,(H,27,28) YIPUFXDTAKNGSX-UHFFFAOYSA-N 319839 N-[1-(5-Chloro-3-fluoropyridin-2-yl)ethyl]-3-(cyclopropylmethoxy)-5-(5-methyl-1,3-thiazol-2-yl)benzamide::US10174016, Example 6::US10202369, Example 6::US10472354, Example 6 P2X purinoceptor 3 Homo sapiens 4.00 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319839 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319839&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397488 384223119 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 682813 C[C@@H](NC(=O)c1cc(OCC2CC2)cc(c1)-c1ncc(C)s1)c1nnc(C)s1 InChI=1S/C20H22N4O2S2/c1-11-9-21-20(27-11)16-6-15(7-17(8-16)26-10-14-4-5-14)18(25)22-12(2)19-24-23-13(3)28-19/h6-9,12,14H,4-5,10H2,1-3H3,(H,22,25)/t12-/m1/s1 QOCVVHCSVZQPAR-GFCCVEGCSA-N 319840 3-(Cyclopropylmethoxy)-N-[(1R)-1-(5-methyl-1,3,4-thiadiazol-2-yl)ethyl]-5-(5-methyl-1,3-thiazol-2-yl)benzamide::US10174016, Example 7::US10202369, Example 7::US10472354, Example 7 P2X purinoceptor 3 Homo sapiens 8.00 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319840 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319840&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397154 384223120 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 682815 C[C@@H](NC(=O)c1cc(OCC2CC2)cc(c1)-c1ncc(C)s1)c1ccc(C)nn1 InChI=1S/C22H24N4O2S/c1-13-4-7-20(26-25-13)15(3)24-21(27)17-8-18(22-23-11-14(2)29-22)10-19(9-17)28-12-16-5-6-16/h4,7-11,15-16H,5-6,12H2,1-3H3,(H,24,27)/t15-/m1/s1 ZZPHBEIBURIANJ-OAHLLOKOSA-N 319841 3-(Cyclopropylmethoxy)-N-[(1R)-1-(6-methylpyridazin-3-yl)ethyl]-5-(5-methyl-1,3-thiazol-2-yl)benzamide::US10174016, Example 8::US10202369, Example 8::US10472354, Example 8 P2X purinoceptor 3 Homo sapiens 3.00 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319841 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319841&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397204 384223121 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 682817 C[C@@H](NC(=O)c1cc(OCC2CC2)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F InChI=1S/C22H21F3N4O2S/c1-12-10-26-21(32-12)16-7-15(8-17(9-16)31-11-14-3-4-14)20(30)27-13(2)18-5-6-19(29-28-18)22(23,24)25/h5-10,13-14H,3-4,11H2,1-2H3,(H,27,30)/t13-/m1/s1 FDEHTNMFMQMRCT-CYBMUJFWSA-N 319842 3-(Cyclopropylmethoxy)-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[6-(trifluoromethyl)pyridazin-3-yl]ethyl}benzamide::US10174016, Example 9::US10202369, Example 9::US10472354, Example 9 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319842 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319842&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397573 384223122 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 682819 C[C@@H](NC(=O)c1cc(OCC2CC2)cc(c1)-c1ncc(C)s1)c1cnc(C)nc1 InChI=1S/C22H24N4O2S/c1-13-9-25-22(29-13)18-6-17(7-20(8-18)28-12-16-4-5-16)21(27)26-14(2)19-10-23-15(3)24-11-19/h6-11,14,16H,4-5,12H2,1-3H3,(H,26,27)/t14-/m1/s1 HEHYSAYIHLPEGC-CQSZACIVSA-N 319843 3-(Cyclopropylmethoxy)-N-[(1R)-1-(2-methylpyrimidin-5-yl)ethyl]-5-(5-methyl-1,3-thiazol-2-yl)benzamide::US10174016, Example 10::US10202369, Example 10::US10472354, Example 10 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319843 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319843&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397702 384223123 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 682821 C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C22H21F3N4O3S/c1-12-8-26-20(33-12)15-5-14(6-18(7-15)32-17-3-4-31-11-17)19(30)29-13(2)16-9-27-21(28-10-16)22(23,24)25/h5-10,13,17H,3-4,11H2,1-2H3,(H,29,30)/t13-,17-/m1/s1 GTQPEQGDLVSFJO-CXAGYDPISA-N 319844 3-(5-Methyl-1,3-thiazol-2-yl)-5-[(3R)-tetrahydrofuran-3-yloxy]-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 11::US10202369, Example 11::US10472354, Example 291 P2X purinoceptor 3 Homo sapiens 8.00 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319844 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319844&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397587 384223124 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 682823 Cc1cnc(s1)-c1cc(O[C@@H]2CCOC2)cc(c1)C(=O)NCc1cnc(C)cn1 InChI=1S/C21H22N4O3S/c1-13-8-23-17(10-22-13)11-24-20(26)15-5-16(21-25-9-14(2)29-21)7-19(6-15)28-18-3-4-27-12-18/h5-10,18H,3-4,11-12H2,1-2H3,(H,24,26)/t18-/m1/s1 SKCSTCBULJTUPE-GOSISDBHSA-N 319845 N-[(5-methylpyrazin-2-yl)methyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(3R)-tetrahydrofuran-3-yloxy]benzamide::US10174016, Example 12::US10202369, Example 12 P2X purinoceptor 3 Homo sapiens 283 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319845 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319845&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397167 384223125 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 682825 CC(NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ncc(F)cc1Cl InChI=1S/C22H21ClFN3O3S/c1-12-9-26-22(31-12)15-5-14(6-18(7-15)30-17-3-4-29-11-17)21(28)27-13(2)20-19(23)8-16(24)10-25-20/h5-10,13,17H,3-4,11H2,1-2H3,(H,27,28)/t13?,17-/m1/s1 YETTUNLUNMEXML-LRHAYUFXSA-N 319846 N-[1-(3-chloro-5-fluoropyridin-2-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(3R)-tetrahydrofuran-3-yloxy]benzamide::US10174016, Example 13::US10202369, Example 13::US10472354, Example 13 P2X purinoceptor 3 Homo sapiens 21.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319846 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319846&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397669 384223126 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 682827 CC(NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ncc(Cl)cc1F InChI=1S/C22H21ClFN3O3S/c1-12-9-26-22(31-12)15-5-14(6-18(7-15)30-17-3-4-29-11-17)21(28)27-13(2)20-19(24)8-16(23)10-25-20/h5-10,13,17H,3-4,11H2,1-2H3,(H,27,28)/t13?,17-/m1/s1 DLODQDUFIVUCLQ-LRHAYUFXSA-N 319847 N-[1-(5-chloro-3-fluoropyridin-2-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(3R)-tetrahydrofuran-3-yloxy]benzamide::US10174016, Example 14::US10202369, Example 14::US10472354, Example 14 P2X purinoceptor 3 Homo sapiens 8.00 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319847 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319847&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397583 384223127 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 682829 C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ccc(Cl)cn1 InChI=1S/C22H22ClN3O3S/c1-13-10-25-22(30-13)16-7-15(8-19(9-16)29-18-5-6-28-12-18)21(27)26-14(2)20-4-3-17(23)11-24-20/h3-4,7-11,14,18H,5-6,12H2,1-2H3,(H,26,27)/t14-,18-/m1/s1 DURBVTDNVKUTOV-RDTXWAMCSA-N 319848 N-[(1R)-1-(5-chloropyridin-2-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(3R)-tetrahydrofuran-3-yloxy]benzamide::US10174016, Example 15::US10202369, Example 15::US10472354, Example 15 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319848 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319848&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397630 384223128 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 682831 C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1cnc(C)cn1 InChI=1S/C22H24N4O3S/c1-13-9-24-20(11-23-13)15(3)26-21(27)16-6-17(22-25-10-14(2)30-22)8-19(7-16)29-18-4-5-28-12-18/h6-11,15,18H,4-5,12H2,1-3H3,(H,26,27)/t15-,18-/m1/s1 GGLGXVJJVCGSBA-CRAIPNDOSA-N 319849 N-[(1R)-1-(5-methylpyrazin-2-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(3R)-tetrahydrofuran-3-yloxy]benzamide::US10174016, Example 16::US10202369, Example 16::US10472354, Example 16 P2X purinoceptor 3 Homo sapiens 38.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319849 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319849&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397267 384223129 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 682833 Cc1cnc(s1)-c1cc(O[C@@H]2CCOC2)cc(c1)C(=O)NCc1ccc(C)nn1 InChI=1S/C21H22N4O3S/c1-13-3-4-17(25-24-13)11-22-20(26)15-7-16(21-23-10-14(2)29-21)9-19(8-15)28-18-5-6-27-12-18/h3-4,7-10,18H,5-6,11-12H2,1-2H3,(H,22,26)/t18-/m1/s1 VKRRMZCTKMLCQJ-GOSISDBHSA-N 319850 N-[(6-methylpyridazin-3-yl)methyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(3R)-tetrahydrofuran-3-yloxy]benzamide::US10174016, Example 17::US10202369, Example 17::US10472354, Example 17 P2X purinoceptor 3 Homo sapiens 35.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319850 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319850&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397146 384223130 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 682835 C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ccc(C)nn1 InChI=1S/C22H24N4O3S/c1-13-4-5-20(26-25-13)15(3)24-21(27)16-8-17(22-23-11-14(2)30-22)10-19(9-16)29-18-6-7-28-12-18/h4-5,8-11,15,18H,6-7,12H2,1-3H3,(H,24,27)/t15-,18-/m1/s1 JJXMVDHMQZPOJY-CRAIPNDOSA-N 319851 N-[(1R)-1-(6-methylpyridazin-3-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(3R)-tetrahydrofuran-3-yloxy]benzamide::US10174016, Example 18::US10202369, Example 18::US10472354, Example 18 P2X purinoceptor 3 Homo sapiens 34.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319851 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319851&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397758 384223131 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 682837 C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F InChI=1S/C22H21F3N4O3S/c1-12-10-26-21(33-12)15-7-14(8-17(9-15)32-16-5-6-31-11-16)20(30)27-13(2)18-3-4-19(29-28-18)22(23,24)25/h3-4,7-10,13,16H,5-6,11H2,1-2H3,(H,27,30)/t13-,16-/m1/s1 DNHMMXLROIMBSA-CZUORRHYSA-N 319852 3-(5-Methyl-1,3-thiazol-2-yl)-5-[(3R)-tetrahydrofuran-3-yloxy]-N-{(1R)-1-[6-(trifluoromethyl)pyridazin-3-yl]ethyl}benzamide::US10174016, Example 19::US10202369, Example 19::US10472354, Example 19 P2X purinoceptor 3 Homo sapiens 19.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319852 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319852&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397747 384223132 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 682839 C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1nnc(C)s1 InChI=1S/C20H22N4O3S2/c1-11-9-21-20(28-11)15-6-14(7-17(8-15)27-16-4-5-26-10-16)18(25)22-12(2)19-24-23-13(3)29-19/h6-9,12,16H,4-5,10H2,1-3H3,(H,22,25)/t12-,16-/m1/s1 WVNVOAPVSAUSTP-MLGOLLRUSA-N 319853 N-[(1R)-1-(5-methyl-1,3,4-thiadiazol-2-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(3R)-tetrahydrofuran-3-yloxy]benzamide::US10174016, Example 20::US10202369, Example 20::US10472354, Example 20 P2X purinoceptor 3 Homo sapiens 35.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319853 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319853&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397835 384223133 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 682841 Cc1cnc(s1)-c1cc(O[C@@H]2CCOC2)cc(c1)C(=O)NCc1ccc(nn1)C(F)(F)F InChI=1S/C21H19F3N4O3S/c1-12-9-26-20(32-12)14-6-13(7-17(8-14)31-16-4-5-30-11-16)19(29)25-10-15-2-3-18(28-27-15)21(22,23)24/h2-3,6-9,16H,4-5,10-11H2,1H3,(H,25,29)/t16-/m1/s1 YZCYRJHHBOIVER-MRXNPFEDSA-N 319854 3-(5-Methyl-1,3-thiazol-2-yl)-5-[(3R)-tetrahydrofuran-3-yloxy]-N-{[6-(trifluoromethyl)pyridazin-3-yl]methyl}benzamide::US10174016, Example 21::US10202369, Example 21::US10472354, Example 21 P2X purinoceptor 3 Homo sapiens 71.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319854 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319854&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397575 384223134 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 682843 CC[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H23F3N4O3S/c1-3-19(16-10-28-22(29-11-16)23(24,25)26)30-20(31)14-6-15(21-27-9-13(2)34-21)8-18(7-14)33-17-4-5-32-12-17/h6-11,17,19H,3-5,12H2,1-2H3,(H,30,31)/t17-,19-/m1/s1 VUXDKUAYZMWTBM-IEBWSBKVSA-N 319855 3-(5-Methyl-1,3-thiazol-2-yl)-5-[(3R)-tetrahydrofuran-3-yloxy]-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]propyl}benzamide::US10174016, Example 22::US10202369, Example 22::US10472354, Example 22 P2X purinoceptor 3 Homo sapiens 132 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319855 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319855&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397246 384223135 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 682845 C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1cnc(C)nc1 InChI=1S/C22H24N4O3S/c1-13-9-25-22(30-13)17-6-16(7-20(8-17)29-19-4-5-28-12-19)21(27)26-14(2)18-10-23-15(3)24-11-18/h6-11,14,19H,4-5,12H2,1-3H3,(H,26,27)/t14-,19-/m1/s1 RHVHBKMOULQMJQ-AUUYWEPGSA-N 319856 N-[(1R)-1-(2-Methylpyrimidin-5-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(3R)-tetrahydrofuran-3-yloxy]benzamide::US10174016, Example 23::US10202369, Example 23 P2X purinoceptor 3 Homo sapiens 30.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319856 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319856&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397288 384223136 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 682847 C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ccc(C)nc1 InChI=1S/C23H25N3O3S/c1-14-4-5-17(12-24-14)16(3)26-22(27)18-8-19(23-25-11-15(2)30-23)10-21(9-18)29-20-6-7-28-13-20/h4-5,8-12,16,20H,6-7,13H2,1-3H3,(H,26,27)/t16-,20-/m1/s1 KGDPEGCMVCXNPY-OXQOHEQNSA-N 319857 N-[(1R)-1-(6-Methylpyridin-3-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(3R)-tetrahydrofuran-3-yloxy]benzamide::US10174016, Example 24::US10202369, Example 24 P2X purinoceptor 3 Homo sapiens 36.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319857 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319857&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397467 384223137 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 682849 C[C@@H](NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ccc(C)nn1 InChI=1S/C22H24N4O3S/c1-13-4-5-20(26-25-13)15(3)24-21(27)16-8-17(22-23-11-14(2)30-22)10-19(9-16)29-18-6-7-28-12-18/h4-5,8-11,15,18H,6-7,12H2,1-3H3,(H,24,27)/t15-,18+/m1/s1 JJXMVDHMQZPOJY-QAPCUYQASA-N 319858 N-[(1R)-1-(6-Methylpyridazin-3-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(3S)-tetrahydrofuran-3-yloxy]benzamide::US10174016, Example 25::US10202369, Example 25::US10472354, Example 25 P2X purinoceptor 3 Homo sapiens 39.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319858 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319858&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397569 384223138 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 682851 C[C@@H](NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C22H21F3N4O3S/c1-12-8-26-20(33-12)15-5-14(6-18(7-15)32-17-3-4-31-11-17)19(30)29-13(2)16-9-27-21(28-10-16)22(23,24)25/h5-10,13,17H,3-4,11H2,1-2H3,(H,29,30)/t13-,17+/m1/s1 GTQPEQGDLVSFJO-DYVFJYSZSA-N 319859 3-(5-Methyl-1,3-thiazol-2-yl)-5-[(3S)-tetrahydrofuran-3-yloxy]-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 26::US10202369, Example 26::US10472354, Example 26 P2X purinoceptor 3 Homo sapiens 8.00 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319859 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319859&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397418 384223139 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 682853 C[C@@H](NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ccc(Cl)cn1 InChI=1S/C22H22ClN3O3S/c1-13-10-25-22(30-13)16-7-15(8-19(9-16)29-18-5-6-28-12-18)21(27)26-14(2)20-4-3-17(23)11-24-20/h3-4,7-11,14,18H,5-6,12H2,1-2H3,(H,26,27)/t14-,18+/m1/s1 DURBVTDNVKUTOV-KDOFPFPSSA-N 319860 N-[(1R)-1-(5-Chloropyridin-2-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(3S)-tetrahydrofuran-3-yloxy]benzamide::US10174016, Example 27::US10202369, Example 27::US10472354, Example 27 P2X purinoceptor 3 Homo sapiens 25.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319860 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319860&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397158 384223140 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 682855 C[C@@H](NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ccc(C)cn1 InChI=1S/C23H25N3O3S/c1-14-4-5-21(24-11-14)16(3)26-22(27)17-8-18(23-25-12-15(2)30-23)10-20(9-17)29-19-6-7-28-13-19/h4-5,8-12,16,19H,6-7,13H2,1-3H3,(H,26,27)/t16-,19+/m1/s1 CFTQNAYGOFQJGD-APWZRJJASA-N 319861 N-[(1R)-1-(5-Methylpyridin-2-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(3S)-tetrahydrofuran-3-yloxy]benzamide::US10174016, Example 28::US10202369, Example 28::US10472354, Example 28 P2X purinoceptor 3 Homo sapiens 48.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319861 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319861&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397224 384223141 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 682857 C[C@@H](NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1cnc(Cl)cn1 InChI=1S/C21H21ClN4O3S/c1-12-8-25-21(30-12)15-5-14(6-17(7-15)29-16-3-4-28-11-16)20(27)26-13(2)18-9-24-19(22)10-23-18/h5-10,13,16H,3-4,11H2,1-2H3,(H,26,27)/t13-,16+/m1/s1 WDGLIKLPMFVJPN-CJNGLKHVSA-N 346042 N-[(1R)-1-(5-Methylpyrazin-2-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(3S)-tetrahydrofuran-3-yloxy]benzamide::US10202369, Example 29 P2X purinoceptor 3 Homo sapiens 79.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=346042 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=346042&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134391353 385452094 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 682859 C[C@@H](NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ccc(C)nc1 InChI=1S/C23H25N3O3S/c1-14-4-5-17(12-24-14)16(3)26-22(27)18-8-19(23-25-11-15(2)30-23)10-21(9-18)29-20-6-7-28-13-20/h4-5,8-12,16,20H,6-7,13H2,1-3H3,(H,26,27)/t16-,20+/m1/s1 KGDPEGCMVCXNPY-UZLBHIALSA-N 319863 N-[(1R)-1-(6- Methylpyridin- 3-yl)ethyl]-3- (5-methyl-1,3- thiazol-2-yl)-5- [(3S)- tetrahydrofuran- 3-yloxy] benzamide::US10174016, Example 30::US10202369, Example 30::US10472354, Example 30 P2X purinoceptor 3 Homo sapiens 38.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319863 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319863&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397828 384223143 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683391 CCc1cnc(s1)-c1cc(OC[C@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1ccc(nn1)C(F)(F)F InChI=1S/C24H25F3N4O3S/c1-3-19-11-28-23(35-19)17-8-16(9-18(10-17)34-13-15-6-7-33-12-15)22(32)29-14(2)20-4-5-21(31-30-20)24(25,26)27/h4-5,8-11,14-15H,3,6-7,12-13H2,1-2H3,(H,29,32)/t14-,15+/m1/s1 PGRAVNCJCWWOPT-CABCVRRESA-N 320129 3-(5-ethyl-1,3- thiazol-2-yl)-5- [(3S)- tetrahydrofuran-3- ylmethoxy]-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl}benzamide::US10174016, Example 296::US10202369, Example 296::US10472354, Example 296 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320129 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320129&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397487 384223403 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683393 C[C@@H](NC(=O)c1cc(OC[C@@H]2CCOC2)cc(c1)-c1ncc(s1)C1CCC1)c1ccc(nn1)C(F)(F)F InChI=1S/C26H27F3N4O3S/c1-15(21-5-6-23(33-32-21)26(27,28)29)31-24(34)18-9-19(25-30-12-22(37-25)17-3-2-4-17)11-20(10-18)36-14-16-7-8-35-13-16/h5-6,9-12,15-17H,2-4,7-8,13-14H2,1H3,(H,31,34)/t15-,16-/m1/s1 BURFLVDKSSJHQL-HZPDHXFCSA-N 320130 3-(5-cyclobutyl- 1,3-thiazol-2-yl)-5- [(3R)- tetrahydrofuran-3- ylmethoxy]-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl}benzamide::US10174016, Example 297::US10202369, Example 300::US10472354, Example 297 P2X purinoceptor 3 Homo sapiens 56.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320130 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320130&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397174 384223404 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683395 CC(C)c1cnc(s1)-c1cc(OC[C@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1ccc(nn1)C(F)(F)F InChI=1S/C25H27F3N4O3S/c1-14(2)21-11-29-24(36-21)18-8-17(9-19(10-18)35-13-16-6-7-34-12-16)23(33)30-15(3)20-4-5-22(32-31-20)25(26,27)28/h4-5,8-11,14-16H,6-7,12-13H2,1-3H3,(H,30,33)/t15-,16+/m1/s1 ZWFOSAQPAKMJAC-CVEARBPZSA-N 320131 3-[5-(propan-2-yl)- 1,3-thiazol-2-yl]-5- [(3S)- tetrahydrofuran-3- ylmethoxy]-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl}benzamide::US10174016, Example 298::US10202369, Example 299::US10472354, Example 298 P2X purinoceptor 3 Homo sapiens 62.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320131 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320131&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397407 384223405 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683397 CC(C)c1cnc(s1)-c1cc(OC[C@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1ccc(nn1)C(F)(F)F InChI=1S/C25H27F3N4O3S/c1-14(2)21-11-29-24(36-21)18-8-17(9-19(10-18)35-13-16-6-7-34-12-16)23(33)30-15(3)20-4-5-22(32-31-20)25(26,27)28/h4-5,8-11,14-16H,6-7,12-13H2,1-3H3,(H,30,33)/t15-,16+/m1/s1 ZWFOSAQPAKMJAC-CVEARBPZSA-N 320131 3-[5-(propan-2-yl)- 1,3-thiazol-2-yl]-5- [(3S)- tetrahydrofuran-3- ylmethoxy]-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl}benzamide::US10174016, Example 298::US10202369, Example 299::US10472354, Example 298 P2X purinoceptor 3 Homo sapiens 37.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320131 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320131&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397407 384223405 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683399 C[C@@H](NC(=O)c1cc(OC[C@@H]2CCOC2)cc(c1)-c1ncc(s1)C1CCC1)c1ccc(nn1)C(F)(F)F InChI=1S/C26H27F3N4O3S/c1-15(21-5-6-23(33-32-21)26(27,28)29)31-24(34)18-9-19(25-30-12-22(37-25)17-3-2-4-17)11-20(10-18)36-14-16-7-8-35-13-16/h5-6,9-12,15-17H,2-4,7-8,13-14H2,1H3,(H,31,34)/t15-,16-/m1/s1 BURFLVDKSSJHQL-HZPDHXFCSA-N 320130 3-(5-cyclobutyl- 1,3-thiazol-2-yl)-5- [(3R)- tetrahydrofuran-3- ylmethoxy]-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl}benzamide::US10174016, Example 297::US10202369, Example 300::US10472354, Example 297 P2X purinoceptor 3 Homo sapiens 78.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320130 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320130&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397174 384223404 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683401 CC(C)c1cnc(s1)-c1cc(OC[C@@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1ccc(nn1)C(F)(F)F InChI=1S/C25H27F3N4O3S/c1-14(2)21-11-29-24(36-21)18-8-17(9-19(10-18)35-13-16-6-7-34-12-16)23(33)30-15(3)20-4-5-22(32-31-20)25(26,27)28/h4-5,8-11,14-16H,6-7,12-13H2,1-3H3,(H,30,33)/t15-,16-/m1/s1 ZWFOSAQPAKMJAC-HZPDHXFCSA-N 320126 3-[5-(propan-2-yl)- 1,3-thiazol-2-yl]-5- [(3R)- tetrahydrofuran-3- ylmethoxy]-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl}benzamide::US10174016, Example 293::US10202369, Example 301 P2X purinoceptor 3 Homo sapiens 91.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320126 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320126&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397373 384223400 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683403 CCc1cnc(s1)-c1cc(OC[C@@H]2CCCO2)cc(c1)C(=O)N[C@H](C)c1ccc(nn1)C(F)(F)F InChI=1S/C24H25F3N4O3S/c1-3-19-12-28-23(35-19)16-9-15(10-18(11-16)34-13-17-5-4-8-33-17)22(32)29-14(2)20-6-7-21(31-30-20)24(25,26)27/h6-7,9-12,14,17H,3-5,8,13H2,1-2H3,(H,29,32)/t14-,17+/m1/s1 JBKILHBMFZDIIA-PBHICJAKSA-N 320135 3-(5-ethyl-1,3- thiazol-2-yl)-5- [(2S)- tetrahydrofuran-2- ylmethoxy]-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl}benzamide::US10174016, Example 302::US10202369, Example 302::US10472354, Example 302 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320135 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320135&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397753 384223409 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683405 C[C@@H](NC(=O)c1cc(OC2CCN(CC(F)(F)F)CC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C25H25F6N5O2S/c1-14-10-32-22(39-14)17-7-16(21(37)35-15(2)18-11-33-23(34-12-18)25(29,30)31)8-20(9-17)38-19-3-5-36(6-4-19)13-24(26,27)28/h7-12,15,19H,3-6,13H2,1-2H3,(H,35,37)/t15-/m1/s1 HEBACSHOFHMYBR-OAHLLOKOSA-N 320136 3-(5-methyl-1,3- thiazol-2-yl)-5-{[1- (2,2,2- trifluoroethyl) piperidin-4-yl]oxy}- N-{(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 303::US10202369, Example 310::US10472354, Example 303 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320136 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320136&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397490 384223410 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683407 C[C@@H](NC(=O)c1cc(OC2CCN(CC(F)F)CC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C25H26F5N5O2S/c1-14-10-31-23(38-14)17-7-16(8-20(9-17)37-19-3-5-35(6-4-19)13-21(26)27)22(36)34-15(2)18-11-32-24(33-12-18)25(28,29)30/h7-12,15,19,21H,3-6,13H2,1-2H3,(H,34,36)/t15-/m1/s1 LOLIYPRJHUXCPO-OAHLLOKOSA-N 320137 3-{[1-(2,2- difluoroethyl) piperidin-4-yl]oxy}- 5-(5-methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoroethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 304::US10202369, Example 308::US10472354, Example 304 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320137 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320137&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397386 384223411 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683409 C[C@@H](NC(=O)c1cc(OC2CCN(CC(F)F)CC2)cc(c1)-c1ncc(C)s1)c1ccc(C)nn1 InChI=1S/C25H29F2N5O2S/c1-15-4-5-22(31-30-15)17(3)29-24(33)18-10-19(25-28-13-16(2)35-25)12-21(11-18)34-20-6-8-32(9-7-20)14-23(26)27/h4-5,10-13,17,20,23H,6-9,14H2,1-3H3,(H,29,33)/t17-/m1/s1 BZVNHOBJGKGQCM-QGZVFWFLSA-N 320138 3-{[1-(2,2- difluoroethyl) piperidin-4-yl]oxy}-N- [(1R)-1-(6- methylpyridazin-3- yl)ethyl]-5-(5- methyl-1,3- thiazol-2-yl) benzamide::US10174016, Example 305::US10202369, Example 305::US10472354, Example 305 P2X purinoceptor 3 Homo sapiens 9.00 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320138 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320138&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397226 384223412 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683411 C[C@@H](NC(=O)c1cc(OC2CCN(CC(F)F)CC2)cc(c1)-c1ncc(C)s1)c1cnc(C)cn1 InChI=1S/C25H29F2N5O2S/c1-15-11-29-22(13-28-15)17(3)31-24(33)18-8-19(25-30-12-16(2)35-25)10-21(9-18)34-20-4-6-32(7-5-20)14-23(26)27/h8-13,17,20,23H,4-7,14H2,1-3H3,(H,31,33)/t17-/m1/s1 OVUBAZICSOPILB-QGZVFWFLSA-N 320139 3-{[1-(2,2- difluoroethyl) piperidin-4-yl]oxy}-N- [(1R)-1-(5- methylpyrazin-2- yl)ethyl]-5-(5- methyl-1,3- thiazol-2-yl) benzamide::US10174016, Example 306::US10202369, Example 306::US10472354, Example 306 P2X purinoceptor 3 Homo sapiens 42.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320139 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320139&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397132 384223413 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683413 Cc1cnc(s1)-c1cc(OC2CCN(CC(F)F)CC2)cc(c1)C(=O)NCc1ccc(C)nn1 InChI=1S/C24H27F2N5O2S/c1-15-3-4-19(30-29-15)13-27-23(32)17-9-18(24-28-12-16(2)34-24)11-21(10-17)33-20-5-7-31(8-6-20)14-22(25)26/h3-4,9-12,20,22H,5-8,13-14H2,1-2H3,(H,27,32) AGOFJROZQVOSRF-UHFFFAOYSA-N 320140 3-{[1-(2,2- difluoroethyl)piperidin- 4-yl]oxy}-N- [(6-methylpyridazin- 3-yl)methyl]-5-(5- methyl-1,3-thiazol-2- yl)benzamide::US10174016, Example 307::US10202369, Example 307::US10472354, Example 307 P2X purinoceptor 3 Homo sapiens 16.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320140 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320140&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397369 384223414 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683415 C[C@@H](NC(=O)c1cc(OC2CCN(CC(F)F)CC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C25H26F5N5O2S/c1-14-10-31-23(38-14)17-7-16(8-20(9-17)37-19-3-5-35(6-4-19)13-21(26)27)22(36)34-15(2)18-11-32-24(33-12-18)25(28,29)30/h7-12,15,19,21H,3-6,13H2,1-2H3,(H,34,36)/t15-/m1/s1 LOLIYPRJHUXCPO-OAHLLOKOSA-N 320137 3-{[1-(2,2- difluoroethyl) piperidin-4-yl]oxy}- 5-(5-methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoroethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 304::US10202369, Example 308::US10472354, Example 304 P2X purinoceptor 3 Homo sapiens 153 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320137 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320137&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397386 384223411 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683417 C[C@@H](NC(=O)c1cc(OC2CCN(CC(F)F)CC2)cc(c1)-c1ncc(C)s1)c1cnc(C)nc1 InChI=1S/C25H29F2N5O2S/c1-15-11-30-25(35-15)19-8-18(24(33)31-16(2)20-12-28-17(3)29-13-20)9-22(10-19)34-21-4-6-32(7-5-21)14-23(26)27/h8-13,16,21,23H,4-7,14H2,1-3H3,(H,31,33)/t16-/m1/s1 XIVLMPYTLPVWPV-MRXNPFEDSA-N 320142 3-{[1-(2,2- difluoroethyl)piperidin- 4-yl]oxy}-N- [(1R)-1-(2- methylpyrimidin- 5-yl)ethyl]-5-(5- methyl-1,3-thiazol-2- yl)benzamide::US10174016, Example 309::US10202369, Example 309::US10472354, Example 309 P2X purinoceptor 3 Homo sapiens 8.00 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320142 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320142&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397638 384223416 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683419 C[C@@H](NC(=O)c1cc(OC2CCN(CC(F)(F)F)CC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C25H25F6N5O2S/c1-14-10-32-22(39-14)17-7-16(21(37)35-15(2)18-11-33-23(34-12-18)25(29,30)31)8-20(9-17)38-19-3-5-36(6-4-19)13-24(26,27)28/h7-12,15,19H,3-6,13H2,1-2H3,(H,35,37)/t15-/m1/s1 HEBACSHOFHMYBR-OAHLLOKOSA-N 320136 3-(5-methyl-1,3- thiazol-2-yl)-5-{[1- (2,2,2- trifluoroethyl) piperidin-4-yl]oxy}- N-{(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 303::US10202369, Example 310::US10472354, Example 303 P2X purinoceptor 3 Homo sapiens 116 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320136 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320136&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397490 384223410 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683421 C[C@@H](NC(=O)c1cc(OC2CCN(CC(F)(F)F)CC2)cc(c1)-c1ncc(C)s1)c1ccc(C)nn1 InChI=1S/C25H28F3N5O2S/c1-15-4-5-22(32-31-15)17(3)30-23(34)18-10-19(24-29-13-16(2)36-24)12-21(11-18)35-20-6-8-33(9-7-20)14-25(26,27)28/h4-5,10-13,17,20H,6-9,14H2,1-3H3,(H,30,34)/t17-/m1/s1 PEAPNGOBIXQGEJ-QGZVFWFLSA-N 320144 N-[(1R)-1-(6- methylpyridazin-3- yl)ethyl]-3-(5- methyl-1,3- thiazol-2-yl)-5-{[1- (2,2,2- trifluoroethyl) piperidin-4-yl]oxy} benzamide::US10174016, Example 311::US10202369, Example 311::US10472354, Example 314 P2X purinoceptor 3 Homo sapiens 8.00 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320144 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320144&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397300 384223418 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683423 C[C@@H](NC(=O)c1cc(OC2CCN(CC(F)(F)F)CC2)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F InChI=1S/C25H25F6N5O2S/c1-14-12-32-23(39-14)17-9-16(22(37)33-15(2)20-3-4-21(35-34-20)25(29,30)31)10-19(11-17)38-18-5-7-36(8-6-18)13-24(26,27)28/h3-4,9-12,15,18H,5-8,13H2,1-2H3,(H,33,37)/t15-/m1/s1 AZRJUXHXOIFVSM-OAHLLOKOSA-N 320145 3-(5-methyl-1,3- thiazol-2-yl)-5-{[1- (2,2,2- trifluoroethyl) piperidin-4-yl]oxy}-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl}benzamide::US10174016, Example 312::US10202369, Example 312::US10472354, Example 312 P2X purinoceptor 3 Homo sapiens 9.00 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320145 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320145&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397364 384223419 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683425 C[C@@H](NC(=O)c1cc(OC2CCN(CC(F)(F)F)CC2)cc(c1)-c1ncc(C)s1)c1cnc(C)cn1 InChI=1S/C25H28F3N5O2S/c1-15-11-30-22(13-29-15)17(3)32-23(34)18-8-19(24-31-12-16(2)36-24)10-21(9-18)35-20-4-6-33(7-5-20)14-25(26,27)28/h8-13,17,20H,4-7,14H2,1-3H3,(H,32,34)/t17-/m1/s1 VOYLEHBGAUIAGN-QGZVFWFLSA-N 320146 N-[(1R)-1-(5- methylpyrazin-2- yl)ethyl]-3-(5- methyl-1,3- thiazol-2-yl)-5-{[1- (2,2,2- trifluoroethyl) piperidin-4- yl]oxy}benzamide::US10174016, Example 313::US10202369, Example 313::US10472354, Example 313 P2X purinoceptor 3 Homo sapiens 11.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320146 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320146&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397805 384223420 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683427 Cc1cnc(s1)-c1cc(OC2CCN(CC(F)(F)F)CC2)cc(c1)C(=O)NCc1ccc(C)nn1 InChI=1S/C24H26F3N5O2S/c1-15-3-4-19(31-30-15)13-28-22(33)17-9-18(23-29-12-16(2)35-23)11-21(10-17)34-20-5-7-32(8-6-20)14-24(25,26)27/h3-4,9-12,20H,5-8,13-14H2,1-2H3,(H,28,33) OUYWWDOEFAUISF-UHFFFAOYSA-N 320147 N-[(6- methylpyridazin-3- yl)methyl]-3-(5- methyl-1,3- thiazol-2-yl)-5-{[1- (2,2,2- trifluoroethyl) piperidin-4-yl]oxy} benzamide::US10174016, Example 314::US10202369, Example 314 P2X purinoceptor 3 Homo sapiens 8.00 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320147 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320147&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397402 384223421 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683429 C[C@@H](NC(=O)c1cc(OC2CCN(CC(F)(F)F)CC2)cc(c1)-c1ncc(C)s1)c1cnc(C)nc1 InChI=1S/C25H28F3N5O2S/c1-15-11-31-24(36-15)19-8-18(23(34)32-16(2)20-12-29-17(3)30-13-20)9-22(10-19)35-21-4-6-33(7-5-21)14-25(26,27)28/h8-13,16,21H,4-7,14H2,1-3H3,(H,32,34)/t16-/m1/s1 CJWKMIQNKLHRQL-MRXNPFEDSA-N 320148 N-[(1R)-1-(2- methylpyrimidin- 5-yl)ethyl]-3-(5- methyl-1,3- thiazol-2-yl)-5-{[1- (2,2,2- trifluoroethyl) piperidin-4-yl]oxy} benzamide::US10174016, Example 315::US10202369, Example 315::US10472354, Example 315 P2X purinoceptor 3 Homo sapiens 8.00 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320148 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320148&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397608 384223422 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683431 C[C@@H](NC(=O)c1cc(OC[C@H]2CCOC2)cc(c1)C1NC=C(Cl)S1)c1ccc(C)nn1 InChI=1S/C22H25ClN4O3S/c1-13-3-4-19(27-26-13)14(2)25-21(28)16-7-17(22-24-10-20(23)31-22)9-18(8-16)30-12-15-5-6-29-11-15/h3-4,7-10,14-15,22,24H,5-6,11-12H2,1-2H3,(H,25,28)/t14-,15+,22?/m1/s1 QWUQFFBGJOHYNC-VBIGTEDFSA-N 346329 3-(5-chloro-1,3- thiazol-2-yl)-N- [(1R)-1-(6- methyl- pyridazin-3- yl)ethyl]- 5-[(3S)- tetrahydrofuran- 3-ylmethoxy] benzamide::US10202369, Example 316 P2X purinoceptor 3 Homo sapiens 21.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=346329 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=346329&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134391359 385452375 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683433 C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(Cl)s1)c1ccc(C)nn1 InChI=1S/C21H21ClN4O3S/c1-12-3-4-18(26-25-12)13(2)24-20(27)14-7-15(21-23-10-19(22)30-21)9-17(8-14)29-16-5-6-28-11-16/h3-4,7-10,13,16H,5-6,11H2,1-2H3,(H,24,27)/t13-,16-/m1/s1 GKNCXHRLEQHNKW-CZUORRHYSA-N 320150 3-(5-chloro-1,3- thiazol-2-yl)-N- [(1R)-1-(6- methylpyridazin-3- yl)ethyl]-5-[(3R)- tetrahydrofuran-3- yloxy]benzamide::US10174016, Example 317::US10202369, Example 317::US10472354, Example 317 P2X purinoceptor 3 Homo sapiens 45.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320150 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320150&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397433 384223424 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683435 C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(Cl)s1)c1ccc(nn1)C(F)(F)F InChI=1S/C21H18ClF3N4O3S/c1-11(16-2-3-17(29-28-16)21(23,24)25)27-19(30)12-6-13(20-26-9-18(22)33-20)8-15(7-12)32-14-4-5-31-10-14/h2-3,6-9,11,14H,4-5,10H2,1H3,(H,27,30)/t11-,14-/m1/s1 WZQSUVWYIQCPQJ-BXUZGUMPSA-N 320151 3-(5-chloro-1,3- thiazol-2-yl)-5- [(3R)- tetrahydrofuran-3- yloxy]-N-{(1R)-1- [6- (trifluoromethyl) pyridazin-3- yl]ethyl}benzamide::US10174016, Example 318::US10202369, Example 318::US10472354, Example 318 P2X purinoceptor 3 Homo sapiens 32.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320151 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320151&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397509 384223425 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683437 C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(Cl)s1)c1cnc(C)cn1 InChI=1S/C21H21ClN4O3S/c1-12-8-24-18(9-23-12)13(2)26-20(27)14-5-15(21-25-10-19(22)30-21)7-17(6-14)29-16-3-4-28-11-16/h5-10,13,16H,3-4,11H2,1-2H3,(H,26,27)/t13-,16-/m1/s1 NPEHDEPJRQIOFY-CZUORRHYSA-N 320152 3-(5-chloro-1,3- thiazol-2-yl)-N- [(1R)-1-(5- methylpyrazin-2- yl)ethyl]-5-[(3R)- tetrahydrofuran-3- yloxy]benzamide::US10174016, Example 319::US10202369, Example 319::US10472354, Example 319 P2X purinoceptor 3 Homo sapiens 76.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320152 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320152&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397412 384223426 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683439 C[C@@H](NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(Cl)s1)c1ccc(nn1)C(F)(F)F InChI=1S/C21H18ClF3N4O3S/c1-11(16-2-3-17(29-28-16)21(23,24)25)27-19(30)12-6-13(20-26-9-18(22)33-20)8-15(7-12)32-14-4-5-31-10-14/h2-3,6-9,11,14H,4-5,10H2,1H3,(H,27,30)/t11-,14+/m1/s1 WZQSUVWYIQCPQJ-RISCZKNCSA-N 320153 3-(5-chloro-1,3- thiazol-2-yl)-5- [(3S)- tetrahydrofuran-3- yloxy]-N-{(1R)-1- [6- (trifluoromethyl) pyridazin-3- yl]ethyl}benzamide::US10174016, Example 320::US10202369, Example 320::US10472354, Example 320 P2X purinoceptor 3 Homo sapiens 33.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320153 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320153&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397157 384223427 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683441 C[C@@H](NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(Cl)s1)c1cnc(C)cn1 InChI=1S/C21H21ClN4O3S/c1-12-8-24-18(9-23-12)13(2)26-20(27)14-5-15(21-25-10-19(22)30-21)7-17(6-14)29-16-3-4-28-11-16/h5-10,13,16H,3-4,11H2,1-2H3,(H,26,27)/t13-,16+/m1/s1 NPEHDEPJRQIOFY-CJNGLKHVSA-N 320154 3-(5-chloro-1,3- thiazol-2-yl)-N- [(1R)-1-(5- methylpyrazin-2- yl)ethyl]-5-[(3S)- tetrahydrofuran-3- yloxy]benzamide::US10174016, Example 321::US10202369, Example 321::US10472354, Example 321 P2X purinoceptor 3 Homo sapiens 120 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320154 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320154&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397403 384223428 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683443 C[C@@H](NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(Cl)s1)c1ccc(C)nn1 InChI=1S/C21H21ClN4O3S/c1-12-3-4-18(26-25-12)13(2)24-20(27)14-7-15(21-23-10-19(22)30-21)9-17(8-14)29-16-5-6-28-11-16/h3-4,7-10,13,16H,5-6,11H2,1-2H3,(H,24,27)/t13-,16+/m1/s1 GKNCXHRLEQHNKW-CJNGLKHVSA-N 320155 3-(5-chloro-1,3- thiazol-2-yl)-N- [(1R)-1-(6- methylpyridazin-3- yl)ethyl]-5-[(3S)- tetrahydrofuran-3- yloxy]benzamide::US10174016, Example 322::US10202369, Example 322::US10472354, Example 322 P2X purinoceptor 3 Homo sapiens 49.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320155 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320155&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397765 384223429 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683445 C[C@@H](NC(=O)c1cc(OC[C@H]2CCOC2)cc(c1)-c1ncc(Cl)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C22H20ClF3N4O3S/c1-12(16-7-28-21(29-8-16)22(24,25)26)30-19(31)14-4-15(20-27-9-18(23)34-20)6-17(5-14)33-11-13-2-3-32-10-13/h4-9,12-13H,2-3,10-11H2,1H3,(H,30,31)/t12-,13+/m1/s1 SQNSHDCXZQFUAQ-OLZOCXBDSA-N 320156 3-(5-chloro-1,3- thiazol-2-yl)-5- [(3S)- tetrahydrofuran-3- ylmethoxy]-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 323::US10202369, Example 323::US10472354, Example 323 P2X purinoceptor 3 Homo sapiens 25.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320156 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320156&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397761 384223430 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683447 C[C@@H](NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(Cl)s1)c1cnc(C)cn1 InChI=1S/C22H23ClN4O3S/c1-13-10-25-19(11-24-13)14(2)27-21(28)15-7-16(22-26-12-20(23)31-22)9-18(8-15)30-17-3-5-29-6-4-17/h7-12,14,17H,3-6H2,1-2H3,(H,27,28)/t14-/m1/s1 LHUVAVZJRUVQTK-CQSZACIVSA-N 320157 3-(5-chloro-1,3- thiazol-2-yl)-N- [(1R)-1-(5- methylpyrazin-2- yl)ethyl]-5- (tetrahydro-2H- pyran-4- yloxy)benzamide::US10174016, Example 324::US10202369, Example 324::US10472354, Example 324 P2X purinoceptor 3 Homo sapiens 46.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320157 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320157&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397374 384223431 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683449 C[C@@H](NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(Cl)s1)c1ccc(C)nn1 InChI=1S/C22H23ClN4O3S/c1-13-3-4-19(27-26-13)14(2)25-21(28)15-9-16(22-24-12-20(23)31-22)11-18(10-15)30-17-5-7-29-8-6-17/h3-4,9-12,14,17H,5-8H2,1-2H3,(H,25,28)/t14-/m1/s1 WDEIMZWFSWTCLU-CQSZACIVSA-N 320158 3-(5-chloro-1,3- thiazol-2-yl)-N- [(1R)-1-(6- methylpyridazin-3- yl)ethyl]-5- (tetrahydro-2H- pyran-4- yloxy)benzamide::US10174016, Example 325::US10202369, Example 325::US10472354, Example 325 P2X purinoceptor 3 Homo sapiens 26.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320158 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320158&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397325 384223432 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683451 C[C@@H](NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(Cl)s1)c1ccc(nn1)C(F)(F)F InChI=1S/C22H20ClF3N4O3S/c1-12(17-2-3-18(30-29-17)22(24,25)26)28-20(31)13-8-14(21-27-11-19(23)34-21)10-16(9-13)33-15-4-6-32-7-5-15/h2-3,8-12,15H,4-7H2,1H3,(H,28,31)/t12-/m1/s1 LBZPSHGDCXIMLR-GFCCVEGCSA-N 320159 3-(5-chloro-1,3- thiazol-2-yl)-5- (tetrahydro-2H- pyran-4-yloxy)-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl}benzamide::US10174016, Example 326::US10202369, Example 326::US10472354, Example 326 P2X purinoceptor 3 Homo sapiens 21.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320159 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320159&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397539 384223433 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683453 C[C@@H](NC(=O)c1cc(OCC2(C)COC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H23F3N4O3S/c1-13-7-27-20(34-13)16-4-15(5-18(6-16)33-12-22(3)10-32-11-22)19(31)30-14(2)17-8-28-21(29-9-17)23(24,25)26/h4-9,14H,10-12H2,1-3H3,(H,30,31)/t14-/m1/s1 JVDZTZBJXQINIP-CQSZACIVSA-N 320160 3-[(3- methyloxetan-3- yl)methoxy]-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 327::US10202369, Example 327::US10472354, Example 327 P2X purinoceptor 3 Homo sapiens 10.00 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320160 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320160&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397492 384223434 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683455 C[C@@H](NC(=O)c1cc(OCC(C)(C)C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H25F3N4O2S/c1-13-9-27-20(33-13)16-6-15(7-18(8-16)32-12-22(3,4)5)19(31)30-14(2)17-10-28-21(29-11-17)23(24,25)26/h6-11,14H,12H2,1-5H3,(H,30,31)/t14-/m1/s1 CYTLZVKLWUDWCI-CQSZACIVSA-N 322517 3-(2-hydroxy-2- methylpropoxy)-5- (5-methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5-yl] ethyl}benzamide::US10183937, Example 328::US10202369, Example 328 P2X purinoceptor 3 Homo sapiens 12.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322517 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322517&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134338448 384225579 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 682861 Cc1cnc(s1)-c1cc(OCC#C)cc(c1)C(=O)NCc1ccc(C)nn1 InChI=1S/C20H18N4O2S/c1-4-7-26-18-9-15(8-16(10-18)20-22-11-14(3)27-20)19(25)21-12-17-6-5-13(2)23-24-17/h1,5-6,8-11H,7,12H2,2-3H3,(H,21,25) JDOBHPRLWOBCFP-UHFFFAOYSA-N 319864 N-[(6- Methylpyridazin- 3-yl)methyl]-3- (5-methyl-1,3- thiazol-2-yl)-5- (prop-2-yn-1- yloxy) benzamide::US10174016, Example 31::US10202369, Example 31::US10472354, Example 31 P2X purinoceptor 3 Homo sapiens 173 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319864 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319864&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397457 384223144 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 682863 Cc1cnc(s1)-c1cc(OCC#C)cc(c1)C(=O)NCc1ncc(Cl)cc1F InChI=1S/C20H15ClFN3O2S/c1-3-4-27-16-6-13(5-14(7-16)20-25-9-12(2)28-20)19(26)24-11-18-17(22)8-15(21)10-23-18/h1,5-10H,4,11H2,2H3,(H,24,26) VKJAMZXKIQCHSG-UHFFFAOYSA-N 322220 N-[(5-Chloro-3- fluoropyridin-2- yl)methyl]-3-(5- methyl-1,3- thiazol-2-yl)-5- (prop-2-yn-1- yloxy) benzamide::US10183937, Example 32::US10202369, Example 32::US10472354, Example 32 P2X purinoceptor 3 Homo sapiens 24.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322220 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322220&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397185 384225297 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 682865 C[C@@H](NC(=O)c1cc(OCC#C)cc(c1)-c1ncc(C)s1)c1ccc(C)nc1 InChI=1S/C22H21N3O2S/c1-5-8-27-20-10-18(9-19(11-20)22-24-12-15(3)28-22)21(26)25-16(4)17-7-6-14(2)23-13-17/h1,6-7,9-13,16H,8H2,2-4H3,(H,25,26)/t16-/m1/s1 ZCHZUISZWKOUTB-MRXNPFEDSA-N 319866 N-[(1R)-1-(6- Methylpyridin- 3-yl)ethyl]-3- (5-methyl-1,3- thiazol-2-yl)-5- (prop-2-yn-1- yloxy) benzamide::US10174016, Example 33::US10202369, Example 33::US10472354, Example 33 P2X purinoceptor 3 Homo sapiens 29.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319866 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319866&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397790 384223146 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 682867 C[C@@H](NC(=O)c1cc(OCC#C)cc(c1)-c1ncc(C)s1)c1cnc(C)cn1 InChI=1S/C21H20N4O2S/c1-5-6-27-18-8-16(7-17(9-18)21-24-11-14(3)28-21)20(26)25-15(4)19-12-22-13(2)10-23-19/h1,7-12,15H,6H2,2-4H3,(H,25,26)/t15-/m1/s1 UJLVWKMINNYJSM-OAHLLOKOSA-N 319867 N-[(1R)-1-(5- Methylpyrazin- 2-yl)ethyl]-3- (5-methyl-1,3- thiazol-2-yl)-5- (prop-2-yn-1- yloxy) benzamide::US10174016, Example 34::US10202369, Example 34::US10472354, Example 34 P2X purinoceptor 3 Homo sapiens 111 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319867 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319867&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397514 384223147 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 682869 Cc1cnc(s1)-c1cc(OCC#C)cc(c1)C(=O)NCc1cnc(C)cn1 InChI=1S/C20H18N4O2S/c1-4-5-26-18-7-15(6-16(8-18)20-24-10-14(3)27-20)19(25)23-12-17-11-21-13(2)9-22-17/h1,6-11H,5,12H2,2-3H3,(H,23,25) HKQDCIZFKBUDQD-UHFFFAOYSA-N 319868 N-[(5- Methylpyrazin- 2-yl)methyl]- 3-(5-methyl- 1,3-thiazol-2- yl)-5-(prop-2- yn-1- yloxy)benzamide::US10174016, Example 35::US10202369, Example 35::US10472354, Example 35 P2X purinoceptor 3 Homo sapiens 460 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319868 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319868&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397704 384223148 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 682871 C[C@@H](NC(=O)c1cc(OCC#C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C21H17F3N4O2S/c1-4-5-30-17-7-14(6-15(8-17)19-25-9-12(2)31-19)18(29)28-13(3)16-10-26-20(27-11-16)21(22,23)24/h1,6-11,13H,5H2,2-3H3,(H,28,29)/t13-/m1/s1 BTRSFHCVZJPJKT-CYBMUJFWSA-N 319869 3-(5-Methyl- 1,3-thiazol-2- yl)-5-(prop-2- yn-1-yloxy)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 36::US10202369, Example 36::US10472354, Example 36 P2X purinoceptor 3 Homo sapiens 14.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319869 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319869&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397309 384223149 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 682873 C[C@@H](NC(=O)c1cc(OCC#C)cc(c1)-c1ncc(C)s1)c1ccc(C)nn1 InChI=1S/C21H20N4O2S/c1-5-8-27-18-10-16(9-17(11-18)21-22-12-14(3)28-21)20(26)23-15(4)19-7-6-13(2)24-25-19/h1,6-7,9-12,15H,8H2,2-4H3,(H,23,26)/t15-/m1/s1 IZIUFNSLLIEWJE-OAHLLOKOSA-N 319870 N-[(1R)-1-(6- Methylpyridazin- 3-yl)ethyl]- 3-(5-methyl- 1,3-thiazol-2- yl)-5-(prop-2- yn-1- yloxy) benzamide::US10174016, Example 37::US10202369, Example 37::US10472354, Example 37 P2X purinoceptor 3 Homo sapiens 55.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319870 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319870&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397261 384223150 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 682875 C[C@@H](NC(=O)c1cc(OCC#C)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F InChI=1S/C21H17F3N4O2S/c1-4-7-30-16-9-14(8-15(10-16)20-25-11-12(2)31-20)19(29)26-13(3)17-5-6-18(28-27-17)21(22,23)24/h1,5-6,8-11,13H,7H2,2-3H3,(H,26,29)/t13-/m1/s1 PNZFOFJAUOCDQW-CYBMUJFWSA-N 319871 3-(5-Methyl- 1,3-thiazol-2- yl)-5-(prop-2- yn-1-yloxy)-N- [(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl] benzamide::US10174016, Example 38::US10202369, Example 38::US10472354, Example 38 P2X purinoceptor 3 Homo sapiens 55.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319871 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319871&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397333 384223151 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 682877 C[C@@H](NC(=O)c1cc(OCC#C)cc(c1)-c1ncc(C)s1)c1cnc(C)nc1 InChI=1S/C21H20N4O2S/c1-5-6-27-19-8-16(7-17(9-19)21-24-10-13(2)28-21)20(26)25-14(3)18-11-22-15(4)23-12-18/h1,7-12,14H,6H2,2-4H3,(H,25,26)/t14-/m1/s1 OVENJFXCZONLOP-CQSZACIVSA-N 319872 N-[(1R)-1-(2- Methylpyrimidin- 5-yl)ethyl]- 3-(5-methyl- 1,3-thiazol-2- yl)-5-(prop-2- yn-1- yloxy) benzamide::US10174016, Example 39::US10202369, Example 39::US10472354, Example 39 P2X purinoceptor 3 Homo sapiens 81.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319872 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319872&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397588 384223152 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 682879 CC#CCOc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C22H19F3N4O2S/c1-4-5-6-31-18-8-15(7-16(9-18)20-26-10-13(2)32-20)19(30)29-14(3)17-11-27-21(28-12-17)22(23,24)25/h7-12,14H,6H2,1-3H3,(H,29,30)/t14-/m1/s1 XSZOYFWYESZINQ-CQSZACIVSA-N 319873 3-(But-2-yn-1- yloxy)-5-(5- methyl-1,3- thiazol-2-yl)- N-[(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl] benzamide::US10174016, Example 40::US10202369, Example 40::US10472354, Example 40 P2X purinoceptor 3 Homo sapiens 16.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319873 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319873&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397357 384223153 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 682881 CC#CCOc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1nnc(C)s1 InChI=1S/C20H20N4O2S2/c1-5-6-7-26-17-9-15(8-16(10-17)20-21-11-12(2)27-20)18(25)22-13(3)19-24-23-14(4)28-19/h8-11,13H,7H2,1-4H3,(H,22,25)/t13-/m1/s1 ORWZAOZYNYEGDS-CYBMUJFWSA-N 319874 3-(But-2-yn-1- yloxy)-N-[(1R)- 1-(5-methyl- 1,3,4- thiadiazol-2- yl)ethyl]-5-(5- methyl-1,3- thiazol-2- yl)benzamide::US10174016, Example 41::US10202369, Example 41::US10472354, Example 41 P2X purinoceptor 3 Homo sapiens 130 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319874 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319874&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397286 384223154 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 682883 C[C@@H](NC(=O)c1cc(OC2COC2)cc(c1)-c1ncc(C)s1)c1cnc(C)cn1 InChI=1S/C21H22N4O3S/c1-12-7-23-19(9-22-12)14(3)25-20(26)15-4-16(21-24-8-13(2)29-21)6-17(5-15)28-18-10-27-11-18/h4-9,14,18H,10-11H2,1-3H3,(H,25,26)/t14-/m1/s1 AWWAAAATSKEOQH-CQSZACIVSA-N 319875 N-[(1R)-1-(5-Methylpyrazin-2-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-(oxetan-3-yloxy)benzamide::US10174016, Example 42::US10202369, Example 42::US10472354, Example 42 P2X purinoceptor 3 Homo sapiens 129 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319875 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319875&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397394 384223155 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 682885 C[C@@H](NC(=O)c1cc(OC2COC2)cc(c1)-c1ncc(C)s1)c1cnc(C)nc1 InChI=1S/C21H22N4O3S/c1-12-7-24-21(29-12)16-4-15(5-18(6-16)28-19-10-27-11-19)20(26)25-13(2)17-8-22-14(3)23-9-17/h4-9,13,19H,10-11H2,1-3H3,(H,25,26)/t13-/m1/s1 QZYMXYIOESSIBG-CYBMUJFWSA-N 319876 N-[(1R)-1-(2-Methylpyrimidin-5-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-(oxetan-3-yloxy)benzamide::US10174016, Example 43::US10202369, Example 43::US10472354, Example 43 P2X purinoceptor 3 Homo sapiens 50.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319876 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319876&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397750 384223156 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 682887 CC(NC(=O)c1cc(OC2COC2)cc(c1)-c1ncc(C)s1)c1ncc(Cl)cc1F InChI=1S/C21H19ClFN3O3S/c1-11-7-25-21(30-11)14-3-13(4-16(5-14)29-17-9-28-10-17)20(27)26-12(2)19-18(23)6-15(22)8-24-19/h3-8,12,17H,9-10H2,1-2H3,(H,26,27) DXVSMJSLGFWBSV-UHFFFAOYSA-N 319877 N-[1-(5-Chloro-3-fluoropyridin-2-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-(oxetan-3-yloxy)benzamide::US10174016, Example 44::US10202369, Example 44::US10472354, Example 44 P2X purinoceptor 3 Homo sapiens 11.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319877 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319877&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397182 384223157 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 682889 Cc1cnc(s1)-c1cc(OC2COC2)cc(c1)C(=O)NCc1ccc(C)nn1 InChI=1S/C20H20N4O3S/c1-12-3-4-16(24-23-12)9-21-19(25)14-5-15(20-22-8-13(2)28-20)7-17(6-14)27-18-10-26-11-18/h3-8,18H,9-11H2,1-2H3,(H,21,25) AFIPEIBYSBBLBJ-UHFFFAOYSA-N 319878 N-[(6-Methylpyridazin-3-yl)methyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-(oxetan-3-yloxy)benzamide::US10174016, Example 45::US10202369, Example 45::US10472354, Example 45 P2X purinoceptor 3 Homo sapiens 212 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319878 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319878&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397740 384223158 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 682891 C[C@@H](NC(=O)c1cc(OC2COC2)cc(c1)-c1ncc(C)s1)c1ccc(Cl)cn1 InChI=1S/C21H20ClN3O3S/c1-12-8-24-21(29-12)15-5-14(6-17(7-15)28-18-10-27-11-18)20(26)25-13(2)19-4-3-16(22)9-23-19/h3-9,13,18H,10-11H2,1-2H3,(H,25,26)/t13-/m1/s1 FFCGGIUVAQWIMW-CYBMUJFWSA-N 319879 N-[(1R)-1-(5-Chloropyridin-2-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-(oxetan-3-yloxy)benzamide::US10174016, Example 46::US10202369, Example 46::US10472354, Example 46 P2X purinoceptor 3 Homo sapiens 10.00 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319879 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319879&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397660 384223159 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 682893 C[C@@H](NC(=O)c1cc(OC2COC2)cc(c1)-c1ncc(C)s1)c1ccc(C)nn1 InChI=1S/C21H22N4O3S/c1-12-4-5-19(25-24-12)14(3)23-20(26)15-6-16(21-22-9-13(2)29-21)8-17(7-15)28-18-10-27-11-18/h4-9,14,18H,10-11H2,1-3H3,(H,23,26)/t14-/m1/s1 HFDOVXXFUCEVBK-CQSZACIVSA-N 319880 N-[(1R)-1-(6-Methylpyridazin-3-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-(oxetan-3-yloxy)benzamide::US10174016, Example 47::US10202369, Example 47::US10472354, Example 47 P2X purinoceptor 3 Homo sapiens 82.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319880&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397352 384223160 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 682895 C[C@@H](NC(=O)c1cc(OC2COC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C21H19F3N4O3S/c1-11-6-25-19(32-11)14-3-13(4-16(5-14)31-17-9-30-10-17)18(29)28-12(2)15-7-26-20(27-8-15)21(22,23)24/h3-8,12,17H,9-10H2,1-2H3,(H,28,29)/t12-/m1/s1 HXNSKECKPLVRIH-GFCCVEGCSA-N 319881 3-(5-Methyl-1,3-thiazol-2-yl)-5-(oxetan-3-yloxy)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 48::US10202369, Example 48::US10472354, Example 48 P2X purinoceptor 3 Homo sapiens 14.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319881 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319881&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397291 384223161 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 682897 CC(NC(=O)c1cc(OC2COC2)cc(c1)-c1ncc(C)s1)c1ncc(F)cc1Cl InChI=1S/C21H19ClFN3O3S/c1-11-7-25-21(30-11)14-3-13(4-16(5-14)29-17-9-28-10-17)20(27)26-12(2)19-18(22)6-15(23)8-24-19/h3-8,12,17H,9-10H2,1-2H3,(H,26,27) FNMVOFQACWEVTO-UHFFFAOYSA-N 319882 N-[1-(3-Chloro-5-fluoropyridin-2-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-(oxetan-3-yloxy)benzamide::US10174016, Example 49::US10202369, Example 49::US10472354, Example 49 P2X purinoceptor 3 Homo sapiens 132 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319882 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319882&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397320 384223162 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 682899 C[C@@H](NC(=O)c1cc(OC2COC2)cc(c1)-c1ncc(C)s1)c1nnc(C)s1 InChI=1S/C19H20N4O3S2/c1-10-7-20-19(27-10)14-4-13(5-15(6-14)26-16-8-25-9-16)17(24)21-11(2)18-23-22-12(3)28-18/h4-7,11,16H,8-9H2,1-3H3,(H,21,24)/t11-/m1/s1 RQBQZBLVECLWLL-LLVKDONJSA-N 319883 N-[(1R)-1-(5-Methyl-1,3,4-thiadiazol-2-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-(oxetan-3-yloxy)benzamide::US10174016, Example 50::US10202369, Example 50 P2X purinoceptor 3 Homo sapiens 77.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319883 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319883&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397179 384223163 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 682901 C[C@@H](NC(=O)c1cc(OC2COC2)cc(c1)-c1ncc(C)s1)c1ccc(C)nc1 InChI=1S/C22H23N3O3S/c1-13-4-5-16(10-23-13)15(3)25-21(26)17-6-18(22-24-9-14(2)29-22)8-19(7-17)28-20-11-27-12-20/h4-10,15,20H,11-12H2,1-3H3,(H,25,26)/t15-/m1/s1 MHQNYPHPPSGTBD-OAHLLOKOSA-N 319884 N-[(1R)-1-(6-methylpyridin-3-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-(oxetan-3-yloxy)benzamide::US10174016, Example 51::US10202369, Example 51 P2X purinoceptor 3 Homo sapiens 74.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319884 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319884&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397804 384223164 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 682903 Cc1cnc(s1)-c1cc(OC2COC2)cc(c1)C(=O)NCc1ccc(nn1)C(F)(F)F InChI=1S/C20H17F3N4O3S/c1-11-7-25-19(31-11)13-4-12(5-15(6-13)30-16-9-29-10-16)18(28)24-8-14-2-3-17(27-26-14)20(21,22)23/h2-7,16H,8-10H2,1H3,(H,24,28) KTKYNBLLOZOZPY-UHFFFAOYSA-N 319885 3-(5-Methyl- 1,3-thiazol-2- yl)-5-(oxetan- 3-yloxy)-N-{[6- (trifluoromethyl) pyridazin-3- yl]methyl} benzamide::US10174016, Example 52::US10202369, Example 52::US10472354, Example 52 P2X purinoceptor 3 Homo sapiens 194 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319885 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319885&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397650 384223165 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 682905 CC[C@@H](NC(=O)c1cc(OC2COC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C22H21F3N4O3S/c1-3-18(15-8-27-21(28-9-15)22(23,24)25)29-19(30)13-4-14(20-26-7-12(2)33-20)6-16(5-13)32-17-10-31-11-17/h4-9,17-18H,3,10-11H2,1-2H3,(H,29,30)/t18-/m1/s1 PHCWFMJDVHAVQT-GOSISDBHSA-N 319886 3-(5-Methyl- 1,3-thiazol-2- yl)-5-(oxetan- 3-yloxy)-N- [(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]propyl] benzamide::US10174016, Example 53::US10202369, Example 53::US10472354, Example 53 P2X purinoceptor 3 Homo sapiens 318 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319886 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319886&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397526 384223166 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 682907 Cc1cnc(s1)-c1cc(OC[C@@H]2CCCO2)cc(c1)C(=O)NCc1ccc(C)nn1 InChI=1S/C22H24N4O3S/c1-14-5-6-18(26-25-14)12-23-21(27)16-8-17(22-24-11-15(2)30-22)10-20(9-16)29-13-19-4-3-7-28-19/h5-6,8-11,19H,3-4,7,12-13H2,1-2H3,(H,23,27)/t19-/m0/s1 IFCRFQDQDLUKDL-IBGZPJMESA-N 319887 N-[(6-Methylpyridazin-3-yl)methyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(2S)-tetrahydrofuran-2-ylmethoxy]benzamide::US10174016, Example 54::US10202369, Example 54::US10472354, Example 54 P2X purinoceptor 3 Homo sapiens 66.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319887 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319887&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397485 384223167 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 682909 Cc1cnc(s1)-c1cc(OC[C@@H]2CCCO2)cc(c1)C(=O)NCc1ncc(Cl)cc1F InChI=1S/C22H21ClFN3O3S/c1-13-9-27-22(31-13)15-5-14(6-18(7-15)30-12-17-3-2-4-29-17)21(28)26-11-20-19(24)8-16(23)10-25-20/h5-10,17H,2-4,11-12H2,1H3,(H,26,28)/t17-/m0/s1 UTQWAUZOCBGCBP-KRWDZBQOSA-N 322243 US10183937, Example 55::US10202369, Example 55 P2X purinoceptor 3 Homo sapiens 8.00 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322243 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322243&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397391 384225320 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 682911 Cc1cnc(s1)-c1cc(OC[C@@H]2CCCO2)cc(c1)C(=O)NCc1cnc(C)cn1 InChI=1S/C22H24N4O3S/c1-14-9-24-18(11-23-14)12-25-21(27)16-6-17(22-26-10-15(2)30-22)8-20(7-16)29-13-19-4-3-5-28-19/h6-11,19H,3-5,12-13H2,1-2H3,(H,25,27)/t19-/m0/s1 UMCJOKLDVAQWOA-IBGZPJMESA-N 319889 N-[(5-Methylpyrazin-2-yl)methyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(2S)-tetrahydrofuran-2-ylmethoxy]benzamide::US10174016, Example 56::US10202369, Example 56 P2X purinoceptor 3 Homo sapiens 148 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319889 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319889&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397398 384223169 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 682913 C[C@@H](NC(=O)c1cc(OC[C@@H]2CCCO2)cc(c1)-c1ncc(C)s1)c1cnc(C)cn1 InChI=1S/C23H26N4O3S/c1-14-10-25-21(12-24-14)16(3)27-22(28)17-7-18(23-26-11-15(2)31-23)9-20(8-17)30-13-19-5-4-6-29-19/h7-12,16,19H,4-6,13H2,1-3H3,(H,27,28)/t16-,19+/m1/s1 MANPQCKCYFRFOG-APWZRJJASA-N 319890 N-[(1R)-1-(5-Methylpyrazin-2-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(2S)-tetrahydrofuran-2-ylmethoxy]benzamide::US10174016, Example 57::US10202369, Example 57::US10472354, Example 57 P2X purinoceptor 3 Homo sapiens 25.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319890 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319890&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397390 384223170 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 682915 C[C@@H](NC(=O)c1cc(OC[C@@H]2CCCO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H23F3N4O3S/c1-13-9-27-21(34-13)16-6-15(7-19(8-16)33-12-18-4-3-5-32-18)20(31)30-14(2)17-10-28-22(29-11-17)23(24,25)26/h6-11,14,18H,3-5,12H2,1-2H3,(H,30,31)/t14-,18+/m1/s1 MXZPUDRHAAYJOR-KDOFPFPSSA-N 319891 3-(5-Methyl-1,3-thiazol-2-yl)-5-[(2S)-tetrahydrofuran-2-ylmethoxy]-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 58::US10202369, Example 58::US10472354, Example 58 P2X purinoceptor 3 Homo sapiens 4.00 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319891 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319891&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397134 384223171 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 682917 C[C@@H](NC(=O)c1cc(OC[C@@H]2CCCO2)cc(c1)-c1ncc(C)s1)c1ccc(C)nn1 InChI=1S/C23H26N4O3S/c1-14-6-7-21(27-26-14)16(3)25-22(28)17-9-18(23-24-12-15(2)31-23)11-20(10-17)30-13-19-5-4-8-29-19/h6-7,9-12,16,19H,4-5,8,13H2,1-3H3,(H,25,28)/t16-,19+/m1/s1 JHPJVAOLQKHAFN-APWZRJJASA-N 319892 N-[(1R)-1-(6-Methylpyridazin-3-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(2S)-tetrahydrofuran-2-ylmethoxy]benzamide::US10174016, Example 59::US10202369, Example 59::US10472354, Example 59 P2X purinoceptor 3 Homo sapiens 13.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319892 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319892&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397721 384223172 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 682919 C[C@@H](NC(=O)c1cc(OC[C@@H]2CCCO2)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F InChI=1S/C23H23F3N4O3S/c1-13-11-27-22(34-13)16-8-15(9-18(10-16)33-12-17-4-3-7-32-17)21(31)28-14(2)19-5-6-20(30-29-19)23(24,25)26/h5-6,8-11,14,17H,3-4,7,12H2,1-2H3,(H,28,31)/t14-,17+/m1/s1 KNJYTDFISMIFTK-PBHICJAKSA-N 319893 3-(5-Methyl-1,3-thiazol-2-yl)-5-[(2S)-tetrahydrofuran-2-ylmethoxy]-N-{(1R)-1-[6-(trifluoromethyl)pyridazin-3-yl]ethyl}benzamide::US10174016, Example 60::US10202369, Example 60::US10472354, Example 60 P2X purinoceptor 3 Homo sapiens 11.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319893 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319893&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397124 384223173 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 682921 C[C@@H](NC(=O)c1cc(OC[C@H]2CCCO2)cc(c1)-c1ncc(C)s1)c1ccc(C)nn1 InChI=1S/C23H26N4O3S/c1-14-6-7-21(27-26-14)16(3)25-22(28)17-9-18(23-24-12-15(2)31-23)11-20(10-17)30-13-19-5-4-8-29-19/h6-7,9-12,16,19H,4-5,8,13H2,1-3H3,(H,25,28)/t16-,19-/m1/s1 JHPJVAOLQKHAFN-VQIMIIECSA-N 319894 N-[(1R)-1-(6-methylpyridazin-3-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(2R)-tetrahydrofuran-2-ylmethoxy]benzamide::US10174016, Example 61::US10202369, Example 61::US10472354, Example 61 P2X purinoceptor 3 Homo sapiens 14.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319894 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319894&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397475 384223174 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 682923 Cc1cnc(s1)-c1cc(OC[C@H]2CCCO2)cc(c1)C(=O)NCc1ccc(C)nn1 InChI=1S/C22H24N4O3S/c1-14-5-6-18(26-25-14)12-23-21(27)16-8-17(22-24-11-15(2)30-22)10-20(9-16)29-13-19-4-3-7-28-19/h5-6,8-11,19H,3-4,7,12-13H2,1-2H3,(H,23,27)/t19-/m1/s1 IFCRFQDQDLUKDL-LJQANCHMSA-N 319895 N-[(6-Methylpyridazin-3-yl)methyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(2R)-tetrahydrofuran-2-ylmethoxy]benzamide::US10174016, Example 62::US10202369, Example 62::US10472354, Example 62 P2X purinoceptor 3 Homo sapiens 85.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319895 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319895&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397725 384223175 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 682925 C[C@@H](NC(=O)c1cc(OC[C@H]2CCCO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H23F3N4O3S/c1-13-9-27-21(34-13)16-6-15(7-19(8-16)33-12-18-4-3-5-32-18)20(31)30-14(2)17-10-28-22(29-11-17)23(24,25)26/h6-11,14,18H,3-5,12H2,1-2H3,(H,30,31)/t14-,18-/m1/s1 MXZPUDRHAAYJOR-RDTXWAMCSA-N 319896 3-(5-Methyl-1,3-thiazol-2-yl)-5-[(2R)-tetrahydrofuran-2-ylmethoxy]-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 63::US10202369, Example 63::US10472354, Example 63 P2X purinoceptor 3 Homo sapiens 4.00 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319896 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319896&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397292 384223176 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 682927 C[C@@H](NC(=O)c1cc(OC[C@H]2CCCO2)cc(c1)-c1ncc(C)s1)c1cnc(C)cn1 InChI=1S/C23H26N4O3S/c1-14-10-25-21(12-24-14)16(3)27-22(28)17-7-18(23-26-11-15(2)31-23)9-20(8-17)30-13-19-5-4-6-29-19/h7-12,16,19H,4-6,13H2,1-3H3,(H,27,28)/t16-,19-/m1/s1 MANPQCKCYFRFOG-VQIMIIECSA-N 319897 N-[(1R)-1-(5-methylpyrazin-2-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(2R)-tetrahydrofuran-2-ylmethoxy]benzamide::US10174016, Example 64::US10202369, Example 64::US10472354, Example 64 P2X purinoceptor 3 Homo sapiens 53.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319897 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319897&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397244 384223177 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683457 C[C@@H](NC(=O)c1cc(OCC2(C)CCCO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H25F3N4O3S/c1-14-10-28-21(35-14)17-7-16(8-19(9-17)33-13-23(3)5-4-6-34-23)20(32)31-15(2)18-11-29-22(30-12-18)24(25,26)27/h7-12,15H,4-6,13H2,1-3H3,(H,31,32)/t15-,23?/m1/s1 LFYNTNZWPQXJEM-NKTHEXPSSA-N 320162 3-[(2-methyltetrahydrofuran-2-yl)methoxy]-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide, as a mixture of two diastereoisomers::US10174016, Example 329::US10202369, Example 330::US10472354, Example 332 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320162 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320162&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397698 384223436 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683459 C[C@@H](NC(=O)c1cc(OCC2(C)CCCO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H25F3N4O3S/c1-14-10-28-21(35-14)17-7-16(8-19(9-17)33-13-23(3)5-4-6-34-23)20(32)31-15(2)18-11-29-22(30-12-18)24(25,26)27/h7-12,15H,4-6,13H2,1-3H3,(H,31,32)/t15-,23?/m1/s1 LFYNTNZWPQXJEM-NKTHEXPSSA-N 320162 3-[(2-methyltetrahydrofuran-2-yl)methoxy]-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide, as a mixture of two diastereoisomers::US10174016, Example 329::US10202369, Example 330::US10472354, Example 332 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320162 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320162&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397698 384223436 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683461 C[C@H](NC(=O)c1cc(OCC2(C)CCCO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H25F3N4O3S/c1-14-10-28-21(35-14)17-7-16(8-19(9-17)33-13-23(3)5-4-6-34-23)20(32)31-15(2)18-11-29-22(30-12-18)24(25,26)27/h7-12,15H,4-6,13H2,1-3H3,(H,31,32)/t15-,23?/m0/s1 LFYNTNZWPQXJEM-NGMICRHFSA-N 322520 US10183937, Example 331::US10202369, Example 331 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322520 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322520&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 138375412 384225582 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683463 C[C@@H](NC(=O)c1cc(OCC2(C)CCOC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H25F3N4O3S/c1-14-9-28-21(35-14)17-6-16(7-19(8-17)34-13-23(3)4-5-33-12-23)20(32)31-15(2)18-10-29-22(30-11-18)24(25,26)27/h6-11,15H,4-5,12-13H2,1-3H3,(H,31,32)/t15-,23?/m1/s1 FUZHKJYNGBDBHI-NKTHEXPSSA-N 320165 3-[(3-methyltetrahydrofuran-3-yl)methoxy]-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide, as a Mixture of Two Diastereoisomers::US10174016, Example 332::US10202369, Example 333 P2X purinoceptor 3 Homo sapiens 4.00 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320165 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320165&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397763 384223439 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683465 C[C@@H](NC(=O)c1cc(OCC2(C)CCOC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H25F3N4O3S/c1-14-9-28-21(35-14)17-6-16(7-19(8-17)34-13-23(3)4-5-33-12-23)20(32)31-15(2)18-10-29-22(30-11-18)24(25,26)27/h6-11,15H,4-5,12-13H2,1-3H3,(H,31,32)/t15-,23?/m1/s1 FUZHKJYNGBDBHI-NKTHEXPSSA-N 320165 3-[(3-methyltetrahydrofuran-3-yl)methoxy]-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide, as a Mixture of Two Diastereoisomers::US10174016, Example 332::US10202369, Example 333 P2X purinoceptor 3 Homo sapiens 4.00 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320165 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320165&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397763 384223439 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683467 C[C@H](NC(=O)c1cc(OCC2(C)CCOC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H25F3N4O3S/c1-14-9-28-21(35-14)17-6-16(7-19(8-17)34-13-23(3)4-5-33-12-23)20(32)31-15(2)18-10-29-22(30-11-18)24(25,26)27/h6-11,15H,4-5,12-13H2,1-3H3,(H,31,32)/t15-,23?/m0/s1 FUZHKJYNGBDBHI-NGMICRHFSA-N 322523 US10183937, Example 334::US10202369, Example 334 P2X purinoceptor 3 Homo sapiens 4.00 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322523 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322523&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 138375413 384225584 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683469 C[C@@H](NC(=O)c1cc(OC2CCC(=O)N(C)C2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H24F3N5O3S/c1-13-9-28-22(36-13)16-6-15(7-19(8-16)35-18-4-5-20(33)32(3)12-18)21(34)31-14(2)17-10-29-23(30-11-17)24(25,26)27/h6-11,14,18H,4-5,12H2,1-3H3,(H,31,34)/t14-,18?/m1/s1 CGMVCPWOPCCFBE-IKJXHCRLSA-N 320168 3-[(1-methyl-6-oxopiperidin-3-yl)oxy]-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide, as a mixture of two diastereoisomers::US10174016, Example 335::US10202369, Example 336::US10472354, Example 335 P2X purinoceptor 3 Homo sapiens 13.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320168 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320168&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397147 384223442 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683471 C[C@@H](NC(=O)c1cc(OC2CCC(=O)N(C)C2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H24F3N5O3S/c1-13-9-28-22(36-13)16-6-15(7-19(8-16)35-18-4-5-20(33)32(3)12-18)21(34)31-14(2)17-10-29-23(30-11-17)24(25,26)27/h6-11,14,18H,4-5,12H2,1-3H3,(H,31,34)/t14-,18?/m1/s1 CGMVCPWOPCCFBE-IKJXHCRLSA-N 320168 3-[(1-methyl-6-oxopiperidin-3-yl)oxy]-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide, as a mixture of two diastereoisomers::US10174016, Example 335::US10202369, Example 336::US10472354, Example 335 P2X purinoceptor 3 Homo sapiens 14.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320168 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320168&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397147 384223442 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683473 C[C@H](NC(=O)c1cc(OC2CCC(=O)N(C)C2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H24F3N5O3S/c1-13-9-28-22(36-13)16-6-15(7-19(8-16)35-18-4-5-20(33)32(3)12-18)21(34)31-14(2)17-10-29-23(30-11-17)24(25,26)27/h6-11,14,18H,4-5,12H2,1-3H3,(H,31,34)/t14-,18?/m0/s1 CGMVCPWOPCCFBE-PIVQAISJSA-N 322526 US10183937, Example 337::US10202369, Example 337 P2X purinoceptor 3 Homo sapiens 13.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322526 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322526&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 138375414 384225586 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683475 CC(O)C(C)Oc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C22H23F3N4O3S/c1-11-8-26-20(33-11)16-5-15(6-18(7-16)32-14(4)13(3)30)19(31)29-12(2)17-9-27-21(28-10-17)22(23,24)25/h5-10,12-14,30H,1-4H3,(H,29,31)/t12-,13?,14?/m1/s1 FSGDRFBLPAILDE-IYXRBSQSSA-N 319995 3-{[3-hydroxybutan-2-yl]oxy}-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 162::US10174016, Example 338::US10202369, Example 339::US10472354, Example 338 P2X purinoceptor 3 Homo sapiens 4.00 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319995 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319995&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397269 384223275 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683477 CC(O)C(C)Oc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C22H23F3N4O3S/c1-11-8-26-20(33-11)16-5-15(6-18(7-16)32-14(4)13(3)30)19(31)29-12(2)17-9-27-21(28-10-17)22(23,24)25/h5-10,12-14,30H,1-4H3,(H,29,31)/t12-,13?,14?/m1/s1 FSGDRFBLPAILDE-IYXRBSQSSA-N 319995 3-{[3-hydroxybutan-2-yl]oxy}-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 162::US10174016, Example 338::US10202369, Example 339::US10472354, Example 338 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319995 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319995&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397269 384223275 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683479 CC(O)C(C)Oc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C22H23F3N4O3S/c1-11-8-26-20(33-11)16-5-15(6-18(7-16)32-14(4)13(3)30)19(31)29-12(2)17-9-27-21(28-10-17)22(23,24)25/h5-10,12-14,30H,1-4H3,(H,29,31)/t12-,13?,14?/m0/s1 FSGDRFBLPAILDE-HSBZDZAISA-N 319996 US10174016, Example 163::US10202369, Example 340::US10472354, Example 162 P2X purinoceptor 3 Homo sapiens 3.00 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319996 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319996&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134328174 384223276 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683481 C[C@@H](NC(=O)c1cc(OC2C3COCC2CN(C)C3)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C26H28F3N5O3S/c1-14-7-30-24(38-14)17-4-16(23(35)33-15(2)18-8-31-25(32-9-18)26(27,28)29)5-21(6-17)37-22-19-10-34(3)11-20(22)13-36-12-19/h4-9,15,19-20,22H,10-13H2,1-3H3,(H,33,35)/t15-,19?,20?,22?/m1/s1 UOQSAFNLRPUQCS-DSXPMEPHSA-N 320174 3-[(7-methyl-3-oxa-7-azabicyclo[3.3.1]non-9-yl)oxy]-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide, as a Mixture of Two Stereoisomers::US10174016, Example 341::US10202369, Example 342::US10472354, Example 343 P2X purinoceptor 3 Homo sapiens 41.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320174 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320174&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397140 384223447 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683483 C[C@@H](NC(=O)c1cc(OC2C3COCC2CN(C)C3)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C26H28F3N5O3S/c1-14-7-30-24(38-14)17-4-16(23(35)33-15(2)18-8-31-25(32-9-18)26(27,28)29)5-21(6-17)37-22-19-10-34(3)11-20(22)13-36-12-19/h4-9,15,19-20,22H,10-13H2,1-3H3,(H,33,35)/t15-,19?,20?,22?/m1/s1 UOQSAFNLRPUQCS-DSXPMEPHSA-N 320174 3-[(7-methyl-3-oxa-7-azabicyclo[3.3.1]non-9-yl)oxy]-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide, as a Mixture of Two Stereoisomers::US10174016, Example 341::US10202369, Example 342::US10472354, Example 343 P2X purinoceptor 3 Homo sapiens 40.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320174 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320174&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397140 384223447 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683485 C[C@H](NC(=O)c1cc(OC2C3COCC2CN(C)C3)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C26H28F3N5O3S/c1-14-7-30-24(38-14)17-4-16(23(35)33-15(2)18-8-31-25(32-9-18)26(27,28)29)5-21(6-17)37-22-19-10-34(3)11-20(22)13-36-12-19/h4-9,15,19-20,22H,10-13H2,1-3H3,(H,33,35)/t15-,19?,20?,22?/m0/s1 UOQSAFNLRPUQCS-LONTXVJRSA-N 320176 US10174016, Example 343::US10202369, Example 343 P2X purinoceptor 3 Homo sapiens 135 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320176 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320176&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 138374917 384223449 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683487 CC(C)N1CC2COCC(C1)C2Oc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C28H32F3N5O3S/c1-15(2)36-11-21-13-38-14-22(12-36)24(21)39-23-6-18(5-19(7-23)26-32-8-16(3)40-26)25(37)35-17(4)20-9-33-27(34-10-20)28(29,30)31/h5-10,15,17,21-22,24H,11-14H2,1-4H3,(H,35,37)/t17-,21?,22?,24?/m1/s1 IQKMSJWJAJKSIQ-CBDSMJNHSA-N 320177 3-[(7-isopropyl-3-oxa-7-azabicyclo[3.3.1]non-9-yl)oxy]-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide, as a mixture of two stereoisomers::US10174016, Example 344::US10202369, Example 344::US10472354, Example 344 P2X purinoceptor 3 Homo sapiens 34.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320177 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320177&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397285 384223450 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683489 COC(=O)N1CC2COCC(C1)C2Oc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C27H28F3N5O5S/c1-14-7-31-24(41-14)17-4-16(23(36)34-15(2)18-8-32-25(33-9-18)27(28,29)30)5-21(6-17)40-22-19-10-35(26(37)38-3)11-20(22)13-39-12-19/h4-9,15,19-20,22H,10-13H2,1-3H3,(H,34,36)/t15-,19?,20?,22?/m1/s1 GHSFQGHMPBJNHK-DSXPMEPHSA-N 320178 US10174016, Example 345::US10202369, Example 345::methyl 9-[3-(5-methyl-1,3-thiazol-2-yl)-5-({(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}carbamoyl)phenoxy]-3-oxa-7-azabicycle[3.3.1]nonane-7-carboxylate, as a mixture of two stereoisomers P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320178 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320178&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397363 384223451 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683491 C[C@@H](NC(=O)c1cc(OC[C@H]2CN(CCO2)C(=O)OC(C)(C)C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C28H32F3N5O5S/c1-16-11-32-24(42-16)19-8-18(23(37)35-17(2)20-12-33-25(34-13-20)28(29,30)31)9-21(10-19)40-15-22-14-36(6-7-39-22)26(38)41-27(3,4)5/h8-13,17,22H,6-7,14-15H2,1-5H3,(H,35,37)/t17-,22-/m1/s1 OEKUZTDVCYAZBS-VGOFRKELSA-N 320179 Tert-butyl (2R)-2-{[3-(5-methyl-1,3-thiazol-2-yl)-5-({(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}carbamoyl)phenoxy]methyl}morpholine-4-carboxylate::US10174016, Example 346::US10202369, Example 346::US10472354, Example 346 P2X purinoceptor 3 Homo sapiens 13.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320179 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320179&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134338449 384223452 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683493 C[C@@H](NC(=O)c1cc(OC[C@H]2CNCCO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H24F3N5O3S/c1-13-8-28-21(35-13)16-5-15(6-18(7-16)34-12-19-11-27-3-4-33-19)20(32)31-14(2)17-9-29-22(30-10-17)23(24,25)26/h5-10,14,19,27H,3-4,11-12H2,1-2H3,(H,31,32)/t14-,19-/m1/s1 HRVUBTPQOQIHTK-AUUYWEPGSA-N 320180 3-(5-Methyl-1,3-thiazol-2-yl)-5-[(2R)-morpholin-2-ylmethoxy]-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 347::US10202369, Example 347::US10472354, Example 347 P2X purinoceptor 3 Homo sapiens 9.00 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320180 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320180&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397601 384223453 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683495 C[C@@H](NC(=O)c1cc(OC[C@H]2CN(C)CCO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H26F3N5O3S/c1-14-9-28-22(36-14)17-6-16(7-19(8-17)35-13-20-12-32(3)4-5-34-20)21(33)31-15(2)18-10-29-23(30-11-18)24(25,26)27/h6-11,15,20H,4-5,12-13H2,1-3H3,(H,31,33)/t15-,20-/m1/s1 MROBUJILSMBILX-FOIQADDNSA-N 320181 3-{[(2R)-4-methylmorpholin-2-yl]methoxy}-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 348::US10202369, Example 348::US10472354, Example 348 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320181 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320181&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397607 384223454 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683497 C[C@@H](NC(=O)c1cc(OC[C@@H]2CN(CCO2)C(=O)OC(C)(C)C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C28H32F3N5O5S/c1-16-11-32-24(42-16)19-8-18(23(37)35-17(2)20-12-33-25(34-13-20)28(29,30)31)9-21(10-19)40-15-22-14-36(6-7-39-22)26(38)41-27(3,4)5/h8-13,17,22H,6-7,14-15H2,1-5H3,(H,35,37)/t17-,22+/m1/s1 OEKUZTDVCYAZBS-VGSWGCGISA-N 320182 Tert-butyl (2S)-2-{[3-(5-methyl-1,3-thiazol-2-yl)-5-({(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}carbamoyl)phenoxy]methyl}morpholine-4-carboxylate::US10174016, Example 349::US10202369, Example 349::US10472354, Example 349 P2X purinoceptor 3 Homo sapiens 23.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320182 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320182&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134338450 384223455 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683499 C[C@@H](NC(=O)c1cc(OC[C@@H]2CNCCO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H24F3N5O3S/c1-13-8-28-21(35-13)16-5-15(6-18(7-16)34-12-19-11-27-3-4-33-19)20(32)31-14(2)17-9-29-22(30-10-17)23(24,25)26/h5-10,14,19,27H,3-4,11-12H2,1-2H3,(H,31,32)/t14-,19+/m1/s1 HRVUBTPQOQIHTK-KUHUBIRLSA-N 320183 3-(5-Methyl-1,3-thiazol-2-yl)-5-[(2S)-morpholin-2-ylmethoxy]-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 350::US10202369, Example 350::US10472354, Example 350 P2X purinoceptor 3 Homo sapiens 14.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320183 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320183&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397343 384223456 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683501 C[C@@H](NC(=O)c1cc(OC[C@@H]2CN(C)CCO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H26F3N5O3S/c1-14-9-28-22(36-14)17-6-16(7-19(8-17)35-13-20-12-32(3)4-5-34-20)21(33)31-15(2)18-10-29-23(30-11-18)24(25,26)27/h6-11,15,20H,4-5,12-13H2,1-3H3,(H,31,33)/t15-,20+/m1/s1 MROBUJILSMBILX-QRWLVFNGSA-N 320184 3-{[(2S)-4-methylmorpholin-2-yl]methoxy}-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 351::US10202369, Example 351::US10472354, Example 351 P2X purinoceptor 3 Homo sapiens 16.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320184 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320184&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397379 384223457 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683503 C[C@@H](NC(=O)c1cc(OCC2CNCCO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H24F3N5O3S/c1-13-8-28-21(35-13)16-5-15(6-18(7-16)34-12-19-11-27-3-4-33-19)20(32)31-14(2)17-9-29-22(30-10-17)23(24,25)26/h5-10,14,19,27H,3-4,11-12H2,1-2H3,(H,31,32)/t14-,19?/m1/s1 HRVUBTPQOQIHTK-MJTSIZKDSA-N 320185 3-(5-Methyl-1,3-thiazol-2-yl)-5-[morpholin-2-ylmethoxy]-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide, Formed as a Mixture of Example 347 (Diastereoisomer 1) and Example 350 (Diastereoisomer 2)::US10174016, Example 352::US10202369, Example 352::US10472354, Example 352 P2X purinoceptor 3 Homo sapiens 18.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320185 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320185&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397625 384223458 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683505 C[C@@H](NC(=O)c1cc(OCC2CN(C)CCO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H26F3N5O3S/c1-14-9-28-22(36-14)17-6-16(7-19(8-17)35-13-20-12-32(3)4-5-34-20)21(33)31-15(2)18-10-29-23(30-11-18)24(25,26)27/h6-11,15,20H,4-5,12-13H2,1-3H3,(H,31,33)/t15-,20?/m1/s1 MROBUJILSMBILX-IWPPFLRJSA-N 320186 3-{[4-methylmorpholin-2-yl]methoxy}-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide, formed as a mixture of Example 348 (Diastereoisomer 2) and Example 351 (Diastereoisomer 1)::US10174016, Example 353::US10202369, Example 353::US10472354, Example 353 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320186 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320186&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397299 384223459 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683507 C[C@@H](NC(=O)c1cc(OCC2(F)CCCNC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H25F4N5O2S/c1-14-9-30-21(36-14)17-6-16(7-19(8-17)35-13-23(25)4-3-5-29-12-23)20(34)33-15(2)18-10-31-22(32-11-18)24(26,27)28/h6-11,15,29H,3-5,12-13H2,1-2H3,(H,33,34)/t15-,23?/m1/s1 KEYDTZMORFCFGJ-NKTHEXPSSA-N 322543 3-(Fluoropiperidin-3-yl)methoxy}-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10183937, Example 354::US10202369, Example 354 P2X purinoceptor 3 Homo sapiens 25.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322543 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322543&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134338435 384225603 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683509 C[C@H](NC(=O)c1cc(OCC2(F)CCCNC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H25F4N5O2S/c1-14-9-30-21(36-14)17-6-16(7-19(8-17)35-13-23(25)4-3-5-29-12-23)20(34)33-15(2)18-10-31-22(32-11-18)24(26,27)28/h6-11,15,29H,3-5,12-13H2,1-2H3,(H,33,34)/t15-,23?/m0/s1 KEYDTZMORFCFGJ-NGMICRHFSA-N 322544 US10183937, Example 355::US10202369, Example 355 P2X purinoceptor 3 Homo sapiens 9.00 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322544 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322544&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 138375416 384225604 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683511 C[C@@H](NC(=O)c1cc(OCC2(F)CCCN(C)C2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C25H27F4N5O2S/c1-15-10-30-22(37-15)18-7-17(8-20(9-18)36-14-24(26)5-4-6-34(3)13-24)21(35)33-16(2)19-11-31-23(32-12-19)25(27,28)29/h7-12,16H,4-6,13-14H2,1-3H3,(H,33,35)/t16-,24?/m1/s1 JEEGJUGZAOELQB-YAOANENCSA-N 322545 US10183937, Example 356::US10202369, Example 356 P2X purinoceptor 3 Homo sapiens 29.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322545 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322545&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397155 384225605 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683513 C[C@H](NC(=O)c1cc(OCC2(F)CCCN(C)C2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C25H27F4N5O2S/c1-15-10-30-22(37-15)18-7-17(8-20(9-18)36-14-24(26)5-4-6-34(3)13-24)21(35)33-16(2)19-11-31-23(32-12-19)25(27,28)29/h7-12,16H,4-6,13-14H2,1-3H3,(H,33,35)/t16-,24?/m0/s1 JEEGJUGZAOELQB-FXIRQEPWSA-N 322546 US10183937, Example 357::US10202369, Example 357 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322546 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322546&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 138375417 384225606 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683515 C[C@@H](NC(=O)c1cc(OCC2(F)CNC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C22H21F4N5O2S/c1-12-6-28-19(34-12)15-3-14(4-17(5-15)33-11-21(23)9-27-10-21)18(32)31-13(2)16-7-29-20(30-8-16)22(24,25)26/h3-8,13,27H,9-11H2,1-2H3,(H,31,32)/t13-/m1/s1 BCJGFEUMNVQMPR-CYBMUJFWSA-N 320191 3-[(3- fluoroazetidin- 3-yl)methoxy]- 5-(5-methyl- 1,3-thiazol-2- yl)-N-{(1R)-1- [2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 358::US10202369, Example 358::US10472354, Example 358 P2X purinoceptor 3 Homo sapiens 57.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320191 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320191&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397395 384223464 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683517 C[C@@H](NC(=O)c1cc(OCC2CNCCC2(F)F)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H24F5N5O2S/c1-13-8-31-21(37-13)16-5-15(6-19(7-16)36-12-18-11-30-4-3-23(18,25)26)20(35)34-14(2)17-9-32-22(33-10-17)24(27,28)29/h5-10,14,18,30H,3-4,11-12H2,1-2H3,(H,34,35)/t14-,18?/m1/s1 GMFUIUUSPXQCGC-IKJXHCRLSA-N 320192 3-{[4,4- difluoropiperidin- 3- yl]methoxy}-5- (5-methyl-1,3- thiazol-2-yl)- N-{(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide, as a mixture of 2 diastereoisomers::US10174016, Example 359::US10202369, Example 359::US10472354, Example 359 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320192 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320192&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397568 384223465 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683519 C[C@@H](NC(=O)c1cc(OC[C@H]2COCCN2C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H26F3N5O3S/c1-14-9-28-22(36-14)17-6-16(7-20(8-17)35-13-19-12-34-5-4-32(19)3)21(33)31-15(2)18-10-29-23(30-11-18)24(25,26)27/h6-11,15,19H,4-5,12-13H2,1-3H3,(H,31,33)/t15-,19-/m1/s1 QQIYVSYWBHUFSE-DNVCBOLYSA-N 320193 3-{[(3R)-4-methylmorpholin-3-yl]methoxyl}-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 360::US10202369, Example 360::US10472354, Example 360 P2X purinoceptor 3 Homo sapiens 10.00 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320193 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320193&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397664 384223466 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 683521 C[C@@H](NC(=O)c1cc(OC[C@@H]2COCCN2C)cc(c1)-c1ncc(C)s1)c1ccc(nc1)C(F)(F)F InChI=1S/C25H27F3N4O3S/c1-15-11-30-24(36-15)19-8-18(9-21(10-19)35-14-20-13-34-7-6-32(20)3)23(33)31-16(2)17-4-5-22(29-12-17)25(26,27)28/h4-5,8-12,16,20H,6-7,13-14H2,1-3H3,(H,31,33)/t16-,20+/m1/s1 VDLXIDIXMUFWTI-UZLBHIALSA-N 320194 3-{[(3S)-4- methylmorpholin- 3- yl]methoxy}-5- (5-methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[6- (trifluoromethyl) pyridin-3- yl]ethyl} benzamide::US10174016, Example 361::US10202369, Example 361::US10472354, Example 361 P2X purinoceptor 3 Homo sapiens 14.0 US Patent 10.7270/Q2TT4T2P aid1797299 US10202369 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320194 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320194&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397445 384223467 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 50952177 CCOC(=O)c1ccc(cc1)N1C(C(C(=O)c2ccccc2)=C(O)C1=O)c1ccccc1 InChI=1S/C26H21NO5/c1-2-32-26(31)19-13-15-20(16-14-19)27-22(17-9-5-3-6-10-17)21(24(29)25(27)30)23(28)18-11-7-4-8-12-18/h3-16,22,29H,2H2,1H3 NYOUOYCQZDXQHV-UHFFFAOYSA-N 50274320 CHEMBL4129977 P2X purinoceptor 3 Homo sapiens 370 ChEMBL 10.1016/j.bmcl.2017.04.060 10.7270/Q2W95CP6 29805055 Tobinaga, H; Kameyama, T; Oohara, M; Kobayashi, N; Ohdan, M; Ishizuka, N; Kume, M; Tomari, M; Tanaka, Y; Takahashi, F; Kinoshita, H; Shimada, S; Shinohara, S; Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50274320 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50274320&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 5935441 104118135 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 50952178 CCOC(=O)c1ccc(cc1)N1C(C(C(=O)c2ccc(OC)cc2)=C(O)C1=O)c1ccccc1Cl InChI=1S/C27H22ClNO6/c1-3-35-27(33)17-8-12-18(13-9-17)29-23(20-6-4-5-7-21(20)28)22(25(31)26(29)32)24(30)16-10-14-19(34-2)15-11-16/h4-15,23,31H,3H2,1-2H3 ATXHFLFIZNYCIY-UHFFFAOYSA-N 50274321 CHEMBL4127346 P2X purinoceptor 3 Homo sapiens 90 ChEMBL 10.1016/j.bmcl.2017.04.060 10.7270/Q2W95CP6 29805055 Tobinaga, H; Kameyama, T; Oohara, M; Kobayashi, N; Ohdan, M; Ishizuka, N; Kume, M; Tomari, M; Tanaka, Y; Takahashi, F; Kinoshita, H; Shimada, S; Shinohara, S; Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50274321 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50274321&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 6298699 104118136 ZINC96302141 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 50952179 OC(=O)c1cc(C(O)=O)c(cc1C(O)=O)C(=O)N(Cc1cccc(Oc2ccccc2)c1)[C@H]1CCCc2ccccc12 InChI=1S/C33H27NO8/c35-30(25-17-27(32(38)39)28(33(40)41)18-26(25)31(36)37)34(29-15-7-10-21-9-4-5-14-24(21)29)19-20-8-6-13-23(16-20)42-22-11-2-1-3-12-22/h1-6,8-9,11-14,16-18,29H,7,10,15,19H2,(H,36,37)(H,38,39)(H,40,41)/t29-/m0/s1 VQGBOYBIENNKMI-LJAQVGFWSA-N 86478 A-317491 P2X purinoceptor 3 Homo sapiens 92 ChEMBL 10.1016/j.bmcl.2017.04.060 10.7270/Q2W95CP6 29805055 Tobinaga, H; Kameyama, T; Oohara, M; Kobayashi, N; Ohdan, M; Ishizuka, N; Kume, M; Tomari, M; Tanaka, Y; Takahashi, F; Kinoshita, H; Shimada, S; Shinohara, S; Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86478 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86478&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 71C 5SVR 9829395 136352527 4115 ZINC03990058 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 50952180 COc1ccc(cc1)C(=O)C1=C(O)C(=O)N(C1C1CCCCC1)c1ccc(cc1)-c1nnc(C)o1 InChI=1S/C27H27N3O5/c1-16-28-29-26(35-16)19-8-12-20(13-9-19)30-23(17-6-4-3-5-7-17)22(25(32)27(30)33)24(31)18-10-14-21(34-2)15-11-18/h8-15,17,23,32H,3-7H2,1-2H3 VHAFUJLBDMJJRI-UHFFFAOYSA-N 50274322 CHEMBL4126038 P2X purinoceptor 3 Homo sapiens 72 ChEMBL 10.1016/j.bmcl.2017.04.060 10.7270/Q2W95CP6 29805055 Tobinaga, H; Kameyama, T; Oohara, M; Kobayashi, N; Ohdan, M; Ishizuka, N; Kume, M; Tomari, M; Tanaka, Y; Takahashi, F; Kinoshita, H; Shimada, S; Shinohara, S; Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50274322 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50274322&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 145953759 104118137 ZINC96302142 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 50952181 COc1ccc(cc1)C(=O)C1=C(O)C(=O)N(C1c1ccc(F)cc1)c1ccc(cc1)C(F)(F)F InChI=1S/C25H17F4NO4/c1-34-19-12-4-15(5-13-19)22(31)20-21(14-2-8-17(26)9-3-14)30(24(33)23(20)32)18-10-6-16(7-11-18)25(27,28)29/h2-13,21,32H,1H3 QTZZYSRCOLIWLL-UHFFFAOYSA-N 50274323 CHEMBL4127171 P2X purinoceptor 3 Homo sapiens 360 ChEMBL 10.1016/j.bmcl.2017.04.060 10.7270/Q2W95CP6 29805055 Tobinaga, H; Kameyama, T; Oohara, M; Kobayashi, N; Ohdan, M; Ishizuka, N; Kume, M; Tomari, M; Tanaka, Y; Takahashi, F; Kinoshita, H; Shimada, S; Shinohara, S; Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50274323 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50274323&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 108679493 104118138 ZINC96302143 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 50952182 COc1ccc(cc1)C(=O)C1=C(O)C(=O)N(C1c1ccccc1)c1ccccc1 InChI=1S/C24H19NO4/c1-29-19-14-12-17(13-15-19)22(26)20-21(16-8-4-2-5-9-16)25(24(28)23(20)27)18-10-6-3-7-11-18/h2-15,21,27H,1H3 XMYCVURDSVPWAD-UHFFFAOYSA-N 50274324 CHEMBL4129722 P2X purinoceptor 3 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2017.04.060 10.7270/Q2W95CP6 29805055 Tobinaga, H; Kameyama, T; Oohara, M; Kobayashi, N; Ohdan, M; Ishizuka, N; Kume, M; Tomari, M; Tanaka, Y; Takahashi, F; Kinoshita, H; Shimada, S; Shinohara, S; Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50274324 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50274324&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 5922935 104118139 ZINC96302144 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 50952183 CCOC(=O)c1ccc(cc1)N1C(C(=CC1=O)C(=O)c1ccc(OC)cc1)c1ccccc1 InChI=1S/C27H23NO5/c1-3-33-27(31)20-9-13-21(14-10-20)28-24(29)17-23(25(28)18-7-5-4-6-8-18)26(30)19-11-15-22(32-2)16-12-19/h4-17,25H,3H2,1-2H3 RJJCCENEVZBSSE-UHFFFAOYSA-N 50274327 CHEMBL4126976 P2X purinoceptor 3 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2017.04.060 10.7270/Q2W95CP6 29805055 Tobinaga, H; Kameyama, T; Oohara, M; Kobayashi, N; Ohdan, M; Ishizuka, N; Kume, M; Tomari, M; Tanaka, Y; Takahashi, F; Kinoshita, H; Shimada, S; Shinohara, S; Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50274327 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50274327&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58044933 104118142 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 50952184 CCOC(=O)c1ccc(cc1)N1C(C(Cc2ccc(OC)cc2)=C(O)C1=O)c1ccccc1 InChI=1S/C27H25NO5/c1-3-33-27(31)20-11-13-21(14-12-20)28-24(19-7-5-4-6-8-19)23(25(29)26(28)30)17-18-9-15-22(32-2)16-10-18/h4-16,24,29H,3,17H2,1-2H3 JKCASUHOLPRBQR-UHFFFAOYSA-N 50274342 CHEMBL4129182 P2X purinoceptor 3 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2017.04.060 10.7270/Q2W95CP6 29805055 Tobinaga, H; Kameyama, T; Oohara, M; Kobayashi, N; Ohdan, M; Ishizuka, N; Kume, M; Tomari, M; Tanaka, Y; Takahashi, F; Kinoshita, H; Shimada, S; Shinohara, S; Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50274342 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50274342&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58045273 405256869 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 50952185 CCOC(=O)c1ccc(cc1)N1C(C(C(C)=O)=C(O)C1=O)c1ccccc1 InChI=1S/C21H19NO5/c1-3-27-21(26)15-9-11-16(12-10-15)22-18(14-7-5-4-6-8-14)17(13(2)23)19(24)20(22)25/h4-12,18,24H,3H2,1-2H3 CVQPUZPHCUWVPS-UHFFFAOYSA-N 50274343 CHEMBL1456917 P2X purinoceptor 3 Homo sapiens 4790 ChEMBL 10.1016/j.bmcl.2017.04.060 10.7270/Q2W95CP6 29805055 Tobinaga, H; Kameyama, T; Oohara, M; Kobayashi, N; Ohdan, M; Ishizuka, N; Kume, M; Tomari, M; Tanaka, Y; Takahashi, F; Kinoshita, H; Shimada, S; Shinohara, S; Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50274343 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50274343&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 3119320 405256870 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 50952186 CCOC(=O)c1ccc(cc1)N1C(C2CCCCC2)C(C(=O)c2ccc(OC)cc2)=C(O)C1=O InChI=1S/C27H29NO6/c1-3-34-27(32)19-9-13-20(14-10-19)28-23(17-7-5-4-6-8-17)22(25(30)26(28)31)24(29)18-11-15-21(33-2)16-12-18/h9-17,23,30H,3-8H2,1-2H3 AIGJETXQUZWZQA-UHFFFAOYSA-N 50274344 CHEMBL4129184 P2X purinoceptor 3 Homo sapiens 10.0 ChEMBL 10.1016/j.bmcl.2017.04.060 10.7270/Q2W95CP6 29805055 Tobinaga, H; Kameyama, T; Oohara, M; Kobayashi, N; Ohdan, M; Ishizuka, N; Kume, M; Tomari, M; Tanaka, Y; Takahashi, F; Kinoshita, H; Shimada, S; Shinohara, S; Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50274344 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50274344&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 145963681 405256871 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 50952187 CCOC(=O)c1ccc(cc1)N1C(C(C(=O)c2ccc(OC)cc2)=C(O)C1=O)c1ccccc1 InChI=1S/C27H23NO6/c1-3-34-27(32)19-9-13-20(14-10-19)28-23(17-7-5-4-6-8-17)22(25(30)26(28)31)24(29)18-11-15-21(33-2)16-12-18/h4-16,23,30H,3H2,1-2H3 XYPZYJIUWYCFNP-UHFFFAOYSA-N 50274345 CHEMBL4130242 P2X purinoceptor 3 Homo sapiens 20 ChEMBL 10.1016/j.bmcl.2017.04.060 10.7270/Q2W95CP6 29805055 Tobinaga, H; Kameyama, T; Oohara, M; Kobayashi, N; Ohdan, M; Ishizuka, N; Kume, M; Tomari, M; Tanaka, Y; Takahashi, F; Kinoshita, H; Shimada, S; Shinohara, S; Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50274345 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50274345&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 5796006 405256872 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 50952188 COc1ccc(cc1)C(=O)C1=C(O)C(=O)N(C1C1CCCCC1)c1ccc(cc1)-c1noc(C)n1 InChI=1S/C27H27N3O5/c1-16-28-26(29-35-16)19-8-12-20(13-9-19)30-23(17-6-4-3-5-7-17)22(25(32)27(30)33)24(31)18-10-14-21(34-2)15-11-18/h8-15,17,23,32H,3-7H2,1-2H3 SPSSLKGDQDCQRE-UHFFFAOYSA-N 50274346 CHEMBL4129491 P2X purinoceptor 3 Homo sapiens 19 ChEMBL 10.1016/j.bmcl.2017.04.060 10.7270/Q2W95CP6 29805055 Tobinaga, H; Kameyama, T; Oohara, M; Kobayashi, N; Ohdan, M; Ishizuka, N; Kume, M; Tomari, M; Tanaka, Y; Takahashi, F; Kinoshita, H; Shimada, S; Shinohara, S; Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50274346 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50274346&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 145953538 405256873 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 50952189 CCOC(=O)c1ccc(cc1)N1C(C(C(=O)Nc2ccc(OC)cc2)=C(O)C1=O)c1ccccc1 InChI=1S/C27H24N2O6/c1-3-35-27(33)18-9-13-20(14-10-18)29-23(17-7-5-4-6-8-17)22(24(30)26(29)32)25(31)28-19-11-15-21(34-2)16-12-19/h4-16,23,30H,3H2,1-2H3,(H,28,31) TVFVXHAKQQIFNJ-UHFFFAOYSA-N 50274362 CHEMBL4128222 P2X purinoceptor 3 Homo sapiens 3930 ChEMBL 10.1016/j.bmcl.2017.04.060 10.7270/Q2W95CP6 29805055 Tobinaga, H; Kameyama, T; Oohara, M; Kobayashi, N; Ohdan, M; Ishizuka, N; Kume, M; Tomari, M; Tanaka, Y; Takahashi, F; Kinoshita, H; Shimada, S; Shinohara, S; Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50274362 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50274362&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 145953535 405256874 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 50952190 CCOC(=O)c1ccc(cc1)N1C(C(C(=O)c2ccc(OC)cc2)=C(O)C1=O)c1ccc(Cl)cc1 InChI=1S/C27H22ClNO6/c1-3-35-27(33)18-6-12-20(13-7-18)29-23(16-4-10-19(28)11-5-16)22(25(31)26(29)32)24(30)17-8-14-21(34-2)15-9-17/h4-15,23,31H,3H2,1-2H3 RGGPASSYMGEWMZ-UHFFFAOYSA-N 50274363 CHEMBL4127788 P2X purinoceptor 3 Homo sapiens 130 ChEMBL 10.1016/j.bmcl.2017.04.060 10.7270/Q2W95CP6 29805055 Tobinaga, H; Kameyama, T; Oohara, M; Kobayashi, N; Ohdan, M; Ishizuka, N; Kume, M; Tomari, M; Tanaka, Y; Takahashi, F; Kinoshita, H; Shimada, S; Shinohara, S; Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50274363 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50274363&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 5935932 405256875 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 50952196 COc1ccc(cc1)C(=O)C1=C(O)C(=O)N(C1C1CCCCC1)c1ccc(cc1)-c1ccon1 InChI=1S/C27H26N2O5/c1-33-21-13-9-19(10-14-21)25(30)23-24(18-5-3-2-4-6-18)29(27(32)26(23)31)20-11-7-17(8-12-20)22-15-16-34-28-22/h7-16,18,24,31H,2-6H2,1H3 VVVNQMHFXWAMBD-UHFFFAOYSA-N 50274365 CHEMBL4127637 P2X purinoceptor 3 Homo sapiens 25 ChEMBL 10.1016/j.bmcl.2017.04.060 10.7270/Q2W95CP6 29805055 Tobinaga, H; Kameyama, T; Oohara, M; Kobayashi, N; Ohdan, M; Ishizuka, N; Kume, M; Tomari, M; Tanaka, Y; Takahashi, F; Kinoshita, H; Shimada, S; Shinohara, S; Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50274365 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50274365&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 145960885 405256876 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 50952197 COc1ccc(cc1)C(=O)C1=C(O)C(=O)N(C1C1CCCCC1)c1ccc(cc1)-c1cc(C)no1 InChI=1S/C28H28N2O5/c1-17-16-23(35-29-17)18-8-12-21(13-9-18)30-25(19-6-4-3-5-7-19)24(27(32)28(30)33)26(31)20-10-14-22(34-2)15-11-20/h8-16,19,25,32H,3-7H2,1-2H3 QYIBXRYVFACQBM-UHFFFAOYSA-N 50274369 CHEMBL4126267 P2X purinoceptor 3 Homo sapiens 9.0 ChEMBL 10.1016/j.bmcl.2017.04.060 10.7270/Q2W95CP6 29805055 Tobinaga, H; Kameyama, T; Oohara, M; Kobayashi, N; Ohdan, M; Ishizuka, N; Kume, M; Tomari, M; Tanaka, Y; Takahashi, F; Kinoshita, H; Shimada, S; Shinohara, S; Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50274369 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50274369&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 145954711 405256877 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 50952198 COc1ccc(cc1)C(=O)C1=C(O)C(=O)N(C1C1CCCCC1)c1ccc(cc1)-c1ncco1 InChI=1S/C27H26N2O5/c1-33-21-13-9-18(10-14-21)24(30)22-23(17-5-3-2-4-6-17)29(27(32)25(22)31)20-11-7-19(8-12-20)26-28-15-16-34-26/h7-17,23,31H,2-6H2,1H3 NHQWHJDXOGMFOF-UHFFFAOYSA-N 50274370 CHEMBL4129357 P2X purinoceptor 3 Homo sapiens 135 ChEMBL 10.1016/j.bmcl.2017.04.060 10.7270/Q2W95CP6 29805055 Tobinaga, H; Kameyama, T; Oohara, M; Kobayashi, N; Ohdan, M; Ishizuka, N; Kume, M; Tomari, M; Tanaka, Y; Takahashi, F; Kinoshita, H; Shimada, S; Shinohara, S; Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50274370 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50274370&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 145963480 405256878 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 50952199 COc1ccc(cc1)C(=O)C1=C(O)C(=O)N(C1C1CCCCC1)c1ccc(cc1)-c1nc(C)no1 InChI=1S/C27H27N3O5/c1-16-28-26(35-29-16)19-8-12-20(13-9-19)30-23(17-6-4-3-5-7-17)22(25(32)27(30)33)24(31)18-10-14-21(34-2)15-11-18/h8-15,17,23,32H,3-7H2,1-2H3 BTYJTFKUZIVXIR-UHFFFAOYSA-N 50274371 CHEMBL4128106 P2X purinoceptor 3 Homo sapiens 21 ChEMBL 10.1016/j.bmcl.2017.04.060 10.7270/Q2W95CP6 29805055 Tobinaga, H; Kameyama, T; Oohara, M; Kobayashi, N; Ohdan, M; Ishizuka, N; Kume, M; Tomari, M; Tanaka, Y; Takahashi, F; Kinoshita, H; Shimada, S; Shinohara, S; Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50274371 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50274371&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 145952869 405256879 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 50952200 COc1ccc(cc1)C(=O)C1=C(O)C(=O)N(C1c1ccccc1)c1ccc(cc1)-c1noc(C)n1 InChI=1S/C27H21N3O5/c1-16-28-26(29-35-16)19-8-12-20(13-9-19)30-23(17-6-4-3-5-7-17)22(25(32)27(30)33)24(31)18-10-14-21(34-2)15-11-18/h3-15,23,32H,1-2H3 YBDNVECAHHTEFH-UHFFFAOYSA-N 50274372 CHEMBL4127133 P2X purinoceptor 3 Homo sapiens 100 ChEMBL 10.1016/j.bmcl.2017.04.060 10.7270/Q2W95CP6 29805055 Tobinaga, H; Kameyama, T; Oohara, M; Kobayashi, N; Ohdan, M; Ishizuka, N; Kume, M; Tomari, M; Tanaka, Y; Takahashi, F; Kinoshita, H; Shimada, S; Shinohara, S; Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50274372 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50274372&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 145953533 405256880 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 50952201 COc1ccc(cc1)C(=O)C1=C(O)C(=O)N(C1c1ccccc1)c1ccc(CO)cc1 InChI=1S/C25H21NO5/c1-31-20-13-9-18(10-14-20)23(28)21-22(17-5-3-2-4-6-17)26(25(30)24(21)29)19-11-7-16(15-27)8-12-19/h2-14,22,27,29H,15H2,1H3 UQDDVQKRFRBKKF-UHFFFAOYSA-N 50274374 CHEMBL4128559 P2X purinoceptor 3 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2017.04.060 10.7270/Q2W95CP6 29805055 Tobinaga, H; Kameyama, T; Oohara, M; Kobayashi, N; Ohdan, M; Ishizuka, N; Kume, M; Tomari, M; Tanaka, Y; Takahashi, F; Kinoshita, H; Shimada, S; Shinohara, S; Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50274374 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50274374&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 145960696 405256881 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 50952202 COc1ccc(cc1)C(=O)C1=C(O)C(=O)N(C1c1ccccc1)c1ccc(cc1)C(=O)N(C)C InChI=1S/C27H24N2O5/c1-28(2)26(32)19-9-13-20(14-10-19)29-23(17-7-5-4-6-8-17)22(25(31)27(29)33)24(30)18-11-15-21(34-3)16-12-18/h4-16,23,31H,1-3H3 LAMZIMAABVNXEM-UHFFFAOYSA-N 50274375 CHEMBL4128051 P2X purinoceptor 3 Homo sapiens 5920 ChEMBL 10.1016/j.bmcl.2017.04.060 10.7270/Q2W95CP6 29805055 Tobinaga, H; Kameyama, T; Oohara, M; Kobayashi, N; Ohdan, M; Ishizuka, N; Kume, M; Tomari, M; Tanaka, Y; Takahashi, F; Kinoshita, H; Shimada, S; Shinohara, S; Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50274375 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50274375&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 145963223 405256882 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 50952203 COc1ccc(cc1)C(=O)C1=C(O)C(=O)N(C1c1ccccc1)c1ccc(cc1)C(C)=O InChI=1S/C26H21NO5/c1-16(28)17-8-12-20(13-9-17)27-23(18-6-4-3-5-7-18)22(25(30)26(27)31)24(29)19-10-14-21(32-2)15-11-19/h3-15,23,30H,1-2H3 PAXQHRDGSDEBOF-UHFFFAOYSA-N 50274376 CHEMBL4129638 P2X purinoceptor 3 Homo sapiens 3280 ChEMBL 10.1016/j.bmcl.2017.04.060 10.7270/Q2W95CP6 29805055 Tobinaga, H; Kameyama, T; Oohara, M; Kobayashi, N; Ohdan, M; Ishizuka, N; Kume, M; Tomari, M; Tanaka, Y; Takahashi, F; Kinoshita, H; Shimada, S; Shinohara, S; Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50274376 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50274376&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 145963490 405256883 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 50952204 COc1ccc(cc1)C(=O)C1=C(O)C(=O)N(C1c1ccccc1)c1ccc(cc1)C(O)=O InChI=1S/C25H19NO6/c1-32-19-13-9-16(10-14-19)22(27)20-21(15-5-3-2-4-6-15)26(24(29)23(20)28)18-11-7-17(8-12-18)25(30)31/h2-14,21,28H,1H3,(H,30,31) IPEKPYCGZGSYKI-UHFFFAOYSA-N 50274377 CHEMBL4126198 P2X purinoceptor 3 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2017.04.060 10.7270/Q2W95CP6 29805055 Tobinaga, H; Kameyama, T; Oohara, M; Kobayashi, N; Ohdan, M; Ishizuka, N; Kume, M; Tomari, M; Tanaka, Y; Takahashi, F; Kinoshita, H; Shimada, S; Shinohara, S; Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50274377 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50274377&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 5891789 405256884 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 50952205 CCOC(=O)c1ccc(cc1)N1C(C(C(=O)c2ccc(OC)cc2)=C(NO)C1=O)c1ccccc1 InChI=1S/C27H24N2O6/c1-3-35-27(32)19-9-13-20(14-10-19)29-24(17-7-5-4-6-8-17)22(23(28-33)26(29)31)25(30)18-11-15-21(34-2)16-12-18/h4-16,24,28,33H,3H2,1-2H3 OJQAQTJFYFNSMI-UHFFFAOYSA-N 50274378 CHEMBL4127573 P2X purinoceptor 3 Homo sapiens 4240 ChEMBL 10.1016/j.bmcl.2017.04.060 10.7270/Q2W95CP6 29805055 Tobinaga, H; Kameyama, T; Oohara, M; Kobayashi, N; Ohdan, M; Ishizuka, N; Kume, M; Tomari, M; Tanaka, Y; Takahashi, F; Kinoshita, H; Shimada, S; Shinohara, S; Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50274378 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50274378&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 145954945 405256885 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 50952206 CCOC(=O)c1ccc(cc1)N1C(C(C(=O)c2ccc(OC)cc2)=C(OC)C1=O)c1ccccc1 InChI=1S/C28H25NO6/c1-4-35-28(32)20-10-14-21(15-11-20)29-24(18-8-6-5-7-9-18)23(26(34-3)27(29)31)25(30)19-12-16-22(33-2)17-13-19/h5-17,24H,4H2,1-3H3 SFQAMBUHVUOILN-UHFFFAOYSA-N 50274379 CHEMBL4129448 P2X purinoceptor 3 Homo sapiens 9800 ChEMBL 10.1016/j.bmcl.2017.04.060 10.7270/Q2W95CP6 29805055 Tobinaga, H; Kameyama, T; Oohara, M; Kobayashi, N; Ohdan, M; Ishizuka, N; Kume, M; Tomari, M; Tanaka, Y; Takahashi, F; Kinoshita, H; Shimada, S; Shinohara, S; Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50274379 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50274379&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 145953319 405256886 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 50952207 CCOC(=O)c1ccc(cc1)N1C(C(NC(=O)c2ccc(OC)cc2)=C(O)C1=O)c1ccccc1 InChI=1S/C27H24N2O6/c1-3-35-27(33)19-9-13-20(14-10-19)29-23(17-7-5-4-6-8-17)22(24(30)26(29)32)28-25(31)18-11-15-21(34-2)16-12-18/h4-16,23,30H,3H2,1-2H3,(H,28,31) LTIJFIZCRLQXMJ-UHFFFAOYSA-N 50274380 CHEMBL4126274 P2X purinoceptor 3 Homo sapiens 1370 ChEMBL 10.1016/j.bmcl.2017.04.060 10.7270/Q2W95CP6 29805055 Tobinaga, H; Kameyama, T; Oohara, M; Kobayashi, N; Ohdan, M; Ishizuka, N; Kume, M; Tomari, M; Tanaka, Y; Takahashi, F; Kinoshita, H; Shimada, S; Shinohara, S; Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50274380 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50274380&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 145954942 405256887 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 50952208 CCOC(=O)c1ccc(cc1)N1C(C(\C(=N\O)c2ccc(OC)cc2)=C(O)C1=O)c1ccccc1 InChI=1S/C27H24N2O6/c1-3-35-27(32)19-9-13-20(14-10-19)29-24(18-7-5-4-6-8-18)22(25(30)26(29)31)23(28-33)17-11-15-21(34-2)16-12-17/h4-16,24,30,33H,3H2,1-2H3/b28-23+ IRTXRGLPEHQBFJ-WEMUOSSPSA-N 50274381 CHEMBL4127905 P2X purinoceptor 3 Homo sapiens 560 ChEMBL 10.1016/j.bmcl.2017.04.060 10.7270/Q2W95CP6 29805055 Tobinaga, H; Kameyama, T; Oohara, M; Kobayashi, N; Ohdan, M; Ishizuka, N; Kume, M; Tomari, M; Tanaka, Y; Takahashi, F; Kinoshita, H; Shimada, S; Shinohara, S; Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50274381 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50274381&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 145956116 405256888 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 50952209 CCOC(=O)c1ccc(cc1)N1C(C(=C(O)C1=O)c1ccc(OC)cc1)c1ccccc1 InChI=1S/C26H23NO5/c1-3-32-26(30)19-9-13-20(14-10-19)27-23(18-7-5-4-6-8-18)22(24(28)25(27)29)17-11-15-21(31-2)16-12-17/h4-16,23,28H,3H2,1-2H3 OQPZJZLAYAKCBU-UHFFFAOYSA-N 50274382 CHEMBL4128476 P2X purinoceptor 3 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2017.04.060 10.7270/Q2W95CP6 29805055 Tobinaga, H; Kameyama, T; Oohara, M; Kobayashi, N; Ohdan, M; Ishizuka, N; Kume, M; Tomari, M; Tanaka, Y; Takahashi, F; Kinoshita, H; Shimada, S; Shinohara, S; Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50274382 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50274382&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 145961319 405256889 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 50952210 CCOC(=O)c1ccc(cc1)N1C(C(C(=O)C(C)(C)C)=C(O)C1=O)c1ccccc1 InChI=1S/C24H25NO5/c1-5-30-23(29)16-11-13-17(14-12-16)25-19(15-9-7-6-8-10-15)18(20(26)22(25)28)21(27)24(2,3)4/h6-14,19,26H,5H2,1-4H3 UWDGROJDEXNLBM-UHFFFAOYSA-N 50274396 CHEMBL4130133 P2X purinoceptor 3 Homo sapiens 260 ChEMBL 10.1016/j.bmcl.2017.04.060 10.7270/Q2W95CP6 29805055 Tobinaga, H; Kameyama, T; Oohara, M; Kobayashi, N; Ohdan, M; Ishizuka, N; Kume, M; Tomari, M; Tanaka, Y; Takahashi, F; Kinoshita, H; Shimada, S; Shinohara, S; Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50274396 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50274396&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 25097734 405256890 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 50952211 CCCCC(=O)C1=C(O)C(=O)N(C1c1ccccc1)c1ccc(cc1)C(=O)OCC InChI=1S/C24H25NO5/c1-3-5-11-19(26)20-21(16-9-7-6-8-10-16)25(23(28)22(20)27)18-14-12-17(13-15-18)24(29)30-4-2/h6-10,12-15,21,27H,3-5,11H2,1-2H3 MCFUOUZLUPZJBC-UHFFFAOYSA-N 50274397 CHEMBL4129705 P2X purinoceptor 3 Homo sapiens 1020 ChEMBL 10.1016/j.bmcl.2017.04.060 10.7270/Q2W95CP6 29805055 Tobinaga, H; Kameyama, T; Oohara, M; Kobayashi, N; Ohdan, M; Ishizuka, N; Kume, M; Tomari, M; Tanaka, Y; Takahashi, F; Kinoshita, H; Shimada, S; Shinohara, S; Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50274397 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50274397&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58045279 405256891 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 50952212 CCOC(=O)c1ccc(cc1)N1CC(C(=O)c2ccc(OC)cc2)=C(O)C1=O InChI=1S/C21H19NO6/c1-3-28-21(26)14-4-8-15(9-5-14)22-12-17(19(24)20(22)25)18(23)13-6-10-16(27-2)11-7-13/h4-11,24H,3,12H2,1-2H3 FWYZKWKOUCUIDN-UHFFFAOYSA-N 50274398 CHEMBL4125741 P2X purinoceptor 3 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2017.04.060 10.7270/Q2W95CP6 29805055 Tobinaga, H; Kameyama, T; Oohara, M; Kobayashi, N; Ohdan, M; Ishizuka, N; Kume, M; Tomari, M; Tanaka, Y; Takahashi, F; Kinoshita, H; Shimada, S; Shinohara, S; Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50274398 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50274398&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 145962500 405256892 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 50952213 CCOC(=O)c1ccc(cc1)N1C(C(C)C)C(C(=O)c2ccc(OC)cc2)=C(O)C1=O InChI=1S/C24H25NO6/c1-5-31-24(29)16-6-10-17(11-7-16)25-20(14(2)3)19(22(27)23(25)28)21(26)15-8-12-18(30-4)13-9-15/h6-14,20,27H,5H2,1-4H3 IYCZOMGTSUJAMH-UHFFFAOYSA-N 50274399 CHEMBL4129031 P2X purinoceptor 3 Homo sapiens 140 ChEMBL 10.1016/j.bmcl.2017.04.060 10.7270/Q2W95CP6 29805055 Tobinaga, H; Kameyama, T; Oohara, M; Kobayashi, N; Ohdan, M; Ishizuka, N; Kume, M; Tomari, M; Tanaka, Y; Takahashi, F; Kinoshita, H; Shimada, S; Shinohara, S; Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50274399 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50274399&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 145961138 405256893 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 50952214 CCOC(=O)c1ccc(cc1)N1C(C(C(=O)c2ccc(OC)cc2)=C(O)C1=O)c1ccc(F)cc1 InChI=1S/C27H22FNO6/c1-3-35-27(33)18-6-12-20(13-7-18)29-23(16-4-10-19(28)11-5-16)22(25(31)26(29)32)24(30)17-8-14-21(34-2)15-9-17/h4-15,23,31H,3H2,1-2H3 VJPJYTGPDHUHPR-UHFFFAOYSA-N 50274400 CHEMBL4128213 P2X purinoceptor 3 Homo sapiens 20 ChEMBL 10.1016/j.bmcl.2017.04.060 10.7270/Q2W95CP6 29805055 Tobinaga, H; Kameyama, T; Oohara, M; Kobayashi, N; Ohdan, M; Ishizuka, N; Kume, M; Tomari, M; Tanaka, Y; Takahashi, F; Kinoshita, H; Shimada, S; Shinohara, S; Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50274400 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50274400&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 5936815 405256894 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 50952215 CCOC(=O)c1ccc(cc1)N1C(C(C(=O)c2ccc(OC)cc2)=C(O)C1=O)c1cccc(F)c1 InChI=1S/C27H22FNO6/c1-3-35-27(33)17-7-11-20(12-8-17)29-23(18-5-4-6-19(28)15-18)22(25(31)26(29)32)24(30)16-9-13-21(34-2)14-10-16/h4-15,23,31H,3H2,1-2H3 RDFJZGBXRMOGRW-UHFFFAOYSA-N 50274415 CHEMBL4126833 P2X purinoceptor 3 Homo sapiens 30 ChEMBL 10.1016/j.bmcl.2017.04.060 10.7270/Q2W95CP6 29805055 Tobinaga, H; Kameyama, T; Oohara, M; Kobayashi, N; Ohdan, M; Ishizuka, N; Kume, M; Tomari, M; Tanaka, Y; Takahashi, F; Kinoshita, H; Shimada, S; Shinohara, S; Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50274415 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50274415&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 5897666 405256895 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 50952216 CCOC(=O)c1ccc(cc1)N1C(C(C(=O)c2ccc(OC)cc2)=C(O)C1=O)c1ccccc1F InChI=1S/C27H22FNO6/c1-3-35-27(33)17-8-12-18(13-9-17)29-23(20-6-4-5-7-21(20)28)22(25(31)26(29)32)24(30)16-10-14-19(34-2)15-11-16/h4-15,23,31H,3H2,1-2H3 FARMIPUSBZICOF-UHFFFAOYSA-N 50274416 CHEMBL4126971 P2X purinoceptor 3 Homo sapiens 130 ChEMBL 10.1016/j.bmcl.2017.04.060 10.7270/Q2W95CP6 29805055 Tobinaga, H; Kameyama, T; Oohara, M; Kobayashi, N; Ohdan, M; Ishizuka, N; Kume, M; Tomari, M; Tanaka, Y; Takahashi, F; Kinoshita, H; Shimada, S; Shinohara, S; Kai, H Shionogi & Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50274416 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50274416&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 5861195 405256896 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51124091 C[C@@H](NC(=O)c1cc(cc(c1)C(C)(C)O)-c1ccc(Cl)cn1)c1ccc([n+]([O-])c1)C(F)(F)F InChI=1S/C23H21ClF3N3O3/c1-13(14-4-7-20(23(25,26)27)30(33)12-14)29-21(31)16-8-15(9-17(10-16)22(2,3)32)19-6-5-18(24)11-28-19/h4-13,32H,1-3H3,(H,29,31)/t13-/m1/s1 KVJDENFESRCAQM-CYBMUJFWSA-N 50460861 CHEMBL4229237 P2X purinoceptor 3 Homo sapiens 18 ChEMBL 10.1016/j.bmcl.2018.02.039 10.7270/Q25T3P36 29548573 Ginnetti, AT; Paone, DV; Stauffer, SR; Potteiger, CM; Shaw, AW; Deng, J; Mulhearn, JJ; Nguyen, DN; Segerdell, C; Anquandah, J; Calamari, A; Cheng, G; Leitl, MD; Liang, A; Moore, E; Panigel, J; Urban, M; Wang, J; Fillgrove, K; Tang, C; Cook, S; Kane, S; Salvatore, CA; Graham, SL; Burgey, CS Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50460861 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50460861&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 42603033 433928126 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51124099 C[C@@H](NC(=O)c1cc(cc(c1)-c1ccc(C)cn1)C1=NO[C@@H](C1)c1ccccn1)c1ccc(F)cn1 InChI=1S/C28H24FN5O2/c1-17-6-8-24(31-15-17)19-11-20(26-14-27(36-34-26)25-5-3-4-10-30-25)13-21(12-19)28(35)33-18(2)23-9-7-22(29)16-32-23/h3-13,15-16,18,27H,14H2,1-2H3,(H,33,35)/t18-,27+/m1/s1 SUXRXYKUAHNUAX-CLYVBNDRSA-N 50460863 CHEMBL4227228 P2X purinoceptor 3 Homo sapiens 24 ChEMBL 10.1016/j.bmcl.2018.02.039 10.7270/Q25T3P36 29548573 Ginnetti, AT; Paone, DV; Stauffer, SR; Potteiger, CM; Shaw, AW; Deng, J; Mulhearn, JJ; Nguyen, DN; Segerdell, C; Anquandah, J; Calamari, A; Cheng, G; Leitl, MD; Liang, A; Moore, E; Panigel, J; Urban, M; Wang, J; Fillgrove, K; Tang, C; Cook, S; Kane, S; Salvatore, CA; Graham, SL; Burgey, CS Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50460863 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50460863&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 66895517 433928128 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51100082 [Na+].[Na+].[Na+].[Na+].[O-]S(=O)(=O)c1ccc(NC(=O)c2cc(NC(=O)Nc3cc(cc(c3)C(=O)Nc3ccc(cc3)S([O-])(=O)=O)C(=O)Nc3ccc(cc3)S([O-])(=O)=O)cc(c2)C(=O)Nc2ccc(cc2)S([O-])(=O)=O)cc1 InChI=1S/C41H32N6O17S4/c48-37(42-27-1-9-33(10-2-27)65(53,54)55)23-17-24(38(49)43-28-3-11-34(12-4-28)66(56,57)58)20-31(19-23)46-41(52)47-32-21-25(39(50)44-29-5-13-35(14-6-29)67(59,60)61)18-26(22-32)40(51)45-30-7-15-36(16-8-30)68(62,63)64/h1-22H,(H,42,48)(H,43,49)(H,44,50)(H,45,51)(H2,46,47,52)(H,53,54,55)(H,56,57,58)(H,59,60,61)(H,62,63,64)/p-4 XLJCHJYKCSKQLL-UHFFFAOYSA-J 50370297 CHEMBL4160315 P2X purinoceptor 3 Homo sapiens 1600 ChEMBL 10.1016/j.ejmech.2018.03.023 10.7270/Q2S75JWB 29649742 Kwak, SH; Shin, S; Lee, JH; Shim, JK; Kim, M; Lee, SD; Lee, A; Bae, J; Park, JH; Abdelrahman, A; Müller, CE; Cho, SK; Kang, SG; Bae, MA; Yang, JY; Ko, H; Goddard, WA; Kim, YC Gwangju Institute of Science and Technology (GIST) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50370297 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50370297&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 16066783 160849399 ZINC48998601 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51100106 COc1ccc(cc1)-c1ccc2c(NC(=O)CC34CC5CC(CC(C5)C3)C4)cccc2n1 InChI=1S/C28H30N2O2/c1-32-22-7-5-21(6-8-22)24-10-9-23-25(29-24)3-2-4-26(23)30-27(31)17-28-14-18-11-19(15-28)13-20(12-18)16-28/h2-10,18-20H,11-17H2,1H3,(H,30,31) PHFCELLDNIZFRA-UHFFFAOYSA-N 50370238 CHEMBL4159276 P2X purinoceptor 3 Homo sapiens 3000 ChEMBL 10.1016/j.ejmech.2018.03.023 10.7270/Q2S75JWB 29649742 Kwak, SH; Shin, S; Lee, JH; Shim, JK; Kim, M; Lee, SD; Lee, A; Bae, J; Park, JH; Abdelrahman, A; Müller, CE; Cho, SK; Kang, SG; Bae, MA; Yang, JY; Ko, H; Goddard, WA; Kim, YC Gwangju Institute of Science and Technology (GIST) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50370238 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50370238&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 145959607 160849340 ZINC27091716 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51100107 CC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C InChI=1S/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19H,4-11H2,1-3H3/t16-,17+,18-,19-,20-,21+/m0/s1 RJKFOVLPORLFTN-LEKSSAKUSA-N 8903 (1S,2R,10S,11S,14S,15S)-14-acetyl-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-en-5-one::CHEMBL103::progesterone P2X purinoceptor 3 Homo sapiens 1600 ChEMBL 10.1016/j.ejmech.2018.03.023 10.7270/Q2S75JWB 29649742 Kwak, SH; Shin, S; Lee, JH; Shim, JK; Kim, M; Lee, SD; Lee, A; Bae, J; Park, JH; Abdelrahman, A; Müller, CE; Cho, SK; Kang, SG; Bae, MA; Yang, JY; Ko, H; Goddard, WA; Kim, YC Gwangju Institute of Science and Technology (GIST) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=8903 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=8903&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search STR 1W0F,5MLM,4J6C,5LUR,1YA3,2HZQ,6HGK,1H60,1DBB,1MRQ,6GSD,4FN9,1A28,2ABA,4LTW,6F8C,4L1X,4BB2,6F88,5A1P,5A1R,2AA5,2AA6,4Y8W,4L1W,7RAF,4NKX,3COT,2O5Y,4R21 5994 172097179 17026 CHEMBL103 DB00396 C00410 ZINC04428529 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843170 C[C@@H](NC(=O)c1cc(OC[C@H]2CN(C)CCO2)cc(c1)-c1ncc(C)s1)c1ccc(nc1)C(F)(F)F InChI=1S/C25H27F3N4O3S/c1-15-11-30-24(36-15)19-8-18(9-20(10-19)35-14-21-13-32(3)6-7-34-21)23(33)31-16(2)17-4-5-22(29-12-17)25(26,27)28/h4-5,8-12,16,21H,6-7,13-14H2,1-3H3,(H,31,33)/t16-,21-/m1/s1 PQZKBUDIGDWISA-IIBYNOLFSA-N 320199 3-{[(2R)-4-methylmorpholin-2-yl]methoxyl}-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[6-(trifluoromethyl)pyridin-3-yl]ethyl}benzamide::US10174016, Example 366::US10202369, Example 366::US10472354, Example 366 P2X purinoceptor 3 Homo sapiens 18.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320199 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320199&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397655 384223472 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843172 C[C@@H](NC(=O)c1cc(OC[C@H]2CN(C)CCO2)cc(c1)-c1ncc(Cl)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H23ClF3N5O3S/c1-13(16-8-29-22(30-9-16)23(25,26)27)31-20(33)14-5-15(21-28-10-19(24)36-21)7-17(6-14)35-12-18-11-32(2)3-4-34-18/h5-10,13,18H,3-4,11-12H2,1-2H3,(H,31,33)/t13-,18-/m1/s1 AJIHXKQJGQMCEX-FZKQIMNGSA-N 320200 3-(5-chloro- 1,3-thiazol-2- yl)-5-{[(2R)-4- methylmorpholin- 2-yl]methoxy}-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5-yl] ethyl}benzamide::US10174016, Example 367::US10202369, Example 367::US10472354, Example 367 P2X purinoceptor 3 Homo sapiens 13.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320200 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320200&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397149 384223473 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843174 CN1CCO[C@H](COc2cc(cc(c2)-c2ncc(C)s2)C(=O)NCc2cnc(nc2)C(F)(F)F)C1 InChI=1S/C23H24F3N5O3S/c1-14-8-28-21(35-14)17-5-16(6-18(7-17)34-13-19-12-31(2)3-4-33-19)20(32)27-9-15-10-29-22(30-11-15)23(24,25)26/h5-8,10-11,19H,3-4,9,12-13H2,1-2H3,(H,27,32)/t19-/m0/s1 VTYFKUULJMRVCQ-IBGZPJMESA-N 320201 3-{[(2S)-4- methylmorpholin- 2-yl]methoxy}-5- (5-methyl-1,3- thiazol-2-yl)- N-{[2- (trifluoromethyl) pyrimidin-5-yl] methyl} benzamide::US10174016, Example 368::US10202369, Example 368::US10472354, Example 368 P2X purinoceptor 3 Homo sapiens 84.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320201 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320201&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397462 384223474 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843176 C[C@@H](NC(=O)c1cc(OC[C@H]2CN(C)CCO2)cc(c1)-c1ncc(C)s1)c1ccc(nc1)C(F)F InChI=1S/C25H28F2N4O3S/c1-15-11-29-25(35-15)19-8-18(9-20(10-19)34-14-21-13-31(3)6-7-33-21)24(32)30-16(2)17-4-5-22(23(26)27)28-12-17/h4-5,8-12,16,21,23H,6-7,13-14H2,1-3H3,(H,30,32)/t16-,21-/m1/s1 YEIOEBIHIRXRPN-IIBYNOLFSA-N 320202 N-{(1R)-1-[6- (difluoromethyl) pyridin-3- yl]ethyl}-3- {[(2R)-4- methylmorpholin- 2-yl]methoxy}-5- (5-methyl-1,3- thiazol-2- yl)benzamide::US10174016, Example 369::US10202369, Example 369::US10472354, Example 369 P2X purinoceptor 3 Homo sapiens 11.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320202 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320202&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397220 384223475 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843178 C[C@@H](NC(=O)c1cc(OC[C@@H]2CN(C)CCO2)cc(c1)-c1ncc(C)s1)c1ccc(nc1)C(F)(F)F InChI=1S/C25H27F3N4O3S/c1-15-11-30-24(36-15)19-8-18(9-20(10-19)35-14-21-13-32(3)6-7-34-21)23(33)31-16(2)17-4-5-22(29-12-17)25(26,27)28/h4-5,8-12,16,21H,6-7,13-14H2,1-3H3,(H,31,33)/t16-,21+/m1/s1 PQZKBUDIGDWISA-IERDGZPVSA-N 320203 3-{[(2S)-4- methylmorpholin 2-yl]methoxy}-5- (5-methyl-1,3- thiazol-2-yl)- N-{(1R)-1-[6- (trifluoromethyl) pyridin-3- yl]ethyl} benzamide::US10174016, Example 370::US10202369, Example 370::US10472354, Example 370 P2X purinoceptor 3 Homo sapiens 41.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320203 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320203&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397778 384223476 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843180 C[C@@H](NC(=O)c1cc(OCC2(F)CN(C)C2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H23F4N5O2S/c1-13-7-28-20(35-13)16-4-15(5-18(6-16)34-12-22(24)10-32(3)11-22)19(33)31-14(2)17-8-29-21(30-9-17)23(25,26)27/h4-9,14H,10-12H2,1-3H3,(H,31,33)/t14-/m1/s1 UHPSIXSPUGVYFA-CQSZACIVSA-N 320204 3-[(3-fluoro-1- methylazetidin-3- yl}methoxy]-5- (5-methyl-1,3- thiazol-2-yl)- N-{(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 371::US10202369, Example 371::US10472354, Example 371 P2X purinoceptor 3 Homo sapiens 24.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320204 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320204&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397234 384223477 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843182 CN1CCO[C@@H](COc2cc(cc(c2)-c2ncc(C)s2)C(=O)NCc2cnc(nc2)C(F)(F)F)C1 InChI=1S/C23H24F3N5O3S/c1-14-8-28-21(35-14)17-5-16(6-18(7-17)34-13-19-12-31(2)3-4-33-19)20(32)27-9-15-10-29-22(30-11-15)23(24,25)26/h5-8,10-11,19H,3-4,9,12-13H2,1-2H3,(H,27,32)/t19-/m1/s1 VTYFKUULJMRVCQ-LJQANCHMSA-N 320205 3-{[(2R)-4- methylmorpholin- 2-yl]methoxy}-5- (5-methyl-1,3- thiazol-2-yl)- N-{[2- (trifluoromethyl) pyrimidin-5-yl] methyl} benzamide::US10174016, Example 372::US10202369, Example 372::US10472354, Example 372 P2X purinoceptor 3 Homo sapiens 19.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320205 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320205&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397797 384223478 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843184 C[C@@H](NC(=O)c1cc(OC[C@H]2CN(C)CCO2)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F InChI=1S/C24H26F3N5O3S/c1-14-11-28-23(36-14)17-8-16(9-18(10-17)35-13-19-12-32(3)6-7-34-19)22(33)29-15(2)20-4-5-21(31-30-20)24(25,26)27/h4-5,8-11,15,19H,6-7,12-13H2,1-3H3,(H,29,33)/t15-,19-/m1/s1 IJFKDPNABTXGCF-DNVCBOLYSA-N 320206 3-{[(2R)-4- methylmorpholin- 2-yl]methoxy}-5- (5-methyl-1,3- thiazol-2-yl)- N-{(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl} benzamide::US10174016, Example 373::US10202369, Example 373::US10472354, Example 373 P2X purinoceptor 3 Homo sapiens 21.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320206 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320206&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397505 384223479 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843186 C[C@@H](NC(=O)c1cc(OC[C@@H]2CN(C)CCO2)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F InChI=1S/C24H26F3N5O3S/c1-14-11-28-23(36-14)17-8-16(9-18(10-17)35-13-19-12-32(3)6-7-34-19)22(33)29-15(2)20-4-5-21(31-30-20)24(25,26)27/h4-5,8-11,15,19H,6-7,12-13H2,1-3H3,(H,29,33)/t15-,19+/m1/s1 IJFKDPNABTXGCF-BEFAXECRSA-N 320207 3-{[(2S)-4- methylmorpholin- 2-yl]methoxy}-5- (5-methyl-1,3- thiazol-2-yl)- N-{(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl} benzamide::US10174016, Example 374::US10202369, Example 374::US10472354, Example 374 P2X purinoceptor 3 Homo sapiens 55.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320207 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320207&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397406 384223480 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843188 CCc1cnc(s1)-c1cc(OC[C@@H]2CN(C)CCO2)cc(c1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C25H28F3N5O3S/c1-4-21-12-29-23(37-21)17-7-16(8-19(9-17)36-14-20-13-33(3)5-6-35-20)22(34)32-15(2)18-10-30-24(31-11-18)25(26,27)28/h7-12,15,20H,4-6,13-14H2,1-3H3,(H,32,34)/t15-,20+/m1/s1 PEGAFCGSQABLTK-QRWLVFNGSA-N 320208 3-(5-ethyl-1,3- thiazol-2-yl)-5- {[(2S)-4- methylmorpholin- 2- yl]methoxy}-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 375::US10202369, Example 375::US10472354, Example 375 P2X purinoceptor 3 Homo sapiens 11.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320208 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320208&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397736 384223481 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843190 C[C@@H](NC(=O)c1cc(OC[C@@H]2CN(C)CCO2)cc(c1)-c1ncc(Cl)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H23ClF3N5O3S/c1-13(16-8-29-22(30-9-16)23(25,26)27)31-20(33)14-5-15(21-28-10-19(24)36-21)7-17(6-14)35-12-18-11-32(2)3-4-34-18/h5-10,13,18H,3-4,11-12H2,1-2H3,(H,31,33)/t13-,18+/m1/s1 AJIHXKQJGQMCEX-ACJLOTCBSA-N 320209 3-(5-chloro- 1,3-thiazol-2- yl)-5-{[(2S)-4- methylmorpholin- 2-yl]methoxy}-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 376::US10202369, Example 376::US10472354, Example 376 P2X purinoceptor 3 Homo sapiens 32.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320209 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320209&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397674 384223482 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843192 CCc1cnc(s1)-c1cc(OC[C@H]2CN(C)CCO2)cc(c1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C25H28F3N5O3S/c1-4-21-12-29-23(37-21)17-7-16(8-19(9-17)36-14-20-13-33(3)5-6-35-20)22(34)32-15(2)18-10-30-24(31-11-18)25(26,27)28/h7-12,15,20H,4-6,13-14H2,1-3H3,(H,32,34)/t15-,20-/m1/s1 PEGAFCGSQABLTK-FOIQADDNSA-N 320210 3-(5-ethyl-1,3- thiazol-2-yl)-5- {[(2R)-4- methylmorpholin- 2-yl]methoxy}-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 377::US10202369, Example 377::US10472354, Example 377 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320210 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320210&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397144 384223483 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843194 C[C@@H](NC(=O)c1cc(OC[C@@H]2CCCN2C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H26F3N5O2S/c1-14-10-28-22(35-14)17-7-16(8-20(9-17)34-13-19-5-4-6-32(19)3)21(33)31-15(2)18-11-29-23(30-12-18)24(25,26)27/h7-12,15,19H,4-6,13H2,1-3H3,(H,31,33)/t15-,19+/m1/s1 TYUJHJGDOVFFQY-BEFAXECRSA-N 320211 3-{[(2S)-1- methylpyrrolidin- 2-yl]methoxy}-5- (5-methyl-1,3- thiazol-2-yl)- N-{(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 378::US10202369, Example 378::US10472354, Example 378 P2X purinoceptor 3 Homo sapiens 60.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320211 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320211&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397183 384223484 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843196 C[C@@H](NC(=O)c1cc(OC[C@H]2CCCN2C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H26F3N5O2S/c1-14-10-28-22(35-14)17-7-16(8-20(9-17)34-13-19-5-4-6-32(19)3)21(33)31-15(2)18-11-29-23(30-12-18)24(25,26)27/h7-12,15,19H,4-6,13H2,1-3H3,(H,31,33)/t15-,19-/m1/s1 TYUJHJGDOVFFQY-DNVCBOLYSA-N 320212 3-{[(2R)-1- methylpyrrolidin- 2-yl]methoxy}-5 (5-methyl-1,3- thiazol-2-yl)- N-{(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 379::US10202369, Example 379::US10472354, Example 379 P2X purinoceptor 3 Homo sapiens 42.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320212 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320212&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397315 384223485 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843198 C[C@@H](NC(=O)c1cc(OCC2CCN(C)CC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C25H28F3N5O2S/c1-15-11-29-23(36-15)19-8-18(9-21(10-19)35-14-17-4-6-33(3)7-5-17)22(34)32-16(2)20-12-30-24(31-13-20)25(26,27)28/h8-13,16-17H,4-7,14H2,1-3H3,(H,32,34)/t16-/m1/s1 GQMGTASPVLCRIR-MRXNPFEDSA-N 320213 3-[(1- methylpiperidin- 4-yl)methoxy]-5- (5-methyl-1,3- thiazol-2-yl)- N-{(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 380::US10202369, Example 380::US10472354, Example 380 P2X purinoceptor 3 Homo sapiens 32.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320213 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320213&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397264 384223486 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843200 CC(C)N1CCO[C@@H](COc2cc(cc(c2)-c2ncc(C)s2)C(=O)N[C@H](C)c2cnc(nc2)C(F)(F)F)C1 InChI=1S/C26H30F3N5O3S/c1-15(2)34-5-6-36-22(13-34)14-37-21-8-18(7-19(9-21)24-30-10-16(3)38-24)23(35)33-17(4)20-11-31-25(32-12-20)26(27,28)29/h7-12,15,17,22H,5-6,13-14H2,1-4H3,(H,33,35)/t17-,22-/m1/s1 AOHBYHNFISDLHQ-VGOFRKELSA-N 320214 3-(5-methyl- 1,3-thiazol-2- yl)-5-{[(2R)-4- (propan-2- yl)morpholin- 2-yl]methoxy}- N-{(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 381::US10202369, Example 381::US10472354, Example 381 P2X purinoceptor 3 Homo sapiens 16.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320214 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320214&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397576 384223487 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843202 CC(C)N1CCO[C@H](COc2cc(cc(c2)-c2ncc(C)s2)C(=O)N[C@H](C)c2cnc(nc2)C(F)(F)F)C1 InChI=1S/C26H30F3N5O3S/c1-15(2)34-5-6-36-22(13-34)14-37-21-8-18(7-19(9-21)24-30-10-16(3)38-24)23(35)33-17(4)20-11-31-25(32-12-20)26(27,28)29/h7-12,15,17,22H,5-6,13-14H2,1-4H3,(H,33,35)/t17-,22+/m1/s1 AOHBYHNFISDLHQ-VGSWGCGISA-N 320215 3-(5-methyl- 1,3-thiazol-2- yl)-5-{[(2R)-4- (propan-2- yl)morpholin- 2-yl]methoxy}- N-{(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 382::US10202369, Example 382::US10472354, Example 382 P2X purinoceptor 3 Homo sapiens 13.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320215 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320215&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397421 384223488 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843204 C[C@@H](NC(=O)c1cc(OCC2CN(C)CCC2(F)F)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C25H26F5N5O2S/c1-14-9-31-22(38-14)17-6-16(7-20(8-17)37-13-19-12-35(3)5-4-24(19,26)27)21(36)34-15(2)18-10-32-23(33-11-18)25(28,29)30/h6-11,15,19H,4-5,12-13H2,1-3H3,(H,34,36)/t15-,19?/m1/s1 LGPVNMAGAZJDEW-NYRJJRHWSA-N 320216 3-{[4,4- difluoro-1- methylpiperidin- 3-yl]methoxy}-5- (5-methyl-1,3- thiazol-2-yl)- N-{(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide, as a mixture of 2 diastereoisomers::US10174016, Example 383::US10202369, Example 384::US10472354, Example 383 P2X purinoceptor 3 Homo sapiens 2.00 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320216 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320216&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397497 384223489 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843206 C[C@@H](NC(=O)c1cc(OC[C@H]2CN(C)CCC2(F)F)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C25H26F5N5O2S/c1-14-9-31-22(38-14)17-6-16(7-20(8-17)37-13-19-12-35(3)5-4-24(19,26)27)21(36)34-15(2)18-10-32-23(33-11-18)25(28,29)30/h6-11,15,19H,4-5,12-13H2,1-3H3,(H,34,36)/t15-,19-/m1/s1 LGPVNMAGAZJDEW-DNVCBOLYSA-N 420323 US10472354, Example 384 P2X purinoceptor 3 Homo sapiens 3.00 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=420323 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=420323&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843208 C[C@@H](NC(=O)c1cc(OC[C@@H]2CN(C)CCC2(F)F)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C25H26F5N5O2S/c1-14-9-31-22(38-14)17-6-16(7-20(8-17)37-13-19-12-35(3)5-4-24(19,26)27)21(36)34-15(2)18-10-32-23(33-11-18)25(28,29)30/h6-11,15,19H,4-5,12-13H2,1-3H3,(H,34,36)/t15-,19+/m1/s1 LGPVNMAGAZJDEW-BEFAXECRSA-N 320217 3-{[4,4-difluoro-1-methylpiperidin-3-yl]methoxy}-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 384::US10174016, Example 385::US10472354, Example 385 P2X purinoceptor 3 Homo sapiens 3.00 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320217 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320217&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 138374922 384223490 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843210 C[C@@H](NC(=O)c1cc(OCC2(F)CN(C)C2)cc(c1)-c1ncc(C)s1)c1ccc(nc1)C(F)(F)F InChI=1S/C24H24F4N4O2S/c1-14-9-30-22(35-14)18-6-17(7-19(8-18)34-13-23(25)11-32(3)12-23)21(33)31-15(2)16-4-5-20(29-10-16)24(26,27)28/h4-10,15H,11-13H2,1-3H3,(H,31,33)/t15-/m1/s1 YWRAMSXXAJRPGK-OAHLLOKOSA-N 320219 3-[(3-fluoro-1- methylazetidin-3- yl)methoxy]-5-(5- methyl-1,3-thiazol- 2-yl)-N-{(1R)-1-[6- (trifluoromethyl) pyridin-3-yl] ethyl}benzamide::US10174016, Example 386::US10202369, Example 386::US10472354, Example 386 P2X purinoceptor 3 Homo sapiens 24.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320219 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320219&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397321 384223491 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843212 CCc1cnc(s1)-c1cc(OCC2(F)CN(C)C2)cc(c1)C(=O)N[C@H](C)c1ccc(nc1)C(F)(F)F InChI=1S/C25H26F4N4O2S/c1-4-20-11-31-23(36-20)18-7-17(8-19(9-18)35-14-24(26)12-33(3)13-24)22(34)32-15(2)16-5-6-21(30-10-16)25(27,28)29/h5-11,15H,4,12-14H2,1-3H3,(H,32,34)/t15-/m1/s1 HCTVCZSENAWJEB-OAHLLOKOSA-N 320220 3-(5-ethyl-1,3- thiazol-2-yl)-5-[(3- fluoro-1- methylazetidin-3- yl)methoxy]-N- {(1R)-1-[6- (trifluoromethyl) pyridin-3-yl] ethyl}benzamide::US10174016, Example 387::US10202369, Example 387::US10472354, Example 387 P2X purinoceptor 3 Homo sapiens 19.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320220 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320220&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397751 384223492 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843214 C[C@@H](NC(=O)c1cc(OC[C@H]2COCCN2C)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F InChI=1S/C24H26F3N5O3S/c1-14-11-28-23(36-14)17-8-16(9-19(10-17)35-13-18-12-34-7-6-32(18)3)22(33)29-15(2)20-4-5-21(31-30-20)24(25,26)27/h4-5,8-11,15,18H,6-7,12-13H2,1-3H3,(H,29,33)/t15-,18-/m1/s1 SOWWCICJAYGBSY-CRAIPNDOSA-N 320221 3-{[(3R)-4- methylmorpholin-3- yl]methoxy}-5-(5- methyl-1,3-thiazol- 2-yl)-N-{(1R)-1-[6- (trifluoromethyl) pyridazin-3-yl] ethyl}benzamide::US10174016, Example 388::US10202369, Example 388::US10472354, Example 388 P2X purinoceptor 3 Homo sapiens 18.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320221 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320221&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397768 384223493 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843216 C[C@@H](NC(=O)c1cc(OC[C@@H]2COCCN2C)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F InChI=1S/C24H26F3N5O3S/c1-14-11-28-23(36-14)17-8-16(9-19(10-17)35-13-18-12-34-7-6-32(18)3)22(33)29-15(2)20-4-5-21(31-30-20)24(25,26)27/h4-5,8-11,15,18H,6-7,12-13H2,1-3H3,(H,29,33)/t15-,18+/m1/s1 SOWWCICJAYGBSY-QAPCUYQASA-N 320222 3-{[(3S)-4- methylmorpholin-3- yl]methoxy}-5-(5- methyl-1,3-thiazol- 2-yl)-N-{(1R)-1-[6- (trifluoromethyl) pyridazin-3-yl] ethyl}benzamide::US10174016, Example 389::US10202369, Example 389::US10472354, Example 389 P2X purinoceptor 3 Homo sapiens 18.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320222 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320222&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397449 384223494 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843218 CCN1CCO[C@@H](COc2cc(cc(c2)-c2ncc(C)s2)C(=O)N[C@H](C)c2cnc(nc2)C(F)(F)F)C1 InChI=1S/C25H28F3N5O3S/c1-4-33-5-6-35-21(13-33)14-36-20-8-17(7-18(9-20)23-29-10-15(2)37-23)22(34)32-16(3)19-11-30-24(31-12-19)25(26,27)28/h7-12,16,21H,4-6,13-14H2,1-3H3,(H,32,34)/t16-,21-/m1/s1 IJXNJADLTIUKEL-IIBYNOLFSA-N 320223 3-{[(2R)-4-ethylmorpholin-2-yl]methoxy}-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 390::US10202369, Example 390::US10472354, Example 390 P2X purinoceptor 3 Homo sapiens 17.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320223 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320223&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397822 384223495 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843220 C[C@@H](NC(=O)c1cc(OC[C@H]2CN(CC(F)F)CCO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C25H26F5N5O3S/c1-14-8-31-23(39-14)17-5-16(22(36)34-15(2)18-9-32-24(33-10-18)25(28,29)30)6-19(7-17)38-13-20-11-35(3-4-37-20)12-21(26)27/h5-10,15,20-21H,3-4,11-13H2,1-2H3,(H,34,36)/t15-,20-/m1/s1 LANXVVYUHZPONS-FOIQADDNSA-N 320224 3-{[(2R)-4-(2,2-difluoroethyl)morpholin-2-yl]methoxy}-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 391::US10202369, Example 391::US10472354, Example 391 P2X purinoceptor 3 Homo sapiens 19.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320224 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320224&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397746 384223496 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843222 COC(=O)N1CCO[C@@H](COc2cc(cc(c2)-c2ncc(C)s2)C(=O)N[C@H](C)c2cnc(nc2)C(F)(F)F)C1 InChI=1S/C25H26F3N5O5S/c1-14-9-29-22(39-14)17-6-16(21(34)32-15(2)18-10-30-23(31-11-18)25(26,27)28)7-19(8-17)38-13-20-12-33(4-5-37-20)24(35)36-3/h6-11,15,20H,4-5,12-13H2,1-3H3,(H,32,34)/t15-,20-/m1/s1 AMNDVZJYNBRGRX-FOIQADDNSA-N 320225 Methyl (2R)-2-{[3-(5-methyl-1,3-thiazol-2-yl)-5-({(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}carbamoyl)phenoxy]methyl}morpholine-4-carboxylate::US10174016, Example 392::US10202369, Example 392::US10472354, Example 392 P2X purinoceptor 3 Homo sapiens 11.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320225 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320225&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134338451 384223497 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843224 COC(=O)N1CCO[C@H](COc2cc(cc(c2)-c2ncc(C)s2)C(=O)N[C@H](C)c2cnc(nc2)C(F)(F)F)C1 InChI=1S/C25H26F3N5O5S/c1-14-9-29-22(39-14)17-6-16(21(34)32-15(2)18-10-30-23(31-11-18)25(26,27)28)7-19(8-17)38-13-20-12-33(4-5-37-20)24(35)36-3/h6-11,15,20H,4-5,12-13H2,1-3H3,(H,32,34)/t15-,20+/m1/s1 AMNDVZJYNBRGRX-QRWLVFNGSA-N 320226 Methyl (2S)-2- {[3-(5-methyl- 1,3-thiazol-2- yl)-5-({(1R)-1- [2- (trifluoromethyl) pyrimidin-5-yl] ethyl}carbamoyl) phenoxy]methyl} morpholine-4- carboxylate::US10174016, Example 393::US10202369, Example 393::US10472354, Example 393 P2X purinoceptor 3 Homo sapiens 24.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320226 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320226&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134338452 384223498 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843226 C[C@@H](NC(=O)c1cc(OCC2CNC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C22H22F3N5O2S/c1-12-6-27-20(33-12)16-3-15(4-18(5-16)32-11-14-7-26-8-14)19(31)30-13(2)17-9-28-21(29-10-17)22(23,24)25/h3-6,9-10,13-14,26H,7-8,11H2,1-2H3,(H,30,31)/t13-/m1/s1 MHYFOJHMKOGSKR-CYBMUJFWSA-N 320227 3-(Azetidin-3-ylmethoxy)-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 394::US10202369, Example 394::US10472354, Example 394 P2X purinoceptor 3 Homo sapiens 82.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320227 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320227&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397376 384223499 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843228 C[C@@H](NC(=O)c1cc(OC[C@H]2COCC(=O)N2C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H24F3N5O4S/c1-13-7-28-22(37-13)16-4-15(5-19(6-16)36-11-18-10-35-12-20(33)32(18)3)21(34)31-14(2)17-8-29-23(30-9-17)24(25,26)27/h4-9,14,18H,10-12H2,1-3H3,(H,31,34)/t14-,18-/m1/s1 SDFLFPYVVNTAIN-RDTXWAMCSA-N 320228 3-{[(3R)-4-methyl-5-oxomorpholin-3-yl]methoxyl}-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 395::US10202369, Example 395::US10472354, Example 395 P2X purinoceptor 3 Homo sapiens 30.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320228 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320228&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397767 384223500 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843230 C[C@@H](NC(=O)c1cc(OC[C@H]2COCC(=O)N2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H22F3N5O4S/c1-12-6-27-21(36-12)15-3-14(4-18(5-15)35-10-17-9-34-11-19(32)31-17)20(33)30-13(2)16-7-28-22(29-8-16)23(24,25)26/h3-8,13,17H,9-11H2,1-2H3,(H,30,33)(H,31,32)/t13-,17-/m1/s1 QBCIMXIDQXCQLC-CXAGYDPISA-N 320229 3-(5-methyl-1,3- thiazol-2-yl)-5- {[(3R)-5- oxomorpholin-3- yl]methoxy}-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5-yl] ethyl}benzamide::US10174016, Example 396::US10202369, Example 396::US10472354, Example 396 P2X purinoceptor 3 Homo sapiens 22.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320229 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320229&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397733 384223501 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843232 C[C@@H](NC(=O)c1cc(OC[C@@H]2CN(C)C(=O)O2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H22F3N5O4S/c1-12-7-27-20(36-12)15-4-14(5-17(6-15)34-11-18-10-31(3)22(33)35-18)19(32)30-13(2)16-8-28-21(29-9-16)23(24,25)26/h4-9,13,18H,10-11H2,1-3H3,(H,30,32)/t13-,18+/m1/s1 OAEQMLBAMDEFGR-ACJLOTCBSA-N 320230 3-{[(5S)-3-methyl-2- oxo-1,3-oxazolidin- 5-yl]methoxy}-5-(5- methyl-1,3-thiazol- 2-yl)-N-{(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 397::US10202369, Example 397::US10472354, Example 397 P2X purinoceptor 3 Homo sapiens 15.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320230 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320230&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397304 384223502 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843234 C[C@@H](NC(=O)c1cc(OC[C@H]2CN(C)C(=O)O2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H22F3N5O4S/c1-12-7-27-20(36-12)15-4-14(5-17(6-15)34-11-18-10-31(3)22(33)35-18)19(32)30-13(2)16-8-28-21(29-9-16)23(24,25)26/h4-9,13,18H,10-11H2,1-3H3,(H,30,32)/t13-,18-/m1/s1 OAEQMLBAMDEFGR-FZKQIMNGSA-N 320231 3-{[(5R)-3-methyl-2- oxo-1,3-oxazolidin- 5-yl]methoxy}-5-(5- methyl-1,3-thiazol- 2-yl)-N-{(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 398::US10202369, Example 398::US10472354, Example 398 P2X purinoceptor 3 Homo sapiens 17.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320231 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320231&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397297 384223503 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843236 C[C@@H](NC(=O)c1cc(OC[C@H]2CN(C)C(=O)CO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H24F3N5O4S/c1-13-7-28-22(37-13)16-4-15(5-18(6-16)35-11-19-10-32(3)20(33)12-36-19)21(34)31-14(2)17-8-29-23(30-9-17)24(25,26)27/h4-9,14,19H,10-12H2,1-3H3,(H,31,34)/t14-,19-/m1/s1 UCMZCPXWJACEJN-AUUYWEPGSA-N 320232 3-{[(2R)-4-methyl-5- oxomorpholin-2-yl] methoxy}-5-(5- methyl-1,3-thiazol- 2-yl)-N-{(1R)-1-[2- (trifluoromethyl) pyrimidin-5-yl] ethyl}benzamide::US10174016, Example 399::US10202369, Example 399::US10472354, Example 399 P2X purinoceptor 3 Homo sapiens 69.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320232 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320232&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397565 384223504 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51215543 Cc1cc(Cl)c(OCCO)cc1NC(=O)C1=CNC(=O)C[C@H]1c1ccc(F)cc1 InChI=1S/C21H20ClFN2O4/c1-12-8-17(22)19(29-7-6-26)10-18(12)25-21(28)16-11-24-20(27)9-15(16)13-2-4-14(23)5-3-13/h2-5,8,10-11,15,26H,6-7,9H2,1H3,(H,24,27)(H,25,28)/t15-/m0/s1 GGNOURYPUNZEOQ-HNNXBMFYSA-N 50499490 CHEMBL3741992 P2X purinoceptor 3 Homo sapiens >10000 ChEMBL 10.1021/acs.jmedchem.5b00365 10.7270/Q2QZ2DZ2 26460788 Lopez-Tapia, F; Walker, KA; Brotherton-Pleiss, C; Caroon, J; Nitzan, D; Lowrie, L; Gleason, S; Zhao, SH; Berger, J; Cockayne, D; Phippard, D; Suttmann, R; Fitch, WL; Bourdet, D; Rege, P; Huang, X; Broadbent, S; Dvorak, C; Zhu, J; Wagner, P; Padilla, F; Loe, B; Jahangir, A; Alker, A Hoffmann-La Roche, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50499490 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50499490&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 46832336 433911391 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842440 C[C@@H](NC(=O)c1cc(OCC2CC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C22H21F3N4O2S/c1-12-8-26-20(32-12)16-5-15(6-18(7-16)31-11-14-3-4-14)19(30)29-13(2)17-9-27-21(28-10-17)22(23,24)25/h5-10,13-14H,3-4,11H2,1-2H3,(H,29,30)/t13-/m1/s1 KPIHUQDIFGXEHA-CYBMUJFWSA-N 319834 3-(Cyclopropylmethoxy)-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 1::US10202369, Example 1::US10472354, Example 1 P2X purinoceptor 3 Homo sapiens 4.00 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319834 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319834&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397250 384223114 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842442 Cc1cnc(s1)-c1cc(OCC2CC2)cc(c1)C(=O)NCc1ccc(C)nn1 InChI=1S/C21H22N4O2S/c1-13-3-6-18(25-24-13)11-22-20(26)16-7-17(21-23-10-14(2)28-21)9-19(8-16)27-12-15-4-5-15/h3,6-10,15H,4-5,11-12H2,1-2H3,(H,22,26) LHMIEJIRNSAGER-UHFFFAOYSA-N 319835 3-(Cyclopropylmethoxy)-N-[(6-methylpyridazin-3-yl)methyl]-5-(5-methyl-1,3-thiazol-2-yl)benzamide::US10174016, Example 2::US10202369, Example 2::US10472354, Example 2 P2X purinoceptor 3 Homo sapiens 19.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319835 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319835&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397260 384223115 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842444 Cc1cnc(s1)-c1cc(OCC2CC2)cc(c1)C(=O)NCc1cnc(C)cn1 InChI=1S/C21H22N4O2S/c1-13-8-23-18(10-22-13)11-24-20(26)16-5-17(21-25-9-14(2)28-21)7-19(6-16)27-12-15-3-4-15/h5-10,15H,3-4,11-12H2,1-2H3,(H,24,26) SHCAJJQUYCQWRM-UHFFFAOYSA-N 319836 3-(Cyclopropylmethoxy)-N-[(5-methylpyrazin-2-yl)methyl]-5-(5-methyl-1,3-thiazol-2-yl)benzamide::US10174016, Example 3::US10202369, Example 3::US10472354, Example 3 P2X purinoceptor 3 Homo sapiens 26.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319836 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319836&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397194 384223116 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842446 C[C@@H](NC(=O)c1cc(OCC2CC2)cc(c1)-c1ncc(C)s1)c1cnc(C)cn1 InChI=1S/C22H24N4O2S/c1-13-9-24-20(11-23-13)15(3)26-21(27)17-6-18(22-25-10-14(2)29-22)8-19(7-17)28-12-16-4-5-16/h6-11,15-16H,4-5,12H2,1-3H3,(H,26,27)/t15-/m1/s1 DYWYLXQLERQEEM-OAHLLOKOSA-N 319837 3-(Cyclopropylmethoxy)-N-[(1R)-1-(5-methylpyrazin-2-yl)ethyl]-5-(5-methyl-1,3-thiazol-2-yl)benzamide::US10174016, Example 4::US10202369, Example 4::US10472354, Example 4 P2X purinoceptor 3 Homo sapiens 9.00 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319837 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319837&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397428 384223117 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842448 CC(NC(=O)c1cc(OCC2CC2)cc(c1)-c1ncc(C)s1)c1ncc(F)cc1Cl InChI=1S/C22H21ClFN3O2S/c1-12-9-26-22(30-12)16-5-15(6-18(7-16)29-11-14-3-4-14)21(28)27-13(2)20-19(23)8-17(24)10-25-20/h5-10,13-14H,3-4,11H2,1-2H3,(H,27,28) CGCJNRQFWMKWFU-UHFFFAOYSA-N 319838 N-[1-(3-Chloro-5-fluoropyridin-2-yl)ethyl]-3-(cyclopropylmethoxy)-5-(5-methyl-1,3-thiazol-2-yl)benzamide::US10174016, Example 5::US10202369, Example 5::US10472354, Example 5 P2X purinoceptor 3 Homo sapiens 16.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319838 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319838&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397491 384223118 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842450 CC(NC(=O)c1cc(OCC2CC2)cc(c1)-c1ncc(C)s1)c1ncc(Cl)cc1F InChI=1S/C22H21ClFN3O2S/c1-12-9-26-22(30-12)16-5-15(6-18(7-16)29-11-14-3-4-14)21(28)27-13(2)20-19(24)8-17(23)10-25-20/h5-10,13-14H,3-4,11H2,1-2H3,(H,27,28) YIPUFXDTAKNGSX-UHFFFAOYSA-N 319839 N-[1-(5-Chloro-3-fluoropyridin-2-yl)ethyl]-3-(cyclopropylmethoxy)-5-(5-methyl-1,3-thiazol-2-yl)benzamide::US10174016, Example 6::US10202369, Example 6::US10472354, Example 6 P2X purinoceptor 3 Homo sapiens 4.00 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319839 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319839&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397488 384223119 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842452 C[C@@H](NC(=O)c1cc(OCC2CC2)cc(c1)-c1ncc(C)s1)c1nnc(C)s1 InChI=1S/C20H22N4O2S2/c1-11-9-21-20(27-11)16-6-15(7-17(8-16)26-10-14-4-5-14)18(25)22-12(2)19-24-23-13(3)28-19/h6-9,12,14H,4-5,10H2,1-3H3,(H,22,25)/t12-/m1/s1 QOCVVHCSVZQPAR-GFCCVEGCSA-N 319840 3-(Cyclopropylmethoxy)-N-[(1R)-1-(5-methyl-1,3,4-thiadiazol-2-yl)ethyl]-5-(5-methyl-1,3-thiazol-2-yl)benzamide::US10174016, Example 7::US10202369, Example 7::US10472354, Example 7 P2X purinoceptor 3 Homo sapiens 8.00 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319840 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319840&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397154 384223120 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842454 C[C@@H](NC(=O)c1cc(OCC2CC2)cc(c1)-c1ncc(C)s1)c1ccc(C)nn1 InChI=1S/C22H24N4O2S/c1-13-4-7-20(26-25-13)15(3)24-21(27)17-8-18(22-23-11-14(2)29-22)10-19(9-17)28-12-16-5-6-16/h4,7-11,15-16H,5-6,12H2,1-3H3,(H,24,27)/t15-/m1/s1 ZZPHBEIBURIANJ-OAHLLOKOSA-N 319841 3-(Cyclopropylmethoxy)-N-[(1R)-1-(6-methylpyridazin-3-yl)ethyl]-5-(5-methyl-1,3-thiazol-2-yl)benzamide::US10174016, Example 8::US10202369, Example 8::US10472354, Example 8 P2X purinoceptor 3 Homo sapiens 3.00 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319841 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319841&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397204 384223121 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842456 C[C@@H](NC(=O)c1cc(OCC2CC2)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F InChI=1S/C22H21F3N4O2S/c1-12-10-26-21(32-12)16-7-15(8-17(9-16)31-11-14-3-4-14)20(30)27-13(2)18-5-6-19(29-28-18)22(23,24)25/h5-10,13-14H,3-4,11H2,1-2H3,(H,27,30)/t13-/m1/s1 FDEHTNMFMQMRCT-CYBMUJFWSA-N 319842 3-(Cyclopropylmethoxy)-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[6-(trifluoromethyl)pyridazin-3-yl]ethyl}benzamide::US10174016, Example 9::US10202369, Example 9::US10472354, Example 9 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319842 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319842&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397573 384223122 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842458 C[C@@H](NC(=O)c1cc(OCC2CC2)cc(c1)-c1ncc(C)s1)c1cnc(C)nc1 InChI=1S/C22H24N4O2S/c1-13-9-25-22(29-13)18-6-17(7-20(8-18)28-12-16-4-5-16)21(27)26-14(2)19-10-23-15(3)24-11-19/h6-11,14,16H,4-5,12H2,1-3H3,(H,26,27)/t14-/m1/s1 HEHYSAYIHLPEGC-CQSZACIVSA-N 319843 3-(Cyclopropylmethoxy)-N-[(1R)-1-(2-methylpyrimidin-5-yl)ethyl]-5-(5-methyl-1,3-thiazol-2-yl)benzamide::US10174016, Example 10::US10202369, Example 10::US10472354, Example 10 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319843 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319843&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397702 384223123 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842460 C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C22H21F3N4O3S/c1-12-8-26-20(33-12)15-5-14(6-18(7-15)32-17-3-4-31-11-17)19(30)29-13(2)16-9-27-21(28-10-16)22(23,24)25/h5-10,13,17H,3-4,11H2,1-2H3,(H,29,30)/t13-,17-/m1/s1 GTQPEQGDLVSFJO-CXAGYDPISA-N 319844 3-(5-Methyl-1,3-thiazol-2-yl)-5-[(3R)-tetrahydrofuran-3-yloxy]-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 11::US10202369, Example 11::US10472354, Example 291 P2X purinoceptor 3 Homo sapiens 8.00 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319844 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319844&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397587 384223124 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842462 C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1cnc(C)cn1 InChI=1S/C22H24N4O3S/c1-13-9-24-20(11-23-13)15(3)26-21(27)16-6-17(22-25-10-14(2)30-22)8-19(7-16)29-18-4-5-28-12-18/h6-11,15,18H,4-5,12H2,1-3H3,(H,26,27)/t15-,18-/m1/s1 GGLGXVJJVCGSBA-CRAIPNDOSA-N 319849 N-[(1R)-1-(5-methylpyrazin-2-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(3R)-tetrahydrofuran-3-yloxy]benzamide::US10174016, Example 16::US10202369, Example 16::US10472354, Example 16 P2X purinoceptor 3 Homo sapiens 283 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319849 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319849&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397267 384223129 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842464 CC(NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ncc(F)cc1Cl InChI=1S/C22H21ClFN3O3S/c1-12-9-26-22(31-12)15-5-14(6-18(7-15)30-17-3-4-29-11-17)21(28)27-13(2)20-19(23)8-16(24)10-25-20/h5-10,13,17H,3-4,11H2,1-2H3,(H,27,28)/t13?,17-/m1/s1 YETTUNLUNMEXML-LRHAYUFXSA-N 319846 N-[1-(3-chloro-5-fluoropyridin-2-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(3R)-tetrahydrofuran-3-yloxy]benzamide::US10174016, Example 13::US10202369, Example 13::US10472354, Example 13 P2X purinoceptor 3 Homo sapiens 21.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319846 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319846&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397669 384223126 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842466 CC(NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ncc(Cl)cc1F InChI=1S/C22H21ClFN3O3S/c1-12-9-26-22(31-12)15-5-14(6-18(7-15)30-17-3-4-29-11-17)21(28)27-13(2)20-19(24)8-16(23)10-25-20/h5-10,13,17H,3-4,11H2,1-2H3,(H,27,28)/t13?,17-/m1/s1 DLODQDUFIVUCLQ-LRHAYUFXSA-N 319847 N-[1-(5-chloro-3-fluoropyridin-2-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(3R)-tetrahydrofuran-3-yloxy]benzamide::US10174016, Example 14::US10202369, Example 14::US10472354, Example 14 P2X purinoceptor 3 Homo sapiens 8.00 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319847 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319847&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397583 384223127 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842468 C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ccc(Cl)cn1 InChI=1S/C22H22ClN3O3S/c1-13-10-25-22(30-13)16-7-15(8-19(9-16)29-18-5-6-28-12-18)21(27)26-14(2)20-4-3-17(23)11-24-20/h3-4,7-11,14,18H,5-6,12H2,1-2H3,(H,26,27)/t14-,18-/m1/s1 DURBVTDNVKUTOV-RDTXWAMCSA-N 319848 N-[(1R)-1-(5-chloropyridin-2-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(3R)-tetrahydrofuran-3-yloxy]benzamide::US10174016, Example 15::US10202369, Example 15::US10472354, Example 15 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319848 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319848&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397630 384223128 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842470 C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1cnc(C)cn1 InChI=1S/C22H24N4O3S/c1-13-9-24-20(11-23-13)15(3)26-21(27)16-6-17(22-25-10-14(2)30-22)8-19(7-16)29-18-4-5-28-12-18/h6-11,15,18H,4-5,12H2,1-3H3,(H,26,27)/t15-,18-/m1/s1 GGLGXVJJVCGSBA-CRAIPNDOSA-N 319849 N-[(1R)-1-(5-methylpyrazin-2-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(3R)-tetrahydrofuran-3-yloxy]benzamide::US10174016, Example 16::US10202369, Example 16::US10472354, Example 16 P2X purinoceptor 3 Homo sapiens 38.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319849 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319849&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397267 384223129 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842472 Cc1cnc(s1)-c1cc(O[C@@H]2CCOC2)cc(c1)C(=O)NCc1ccc(C)nn1 InChI=1S/C21H22N4O3S/c1-13-3-4-17(25-24-13)11-22-20(26)15-7-16(21-23-10-14(2)29-21)9-19(8-15)28-18-5-6-27-12-18/h3-4,7-10,18H,5-6,11-12H2,1-2H3,(H,22,26)/t18-/m1/s1 VKRRMZCTKMLCQJ-GOSISDBHSA-N 319850 N-[(6-methylpyridazin-3-yl)methyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(3R)-tetrahydrofuran-3-yloxy]benzamide::US10174016, Example 17::US10202369, Example 17::US10472354, Example 17 P2X purinoceptor 3 Homo sapiens 35.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319850 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319850&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397146 384223130 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842474 C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ccc(C)nn1 InChI=1S/C22H24N4O3S/c1-13-4-5-20(26-25-13)15(3)24-21(27)16-8-17(22-23-11-14(2)30-22)10-19(9-16)29-18-6-7-28-12-18/h4-5,8-11,15,18H,6-7,12H2,1-3H3,(H,24,27)/t15-,18-/m1/s1 JJXMVDHMQZPOJY-CRAIPNDOSA-N 319851 N-[(1R)-1-(6-methylpyridazin-3-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(3R)-tetrahydrofuran-3-yloxy]benzamide::US10174016, Example 18::US10202369, Example 18::US10472354, Example 18 P2X purinoceptor 3 Homo sapiens 34.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319851 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319851&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397758 384223131 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842476 C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F InChI=1S/C22H21F3N4O3S/c1-12-10-26-21(33-12)15-7-14(8-17(9-15)32-16-5-6-31-11-16)20(30)27-13(2)18-3-4-19(29-28-18)22(23,24)25/h3-4,7-10,13,16H,5-6,11H2,1-2H3,(H,27,30)/t13-,16-/m1/s1 DNHMMXLROIMBSA-CZUORRHYSA-N 319852 3-(5-Methyl-1,3-thiazol-2-yl)-5-[(3R)-tetrahydrofuran-3-yloxy]-N-{(1R)-1-[6-(trifluoromethyl)pyridazin-3-yl]ethyl}benzamide::US10174016, Example 19::US10202369, Example 19::US10472354, Example 19 P2X purinoceptor 3 Homo sapiens 19.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319852 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319852&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397747 384223132 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842478 C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1nnc(C)s1 InChI=1S/C20H22N4O3S2/c1-11-9-21-20(28-11)15-6-14(7-17(8-15)27-16-4-5-26-10-16)18(25)22-12(2)19-24-23-13(3)29-19/h6-9,12,16H,4-5,10H2,1-3H3,(H,22,25)/t12-,16-/m1/s1 WVNVOAPVSAUSTP-MLGOLLRUSA-N 319853 N-[(1R)-1-(5-methyl-1,3,4-thiadiazol-2-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(3R)-tetrahydrofuran-3-yloxy]benzamide::US10174016, Example 20::US10202369, Example 20::US10472354, Example 20 P2X purinoceptor 3 Homo sapiens 35.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319853 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319853&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397835 384223133 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842480 Cc1cnc(s1)-c1cc(O[C@@H]2CCOC2)cc(c1)C(=O)NCc1ccc(nn1)C(F)(F)F InChI=1S/C21H19F3N4O3S/c1-12-9-26-20(32-12)14-6-13(7-17(8-14)31-16-4-5-30-11-16)19(29)25-10-15-2-3-18(28-27-15)21(22,23)24/h2-3,6-9,16H,4-5,10-11H2,1H3,(H,25,29)/t16-/m1/s1 YZCYRJHHBOIVER-MRXNPFEDSA-N 319854 3-(5-Methyl-1,3-thiazol-2-yl)-5-[(3R)-tetrahydrofuran-3-yloxy]-N-{[6-(trifluoromethyl)pyridazin-3-yl]methyl}benzamide::US10174016, Example 21::US10202369, Example 21::US10472354, Example 21 P2X purinoceptor 3 Homo sapiens 71.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319854 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319854&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397575 384223134 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842482 CC[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H23F3N4O3S/c1-3-19(16-10-28-22(29-11-16)23(24,25)26)30-20(31)14-6-15(21-27-9-13(2)34-21)8-18(7-14)33-17-4-5-32-12-17/h6-11,17,19H,3-5,12H2,1-2H3,(H,30,31)/t17-,19-/m1/s1 VUXDKUAYZMWTBM-IEBWSBKVSA-N 319855 3-(5-Methyl-1,3-thiazol-2-yl)-5-[(3R)-tetrahydrofuran-3-yloxy]-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]propyl}benzamide::US10174016, Example 22::US10202369, Example 22::US10472354, Example 22 P2X purinoceptor 3 Homo sapiens 132 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319855 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319855&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397246 384223135 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842484 C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)C1=[S]C=C(C)N1)c1cnc(C)nc1 InChI=1S/C22H25N4O3S/c1-13-12-30-22(25-13)17-6-16(7-20(8-17)29-19-4-5-28-11-19)21(27)26-14(2)18-9-23-15(3)24-10-18/h6-10,12,14,19,25H,4-5,11H2,1-3H3,(H,26,27)/t14-,19-/m1/s1 XUSIIGAFSFFFBZ-AUUYWEPGSA-N 419937 US10472354, Example 23 P2X purinoceptor 3 Homo sapiens 30.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=419937 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=419937&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842486 C[C@@H](NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ccc(C)nc1 InChI=1S/C23H25N3O3S/c1-14-4-5-17(12-24-14)16(3)26-22(27)18-8-19(23-25-11-15(2)30-23)10-21(9-18)29-20-6-7-28-13-20/h4-5,8-12,16,20H,6-7,13H2,1-3H3,(H,26,27)/t16-,20+/m1/s1 KGDPEGCMVCXNPY-UZLBHIALSA-N 319863 N-[(1R)-1-(6- Methylpyridin- 3-yl)ethyl]-3- (5-methyl-1,3- thiazol-2-yl)-5- [(3S)- tetrahydrofuran- 3-yloxy] benzamide::US10174016, Example 30::US10202369, Example 30::US10472354, Example 30 P2X purinoceptor 3 Homo sapiens 36.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319863 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319863&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397828 384223143 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842488 C[C@@H](NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ccc(C)nn1 InChI=1S/C22H24N4O3S/c1-13-4-5-20(26-25-13)15(3)24-21(27)16-8-17(22-23-11-14(2)30-22)10-19(9-16)29-18-6-7-28-12-18/h4-5,8-11,15,18H,6-7,12H2,1-3H3,(H,24,27)/t15-,18+/m1/s1 JJXMVDHMQZPOJY-QAPCUYQASA-N 319858 N-[(1R)-1-(6-Methylpyridazin-3-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(3S)-tetrahydrofuran-3-yloxy]benzamide::US10174016, Example 25::US10202369, Example 25::US10472354, Example 25 P2X purinoceptor 3 Homo sapiens 39.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319858 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319858&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397569 384223138 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842490 C[C@@H](NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C22H21F3N4O3S/c1-12-8-26-20(33-12)15-5-14(6-18(7-15)32-17-3-4-31-11-17)19(30)29-13(2)16-9-27-21(28-10-16)22(23,24)25/h5-10,13,17H,3-4,11H2,1-2H3,(H,29,30)/t13-,17+/m1/s1 GTQPEQGDLVSFJO-DYVFJYSZSA-N 319859 3-(5-Methyl-1,3-thiazol-2-yl)-5-[(3S)-tetrahydrofuran-3-yloxy]-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 26::US10202369, Example 26::US10472354, Example 26 P2X purinoceptor 3 Homo sapiens 8.00 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319859 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319859&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397418 384223139 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842492 C[C@@H](NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ccc(Cl)cn1 InChI=1S/C22H22ClN3O3S/c1-13-10-25-22(30-13)16-7-15(8-19(9-16)29-18-5-6-28-12-18)21(27)26-14(2)20-4-3-17(23)11-24-20/h3-4,7-11,14,18H,5-6,12H2,1-2H3,(H,26,27)/t14-,18+/m1/s1 DURBVTDNVKUTOV-KDOFPFPSSA-N 319860 N-[(1R)-1-(5-Chloropyridin-2-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(3S)-tetrahydrofuran-3-yloxy]benzamide::US10174016, Example 27::US10202369, Example 27::US10472354, Example 27 P2X purinoceptor 3 Homo sapiens 25.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319860 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319860&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397158 384223140 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842494 C[C@@H](NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ccc(C)cn1 InChI=1S/C23H25N3O3S/c1-14-4-5-21(24-11-14)16(3)26-22(27)17-8-18(23-25-12-15(2)30-23)10-20(9-17)29-19-6-7-28-13-19/h4-5,8-12,16,19H,6-7,13H2,1-3H3,(H,26,27)/t16-,19+/m1/s1 CFTQNAYGOFQJGD-APWZRJJASA-N 319861 N-[(1R)-1-(5-Methylpyridin-2-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(3S)-tetrahydrofuran-3-yloxy]benzamide::US10174016, Example 28::US10202369, Example 28::US10472354, Example 28 P2X purinoceptor 3 Homo sapiens 48.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319861 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319861&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397224 384223141 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842496 C[C@@H](NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1cnc(C)cn1 InChI=1S/C22H24N4O3S/c1-13-9-24-20(11-23-13)15(3)26-21(27)16-6-17(22-25-10-14(2)30-22)8-19(7-16)29-18-4-5-28-12-18/h6-11,15,18H,4-5,12H2,1-3H3,(H,26,27)/t15-,18+/m1/s1 GGLGXVJJVCGSBA-QAPCUYQASA-N 319862 N-[(1R)-1-(5-Methylpyrazin-2-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(3S)-tetrahydrofuran-3-yloxy]benzamide::US10174016, Example 29::US10472354, Example 29 P2X purinoceptor 3 Homo sapiens 79.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319862 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319862&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397726 384223142 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842498 C[C@@H](NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ccc(C)nc1 InChI=1S/C23H25N3O3S/c1-14-4-5-17(12-24-14)16(3)26-22(27)18-8-19(23-25-11-15(2)30-23)10-21(9-18)29-20-6-7-28-13-20/h4-5,8-12,16,20H,6-7,13H2,1-3H3,(H,26,27)/t16-,20+/m1/s1 KGDPEGCMVCXNPY-UZLBHIALSA-N 319863 N-[(1R)-1-(6- Methylpyridin- 3-yl)ethyl]-3- (5-methyl-1,3- thiazol-2-yl)-5- [(3S)- tetrahydrofuran- 3-yloxy] benzamide::US10174016, Example 30::US10202369, Example 30::US10472354, Example 30 P2X purinoceptor 3 Homo sapiens 38.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319863 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319863&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397828 384223143 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842500 Cc1cnc(s1)-c1cc(OCC#C)cc(c1)C(=O)NCc1ccc(C)nn1 InChI=1S/C20H18N4O2S/c1-4-7-26-18-9-15(8-16(10-18)20-22-11-14(3)27-20)19(25)21-12-17-6-5-13(2)23-24-17/h1,5-6,8-11H,7,12H2,2-3H3,(H,21,25) JDOBHPRLWOBCFP-UHFFFAOYSA-N 319864 N-[(6- Methylpyridazin- 3-yl)methyl]-3- (5-methyl-1,3- thiazol-2-yl)-5- (prop-2-yn-1- yloxy) benzamide::US10174016, Example 31::US10202369, Example 31::US10472354, Example 31 P2X purinoceptor 3 Homo sapiens 173 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319864 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319864&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397457 384223144 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842502 Cc1cnc(s1)-c1cc(OCC#C)cc(c1)C(=O)NCc1ncc(Cl)cc1F InChI=1S/C20H15ClFN3O2S/c1-3-4-27-16-6-13(5-14(7-16)20-25-9-12(2)28-20)19(26)24-11-18-17(22)8-15(21)10-23-18/h1,5-10H,4,11H2,2H3,(H,24,26) VKJAMZXKIQCHSG-UHFFFAOYSA-N 322220 N-[(5-Chloro-3- fluoropyridin-2- yl)methyl]-3-(5- methyl-1,3- thiazol-2-yl)-5- (prop-2-yn-1- yloxy) benzamide::US10183937, Example 32::US10202369, Example 32::US10472354, Example 32 P2X purinoceptor 3 Homo sapiens 24.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322220 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322220&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397185 384225297 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842504 C[C@@H](NC(=O)c1cc(OCC#C)cc(c1)-c1ncc(C)s1)c1ccc(C)nc1 InChI=1S/C22H21N3O2S/c1-5-8-27-20-10-18(9-19(11-20)22-24-12-15(3)28-22)21(26)25-16(4)17-7-6-14(2)23-13-17/h1,6-7,9-13,16H,8H2,2-4H3,(H,25,26)/t16-/m1/s1 ZCHZUISZWKOUTB-MRXNPFEDSA-N 319866 N-[(1R)-1-(6- Methylpyridin- 3-yl)ethyl]-3- (5-methyl-1,3- thiazol-2-yl)-5- (prop-2-yn-1- yloxy) benzamide::US10174016, Example 33::US10202369, Example 33::US10472354, Example 33 P2X purinoceptor 3 Homo sapiens 29.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319866 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319866&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397790 384223146 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842506 C[C@@H](NC(=O)c1cc(OCC#C)cc(c1)-c1ncc(C)s1)c1cnc(C)cn1 InChI=1S/C21H20N4O2S/c1-5-6-27-18-8-16(7-17(9-18)21-24-11-14(3)28-21)20(26)25-15(4)19-12-22-13(2)10-23-19/h1,7-12,15H,6H2,2-4H3,(H,25,26)/t15-/m1/s1 UJLVWKMINNYJSM-OAHLLOKOSA-N 319867 N-[(1R)-1-(5- Methylpyrazin- 2-yl)ethyl]-3- (5-methyl-1,3- thiazol-2-yl)-5- (prop-2-yn-1- yloxy) benzamide::US10174016, Example 34::US10202369, Example 34::US10472354, Example 34 P2X purinoceptor 3 Homo sapiens 111 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319867 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319867&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397514 384223147 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843238 C[C@@H](NC(=O)c1cc(OC[C@@H]2CNC(=O)CO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H22F3N5O4S/c1-12-6-28-21(36-12)15-3-14(4-17(5-15)34-10-18-9-27-19(32)11-35-18)20(33)31-13(2)16-7-29-22(30-8-16)23(24,25)26/h3-8,13,18H,9-11H2,1-2H3,(H,27,32)(H,31,33)/t13-,18+/m1/s1 SQKDWNUUISQXQF-ACJLOTCBSA-N 320233 3-(5-methyl-1,3- thiazol-2-yl)-5- {[(2S)-5- oxomorpholin-2- yl]methoxy}-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 400::US10202369, Example 400::US10472354, Example 400 P2X purinoceptor 3 Homo sapiens 59.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320233 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320233&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397173 384223505 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843240 C[C@@H](NC(=O)c1cc(OC[C@@H]2CN(C)C(=O)CO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H24F3N5O4S/c1-13-7-28-22(37-13)16-4-15(5-18(6-16)35-11-19-10-32(3)20(33)12-36-19)21(34)31-14(2)17-8-29-23(30-9-17)24(25,26)27/h4-9,14,19H,10-12H2,1-3H3,(H,31,34)/t14-,19+/m1/s1 UCMZCPXWJACEJN-KUHUBIRLSA-N 320234 3-{[(2S)-4-methyl-5- oxomorpholin-2-yl] methoxy}-5-(5- methyl-1,3-thiazol- 2-yl)-N-{(1R)-1-[2- (trifluoromethyl) pyrimidin-5-yl] ethyl}benzamide::US10174016, Example 401::US10202369, Example 401::US10472354, Example 401 P2X purinoceptor 3 Homo sapiens 30.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320234 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320234&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397710 384223506 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843242 C[C@@H](NC(=O)c1cc(OC[C@@H]2COCC(=O)N2C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H24F3N5O4S/c1-13-7-28-22(37-13)16-4-15(5-19(6-16)36-11-18-10-35-12-20(33)32(18)3)21(34)31-14(2)17-8-29-23(30-9-17)24(25,26)27/h4-9,14,18H,10-12H2,1-3H3,(H,31,34)/t14-,18+/m1/s1 SDFLFPYVVNTAIN-KDOFPFPSSA-N 320235 3-{[(3S)-4-methyl-5- oxomorpholin-3-yl] methoxy}-5-(5- methyl-1,3-thiazol- 2-yl)-N-{(1R)-1-[2- (trifluoromethyl) pyrimidin-5-yl] ethyl}benzamide::US10174016, Example 402::US10472354, Example 402 P2X purinoceptor 3 Homo sapiens 21.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320235 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320235&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397212 384223507 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843244 C[C@@H](NC(=O)c1cc(OC[C@@H]2COCC(=O)N2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H22F3N5O4S/c1-12-6-27-21(36-12)15-3-14(4-18(5-15)35-10-17-9-34-11-19(32)31-17)20(33)30-13(2)16-7-28-22(29-8-16)23(24,25)26/h3-8,13,17H,9-11H2,1-2H3,(H,30,33)(H,31,32)/t13-,17+/m1/s1 QBCIMXIDQXCQLC-DYVFJYSZSA-N 320236 3-(5-methyl-1,3- thiazol-2-yl)-5- {[(3S)-5- oxomorpholin-3- yl]methoxy}-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 403::US10472354, Example 403 P2X purinoceptor 3 Homo sapiens 56.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320236 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320236&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397456 384223508 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843246 C[C@@H](NC(=O)c1cc(OCC23CC(CO2)N(C3)C(=O)OC(C)(C)C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C29H32F3N5O5S/c1-16-10-33-24(43-16)19-6-18(23(38)36-17(2)20-11-34-25(35-12-20)29(30,31)32)7-22(8-19)40-15-28-9-21(13-41-28)37(14-28)26(39)42-27(3,4)5/h6-8,10-12,17,21H,9,13-15H2,1-5H3,(H,36,38)/t17-,21?,28?/m1/s1 FPSSQFUABOQNNZ-RWNQLPSJSA-N 320237 US10174016, Example 404::US10202369, Example 404::US10472354, Example 404::tert-butyl 1-{[3-(5- methyl-1,3-thiazol- 2-yl)-5-({(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}carbamoyl) phenoxy]methyl}-2- oxa-5- azabicyclo[2.2.1] heptane-5- carboxylate, as a mixture of 2 diastereoisomers P2X purinoceptor 3 Homo sapiens 44.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320237 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320237&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397508 384223509 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843248 CC(C)N1CC2(COc3cc(cc(c3)-c3ncc(C)s3)C(=O)N[C@H](C)c3cnc(nc3)C(F)(F)F)CC1CO2 InChI=1S/C27H30F3N5O3S/c1-15(2)35-13-26(8-21(35)12-38-26)14-37-22-6-18(5-19(7-22)24-31-9-16(3)39-24)23(36)34-17(4)20-10-32-25(33-11-20)27(28,29)30/h5-7,9-11,15,17,21H,8,12-14H2,1-4H3,(H,34,36)/t17-,21?,26?/m1/s1 YPUYZHJKGABFEF-XJNIYMOYSA-N 320238 3-[(5-isopropyl-2- oxa-5-azabicyclo [2.2.1]hept-1-yl) methoxy]-5- (5-methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide, as a mixture of 2 diastereoisomers::US10174016, Example 405::US10202369, Example 405::US10472354, Example 405 P2X purinoceptor 3 Homo sapiens 17.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320238 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320238&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397496 384223510 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843250 C[C@@H](NC(=O)c1cc(OCC23CC(CO2)N(C)C3)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C25H26F3N5O3S/c1-14-8-29-22(37-14)17-4-16(5-20(6-17)35-13-24-7-19(11-36-24)33(3)12-24)21(34)32-15(2)18-9-30-23(31-10-18)25(26,27)28/h4-6,8-10,15,19H,7,11-13H2,1-3H3,(H,32,34)/t15-,19?,24?/m1/s1 QZIIXNSQPLEQAW-QOFOLWBBSA-N 320239 3-[(5-methyl-2- oxa-5-azabicyclo [2.2.1]hept-1-yl) methoxy]-5- (5-methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide, as a mixture of 2 diastereoisomers::US10174016, Example 406::US10202369, Example 406::US10472354, Example 406 P2X purinoceptor 3 Homo sapiens 26.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320239 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320239&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397318 384223511 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843252 C[C@@H](NC(=O)c1cc(OCC23CNC(CO2)C3)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H24F3N5O3S/c1-13-7-28-21(36-13)16-3-15(4-19(5-16)34-12-23-6-18(10-35-23)31-11-23)20(33)32-14(2)17-8-29-22(30-9-17)24(25,26)27/h3-5,7-9,14,18,31H,6,10-12H2,1-2H3,(H,32,33)/t14-,18?,23?/m1/s1 NAZJZFLNXXGFCR-IHDUPTFDSA-N 320240 3-(5-Methyl-1,3-thiazol-2-yl)-5-[2-oxa-5-azabicyclo[2.2.1]hept-1-ylmethoxy]-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide, as a Mixture of 2 Diastereoisomers::US10174016, Example 407::US10202369, Example 407::US10472354, Example 407 P2X purinoceptor 3 Homo sapiens 15.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320240 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320240&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397648 384223512 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843254 CCCN1CC2(COc3cc(cc(c3)-c3ncc(C)s3)C(=O)N[C@H](C)c3cnc(nc3)C(F)(F)F)CC1CO2 InChI=1S/C27H30F3N5O3S/c1-4-5-35-14-26(9-21(35)13-38-26)15-37-22-7-18(6-19(8-22)24-31-10-16(2)39-24)23(36)34-17(3)20-11-32-25(33-12-20)27(28,29)30/h6-8,10-12,17,21H,4-5,9,13-15H2,1-3H3,(H,34,36)/t17-,21?,26?/m1/s1 AAPJJGZIWGLKBD-XJNIYMOYSA-N 320241 3-(5-methyl-1,3- thiazol-2-yl)-5-[(5- propyl-2- oxa-5-azabicyclo [2.2.1]hept-1-yl) methoxy]-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide, as a mixture of 2 diastereoisomers::US10174016, Example 408::US10202369, Example 408::US10472354, Example 408 P2X purinoceptor 3 Homo sapiens 32.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320241 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320241&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397789 384223513 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843256 COC(=O)N1CC2(COc3cc(cc(c3)-c3ncc(C)s3)C(=O)N[C@H](C)c3cnc(nc3)C(F)(F)F)CC1CO2 InChI=1S/C26H26F3N5O5S/c1-14-8-30-22(40-14)17-4-16(21(35)33-15(2)18-9-31-23(32-10-18)26(27,28)29)5-20(6-17)38-13-25-7-19(11-39-25)34(12-25)24(36)37-3/h4-6,8-10,15,19H,7,11-13H2,1-3H3,(H,33,35)/t15-,19?,25?/m1/s1 ACUSXDHHFJWBEG-QYRGRQSGSA-N 320242 Methyl 1-{[3-(5-methyl-1,3-thiazol-2-yl)-5-({(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}carbamoyl)phenoxy]methyl}-2-oxa-5-azabicyclo[2.2.1]heptane-5-carboxylate, as a mixture of 2 diastereoisomers::US10174016, Example 409::US10202369, Example 409::US10472354, Example 409 P2X purinoceptor 3 Homo sapiens 22.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320242 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320242&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397200 384223514 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843258 CCOC(=O)N1CC2(COc3cc(cc(c3)-c3ncc(C)s3)C(=O)N[C@H](C)c3cnc(nc3)C(F)(F)F)CC1CO2 InChI=1S/C27H28F3N5O5S/c1-4-38-25(37)35-13-26(8-20(35)12-40-26)14-39-21-6-17(5-18(7-21)23-31-9-15(2)41-23)22(36)34-16(3)19-10-32-24(33-11-19)27(28,29)30/h5-7,9-11,16,20H,4,8,12-14H2,1-3H3,(H,34,36)/t16-,20?,26?/m1/s1 MVNNYWBQRAUUBD-ORALUJHKSA-N 320243 Ethyl 1-{[3-(5-methyl-1,3-thiazol-2-yl)-5-({(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}carbamoyl)phenoxy]methyl}-2-oxa-5-azabicyclo[2.2.1]heptane-5-carboxylate, as a Mixture of 2 Diastereoisomers::US10174016, Example 410::US10202369, Example 410::US10472354, Example 410 P2X purinoceptor 3 Homo sapiens 22.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320243 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320243&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397180 384223515 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843260 CCN1CCO[C@H](COc2cc(cc(c2)-c2ncc(C)s2)C(=O)N[C@H](C)c2cnc(nc2)C(F)(F)F)C1 InChI=1S/C25H28F3N5O3S/c1-4-33-5-6-35-21(13-33)14-36-20-8-17(7-18(9-20)23-29-10-15(2)37-23)22(34)32-16(3)19-11-30-24(31-12-19)25(26,27)28/h7-12,16,21H,4-6,13-14H2,1-3H3,(H,32,34)/t16-,21+/m1/s1 IJXNJADLTIUKEL-IERDGZPVSA-N 320244 3-{[(2S)-4-ethylmorpholin-2-yl]methoxy}-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 411::US10202369, Example 411::US10472354, Example 411 P2X purinoceptor 3 Homo sapiens 20.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320244 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320244&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397533 384223516 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843262 C[C@@H](NC(=O)c1cc(OC[C@H]2CN(CCO2)C(=O)OC(C)(C)C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C28H32F3N5O5S/c1-16-11-32-24(42-16)19-8-18(23(37)35-17(2)20-12-33-25(34-13-20)28(29,30)31)9-21(10-19)40-15-22-14-36(6-7-39-22)26(38)41-27(3,4)5/h8-13,17,22H,6-7,14-15H2,1-5H3,(H,35,37)/t17-,22-/m1/s1 OEKUZTDVCYAZBS-VGOFRKELSA-N 320179 Tert-butyl (2R)-2-{[3-(5-methyl-1,3-thiazol-2-yl)-5-({(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}carbamoyl)phenoxy]methyl}morpholine-4-carboxylate::US10174016, Example 346::US10202369, Example 346::US10472354, Example 346 P2X purinoceptor 3 Homo sapiens 687 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320179 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320179&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134338449 384223452 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843264 C[C@H](NC(=O)c1cc(OC[C@H]2CNCCO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H24F3N5O3S/c1-13-8-28-21(35-13)16-5-15(6-18(7-16)34-12-19-11-27-3-4-33-19)20(32)31-14(2)17-9-29-22(30-10-17)23(24,25)26/h5-10,14,19,27H,3-4,11-12H2,1-2H3,(H,31,32)/t14-,19+/m0/s1 HRVUBTPQOQIHTK-IFXJQAMLSA-N 320246 3-(5-methyl- 1,3-thiazol-2- yl)-5-[(2R)- morpholin-2- ylmethoxy]-N- {(1S)-1-[2- (trifluoromethyl) pyrimidin-5-yl] ethyl}benzamide::US10174016, Example 413::US10202369, Example 413::US10472354, Example 413 P2X purinoceptor 3 Homo sapiens 597 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320246 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320246&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397518 384223518 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843266 CCc1cnc(s1)-c1cc(OC[C@@H]2CNCCO2)cc(c1)C(=O)N[C@H](C)c1ccc(nn1)C(F)(F)F InChI=1S/C24H26F3N5O3S/c1-3-19-12-29-23(36-19)16-8-15(9-17(10-16)35-13-18-11-28-6-7-34-18)22(33)30-14(2)20-4-5-21(32-31-20)24(25,26)27/h4-5,8-10,12,14,18,28H,3,6-7,11,13H2,1-2H3,(H,30,33)/t14-,18+/m1/s1 PAVCMPZQEBSSQV-KDOFPFPSSA-N 320247 3-(5-ethyl-1,3- thiazol-2-yl)-5- [(2S)- morpholin-2- ylmethoxy]-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3-yl] ethyl}benzamide::US10174016, Example 414::US10202369, Example 414::US10472354, Example 414 P2X purinoceptor 3 Homo sapiens 29.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320247 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320247&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397150 384223519 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843268 CCc1cnc(s1)-c1cc(OC[C@H]2CNCCO2)cc(c1)C(=O)N[C@H](C)c1ccc(nn1)C(F)(F)F InChI=1S/C24H26F3N5O3S/c1-3-19-12-29-23(36-19)16-8-15(9-17(10-16)35-13-18-11-28-6-7-34-18)22(33)30-14(2)20-4-5-21(32-31-20)24(25,26)27/h4-5,8-10,12,14,18,28H,3,6-7,11,13H2,1-2H3,(H,30,33)/t14-,18-/m1/s1 PAVCMPZQEBSSQV-RDTXWAMCSA-N 320248 3-(5-ethyl-1,3- thiazol-2-yl)-5- [(2R)- morpholin-2- ylmethoxy]-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3-yl] ethyl}benzamide::US10174016, Example 415::US10202369, Example 415::US10472354, Example 415 P2X purinoceptor 3 Homo sapiens 10.00 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320248 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320248&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397550 384223520 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843270 C[C@H](NC(=O)c1cc(OC[C@H]2CN(C)CCO2)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F InChI=1S/C24H26F3N5O3S/c1-14-11-28-23(36-14)17-8-16(9-18(10-17)35-13-19-12-32(3)6-7-34-19)22(33)29-15(2)20-4-5-21(31-30-20)24(25,26)27/h4-5,8-11,15,19H,6-7,12-13H2,1-3H3,(H,29,33)/t15-,19+/m0/s1 IJFKDPNABTXGCF-HNAYVOBHSA-N 420355 3-{[(2R)-4- methylmorpholin- 2-yl]methoxy}-5- (5-methyl-1,3- thiazol-2-yl)- N-{(1S)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10472354, Example 416 P2X purinoceptor 3 Homo sapiens 227 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=420355 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=420355&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843272 C[C@H](NC(=O)c1cc(OC[C@@H]2CN(C)CCO2)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F InChI=1S/C24H26F3N5O3S/c1-14-11-28-23(36-14)17-8-16(9-18(10-17)35-13-19-12-32(3)6-7-34-19)22(33)29-15(2)20-4-5-21(31-30-20)24(25,26)27/h4-5,8-11,15,19H,6-7,12-13H2,1-3H3,(H,29,33)/t15-,19-/m0/s1 IJFKDPNABTXGCF-KXBFYZLASA-N 420356 3-{[(2S)-4- methylmorpholin- 2-yl]methoxy}-5- (5-methyl-1,3- thiazol-2-yl)- N-{(1S)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10472354, Example 417 P2X purinoceptor 3 Homo sapiens 434 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=420356 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=420356&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843274 CCc1cnc(s1)-c1cc(OC[C@@H]2CN(C)CCO2)cc(c1)C(=O)N[C@H](C)c1ccc(nn1)C(F)(F)F InChI=1S/C25H28F3N5O3S/c1-4-20-12-29-24(37-20)17-9-16(10-18(11-17)36-14-19-13-33(3)7-8-35-19)23(34)30-15(2)21-5-6-22(32-31-21)25(26,27)28/h5-6,9-12,15,19H,4,7-8,13-14H2,1-3H3,(H,30,34)/t15-,19+/m1/s1 SIFMRPZFMXLARV-BEFAXECRSA-N 322607 3-(5-Ethyl-1,3- thiazol-2-yl)-5- {[(2S)-4- methyl- morpholin-2- yl]methoxy}-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl} benzamide::US10183937, Example 418::US10202369, Example 418::US10472354, Example 418 P2X purinoceptor 3 Homo sapiens 23.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322607 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322607&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397330 384225667 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843276 CCc1cnc(s1)-c1cc(OC[C@H]2CN(C)CCO2)cc(c1)C(=O)N[C@H](C)c1ccc(nn1)C(F)(F)F InChI=1S/C25H28F3N5O3S/c1-4-20-12-29-24(37-20)17-9-16(10-18(11-17)36-14-19-13-33(3)7-8-35-19)23(34)30-15(2)21-5-6-22(32-31-21)25(26,27)28/h5-6,9-12,15,19H,4,7-8,13-14H2,1-3H3,(H,30,34)/t15-,19-/m1/s1 SIFMRPZFMXLARV-DNVCBOLYSA-N 322608 3-(5-ethyl-1,3- thiazol-2-yl)-5- {[(2R)-4- methyl- morpholin-2- yl]methoxy}-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl} benzamide::US10183937, Example 419::US10202369, Example 419::US10472354, Example 419 P2X purinoceptor 3 Homo sapiens 9.00 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322608 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322608&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397262 384225668 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842508 Cc1cnc(s1)-c1cc(OCC#C)cc(c1)C(=O)NCc1cnc(C)cn1 InChI=1S/C20H18N4O2S/c1-4-5-26-18-7-15(6-16(8-18)20-24-10-14(3)27-20)19(25)23-12-17-11-21-13(2)9-22-17/h1,6-11H,5,12H2,2-3H3,(H,23,25) HKQDCIZFKBUDQD-UHFFFAOYSA-N 319868 N-[(5- Methylpyrazin- 2-yl)methyl]- 3-(5-methyl- 1,3-thiazol-2- yl)-5-(prop-2- yn-1- yloxy)benzamide::US10174016, Example 35::US10202369, Example 35::US10472354, Example 35 P2X purinoceptor 3 Homo sapiens 460 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319868 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319868&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397704 384223148 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842510 C[C@@H](NC(=O)c1cc(OCC#C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C21H17F3N4O2S/c1-4-5-30-17-7-14(6-15(8-17)19-25-9-12(2)31-19)18(29)28-13(3)16-10-26-20(27-11-16)21(22,23)24/h1,6-11,13H,5H2,2-3H3,(H,28,29)/t13-/m1/s1 BTRSFHCVZJPJKT-CYBMUJFWSA-N 319869 3-(5-Methyl- 1,3-thiazol-2- yl)-5-(prop-2- yn-1-yloxy)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 36::US10202369, Example 36::US10472354, Example 36 P2X purinoceptor 3 Homo sapiens 14.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319869 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319869&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397309 384223149 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842512 C[C@@H](NC(=O)c1cc(OCC#C)cc(c1)-c1ncc(C)s1)c1ccc(C)nn1 InChI=1S/C21H20N4O2S/c1-5-8-27-18-10-16(9-17(11-18)21-22-12-14(3)28-21)20(26)23-15(4)19-7-6-13(2)24-25-19/h1,6-7,9-12,15H,8H2,2-4H3,(H,23,26)/t15-/m1/s1 IZIUFNSLLIEWJE-OAHLLOKOSA-N 319870 N-[(1R)-1-(6- Methylpyridazin- 3-yl)ethyl]- 3-(5-methyl- 1,3-thiazol-2- yl)-5-(prop-2- yn-1- yloxy) benzamide::US10174016, Example 37::US10202369, Example 37::US10472354, Example 37 P2X purinoceptor 3 Homo sapiens 55.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319870 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319870&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397261 384223150 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842514 C[C@@H](NC(=O)c1cc(OCC#C)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F InChI=1S/C21H17F3N4O2S/c1-4-7-30-16-9-14(8-15(10-16)20-25-11-12(2)31-20)19(29)26-13(3)17-5-6-18(28-27-17)21(22,23)24/h1,5-6,8-11,13H,7H2,2-3H3,(H,26,29)/t13-/m1/s1 PNZFOFJAUOCDQW-CYBMUJFWSA-N 319871 3-(5-Methyl- 1,3-thiazol-2- yl)-5-(prop-2- yn-1-yloxy)-N- [(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl] benzamide::US10174016, Example 38::US10202369, Example 38::US10472354, Example 38 P2X purinoceptor 3 Homo sapiens 55.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319871 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319871&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397333 384223151 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842516 C[C@@H](NC(=O)c1cc(OCC#C)cc(c1)-c1ncc(C)s1)c1cnc(C)nc1 InChI=1S/C21H20N4O2S/c1-5-6-27-19-8-16(7-17(9-19)21-24-10-13(2)28-21)20(26)25-14(3)18-11-22-15(4)23-12-18/h1,7-12,14H,6H2,2-4H3,(H,25,26)/t14-/m1/s1 OVENJFXCZONLOP-CQSZACIVSA-N 319872 N-[(1R)-1-(2- Methylpyrimidin- 5-yl)ethyl]- 3-(5-methyl- 1,3-thiazol-2- yl)-5-(prop-2- yn-1- yloxy) benzamide::US10174016, Example 39::US10202369, Example 39::US10472354, Example 39 P2X purinoceptor 3 Homo sapiens 81.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319872 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319872&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397588 384223152 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842518 CC#CCOc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C22H19F3N4O2S/c1-4-5-6-31-18-8-15(7-16(9-18)20-26-10-13(2)32-20)19(30)29-14(3)17-11-27-21(28-12-17)22(23,24)25/h7-12,14H,6H2,1-3H3,(H,29,30)/t14-/m1/s1 XSZOYFWYESZINQ-CQSZACIVSA-N 319873 3-(But-2-yn-1- yloxy)-5-(5- methyl-1,3- thiazol-2-yl)- N-[(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl] benzamide::US10174016, Example 40::US10202369, Example 40::US10472354, Example 40 P2X purinoceptor 3 Homo sapiens 16.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319873 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319873&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397357 384223153 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842520 CC#CCOc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1nnc(C)s1 InChI=1S/C20H20N4O2S2/c1-5-6-7-26-17-9-15(8-16(10-17)20-21-11-12(2)27-20)18(25)22-13(3)19-24-23-14(4)28-19/h8-11,13H,7H2,1-4H3,(H,22,25)/t13-/m1/s1 ORWZAOZYNYEGDS-CYBMUJFWSA-N 319874 3-(But-2-yn-1- yloxy)-N-[(1R)- 1-(5-methyl- 1,3,4- thiadiazol-2- yl)ethyl]-5-(5- methyl-1,3- thiazol-2- yl)benzamide::US10174016, Example 41::US10202369, Example 41::US10472354, Example 41 P2X purinoceptor 3 Homo sapiens 130 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319874 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319874&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397286 384223154 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842522 C[C@@H](NC(=O)c1cc(OC2COC2)cc(c1)-c1ncc(C)s1)c1cnc(C)cn1 InChI=1S/C21H22N4O3S/c1-12-7-23-19(9-22-12)14(3)25-20(26)15-4-16(21-24-8-13(2)29-21)6-17(5-15)28-18-10-27-11-18/h4-9,14,18H,10-11H2,1-3H3,(H,25,26)/t14-/m1/s1 AWWAAAATSKEOQH-CQSZACIVSA-N 319875 N-[(1R)-1-(5-Methylpyrazin-2-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-(oxetan-3-yloxy)benzamide::US10174016, Example 42::US10202369, Example 42::US10472354, Example 42 P2X purinoceptor 3 Homo sapiens 129 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319875 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319875&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397394 384223155 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842524 C[C@@H](NC(=O)c1cc(OC2COC2)cc(c1)-c1ncc(C)s1)c1cnc(C)nc1 InChI=1S/C21H22N4O3S/c1-12-7-24-21(29-12)16-4-15(5-18(6-16)28-19-10-27-11-19)20(26)25-13(2)17-8-22-14(3)23-9-17/h4-9,13,19H,10-11H2,1-3H3,(H,25,26)/t13-/m1/s1 QZYMXYIOESSIBG-CYBMUJFWSA-N 319876 N-[(1R)-1-(2-Methylpyrimidin-5-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-(oxetan-3-yloxy)benzamide::US10174016, Example 43::US10202369, Example 43::US10472354, Example 43 P2X purinoceptor 3 Homo sapiens 50.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319876 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319876&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397750 384223156 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842526 CC(NC(=O)c1cc(OC2COC2)cc(c1)-c1ncc(C)s1)c1ncc(Cl)cc1F InChI=1S/C21H19ClFN3O3S/c1-11-7-25-21(30-11)14-3-13(4-16(5-14)29-17-9-28-10-17)20(27)26-12(2)19-18(23)6-15(22)8-24-19/h3-8,12,17H,9-10H2,1-2H3,(H,26,27) DXVSMJSLGFWBSV-UHFFFAOYSA-N 319877 N-[1-(5-Chloro-3-fluoropyridin-2-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-(oxetan-3-yloxy)benzamide::US10174016, Example 44::US10202369, Example 44::US10472354, Example 44 P2X purinoceptor 3 Homo sapiens 11.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319877 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319877&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397182 384223157 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842528 Cc1cnc(s1)-c1cc(OC2COC2)cc(c1)C(=O)NCc1ccc(C)nn1 InChI=1S/C20H20N4O3S/c1-12-3-4-16(24-23-12)9-21-19(25)14-5-15(20-22-8-13(2)28-20)7-17(6-14)27-18-10-26-11-18/h3-8,18H,9-11H2,1-2H3,(H,21,25) AFIPEIBYSBBLBJ-UHFFFAOYSA-N 319878 N-[(6-Methylpyridazin-3-yl)methyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-(oxetan-3-yloxy)benzamide::US10174016, Example 45::US10202369, Example 45::US10472354, Example 45 P2X purinoceptor 3 Homo sapiens 212 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319878 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319878&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397740 384223158 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842530 C[C@@H](NC(=O)c1cc(OC2COC2)cc(c1)-c1ncc(C)s1)c1ccc(Cl)cn1 InChI=1S/C21H20ClN3O3S/c1-12-8-24-21(29-12)15-5-14(6-17(7-15)28-18-10-27-11-18)20(26)25-13(2)19-4-3-16(22)9-23-19/h3-9,13,18H,10-11H2,1-2H3,(H,25,26)/t13-/m1/s1 FFCGGIUVAQWIMW-CYBMUJFWSA-N 319879 N-[(1R)-1-(5-Chloropyridin-2-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-(oxetan-3-yloxy)benzamide::US10174016, Example 46::US10202369, Example 46::US10472354, Example 46 P2X purinoceptor 3 Homo sapiens 10.00 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319879 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319879&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397660 384223159 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842532 C[C@@H](NC(=O)c1cc(OC2COC2)cc(c1)-c1ncc(C)s1)c1ccc(C)nn1 InChI=1S/C21H22N4O3S/c1-12-4-5-19(25-24-12)14(3)23-20(26)15-6-16(21-22-9-13(2)29-21)8-17(7-15)28-18-10-27-11-18/h4-9,14,18H,10-11H2,1-3H3,(H,23,26)/t14-/m1/s1 HFDOVXXFUCEVBK-CQSZACIVSA-N 319880 N-[(1R)-1-(6-Methylpyridazin-3-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-(oxetan-3-yloxy)benzamide::US10174016, Example 47::US10202369, Example 47::US10472354, Example 47 P2X purinoceptor 3 Homo sapiens 82.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319880&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397352 384223160 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842534 C[C@@H](NC(=O)c1cc(OC2COC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C21H19F3N4O3S/c1-11-6-25-19(32-11)14-3-13(4-16(5-14)31-17-9-30-10-17)18(29)28-12(2)15-7-26-20(27-8-15)21(22,23)24/h3-8,12,17H,9-10H2,1-2H3,(H,28,29)/t12-/m1/s1 HXNSKECKPLVRIH-GFCCVEGCSA-N 319881 3-(5-Methyl-1,3-thiazol-2-yl)-5-(oxetan-3-yloxy)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 48::US10202369, Example 48::US10472354, Example 48 P2X purinoceptor 3 Homo sapiens 14.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319881 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319881&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397291 384223161 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842536 CC(NC(=O)c1cc(OC2COC2)cc(c1)-c1ncc(C)s1)c1ncc(F)cc1Cl InChI=1S/C21H19ClFN3O3S/c1-11-7-25-21(30-11)14-3-13(4-16(5-14)29-17-9-28-10-17)20(27)26-12(2)19-18(22)6-15(23)8-24-19/h3-8,12,17H,9-10H2,1-2H3,(H,26,27) FNMVOFQACWEVTO-UHFFFAOYSA-N 319882 N-[1-(3-Chloro-5-fluoropyridin-2-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-(oxetan-3-yloxy)benzamide::US10174016, Example 49::US10202369, Example 49::US10472354, Example 49 P2X purinoceptor 3 Homo sapiens 132 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319882 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319882&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397320 384223162 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842538 C[C@@H](NC(=O)c1cc(OC2COC2)cc(c1)C1=[S]C=C(C)N1)c1nnc(C)s1 InChI=1S/C19H21N4O3S2/c1-10-9-27-19(20-10)14-4-13(5-15(6-14)26-16-7-25-8-16)17(24)21-11(2)18-23-22-12(3)28-18/h4-6,9,11,16,20H,7-8H2,1-3H3,(H,21,24)/t11-/m1/s1 VNOLWUXOQFRHOP-LLVKDONJSA-N 419970 US10472354, Example 50 P2X purinoceptor 3 Homo sapiens 77.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=419970 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=419970&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842540 C[C@@H](NC(=O)c1cc(OC2COC2)cc(c1)C1=[S]C(C)=CN1)c1ccc(C)nc1 InChI=1S/C22H24N3O3S/c1-13-4-5-16(10-23-13)15(3)25-21(26)17-6-18(22-24-9-14(2)29-22)8-19(7-17)28-20-11-27-12-20/h4-10,15,20,24H,11-12H2,1-3H3,(H,25,26)/t15-/m1/s1 GAVXGHHYABXHOQ-OAHLLOKOSA-N 419971 US10472354, Example 51 P2X purinoceptor 3 Homo sapiens 74.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=419971 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=419971&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842542 Cc1cnc(s1)-c1cc(OC2COC2)cc(c1)C(=O)NCc1ccc(nn1)C(F)(F)F InChI=1S/C20H17F3N4O3S/c1-11-7-25-19(31-11)13-4-12(5-15(6-13)30-16-9-29-10-16)18(28)24-8-14-2-3-17(27-26-14)20(21,22)23/h2-7,16H,8-10H2,1H3,(H,24,28) KTKYNBLLOZOZPY-UHFFFAOYSA-N 319885 3-(5-Methyl- 1,3-thiazol-2- yl)-5-(oxetan- 3-yloxy)-N-{[6- (trifluoromethyl) pyridazin-3- yl]methyl} benzamide::US10174016, Example 52::US10202369, Example 52::US10472354, Example 52 P2X purinoceptor 3 Homo sapiens 194 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319885 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319885&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397650 384223165 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842544 CC[C@@H](NC(=O)c1cc(OC2COC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C22H21F3N4O3S/c1-3-18(15-8-27-21(28-9-15)22(23,24)25)29-19(30)13-4-14(20-26-7-12(2)33-20)6-16(5-13)32-17-10-31-11-17/h4-9,17-18H,3,10-11H2,1-2H3,(H,29,30)/t18-/m1/s1 PHCWFMJDVHAVQT-GOSISDBHSA-N 319886 3-(5-Methyl- 1,3-thiazol-2- yl)-5-(oxetan- 3-yloxy)-N- [(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]propyl] benzamide::US10174016, Example 53::US10202369, Example 53::US10472354, Example 53 P2X purinoceptor 3 Homo sapiens 318 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319886 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319886&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397526 384223166 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842546 Cc1cnc(s1)-c1cc(OC[C@@H]2CCCO2)cc(c1)C(=O)NCc1ccc(C)nn1 InChI=1S/C22H24N4O3S/c1-14-5-6-18(26-25-14)12-23-21(27)16-8-17(22-24-11-15(2)30-22)10-20(9-16)29-13-19-4-3-7-28-19/h5-6,8-11,19H,3-4,7,12-13H2,1-2H3,(H,23,27)/t19-/m0/s1 IFCRFQDQDLUKDL-IBGZPJMESA-N 319887 N-[(6-Methylpyridazin-3-yl)methyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(2S)-tetrahydrofuran-2-ylmethoxy]benzamide::US10174016, Example 54::US10202369, Example 54::US10472354, Example 54 P2X purinoceptor 3 Homo sapiens 66.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319887 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319887&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397485 384223167 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842548 CC1=CNC(=[S]1)c1cc(OC[C@@H]2CCCO2)cc(c1)C(=O)NCc1ncc(Cl)cc1F InChI=1S/C22H22ClFN3O3S/c1-13-9-27-22(31-13)15-5-14(6-18(7-15)30-12-17-3-2-4-29-17)21(28)26-11-20-19(24)8-16(23)10-25-20/h5-10,17,27H,2-4,11-12H2,1H3,(H,26,28)/t17-/m0/s1 ALVAUYIPIZELRY-KRWDZBQOSA-N 419975 US10472354, Example 55 P2X purinoceptor 3 Homo sapiens 8.00 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=419975 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=419975&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842550 CC1=CNC(=[S]1)c1cc(OC[C@@H]2CCCO2)cc(c1)C(=O)NCc1cnc(C)cn1 InChI=1S/C22H25N4O3S/c1-14-9-24-18(11-23-14)12-25-21(27)16-6-17(22-26-10-15(2)30-22)8-20(7-16)29-13-19-4-3-5-28-19/h6-11,19,26H,3-5,12-13H2,1-2H3,(H,25,27)/t19-/m0/s1 UAHUKPQUPXOADJ-IBGZPJMESA-N 419976 US10472354, Example 56 P2X purinoceptor 3 Homo sapiens 148 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=419976 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=419976&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842552 C[C@@H](NC(=O)c1cc(OC[C@@H]2CCCO2)cc(c1)-c1ncc(C)s1)c1cnc(C)cn1 InChI=1S/C23H26N4O3S/c1-14-10-25-21(12-24-14)16(3)27-22(28)17-7-18(23-26-11-15(2)31-23)9-20(8-17)30-13-19-5-4-6-29-19/h7-12,16,19H,4-6,13H2,1-3H3,(H,27,28)/t16-,19+/m1/s1 MANPQCKCYFRFOG-APWZRJJASA-N 319890 N-[(1R)-1-(5-Methylpyrazin-2-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(2S)-tetrahydrofuran-2-ylmethoxy]benzamide::US10174016, Example 57::US10202369, Example 57::US10472354, Example 57 P2X purinoceptor 3 Homo sapiens 25.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319890 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319890&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397390 384223170 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842554 C[C@@H](NC(=O)c1cc(OC[C@@H]2CCCO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H23F3N4O3S/c1-13-9-27-21(34-13)16-6-15(7-19(8-16)33-12-18-4-3-5-32-18)20(31)30-14(2)17-10-28-22(29-11-17)23(24,25)26/h6-11,14,18H,3-5,12H2,1-2H3,(H,30,31)/t14-,18+/m1/s1 MXZPUDRHAAYJOR-KDOFPFPSSA-N 319891 3-(5-Methyl-1,3-thiazol-2-yl)-5-[(2S)-tetrahydrofuran-2-ylmethoxy]-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 58::US10202369, Example 58::US10472354, Example 58 P2X purinoceptor 3 Homo sapiens 4.00 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319891 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319891&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397134 384223171 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842556 C[C@@H](NC(=O)c1cc(OC[C@@H]2CCCO2)cc(c1)-c1ncc(C)s1)c1ccc(C)nn1 InChI=1S/C23H26N4O3S/c1-14-6-7-21(27-26-14)16(3)25-22(28)17-9-18(23-24-12-15(2)31-23)11-20(10-17)30-13-19-5-4-8-29-19/h6-7,9-12,16,19H,4-5,8,13H2,1-3H3,(H,25,28)/t16-,19+/m1/s1 JHPJVAOLQKHAFN-APWZRJJASA-N 319892 N-[(1R)-1-(6-Methylpyridazin-3-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(2S)-tetrahydrofuran-2-ylmethoxy]benzamide::US10174016, Example 59::US10202369, Example 59::US10472354, Example 59 P2X purinoceptor 3 Homo sapiens 13.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319892 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319892&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397721 384223172 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842558 C[C@@H](NC(=O)c1cc(OC[C@@H]2CCCO2)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F InChI=1S/C23H23F3N4O3S/c1-13-11-27-22(34-13)16-8-15(9-18(10-16)33-12-17-4-3-7-32-17)21(31)28-14(2)19-5-6-20(30-29-19)23(24,25)26/h5-6,8-11,14,17H,3-4,7,12H2,1-2H3,(H,28,31)/t14-,17+/m1/s1 KNJYTDFISMIFTK-PBHICJAKSA-N 319893 3-(5-Methyl-1,3-thiazol-2-yl)-5-[(2S)-tetrahydrofuran-2-ylmethoxy]-N-{(1R)-1-[6-(trifluoromethyl)pyridazin-3-yl]ethyl}benzamide::US10174016, Example 60::US10202369, Example 60::US10472354, Example 60 P2X purinoceptor 3 Homo sapiens 11.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319893 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319893&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397124 384223173 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842560 C[C@@H](NC(=O)c1cc(OC[C@H]2CCCO2)cc(c1)-c1ncc(C)s1)c1ccc(C)nn1 InChI=1S/C23H26N4O3S/c1-14-6-7-21(27-26-14)16(3)25-22(28)17-9-18(23-24-12-15(2)31-23)11-20(10-17)30-13-19-5-4-8-29-19/h6-7,9-12,16,19H,4-5,8,13H2,1-3H3,(H,25,28)/t16-,19-/m1/s1 JHPJVAOLQKHAFN-VQIMIIECSA-N 319894 N-[(1R)-1-(6-methylpyridazin-3-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(2R)-tetrahydrofuran-2-ylmethoxy]benzamide::US10174016, Example 61::US10202369, Example 61::US10472354, Example 61 P2X purinoceptor 3 Homo sapiens 14.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319894 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319894&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397475 384223174 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842562 Cc1cnc(s1)-c1cc(OC[C@H]2CCCO2)cc(c1)C(=O)NCc1ccc(C)nn1 InChI=1S/C22H24N4O3S/c1-14-5-6-18(26-25-14)12-23-21(27)16-8-17(22-24-11-15(2)30-22)10-20(9-16)29-13-19-4-3-7-28-19/h5-6,8-11,19H,3-4,7,12-13H2,1-2H3,(H,23,27)/t19-/m1/s1 IFCRFQDQDLUKDL-LJQANCHMSA-N 319895 N-[(6-Methylpyridazin-3-yl)methyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(2R)-tetrahydrofuran-2-ylmethoxy]benzamide::US10174016, Example 62::US10202369, Example 62::US10472354, Example 62 P2X purinoceptor 3 Homo sapiens 85.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319895 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319895&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397725 384223175 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842564 C[C@@H](NC(=O)c1cc(OC[C@H]2CCCO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H23F3N4O3S/c1-13-9-27-21(34-13)16-6-15(7-19(8-16)33-12-18-4-3-5-32-18)20(31)30-14(2)17-10-28-22(29-11-17)23(24,25)26/h6-11,14,18H,3-5,12H2,1-2H3,(H,30,31)/t14-,18-/m1/s1 MXZPUDRHAAYJOR-RDTXWAMCSA-N 319896 3-(5-Methyl-1,3-thiazol-2-yl)-5-[(2R)-tetrahydrofuran-2-ylmethoxy]-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 63::US10202369, Example 63::US10472354, Example 63 P2X purinoceptor 3 Homo sapiens 4.00 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319896 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319896&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397292 384223176 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842566 C[C@@H](NC(=O)c1cc(OC[C@H]2CCCO2)cc(c1)-c1ncc(C)s1)c1cnc(C)cn1 InChI=1S/C23H26N4O3S/c1-14-10-25-21(12-24-14)16(3)27-22(28)17-7-18(23-26-11-15(2)31-23)9-20(8-17)30-13-19-5-4-6-29-19/h7-12,16,19H,4-6,13H2,1-3H3,(H,27,28)/t16-,19-/m1/s1 MANPQCKCYFRFOG-VQIMIIECSA-N 319897 N-[(1R)-1-(5-methylpyrazin-2-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(2R)-tetrahydrofuran-2-ylmethoxy]benzamide::US10174016, Example 64::US10202369, Example 64::US10472354, Example 64 P2X purinoceptor 3 Homo sapiens 53.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319897 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319897&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397244 384223177 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842568 CC(NC(=O)c1cc(OC[C@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ncc(Cl)cc1F InChI=1S/C23H23ClFN3O3S/c1-13-9-27-23(32-13)17-5-16(6-19(7-17)31-12-15-3-4-30-11-15)22(29)28-14(2)21-20(25)8-18(24)10-26-21/h5-10,14-15H,3-4,11-12H2,1-2H3,(H,28,29)/t14?,15-/m0/s1 NHGFOVVSFOISFI-LOACHALJSA-N 319898 N-[1-(5- Chloro-3- fluoropyridin- 2-yl)ethyl]-3- (5-methyL- 1,3-thiazol-2- yl)-5-[(3S)- tetrahydrofuran- 3-ylmethoxy] benzamide::US10174016, Example 65::US10202369, Example 65::US10472354, Example 65 P2X purinoceptor 3 Homo sapiens 3.00 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319898 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319898&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397187 384223178 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842570 Cc1cnc(s1)-c1cc(OC[C@H]2CCOC2)cc(c1)C(=O)NCc1ccc(C)nn1 InChI=1S/C22H24N4O3S/c1-14-3-4-19(26-25-14)11-23-21(27)17-7-18(22-24-10-15(2)30-22)9-20(8-17)29-13-16-5-6-28-12-16/h3-4,7-10,16H,5-6,11-13H2,1-2H3,(H,23,27)/t16-/m0/s1 SKNHRCMFBDROGE-INIZCTEOSA-N 319899 N-[(6- Methylpyridazin- 3-yl)methyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5-[(3S)- tetrahydrofuran- 3-ylmethoxy] benzamide::US10174016, Example 66::US10202369, Example 66::US10472354, Example 66 P2X purinoceptor 3 Homo sapiens 35.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319899 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319899&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397153 384223179 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842572 Cc1cnc(s1)-c1cc(OC[C@H]2CCOC2)cc(c1)C(=O)NCc1cnc(C)cn1 InChI=1S/C22H24N4O3S/c1-14-8-24-19(10-23-14)11-25-21(27)17-5-18(22-26-9-15(2)30-22)7-20(6-17)29-13-16-3-4-28-12-16/h5-10,16H,3-4,11-13H2,1-2H3,(H,25,27)/t16-/m0/s1 MFTNZVDLSIJVDH-INIZCTEOSA-N 319900 N-[(5- Methylpyrazin- 2-yl)methyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5-[(3S)- tetrahydrofuran- 3-ylmethoxy] benzamide::US10174016, Example 67::US10202369, Example 67::US10472354, Example 67 P2X purinoceptor 3 Homo sapiens 186 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319900 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319900&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397127 384223180 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842574 C[C@@H](NC(=O)c1cc(OC[C@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1cnc(C)cn1 InChI=1S/C23H26N4O3S/c1-14-9-25-21(11-24-14)16(3)27-22(28)18-6-19(23-26-10-15(2)31-23)8-20(7-18)30-13-17-4-5-29-12-17/h6-11,16-17H,4-5,12-13H2,1-3H3,(H,27,28)/t16-,17+/m1/s1 VCKXOWQZUNTNDF-SJORKVTESA-N 319901 N-[(1R)-1-(5- Methylpyrazin- 2-yl)ethyl]- 3-(5-methyl- 1,3-thiazol-2- yl)-5-[(3S)- tetrahydrofuran- 3-ylmethoxy] benzamide::US10174016, Example 68::US10202369, Example 68::US10472354, Example 68 P2X purinoceptor 3 Homo sapiens 44.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319901 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319901&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397617 384223181 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842576 CC(NC(=O)c1cc(OC[C@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ncc(F)cc1Cl InChI=1S/C23H23ClFN3O3S/c1-13-9-27-23(32-13)17-5-16(6-19(7-17)31-12-15-3-4-30-11-15)22(29)28-14(2)21-20(24)8-18(25)10-26-21/h5-10,14-15H,3-4,11-12H2,1-2H3,(H,28,29)/t14?,15-/m0/s1 UNHVUPCUCRZLRC-LOACHALJSA-N 319902 N-[1-(3- Chloro-5- fluoropyridin- 2-yl)ethyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5-[(3R)- tetrahydrofuran- 3-ylmethoxy] benzamide::US10174016, Example 69::US10202369, Example 69::US10472354, Example 69 P2X purinoceptor 3 Homo sapiens 15.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319902 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319902&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134338444 384223182 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842578 C[C@@H](NC(=O)c1cc(OC[C@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H23F3N4O3S/c1-13-8-27-21(34-13)17-5-16(6-19(7-17)33-12-15-3-4-32-11-15)20(31)30-14(2)18-9-28-22(29-10-18)23(24,25)26/h5-10,14-15H,3-4,11-12H2,1-2H3,(H,30,31)/t14-,15+/m1/s1 CHPCVIFXIKJNGF-CABCVRRESA-N 319903 3-(5-Methyl- 1,3-thiazol-2- yl)-5-[(3S)- tetrahydrofuran- 3-ylmethoxy]- N-[(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl] benzamide::US10174016, Example 70::US10202369, Example 70::US10472354, Example 70 P2X purinoceptor 3 Homo sapiens 3.00 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319903 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319903&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397748 384223183 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842580 C[C@@H](NC(=O)c1cc(OC[C@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ccc(C)nn1 InChI=1S/C23H26N4O3S/c1-14-4-5-21(27-26-14)16(3)25-22(28)18-8-19(23-24-11-15(2)31-23)10-20(9-18)30-13-17-6-7-29-12-17/h4-5,8-11,16-17H,6-7,12-13H2,1-3H3,(H,25,28)/t16-,17+/m1/s1 DJBMUKYGNBBQBO-SJORKVTESA-N 319904 N-[(1R)-1-(6- Methylpyridazin- 3-yl)ethyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5-[(3S)- tetrahydrofuran- 3-ylmethoxy] benzamide::US10174016, Example 71::US10202369, Example 71::US10472354, Example 71 P2X purinoceptor 3 Homo sapiens 15.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319904 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319904&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397305 384223184 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842582 C[C@@H](NC(=O)c1cc(OC[C@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F InChI=1S/C23H23F3N4O3S/c1-13-10-27-22(34-13)17-7-16(8-18(9-17)33-12-15-5-6-32-11-15)21(31)28-14(2)19-3-4-20(30-29-19)23(24,25)26/h3-4,7-10,14-15H,5-6,11-12H2,1-2H3,(H,28,31)/t14-,15+/m1/s1 BICIIZABCQYPPY-CABCVRRESA-N 319905 3-(5-Methyl- 1,3-thiazol-2- yl)-5-[(3S)- tetrahydrofuran- 3-ylmethoxy]- N-[(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl] benzamide::US10174016, Example 72::US10202369, Example 72::US10472354, Example 72 P2X purinoceptor 3 Homo sapiens 11.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319905 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319905&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397781 384223185 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842584 C[C@@H](NC(=O)c1cc(OC[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H23F3N4O3S/c1-13-8-27-21(34-13)17-5-16(6-19(7-17)33-12-15-3-4-32-11-15)20(31)30-14(2)18-9-28-22(29-10-18)23(24,25)26/h5-10,14-15H,3-4,11-12H2,1-2H3,(H,30,31)/t14-,15-/m1/s1 CHPCVIFXIKJNGF-HUUCEWRRSA-N 319906 3-(5-Methyl- 1,3-thiazol-2- yl)-5-[(3R)- tetrahydrofuran- 3-ylmethoxy]- N-[(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl] benzamide::US10174016, Example 73::US10202369, Example 73::US10472354, Example 73 P2X purinoceptor 3 Homo sapiens 4.00 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319906 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319906&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397238 384223186 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842586 C[C@@H](NC(=O)c1cc(OC[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1cnc(C)cn1 InChI=1S/C23H26N4O3S/c1-14-9-25-21(11-24-14)16(3)27-22(28)18-6-19(23-26-10-15(2)31-23)8-20(7-18)30-13-17-4-5-29-12-17/h6-11,16-17H,4-5,12-13H2,1-3H3,(H,27,28)/t16-,17-/m1/s1 VCKXOWQZUNTNDF-IAGOWNOFSA-N 319907 N-[(1R)-1-(5- Methylpyrazin- 2-yl)ethyl]- 3-(5-methyl- 1,3-thiazol-2- yl)-5-[(3R)- tetrahydrofuran- 3-ylmethoxy] benzamide::US10174016, Example 74::US10202369, Example 74::US10472354, Example 74 P2X purinoceptor 3 Homo sapiens 14.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319907 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319907&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397532 384223187 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842588 Cc1cnc(s1)-c1cc(OC[C@@H]2CCOC2)cc(c1)C(=O)NCc1ccc(C)nn1 InChI=1S/C22H24N4O3S/c1-14-3-4-19(26-25-14)11-23-21(27)17-7-18(22-24-10-15(2)30-22)9-20(8-17)29-13-16-5-6-28-12-16/h3-4,7-10,16H,5-6,11-13H2,1-2H3,(H,23,27)/t16-/m1/s1 SKNHRCMFBDROGE-MRXNPFEDSA-N 319908 N-[(6- Methylpyridazin- 3-yl)methyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5-[(3R)- tetrahydrofuran- 3-ylmethoxy] benzamide::US10174016, Example 75::US10202369, Example 75::US10472354, Example 75 P2X purinoceptor 3 Homo sapiens 38.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319908 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319908&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397221 384223188 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842590 Cc1cnc(s1)-c1cc(OC[C@@H]2CCOC2)cc(c1)C(=O)NCc1cnc(C)cn1 InChI=1S/C22H24N4O3S/c1-14-8-24-19(10-23-14)11-25-21(27)17-5-18(22-26-9-15(2)30-22)7-20(6-17)29-13-16-3-4-28-12-16/h5-10,16H,3-4,11-13H2,1-2H3,(H,25,27)/t16-/m1/s1 MFTNZVDLSIJVDH-MRXNPFEDSA-N 319909 N-[(5- Methylpyrazin- 2-yl)methyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5-[(3R)- tetrahydrofuran- 3-ylmethoxy] benzamide::US10174016, Example 76::US10202369, Example 76::US10472354, Example 76 P2X purinoceptor 3 Homo sapiens 201 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319909 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319909&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397850 384223189 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842592 C[C@@H](NC(=O)c1cc(OC[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ccc(C)nn1 InChI=1S/C23H26N4O3S/c1-14-4-5-21(27-26-14)16(3)25-22(28)18-8-19(23-24-11-15(2)31-23)10-20(9-18)30-13-17-6-7-29-12-17/h4-5,8-11,16-17H,6-7,12-13H2,1-3H3,(H,25,28)/t16-,17-/m1/s1 DJBMUKYGNBBQBO-IAGOWNOFSA-N 319910 N-[(1R)-1-(6- Methylpyridazin- 3-yl)ethyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5-[(3R)- tetrahydrofuran- 3-ylmethoxy] benzomide::US10174016, Example 77::US10202369, Example 77::US10472354, Example 77 P2X purinoceptor 3 Homo sapiens 10.00 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319910 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319910&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397806 384223190 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842594 CC(NC(=O)c1cc(OC[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ncc(Cl)cc1F InChI=1S/C23H23ClFN3O3S/c1-13-9-27-23(32-13)17-5-16(6-19(7-17)31-12-15-3-4-30-11-15)22(29)28-14(2)21-20(25)8-18(24)10-26-21/h5-10,14-15H,3-4,11-12H2,1-2H3,(H,28,29)/t14?,15-/m1/s1 NHGFOVVSFOISFI-YSSOQSIOSA-N 319911 N-[1-(5- Chloro-3- fluoropyridin- 2-yl)ethyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5-[(3R)- tetrahydrofuran- 3-ylmethoxy] benzamide::US10174016, Example 78::US10202369, Example 78::US10472354, Example 78 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319911 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319911&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397720 384223191 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842596 C[C@@H](NC(=O)c1cc(OC[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F InChI=1S/C23H23F3N4O3S/c1-13-10-27-22(34-13)17-7-16(8-18(9-17)33-12-15-5-6-32-11-15)21(31)28-14(2)19-3-4-20(30-29-19)23(24,25)26/h3-4,7-10,14-15H,5-6,11-12H2,1-2H3,(H,28,31)/t14-,15-/m1/s1 BICIIZABCQYPPY-HUUCEWRRSA-N 319912 3-(5-Methyl- 1,3-thiazol-2- yl)-5-[(3R)- tetrahydrofuran- 3-ylmethoxy]- N-[(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl] benzamide::US10174016, Example 79::US10202369, Example 79::US10472354, Example 79 P2X purinoceptor 3 Homo sapiens 9.00 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319912 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319912&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397596 384223192 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842598 CC(NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(C)s1)c1ncc(F)cc1Cl InChI=1S/C23H23ClFN3O3S/c1-13-11-27-23(32-13)16-7-15(8-19(9-16)31-18-3-5-30-6-4-18)22(29)28-14(2)21-20(24)10-17(25)12-26-21/h7-12,14,18H,3-6H2,1-2H3,(H,28,29) SBZIYANVWYKJKX-UHFFFAOYSA-N 319913 N-[1-(3- Chloro-5- fluoropyridin- 2-yl)ethyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5- (tetrahydro- 2H-pyran-4- yloxy) benzamide::US10174016, Example 80::US10202369, Example 80::US10472354, Example 80 P2X purinoceptor 3 Homo sapiens 12.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319913 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319913&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397324 384223193 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842600 CC(NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(C)s1)c1ncc(Cl)cc1F InChI=1S/C23H23ClFN3O3S/c1-13-11-27-23(32-13)16-7-15(8-19(9-16)31-18-3-5-30-6-4-18)22(29)28-14(2)21-20(25)10-17(24)12-26-21/h7-12,14,18H,3-6H2,1-2H3,(H,28,29) UXQVDYSQMZTJPS-UHFFFAOYSA-N 319914 N-[1-(5- Chloro-3- fluoropyridin- 2-yl)ethyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5- (tetrahydro- 2H-pyran-4- yloxy) benzamide::US10174016, Example 81::US10202369, Example 81::US10472354, Example 81 P2X purinoceptor 3 Homo sapiens 3.00 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319914 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319914&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397622 384223194 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842602 Cc1cnc(s1)-c1cc(OC2CCOCC2)cc(c1)C(=O)NCc1ccc(C)nn1 InChI=1S/C22H24N4O3S/c1-14-3-4-18(26-25-14)13-23-21(27)16-9-17(22-24-12-15(2)30-22)11-20(10-16)29-19-5-7-28-8-6-19/h3-4,9-12,19H,5-8,13H2,1-2H3,(H,23,27) LSYGQIAUTJTZDJ-UHFFFAOYSA-N 319915 N-[(6- Methylpyridazin- 3-yl)methyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5- (tetrahydro- 2H-pyran-4- yloxy) benzamide::US10174016, Example 82::US10202369, Example 82::US10472354, Example 82 P2X purinoceptor 3 Homo sapiens 28.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319915 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319915&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397341 384223195 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842604 Cc1cnc(s1)-c1cc(OC2CCOCC2)cc(c1)C(=O)NCc1cnc(C)cn1 InChI=1S/C22H24N4O3S/c1-14-10-24-18(12-23-14)13-25-21(27)16-7-17(22-26-11-15(2)30-22)9-20(8-16)29-19-3-5-28-6-4-19/h7-12,19H,3-6,13H2,1-2H3,(H,25,27) YXUSESJBYZNMQE-UHFFFAOYSA-N 319916 N-[(5- Methylpyrazin- 2-yl)methyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5- (tetrahydro- 2H-pyran-4- yloxy) benzamide::US10174016, Example 83::US10202369, Example 83::US10472354, Example 83 P2X purinoceptor 3 Homo sapiens 125 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319916 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319916&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397170 384223196 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842606 C[C@@H](NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(C)s1)c1cnc(C)cn1 InChI=1S/C23H26N4O3S/c1-14-11-25-21(13-24-14)16(3)27-22(28)17-8-18(23-26-12-15(2)31-23)10-20(9-17)30-19-4-6-29-7-5-19/h8-13,16,19H,4-7H2,1-3H3,(H,27,28)/t16-/m1/s1 USCQOVGUOPYDKF-MRXNPFEDSA-N 319917 N-[(1R)-1-(5- Methylpyrazin- 2-yl)ethyl]- 3-(5-methyl- 1,3-thiazol-2- yl)-5- (tetrahydro- 2H-pyran-4- yloxy) benzamide::US10174016, Example 84::US10202369, Example 84::US10472354, Example 84 P2X purinoceptor 3 Homo sapiens 26.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319917 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319917&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397618 384223197 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842608 C[C@@H](NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H23F3N4O3S/c1-13-10-27-21(34-13)16-7-15(8-19(9-16)33-18-3-5-32-6-4-18)20(31)30-14(2)17-11-28-22(29-12-17)23(24,25)26/h7-12,14,18H,3-6H2,1-2H3,(H,30,31)/t14-/m1/s1 WGQQHPGXKFPPTQ-CQSZACIVSA-N 319918 3-(5-Methyl- 1,3-thiazol-2- yl)-5- (tetrahydro- 2H-pyran-4- yloxy)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 85::US10202369, Example 85::US10472354, Example 85 P2X purinoceptor 3 Homo sapiens 10.00 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319918 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319918&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397801 384223198 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842610 COc1ccc(cn1)[C@@H](C)NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(C)s1 InChI=1S/C24H27N3O4S/c1-15-13-26-24(32-15)19-10-18(11-21(12-19)31-20-6-8-30-9-7-20)23(28)27-16(2)17-4-5-22(29-3)25-14-17/h4-5,10-14,16,20H,6-9H2,1-3H3,(H,27,28)/t16-/m1/s1 HOSIWEZQKWEZJW-MRXNPFEDSA-N 319919 N-[(1R)-1-(6- Methoxypyridin- 3-yl)ethyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5- (tetrahydro- 2H-pyran-4- yloxy) benzamide::US10174016, Example 86::US10202369, Example 86::US10472354, Example 86 P2X purinoceptor 3 Homo sapiens 12.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319919 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319919&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397310 384223199 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842612 C[C@@H](NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(C)s1)c1ccc(C)nn1 InChI=1S/C23H26N4O3S/c1-14-4-5-21(27-26-14)16(3)25-22(28)17-10-18(23-24-13-15(2)31-23)12-20(11-17)30-19-6-8-29-9-7-19/h4-5,10-13,16,19H,6-9H2,1-3H3,(H,25,28)/t16-/m1/s1 OIHQARAAGWIFBW-MRXNPFEDSA-N 319920 N-[(1R)-1-(6- Methylpyridazin- 3-yl)ethyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5- (tetrahydro- 2H-pyran-4- yloxy) benzamide::US10174016, Example 87::US10202369, Example 87::US10472354, Example 87 P2X purinoceptor 3 Homo sapiens 15.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319920 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319920&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397290 384223200 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842614 COc1ccc(CNC(=O)c2cc(OC3CCOCC3)cc(c2)-c2ncc(C)s2)nn1 InChI=1S/C22H24N4O4S/c1-14-12-24-22(31-14)16-9-15(10-19(11-16)30-18-5-7-29-8-6-18)21(27)23-13-17-3-4-20(28-2)26-25-17/h3-4,9-12,18H,5-8,13H2,1-2H3,(H,23,27) FUPOQWQPMIFATK-UHFFFAOYSA-N 319921 N-[(6- Methoxy- pyridazin-3- yl)methyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5- (tetrahydro- 2H-pyran-4- yloxy) benzamide::US10174016, Example 88::US10202369, Example 88::US10472354, Example 88 P2X purinoceptor 3 Homo sapiens 30.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319921 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319921&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397556 384223201 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842616 C[C@@H](NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F InChI=1S/C23H23F3N4O3S/c1-13-12-27-22(34-13)16-9-15(10-18(11-16)33-17-5-7-32-8-6-17)21(31)28-14(2)19-3-4-20(30-29-19)23(24,25)26/h3-4,9-12,14,17H,5-8H2,1-2H3,(H,28,31)/t14-/m1/s1 RJKHHNIHJKFMMR-CQSZACIVSA-N 319922 3-(5-Methyl- 1,3-thiazol-2- yl)-5- (tetrahydro- 2H-pyran-4- yloxy)-N- {(1R)-1-[6- (trifluoromethyl) pyridazin- 3-yl]ethyl} benzamide::US10174016, Example 89::US10202369, Example 89::US10472354, Example 89 P2X purinoceptor 3 Homo sapiens 11.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319922 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319922&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397595 384223202 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842618 CC[C@@H](NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H25F3N4O3S/c1-3-20(17-12-29-23(30-13-17)24(25,26)27)31-21(32)15-8-16(22-28-11-14(2)35-22)10-19(9-15)34-18-4-6-33-7-5-18/h8-13,18,20H,3-7H2,1-2H3,(H,31,32)/t20-/m1/s1 ULSBLOPPTNALIT-HXUWFJFHSA-N 319923 3-(5-Methyl- 1,3-thiazol-2- yl)-5- (tetrahydro- 2H-pyran-4- yloxy)-N-{(1R)- 1-[2- (trifluorometh- yl)pyrimidin-5- yl]propyl}benz- amide::US10174016, Example 90::US10202369, Example 90::US10472354, Example 90 P2X purinoceptor 3 Homo sapiens 111 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319923 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319923&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397769 384223203 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842620 C[C@@H](NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(C)s1)c1ccc(C)nc1 InChI=1S/C24H27N3O3S/c1-15-4-5-18(14-25-15)17(3)27-23(28)19-10-20(24-26-13-16(2)31-24)12-22(11-19)30-21-6-8-29-9-7-21/h4-5,10-14,17,21H,6-9H2,1-3H3,(H,27,28)/t17-/m1/s1 VKTBTGUHIBZLBJ-QGZVFWFLSA-N 319924 N-[(1R)-1-(6- Methylpyridin- 3-yl)ethyl]-3- (5-methyl-1,3- thiazol-2-yl)-5- (tetrahydro- 2H-pyran-4- yloxy)benzamide::US10174016, Example 91::US10202369, Example 91::US10472354, Example 91 P2X purinoceptor 3 Homo sapiens 19.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319924 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319924&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397502 384223204 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842622 C[C@@H](NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(C)s1)c1nnc(C)s1 InChI=1S/C21H24N4O3S2/c1-12-11-22-21(29-12)16-8-15(9-18(10-16)28-17-4-6-27-7-5-17)19(26)23-13(2)20-25-24-14(3)30-20/h8-11,13,17H,4-7H2,1-3H3,(H,23,26)/t13-/m1/s1 GHXRECQLMZGPIV-CYBMUJFWSA-N 319925 N-[(1R)-1-(5- Methyl-1,3,4- thiadiazol-2- yl)ethyl]-3-(5- methyl-1,3- thiazol-2-yl)-5- (tetrahydro- 2H-pyran-4- yloxy)benzamide::US10174016, Example 92::US10202369, Example 92::US10472354, Example 92 P2X purinoceptor 3 Homo sapiens 24.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319925 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319925&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397542 384223205 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842624 Cc1cnc(s1)-c1cc(OCC2CCOCC2)cc(c1)C(=O)NCc1ccc(C)nn1 InChI=1S/C23H26N4O3S/c1-15-3-4-20(27-26-15)13-24-22(28)18-9-19(23-25-12-16(2)31-23)11-21(10-18)30-14-17-5-7-29-8-6-17/h3-4,9-12,17H,5-8,13-14H2,1-2H3,(H,24,28) QOXIPNMWVVZPOQ-UHFFFAOYSA-N 319926 N-[(6- Methyl- pyridazin-3- yl)methyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5- (tetrahydro- 2H-pyran-4- ylmethoxy) benzamide::US10174016, Example 93::US10202369, Example 93::US10472354, Example 93 P2X purinoceptor 3 Homo sapiens 8.00 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319926 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319926&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397788 384223206 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842626 C[C@@H](NC(=O)c1cc(OCC2CCOCC2)cc(c1)-c1ncc(C)s1)c1cnc(C)cn1 InChI=1S/C24H28N4O3S/c1-15-11-26-22(13-25-15)17(3)28-23(29)19-8-20(24-27-12-16(2)32-24)10-21(9-19)31-14-18-4-6-30-7-5-18/h8-13,17-18H,4-7,14H2,1-3H3,(H,28,29)/t17-/m1/s1 HCAZTDIYUNBLAC-QGZVFWFLSA-N 319927 N-[(1R)-1-(5- Methylpyrazin- 2-yl)ethyl]- 3-(5-methyl- 1,3-thiazol-2- yl)-5- (tetrahydro- 2H-pyran-4- ylmethoxy) benzamide::US10174016, Example 94::US10202369, Example 94::US10472354, Example 94 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319927 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319927&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397604 384223207 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842628 CC(NC(=O)c1cc(OCC2CCOCC2)cc(c1)-c1ncc(C)s1)c1ncc(Cl)cc1F InChI=1S/C24H25ClFN3O3S/c1-14-11-28-24(33-14)18-7-17(8-20(9-18)32-13-16-3-5-31-6-4-16)23(30)29-15(2)22-21(26)10-19(25)12-27-22/h7-12,15-16H,3-6,13H2,1-2H3,(H,29,30) WLBXKEKEIMKGRV-UHFFFAOYSA-N 319928 N-[1-(5- Chloro-3- fluoropyridin- 2-yl)ethyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5- (tetrahydro- 2H-pyran--4- ylmethoxy) benzamide::US10174016, Example 95::US10202369, Example 95::US10472354, Example 95 P2X purinoceptor 3 Homo sapiens 2.00 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319928 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319928&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397656 384223208 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842630 CC(NC(=O)c1cc(OCC2CCOCC2)cc(c1)-c1ncc(C)s1)c1ncc(F)cc1Cl InChI=1S/C24H25ClFN3O3S/c1-14-11-28-24(33-14)18-7-17(8-20(9-18)32-13-16-3-5-31-6-4-16)23(30)29-15(2)22-21(25)10-19(26)12-27-22/h7-12,15-16H,3-6,13H2,1-2H3,(H,29,30) YAVBCOZWMZVERS-UHFFFAOYSA-N 319929 N-[1-(3- Chloro-5- fluoropyridin- 2-yl)ethyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5- (tetrahydro- 2H-pyran-4- ylmethoxy) benzamide::US10174016, Example 96::US10202369, Example 96::US10472354, Example 96 P2X purinoceptor 3 Homo sapiens 18.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319929 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319929&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397482 384223209 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842632 Cc1cnc(s1)-c1cc(OCC2CCOCC2)cc(c1)C(=O)NCc1cnc(C)cn1 InChI=1S/C23H26N4O3S/c1-15-10-25-20(12-24-15)13-26-22(28)18-7-19(23-27-11-16(2)31-23)9-21(8-18)30-14-17-3-5-29-6-4-17/h7-12,17H,3-6,13-14H2,1-2H3,(H,26,28) VSGRXICPAXTBHX-UHFFFAOYSA-N 319930 N-[(5- Methylpyrazin- 2- yl)methyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5- (tetrahydro- 2H-pyran-4- ylmethoxy) benzamide::US10174016, Example 97::US10202369, Example 97::US10472354, Example 97 P2X purinoceptor 3 Homo sapiens 15.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319930 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319930&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397814 384223210 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842634 C[C@@H](NC(=O)c1cc(OCC2CCOCC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H25F3N4O3S/c1-14-10-28-22(35-14)18-7-17(8-20(9-18)34-13-16-3-5-33-6-4-16)21(32)31-15(2)19-11-29-23(30-12-19)24(25,26)27/h7-12,15-16H,3-6,13H2,1-2H3,(H,31,32)/t15-/m1/s1 MBJQALPRFLKOPN-OAHLLOKOSA-N 319931 3-(5-Methyl- 1,3-thiazol-2- yl)-5- (tetrahydro- 2H-pyran-4- ylmethoxy)- N-[(1R)-1-[2- (trifluorometh- yl)pyrimidin- 5- yl]ethyl] benzamide::US10174016, Example 98::US10202369, Example 98::US10472354, Example 98 P2X purinoceptor 3 Homo sapiens 1.000 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319931 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319931&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397231 384223211 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842636 C[C@@H](NC(=O)c1cc(OCC2CCOCC2)cc(c1)-c1ncc(C)s1)c1ccc(C)nn1 InChI=1S/C24H28N4O3S/c1-15-4-5-22(28-27-15)17(3)26-23(29)19-10-20(24-25-13-16(2)32-24)12-21(11-19)31-14-18-6-8-30-9-7-18/h4-5,10-13,17-18H,6-9,14H2,1-3H3,(H,26,29)/t17-/m1/s1 FNFCPAXHCILJLE-QGZVFWFLSA-N 319932 N-[(1R)-1-(6- Methyl- pyridazin-3- yl)ethyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5- (tetrahydro- 2H-pyran-4- ylmethoxy) benzamide::US10174016, Example 99::US10202369, Example 99::US10472354, Example 99 P2X purinoceptor 3 Homo sapiens 2.00 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319932 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319932&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397399 384223212 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842638 C[C@@H](NC(=O)c1cc(Oc2ccnc(C)c2)cc(c1)-c1ncc(C)s1)c1ccc(C)nn1 InChI=1S/C24H23N5O2S/c1-14-5-6-22(29-28-14)17(4)27-23(30)18-10-19(24-26-13-16(3)32-24)12-21(11-18)31-20-7-8-25-15(2)9-20/h5-13,17H,1-4H3,(H,27,30)/t17-/m1/s1 AOJXRFXYSRJHEO-QGZVFWFLSA-N 319933 N-[(1R)-1-(6- Methyl- pyridazin-3- yl)ethyl]-3- [(2- methylpyridin- 4-yl)oxy]-5- (5-methyl- 1,3-thiazol-2- yl)benzamide::US10174016, Example 100::US10202369, Example 100::US10472354, Example 100 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319933 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319933&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397202 384223213 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842640 Cc1cnc(s1)-c1cc(Oc2ccnc(C)c2)cc(c1)C(=O)NCc1ccc(C)nn1 InChI=1S/C23H21N5O2S/c1-14-4-5-19(28-27-14)13-25-22(29)17-9-18(23-26-12-16(3)31-23)11-21(10-17)30-20-6-7-24-15(2)8-20/h4-12H,13H2,1-3H3,(H,25,29) XCSQCNBYINKWNK-UHFFFAOYSA-N 319934 N-[(6- Methyl- pyridazin-3- yl)methyl]-3- [(2- methylpyridin- 4-yl)oxy]-5- (5-methyl- 1,3-thiazol-2- yl)benzamide::US10174016, Example 101::US10202369, Example 101::US10472354, Example 101 P2X purinoceptor 3 Homo sapiens 15.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319934 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319934&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397744 384223214 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842642 C[C@@H](NC(=O)c1cc(Oc2ccnc(C)c2)cc(c1)-c1ncc(C)s1)c1cnc(C)cn1 InChI=1S/C24H23N5O2S/c1-14-7-20(5-6-25-14)31-21-9-18(8-19(10-21)24-28-12-16(3)32-24)23(30)29-17(4)22-13-26-15(2)11-27-22/h5-13,17H,1-4H3,(H,29,30)/t17-/m1/s1 QEKNBUCJINMCOL-QGZVFWFLSA-N 319935 N-[(1R)-1-(5- Methylpyrazin- 2-yl)ethyl]- 3-[(2- methylpyridin- 4-yl)oxy]-5- (5-methyl- 1,3-thiazol-2- yl)benzamide::US10174016, Example 102::US10202369, Example 102::US10472354, Example 102 P2X purinoceptor 3 Homo sapiens 10.00 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319935 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319935&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397697 384223215 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842644 C[C@@H](NC(=O)c1cc(Oc2ccnc(C)c2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H20F3N5O2S/c1-13-6-19(4-5-28-13)34-20-8-16(7-17(9-20)22-29-10-14(2)35-22)21(33)32-15(3)18-11-30-23(31-12-18)24(25,26)27/h4-12,15H,1-3H3,(H,32,33)/t15-/m1/s1 JXFGKHKXOUTTKZ-OAHLLOKOSA-N 319936 3-[(2- Methylpyridin- 4-yl)oxy]-5- (5-methyl- 1,3-thiazol-2- yl)-N-{(1R)-1- [2- (trifluorometh- yl)pyrimidin- 5- yl]ethyl} benzamide::US10174016, Example 103::US10202369, Example 103::US10472354, Example 103 P2X purinoceptor 3 Homo sapiens 2.00 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319936 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319936&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397214 384223216 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842646 Cc1cnc(s1)-c1cc(Oc2ccnc(C)c2)cc(c1)C(=O)NCc1cnc(C)cn1 InChI=1S/C23H21N5O2S/c1-14-6-20(4-5-24-14)30-21-8-17(7-18(9-21)23-28-11-16(3)31-23)22(29)27-13-19-12-25-15(2)10-26-19/h4-12H,13H2,1-3H3,(H,27,29) FHRXECCRJLFVTP-UHFFFAOYSA-N 319937 N-[(5- Methylpyrazin- 2- yl)methyl]-3- [(2- methylpyridin- 4-yl)oxy]-5- (5-methyl- 1,3-thiazol-2- yl)benzamide::US10174016, Example 104::US10202369, Example 104::US10472354, Example 104 P2X purinoceptor 3 Homo sapiens 51.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319937 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319937&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397645 384223217 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842648 C[C@@H](NC(=O)c1cc(Oc2ccnc(C)c2)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F InChI=1S/C24H20F3N5O2S/c1-13-8-18(6-7-28-13)34-19-10-16(9-17(11-19)23-29-12-14(2)35-23)22(33)30-15(3)20-4-5-21(32-31-20)24(25,26)27/h4-12,15H,1-3H3,(H,30,33)/t15-/m1/s1 DZQXNDYGTRQHHO-OAHLLOKOSA-N 319938 3-[(2- Methylpyridin- 4-yl)oxy]-5- (5-methyl- 1,3-thiazol-2- yl)-N-{(1R)-1- [6- (trifluorometh- yl)pyridazin- 3- yl]ethyl} benzamide::US10174016, Example 105::US10202369, Example 105::US10472354, Example 105 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319938 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319938&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397847 384223218 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842650 C[C@@H](NC(=O)c1cc(Oc2ccnc(C)c2)cc(c1)-c1ncc(C)s1)c1cnc(C)nc1 InChI=1S/C24H23N5O2S/c1-14-7-21(5-6-25-14)31-22-9-18(8-19(10-22)24-28-11-15(2)32-24)23(30)29-16(3)20-12-26-17(4)27-13-20/h5-13,16H,1-4H3,(H,29,30)/t16-/m1/s1 AVOXIOANORGYFZ-MRXNPFEDSA-N 319939 3-[(2-methylpyridin-4-yl)oxy]-N-[(1R)-1-(2-methylpyrimidin-5-yl)ethyl]-5-(5-methyl-1,3-thiazol-2-yl)benzamide::US10174016, Example 106::US10202369, Example 106::US10472354, Example 106 P2X purinoceptor 3 Homo sapiens 16.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319939 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319939&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397227 384223219 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842652 C[C@@H](NC(=O)c1cc(Oc2ccnc(C)c2)cc(c1)-c1ncc(C)s1)c1ccc(C)nc1 InChI=1S/C25H24N4O2S/c1-15-5-6-19(14-27-15)18(4)29-24(30)20-10-21(25-28-13-17(3)32-25)12-23(11-20)31-22-7-8-26-16(2)9-22/h5-14,18H,1-4H3,(H,29,30)/t18-/m1/s1 PNIOXTPFLIQKJT-GOSISDBHSA-N 319940 N-[(1R)-1-(6- Methylpyridin- 3-yl)ethyl]- 3-[(2- methylpyridin- 4-yl)oxy]-5- (5-methyl- 1,3-thiazol-2- yl)benzamide::US10174016, Example 107::US10202369, Example 107::US10472354, Example 107 P2X purinoceptor 3 Homo sapiens 9.00 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319940 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319940&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397329 384223220 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842654 C[C@@H](NC(=O)c1cc(Oc2ccc(C)nc2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H20F3N5O2S/c1-13-4-5-19(12-28-13)34-20-7-16(6-17(8-20)22-29-9-14(2)35-22)21(33)32-15(3)18-10-30-23(31-11-18)24(25,26)27/h4-12,15H,1-3H3,(H,32,33)/t15-/m1/s1 ASXORIIIQIGPLA-OAHLLOKOSA-N 319941 3-[(6-Methylpyridin-3-yl)oxy]-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 108::US10202369, Example 108::US10472354, Example 108 P2X purinoceptor 3 Homo sapiens 11.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319941 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319941&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397249 384223221 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842656 C[C@@H](NC(=O)c1cc(Oc2nnc(C)s2)cc(c1)-c1ncc(C)s1)c1cnc(C)cn1 InChI=1S/C21H20N6O2S2/c1-11-8-23-18(10-22-11)13(3)25-19(28)15-5-16(20-24-9-12(2)30-20)7-17(6-15)29-21-27-26-14(4)31-21/h5-10,13H,1-4H3,(H,25,28)/t13-/m1/s1 SHPJQOXSFBKQMY-CYBMUJFWSA-N 319942 N-[(1R)-1-(5- Methylpyrazin- 2-yl)ethyl]-3- [(5-methyl- 1,3,4- thiadiazol-2- yl)oxy]-5-(5- methyl-1,3- thiazol-2- yl)benzamide::US10174016, Example 109::US10202369, Example 109::US10472354, Example 109 P2X purinoceptor 3 Homo sapiens 235 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319942 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319942&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397425 384223222 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842658 C[C@@H](NC(=O)c1cc(Oc2nnc(C)s2)cc(c1)-c1ncc(C)s1)c1ccc(C)nn1 InChI=1S/C21H20N6O2S2/c1-11-5-6-18(26-24-11)13(3)23-19(28)15-7-16(20-22-10-12(2)30-20)9-17(8-15)29-21-27-25-14(4)31-21/h5-10,13H,1-4H3,(H,23,28)/t13-/m1/s1 YBUIRLYLJALMRA-CYBMUJFWSA-N 319943 N-[(1R)-1-(6- Methylpyridazin- 3-yl)ethyl]- 3-[(5-methyl- 1,3,4- thiadiazol-2- yl)oxy]-5-(5- methyl-1,3- thiazol-2- yl)benzamide::US10174016, Example 110::US10202369, Example 110::US10472354, Example 110 P2X purinoceptor 3 Homo sapiens 114 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319943 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319943&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397265 384223223 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842660 C[C@@H](NC(=O)c1cc(Oc2nnc(C)s2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C21H17F3N6O2S2/c1-10-7-25-18(33-10)14-4-13(5-16(6-14)32-20-30-29-12(3)34-20)17(31)28-11(2)15-8-26-19(27-9-15)21(22,23)24/h4-9,11H,1-3H3,(H,28,31)/t11-/m1/s1 FIVDAXBJTLXBHI-LLVKDONJSA-N 319944 3-[(5-Methyl- 1,3,4- thiadiazol-2- yl)oxy]-5-(5- methyl-1,3- thiazol-2-yl)- N-[(1R)-1-[2- (trifluorometh- yl)pyrimidin-5- yl]ethyl] benzamide::US10174016, Example 111::US10202369, Example 111::US10472354, Example 111 P2X purinoceptor 3 Homo sapiens 16.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319944 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319944&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397223 384223224 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842662 C[C@@H](NC(=O)c1cc(Oc2nccs2)cc(c1)-c1ncc(C)s1)c1cnc(C)cn1 InChI=1S/C21H19N5O2S2/c1-12-9-24-18(11-23-12)14(3)26-19(27)15-6-16(20-25-10-13(2)30-20)8-17(7-15)28-21-22-4-5-29-21/h4-11,14H,1-3H3,(H,26,27)/t14-/m1/s1 QJIZPYNDSFDLFQ-CQSZACIVSA-N 319945 N-[(1R)-1-(5- Methylpyrazin- 2-yl)ethyl]-3- (5-methyl-1,3- thiazol-2-yl)-5- (1,3-thiazol-2- yloxy)benzamide::US10174016, Example 112::US10472354, Example 112 P2X purinoceptor 3 Homo sapiens 61.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319945 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319945&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397232 384223225 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842664 C[C@@H](NC(=O)c1cc(Oc2nccs2)cc(c1)-c1ncc(C)s1)c1ccc(C)nn1 InChI=1S/C21H19N5O2S2/c1-12-4-5-18(26-25-12)14(3)24-19(27)15-8-16(20-23-11-13(2)30-20)10-17(9-15)28-21-22-6-7-29-21/h4-11,14H,1-3H3,(H,24,27)/t14-/m1/s1 KTZHJRKMBNLACT-CQSZACIVSA-N 319946 N-[(1R)-1-(6- Methylpyridazin- 3-yl)ethyl]- 3-(5-methyl- 1,3-thiazol-2- yl)-5-(1,3- thiazol-2- yloxy)benzamide::US10174016, Example 113::US10202369, Example 113::US10472354, Example 113 P2X purinoceptor 3 Homo sapiens 43.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319946 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319946&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397679 384223226 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842666 C[C@@H](NC(=O)c1cc(Oc2nccs2)cc(c1)-c1ncc(C)s1)c1ccc(C)nc1 InChI=1S/C22H20N4O2S2/c1-13-4-5-16(12-24-13)15(3)26-20(27)17-8-18(21-25-11-14(2)30-21)10-19(9-17)28-22-23-6-7-29-22/h4-12,15H,1-3H3,(H,26,27)/t15-/m1/s1 WJNIKDPPMLYZOS-OAHLLOKOSA-N 319947 N-[(1R)-1-(6- Methylpyridin- 3-yl)ethyl]-3- (5-methyl-1,3- thiazol-2-yl)-5- (1,3-thiazol-2- yloxy)benzamide::US10174016, Example 114::US10202369, Example 114::US10472354, Example 114 P2X purinoceptor 3 Homo sapiens 38.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319947 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319947&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397612 384223227 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842668 COC(C)(C)COc1cc(cc(c1)-c1ncc(Cl)s1)C(=O)N[C@H](C)c1ccc(Cl)cn1 InChI=1S/C22H23Cl2N3O3S/c1-13(18-6-5-16(23)10-25-18)27-20(28)14-7-15(21-26-11-19(24)31-21)9-17(8-14)30-12-22(2,3)29-4/h5-11,13H,12H2,1-4H3,(H,27,28)/t13-/m1/s1 MHZRDUGBKYAKKB-CYBMUJFWSA-N 319948 N-[(1R)-1-(5-Chloropyridin-2-yl)ethyl]-3-(5-chloro-1,3-thiazol-2-yl)-5-(2-methoxy-2-methylpropoxy)benzamide::US10174016, Example 115::US10202369, Example 115::US10472354, Example 115 P2X purinoceptor 3 Homo sapiens 15.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319948 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319948&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397201 384223228 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842670 COC(C)(C)COc1cc(cc(c1)-c1ncc(Cl)s1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C22H22ClF3N4O3S/c1-12(15-8-28-20(29-9-15)22(24,25)26)30-18(31)13-5-14(19-27-10-17(23)34-19)7-16(6-13)33-11-21(2,3)32-4/h5-10,12H,11H2,1-4H3,(H,30,31)/t12-/m1/s1 QSHVLLWXZBADRN-GFCCVEGCSA-N 319949 3-(5-Chloro-1,3-thiazol-2-yl)-5-(2-methoxy-2-methylpropoxy)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 116::US10202369, Example 116::US10472354, Example 116 P2X purinoceptor 3 Homo sapiens 210 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319949 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319949&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397235 384223229 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842672 COC(C)(C)COc1cc(cc(c1)-c1ncc(Cl)s1)C(=O)N[C@H](C)c1cnc(C)cn1 InChI=1S/C22H25ClN4O3S/c1-13-9-25-18(10-24-13)14(2)27-20(28)15-6-16(21-26-11-19(23)31-21)8-17(7-15)30-12-22(3,4)29-5/h6-11,14H,12H2,1-5H3,(H,27,28)/t14-/m1/s1 IVUVTQZOIPAQFU-CQSZACIVSA-N 319950 3-(5-Chloro-1,3-thiazol-2-yl)-5-(2-methoxy-2-methylpropoxy)-N-[(1R)-1-(5-methylpyrazin-2-yl)ethyl]benzamide::US10174016, Example 117::US10202369, Example 117::US10472354, Example 117 P2X purinoceptor 3 Homo sapiens 36.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319950 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319950&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397711 384223230 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842674 Cc1ccc(CNC(=O)c2cc(OCC3CCOCC3)cc(c2)-c2ncc(s2)C(F)(F)F)nn1 InChI=1S/C23H23F3N4O3S/c1-14-2-3-18(30-29-14)11-27-21(31)16-8-17(22-28-12-20(34-22)23(24,25)26)10-19(9-16)33-13-15-4-6-32-7-5-15/h2-3,8-10,12,15H,4-7,11,13H2,1H3,(H,27,31) JVFRARFSFIRWBD-UHFFFAOYSA-N 319951 N-[(6-Methylpyridazin-3-yl)methyl]-3-(tetrahydro-2H-pyran-4-ylmethoxy)-5-[5-(trifluoromethyl)-1,3-thiazol-2-yl]benzamide::US10174016, Example 118::US10202369, Example 118::US10472354, Example 118 P2X purinoceptor 3 Homo sapiens 198 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319951 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319951&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397366 384223231 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842676 Cc1ccc(CNC(=O)c2cc(OCC3CCOCC3)cc(c2)-c2ncc(s2)C2CCC2)nn1 InChI=1S/C26H30N4O3S/c1-17-5-6-22(30-29-17)14-27-25(31)20-11-21(26-28-15-24(34-26)19-3-2-4-19)13-23(12-20)33-16-18-7-9-32-10-8-18/h5-6,11-13,15,18-19H,2-4,7-10,14,16H2,1H3,(H,27,31) UIEYRDUAWDAEID-UHFFFAOYSA-N 319952 3-(5-Cyclobutyl-1,3-thiazol-2-yl)-N-[(6-methylpyridazin-3-yl)methyl]-5-(tetrahydro-2H-pyran-4-ylmethoxy)benzamide::US10174016, Example 119::US10202369, Example 119::US10472354, Example 119 P2X purinoceptor 3 Homo sapiens 24.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319952 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319952&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397447 384223232 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842678 C[C@@H](NC(=O)c1cc(OCC2CCOCC2)cc(c1)-c1ncc(s1)C1CCC1)c1cnc(nc1)C(F)(F)F InChI=1S/C27H29F3N4O3S/c1-16(21-12-32-26(33-13-21)27(28,29)30)34-24(35)19-9-20(25-31-14-23(38-25)18-3-2-4-18)11-22(10-19)37-15-17-5-7-36-8-6-17/h9-14,16-18H,2-8,15H2,1H3,(H,34,35)/t16-/m1/s1 XFOWUTGLWQUPCN-MRXNPFEDSA-N 319953 3-(5-Cyclobutyl-1,3-thiazol-2-yl)-5-(tetrahydro-2H-pyran-4-ylmethoxy)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 120::US10202369, Example 120::US10472354, Example 120 P2X purinoceptor 3 Homo sapiens 14.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319953 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319953&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397437 384223233 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842680 C[C@@H](NC(=O)c1cc(OC[C@H]2CCOC2)cc(c1)-c1ncc(s1)C1CCC1)c1cnc(C)cn1 InChI=1S/C26H30N4O3S/c1-16-11-28-23(12-27-16)17(2)30-25(31)20-8-21(26-29-13-24(34-26)19-4-3-5-19)10-22(9-20)33-15-18-6-7-32-14-18/h8-13,17-19H,3-7,14-15H2,1-2H3,(H,30,31)/t17-,18+/m1/s1 ZBRXLMDGZXDHGV-MSOLQXFVSA-N 319954 3-(5-Cyclobutyl-1,3-thiazol-2-yl)-N-[(1R)-1-(5-methylpyrazin-2-yl)ethyl]-5-[(3S)-tetrahydrofuran-3-ylmethoxy]benzamide::US10174016, Example 121::US10202369, Example 121::US10472354, Example 271 P2X purinoceptor 3 Homo sapiens 79.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319954 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319954&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397486 384223234 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842682 Cc1ccc(CNC(=O)c2cc(OC[C@H]3CCOC3)cc(c2)-c2ncc(s2)C2CCC2)nn1 InChI=1S/C25H28N4O3S/c1-16-5-6-21(29-28-16)12-26-24(30)19-9-20(25-27-13-23(33-25)18-3-2-4-18)11-22(10-19)32-15-17-7-8-31-14-17/h5-6,9-11,13,17-18H,2-4,7-8,12,14-15H2,1H3,(H,26,30)/t17-/m0/s1 DCRIJNFHBDAZLX-KRWDZBQOSA-N 319955 3-(5-Cyclobutyl-1,3-thiazol-2-yl)-N-[(6-methylpyridazin-3-yl)methyl]-5-[(3S)-tetrahydrofuran-3-ylmethoxy]benzamide::US10174016, Example 122::US10202369, Example 122::US10472354, Example 122 P2X purinoceptor 3 Homo sapiens 106 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319955 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319955&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397270 384223235 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842684 C[C@@H](NC(=O)c1cc(OC[C@H]2CCOC2)cc(c1)-c1ncc(s1)C1CCC1)c1cnc(nc1)C(F)(F)F InChI=1S/C26H27F3N4O3S/c1-15(20-10-31-25(32-11-20)26(27,28)29)33-23(34)18-7-19(24-30-12-22(37-24)17-3-2-4-17)9-21(8-18)36-14-16-5-6-35-13-16/h7-12,15-17H,2-6,13-14H2,1H3,(H,33,34)/t15-,16+/m1/s1 JWRPHAGJMIAQMD-CVEARBPZSA-N 319956 3-(5-Cyclobutyl-1,3-thiazol-2-yl)-5-[(3S)-tetrahydrofuran-3-ylmethoxy]-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 123::US10202369, Example 123::US10472354, Example 272 P2X purinoceptor 3 Homo sapiens 46.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319956 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319956&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397161 384223236 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842686 C[C@@H](NC(=O)c1cc(OCC2CCOCC2)cc(c1)-c1ncc(s1)C1CCC1)c1cnc(C)nc1 InChI=1S/C27H32N4O3S/c1-17(23-13-28-18(2)29-14-23)31-26(32)21-10-22(27-30-15-25(35-27)20-4-3-5-20)12-24(11-21)34-16-19-6-8-33-9-7-19/h10-15,17,19-20H,3-9,16H2,1-2H3,(H,31,32)/t17-/m1/s1 WEHPOEFAIDTUPC-QGZVFWFLSA-N 319957 3-(5-Cyclobutyl-1,3-thiazol-2-yl)-N-[(1R)-1-(2-methylpyrimidin-5-yl)ethyl]-5-(tetrahydro-2H-pyran-4-ylmethoxy)benzamide::US10174016, Example 124::US10202369, Example 124::US10472354, Example 124 P2X purinoceptor 3 Homo sapiens 27.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319957 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319957&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397614 384223237 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842688 CCc1cnc(s1)-c1cc(OCC2CCOCC2)cc(c1)C(=O)N[C@H](C)c1cnc(C)nc1 InChI=1S/C25H30N4O3S/c1-4-23-14-28-25(33-23)20-9-19(10-22(11-20)32-15-18-5-7-31-8-6-18)24(30)29-16(2)21-12-26-17(3)27-13-21/h9-14,16,18H,4-8,15H2,1-3H3,(H,29,30)/t16-/m1/s1 DTZIYRRTWOGOEN-MRXNPFEDSA-N 319958 3-(5-Ethyl-1,3-thiazol-2-yl)-N-[(1R)-1-(2-methylpyrimidin-5-yl)ethyl]-5-(tetrahydro-2H-pyran-4-ylmethoxy)benzamide::US10174016, Example 125::US10202369, Example 125::US10472354, Example 125 P2X purinoceptor 3 Homo sapiens 3.00 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319958 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319958&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397256 384223238 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842690 CC(C)c1cnc(s1)-c1cc(OCC2CCOCC2)cc(c1)C(=O)N[C@H](C)c1cnc(C)nc1 InChI=1S/C26H32N4O3S/c1-16(2)24-14-29-26(34-24)21-9-20(10-23(11-21)33-15-19-5-7-32-8-6-19)25(31)30-17(3)22-12-27-18(4)28-13-22/h9-14,16-17,19H,5-8,15H2,1-4H3,(H,30,31)/t17-/m1/s1 OFIYJECBOJUELW-QGZVFWFLSA-N 319959 N-[(1R)-1-(2-Methylpyrimidin-5-yl)ethyl]-3-[5-(propan-2-yl)-1,3-thiazol-2-yl]-5-(tetrahydro-2H-pyran-4-ylmethoxy)benzamide::US10174016, Example 126::US10202369, Example 126::US10472354, Example 126 P2X purinoceptor 3 Homo sapiens 34.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319959 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319959&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397136 384223239 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842692 C[C@@H](NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(s1)C1CCC1)c1ccc(C)nn1 InChI=1S/C26H30N4O3S/c1-16-6-7-23(30-29-16)17(2)28-25(31)19-12-20(26-27-15-24(34-26)18-4-3-5-18)14-22(13-19)33-21-8-10-32-11-9-21/h6-7,12-15,17-18,21H,3-5,8-11H2,1-2H3,(H,28,31)/t17-/m1/s1 WWWCBSCSEOPHLV-QGZVFWFLSA-N 319960 3-(5-Cyclobutyl-1,3-thiazol-2-yl)-N-[(1R)-1-(6-methylpyridazin-3-yl)ethyl]-5-(tetrahydro-2H-pyran-4-yloxy)benzamide::US10174016, Example 127::US10202369, Example 127::US10472354, Example 127 P2X purinoceptor 3 Homo sapiens 111 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319960 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319960&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397331 384223240 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842694 CCc1cnc(s1)-c1cc(OC2CCOCC2)cc(c1)C(=O)N[C@H](C)c1ccc(C)nn1 InChI=1S/C24H28N4O3S/c1-4-21-14-25-24(32-21)18-11-17(12-20(13-18)31-19-7-9-30-10-8-19)23(29)26-16(3)22-6-5-15(2)27-28-22/h5-6,11-14,16,19H,4,7-10H2,1-3H3,(H,26,29)/t16-/m1/s1 ZSPSPZOSCRXZOC-MRXNPFEDSA-N 319961 3-(5-Ethyl-1,3-thiazol-2-yl)-N-[(1R)-1-(6-methylpyridazin-3-yl)ethyl]-5-(tetrahydro-2H-pyran-4-yloxy)benzamide::US10174016, Example 128::US10202369, Example 128::US10472354, Example 128 P2X purinoceptor 3 Homo sapiens 10.00 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319961 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319961&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397510 384223241 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842696 CCc1cnc(s1)-c1cc(OC2CCOCC2)cc(c1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C24H25F3N4O3S/c1-3-20-13-28-22(35-20)16-8-15(9-19(10-16)34-18-4-6-33-7-5-18)21(32)31-14(2)17-11-29-23(30-12-17)24(25,26)27/h8-14,18H,3-7H2,1-2H3,(H,31,32)/t14-/m1/s1 HAECKPIYFMDTPM-CQSZACIVSA-N 319962 3-(5-Ethyl-1,3-thiazol-2-yl)-5-(tetrahydro-2H-pyran-4-yloxy)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 129::US10202369, Example 129::US10472354, Example 129 P2X purinoceptor 3 Homo sapiens 3.00 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319962 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319962&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397362 384223242 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842698 C[C@@H](NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1cnc(C)nc1 InChI=1S/C22H24N4O3S/c1-13-9-25-22(30-13)17-6-16(7-20(8-17)29-19-4-5-28-12-19)21(27)26-14(2)18-10-23-15(3)24-11-18/h6-11,14,19H,4-5,12H2,1-3H3,(H,26,27)/t14-,19+/m1/s1 RHVHBKMOULQMJQ-KUHUBIRLSA-N 319963 N-[(1R)-1-(2-Methylpyrimidin-5-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(3S)-tetrahydrofuran-3-yloxy]benzamide::US10174016, Example 130::US10202369, Example 130::US10472354, Example 130 P2X purinoceptor 3 Homo sapiens 74.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319963 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319963&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397599 384223243 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842700 C[C@@H](NC(=O)c1cc(Oc2ccc(C)nc2)cc(c1)-c1ncc(C)s1)c1cnc(C)cn1 InChI=1S/C24H23N5O2S/c1-14-5-6-20(12-25-14)31-21-8-18(7-19(9-21)24-28-11-16(3)32-24)23(30)29-17(4)22-13-26-15(2)10-27-22/h5-13,17H,1-4H3,(H,29,30)/t17-/m1/s1 PZARJLLATJAKMG-QGZVFWFLSA-N 319964 N-[(1R)-1-(5-methylpyrazin-2-yl)ethyl]-3-[(6-methylpyridin-3-yl)oxy]-5-(5-methyl-1,3-thiazol-2-yl)benzamide::US10174016, Example 131::US10202369, Example 131::US10472354, Example 131 P2X purinoceptor 3 Homo sapiens 134 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319964 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319964&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397434 384223244 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842702 CC(NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ncc(F)cc1Cl InChI=1S/C22H21ClFN3O3S/c1-12-9-26-22(31-12)15-5-14(6-18(7-15)30-17-3-4-29-11-17)21(28)27-13(2)20-19(23)8-16(24)10-25-20/h5-10,13,17H,3-4,11H2,1-2H3,(H,27,28)/t13?,17-/m0/s1 YETTUNLUNMEXML-RUINGEJQSA-N 319965 N-[1-(3-Chloro-5-fluoropyridin-2-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(3S)-tetrahydrofuran-3-yloxy]benzamide::US10174016, Example 132::US10202369, Example 132::US10472354, Example 132 P2X purinoceptor 3 Homo sapiens 75.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319965 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319965&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397504 384223245 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842704 Cc1cnc(s1)-c1cc(O[C@H]2CCOC2)cc(c1)C(=O)NCc1ccc(C)nn1 InChI=1S/C21H22N4O3S/c1-13-3-4-17(25-24-13)11-22-20(26)15-7-16(21-23-10-14(2)29-21)9-19(8-15)28-18-5-6-27-12-18/h3-4,7-10,18H,5-6,11-12H2,1-2H3,(H,22,26)/t18-/m0/s1 VKRRMZCTKMLCQJ-SFHVURJKSA-N 319966 N-[(6-Methylpyridazin-3-yl)methyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(3S)-tetrahydrofuran-3-yloxy]benzamide::US10174016, Example 133::US10202369, Example 133::US10472354, Example 133 P2X purinoceptor 3 Homo sapiens 177 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319966 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319966&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397536 384223246 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842706 CC(NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ncc(Cl)cc1F InChI=1S/C22H21ClFN3O3S/c1-12-9-26-22(31-12)15-5-14(6-18(7-15)30-17-3-4-29-11-17)21(28)27-13(2)20-19(24)8-16(23)10-25-20/h5-10,13,17H,3-4,11H2,1-2H3,(H,27,28)/t13?,17-/m0/s1 DLODQDUFIVUCLQ-RUINGEJQSA-N 319967 N-[1-(5-Chloro-3-fluoropyridin-2-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(3S)-tetrahydrofuran-3-yloxy]benzamide::US10174016, Example 134::US10202369, Example 134::US10472354, Example 134 P2X purinoceptor 3 Homo sapiens 15.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319967 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319967&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397151 384223247 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842708 C[C@@H](NC(=O)c1cc(OC[C@H]2CCOC2)cc(c1)-c1ncc(s1)C1CCC1)c1ccc(C)nn1 InChI=1S/C26H30N4O3S/c1-16-6-7-23(30-29-16)17(2)28-25(31)20-10-21(26-27-13-24(34-26)19-4-3-5-19)12-22(11-20)33-15-18-8-9-32-14-18/h6-7,10-13,17-19H,3-5,8-9,14-15H2,1-2H3,(H,28,31)/t17-,18+/m1/s1 KRMAXJMLJAVOGJ-MSOLQXFVSA-N 319968 3-(5-Cyclobutyl-1,3-thiazol-2-yl)-N-[(1R)-1-(6-methylpyridazin-3-yl)ethyl]-5-[(3S)-tetrahydrofuran-3-ylmethoxy]benzamide::US10174016, Example 135::US10202369, Example 135::US10472354, Example 270 P2X purinoceptor 3 Homo sapiens 35.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319968 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319968&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397422 384223248 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842710 COCCOc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1cnc(C)nc1 InChI=1S/C21H24N4O3S/c1-13-10-24-21(29-13)17-7-16(8-19(9-17)28-6-5-27-4)20(26)25-14(2)18-11-22-15(3)23-12-18/h7-12,14H,5-6H2,1-4H3,(H,25,26)/t14-/m1/s1 NMXUVEDIBFBQMK-CQSZACIVSA-N 319969 3-(2-Methoxyethoxy)-N-[(1R)-1-(2-methylpyrimidin-5-yl)ethyl]-5-(5-methyl-1,3-thiazol-2-yl)benzamide::US10174016, Example 136::US10202369, Example 136::US10472354, Example 136 P2X purinoceptor 3 Homo sapiens 196 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319969 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319969&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397574 384223249 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842712 C[C@@H](NC(=O)c1cc(OC2CCN(CC2)C(=O)OC(C)(C)C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C28H32F3N5O4S/c1-16-13-32-24(41-16)19-10-18(23(37)35-17(2)20-14-33-25(34-15-20)28(29,30)31)11-22(12-19)39-21-6-8-36(9-7-21)26(38)40-27(3,4)5/h10-15,17,21H,6-9H2,1-5H3,(H,35,37)/t17-/m1/s1 FLJTWWMLFZUWSL-QGZVFWFLSA-N 319970 US10174016, Example 137::US10472354, Example 137::tert-Butyl 4-[3-(5-methyl-1,3-thiazol-2-yl)-5-({(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}carbamoyl)phenoxy]piperidine-1-carboxylate P2X purinoceptor 3 Homo sapiens 26.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319970 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319970&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397466 384223250 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842714 C[C@@H](NC(=O)c1cc(OC2CCNCC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H24F3N5O2S/c1-13-10-28-21(34-13)16-7-15(8-19(9-16)33-18-3-5-27-6-4-18)20(32)31-14(2)17-11-29-22(30-12-17)23(24,25)26/h7-12,14,18,27H,3-6H2,1-2H3,(H,31,32)/t14-/m1/s1 AUEVADIQWKJNQT-CQSZACIVSA-N 319971 3-(5-Methyl-1,3-thiazol-2-yl)-5-(piperidin-4-yloxy)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 138::US10202369, Example 138::US10472354, Example 138 P2X purinoceptor 3 Homo sapiens 11.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319971 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319971&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397389 384223251 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842716 C[C@@H](NC(=O)c1cc(OC2CCN(C)CC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H26F3N5O2S/c1-14-11-28-22(35-14)17-8-16(9-20(10-17)34-19-4-6-32(3)7-5-19)21(33)31-15(2)18-12-29-23(30-13-18)24(25,26)27/h8-13,15,19H,4-7H2,1-3H3,(H,31,33)/t15-/m1/s1 BKNIRTNEYAOJDL-OAHLLOKOSA-N 319972 3-[(1-Methylpiperidin-4-yl)oxy]-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 139::US10202369, Example 139::US10472354, Example 215 P2X purinoceptor 3 Homo sapiens 8.00 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319972 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319972&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397521 384223252 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842718 CC(C)N1CCC(CC1)Oc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C26H30F3N5O2S/c1-15(2)34-7-5-21(6-8-34)36-22-10-18(9-19(11-22)24-30-12-16(3)37-24)23(35)33-17(4)20-13-31-25(32-14-20)26(27,28)29/h9-15,17,21H,5-8H2,1-4H3,(H,33,35)/t17-/m1/s1 JAJQPYKLEVBCIY-QGZVFWFLSA-N 319973 3-(5-Methyl-1,3-thiazol-2-yl)-5-{[1-(propan-2-yl)piperidin-4-yl]oxy}-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 140::US10202369, Example 140::US10472354, Example 140 P2X purinoceptor 3 Homo sapiens 33.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319973 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319973&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397336 384223253 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842720 C[C@@H](NC(=O)c1cc(O[C@@H]2CCN(C)C2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H24F3N5O2S/c1-13-9-27-21(34-13)16-6-15(7-19(8-16)33-18-4-5-31(3)12-18)20(32)30-14(2)17-10-28-22(29-11-17)23(24,25)26/h6-11,14,18H,4-5,12H2,1-3H3,(H,30,32)/t14-,18-/m1/s1 RNHSPVKPEXJLAD-RDTXWAMCSA-N 319974 3-{[(3R)-1-Methylpyrrolidin-3-yl]oxy}-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 141::US10202369, Example 141::US10472354, Example 141 P2X purinoceptor 3 Homo sapiens 43.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319974 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319974&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397272 384223254 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842722 C[C@@H](NC(=O)c1cc(O[C@H]2CCN(C)C2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H24F3N5O2S/c1-13-9-27-21(34-13)16-6-15(7-19(8-16)33-18-4-5-31(3)12-18)20(32)30-14(2)17-10-28-22(29-11-17)23(24,25)26/h6-11,14,18H,4-5,12H2,1-3H3,(H,30,32)/t14-,18+/m1/s1 RNHSPVKPEXJLAD-KDOFPFPSSA-N 319975 3-{[(3S)-1-Methylpyrrolidin-3-yl]oxy}-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 142::US10202369, Example 142::US10472354, Example 142 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319975 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319975&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397181 384223255 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842724 C[C@@H](NC(=O)c1cc(OC2CN(C)C2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C22H22F3N5O2S/c1-12-7-26-20(33-12)15-4-14(5-17(6-15)32-18-10-30(3)11-18)19(31)29-13(2)16-8-27-21(28-9-16)22(23,24)25/h4-9,13,18H,10-11H2,1-3H3,(H,29,31)/t13-/m1/s1 NFRXFSQBXDHWHW-CYBMUJFWSA-N 319976 3-[(1-Methylazetidin-3-yl)oxy]-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 143::US10202369, Example 143::US10472354, Example 143 P2X purinoceptor 3 Homo sapiens 84.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319976 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319976&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397519 384223256 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842726 C[C@H](NC(=O)c1cc(OCC#C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C21H17F3N4O2S/c1-4-5-30-17-7-14(6-15(8-17)19-25-9-12(2)31-19)18(29)28-13(3)16-10-26-20(27-11-16)21(22,23)24/h1,6-11,13H,5H2,2-3H3,(H,28,29)/t13-/m0/s1 BTRSFHCVZJPJKT-ZDUSSCGKSA-N 319977 3-(5-Methyl-1,3-thiazol-2-yl)-5-(prop-2-yn-1-yloxy)-N-{(1S)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 144::US10202369, Example 144::US10472354, Example 144 P2X purinoceptor 3 Homo sapiens 825 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319977 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319977&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397460 384223257 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842728 C[C@H](NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H23F3N4O3S/c1-13-10-27-21(34-13)16-7-15(8-19(9-16)33-18-3-5-32-6-4-18)20(31)30-14(2)17-11-28-22(29-12-17)23(24,25)26/h7-12,14,18H,3-6H2,1-2H3,(H,30,31)/t14-/m0/s1 WGQQHPGXKFPPTQ-AWEZNQCLSA-N 319978 3-(5-Methyl-1,3-thiazol-2-yl)-5-(tetrahydro-2H-pyran-4-yloxy)-N-{(1S)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 145::US10202369, Example 145::US10472354, Example 145 P2X purinoceptor 3 Homo sapiens 271 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319978 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319978&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397306 384223258 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842730 C[C@@H](NC(=O)c1cc(OC2CC3(C2)CN(C3)C(=O)OC(C)(C)C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C29H32F3N5O4S/c1-16-11-33-24(42-16)19-6-18(23(38)36-17(2)20-12-34-25(35-13-20)29(30,31)32)7-21(8-19)40-22-9-28(10-22)14-37(15-28)26(39)41-27(3,4)5/h6-8,11-13,17,22H,9-10,14-15H2,1-5H3,(H,36,38)/t17-/m1/s1 GOFUMWOIVIXXIJ-QGZVFWFLSA-N 319979 US10174016, Example 146::US10202369, Example 146::US10472354, Example 146::tert-butyl 6-[3-(5- methyl-1,3- thiazol-2-yl)-5- ({(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}carbamoyl) phenoxy]-2- azaspiro[3.3]heptane- 2-carboxylate P2X purinoceptor 3 Homo sapiens 45.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319979 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319979&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397340 384223259 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842732 C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1cnc(cn1)C(F)(F)F InChI=1S/C22H21F3N4O3S/c1-12-8-28-21(33-12)15-5-14(6-17(7-15)32-16-3-4-31-11-16)20(30)29-13(2)18-9-27-19(10-26-18)22(23,24)25/h5-10,13,16H,3-4,11H2,1-2H3,(H,29,30)/t13-,16-/m1/s1 DVMONFUPUPPMFW-CZUORRHYSA-N 319980 3-(5-methyl-1,3- thiazol-2-yl)-5- [(3R)- tetrahydrofuran-3- yloxy]-N-{(1R)-1- [5- (trifluoromethyl) pyrazin-2- yl]ethyl}benzamide::US10174016, Example 147::US10202369, Example 147::US10472354, Example 147 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319980 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319980&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397189 384223260 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842734 C[C@@H](NC(=O)c1cc(OC2COC2)cc(c1)-c1ncc(C)s1)c1ccc(nc1)C(F)(F)F InChI=1S/C22H20F3N3O3S/c1-12-8-27-21(32-12)16-5-15(6-17(7-16)31-18-10-30-11-18)20(29)28-13(2)14-3-4-19(26-9-14)22(23,24)25/h3-9,13,18H,10-11H2,1-2H3,(H,28,29)/t13-/m1/s1 NAXHTXVAPBZYNR-CYBMUJFWSA-N 319981 3-(5-methyl-1,3- thiazol-2-yl)-5- (oxetan-3-yloxy)- N-{(1R)-1-[6- (trifluoromethyl) pyridin-3- yl]ethyl}benzamide::US10174016, Example 148::US10202369, Example 148::US10472354, Example 148 P2X purinoceptor 3 Homo sapiens 33.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319981 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319981&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397138 384223261 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842736 C[C@@H](NC(=O)c1cc(OC23CCN(CC2)CC3)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C25H26F3N5O2S/c1-15-12-29-22(36-15)18-9-17(10-20(11-18)35-24-3-6-33(7-4-24)8-5-24)21(34)32-16(2)19-13-30-23(31-14-19)25(26,27)28/h9-14,16H,3-8H2,1-2H3,(H,32,34)/t16-/m1/s1 RAGSAJSSGMANHP-MRXNPFEDSA-N 319982 3-(1- azabicyclo[2.2.2] oct-4-yloxy)-5-(5- methyl-1,3- thiazol-3-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 149::US10202369, Example 149::US10472354, Example 149 P2X purinoceptor 3 Homo sapiens 21.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319982 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319982&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397715 384223262 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842738 C[C@@H](NC(=O)c1cc(OC2CCN(CC2)C(C)=O)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C25H26F3N5O3S/c1-14-11-29-23(37-14)18-8-17(9-21(10-18)36-20-4-6-33(7-5-20)16(3)34)22(35)32-15(2)19-12-30-24(31-13-19)25(26,27)28/h8-13,15,20H,4-7H2,1-3H3,(H,32,35)/t15-/m1/s1 ISMQQTCWBNBFKY-OAHLLOKOSA-N 319983 3-[(1- acetylpiperidin-4- yl)oxy]-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 150::US10202369, Example 150::US10472354, Example 150 P2X purinoceptor 3 Homo sapiens 12.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319983 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319983&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397215 384223263 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842740 C[C@@H](NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)F InChI=1S/C22H22F2N4O3S/c1-12-8-27-22(32-12)15-5-14(6-18(7-15)31-17-3-4-30-11-17)21(29)28-13(2)16-9-25-20(19(23)24)26-10-16/h5-10,13,17,19H,3-4,11H2,1-2H3,(H,28,29)/t13-,17+/m1/s1 AUVRCFBFFFYNAV-DYVFJYSZSA-N 319984 N-{(1R)-1-[2- (difluoromethyl) pyrimidin-5- yl]ethyl}-3-(5- methyl-1,3- thiazol-2-yl)-5- [(3S)- tetrahydrofuran-3- yloxy]benzamide::US10174016, Example 151::US10202369, Example 151::US10472354, Example 151 P2X purinoceptor 3 Homo sapiens 31.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319984 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319984&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397480 384223264 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842742 C[C@@H](NC(=O)c1cc(OC2COC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)F InChI=1S/C21H20F2N4O3S/c1-11-6-26-21(31-11)14-3-13(4-16(5-14)30-17-9-29-10-17)20(28)27-12(2)15-7-24-19(18(22)23)25-8-15/h3-8,12,17-18H,9-10H2,1-2H3,(H,27,28)/t12-/m1/s1 YTKWIWSPGJOVJL-GFCCVEGCSA-N 319985 N-{(1R)-1-[2- (difluoromethyl) pyrimidin-5- yl]ethyl}-3-(5- methyl-1,3- thiazol-2-yl)-5- (oxetan-3- yloxy)benzamide::US10174016, Example 152::US10202369, Example 152::US10472354, Example 152 P2X purinoceptor 3 Homo sapiens 45.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319985 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319985&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397528 384223265 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842744 C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)F InChI=1S/C22H22F2N4O3S/c1-12-8-27-22(32-12)15-5-14(6-18(7-15)31-17-3-4-30-11-17)21(29)28-13(2)16-9-25-20(19(23)24)26-10-16/h5-10,13,17,19H,3-4,11H2,1-2H3,(H,28,29)/t13-,17-/m1/s1 AUVRCFBFFFYNAV-CXAGYDPISA-N 319986 N-{(1R)-1-[2- (difluoromethyl) pyrimidin-5- yl]ethyl}-3-(5- methyl-1,3- thiazol-2-yl)-5- [(3R)- tetrahydrofuran-3- yloxy]benzamide::US10174016, Example 153::US10202369, Example 153::US10472354, Example 153 P2X purinoceptor 3 Homo sapiens 27.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319986 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319986&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397665 384223266 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842746 C[C@@H](NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)F InChI=1S/C23H24F2N4O3S/c1-13-10-28-23(33-13)16-7-15(8-19(9-16)32-18-3-5-31-6-4-18)22(30)29-14(2)17-11-26-21(20(24)25)27-12-17/h7-12,14,18,20H,3-6H2,1-2H3,(H,29,30)/t14-/m1/s1 RQWRZCMIWXGQJP-CQSZACIVSA-N 319987 N-{(1R)-1-[2- (difluoromethyl) pyrimidin-5- yl]ethyl}-3-(5- methyl-1,3- thiazol-2-yl)-5- (tetrahydro-2H- pyran-4- yloxy)benzamide::US10174016, Example 154::US10202369, Example 154::US10472354, Example 154 P2X purinoceptor 3 Homo sapiens 18.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319987 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319987&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397560 384223267 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842748 C[C@@H](NC(=O)c1cc(O[C@H]2CCCN(C)C2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H26F3N5O2S/c1-14-10-28-22(35-14)17-7-16(8-20(9-17)34-19-5-4-6-32(3)13-19)21(33)31-15(2)18-11-29-23(30-12-18)24(25,26)27/h7-12,15,19H,4-6,13H2,1-3H3,(H,31,33)/t15-,19+/m1/s1 DNVWWBHMIGZIMX-BEFAXECRSA-N 319988 3-{[(3S)-1- methylpiperidin-3- yl]oxy}-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 155::US10174016, Example 221::US10202369, Example 155::US10472354, Example 155 P2X purinoceptor 3 Homo sapiens 40.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319988 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319988&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397794 384223268 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842750 C[C@@H](NC(=O)c1cc(OC2(C)COC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C22H21F3N4O3S/c1-12-7-26-19(33-12)15-4-14(5-17(6-15)32-21(3)10-31-11-21)18(30)29-13(2)16-8-27-20(28-9-16)22(23,24)25/h4-9,13H,10-11H2,1-3H3,(H,29,30)/t13-/m1/s1 OYDLDEWAXBGGBJ-CYBMUJFWSA-N 319989 3-[(3- methyloxetan-3- yl)oxy]-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 156::US10202369, Example 156::US10472354, Example 156 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319989 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319989&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397627 384223269 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842752 C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ccc(nc1)C(F)(F)F InChI=1S/C23H22F3N3O3S/c1-13-10-28-22(33-13)17-7-16(8-19(9-17)32-18-5-6-31-12-18)21(30)29-14(2)15-3-4-20(27-11-15)23(24,25)26/h3-4,7-11,14,18H,5-6,12H2,1-2H3,(H,29,30)/t14-,18-/m1/s1 RHAXZNLWUJRHEA-RDTXWAMCSA-N 319990 3-(5-methyl-1,3- thiazol-2-yl)-5- [(3R)- tetrahydrofuran-3- yloxy]-N-{(1R)-1- [6- (trifluoromethyl) pyridin-3- yl]ethyl}benzamide::US10174016, Example 157::US10202369, Example 157::US10472354, Example 157 P2X purinoceptor 3 Homo sapiens 17.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319990 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319990&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397372 384223270 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842754 C[C@@H](NC(=O)c1cc(O[C@@H]2CCCN(C)C2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H26F3N5O2S/c1-14-10-28-22(35-14)17-7-16(8-20(9-17)34-19-5-4-6-32(3)13-19)21(33)31-15(2)18-11-29-23(30-12-18)24(25,26)27/h7-12,15,19H,4-6,13H2,1-3H3,(H,31,33)/t15-,19-/m1/s1 DNVWWBHMIGZIMX-DNVCBOLYSA-N 319991 3-{[(3R)-1- methylpiperidin-3- yl]oxy}-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 158::US10174016, Example 220::US10202369, Example 158::US10472354, Example 158 P2X purinoceptor 3 Homo sapiens 21.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319991 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319991&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397414 384223271 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842756 C[C@@H](NC(=O)c1cc(OCCn2cncn2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C22H20F3N7O2S/c1-13-8-27-20(35-13)16-5-15(6-18(7-16)34-4-3-32-12-26-11-30-32)19(33)31-14(2)17-9-28-21(29-10-17)22(23,24)25/h5-12,14H,3-4H2,1-2H3,(H,31,33)/t14-/m1/s1 HYNLHPVSAUUUKN-CQSZACIVSA-N 319992 3-(5-methyl-1,3- thiazol-2-yl)-5-[2- (1H-1,2,4-triazol- 1-yl)ethoxy]-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 159::US10202369, Example 159::US10472354, Example 159 P2X purinoceptor 3 Homo sapiens 28.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319992 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319992&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397126 384223272 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842758 C[C@@H](NC(=O)c1cc(OCCn2cncn2)cc(c1)-c1ncc(C)s1)c1ccc(nc1)C(F)(F)F InChI=1S/C23H21F3N6O2S/c1-14-10-29-22(35-14)18-7-17(8-19(9-18)34-6-5-32-13-27-12-30-32)21(33)31-15(2)16-3-4-20(28-11-16)23(24,25)26/h3-4,7-13,15H,5-6H2,1-2H3,(H,31,33)/t15-/m1/s1 ZEDPNXXTTLJFPM-OAHLLOKOSA-N 319993 3-(5-methyl-1,3- thiazol-2-yl)-5-[2- (1H-1,2,4-triazol- 1-yl)ethoxy]-N- {(1R)-1-[6- (trifluoromethyl) pyridin-3- yl]ethyl}benzamide::US10174016, Example 160::US10202369, Example 160::US10472354, Example 160 P2X purinoceptor 3 Homo sapiens 28.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319993 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319993&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397838 384223273 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842760 C[C@@H](NC(=O)c1cc(OC2COC2)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F InChI=1S/C21H19F3N4O3S/c1-11-8-25-20(32-11)14-5-13(6-15(7-14)31-16-9-30-10-16)19(29)26-12(2)17-3-4-18(28-27-17)21(22,23)24/h3-8,12,16H,9-10H2,1-2H3,(H,26,29)/t12-/m1/s1 GINDYDBHFAVPIL-GFCCVEGCSA-N 319994 3-(5-methyl-1,3- thiazol-2-yl)-5- (oxetan-3-yloxy)- N-{(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl}benzamide::US10174016, Example 161::US10202369, Example 161::US10472354, Example 161 P2X purinoceptor 3 Homo sapiens 32.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319994 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319994&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397757 384223274 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842762 CC(O)C(C)Oc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C22H23F3N4O3S/c1-11-8-26-20(33-11)16-5-15(6-18(7-16)32-14(4)13(3)30)19(31)29-12(2)17-9-27-21(28-10-17)22(23,24)25/h5-10,12-14,30H,1-4H3,(H,29,31)/t12-,13?,14?/m0/s1 FSGDRFBLPAILDE-HSBZDZAISA-N 319996 US10174016, Example 163::US10202369, Example 340::US10472354, Example 162 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319996 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319996&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134328174 384223276 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842764 CC(O)C(C)Oc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C22H23F3N4O3S/c1-11-8-26-20(33-11)16-5-15(6-18(7-16)32-14(4)13(3)30)19(31)29-12(2)17-9-27-21(28-10-17)22(23,24)25/h5-10,12-14,30H,1-4H3,(H,29,31)/t12-,13?,14?/m1/s1 FSGDRFBLPAILDE-IYXRBSQSSA-N 319995 3-{[3-hydroxybutan-2-yl]oxy}-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 162::US10174016, Example 338::US10202369, Example 339::US10472354, Example 338 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319995 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319995&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397269 384223275 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842766 C[C@@H](NC(=O)c1cc(OC2COC2)cc(c1)-c1ncc(C)s1)c1ccc(nc1)C(F)F InChI=1S/C22H21F2N3O3S/c1-12-8-26-22(31-12)16-5-15(6-17(7-16)30-18-10-29-11-18)21(28)27-13(2)14-3-4-19(20(23)24)25-9-14/h3-9,13,18,20H,10-11H2,1-2H3,(H,27,28)/t13-/m1/s1 VIFFUASYGYMCSF-CYBMUJFWSA-N 319997 N-{[(1R)-1-[6- (difluoromethyl) pyridin-3-yl]ethyl}-3- (5-methyl-1,3- thiazol-2-yl)-5- (oxetan-3- yloxy)benzamide::US10174016, Example 164::US10202369, Example 164::US10472354, Example 164 P2X purinoceptor 3 Homo sapiens 60.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319997 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319997&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397252 384223277 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842768 C[C@@H](NC(=O)c1cc(O[C@H]2C[C@@H](C2)N(C)C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H26F3N5O2S/c1-13-10-28-22(35-13)16-5-15(6-19(7-16)34-20-8-18(9-20)32(3)4)21(33)31-14(2)17-11-29-23(30-12-17)24(25,26)27/h5-7,10-12,14,18,20H,8-9H2,1-4H3,(H,31,33)/t14-,18-,20-/m1/s1 AGHYBRFMKRJHNY-LXGCGDOSSA-N 319998 3-{[trans-3- (dimethylamino) cyclobutyl]oxy}-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5-yl] ethyl}benzamide::US10174016, Example 165::US10202369, Example 165::US10472354, Example 165 P2X purinoceptor 3 Homo sapiens 81.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319998 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319998&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397549 384223278 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842770 Cc1cnc(s1)-c1cc(O[C@@H]2CCOC2)cc(c1)C(=O)NCc1cnc(nc1)C(F)(F)F InChI=1S/C21H19F3N4O3S/c1-12-7-26-19(32-12)15-4-14(5-17(6-15)31-16-2-3-30-11-16)18(29)25-8-13-9-27-20(28-10-13)21(22,23)24/h4-7,9-10,16H,2-3,8,11H2,1H3,(H,25,29)/t16-/m1/s1 MLKRPMMAEMGGNI-MRXNPFEDSA-N 319999 3-(5-methyl-1,3- thiazol-2-yl)-5- [(3R)- tetrahydrofuran-3- yloxy]-N-{[2- (trifluoromethyl) pyrimidin-5- yl]methyl}benzamide::US10174016, Example 166::US10202369, Example 166::US10472354, Example 166 P2X purinoceptor 3 Homo sapiens 40.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319999 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319999&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397360 384223279 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842772 Cc1cnc(s1)-c1cc(OC2COC2)cc(c1)C(=O)NCc1cnc(nc1)C(F)(F)F InChI=1S/C20H17F3N4O3S/c1-11-5-25-18(31-11)14-2-13(3-15(4-14)30-16-9-29-10-16)17(28)24-6-12-7-26-19(27-8-12)20(21,22)23/h2-5,7-8,16H,6,9-10H2,1H3,(H,24,28) AWMOXCQCRBHEDH-UHFFFAOYSA-N 320000 3-(5-methyl-1,3- thiazol-2-yl)-5- (oxetan-3-yloxy)- N-{[2- (trifluoromethyl) pyrimidin-5- yl]methyl}benzamide::US10174016, Example 167::US10202369, Example 167::US10472354, Example 167 P2X purinoceptor 3 Homo sapiens 72.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320000 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320000&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397228 384223280 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842774 C[C@@H](NC(=O)c1cc(O[C@H]2CN3CCC2CC3)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C25H26F3N5O2S/c1-14-10-29-23(36-14)18-7-17(8-20(9-18)35-21-13-33-5-3-16(21)4-6-33)22(34)32-15(2)19-11-30-24(31-12-19)25(26,27)28/h7-12,15-16,21H,3-6,13H2,1-2H3,(H,32,34)/t15-,21+/m1/s1 XGNFOBIXAZWFEF-VFNWGFHPSA-N 320001 3-[(3R)-1- azabicyclo[2.2.2] oct-3-yloxy]-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 168::US10202369, Example 168::US10472354, Example 168 P2X purinoceptor 3 Homo sapiens 19.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320001 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320001&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397190 384223281 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842776 CCc1cnc(s1)-c1cc(OC2COC2)cc(c1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C22H21F3N4O3S/c1-3-18-9-26-20(33-18)14-4-13(5-16(6-14)32-17-10-31-11-17)19(30)29-12(2)15-7-27-21(28-8-15)22(23,24)25/h4-9,12,17H,3,10-11H2,1-2H3,(H,29,30)/t12-/m1/s1 KJLXSAGNAKDMHX-GFCCVEGCSA-N 320002 3-(5-ethyl-1,3- thiazol-2-yl)-5- (oxetan-3-yloxy)- N-{(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 169::US10202369, Example 169::US10472354, Example 169 P2X purinoceptor 3 Homo sapiens 9.00 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320002 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320002&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397192 384223282 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842778 C[C@@H](NC(=O)c1cc(Oc2ccc(C)nn2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H19F3N6O2S/c1-12-4-5-19(32-31-12)34-18-7-15(6-16(8-18)21-27-9-13(2)35-21)20(33)30-14(3)17-10-28-22(29-11-17)23(24,25)26/h4-11,14H,1-3H3,(H,30,33)/t14-/m1/s1 YBWKZVABJNKBEG-CQSZACIVSA-N 320003 3-[(6- methylpyridazin-3- yl)oxy]-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 170::US10202369, Example 170::US10472354, Example 170 P2X purinoceptor 3 Homo sapiens 165 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320003 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320003&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397298 384223283 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842780 C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ccc(nc1)C(F)F InChI=1S/C23H23F2N3O3S/c1-13-10-27-23(32-13)17-7-16(8-19(9-17)31-18-5-6-30-12-18)22(29)28-14(2)15-3-4-20(21(24)25)26-11-15/h3-4,7-11,14,18,21H,5-6,12H2,1-2H3,(H,28,29)/t14-,18-/m1/s1 UIFKRKFOSZCXTP-RDTXWAMCSA-N 320004 N-{(1R)-1-[6- (difluoromethyl) pyridin-3-yl]ethyl}-3- (5-methyl-1,3- thiazol-2-yl)-5- [(3R)- tetrahydrofuran-3- yloxy]benzamide::US10174016, Example 171::US10202369, Example 171::US10472354, Example 171 P2X purinoceptor 3 Homo sapiens 26.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320004 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320004&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397544 384223284 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842782 C[C@@H](NC(=O)c1cc(O[C@H]2CN3CCC2CC3)cc(c1)-c1ncc(C)s1)c1ccc(nc1)C(F)(F)F InChI=1S/C26H27F3N4O2S/c1-15-12-31-25(36-15)20-9-19(10-21(11-20)35-22-14-33-7-5-17(22)6-8-33)24(34)32-16(2)18-3-4-23(30-13-18)26(27,28)29/h3-4,9-13,16-17,22H,5-8,14H2,1-2H3,(H,32,34)/t16-,22+/m1/s1 BTZKHRISYBAOIH-ZHRRBRCNSA-N 320005 3-[(3R)-1- azabicyclo[2.2.2] oct-3-yloxy]-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[6- (trifluoromethyl) pyridin-3- yl]ethyl}benzamide::US10174016, Example 172::US10202369, Example 172::US10472354, Example 172 P2X purinoceptor 3 Homo sapiens 31.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320005 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320005&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397643 384223285 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842784 CCc1cnc(s1)-c1cc(O[C@@H]2CN3CCC2CC3)cc(c1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C26H28F3N5O2S/c1-3-21-13-30-24(37-21)18-8-17(9-20(10-18)36-22-14-34-6-4-16(22)5-7-34)23(35)33-15(2)19-11-31-25(32-12-19)26(27,28)29/h8-13,15-16,22H,3-7,14H2,1-2H3,(H,33,35)/t15-,22-/m1/s1 SVMXJSAEFPTNIN-IVZQSRNASA-N 320006 3-[(3S)-1- azabicyclo[2.2.2] oct-3-yloxy]-5-(5- ethyl-1,3-thiazol- 2-yl)-N-{(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 173::US10202369, Example 173::US10472354, Example 173 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320006 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320006&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397592 384223286 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842786 CCc1cnc(s1)-c1cc(O[C@H]2CN3CCC2CC3)cc(c1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C26H28F3N5O2S/c1-3-21-13-30-24(37-21)18-8-17(9-20(10-18)36-22-14-34-6-4-16(22)5-7-34)23(35)33-15(2)19-11-31-25(32-12-19)26(27,28)29/h8-13,15-16,22H,3-7,14H2,1-2H3,(H,33,35)/t15-,22+/m1/s1 SVMXJSAEFPTNIN-QRQCRPRQSA-N 320007 3-[(3R)-1- azabicyclo[2.2.2] oct-3-yloxy]-5-(5- ethyl-1,3-thiazol- 2-yl)-N-{(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 174::US10202369, Example 174::US10472354, Example 174 P2X purinoceptor 3 Homo sapiens 11.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320007 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320007&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397479 384223287 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842788 C[C@@H](NC(=O)c1cc(O[C@@H]2CN3CCC2CC3)cc(c1)-c1ncc(C)s1)c1ccc(nc1)C(F)(F)F InChI=1S/C26H27F3N4O2S/c1-15-12-31-25(36-15)20-9-19(10-21(11-20)35-22-14-33-7-5-17(22)6-8-33)24(34)32-16(2)18-3-4-23(30-13-18)26(27,28)29/h3-4,9-13,16-17,22H,5-8,14H2,1-2H3,(H,32,34)/t16-,22-/m1/s1 BTZKHRISYBAOIH-OPAMFIHVSA-N 320008 3-[(3S)-1- azabicyclo[2.2.2] oct-3-yloxy]-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[6- (trifluoromethyl) pyridin-3- yl]ethyl}benzamide::US10174016, Example 175::US10202369, Example 175::US10472354, Example 175 P2X purinoceptor 3 Homo sapiens 23.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320008 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320008&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397558 384223288 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842790 C[C@@H](NC(=O)c1cc(Oc2nnc(C)s2)cc(c1)-c1ncc(C)s1)c1ccc(nc1)C(F)(F)F InChI=1S/C22H18F3N5O2S2/c1-11-9-27-20(33-11)16-6-15(7-17(8-16)32-21-30-29-13(3)34-21)19(31)28-12(2)14-4-5-18(26-10-14)22(23,24)25/h4-10,12H,1-3H3,(H,28,31)/t12-/m1/s1 IWXLKQRNUPTLAV-GFCCVEGCSA-N 320009 3-[(5-methyl- 1,3,4-thiadiazol-2- yl)oxy]-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[6- (trifluoromethyl) pyridin-3- yl]ethyl}benzamide::US10174016, Example 176::US10202369, Example 176::US10472354, Example 176 P2X purinoceptor 3 Homo sapiens 29.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320009 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320009&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397692 384223289 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842792 C[C@@H](NC(=O)c1cc(OC[C@H]2COCCO2)cc(c1)-c1ncc(C)s1)c1ccc(nc1)C(F)(F)F InChI=1S/C24H24F3N3O4S/c1-14-10-29-23(35-14)18-7-17(8-19(9-18)34-13-20-12-32-5-6-33-20)22(31)30-15(2)16-3-4-21(28-11-16)24(25,26)27/h3-4,7-11,15,20H,5-6,12-13H2,1-2H3,(H,30,31)/t15-,20-/m1/s1 LZEBVIBIWJOALL-FOIQADDNSA-N 320010 3-[(2R)-1,4-dioxan-2- ylmethoxy]-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[6- (trifluoromethyl) pyridin-3- yl]ethyl}benzamide::US10174016, Example 177::US10202369, Example 177::US10472354, Example 177 P2X purinoceptor 3 Homo sapiens 14.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320010 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320010&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397515 384223290 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842794 C[C@@H](NC(=O)c1cc(OC[C@H]2COCCO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H23F3N4O4S/c1-13-8-27-21(35-13)16-5-15(6-18(7-16)34-12-19-11-32-3-4-33-19)20(31)30-14(2)17-9-28-22(29-10-17)23(24,25)26/h5-10,14,19H,3-4,11-12H2,1-2H3,(H,30,31)/t14-,19-/m1/s1 NQEFGEXCJWOEFF-AUUYWEPGSA-N 320011 3-[(2R)-1,4-dioxan-2- ylmethoxy]-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 178::US10202369, Example 178::US10472354, Example 178 P2X purinoceptor 3 Homo sapiens 39.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320011 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320011&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397229 384223291 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842796 C[C@@H](NC(=O)c1cc(OC[C@H]2COCCO2)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F InChI=1S/C23H23F3N4O4S/c1-13-10-27-22(35-13)16-7-15(8-17(9-16)34-12-18-11-32-5-6-33-18)21(31)28-14(2)19-3-4-20(30-29-19)23(24,25)26/h3-4,7-10,14,18H,5-6,11-12H2,1-2H3,(H,28,31)/t14-,18-/m1/s1 PZDPWIRLHUGUOG-RDTXWAMCSA-N 320012 3-[(2R)-1,4-dioxan-2- ylmethoxy]-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3-yl]ethyl} benzamide::US10174016, Example 179::US10202369, Example 179::US10472354, Example 179 P2X purinoceptor 3 Homo sapiens 13.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320012 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320012&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397371 384223292 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842798 C[C@@H](NC(=O)c1cc(OC[C@@H]2COCCO2)cc(c1)-c1ncc(C)s1)c1ccc(nc1)C(F)(F)F InChI=1S/C24H24F3N3O4S/c1-14-10-29-23(35-14)18-7-17(8-19(9-18)34-13-20-12-32-5-6-33-20)22(31)30-15(2)16-3-4-21(28-11-16)24(25,26)27/h3-4,7-11,15,20H,5-6,12-13H2,1-2H3,(H,30,31)/t15-,20+/m1/s1 LZEBVIBIWJOALL-QRWLVFNGSA-N 320013 3-[(2S)-1,4-dioxan- 2-ylmethoxy]-5-(5- methyl-1,3-thiazol-2-yl)- N-{(1R)-1-[6- (trifluoromethyl)pyridin- 3-yl]ethyl}benzamide::US10174016, Example 180::US10202369, Example 180::US10472354, Example 180 P2X purinoceptor 3 Homo sapiens 31.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320013 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320013&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397137 384223293 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842800 C[C@@H](NC(=O)c1cc(OC[C@@H]2COCCO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H23F3N4O4S/c1-13-8-27-21(35-13)16-5-15(6-18(7-16)34-12-19-11-32-3-4-33-19)20(31)30-14(2)17-9-28-22(29-10-17)23(24,25)26/h5-10,14,19H,3-4,11-12H2,1-2H3,(H,30,31)/t14-,19+/m1/s1 NQEFGEXCJWOEFF-KUHUBIRLSA-N 320014 3-[(2S)-1,4-dioxan- 2-ylmethoxy]-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 181::US10202369, Example 181::US10472354, Example 181 P2X purinoceptor 3 Homo sapiens 19.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320014 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320014&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397128 384223294 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842802 C[C@@H](NC(=O)c1cc(OC[C@@H]2COCCO2)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F InChI=1S/C23H23F3N4O4S/c1-13-10-27-22(35-13)16-7-15(8-17(9-16)34-12-18-11-32-5-6-33-18)21(31)28-14(2)19-3-4-20(30-29-19)23(24,25)26/h3-4,7-10,14,18H,5-6,11-12H2,1-2H3,(H,28,31)/t14-,18+/m1/s1 PZDPWIRLHUGUOG-KDOFPFPSSA-N 320015 3-[(2S)-1,4-dioxan- 2-ylmethoxy]-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl}benzamide::US10174016, Example 182::US10202369, Example 182::US10472354, Example 182 P2X purinoceptor 3 Homo sapiens 63.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320015 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320015&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397642 384223295 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842804 CC(O)C(C)Oc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1ccc(nn1)C(F)(F)F InChI=1S/C22H23F3N4O3S/c1-11-10-26-21(33-11)16-7-15(8-17(9-16)32-14(4)13(3)30)20(31)27-12(2)18-5-6-19(29-28-18)22(23,24)25/h5-10,12-14,30H,1-4H3,(H,27,31)/t12-,13?,14?/m1/s1 LMHZXBDHIYABCN-IYXRBSQSSA-N 320016 Trans Isomer 1; 3- {[3-hydroxybutan- 2-yl]oxy}-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl}benzamide::US10174016, Example 183::US10202369, Example 230::US10472354, Example 231 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320016 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320016&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397175 384223296 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842806 CC(O)C(C)Oc1cc(cc(c1)-c1ncc(Cl)s1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C21H20ClF3N4O3S/c1-10(15-7-27-20(28-8-15)21(23,24)25)29-18(31)13-4-14(19-26-9-17(22)33-19)6-16(5-13)32-12(3)11(2)30/h4-12,30H,1-3H3,(H,29,31)/t10-,11?,12?/m1/s1 QTLJKKFADUZLKR-VOMCLLRMSA-N 320017 Trans Isomer 1; 3- (5-chloro-1,3- thiazol-2-yl)-5-{[3- hydroxybutan-2- yl]oxy}-N-{(1R)-1- [2-(trifluoromethyl) pyrimidin-5-yl]ethyl} benzamide::US10174016, Example 184::US10174016, Example 185::US10174016, Example 187::US10174016, Example 188::US10202369, Example 188::US10472354, Example 188 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320017 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320017&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397494 384223297 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842808 CC(O)C(C)Oc1cc(cc(c1)-c1ncc(Cl)s1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C21H20ClF3N4O3S/c1-10(15-7-27-20(28-8-15)21(23,24)25)29-18(31)13-4-14(19-26-9-17(22)33-19)6-16(5-13)32-12(3)11(2)30/h4-12,30H,1-3H3,(H,29,31)/t10-,11?,12?/m1/s1 QTLJKKFADUZLKR-VOMCLLRMSA-N 320017 Trans Isomer 1; 3- (5-chloro-1,3- thiazol-2-yl)-5-{[3- hydroxybutan-2- yl]oxy}-N-{(1R)-1- [2-(trifluoromethyl) pyrimidin-5-yl]ethyl} benzamide::US10174016, Example 184::US10174016, Example 185::US10174016, Example 187::US10174016, Example 188::US10202369, Example 188::US10472354, Example 188 P2X purinoceptor 3 Homo sapiens 4.00 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320017 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320017&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397494 384223297 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842810 CC(O)C(C)Oc1cc(cc(c1)-c1ncc(Cl)s1)C(=O)N[C@H](C)c1ccc(nc1)C(F)(F)F InChI=1S/C22H21ClF3N3O3S/c1-11(14-4-5-18(27-9-14)22(24,25)26)29-20(31)15-6-16(21-28-10-19(23)33-21)8-17(7-15)32-13(3)12(2)30/h4-13,30H,1-3H3,(H,29,31)/t11-,12?,13?/m1/s1 HTVWJAQZHONFAU-PNESKVBLSA-N 320019 Trans Isomer 1; 3- (5-chloro-1,3- thiazol-2-yl)-5-{[3- hydroxybutan-2- yl]oxy}-N-{(1R)-1- [6-(trifluoromethyl) pyridin-3-yl]ethyl} benzamide::US10174016, Example 186::US10174016, Example 189::US10202369, Example 189::US10472354, Example 189 P2X purinoceptor 3 Homo sapiens 10.00 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320019 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320019&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397322 384223298 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842812 CC(O)C(C)Oc1cc(cc(c1)-c1ncc(Cl)s1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C21H20ClF3N4O3S/c1-10(15-7-27-20(28-8-15)21(23,24)25)29-18(31)13-4-14(19-26-9-17(22)33-19)6-16(5-13)32-12(3)11(2)30/h4-12,30H,1-3H3,(H,29,31)/t10-,11?,12?/m1/s1 QTLJKKFADUZLKR-VOMCLLRMSA-N 320017 Trans Isomer 1; 3- (5-chloro-1,3- thiazol-2-yl)-5-{[3- hydroxybutan-2- yl]oxy}-N-{(1R)-1- [2-(trifluoromethyl) pyrimidin-5-yl]ethyl} benzamide::US10174016, Example 184::US10174016, Example 185::US10174016, Example 187::US10174016, Example 188::US10202369, Example 188::US10472354, Example 188 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320017 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320017&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397494 384223297 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842814 CC(O)C(C)Oc1cc(cc(c1)-c1ncc(Cl)s1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C21H20ClF3N4O3S/c1-10(15-7-27-20(28-8-15)21(23,24)25)29-18(31)13-4-14(19-26-9-17(22)33-19)6-16(5-13)32-12(3)11(2)30/h4-12,30H,1-3H3,(H,29,31)/t10-,11?,12?/m1/s1 QTLJKKFADUZLKR-VOMCLLRMSA-N 320017 Trans Isomer 1; 3- (5-chloro-1,3- thiazol-2-yl)-5-{[3- hydroxybutan-2- yl]oxy}-N-{(1R)-1- [2-(trifluoromethyl) pyrimidin-5-yl]ethyl} benzamide::US10174016, Example 184::US10174016, Example 185::US10174016, Example 187::US10174016, Example 188::US10202369, Example 188::US10472354, Example 188 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320017 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320017&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397494 384223297 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842816 CC(O)C(C)Oc1cc(cc(c1)-c1ncc(Cl)s1)C(=O)N[C@H](C)c1ccc(nc1)C(F)(F)F InChI=1S/C22H21ClF3N3O3S/c1-11(14-4-5-18(27-9-14)22(24,25)26)29-20(31)15-6-16(21-28-10-19(23)33-21)8-17(7-15)32-13(3)12(2)30/h4-13,30H,1-3H3,(H,29,31)/t11-,12?,13?/m1/s1 HTVWJAQZHONFAU-PNESKVBLSA-N 320019 Trans Isomer 1; 3- (5-chloro-1,3- thiazol-2-yl)-5-{[3- hydroxybutan-2- yl]oxy}-N-{(1R)-1- [6-(trifluoromethyl) pyridin-3-yl]ethyl} benzamide::US10174016, Example 186::US10174016, Example 189::US10202369, Example 189::US10472354, Example 189 P2X purinoceptor 3 Homo sapiens 8.00 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320019 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320019&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397322 384223298 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842818 C[C@@H](NC(=O)c1cc(OC2CCCN(C2)C(=O)OC(C)(C)C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C28H32F3N5O4S/c1-16-12-32-24(41-16)19-9-18(23(37)35-17(2)20-13-33-25(34-14-20)28(29,30)31)10-22(11-19)39-21-7-6-8-36(15-21)26(38)40-27(3,4)5/h9-14,17,21H,6-8,15H2,1-5H3,(H,35,37)/t17-,21?/m1/s1 GMVSECYUKAWWNE-OQHSHRKDSA-N 320023 US10174016, Example 190::US10202369, Example 190::US10472354, Example 190::tert-Butyl (3R)-3-[3-(5-methyl-1,3-thiazol-2-yl)-5-({(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}carbamoyl)phenoxy]piperidine-1-carboxylate, as a mixture of diastereoisomers P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320023 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320023&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134338447 384223299 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842820 CC#CCOc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1ccc(C)nn1 InChI=1S/C22H22N4O2S/c1-5-6-9-28-19-11-17(10-18(12-19)22-23-13-15(3)29-22)21(27)24-16(4)20-8-7-14(2)25-26-20/h7-8,10-13,16H,9H2,1-4H3,(H,24,27)/t16-/m1/s1 WEKOJPFCJMIPGB-MRXNPFEDSA-N 320024 3-(but-2-yn-1- yloxy)-N-[(1R)- 1-(6- methylpyridazin- 3- yl)ethyl]-5- (5-methyl- 1,3-thiazol-2-yl) benzamide::US10174016, Example 191::US10202369, Example 191::US10472354, Example 191 P2X purinoceptor 3 Homo sapiens 61.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320024 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320024&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397657 384223300 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842822 C[C@@H](NC(=O)c1cc(O[C@@H]2CN3CCC2CC3)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C25H26F3N5O2S/c1-14-10-29-23(36-14)18-7-17(8-20(9-18)35-21-13-33-5-3-16(21)4-6-33)22(34)32-15(2)19-11-30-24(31-12-19)25(26,27)28/h7-12,15-16,21H,3-6,13H2,1-2H3,(H,32,34)/t15-,21-/m1/s1 XGNFOBIXAZWFEF-QVKFZJNVSA-N 320025 3-[(3S)-1- azabicyclo[2.2.2] oct-3-yloxy]-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5-yl] ethyl} benzamide::US10174016, Example 192::US10202369, Example 192::US10472354, Example 192 P2X purinoceptor 3 Homo sapiens 12.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320025 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320025&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397263 384223301 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842824 C[C@H](NC(=O)c1cc(OC2COC2)cc(c1)-c1ncc(C)s1)c1nnc(s1)C(F)(F)F InChI=1S/C19H17F3N4O3S2/c1-9-6-23-17(30-9)12-3-11(4-13(5-12)29-14-7-28-8-14)15(27)24-10(2)16-25-26-18(31-16)19(20,21)22/h3-6,10,14H,7-8H2,1-2H3,(H,24,27)/t10-/m0/s1 CAKLWYTTWVXMCY-JTQLQIEISA-N 320027 US10174016, Example 194::US10202369, Example 193::US10472354, Example 193 P2X purinoceptor 3 Homo sapiens 2705 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320027 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320027&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 138374897 384223303 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842826 C[C@@H](NC(=O)c1cc(OC2COC2)cc(c1)-c1ncc(C)s1)c1nnc(s1)C(F)(F)F InChI=1S/C19H17F3N4O3S2/c1-9-6-23-17(30-9)12-3-11(4-13(5-12)29-14-7-28-8-14)15(27)24-10(2)16-25-26-18(31-16)19(20,21)22/h3-6,10,14H,7-8H2,1-2H3,(H,24,27)/t10-/m1/s1 CAKLWYTTWVXMCY-SNVBAGLBSA-N 320026 3-(5-Methyl-1,3-thiazol-2-yl)-5-(oxetan-3-yloxy)-N-{1-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]ethyl}benzamide::US10174016, Example 193::US10202369, Example 194::US10472354, Example 194 P2X purinoceptor 3 Homo sapiens 46.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320026 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320026&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 138374896 384223302 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842828 C[C@H](NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(C)s1)c1nnc(s1)C(F)(F)F InChI=1S/C21H21F3N4O3S2/c1-11-10-25-19(32-11)14-7-13(8-16(9-14)31-15-3-5-30-6-4-15)17(29)26-12(2)18-27-28-20(33-18)21(22,23)24/h7-10,12,15H,3-6H2,1-2H3,(H,26,29)/t12-/m0/s1 NWTVSPCFEGLAFO-LBPRGKRZSA-N 320029 US10174016, Example 196::US10202369, Example 195::US10472354, Example 195 P2X purinoceptor 3 Homo sapiens 380 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320029 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320029&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 138374899 384223305 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842830 C[C@@H](NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(C)s1)c1nnc(s1)C(F)(F)F InChI=1S/C21H21F3N4O3S2/c1-11-10-25-19(32-11)14-7-13(8-16(9-14)31-15-3-5-30-6-4-15)17(29)26-12(2)18-27-28-20(33-18)21(22,23)24/h7-10,12,15H,3-6H2,1-2H3,(H,26,29)/t12-/m1/s1 NWTVSPCFEGLAFO-GFCCVEGCSA-N 320028 3-(5-methyl-1,3-thiazol-2-yl)-5-(tetrahydro-2H-pyran-4-yloxy)-N-{1-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]ethyl}benzamide::US10174016, Example 195::US10202369, Example 196::US10472354, Example 196 P2X purinoceptor 3 Homo sapiens 19.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320028 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320028&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 138374898 384223304 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842832 C[C@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1nnc(s1)C(F)(F)F InChI=1S/C20H19F3N4O3S2/c1-10-8-24-18(31-10)13-5-12(6-15(7-13)30-14-3-4-29-9-14)16(28)25-11(2)17-26-27-19(32-17)20(21,22)23/h5-8,11,14H,3-4,9H2,1-2H3,(H,25,28)/t11-,14+/m0/s1 SHLRNWXFYHGFLL-SMDDNHRTSA-N 320031 US10174016, Example 198::US10202369, Example 197::US10472354, Example 197 P2X purinoceptor 3 Homo sapiens 1152 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320031 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320031&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 138374900 384223307 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842834 C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1nnc(s1)C(F)(F)F InChI=1S/C20H19F3N4O3S2/c1-10-8-24-18(31-10)13-5-12(6-15(7-13)30-14-3-4-29-9-14)16(28)25-11(2)17-26-27-19(32-17)20(21,22)23/h5-8,11,14H,3-4,9H2,1-2H3,(H,25,28)/t11-,14-/m1/s1 SHLRNWXFYHGFLL-BXUZGUMPSA-N 320030 3-(5-methyl-1,3-thiazol-2-yl)-5-[(3R)-tetrahydrofuran-3-yloxy]-N-{1-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]ethyl}benzamide::US10174016, Example 197::US10202369, Example 198::US10472354, Example 198 P2X purinoceptor 3 Homo sapiens 30.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320030 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320030&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397585 384223306 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842836 C[C@H](NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1nnc(s1)C(F)(F)F InChI=1S/C20H19F3N4O3S2/c1-10-8-24-18(31-10)13-5-12(6-15(7-13)30-14-3-4-29-9-14)16(28)25-11(2)17-26-27-19(32-17)20(21,22)23/h5-8,11,14H,3-4,9H2,1-2H3,(H,25,28)/t11-,14-/m0/s1 SHLRNWXFYHGFLL-FZMZJTMJSA-N 320033 US10174016, Example 200::US10202369, Example 199::US10472354, Example 199 P2X purinoceptor 3 Homo sapiens 1544 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320033 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320033&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 138374901 384223309 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842838 C[C@@H](NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1nnc(s1)C(F)(F)F InChI=1S/C20H19F3N4O3S2/c1-10-8-24-18(31-10)13-5-12(6-15(7-13)30-14-3-4-29-9-14)16(28)25-11(2)17-26-27-19(32-17)20(21,22)23/h5-8,11,14H,3-4,9H2,1-2H3,(H,25,28)/t11-,14+/m1/s1 SHLRNWXFYHGFLL-RISCZKNCSA-N 320032 3-(5-methyl-1,3-thiazol-2-yl)-5-[(3S)-tetrahydrofuran-3-yloxy]-N-{1-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]ethyl}benzamide::US10174016, Example 199::US10202369, Example 200::US10472354, Example 200 P2X purinoceptor 3 Homo sapiens 30.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320032 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320032&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397243 384223308 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842840 C[C@@H](NC(=O)c1cc(OC2CCNCC2)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F InChI=1S/C23H24F3N5O2S/c1-13-12-28-22(34-13)16-9-15(10-18(11-16)33-17-5-7-27-8-6-17)21(32)29-14(2)19-3-4-20(31-30-19)23(24,25)26/h3-4,9-12,14,17,27H,5-8H2,1-2H3,(H,29,32)/t14-/m1/s1 JTGZQMREWDOCMX-CQSZACIVSA-N 320034 3-(5-methyl-1,3-thiazol-2-yl)-5-(piperidin-4-yloxy)-N-{(1R)-1-[6-(trifluoromethyl)pyridazin-3-yl]ethyl}benzamide::US10174016, Example 201::US10202369, Example 201::US10472354, Example 201 P2X purinoceptor 3 Homo sapiens 16.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320034 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320034&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397404 384223310 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842842 C[C@@H](NC(=O)c1cc(OC2CC3(CNC3)C2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H24F3N5O2S/c1-13-8-29-21(35-13)16-3-15(4-18(5-16)34-19-6-23(7-19)11-28-12-23)20(33)32-14(2)17-9-30-22(31-10-17)24(25,26)27/h3-5,8-10,14,19,28H,6-7,11-12H2,1-2H3,(H,32,33)/t14-/m1/s1 KMHSWHWDZALJOK-CQSZACIVSA-N 320035 3-(2- azaspiro[3.3] hept- 6-yloxy)-5-(5- methyl-1,3- thiazol-2- yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 202::US10202369, Example 202::US10472354, Example 202 P2X purinoceptor 3 Homo sapiens 42.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320035 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320035&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397731 384223311 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842844 C[C@@H](NC(=O)c1cc(O[C@H]2CCNC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C22H22F3N5O2S/c1-12-8-27-20(33-12)15-5-14(6-18(7-15)32-17-3-4-26-11-17)19(31)30-13(2)16-9-28-21(29-10-16)22(23,24)25/h5-10,13,17,26H,3-4,11H2,1-2H3,(H,30,31)/t13-,17+/m1/s1 IUOVXWVSORDTAX-DYVFJYSZSA-N 320036 3-(5-methyl- 1,3-thiazol-2- yl)-5-[(3S)- pyrrolidin-3- yloxy]-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 203::US10202369, Example 203::US10472354, Example 203 P2X purinoceptor 3 Homo sapiens 36.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320036 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320036&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397829 384223312 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842846 C[C@@H](NC(=O)c1cc(OC2CCNCC2F)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H23F4N5O2S/c1-12-8-29-21(35-12)15-5-14(6-17(7-15)34-19-3-4-28-11-18(19)24)20(33)32-13(2)16-9-30-22(31-10-16)23(25,26)27/h5-10,13,18-19,28H,3-4,11H2,1-2H3,(H,32,33)/t13-,18?,19?/m1/s1 IVYMHMMQRKFONZ-XYJCDUHRSA-N 320037 3-{[3- fluoropiperidin- 4-yl]oxy}-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide, as a mixture of cis isomers::US10174016, Example 204::US10202369, Example 204::US10472354, Example 204 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320037 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320037&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397537 384223313 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842848 C[C@H](NC(=O)c1cc(OC2CCCNC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H24F3N5O2S/c1-13-9-28-21(34-13)16-6-15(7-19(8-16)33-18-4-3-5-27-12-18)20(32)31-14(2)17-10-29-22(30-11-17)23(24,25)26/h6-11,14,18,27H,3-5,12H2,1-2H3,(H,31,32)/t14-,18?/m0/s1 YIMSHVDFMHXVTO-PIVQAISJSA-N 322395 US10183937, Example 206::US10202369, Example 206::US10472354, Example 205 P2X purinoceptor 3 Homo sapiens 4.00 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322395 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322395&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 138375407 384225458 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842850 C[C@@H](NC(=O)c1cc(OC2CCCNC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H24F3N5O2S/c1-13-9-28-21(34-13)16-6-15(7-19(8-16)33-18-4-3-5-27-12-18)20(32)31-14(2)17-10-29-22(30-11-17)23(24,25)26/h6-11,14,18,27H,3-5,12H2,1-2H3,(H,31,32)/t14-,18?/m1/s1 YIMSHVDFMHXVTO-IKJXHCRLSA-N 322394 3-(5-methyl-1,3-thiazol-2-yl)-5-(piperidin-3-yloxy)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10183937, Example 205::US10202369, Example 205::US10472354, Example 206 P2X purinoceptor 3 Homo sapiens 31.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322394 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322394&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397478 384225457 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842852 C[C@H](NC(=O)c1cc(OC2CCNC(C2)C(F)(F)F)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H23F6N5O2S/c1-12-9-32-21(38-12)15-5-14(6-18(7-15)37-17-3-4-31-19(8-17)23(25,26)27)20(36)35-13(2)16-10-33-22(34-11-16)24(28,29)30/h5-7,9-11,13,17,19,31H,3-4,8H2,1-2H3,(H,35,36)/t13-,17?,19?/m0/s1 RLIMWYRKEDYMPQ-LJSZUPLFSA-N 322397 US10183937, Example 208::US10202369, Example 208::US10472354, Example 207 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322397 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322397&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 138375408 384225460 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842854 C[C@@H](NC(=O)c1cc(OC2CCNC(C2)C(F)(F)F)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H23F6N5O2S/c1-12-9-32-21(38-12)15-5-14(6-18(7-15)37-17-3-4-31-19(8-17)23(25,26)27)20(36)35-13(2)16-10-33-22(34-11-16)24(28,29)30/h5-7,9-11,13,17,19,31H,3-4,8H2,1-2H3,(H,35,36)/t13-,17?,19?/m1/s1 RLIMWYRKEDYMPQ-UYCDIGJJSA-N 322396 3-(5-methyl-1,3-thiazol-2-yl)-5-{[2-(trifluoromethyl)piperidin-4-yl]oxy}-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10183937, Example 207::US10202369, Example 207::US10472354, Example 208 P2X purinoceptor 3 Homo sapiens 2.00 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322396 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322396&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397615 384225459 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842856 C[C@@H](NC(=O)c1cc(OC2CC3CC2CN3C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C25H26F3N5O2S/c1-13-9-29-23(36-13)16-4-15(6-20(7-16)35-21-8-19-5-17(21)12-33(19)3)22(34)32-14(2)18-10-30-24(31-11-18)25(26,27)28/h4,6-7,9-11,14,17,19,21H,5,8,12H2,1-3H3,(H,32,34)/t14-,17?,19?,21?/m1/s1 BQHHMEMNTIGDMM-LXOQGKBISA-N 320042 3-{[2-methyl-2-azabicyclo[2.2.1]hept-5-yl]oxy}-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 209::US10202369, Example 209::US10472354, Example 209 P2X purinoceptor 3 Homo sapiens 30.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320042 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320042&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397807 384223318 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842858 C[C@@H](NC(=O)c1cc(OC2CCN(C)CC2)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F InChI=1S/C24H26F3N5O2S/c1-14-13-28-23(35-14)17-10-16(11-19(12-17)34-18-6-8-32(3)9-7-18)22(33)29-15(2)20-4-5-21(31-30-20)24(25,26)27/h4-5,10-13,15,18H,6-9H2,1-3H3,(H,29,33)/t15-/m1/s1 HKVPHDDZBSOGJS-OAHLLOKOSA-N 320043 3-[(1- methylpiperidin- 4-yl)oxy]-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl} benzamide::US10174016, Example 210::US10202369, Example 210::US10472354, Example 210 P2X purinoceptor 3 Homo sapiens 12.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320043 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320043&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397346 384223319 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842860 C[C@@H](NC(=O)c1cc(OC2CN(C)C2)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F InChI=1S/C22H22F3N5O2S/c1-12-9-26-21(33-12)15-6-14(7-16(8-15)32-17-10-30(3)11-17)20(31)27-13(2)18-4-5-19(29-28-18)22(23,24)25/h4-9,13,17H,10-11H2,1-3H3,(H,27,31)/t13-/m1/s1 IRYKBWGBPIOTOU-CYBMUJFWSA-N 320044 3-[(1- methylazetidin- 3-yl)oxy]-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl} benzamide::US10174016, Example 211::US10202369, Example 211::US10472354, Example 211 P2X purinoceptor 3 Homo sapiens 395 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320044 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320044&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397301 384223320 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842862 C[C@@H](NC(=O)c1cc(OC2CCN(C)CC2F)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H25F4N5O2S/c1-13-9-29-22(36-13)16-6-15(7-18(8-16)35-20-4-5-33(3)12-19(20)25)21(34)32-14(2)17-10-30-23(31-11-17)24(26,27)28/h6-11,14,19-20H,4-5,12H2,1-3H3,(H,32,34)/t14-,19?,20?/m1/s1 XFFHESNTQMKRAI-WPUWVODUSA-N 320045 3-[(3-fluoro-1- methylpiperidin-4- yl)oxy]-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide, as a single unknown isomer::US10174016, Example 212::US10202369, Example 212::US10472354, Example 212 P2X purinoceptor 3 Homo sapiens 4.00 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320045 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320045&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397317 384223321 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842864 C[C@@H](NC(=O)c1cc(OCC2(CC2)N(C)C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H26F3N5O2S/c1-14-10-28-21(35-14)17-7-16(8-19(9-17)34-13-23(5-6-23)32(3)4)20(33)31-15(2)18-11-29-22(30-12-18)24(25,26)27/h7-12,15H,5-6,13H2,1-4H3,(H,31,33)/t15-/m1/s1 GWFQILAPUSJPLG-OAHLLOKOSA-N 320046 3-{[1- (dimethylamino) cyclopropyl] methoxy}- 5-(5-methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 213::US10202369, Example 213::US10472354, Example 213 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320046 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320046&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397636 384223322 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842866 C[C@@H](NC(=O)c1cc(OC2CC3(C2)CN(C)C3)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C25H26F3N5O2S/c1-14-9-29-22(36-14)17-4-16(5-19(6-17)35-20-7-24(8-20)12-33(3)13-24)21(34)32-15(2)18-10-30-23(31-11-18)25(26,27)28/h4-6,9-11,15,20H,7-8,12-13H2,1-3H3,(H,32,34)/t15-/m1/s1 HKONVGJPBICXCZ-OAHLLOKOSA-N 320047 3-[(2-methyl-2- azaspiro [3.3]hept- 6-yl)oxy]-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 214::US10202369, Example 214::US10472354, Example 214 P2X purinoceptor 3 Homo sapiens 47.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320047 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320047&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397792 384223323 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842868 C[C@@H](NC(=O)c1cc(OC2CCN(C)CC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H26F3N5O2S/c1-14-11-28-22(35-14)17-8-16(9-20(10-17)34-19-4-6-32(3)7-5-19)21(33)31-15(2)18-12-29-23(30-13-18)24(25,26)27/h8-13,15,19H,4-7H2,1-3H3,(H,31,33)/t15-/m1/s1 BKNIRTNEYAOJDL-OAHLLOKOSA-N 319972 3-[(1-Methylpiperidin-4-yl)oxy]-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 139::US10202369, Example 139::US10472354, Example 215 P2X purinoceptor 3 Homo sapiens 16.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319972 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319972&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397521 384223252 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842870 C[C@@H](NC(=O)c1cc(O[C@@H]2C[C@@H]3CC[C@H](C2)N3C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C26H28F3N5O2S/c1-14-11-30-24(37-14)17-6-16(7-21(8-17)36-22-9-19-4-5-20(10-22)34(19)3)23(35)33-15(2)18-12-31-25(32-13-18)26(27,28)29/h6-8,11-13,15,19-20,22H,4-5,9-10H2,1-3H3,(H,33,35)/t15-,19-,20+,22+/m1/s1 BLUSEIUVKSVVTE-DZUANBCISA-N 320049 3-{[(3-endo)-8- methyl-8- azabicyclo[3.2.1] oct-3-yl]oxy}-5- (5-methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 216::US10202369, Example 216::US10472354, Example 216 P2X purinoceptor 3 Homo sapiens 14.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320049 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320049&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397314 384223325 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842872 C[C@@H](NC(=O)c1cc(O[C@H]2C[C@@H]3CC[C@H](C2)N3C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C26H28F3N5O2S/c1-14-11-30-24(37-14)17-6-16(7-21(8-17)36-22-9-19-4-5-20(10-22)34(19)3)23(35)33-15(2)18-12-31-25(32-13-18)26(27,28)29/h6-8,11-13,15,19-20,22H,4-5,9-10H2,1-3H3,(H,33,35)/t15-,19-,20+,22-/m1/s1 BLUSEIUVKSVVTE-BWKKGPAXSA-N 320050 3-{[(3-exo)-8- methyl-8- azabicyclo[3.2.1] oct-3-yl]oxy}- 5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 217::US10202369, Example 217::US10472354, Example 217 P2X purinoceptor 3 Homo sapiens 25.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320050 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320050&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397314 384223326 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842874 C[C@@H](NC(=O)c1cc(O[C@@H]2CC[C@H]3[C@H]2OCCN3C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C26H28F3N5O3S/c1-14-11-30-24(38-14)17-8-16(23(35)33-15(2)18-12-31-25(32-13-18)26(27,28)29)9-19(10-17)37-21-5-4-20-22(21)36-7-6-34(20)3/h8-13,15,20-22H,4-7H2,1-3H3,(H,33,35)/t15-,20+,21-,22-/m1/s1 FEZSJTOXTJNSGQ-WWGKXEARSA-N 320051 3-{[(4aS,7R, 7aR)-4- methyloctahydro- cyclopenta [b][1,4] oxazin-7-yl] oxy}-5- (5-methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 218::US10202369, Example 218::US10472354, Example 218 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320051 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320051&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397834 384223327 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842876 C[C@@H](NC(=O)c1cc(O[C@H]2CC[C@H]3[C@H]2OCCN3C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C26H28F3N5O3S/c1-14-11-30-24(38-14)17-8-16(23(35)33-15(2)18-12-31-25(32-13-18)26(27,28)29)9-19(10-17)37-21-5-4-20-22(21)36-7-6-34(20)3/h8-13,15,20-22H,4-7H2,1-3H3,(H,33,35)/t15-,20+,21+,22-/m1/s1 FEZSJTOXTJNSGQ-NSEXGNSCSA-N 320052 3-{[(4aS,7S, 7aR)-4- methylocta- hydro- cyclopenta[b] [1,4]oxazin- 7-yl]oxy}-5- (5-methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 219::US10202369, Example 219::US10472354, Example 219 P2X purinoceptor 3 Homo sapiens 2.00 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320052 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320052&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397597 384223328 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842878 C[C@H](NC(=O)c1cc(OC2CCCN(C)C2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H26F3N5O2S/c1-14-10-28-22(35-14)17-7-16(8-20(9-17)34-19-5-4-6-32(3)13-19)21(33)31-15(2)18-11-29-23(30-12-18)24(25,26)27/h7-12,15,19H,4-6,13H2,1-3H3,(H,31,33)/t15-,19?/m0/s1 DNVWWBHMIGZIMX-FUKCDUGKSA-N 322410 US10183937, Example 221::US10202369, Example 221::US10472354, Example 220 P2X purinoceptor 3 Homo sapiens 62.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322410 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322410&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 138375409 384225472 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842880 C[C@@H](NC(=O)c1cc(OC2CCCN(C)C2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H26F3N5O2S/c1-14-10-28-22(35-14)17-7-16(8-20(9-17)34-19-5-4-6-32(3)13-19)21(33)31-15(2)18-11-29-23(30-12-18)24(25,26)27/h7-12,15,19H,4-6,13H2,1-3H3,(H,31,33)/t15-,19?/m1/s1 DNVWWBHMIGZIMX-NYRJJRHWSA-N 322409 3-[(1-methylpiperidin-3-yl)oxy]-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10183937, Example 220::US10202369, Example 220::US10472354, Example 221 P2X purinoceptor 3 Homo sapiens 26.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322409 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322409&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397678 384225471 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842882 C[C@H](NC(=O)c1cc(OC2CCN(C)C(C2)C(F)(F)F)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C25H25F6N5O2S/c1-13-10-32-22(39-13)16-6-15(21(37)35-14(2)17-11-33-23(34-12-17)25(29,30)31)7-19(8-16)38-18-4-5-36(3)20(9-18)24(26,27)28/h6-8,10-12,14,18,20H,4-5,9H2,1-3H3,(H,35,37)/t14-,18?,20?/m0/s1 ALJCLRFXPKVCLC-KLOIUYPJSA-N 322412 US10183937, Example 223::US10202369, Example 223::US10472354, Example 222 P2X purinoceptor 3 Homo sapiens 4.00 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322412 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322412&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 138375410 384225474 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842884 C[C@@H](NC(=O)c1cc(OC2CCN(C)C(C2)C(F)(F)F)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C25H25F6N5O2S/c1-13-10-32-22(39-13)16-6-15(21(37)35-14(2)17-11-33-23(34-12-17)25(29,30)31)7-19(8-16)38-18-4-5-36(3)20(9-18)24(26,27)28/h6-8,10-12,14,18,20H,4-5,9H2,1-3H3,(H,35,37)/t14-,18?,20?/m1/s1 ALJCLRFXPKVCLC-FHTBDLFWSA-N 322411 3-(5-methyl-1,3-thiazol-2-yl)-5-{[1-methyl-2-(trifluoromethyl)piperidin-4-yl]oxy}-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10183937, Example 222::US10202369, Example 222::US10472354, Example 223 P2X purinoceptor 3 Homo sapiens 3.00 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322411 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322411&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397819 384225473 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842886 CC(C)N1CCC(CC1)Oc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1ccc(nn1)C(F)(F)F InChI=1S/C26H30F3N5O2S/c1-15(2)34-9-7-20(8-10-34)36-21-12-18(11-19(13-21)25-30-14-16(3)37-25)24(35)31-17(4)22-5-6-23(33-32-22)26(27,28)29/h5-6,11-15,17,20H,7-10H2,1-4H3,(H,31,35)/t17-/m1/s1 KRNISEGUXIGIEE-QGZVFWFLSA-N 320057 3-(5-Methyl-1,3-thiazol-2-yl)-5-{[1-(propan-2-yl)piperidin-4-yl]oxy}-N-{(1R)-1-[6-(trifluoromethyl)pyridazin-3-yl]ethyl}benzamide::US10174016, Example 224::US10202369, Example 224::US10472354, Example 224 P2X purinoceptor 3 Homo sapiens 9.00 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320057 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320057&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397429 384223331 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842888 CC(C)N1CC[C@@H](C1)Oc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C25H28F3N5O2S/c1-14(2)33-6-5-20(13-33)35-21-8-17(7-18(9-21)23-29-10-15(3)36-23)22(34)32-16(4)19-11-30-24(31-12-19)25(26,27)28/h7-12,14,16,20H,5-6,13H2,1-4H3,(H,32,34)/t16-,20+/m1/s1 AIBFTYSUMUVEOU-UZLBHIALSA-N 320058 3-(5-methyl- 1,3-thiazol- 2-yl)-5- {[(3S)-1- (propan-2- yl)pyrrolidin- 3-yl]oxy}-N- {(1R)-1- [2-(trifluoro- methyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 225::US10202369, Example 225::US10472354, Example 225 P2X purinoceptor 3 Homo sapiens 16.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320058 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320058&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397786 384223332 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842890 COC(=O)N1CCC(CC1)Oc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C25H26F3N5O4S/c1-14-11-29-22(38-14)17-8-16(9-20(10-17)37-19-4-6-33(7-5-19)24(35)36-3)21(34)32-15(2)18-12-30-23(31-13-18)25(26,27)28/h8-13,15,19H,4-7H2,1-3H3,(H,32,34)/t15-/m1/s1 XKGQQPBORAHPPR-OAHLLOKOSA-N 320059 Methyl 4-[3-(5-methyl-1,3-thiazol-2-yl)-5-({(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}carbamoyl)phenoxy]piperidine-1-carboxylate::US10174016, Example 226::US10202369, Example 226::US10472354, Example 226 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320059 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320059&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397135 384223333 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842892 CCOC(=O)N1CCC(CC1)Oc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C26H28F3N5O4S/c1-4-37-25(36)34-7-5-20(6-8-34)38-21-10-17(9-18(11-21)23-30-12-15(2)39-23)22(35)33-16(3)19-13-31-24(32-14-19)26(27,28)29/h9-14,16,20H,4-8H2,1-3H3,(H,33,35)/t16-/m1/s1 VLNWCOYPKWPZPZ-MRXNPFEDSA-N 320060 Ethyl 4-[3-(5-methyl-1,3-thiazol-2-yl)-5-({(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}carbamoyl)phenoxy]piperidine-1-carboxylate::US10174016, Example 227::US10202369, Example 227::US10472354, Example 227 P2X purinoceptor 3 Homo sapiens 13.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320060 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320060&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397225 384223334 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842894 CCOC(=O)N1CC[C@@H](C1)Oc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C25H26F3N5O4S/c1-4-36-24(35)33-6-5-19(13-33)37-20-8-16(7-17(9-20)22-29-10-14(2)38-22)21(34)32-15(3)18-11-30-23(31-12-18)25(26,27)28/h7-12,15,19H,4-6,13H2,1-3H3,(H,32,34)/t15-,19+/m1/s1 ZKABVOKJBCLEBM-BEFAXECRSA-N 320061 Ethyl (3S)-3-[3-(5-methyl-1,3-thiazol-2-yl)-5-({(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}carbamoyl)phenoxy]pyrrolidine-1-carboxylate::US10174016, Example 228::US10202369, Example 228::US10472354, Example 228 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320061 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320061&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134338446 384223335 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842896 CC(C)N1CC(C1)Oc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C24H26F3N5O2S/c1-13(2)32-11-20(12-32)34-19-6-16(5-17(7-19)22-28-8-14(3)35-22)21(33)31-15(4)18-9-29-23(30-10-18)24(25,26)27/h5-10,13,15,20H,11-12H2,1-4H3,(H,31,33)/t15-/m1/s1 ZGCTZBYNIOVVEC-OAHLLOKOSA-N 320062 3-(5-Methyl-1,3-thiazol-2-yl)-5-{[1-(propan-2-yl)azetidin-3-yl]oxy}-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 229::US10202369, Example 229::US10472354, Example 229 P2X purinoceptor 3 Homo sapiens 44.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320062 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320062&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397633 384223336 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842898 CC(O)C(C)Oc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@@H](C)c1ccc(nn1)C(F)(F)F InChI=1S/C22H23F3N4O3S/c1-11-10-26-21(33-11)16-7-15(8-17(9-16)32-14(4)13(3)30)20(31)27-12(2)18-5-6-19(29-28-18)22(23,24)25/h5-10,12-14,30H,1-4H3,(H,27,31)/t12-,13?,14?/m0/s1 LMHZXBDHIYABCN-HSBZDZAISA-N 322420 US10183937, Example 231::US10202369, Example 231::US10472354, Example 230 P2X purinoceptor 3 Homo sapiens 2.00 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322420 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322420&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 138375411 384225482 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842900 CC(O)C(C)Oc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1ccc(nn1)C(F)(F)F InChI=1S/C22H23F3N4O3S/c1-11-10-26-21(33-11)16-7-15(8-17(9-16)32-14(4)13(3)30)20(31)27-12(2)18-5-6-19(29-28-18)22(23,24)25/h5-10,12-14,30H,1-4H3,(H,27,31)/t12-,13?,14?/m1/s1 LMHZXBDHIYABCN-IYXRBSQSSA-N 320016 Trans Isomer 1; 3- {[3-hydroxybutan- 2-yl]oxy}-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl}benzamide::US10174016, Example 183::US10202369, Example 230::US10472354, Example 231 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320016 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320016&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397175 384223296 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842902 C[C@@H](NC(=O)c1cc(OC2CCS(=O)(=O)CC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H23F3N4O4S2/c1-13-10-27-21(35-13)16-7-15(8-19(9-16)34-18-3-5-36(32,33)6-4-18)20(31)30-14(2)17-11-28-22(29-12-17)23(24,25)26/h7-12,14,18H,3-6H2,1-2H3,(H,30,31)/t14-/m1/s1 JTWSIDWRGZSZAA-CQSZACIVSA-N 320065 3-[(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)oxy]-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 232::US10202369, Example 232::US10472354, Example 232 P2X purinoceptor 3 Homo sapiens 13.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320065 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320065&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397851 384223339 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842904 C[C@@H](NC(=O)c1cc(OC2CCS(=O)(=O)CC2)cc(c1)-c1ncc(C)s1)c1ccc(nc1)C(F)(F)F InChI=1S/C24H24F3N3O4S2/c1-14-12-29-23(35-14)18-9-17(10-20(11-18)34-19-5-7-36(32,33)8-6-19)22(31)30-15(2)16-3-4-21(28-13-16)24(25,26)27/h3-4,9-13,15,19H,5-8H2,1-2H3,(H,30,31)/t15-/m1/s1 BRFDVYQZWOBZCT-OAHLLOKOSA-N 320066 3-[(1,1- dioxidotetrahydro- 2H-thiopyran-4- yl)oxy]-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[6- (trifluoromethyl) pyridin-3-yl]ethyl} benzamide::US10174016, Example 233::US10202369, Example 233::US10472354, Example 233 P2X purinoceptor 3 Homo sapiens 16.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320066 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320066&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397139 384223340 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842906 CCc1cnc(s1)-c1cc(OC2CCOCC2)cc(c1)C(=O)N[C@H](C)c1cnc(C)cn1 InChI=1S/C24H28N4O3S/c1-4-21-13-27-24(32-21)18-9-17(10-20(11-18)31-19-5-7-30-8-6-19)23(29)28-16(3)22-14-25-15(2)12-26-22/h9-14,16,19H,4-8H2,1-3H3,(H,28,29)/t16-/m1/s1 DYONOLZVTXITOM-MRXNPFEDSA-N 320067 3-(5-ethyl-1,3- thiazol-2-yl)-N- [(1R)-1-(5- methylpyrazin-2- yl)ethyl]-5- (tetrahydro-2H- pyran-4- yloxy)benzamide::US10174016, Example 234::US10202369, Example 234::US10472354, Example 234 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320067 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320067&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397540 384223341 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842908 CCc1cnc(s1)-c1cc(OC2CCOCC2)cc(c1)C(=O)NCc1ccc(C)nn1 InChI=1S/C23H26N4O3S/c1-3-21-14-25-23(31-21)17-10-16(11-20(12-17)30-19-6-8-29-9-7-19)22(28)24-13-18-5-4-15(2)26-27-18/h4-5,10-12,14,19H,3,6-9,13H2,1-2H3,(H,24,28) BZFPOECMUNEZDH-UHFFFAOYSA-N 320068 3-(5-ethyl-1,3- thiazol-2-yl)-N-[(6- methylpyridazin-3- yl)methyl]-5- (tetrahydro-2H- pyran-4- yloxy)benzamide::US10174016, Example 235::US10202369, Example 235::US10472354, Example 235 P2X purinoceptor 3 Homo sapiens 18.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320068 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320068&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397197 384223342 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842910 C[C@@H](NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(s1)C1CCC1)c1cnc(C)cn1 InChI=1S/C26H30N4O3S/c1-16-13-28-23(14-27-16)17(2)30-25(31)19-10-20(26-29-15-24(34-26)18-4-3-5-18)12-22(11-19)33-21-6-8-32-9-7-21/h10-15,17-18,21H,3-9H2,1-2H3,(H,30,31)/t17-/m1/s1 QOZNFPLCSPWJRX-QGZVFWFLSA-N 320069 3-(5-cyclobutyl- 1,3-thiazol-2-yl)- N-[(1R)-1-(5- methylpyrazin-2- yl)ethyl]-5- (tetrahydro-2H- pyran-4- yloxy)benzamide::US10174016, Example 236::US10202369, Example 236::US10472354, Example 236 P2X purinoceptor 3 Homo sapiens 76.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320069 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320069&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397529 384223343 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842912 Cc1ccc(CNC(=O)c2cc(OC3CCOCC3)cc(c2)-c2ncc(s2)C2CCC2)nn1 InChI=1S/C25H28N4O3S/c1-16-5-6-20(29-28-16)14-26-24(30)18-11-19(25-27-15-23(33-25)17-3-2-4-17)13-22(12-18)32-21-7-9-31-10-8-21/h5-6,11-13,15,17,21H,2-4,7-10,14H2,1H3,(H,26,30) KYDTWNODFNIYNY-UHFFFAOYSA-N 320070 3-(5-cyclobutyl- 1,3-thiazol-2-yl)- N-[(6- methylpyridazin-3- yl)methyl]-5- (tetrahydro-2H- pyran-4- yloxy)benzamide::US10174016, Example 237::US10202369, Example 237::US10472354, Example 237 P2X purinoceptor 3 Homo sapiens 177 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320070 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320070&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397323 384223344 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842914 C[C@@H](NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(s1)C1CCC1)c1cnc(nc1)C(F)(F)F InChI=1S/C26H27F3N4O3S/c1-15(19-12-31-25(32-13-19)26(27,28)29)33-23(34)17-9-18(24-30-14-22(37-24)16-3-2-4-16)11-21(10-17)36-20-5-7-35-8-6-20/h9-16,20H,2-8H2,1H3,(H,33,34)/t15-/m1/s1 KTFAMKPHNDUKLL-OAHLLOKOSA-N 320071 3-(5-cyclobutyl- 1,3-thiazol-2-yl)-5- (tetrahydro-2H- pyran-4-yloxy)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 238::US10202369, Example 238::US10472354, Example 238 P2X purinoceptor 3 Homo sapiens 38.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320071 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320071&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397176 384223345 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842916 C[C@H](NC(=O)c1cc(OC[C@H]2CCOC2)cc(c1)-c1ncc(s1)C1CCC1)c1cnc(nc1)C(F)(F)F InChI=1S/C26H27F3N4O3S/c1-15(20-10-31-25(32-11-20)26(27,28)29)33-23(34)18-7-19(24-30-12-22(37-24)17-3-2-4-17)9-21(8-18)36-14-16-5-6-35-13-16/h7-12,15-17H,2-6,13-14H2,1H3,(H,33,34)/t15-,16-/m0/s1 JWRPHAGJMIAQMD-HOTGVXAUSA-N 320072 3-(5-cyclobutyl- 1,3-thiazol-2-yl)-5- [(3S)- tetrahydrofuran-3- ylmethoxy]-N- {(1S)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 239::US10202369, Example 239::US10472354, Example 239 P2X purinoceptor 3 Homo sapiens 1420 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320072 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320072&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397719 384223346 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842918 CCc1cnc(s1)-c1cc(O[C@@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1ccc(C)nn1 InChI=1S/C23H26N4O3S/c1-4-20-12-24-23(31-20)17-9-16(10-19(11-17)30-18-7-8-29-13-18)22(28)25-15(3)21-6-5-14(2)26-27-21/h5-6,9-12,15,18H,4,7-8,13H2,1-3H3,(H,25,28)/t15-,18-/m1/s1 OXXUGGORGDKECE-CRAIPNDOSA-N 320073 3-(5-ethyl-1,3- thiazol-2-yl)-N- [(1R)-1-(6- methylpyridazin-3- yl)ethyl]-5-[(3R)- tetrahydrofuran-3- yloxy]benzamide::US10174016, Example 240::US10202369, Example 249::US10472354, Example 240 P2X purinoceptor 3 Homo sapiens 12.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320073 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320073&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397178 384223347 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842920 CCc1cnc(s1)-c1cc(O[C@@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1cnc(C)cn1 InChI=1S/C23H26N4O3S/c1-4-20-11-26-23(31-20)17-7-16(8-19(9-17)30-18-5-6-29-13-18)22(28)27-15(3)21-12-24-14(2)10-25-21/h7-12,15,18H,4-6,13H2,1-3H3,(H,27,28)/t15-,18-/m1/s1 GGGFDTSSCKHCGY-CRAIPNDOSA-N 320074 3-(5-ethyl-1,3- thiazol-2-yl)-N- [(1R)-1-(5- methylpyrazin-2- yl)ethyl]-5-[(3R)- tetrahydrofuran-3- yloxy]benzamide::US10174016, Example 241::US10202369, Example 241::US10472354, Example 241 P2X purinoceptor 3 Homo sapiens 12.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320074 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320074&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397675 384223348 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842922 CCc1cnc(s1)-c1cc(O[C@@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C23H23F3N4O3S/c1-3-19-11-27-21(34-19)15-6-14(7-18(8-15)33-17-4-5-32-12-17)20(31)30-13(2)16-9-28-22(29-10-16)23(24,25)26/h6-11,13,17H,3-5,12H2,1-2H3,(H,30,31)/t13-,17-/m1/s1 CPHCWMUXIASQAI-CXAGYDPISA-N 320075 3-(5-ethyl-1,3- thiazol-2-yl)-5- [(3R)- tetrahydrofuran-3- yloxy]-N-{(1R)-1- [2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 242::US10202369, Example 242::US10472354, Example 242 P2X purinoceptor 3 Homo sapiens 2.00 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320075 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320075&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397732 384223349 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842924 C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(s1)C1CCC1)c1ccc(C)nn1 InChI=1S/C25H28N4O3S/c1-15-6-7-22(29-28-15)16(2)27-24(30)18-10-19(12-21(11-18)32-20-8-9-31-14-20)25-26-13-23(33-25)17-4-3-5-17/h6-7,10-13,16-17,20H,3-5,8-9,14H2,1-2H3,(H,27,30)/t16-,20-/m1/s1 GBDWWYIZWHGLEN-OXQOHEQNSA-N 320076 3-(5-cyclobutyl- 1,3-thiazol-2-yl)- N-[(1R)-1-(6- methylpyridazin-3- yl)ethyl]-5-[(3R)- tetrahydrofuran-3- yloxy]benzamide::US10174016, Example 243::US10202369, Example 243::US10472354, Example 243 P2X purinoceptor 3 Homo sapiens 117 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320076 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320076&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397824 384223350 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842926 C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(s1)C1CCC1)c1cnc(C)cn1 InChI=1S/C25H28N4O3S/c1-15-11-27-22(12-26-15)16(2)29-24(30)18-8-19(10-21(9-18)32-20-6-7-31-14-20)25-28-13-23(33-25)17-4-3-5-17/h8-13,16-17,20H,3-7,14H2,1-2H3,(H,29,30)/t16-,20-/m1/s1 FVGXVLFIHFQXPP-OXQOHEQNSA-N 320077 3-(5-cyclobutyl- 1,3-thiazol-2-yl)- N-[(1R)-1-(5- methylpyrazin-2- yl)ethyl]-5-[(3R)- tetrahydrofuran-3- yloxy]benzamide::US10174016, Example 244::US10202369, Example 244::US10472354, Example 244 P2X purinoceptor 3 Homo sapiens 75.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320077 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320077&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397416 384223351 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842928 C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(s1)C1CCC1)c1cnc(nc1)C(F)(F)F InChI=1S/C25H25F3N4O3S/c1-14(18-10-30-24(31-11-18)25(26,27)28)32-22(33)16-7-17(9-20(8-16)35-19-5-6-34-13-19)23-29-12-21(36-23)15-3-2-4-15/h7-12,14-15,19H,2-6,13H2,1H3,(H,32,33)/t14-,19-/m1/s1 IDGMWIXZIVCDCF-AUUYWEPGSA-N 320078 3-(5-cyclobutyl- 1,3-thiazol-2-yl)-5- [(3R)- tetrahydrofuran-3- yloxy]-N-{(1R)-1- [2-(trifluoromethyl) pyrimidin-5-yl] ethyl}benzamide::US10174016, Example 245::US10202369, Example 245::US10472354, Example 245 P2X purinoceptor 3 Homo sapiens 34.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320078 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320078&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397471 384223352 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842930 CC(C)c1cnc(s1)-c1cc(O[C@@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1ccc(C)nn1 InChI=1S/C24H28N4O3S/c1-14(2)22-12-25-24(32-22)18-9-17(10-20(11-18)31-19-7-8-30-13-19)23(29)26-16(4)21-6-5-15(3)27-28-21/h5-6,9-12,14,16,19H,7-8,13H2,1-4H3,(H,26,29)/t16-,19-/m1/s1 AZADLHFQZQVHQV-VQIMIIECSA-N 320079 N-[(1R)-1-(6- methylpyridazin-3- yl)ethyl]-3-[5- (propan-2-yl)-1,3- thiazol-2-yl]-5- [(3R)- tetrahydrofuran-3- yloxy]benzamide::US10174016, Example 246::US10202369, Example 246::US10472354, Example 246 P2X purinoceptor 3 Homo sapiens 266 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320079 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320079&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397745 384223353 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842932 CC(C)c1cnc(s1)-c1cc(O[C@@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1cnc(C)cn1 InChI=1S/C24H28N4O3S/c1-14(2)22-12-27-24(32-22)18-7-17(8-20(9-18)31-19-5-6-30-13-19)23(29)28-16(4)21-11-25-15(3)10-26-21/h7-12,14,16,19H,5-6,13H2,1-4H3,(H,28,29)/t16-,19-/m1/s1 ULUQVVVXKLITBV-VQIMIIECSA-N 320080 N-[(1R)-1-(5- methylpyrazin-2- yl)ethyl]-3-[5- (propan-2-yl)-1,3- thiazol-2-yl]-5- [(3R)- tetrahydrofuran-3- yloxy]benzamide::US10174016, Example 247::US10202369, Example 247::US10472354, Example 247 P2X purinoceptor 3 Homo sapiens 205 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320080 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320080&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397213 384223354 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842934 CC(C)c1cnc(s1)-c1cc(O[C@@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C24H25F3N4O3S/c1-13(2)20-11-28-22(35-20)16-6-15(7-19(8-16)34-18-4-5-33-12-18)21(32)31-14(3)17-9-29-23(30-10-17)24(25,26)27/h6-11,13-14,18H,4-5,12H2,1-3H3,(H,31,32)/t14-,18-/m1/s1 COCLYUAEQYUAPW-RDTXWAMCSA-N 320081 3-[5-(propan-2-yl)- 1,3-thiazol-2-yl]-5- [(3R)- tetrahydrofuran-3- yloxy]-N-{(1R)-1- [2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 248::US10202369, Example 248::US10472354, Example 248 P2X purinoceptor 3 Homo sapiens 44.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320081 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320081&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397577 384223355 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842936 CCc1cnc(s1)-c1cc(O[C@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1ccc(C)nn1 InChI=1S/C23H26N4O3S/c1-4-20-12-24-23(31-20)17-9-16(10-19(11-17)30-18-7-8-29-13-18)22(28)25-15(3)21-6-5-14(2)26-27-21/h5-6,9-12,15,18H,4,7-8,13H2,1-3H3,(H,25,28)/t15-,18+/m1/s1 OXXUGGORGDKECE-QAPCUYQASA-N 320082 3-(5-ethyl-1,3- thiazol-2-yl)-N- [(1R)-1-(6- methylpyridazin-3- yl)ethyl]-5-[(3S)- tetrahydrofuran-3- yloxy]benzamide::US10174016, Example 249::US10472354, Example 249 P2X purinoceptor 3 Homo sapiens 11.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320082 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320082&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397606 384223356 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842938 CCc1cnc(s1)-c1cc(O[C@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1cnc(C)cn1 InChI=1S/C23H26N4O3S/c1-4-20-11-26-23(31-20)17-7-16(8-19(9-17)30-18-5-6-29-13-18)22(28)27-15(3)21-12-24-14(2)10-25-21/h7-12,15,18H,4-6,13H2,1-3H3,(H,27,28)/t15-,18+/m1/s1 GGGFDTSSCKHCGY-QAPCUYQASA-N 320083 3-(5-ethyl-1,3- thiazol-2-yl)-N- [(1R)-1-(5- methylpyrazin-2- yl)ethyl]-5-[(3S)- tetrahydrofuran-3- yloxy]benzamide::US10174016, Example 250::US10202369, Example 250::US10472354, Example 250 P2X purinoceptor 3 Homo sapiens 15.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320083 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320083&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397653 384223357 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842940 CCc1cnc(s1)-c1cc(O[C@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C23H23F3N4O3S/c1-3-19-11-27-21(34-19)15-6-14(7-18(8-15)33-17-4-5-32-12-17)20(31)30-13(2)16-9-28-22(29-10-16)23(24,25)26/h6-11,13,17H,3-5,12H2,1-2H3,(H,30,31)/t13-,17+/m1/s1 CPHCWMUXIASQAI-DYVFJYSZSA-N 320084 3-(5-ethyl-1,3- thiazol-2-yl)-5- [(3S)- tetrahydrofuran-3- yloxy]-N-{(1R)-1- [2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 251::US10202369, Example 251::US10472354, Example 251 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320084 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320084&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397624 384223358 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842942 C[C@@H](NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(s1)C1CCC1)c1ccc(C)nn1 InChI=1S/C25H28N4O3S/c1-15-6-7-22(29-28-15)16(2)27-24(30)18-10-19(12-21(11-18)32-20-8-9-31-14-20)25-26-13-23(33-25)17-4-3-5-17/h6-7,10-13,16-17,20H,3-5,8-9,14H2,1-2H3,(H,27,30)/t16-,20+/m1/s1 GBDWWYIZWHGLEN-UZLBHIALSA-N 320085 3-(5-cyclobutyl- 1,3-thiazol-2-yl)- N-[(1R)-1-(6- methylpyridazin-3- yl)ethyl]-5-[(3S)- tetrahydrofuran-3- yloxy]benzamide::US10174016, Example 252::US10202369, Example 252::US10472354, Example 252 P2X purinoceptor 3 Homo sapiens 75.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320085 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320085&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397825 384223359 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842944 C[C@@H](NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(s1)C1CCC1)c1cnc(C)cn1 InChI=1S/C25H28N4O3S/c1-15-11-27-22(12-26-15)16(2)29-24(30)18-8-19(10-21(9-18)32-20-6-7-31-14-20)25-28-13-23(33-25)17-4-3-5-17/h8-13,16-17,20H,3-7,14H2,1-2H3,(H,29,30)/t16-,20+/m1/s1 FVGXVLFIHFQXPP-UZLBHIALSA-N 320086 3-(5-cyclobutyl- 1,3-thiazol-2-yl)- N-[(1R)-1-(5- methylpyrazin-2- yl)ethyl]-5-[(3S)- tetrahydrofuran-3- yloxy]benzamide::US10174016, Example 253::US10202369, Example 253::US10472354, Example 253 P2X purinoceptor 3 Homo sapiens 99.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320086 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320086&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397513 384223360 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842946 C[C@@H](NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(s1)C1CCC1)c1cnc(nc1)C(F)(F)F InChI=1S/C25H25F3N4O3S/c1-14(18-10-30-24(31-11-18)25(26,27)28)32-22(33)16-7-17(9-20(8-16)35-19-5-6-34-13-19)23-29-12-21(36-23)15-3-2-4-15/h7-12,14-15,19H,2-6,13H2,1H3,(H,32,33)/t14-,19+/m1/s1 IDGMWIXZIVCDCF-KUHUBIRLSA-N 320087 3-(5-cyclobutyl- 1,3-thiazol-2-yl)-5- [(3S)- tetrahydrofuran-3- yloxy]-N-{(1R)-1- [2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 254::US10202369, Example 254::US10472354, Example 254 P2X purinoceptor 3 Homo sapiens 28.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320087 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320087&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397641 384223361 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842948 CC(C)c1cnc(s1)-c1cc(O[C@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1ccc(C)nn1 InChI=1S/C24H28N4O3S/c1-14(2)22-12-25-24(32-22)18-9-17(10-20(11-18)31-19-7-8-30-13-19)23(29)26-16(4)21-6-5-15(3)27-28-21/h5-6,9-12,14,16,19H,7-8,13H2,1-4H3,(H,26,29)/t16-,19+/m1/s1 AZADLHFQZQVHQV-APWZRJJASA-N 320088 N-[(1R)-1-(6- methylpyridazin-3- yl)ethyl]-3-[5- (propan-2-yl)-1,3- thiazol-2-yl]-5- [(3S)- tetrahydrofuran-3- yloxy]benzamide::US10174016, Example 255::US10202369, Example 255::US10472354, Example 255 P2X purinoceptor 3 Homo sapiens 254 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320088 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320088&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397188 384223362 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842950 CC(C)c1cnc(s1)-c1cc(O[C@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1cnc(C)cn1 InChI=1S/C24H28N4O3S/c1-14(2)22-12-27-24(32-22)18-7-17(8-20(9-18)31-19-5-6-30-13-19)23(29)28-16(4)21-11-25-15(3)10-26-21/h7-12,14,16,19H,5-6,13H2,1-4H3,(H,28,29)/t16-,19+/m1/s1 ULUQVVVXKLITBV-APWZRJJASA-N 320089 N-[(1R)-1-(5- methylpyrazin-2- yl)ethyl]-3-[5- (propan-2-yl)-1,3- thiazol-2-yl]-5- [(3S)- tetrahydrofuran-3- yloxy]benzamide::US10174016, Example 256::US10202369, Example 256::US10472354, Example 256 P2X purinoceptor 3 Homo sapiens 136 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320089 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320089&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397239 384223363 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842952 CC(C)c1cnc(s1)-c1cc(O[C@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C24H25F3N4O3S/c1-13(2)20-11-28-22(35-20)16-6-15(7-19(8-16)34-18-4-5-33-12-18)21(32)31-14(3)17-9-29-23(30-10-17)24(25,26)27/h6-11,13-14,18H,4-5,12H2,1-3H3,(H,31,32)/t14-,18+/m1/s1 COCLYUAEQYUAPW-KDOFPFPSSA-N 320090 3-[5-(propan-2-yl)- 1,3-thiazol-2-yl]-5- [(3S)- tetrahydrofuran-3- yloxy]-N-{(1R)-1- [2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 257::US10202369, Example 257::US10472354, Example 257 P2X purinoceptor 3 Homo sapiens 47.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320090 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320090&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397534 384223364 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842954 CCc1cnc(s1)-c1cc(OC[C@@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1ccc(C)nn1 InChI=1S/C24H28N4O3S/c1-4-21-12-25-24(32-21)19-9-18(10-20(11-19)31-14-17-7-8-30-13-17)23(29)26-16(3)22-6-5-15(2)27-28-22/h5-6,9-12,16-17H,4,7-8,13-14H2,1-3H3,(H,26,29)/t16-,17-/m1/s1 CPQUPRVXRIYFHX-IAGOWNOFSA-N 320091 3-(5-ethyl-1,3- thiazol-2-yl)-N- [(1R)-1-(6- methylpyridazin-3- yl)ethyl]-5-[(3R)- tetrahydrofuran-3- ylmethoxy] benzamide::US10174016, Example 258::US10202369, Example 258::US10472354, Example 282 P2X purinoceptor 3 Homo sapiens 4.00 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320091 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320091&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397177 384223365 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842956 CCc1cnc(s1)-c1cc(OC[C@@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1cnc(C)cn1 InChI=1S/C24H28N4O3S/c1-4-21-11-27-24(32-21)19-7-18(8-20(9-19)31-14-17-5-6-30-13-17)23(29)28-16(3)22-12-25-15(2)10-26-22/h7-12,16-17H,4-6,13-14H2,1-3H3,(H,28,29)/t16-,17-/m1/s1 PZFOCXJBZDWRSU-IAGOWNOFSA-N 320092 3-(5-ethyl-1,3- thiazol-2-yl)-N- [(1R)-1-(5- methylpyrazin-2- yl)ethyl]-5-[(3R)- tetrahydrofuran-3- ylmethoxy] benzamide::US10174016, Example 259::US10202369, Example 259::US10472354, Example 283 P2X purinoceptor 3 Homo sapiens 10.00 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320092 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320092&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397564 384223366 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842958 CCc1cnc(s1)-c1cc(OC[C@@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C24H25F3N4O3S/c1-3-20-11-28-22(35-20)17-6-16(7-19(8-17)34-13-15-4-5-33-12-15)21(32)31-14(2)18-9-29-23(30-10-18)24(25,26)27/h6-11,14-15H,3-5,12-13H2,1-2H3,(H,31,32)/t14-,15-/m1/s1 VOKPPDDBRIDGES-HUUCEWRRSA-N 320093 3-(5-ethyl-1,3- thiazol-2-yl)-5- [(3R)- tetrahydrofuran-3- ylmethoxy]-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 260::US10202369, Example 260::US10472354, Example 260 P2X purinoceptor 3 Homo sapiens 2.00 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320093 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320093&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397266 384223367 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842960 C[C@@H](NC(=O)c1cc(OC[C@@H]2CCOC2)cc(c1)-c1ncc(s1)C1CCC1)c1ccc(C)nn1 InChI=1S/C26H30N4O3S/c1-16-6-7-23(30-29-16)17(2)28-25(31)20-10-21(26-27-13-24(34-26)19-4-3-5-19)12-22(11-20)33-15-18-8-9-32-14-18/h6-7,10-13,17-19H,3-5,8-9,14-15H2,1-2H3,(H,28,31)/t17-,18-/m1/s1 KRMAXJMLJAVOGJ-QZTJIDSGSA-N 320094 3-(5-cyclobutyl- 1,3-thiazol-2-yl)- N-[(1R)-1-(6- methylpyridazin-3- yl)ethyl]-5-[(3R)- tetrahydrofuran-3- ylmethoxy] benzamide::US10174016, Example 261::US10202369, Example 261::US10472354, Example 261 P2X purinoceptor 3 Homo sapiens 45.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320094 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320094&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397842 384223368 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842962 C[C@@H](NC(=O)c1cc(OC[C@@H]2CCOC2)cc(c1)-c1ncc(s1)C1CCC1)c1cnc(C)cn1 InChI=1S/C26H30N4O3S/c1-16-11-28-23(12-27-16)17(2)30-25(31)20-8-21(26-29-13-24(34-26)19-4-3-5-19)10-22(9-20)33-15-18-6-7-32-14-18/h8-13,17-19H,3-7,14-15H2,1-2H3,(H,30,31)/t17-,18-/m1/s1 ZBRXLMDGZXDHGV-QZTJIDSGSA-N 320095 3-(5-cyclobutyl- 1,3-thiazol-2-yl)- N-[(1R)-1-(5- methylpyrazin-2- yl)ethyl]-5-[(3R)- tetrahydrofuran-3- ylmethoxy] benzamide::US10174016, Example 262::US10202369, Example 262::US10472354, Example 262 P2X purinoceptor 3 Homo sapiens 85.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320095 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320095&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397383 384223369 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842964 C[C@@H](NC(=O)c1cc(OC[C@@H]2CCOC2)cc(c1)-c1ncc(s1)C1CCC1)c1cnc(nc1)C(F)(F)F InChI=1S/C26H27F3N4O3S/c1-15(20-10-31-25(32-11-20)26(27,28)29)33-23(34)18-7-19(24-30-12-22(37-24)17-3-2-4-17)9-21(8-18)36-14-16-5-6-35-13-16/h7-12,15-17H,2-6,13-14H2,1H3,(H,33,34)/t15-,16-/m1/s1 JWRPHAGJMIAQMD-HZPDHXFCSA-N 320096 3-(5-cyclobutyl- 1,3-thiazol-2-yl)-5- [(3R)- tetrahydrofuran-3- ylmethoxy]-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 263::US10202369, Example 263::US10472354, Example 263 P2X purinoceptor 3 Homo sapiens 33.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320096 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320096&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397122 384223370 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842966 CC(C)c1cnc(s1)-c1cc(OC[C@@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1ccc(C)nn1 InChI=1S/C25H30N4O3S/c1-15(2)23-12-26-25(33-23)20-9-19(10-21(11-20)32-14-18-7-8-31-13-18)24(30)27-17(4)22-6-5-16(3)28-29-22/h5-6,9-12,15,17-18H,7-8,13-14H2,1-4H3,(H,27,30)/t17-,18-/m1/s1 HVLSFPXITWENER-QZTJIDSGSA-N 320097 N-[(1R)-1-(6- methylpyridazin-3- yl)ethyl]-3-[5- (propan-2-yl)-1,3- thiazol-2-yl]-5- [(3R)- tetrahydrofuran-3- ylmethoxy] benzamide::US10174016, Example 264::US10202369, Example 264::US10472354, Example 264 P2X purinoceptor 3 Homo sapiens 81.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320097 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320097&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397620 384223371 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842968 CC(C)c1cnc(s1)-c1cc(OC[C@@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1cnc(C)cn1 InChI=1S/C25H30N4O3S/c1-15(2)23-12-28-25(33-23)20-7-19(8-21(9-20)32-14-18-5-6-31-13-18)24(30)29-17(4)22-11-26-16(3)10-27-22/h7-12,15,17-18H,5-6,13-14H2,1-4H3,(H,29,30)/t17-,18-/m1/s1 MWBSFWZECXCRJX-QZTJIDSGSA-N 320098 N-[(1R)-1-(5- methylpyrazin-2- yl)ethyl]-3-[5- (propan-2-yl)-1,3- thiazol-2-yl]-5- [(3R)- tetrahydrofuran-3- ylmethoxy] benzamide::US10174016, Example 265::US10202369, Example 265::US10472354, Example 265 P2X purinoceptor 3 Homo sapiens 104 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320098 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320098&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397233 384223372 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842970 CC(C)c1cnc(s1)-c1cc(OC[C@@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C25H27F3N4O3S/c1-14(2)21-11-29-23(36-21)18-6-17(7-20(8-18)35-13-16-4-5-34-12-16)22(33)32-15(3)19-9-30-24(31-10-19)25(26,27)28/h6-11,14-16H,4-5,12-13H2,1-3H3,(H,32,33)/t15-,16-/m1/s1 JZRSBKDBMGCFDH-HZPDHXFCSA-N 320099 3-[5-(propan-2-yl)- 1,3-thiazol-2-yl]-5- [(3R)- tetrahydrofuran-3- ylmethoxy]-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 266::US10202369, Example 266::US10472354, Example 266 P2X purinoceptor 3 Homo sapiens 41.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320099 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320099&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397337 384223373 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842972 CCc1cnc(s1)-c1cc(OC[C@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1ccc(C)nn1 InChI=1S/C24H28N4O3S/c1-4-21-12-25-24(32-21)19-9-18(10-20(11-19)31-14-17-7-8-30-13-17)23(29)26-16(3)22-6-5-15(2)27-28-22/h5-6,9-12,16-17H,4,7-8,13-14H2,1-3H3,(H,26,29)/t16-,17+/m1/s1 CPQUPRVXRIYFHX-SJORKVTESA-N 320109 3-(5-ethyl-1,3- thiazol-2-yl)-N- [(1R)-1-(6- methylpyridazin-3- yl)ethyl]-5-[(3S)- tetrahydrofuran-3- ylmethoxy] benzamide::US10174016, Example 276::US10472354, Example 276 P2X purinoceptor 3 Homo sapiens 14.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320109 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320109&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397609 384223383 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842974 CCc1cnc(s1)-c1cc(OC[C@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1cnc(C)cn1 InChI=1S/C24H28N4O3S/c1-4-21-11-27-24(32-21)19-7-18(8-20(9-19)31-14-17-5-6-30-13-17)23(29)28-16(3)22-12-25-15(2)10-26-22/h7-12,16-17H,4-6,13-14H2,1-3H3,(H,28,29)/t16-,17+/m1/s1 PZFOCXJBZDWRSU-SJORKVTESA-N 320110 3-(5-ethyl-1,3- thiazol-2-yl)-N- [(1R)-1-(5- methylpyrazin-2- yl)ethyl]-5-[(3S)- tetrahydrofuran-3- ylmethoxy] benzamide::US10174016, Example 277::US10472354, Example 277 P2X purinoceptor 3 Homo sapiens 14.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320110 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320110&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397468 384223384 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842976 CCc1cnc(s1)-c1cc(OC[C@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C24H25F3N4O3S/c1-3-20-11-28-22(35-20)17-6-16(7-19(8-17)34-13-15-4-5-33-12-15)21(32)31-14(2)18-9-29-23(30-10-18)24(25,26)27/h6-11,14-15H,3-5,12-13H2,1-2H3,(H,31,32)/t14-,15+/m1/s1 VOKPPDDBRIDGES-CABCVRRESA-N 320111 3-(5-ethyl-1,3- thiazol-2-yl)-5- [(3S)- tetrahydrofuran-3- ylmethoxy]-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 278::US10472354, Example 278 P2X purinoceptor 3 Homo sapiens 2.00 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320111 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320111&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397387 384223385 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842978 C[C@@H](NC(=O)c1cc(OC[C@H]2CCOC2)cc(c1)-c1ncc(s1)C1CCC1)c1ccc(C)nn1 InChI=1S/C26H30N4O3S/c1-16-6-7-23(30-29-16)17(2)28-25(31)20-10-21(26-27-13-24(34-26)19-4-3-5-19)12-22(11-20)33-15-18-8-9-32-14-18/h6-7,10-13,17-19H,3-5,8-9,14-15H2,1-2H3,(H,28,31)/t17-,18+/m1/s1 KRMAXJMLJAVOGJ-MSOLQXFVSA-N 319968 3-(5-Cyclobutyl-1,3-thiazol-2-yl)-N-[(1R)-1-(6-methylpyridazin-3-yl)ethyl]-5-[(3S)-tetrahydrofuran-3-ylmethoxy]benzamide::US10174016, Example 135::US10202369, Example 135::US10472354, Example 270 P2X purinoceptor 3 Homo sapiens 25.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319968 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319968&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397422 384223248 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842980 C[C@@H](NC(=O)c1cc(OC[C@H]2CCOC2)cc(c1)-c1ncc(s1)C1CCC1)c1cnc(C)cn1 InChI=1S/C26H30N4O3S/c1-16-11-28-23(12-27-16)17(2)30-25(31)20-8-21(26-29-13-24(34-26)19-4-3-5-19)10-22(9-20)33-15-18-6-7-32-14-18/h8-13,17-19H,3-7,14-15H2,1-2H3,(H,30,31)/t17-,18+/m1/s1 ZBRXLMDGZXDHGV-MSOLQXFVSA-N 319954 3-(5-Cyclobutyl-1,3-thiazol-2-yl)-N-[(1R)-1-(5-methylpyrazin-2-yl)ethyl]-5-[(3S)-tetrahydrofuran-3-ylmethoxy]benzamide::US10174016, Example 121::US10202369, Example 121::US10472354, Example 271 P2X purinoceptor 3 Homo sapiens 45.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319954 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319954&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397486 384223234 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842982 C[C@@H](NC(=O)c1cc(OC[C@H]2CCOC2)cc(c1)-c1ncc(s1)C1CCC1)c1cnc(nc1)C(F)(F)F InChI=1S/C26H27F3N4O3S/c1-15(20-10-31-25(32-11-20)26(27,28)29)33-23(34)18-7-19(24-30-12-22(37-24)17-3-2-4-17)9-21(8-18)36-14-16-5-6-35-13-16/h7-12,15-17H,2-6,13-14H2,1H3,(H,33,34)/t15-,16+/m1/s1 JWRPHAGJMIAQMD-CVEARBPZSA-N 319956 3-(5-Cyclobutyl-1,3-thiazol-2-yl)-5-[(3S)-tetrahydrofuran-3-ylmethoxy]-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 123::US10202369, Example 123::US10472354, Example 272 P2X purinoceptor 3 Homo sapiens 19.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319956 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319956&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397161 384223236 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842984 CC(C)c1cnc(s1)-c1cc(OC[C@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1ccc(C)nn1 InChI=1S/C25H30N4O3S/c1-15(2)23-12-26-25(33-23)20-9-19(10-21(11-20)32-14-18-7-8-31-13-18)24(30)27-17(4)22-6-5-16(3)28-29-22/h5-6,9-12,15,17-18H,7-8,13-14H2,1-4H3,(H,27,30)/t17-,18+/m1/s1 HVLSFPXITWENER-MSOLQXFVSA-N 320112 N-[(1R)-1-(6- methylpyridazin-3- yl)ethyl]-3-[5- (propan-2-yl)-1,3- thiazol-2-yl]-5- [(3S)- tetrahydrofuran-3- ylmethoxy] benzamide::US10174016, Example 279::US10472354, Example 279 P2X purinoceptor 3 Homo sapiens 28.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320112 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320112&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397672 384223386 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842986 CC(C)c1cnc(s1)-c1cc(OC[C@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1cnc(C)cn1 InChI=1S/C25H30N4O3S/c1-15(2)23-12-28-25(33-23)20-7-19(8-21(9-20)32-14-18-5-6-31-13-18)24(30)29-17(4)22-11-26-16(3)10-27-22/h7-12,15,17-18H,5-6,13-14H2,1-4H3,(H,29,30)/t17-,18+/m1/s1 MWBSFWZECXCRJX-MSOLQXFVSA-N 320113 N-[(1R)-1-(5- methylpyrazin-2- yl)ethyl]-3-[5- (propan-2-yl)-1,3- thiazol-2-yl]-5- [(3S)- tetrahydrofuran-3- ylmethoxy] benzamide::US10174016, Example 280::US10472354, Example 280 P2X purinoceptor 3 Homo sapiens 75.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320113 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320113&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397160 384223387 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842988 CC(C)c1cnc(s1)-c1cc(OC[C@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C25H27F3N4O3S/c1-14(2)21-11-29-23(36-21)18-6-17(7-20(8-18)35-13-16-4-5-34-12-16)22(33)32-15(3)19-9-30-24(31-10-19)25(26,27)28/h6-11,14-16H,4-5,12-13H2,1-3H3,(H,32,33)/t15-,16+/m1/s1 JZRSBKDBMGCFDH-CVEARBPZSA-N 320114 3-[5-(propan-2-yl)- 1,3-thiazol-2-yl]-5- [(3S)- tetrahydrofuran-3- ylmethoxy]-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 281::US10472354, Example 281 P2X purinoceptor 3 Homo sapiens 21.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320114 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320114&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397335 384223388 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842990 CCc1cnc(s1)-c1cc(OC[C@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1ccc(C)nn1 InChI=1S/C24H28N4O3S/c1-4-21-12-25-24(32-21)19-9-18(10-20(11-19)31-14-17-7-8-30-13-17)23(29)26-16(3)22-6-5-15(2)27-28-22/h5-6,9-12,16-17H,4,7-8,13-14H2,1-3H3,(H,26,29)/t16-,17+/m1/s1 CPQUPRVXRIYFHX-SJORKVTESA-N 320109 3-(5-ethyl-1,3- thiazol-2-yl)-N- [(1R)-1-(6- methylpyridazin-3- yl)ethyl]-5-[(3S)- tetrahydrofuran-3- ylmethoxy] benzamide::US10174016, Example 276::US10472354, Example 276 P2X purinoceptor 3 Homo sapiens 10.00 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320109 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320109&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397609 384223383 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842992 CCc1cnc(s1)-c1cc(OC[C@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1cnc(C)cn1 InChI=1S/C24H28N4O3S/c1-4-21-11-27-24(32-21)19-7-18(8-20(9-19)31-14-17-5-6-30-13-17)23(29)28-16(3)22-12-25-15(2)10-26-22/h7-12,16-17H,4-6,13-14H2,1-3H3,(H,28,29)/t16-,17+/m1/s1 PZFOCXJBZDWRSU-SJORKVTESA-N 320110 3-(5-ethyl-1,3- thiazol-2-yl)-N- [(1R)-1-(5- methylpyrazin-2- yl)ethyl]-5-[(3S)- tetrahydrofuran-3- ylmethoxy] benzamide::US10174016, Example 277::US10472354, Example 277 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320110 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320110&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397468 384223384 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842994 CCc1cnc(s1)-c1cc(OC[C@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C24H25F3N4O3S/c1-3-20-11-28-22(35-20)17-6-16(7-19(8-17)34-13-15-4-5-33-12-15)21(32)31-14(2)18-9-29-23(30-10-18)24(25,26)27/h6-11,14-15H,3-5,12-13H2,1-2H3,(H,31,32)/t14-,15+/m1/s1 VOKPPDDBRIDGES-CABCVRRESA-N 320111 3-(5-ethyl-1,3- thiazol-2-yl)-5- [(3S)- tetrahydrofuran-3- ylmethoxy]-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 278::US10472354, Example 278 P2X purinoceptor 3 Homo sapiens 2.00 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320111 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320111&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397387 384223385 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842996 CC(C)c1cnc(s1)-c1cc(OC[C@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1ccc(C)nn1 InChI=1S/C25H30N4O3S/c1-15(2)23-12-26-25(33-23)20-9-19(10-21(11-20)32-14-18-7-8-31-13-18)24(30)27-17(4)22-6-5-16(3)28-29-22/h5-6,9-12,15,17-18H,7-8,13-14H2,1-4H3,(H,27,30)/t17-,18+/m1/s1 HVLSFPXITWENER-MSOLQXFVSA-N 320112 N-[(1R)-1-(6- methylpyridazin-3- yl)ethyl]-3-[5- (propan-2-yl)-1,3- thiazol-2-yl]-5- [(3S)- tetrahydrofuran-3- ylmethoxy] benzamide::US10174016, Example 279::US10472354, Example 279 P2X purinoceptor 3 Homo sapiens 115 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320112 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320112&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397672 384223386 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 842998 CC(C)c1cnc(s1)-c1cc(OC[C@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1cnc(C)cn1 InChI=1S/C25H30N4O3S/c1-15(2)23-12-28-25(33-23)20-7-19(8-21(9-20)32-14-18-5-6-31-13-18)24(30)29-17(4)22-11-26-16(3)10-27-22/h7-12,15,17-18H,5-6,13-14H2,1-4H3,(H,29,30)/t17-,18+/m1/s1 MWBSFWZECXCRJX-MSOLQXFVSA-N 320113 N-[(1R)-1-(5- methylpyrazin-2- yl)ethyl]-3-[5- (propan-2-yl)-1,3- thiazol-2-yl]-5- [(3S)- tetrahydrofuran-3- ylmethoxy] benzamide::US10174016, Example 280::US10472354, Example 280 P2X purinoceptor 3 Homo sapiens 51.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320113 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320113&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397160 384223387 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843000 CC(C)c1cnc(s1)-c1cc(OC[C@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C25H27F3N4O3S/c1-14(2)21-11-29-23(36-21)18-6-17(7-20(8-18)35-13-16-4-5-34-12-16)22(33)32-15(3)19-9-30-24(31-10-19)25(26,27)28/h6-11,14-16H,4-5,12-13H2,1-3H3,(H,32,33)/t15-,16+/m1/s1 JZRSBKDBMGCFDH-CVEARBPZSA-N 320114 3-[5-(propan-2-yl)- 1,3-thiazol-2-yl]-5- [(3S)- tetrahydrofuran-3- ylmethoxy]-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 281::US10472354, Example 281 P2X purinoceptor 3 Homo sapiens 26.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320114 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320114&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397335 384223388 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843002 CCc1cnc(s1)-c1cc(OC[C@@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1ccc(C)nn1 InChI=1S/C24H28N4O3S/c1-4-21-12-25-24(32-21)19-9-18(10-20(11-19)31-14-17-7-8-30-13-17)23(29)26-16(3)22-6-5-15(2)27-28-22/h5-6,9-12,16-17H,4,7-8,13-14H2,1-3H3,(H,26,29)/t16-,17-/m1/s1 CPQUPRVXRIYFHX-IAGOWNOFSA-N 320091 3-(5-ethyl-1,3- thiazol-2-yl)-N- [(1R)-1-(6- methylpyridazin-3- yl)ethyl]-5-[(3R)- tetrahydrofuran-3- ylmethoxy] benzamide::US10174016, Example 258::US10202369, Example 258::US10472354, Example 282 P2X purinoceptor 3 Homo sapiens 8.00 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320091 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320091&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397177 384223365 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843004 CCc1cnc(s1)-c1cc(OC[C@@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1cnc(C)cn1 InChI=1S/C24H28N4O3S/c1-4-21-11-27-24(32-21)19-7-18(8-20(9-19)31-14-17-5-6-30-13-17)23(29)28-16(3)22-12-25-15(2)10-26-22/h7-12,16-17H,4-6,13-14H2,1-3H3,(H,28,29)/t16-,17-/m1/s1 PZFOCXJBZDWRSU-IAGOWNOFSA-N 320092 3-(5-ethyl-1,3- thiazol-2-yl)-N- [(1R)-1-(5- methylpyrazin-2- yl)ethyl]-5-[(3R)- tetrahydrofuran-3- ylmethoxy] benzamide::US10174016, Example 259::US10202369, Example 259::US10472354, Example 283 P2X purinoceptor 3 Homo sapiens 10.00 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320092 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320092&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397564 384223366 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843006 CCc1cnc(s1)-c1cc(OC[C@@H]2CCCO2)cc(c1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C24H25F3N4O3S/c1-3-20-12-28-22(35-20)16-7-15(8-19(9-16)34-13-18-5-4-6-33-18)21(32)31-14(2)17-10-29-23(30-11-17)24(25,26)27/h7-12,14,18H,3-6,13H2,1-2H3,(H,31,32)/t14-,18+/m1/s1 IDFXYIYQWCENGA-KDOFPFPSSA-N 320117 3-(5-ethyl-1,3- thiazol-2-yl)-5- [(2S)- tetrahydrofuran-2- ylmethoxy]-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 284::US10202369, Example 284::US10472354, Example 284 P2X purinoceptor 3 Homo sapiens 4.00 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320117 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320117&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397623 384223391 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843008 C[C@@H](NC(=O)c1cc(OC[C@@H]2CCCO2)cc(c1)-c1ncc(s1)C1CCC1)c1ccc(C)nn1 InChI=1S/C26H30N4O3S/c1-16-8-9-23(30-29-16)17(2)28-25(31)19-11-20(26-27-14-24(34-26)18-5-3-6-18)13-22(12-19)33-15-21-7-4-10-32-21/h8-9,11-14,17-18,21H,3-7,10,15H2,1-2H3,(H,28,31)/t17-,21+/m1/s1 NLLVDMMXBRFWGS-UTKZUKDTSA-N 320118 3-(5-cyclobutyl- 1,3-thiazol-2-yl)- N-[(1R)-1-(6- methylpyridazin-3- yl)ethyl]-5-[(2S)- tetrahydrofuran-2- ylmethoxy] benzamide::US10174016, Example 285::US10202369, Example 285::US10472354, Example 285 P2X purinoceptor 3 Homo sapiens 113 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320118 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320118&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397163 384223392 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843010 C[C@@H](NC(=O)c1cc(OC[C@@H]2CCCO2)cc(c1)-c1ncc(s1)C1CCC1)c1cnc(C)cn1 InChI=1S/C26H30N4O3S/c1-16-12-28-23(13-27-16)17(2)30-25(31)19-9-20(26-29-14-24(34-26)18-5-3-6-18)11-22(10-19)33-15-21-7-4-8-32-21/h9-14,17-18,21H,3-8,15H2,1-2H3,(H,30,31)/t17-,21+/m1/s1 BHRXSWOPMLFOCG-UTKZUKDTSA-N 320119 3-(5-cyclobutyl- 1,3-thiazol-2-yl)- N-[(1R)-1-(5- methylpyrazin-2- yl)ethyl]-5-[(2S)- tetrahydrofuran-2- ylmethoxy]benzamide::US10174016, Example 286::US10202369, Example 286::US10472354, Example 286 P2X purinoceptor 3 Homo sapiens 87.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320119 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320119&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397754 384223393 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843012 C[C@@H](NC(=O)c1cc(OC[C@@H]2CCCO2)cc(c1)-c1ncc(s1)C1CCC1)c1cnc(nc1)C(F)(F)F InChI=1S/C26H27F3N4O3S/c1-15(19-11-31-25(32-12-19)26(27,28)29)33-23(34)17-8-18(24-30-13-22(37-24)16-4-2-5-16)10-21(9-17)36-14-20-6-3-7-35-20/h8-13,15-16,20H,2-7,14H2,1H3,(H,33,34)/t15-,20+/m1/s1 ZERBIURYMMOJBU-QRWLVFNGSA-N 320120 3-(5-cyclobutyl- 1,3-thiazol-2-yl)-5- [(2S)- tetrahydrofuran-2- ylmethoxy]-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 287::US10202369, Example 287::US10472354, Example 287 P2X purinoceptor 3 Homo sapiens 35.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320120 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320120&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397159 384223394 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843014 CC(C)c1cnc(s1)-c1cc(OC[C@@H]2CCCO2)cc(c1)C(=O)N[C@H](C)c1ccc(C)nn1 InChI=1S/C25H30N4O3S/c1-15(2)23-13-26-25(33-23)19-10-18(11-21(12-19)32-14-20-6-5-9-31-20)24(30)27-17(4)22-8-7-16(3)28-29-22/h7-8,10-13,15,17,20H,5-6,9,14H2,1-4H3,(H,27,30)/t17-,20+/m1/s1 UAMKMSQRQBQFJK-XLIONFOSSA-N 320121 N-[(1R)-1-(6- methylpyridazin-3- yl)ethyl]-3-[5- (propan-2-yl)-1,3- thiazol-2-yl]-5- [(2S)- tetrahydrofuran-2- ylmethoxy] benzamide::US10174016, Example 288::US10202369, Example 288::US10472354, Example 288 P2X purinoceptor 3 Homo sapiens 150 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320121 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320121&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397738 384223395 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843016 CC(C)c1cnc(s1)-c1cc(OC[C@@H]2CCCO2)cc(c1)C(=O)N[C@H](C)c1cnc(C)cn1 InChI=1S/C25H30N4O3S/c1-15(2)23-13-28-25(33-23)19-8-18(9-21(10-19)32-14-20-6-5-7-31-20)24(30)29-17(4)22-12-26-16(3)11-27-22/h8-13,15,17,20H,5-7,14H2,1-4H3,(H,29,30)/t17-,20+/m1/s1 CNKRLRNKYMMPAE-XLIONFOSSA-N 320122 N-[(1R)-1-(5- methylpyrazin-2- yl)ethyl]-3-[5- (propan-2-yl)-1,3- thiazol-2-yl]-5- [(2S)- tetrahydrofuran-2- ylmethoxy]benzamide::US10174016, Example 289::US10202369, Example 289::US10472354, Example 289 P2X purinoceptor 3 Homo sapiens 192 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320122 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320122&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397419 384223396 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843018 CC(C)c1cnc(s1)-c1cc(OC[C@@H]2CCCO2)cc(c1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C25H27F3N4O3S/c1-14(2)21-12-29-23(36-21)17-7-16(8-20(9-17)35-13-19-5-4-6-34-19)22(33)32-15(3)18-10-30-24(31-11-18)25(26,27)28/h7-12,14-15,19H,4-6,13H2,1-3H3,(H,32,33)/t15-,19+/m1/s1 KTCCKJLURHRITN-BEFAXECRSA-N 320123 3-[5-(propan-2-yl)- 1,3-thiazol-2-yl]-5- [(2S)- tetrahydrofuran-2- ylmethoxy]-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 290::US10472354, Example 290 P2X purinoceptor 3 Homo sapiens 31.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320123 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320123&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397222 384223397 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843020 C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C22H21F3N4O3S/c1-12-8-26-20(33-12)15-5-14(6-18(7-15)32-17-3-4-31-11-17)19(30)29-13(2)16-9-27-21(28-10-16)22(23,24)25/h5-10,13,17H,3-4,11H2,1-2H3,(H,29,30)/t13-,17-/m1/s1 GTQPEQGDLVSFJO-CXAGYDPISA-N 319844 3-(5-Methyl-1,3-thiazol-2-yl)-5-[(3R)-tetrahydrofuran-3-yloxy]-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 11::US10202369, Example 11::US10472354, Example 291 P2X purinoceptor 3 Homo sapiens 1320 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319844 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319844&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397587 384223124 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843022 CCc1cnc(s1)-c1cc(OC[C@@H]2CCCO2)cc(c1)C(=O)N[C@H](C)c1ccc(nn1)C(F)(F)F InChI=1S/C24H25F3N4O3S/c1-3-19-12-28-23(35-19)16-9-15(10-18(11-16)34-13-17-5-4-8-33-17)22(32)29-14(2)20-6-7-21(31-30-20)24(25,26)27/h6-7,9-12,14,17H,3-5,8,13H2,1-2H3,(H,29,32)/t14-,17+/m1/s1 JBKILHBMFZDIIA-PBHICJAKSA-N 320135 3-(5-ethyl-1,3- thiazol-2-yl)-5- [(2S)- tetrahydrofuran-2- ylmethoxy]-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl}benzamide::US10174016, Example 302::US10202369, Example 302::US10472354, Example 302 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320135 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320135&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397753 384223409 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843024 CC(C)c1cnc(s1)-c1cc(OC[C@@H]2CCCO2)cc(c1)C(=O)N[C@H](C)c1ccc(nn1)C(F)(F)F InChI=1S/C25H27F3N4O3S/c1-14(2)21-12-29-24(36-21)17-9-16(10-19(11-17)35-13-18-5-4-8-34-18)23(33)30-15(3)20-6-7-22(32-31-20)25(26,27)28/h6-7,9-12,14-15,18H,4-5,8,13H2,1-3H3,(H,30,33)/t15-,18+/m1/s1 QOJBRGRPZKZVKC-QAPCUYQASA-N 320134 3-[5-(propan-2-yl)- 1,3-thiazol-2-yl]-5- [(2S)- tetrahydrofuran-2- ylmethoxy]-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl}benzamide::US10174016, Example 301::US10472354, Example 301 P2X purinoceptor 3 Homo sapiens 63.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320134 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320134&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397464 384223408 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843026 CC(C)c1cnc(s1)-c1cc(O[C@@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1ccc(nn1)C(F)(F)F InChI=1S/C24H25F3N4O3S/c1-13(2)20-11-28-23(35-20)16-8-15(9-18(10-16)34-17-6-7-33-12-17)22(32)29-14(3)19-4-5-21(31-30-19)24(25,26)27/h4-5,8-11,13-14,17H,6-7,12H2,1-3H3,(H,29,32)/t14-,17-/m1/s1 ALCUBFBGIYQDIY-RHSMWYFYSA-N 320127 3-[5-(propan-2-yl)- 1,3-thiazol-2-yl]-5- [(3R)- tetrahydrofuran-3- yloxy]-N-{(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl}benzamide::US10174016, Example 294::US10202369, Example 294::US10472354, Example 294 P2X purinoceptor 3 Homo sapiens 101 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320127 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320127&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397844 384223401 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843028 C[C@@H](NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(s1)C1CCC1)c1ccc(nn1)C(F)(F)F InChI=1S/C25H25F3N4O3S/c1-14(20-5-6-22(32-31-20)25(26,27)28)30-23(33)16-9-17(11-19(10-16)35-18-7-8-34-13-18)24-29-12-21(36-24)15-3-2-4-15/h5-6,9-12,14-15,18H,2-4,7-8,13H2,1H3,(H,30,33)/t14-,18+/m1/s1 LCHSLMNVJPMESH-KDOFPFPSSA-N 320128 3-(5-cyclobutyl- 1,3-thiazol-2-yl)-5- [(3S)- tetrahydrofuran-3- yloxy]-N-{(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl}benzamide::US10174016, Example 295::US10202369, Example 295::US10472354, Example 295 P2X purinoceptor 3 Homo sapiens 55.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320128 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320128&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397441 384223402 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843030 CCc1cnc(s1)-c1cc(OC[C@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1ccc(nn1)C(F)(F)F InChI=1S/C24H25F3N4O3S/c1-3-19-11-28-23(35-19)17-8-16(9-18(10-17)34-13-15-6-7-33-12-15)22(32)29-14(2)20-4-5-21(31-30-20)24(25,26)27/h4-5,8-11,14-15H,3,6-7,12-13H2,1-2H3,(H,29,32)/t14-,15+/m1/s1 PGRAVNCJCWWOPT-CABCVRRESA-N 320129 3-(5-ethyl-1,3- thiazol-2-yl)-5- [(3S)- tetrahydrofuran-3- ylmethoxy]-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl}benzamide::US10174016, Example 296::US10202369, Example 296::US10472354, Example 296 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320129 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320129&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397487 384223403 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843032 C[C@@H](NC(=O)c1cc(OC[C@@H]2CCOC2)cc(c1)-c1ncc(s1)C1CCC1)c1ccc(nn1)C(F)(F)F InChI=1S/C26H27F3N4O3S/c1-15(21-5-6-23(33-32-21)26(27,28)29)31-24(34)18-9-19(25-30-12-22(37-25)17-3-2-4-17)11-20(10-18)36-14-16-7-8-35-13-16/h5-6,9-12,15-17H,2-4,7-8,13-14H2,1H3,(H,31,34)/t15-,16-/m1/s1 BURFLVDKSSJHQL-HZPDHXFCSA-N 320130 3-(5-cyclobutyl- 1,3-thiazol-2-yl)-5- [(3R)- tetrahydrofuran-3- ylmethoxy]-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl}benzamide::US10174016, Example 297::US10202369, Example 300::US10472354, Example 297 P2X purinoceptor 3 Homo sapiens 56.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320130 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320130&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397174 384223404 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843034 CC(C)c1cnc(s1)-c1cc(OC[C@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1ccc(nn1)C(F)(F)F InChI=1S/C25H27F3N4O3S/c1-14(2)21-11-29-24(36-21)18-8-17(9-19(10-18)35-13-16-6-7-34-12-16)23(33)30-15(3)20-4-5-22(32-31-20)25(26,27)28/h4-5,8-11,14-16H,6-7,12-13H2,1-3H3,(H,30,33)/t15-,16+/m1/s1 ZWFOSAQPAKMJAC-CVEARBPZSA-N 320131 3-[5-(propan-2-yl)- 1,3-thiazol-2-yl]-5- [(3S)- tetrahydrofuran-3- ylmethoxy]-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl}benzamide::US10174016, Example 298::US10202369, Example 299::US10472354, Example 298 P2X purinoceptor 3 Homo sapiens 62.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320131 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320131&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397407 384223405 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843036 CC(C)c1cnc(s1)-c1cc(OC[C@H]2CCCO2)cc(c1)C(=O)N[C@H](C)c1ccc(nn1)C(F)(F)F InChI=1S/C25H27F3N4O3S/c1-14(2)21-12-29-24(36-21)17-9-16(10-19(11-17)35-13-18-5-4-8-34-18)23(33)30-15(3)20-6-7-22(32-31-20)25(26,27)28/h6-7,9-12,14-15,18H,4-5,8,13H2,1-3H3,(H,30,33)/t15-,18-/m1/s1 QOJBRGRPZKZVKC-CRAIPNDOSA-N 320132 3-[5-(propan-2-yl)- 1,3-thiazol-2-yl]-5- [(2R)- tetrahydrofuran-2- ylmethoxy]-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl}benzamide::US10174016, Example 299::US10472354, Example 299 P2X purinoceptor 3 Homo sapiens 37.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320132 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320132&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397251 384223406 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843038 C[C@@H](NC(=O)c1cc(OC[C@@H]2CCCO2)cc(c1)-c1ncc(s1)C1CCC1)c1ccc(nn1)C(F)(F)F InChI=1S/C26H27F3N4O3S/c1-15(21-7-8-23(33-32-21)26(27,28)29)31-24(34)17-10-18(25-30-13-22(37-25)16-4-2-5-16)12-20(11-17)36-14-19-6-3-9-35-19/h7-8,10-13,15-16,19H,2-6,9,14H2,1H3,(H,31,34)/t15-,19+/m1/s1 BFQOMUOMPPUOAS-BEFAXECRSA-N 320133 3-(5-cyclobutyl- 1,3-thiazol-2-yl)-5- [(2S)- tetrahydrofuran-2- ylmethoxy]-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl}benzamide::US10174016, Example 300::US10472354, Example 300 P2X purinoceptor 3 Homo sapiens 78.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320133 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320133&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397755 384223407 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843040 CC(C)c1cnc(s1)-c1cc(OC[C@@H]2CCCO2)cc(c1)C(=O)N[C@H](C)c1ccc(nn1)C(F)(F)F InChI=1S/C25H27F3N4O3S/c1-14(2)21-12-29-24(36-21)17-9-16(10-19(11-17)35-13-18-5-4-8-34-18)23(33)30-15(3)20-6-7-22(32-31-20)25(26,27)28/h6-7,9-12,14-15,18H,4-5,8,13H2,1-3H3,(H,30,33)/t15-,18+/m1/s1 QOJBRGRPZKZVKC-QAPCUYQASA-N 320134 3-[5-(propan-2-yl)- 1,3-thiazol-2-yl]-5- [(2S)- tetrahydrofuran-2- ylmethoxy]-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl}benzamide::US10174016, Example 301::US10472354, Example 301 P2X purinoceptor 3 Homo sapiens 91.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320134 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320134&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397464 384223408 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843042 CCc1cnc(s1)-c1cc(OC[C@@H]2CCCO2)cc(c1)C(=O)N[C@H](C)c1ccc(nn1)C(F)(F)F InChI=1S/C24H25F3N4O3S/c1-3-19-12-28-23(35-19)16-9-15(10-18(11-16)34-13-17-5-4-8-33-17)22(32)29-14(2)20-6-7-21(31-30-20)24(25,26)27/h6-7,9-12,14,17H,3-5,8,13H2,1-2H3,(H,29,32)/t14-,17+/m1/s1 JBKILHBMFZDIIA-PBHICJAKSA-N 320135 3-(5-ethyl-1,3- thiazol-2-yl)-5- [(2S)- tetrahydrofuran-2- ylmethoxy]-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl}benzamide::US10174016, Example 302::US10202369, Example 302::US10472354, Example 302 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320135 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320135&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397753 384223409 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843044 C[C@@H](NC(=O)c1cc(OC2CCN(CC(F)(F)F)CC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C25H25F6N5O2S/c1-14-10-32-22(39-14)17-7-16(21(37)35-15(2)18-11-33-23(34-12-18)25(29,30)31)8-20(9-17)38-19-3-5-36(6-4-19)13-24(26,27)28/h7-12,15,19H,3-6,13H2,1-2H3,(H,35,37)/t15-/m1/s1 HEBACSHOFHMYBR-OAHLLOKOSA-N 320136 3-(5-methyl-1,3- thiazol-2-yl)-5-{[1- (2,2,2- trifluoroethyl) piperidin-4-yl]oxy}- N-{(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 303::US10202369, Example 310::US10472354, Example 303 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320136 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320136&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397490 384223410 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843046 C[C@@H](NC(=O)c1cc(OC2CCN(CC(F)F)CC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C25H26F5N5O2S/c1-14-10-31-23(38-14)17-7-16(8-20(9-17)37-19-3-5-35(6-4-19)13-21(26)27)22(36)34-15(2)18-11-32-24(33-12-18)25(28,29)30/h7-12,15,19,21H,3-6,13H2,1-2H3,(H,34,36)/t15-/m1/s1 LOLIYPRJHUXCPO-OAHLLOKOSA-N 320137 3-{[1-(2,2- difluoroethyl) piperidin-4-yl]oxy}- 5-(5-methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoroethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 304::US10202369, Example 308::US10472354, Example 304 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320137 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320137&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397386 384223411 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843048 C[C@@H](NC(=O)c1cc(OC2CCN(CC(F)F)CC2)cc(c1)-c1ncc(C)s1)c1ccc(C)nn1 InChI=1S/C25H29F2N5O2S/c1-15-4-5-22(31-30-15)17(3)29-24(33)18-10-19(25-28-13-16(2)35-25)12-21(11-18)34-20-6-8-32(9-7-20)14-23(26)27/h4-5,10-13,17,20,23H,6-9,14H2,1-3H3,(H,29,33)/t17-/m1/s1 BZVNHOBJGKGQCM-QGZVFWFLSA-N 320138 3-{[1-(2,2- difluoroethyl) piperidin-4-yl]oxy}-N- [(1R)-1-(6- methylpyridazin-3- yl)ethyl]-5-(5- methyl-1,3- thiazol-2-yl) benzamide::US10174016, Example 305::US10202369, Example 305::US10472354, Example 305 P2X purinoceptor 3 Homo sapiens 9.00 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320138 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320138&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397226 384223412 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843050 C[C@@H](NC(=O)c1cc(OC2CCN(CC(F)F)CC2)cc(c1)-c1ncc(C)s1)c1cnc(C)cn1 InChI=1S/C25H29F2N5O2S/c1-15-11-29-22(13-28-15)17(3)31-24(33)18-8-19(25-30-12-16(2)35-25)10-21(9-18)34-20-4-6-32(7-5-20)14-23(26)27/h8-13,17,20,23H,4-7,14H2,1-3H3,(H,31,33)/t17-/m1/s1 OVUBAZICSOPILB-QGZVFWFLSA-N 320139 3-{[1-(2,2- difluoroethyl) piperidin-4-yl]oxy}-N- [(1R)-1-(5- methylpyrazin-2- yl)ethyl]-5-(5- methyl-1,3- thiazol-2-yl) benzamide::US10174016, Example 306::US10202369, Example 306::US10472354, Example 306 P2X purinoceptor 3 Homo sapiens 42.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320139 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320139&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397132 384223413 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843052 Cc1cnc(s1)-c1cc(OC2CCN(CC(F)F)CC2)cc(c1)C(=O)NCc1ccc(C)nn1 InChI=1S/C24H27F2N5O2S/c1-15-3-4-19(30-29-15)13-27-23(32)17-9-18(24-28-12-16(2)34-24)11-21(10-17)33-20-5-7-31(8-6-20)14-22(25)26/h3-4,9-12,20,22H,5-8,13-14H2,1-2H3,(H,27,32) AGOFJROZQVOSRF-UHFFFAOYSA-N 320140 3-{[1-(2,2- difluoroethyl)piperidin- 4-yl]oxy}-N- [(6-methylpyridazin- 3-yl)methyl]-5-(5- methyl-1,3-thiazol-2- yl)benzamide::US10174016, Example 307::US10202369, Example 307::US10472354, Example 307 P2X purinoceptor 3 Homo sapiens 16.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320140 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320140&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397369 384223414 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843054 C[C@H](NC(=O)c1cc(OC2CCN(CC(F)F)CC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C25H26F5N5O2S/c1-14-10-31-23(38-14)17-7-16(8-20(9-17)37-19-3-5-35(6-4-19)13-21(26)27)22(36)34-15(2)18-11-32-24(33-12-18)25(28,29)30/h7-12,15,19,21H,3-6,13H2,1-2H3,(H,34,36)/t15-/m0/s1 LOLIYPRJHUXCPO-HNNXBMFYSA-N 320141 3-{[1-(2,2- difluoroethyl)piperidin- 4-yl]oxy}-5-(5- methyl-1,3-thiazol-2- yl)-N- {(1S)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 308::US10472354, Example 308 P2X purinoceptor 3 Homo sapiens 153 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320141 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320141&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397709 384223415 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843056 C[C@@H](NC(=O)c1cc(OC2CCN(CC(F)F)CC2)cc(c1)-c1ncc(C)s1)c1cnc(C)nc1 InChI=1S/C25H29F2N5O2S/c1-15-11-30-25(35-15)19-8-18(24(33)31-16(2)20-12-28-17(3)29-13-20)9-22(10-19)34-21-4-6-32(7-5-21)14-23(26)27/h8-13,16,21,23H,4-7,14H2,1-3H3,(H,31,33)/t16-/m1/s1 XIVLMPYTLPVWPV-MRXNPFEDSA-N 320142 3-{[1-(2,2- difluoroethyl)piperidin- 4-yl]oxy}-N- [(1R)-1-(2- methylpyrimidin- 5-yl)ethyl]-5-(5- methyl-1,3-thiazol-2- yl)benzamide::US10174016, Example 309::US10202369, Example 309::US10472354, Example 309 P2X purinoceptor 3 Homo sapiens 8.00 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320142 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320142&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397638 384223416 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843058 C[C@H](NC(=O)c1cc(OC2CCN(CC(F)(F)F)CC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C25H25F6N5O2S/c1-14-10-32-22(39-14)17-7-16(21(37)35-15(2)18-11-33-23(34-12-18)25(29,30)31)8-20(9-17)38-19-3-5-36(6-4-19)13-24(26,27)28/h7-12,15,19H,3-6,13H2,1-2H3,(H,35,37)/t15-/m0/s1 HEBACSHOFHMYBR-HNNXBMFYSA-N 320143 3-(5-methyl-1,3- thiazol-2-yl)-5-{[1- (2,2,2- trifluoroethyl) piperidin-4-yl]oxy}-N- {(1S)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 310::US10472354, Example 310 P2X purinoceptor 3 Homo sapiens 116 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320143 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320143&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397431 384223417 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843060 C[C@@H](NC(=O)c1cc(OC2CCN(CC(F)(F)F)CC2)cc(c1)-c1ncc(C)s1)c1ccc(C)nn1 InChI=1S/C25H28F3N5O2S/c1-15-4-5-22(32-31-15)17(3)30-23(34)18-10-19(24-29-13-16(2)36-24)12-21(11-18)35-20-6-8-33(9-7-20)14-25(26,27)28/h4-5,10-13,17,20H,6-9,14H2,1-3H3,(H,30,34)/t17-/m1/s1 PEAPNGOBIXQGEJ-QGZVFWFLSA-N 320144 N-[(1R)-1-(6- methylpyridazin-3- yl)ethyl]-3-(5- methyl-1,3- thiazol-2-yl)-5-{[1- (2,2,2- trifluoroethyl) piperidin-4-yl]oxy} benzamide::US10174016, Example 311::US10202369, Example 311::US10472354, Example 314 P2X purinoceptor 3 Homo sapiens 8.00 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320144 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320144&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397300 384223418 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843062 C[C@@H](NC(=O)c1cc(OC2CCN(CC(F)(F)F)CC2)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F InChI=1S/C25H25F6N5O2S/c1-14-12-32-23(39-14)17-9-16(22(37)33-15(2)20-3-4-21(35-34-20)25(29,30)31)10-19(11-17)38-18-5-7-36(8-6-18)13-24(26,27)28/h3-4,9-12,15,18H,5-8,13H2,1-2H3,(H,33,37)/t15-/m1/s1 AZRJUXHXOIFVSM-OAHLLOKOSA-N 320145 3-(5-methyl-1,3- thiazol-2-yl)-5-{[1- (2,2,2- trifluoroethyl) piperidin-4-yl]oxy}-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl}benzamide::US10174016, Example 312::US10202369, Example 312::US10472354, Example 312 P2X purinoceptor 3 Homo sapiens 9.00 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320145 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320145&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397364 384223419 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843064 C[C@@H](NC(=O)c1cc(OC2CCN(CC(F)(F)F)CC2)cc(c1)-c1ncc(C)s1)c1cnc(C)cn1 InChI=1S/C25H28F3N5O2S/c1-15-11-30-22(13-29-15)17(3)32-23(34)18-8-19(24-31-12-16(2)36-24)10-21(9-18)35-20-4-6-33(7-5-20)14-25(26,27)28/h8-13,17,20H,4-7,14H2,1-3H3,(H,32,34)/t17-/m1/s1 VOYLEHBGAUIAGN-QGZVFWFLSA-N 320146 N-[(1R)-1-(5- methylpyrazin-2- yl)ethyl]-3-(5- methyl-1,3- thiazol-2-yl)-5-{[1- (2,2,2- trifluoroethyl) piperidin-4- yl]oxy}benzamide::US10174016, Example 313::US10202369, Example 313::US10472354, Example 313 P2X purinoceptor 3 Homo sapiens 11.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320146 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320146&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397805 384223420 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843066 C[C@@H](NC(=O)c1cc(OC2CCN(CC(F)(F)F)CC2)cc(c1)-c1ncc(C)s1)c1ccc(C)nn1 InChI=1S/C25H28F3N5O2S/c1-15-4-5-22(32-31-15)17(3)30-23(34)18-10-19(24-29-13-16(2)36-24)12-21(11-18)35-20-6-8-33(9-7-20)14-25(26,27)28/h4-5,10-13,17,20H,6-9,14H2,1-3H3,(H,30,34)/t17-/m1/s1 PEAPNGOBIXQGEJ-QGZVFWFLSA-N 320144 N-[(1R)-1-(6- methylpyridazin-3- yl)ethyl]-3-(5- methyl-1,3- thiazol-2-yl)-5-{[1- (2,2,2- trifluoroethyl) piperidin-4-yl]oxy} benzamide::US10174016, Example 311::US10202369, Example 311::US10472354, Example 314 P2X purinoceptor 3 Homo sapiens 8.00 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320144 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320144&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397300 384223418 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843068 C[C@@H](NC(=O)c1cc(OC2CCN(CC(F)(F)F)CC2)cc(c1)-c1ncc(C)s1)c1cnc(C)nc1 InChI=1S/C25H28F3N5O2S/c1-15-11-31-24(36-15)19-8-18(23(34)32-16(2)20-12-29-17(3)30-13-20)9-22(10-19)35-21-4-6-33(7-5-21)14-25(26,27)28/h8-13,16,21H,4-7,14H2,1-3H3,(H,32,34)/t16-/m1/s1 CJWKMIQNKLHRQL-MRXNPFEDSA-N 320148 N-[(1R)-1-(2- methylpyrimidin- 5-yl)ethyl]-3-(5- methyl-1,3- thiazol-2-yl)-5-{[1- (2,2,2- trifluoroethyl) piperidin-4-yl]oxy} benzamide::US10174016, Example 315::US10202369, Example 315::US10472354, Example 315 P2X purinoceptor 3 Homo sapiens 8.00 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320148 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320148&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397608 384223422 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843070 C[C@@H](NC(=O)c1cc(OC[C@H]2CCOC2)cc(c1)-c1ncc(Cl)s1)c1ccc(C)nn1 InChI=1S/C22H23ClN4O3S/c1-13-3-4-19(27-26-13)14(2)25-21(28)16-7-17(22-24-10-20(23)31-22)9-18(8-16)30-12-15-5-6-29-11-15/h3-4,7-10,14-15H,5-6,11-12H2,1-2H3,(H,25,28)/t14-,15+/m1/s1 OPFRVFRBCBSDJR-CABCVRRESA-N 320149 3-(5-chloro-1,3- thiazol-2-yl)-N- [(1R)-1-(6- methylpyridazin-3- yl)ethyl]-5-[(3S)- tetrahydrofuran-3- ylmethoxy]benzamide::US10174016, Example 316::US10472354, Example 316 P2X purinoceptor 3 Homo sapiens 21.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320149 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320149&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397598 384223423 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843072 C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(Cl)s1)c1ccc(C)nn1 InChI=1S/C21H21ClN4O3S/c1-12-3-4-18(26-25-12)13(2)24-20(27)14-7-15(21-23-10-19(22)30-21)9-17(8-14)29-16-5-6-28-11-16/h3-4,7-10,13,16H,5-6,11H2,1-2H3,(H,24,27)/t13-,16-/m1/s1 GKNCXHRLEQHNKW-CZUORRHYSA-N 320150 3-(5-chloro-1,3- thiazol-2-yl)-N- [(1R)-1-(6- methylpyridazin-3- yl)ethyl]-5-[(3R)- tetrahydrofuran-3- yloxy]benzamide::US10174016, Example 317::US10202369, Example 317::US10472354, Example 317 P2X purinoceptor 3 Homo sapiens 45.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320150 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320150&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397433 384223424 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843074 C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(Cl)s1)c1ccc(nn1)C(F)(F)F InChI=1S/C21H18ClF3N4O3S/c1-11(16-2-3-17(29-28-16)21(23,24)25)27-19(30)12-6-13(20-26-9-18(22)33-20)8-15(7-12)32-14-4-5-31-10-14/h2-3,6-9,11,14H,4-5,10H2,1H3,(H,27,30)/t11-,14-/m1/s1 WZQSUVWYIQCPQJ-BXUZGUMPSA-N 320151 3-(5-chloro-1,3- thiazol-2-yl)-5- [(3R)- tetrahydrofuran-3- yloxy]-N-{(1R)-1- [6- (trifluoromethyl) pyridazin-3- yl]ethyl}benzamide::US10174016, Example 318::US10202369, Example 318::US10472354, Example 318 P2X purinoceptor 3 Homo sapiens 32.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320151 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320151&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397509 384223425 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843076 C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(Cl)s1)c1cnc(C)cn1 InChI=1S/C21H21ClN4O3S/c1-12-8-24-18(9-23-12)13(2)26-20(27)14-5-15(21-25-10-19(22)30-21)7-17(6-14)29-16-3-4-28-11-16/h5-10,13,16H,3-4,11H2,1-2H3,(H,26,27)/t13-,16-/m1/s1 NPEHDEPJRQIOFY-CZUORRHYSA-N 320152 3-(5-chloro-1,3- thiazol-2-yl)-N- [(1R)-1-(5- methylpyrazin-2- yl)ethyl]-5-[(3R)- tetrahydrofuran-3- yloxy]benzamide::US10174016, Example 319::US10202369, Example 319::US10472354, Example 319 P2X purinoceptor 3 Homo sapiens 76.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320152 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320152&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397412 384223426 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843078 C[C@@H](NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(Cl)s1)c1ccc(nn1)C(F)(F)F InChI=1S/C21H18ClF3N4O3S/c1-11(16-2-3-17(29-28-16)21(23,24)25)27-19(30)12-6-13(20-26-9-18(22)33-20)8-15(7-12)32-14-4-5-31-10-14/h2-3,6-9,11,14H,4-5,10H2,1H3,(H,27,30)/t11-,14+/m1/s1 WZQSUVWYIQCPQJ-RISCZKNCSA-N 320153 3-(5-chloro-1,3- thiazol-2-yl)-5- [(3S)- tetrahydrofuran-3- yloxy]-N-{(1R)-1- [6- (trifluoromethyl) pyridazin-3- yl]ethyl}benzamide::US10174016, Example 320::US10202369, Example 320::US10472354, Example 320 P2X purinoceptor 3 Homo sapiens 33.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320153 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320153&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397157 384223427 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843080 C[C@@H](NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(Cl)s1)c1cnc(C)cn1 InChI=1S/C21H21ClN4O3S/c1-12-8-24-18(9-23-12)13(2)26-20(27)14-5-15(21-25-10-19(22)30-21)7-17(6-14)29-16-3-4-28-11-16/h5-10,13,16H,3-4,11H2,1-2H3,(H,26,27)/t13-,16+/m1/s1 NPEHDEPJRQIOFY-CJNGLKHVSA-N 320154 3-(5-chloro-1,3- thiazol-2-yl)-N- [(1R)-1-(5- methylpyrazin-2- yl)ethyl]-5-[(3S)- tetrahydrofuran-3- yloxy]benzamide::US10174016, Example 321::US10202369, Example 321::US10472354, Example 321 P2X purinoceptor 3 Homo sapiens 120 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320154 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320154&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397403 384223428 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843082 C[C@@H](NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(Cl)s1)c1ccc(C)nn1 InChI=1S/C21H21ClN4O3S/c1-12-3-4-18(26-25-12)13(2)24-20(27)14-7-15(21-23-10-19(22)30-21)9-17(8-14)29-16-5-6-28-11-16/h3-4,7-10,13,16H,5-6,11H2,1-2H3,(H,24,27)/t13-,16+/m1/s1 GKNCXHRLEQHNKW-CJNGLKHVSA-N 320155 3-(5-chloro-1,3- thiazol-2-yl)-N- [(1R)-1-(6- methylpyridazin-3- yl)ethyl]-5-[(3S)- tetrahydrofuran-3- yloxy]benzamide::US10174016, Example 322::US10202369, Example 322::US10472354, Example 322 P2X purinoceptor 3 Homo sapiens 49.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320155 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320155&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397765 384223429 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843084 C[C@@H](NC(=O)c1cc(OC[C@H]2CCOC2)cc(c1)-c1ncc(Cl)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C22H20ClF3N4O3S/c1-12(16-7-28-21(29-8-16)22(24,25)26)30-19(31)14-4-15(20-27-9-18(23)34-20)6-17(5-14)33-11-13-2-3-32-10-13/h4-9,12-13H,2-3,10-11H2,1H3,(H,30,31)/t12-,13+/m1/s1 SQNSHDCXZQFUAQ-OLZOCXBDSA-N 320156 3-(5-chloro-1,3- thiazol-2-yl)-5- [(3S)- tetrahydrofuran-3- ylmethoxy]-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 323::US10202369, Example 323::US10472354, Example 323 P2X purinoceptor 3 Homo sapiens 25.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320156 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320156&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397761 384223430 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843086 C[C@@H](NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(Cl)s1)c1cnc(C)cn1 InChI=1S/C22H23ClN4O3S/c1-13-10-25-19(11-24-13)14(2)27-21(28)15-7-16(22-26-12-20(23)31-22)9-18(8-15)30-17-3-5-29-6-4-17/h7-12,14,17H,3-6H2,1-2H3,(H,27,28)/t14-/m1/s1 LHUVAVZJRUVQTK-CQSZACIVSA-N 320157 3-(5-chloro-1,3- thiazol-2-yl)-N- [(1R)-1-(5- methylpyrazin-2- yl)ethyl]-5- (tetrahydro-2H- pyran-4- yloxy)benzamide::US10174016, Example 324::US10202369, Example 324::US10472354, Example 324 P2X purinoceptor 3 Homo sapiens 46.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320157 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320157&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397374 384223431 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843088 C[C@@H](NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(Cl)s1)c1ccc(C)nn1 InChI=1S/C22H23ClN4O3S/c1-13-3-4-19(27-26-13)14(2)25-21(28)15-9-16(22-24-12-20(23)31-22)11-18(10-15)30-17-5-7-29-8-6-17/h3-4,9-12,14,17H,5-8H2,1-2H3,(H,25,28)/t14-/m1/s1 WDEIMZWFSWTCLU-CQSZACIVSA-N 320158 3-(5-chloro-1,3- thiazol-2-yl)-N- [(1R)-1-(6- methylpyridazin-3- yl)ethyl]-5- (tetrahydro-2H- pyran-4- yloxy)benzamide::US10174016, Example 325::US10202369, Example 325::US10472354, Example 325 P2X purinoceptor 3 Homo sapiens 26.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320158 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320158&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397325 384223432 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843090 C[C@@H](NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(Cl)s1)c1ccc(nn1)C(F)(F)F InChI=1S/C22H20ClF3N4O3S/c1-12(17-2-3-18(30-29-17)22(24,25)26)28-20(31)13-8-14(21-27-11-19(23)34-21)10-16(9-13)33-15-4-6-32-7-5-15/h2-3,8-12,15H,4-7H2,1H3,(H,28,31)/t12-/m1/s1 LBZPSHGDCXIMLR-GFCCVEGCSA-N 320159 3-(5-chloro-1,3- thiazol-2-yl)-5- (tetrahydro-2H- pyran-4-yloxy)-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl}benzamide::US10174016, Example 326::US10202369, Example 326::US10472354, Example 326 P2X purinoceptor 3 Homo sapiens 21.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320159 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320159&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397539 384223433 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843092 C[C@@H](NC(=O)c1cc(OCC2(C)COC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H23F3N4O3S/c1-13-7-27-20(34-13)16-4-15(5-18(6-16)33-12-22(3)10-32-11-22)19(31)30-14(2)17-8-28-21(29-9-17)23(24,25)26/h4-9,14H,10-12H2,1-3H3,(H,30,31)/t14-/m1/s1 JVDZTZBJXQINIP-CQSZACIVSA-N 320160 3-[(3- methyloxetan-3- yl)methoxy]-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 327::US10202369, Example 327::US10472354, Example 327 P2X purinoceptor 3 Homo sapiens 10.00 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320160 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320160&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397492 384223434 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843094 C[C@@H](NC(=O)c1cc(OCC(C)(C)O)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C22H23F3N4O3S/c1-12-8-26-19(33-12)15-5-14(6-17(7-15)32-11-21(3,4)31)18(30)29-13(2)16-9-27-20(28-10-16)22(23,24)25/h5-10,13,31H,11H2,1-4H3,(H,29,30)/t13-/m1/s1 CJANIGLDVDYTLU-CYBMUJFWSA-N 320161 3-(2-hydroxy-2- methylpropoxy)-5- (5-methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5-yl]ethyl} benzamide::US10174016, Example 328::US10472354, Example 328 P2X purinoceptor 3 Homo sapiens 12.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320161 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320161&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397727 384223435 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843096 C[C@@H](NC(=O)c1cc(OCC2(C)CCCO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H25F3N4O3S/c1-14-10-28-21(35-14)17-7-16(8-19(9-17)33-13-23(3)5-4-6-34-23)20(32)31-15(2)18-11-29-22(30-12-18)24(25,26)27/h7-12,15H,4-6,13H2,1-3H3,(H,31,32)/t15-,23?/m1/s1 LFYNTNZWPQXJEM-NKTHEXPSSA-N 320162 3-[(2-methyltetrahydrofuran-2-yl)methoxy]-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide, as a mixture of two diastereoisomers::US10174016, Example 329::US10202369, Example 330::US10472354, Example 332 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320162 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320162&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397698 384223436 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843098 C[C@@H](NC(=O)c1cc(OC[C@]2(C)CCCO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H25F3N4O3S/c1-14-10-28-21(35-14)17-7-16(8-19(9-17)33-13-23(3)5-4-6-34-23)20(32)31-15(2)18-11-29-22(30-12-18)24(25,26)27/h7-12,15H,4-6,13H2,1-3H3,(H,31,32)/t15-,23+/m1/s1 LFYNTNZWPQXJEM-CMJOXMDJSA-N 320164 US10174016, Example 331::US10472354, Example 333 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320164 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320164&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 138374910 384223438 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843100 C[C@@H](NC(=O)c1cc(OC[C@@]2(C)CCCO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H25F3N4O3S/c1-14-10-28-21(35-14)17-7-16(8-19(9-17)33-13-23(3)5-4-6-34-23)20(32)31-15(2)18-11-29-22(30-12-18)24(25,26)27/h7-12,15H,4-6,13H2,1-3H3,(H,31,32)/t15-,23-/m1/s1 LFYNTNZWPQXJEM-IQMFZBJNSA-N 320163 3-[(2-methyltetrahydrofuran-2-yl)methoxy]-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 330::US10472354, Example 334 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320163 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320163&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 138374909 384223437 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843102 C[C@@H](NC(=O)c1cc(OCC2(C)CCCO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H25F3N4O3S/c1-14-10-28-21(35-14)17-7-16(8-19(9-17)33-13-23(3)5-4-6-34-23)20(32)31-15(2)18-11-29-22(30-12-18)24(25,26)27/h7-12,15H,4-6,13H2,1-3H3,(H,31,32)/t15-,23?/m1/s1 LFYNTNZWPQXJEM-NKTHEXPSSA-N 320162 3-[(2-methyltetrahydrofuran-2-yl)methoxy]-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide, as a mixture of two diastereoisomers::US10174016, Example 329::US10202369, Example 330::US10472354, Example 332 P2X purinoceptor 3 Homo sapiens 4.00 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320162 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320162&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397698 384223436 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843104 C[C@@H](NC(=O)c1cc(OC[C@]2(C)CCCO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H25F3N4O3S/c1-14-10-28-21(35-14)17-7-16(8-19(9-17)33-13-23(3)5-4-6-34-23)20(32)31-15(2)18-11-29-22(30-12-18)24(25,26)27/h7-12,15H,4-6,13H2,1-3H3,(H,31,32)/t15-,23+/m1/s1 LFYNTNZWPQXJEM-CMJOXMDJSA-N 320164 US10174016, Example 331::US10472354, Example 333 P2X purinoceptor 3 Homo sapiens 4.00 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320164 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320164&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 138374910 384223438 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843106 C[C@@H](NC(=O)c1cc(OC[C@@]2(C)CCCO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H25F3N4O3S/c1-14-10-28-21(35-14)17-7-16(8-19(9-17)33-13-23(3)5-4-6-34-23)20(32)31-15(2)18-11-29-22(30-12-18)24(25,26)27/h7-12,15H,4-6,13H2,1-3H3,(H,31,32)/t15-,23-/m1/s1 LFYNTNZWPQXJEM-IQMFZBJNSA-N 320163 3-[(2-methyltetrahydrofuran-2-yl)methoxy]-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 330::US10472354, Example 334 P2X purinoceptor 3 Homo sapiens 4.00 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320163 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320163&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 138374909 384223437 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843108 C[C@@H](NC(=O)c1cc(OC2CCC(=O)N(C)C2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H24F3N5O3S/c1-13-9-28-22(36-13)16-6-15(7-19(8-16)35-18-4-5-20(33)32(3)12-18)21(34)31-14(2)17-10-29-23(30-11-17)24(25,26)27/h6-11,14,18H,4-5,12H2,1-3H3,(H,31,34)/t14-,18?/m1/s1 CGMVCPWOPCCFBE-IKJXHCRLSA-N 320168 3-[(1-methyl-6-oxopiperidin-3-yl)oxy]-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide, as a mixture of two diastereoisomers::US10174016, Example 335::US10202369, Example 336::US10472354, Example 335 P2X purinoceptor 3 Homo sapiens 13.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320168 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320168&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397147 384223442 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843110 C[C@@H](NC(=O)c1cc(O[C@@H]2CCC(=O)N(C)C2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H24F3N5O3S/c1-13-9-28-22(36-13)16-6-15(7-19(8-16)35-18-4-5-20(33)32(3)12-18)21(34)31-14(2)17-10-29-23(30-11-17)24(25,26)27/h6-11,14,18H,4-5,12H2,1-3H3,(H,31,34)/t14-,18-/m1/s1 CGMVCPWOPCCFBE-RDTXWAMCSA-N 320169 3-[(1-methyl-6-oxopiperidin-3-yl)oxy]-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 336::US10472354, Example 336 P2X purinoceptor 3 Homo sapiens 14.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320169 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320169&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 138374913 384223443 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843112 C[C@@H](NC(=O)c1cc(O[C@H]2CCC(=O)N(C)C2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H24F3N5O3S/c1-13-9-28-22(36-13)16-6-15(7-19(8-16)35-18-4-5-20(33)32(3)12-18)21(34)31-14(2)17-10-29-23(30-11-17)24(25,26)27/h6-11,14,18H,4-5,12H2,1-3H3,(H,31,34)/t14-,18+/m1/s1 CGMVCPWOPCCFBE-KDOFPFPSSA-N 320170 US10174016, Example 337::US10472354, Example 337 P2X purinoceptor 3 Homo sapiens 13.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320170 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320170&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 138374914 384223444 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843114 CC(O)C(C)Oc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C22H23F3N4O3S/c1-11-8-26-20(33-11)16-5-15(6-18(7-16)32-14(4)13(3)30)19(31)29-12(2)17-9-27-21(28-10-17)22(23,24)25/h5-10,12-14,30H,1-4H3,(H,29,31)/t12-,13?,14?/m1/s1 FSGDRFBLPAILDE-IYXRBSQSSA-N 319995 3-{[3-hydroxybutan-2-yl]oxy}-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 162::US10174016, Example 338::US10202369, Example 339::US10472354, Example 338 P2X purinoceptor 3 Homo sapiens 4.00 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319995 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319995&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397269 384223275 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843116 CC(O)[C@H](C)Oc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C22H23F3N4O3S/c1-11-8-26-20(33-11)16-5-15(6-18(7-16)32-14(4)13(3)30)19(31)29-12(2)17-9-27-21(28-10-17)22(23,24)25/h5-10,12-14,30H,1-4H3,(H,29,31)/t12-,13?,14+/m1/s1 FSGDRFBLPAILDE-YIOYIWSBSA-N 320172 3-[(3-hydroxybutan-2-yl)oxy]-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 339::US10472354, Example 339 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320172 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320172&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 138374915 384223445 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843118 CC(O)[C@@H](C)Oc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C22H23F3N4O3S/c1-11-8-26-20(33-11)16-5-15(6-18(7-16)32-14(4)13(3)30)19(31)29-12(2)17-9-27-21(28-10-17)22(23,24)25/h5-10,12-14,30H,1-4H3,(H,29,31)/t12-,13?,14-/m1/s1 FSGDRFBLPAILDE-WYAMFQBQSA-N 320173 US10174016, Example 340::US10472354, Example 340 P2X purinoceptor 3 Homo sapiens 3.00 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320173 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320173&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 138374916 384223446 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843120 C[C@@H](NC(=O)c1cc(OC2C3COCC2CN(C)C3)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C26H28F3N5O3S/c1-14-7-30-24(38-14)17-4-16(23(35)33-15(2)18-8-31-25(32-9-18)26(27,28)29)5-21(6-17)37-22-19-10-34(3)11-20(22)13-36-12-19/h4-9,15,19-20,22H,10-13H2,1-3H3,(H,33,35)/t15-,19?,20?,22?/m1/s1 UOQSAFNLRPUQCS-DSXPMEPHSA-N 320174 3-[(7-methyl-3-oxa-7-azabicyclo[3.3.1]non-9-yl)oxy]-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide, as a Mixture of Two Stereoisomers::US10174016, Example 341::US10202369, Example 342::US10472354, Example 343 P2X purinoceptor 3 Homo sapiens 41.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320174 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320174&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397140 384223447 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843122 C[C@@H](NC(=O)c1cc(OC2C3COCC2CN(C)C3)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C26H28F3N5O3S/c1-14-7-30-24(38-14)17-4-16(23(35)33-15(2)18-8-31-25(32-9-18)26(27,28)29)5-21(6-17)37-22-19-10-34(3)11-20(22)13-36-12-19/h4-9,15,19-20,22H,10-13H2,1-3H3,(H,33,35)/t15-,19?,20?,22?/m1/s1 UOQSAFNLRPUQCS-DSXPMEPHSA-N 320174 3-[(7-methyl-3-oxa-7-azabicyclo[3.3.1]non-9-yl)oxy]-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide, as a Mixture of Two Stereoisomers::US10174016, Example 341::US10202369, Example 342::US10472354, Example 343 P2X purinoceptor 3 Homo sapiens 40.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320174 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320174&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397140 384223447 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843124 C[C@@H](NC(=O)c1cc(OC2C3COCC2CN(C)C3)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C26H28F3N5O3S/c1-14-7-30-24(38-14)17-4-16(23(35)33-15(2)18-8-31-25(32-9-18)26(27,28)29)5-21(6-17)37-22-19-10-34(3)11-20(22)13-36-12-19/h4-9,15,19-20,22H,10-13H2,1-3H3,(H,33,35)/t15-,19?,20?,22?/m1/s1 UOQSAFNLRPUQCS-DSXPMEPHSA-N 320174 3-[(7-methyl-3-oxa-7-azabicyclo[3.3.1]non-9-yl)oxy]-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide, as a Mixture of Two Stereoisomers::US10174016, Example 341::US10202369, Example 342::US10472354, Example 343 P2X purinoceptor 3 Homo sapiens 135 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320174 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320174&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397140 384223447 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843126 CC(C)N1CC2COCC(C1)C2Oc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C28H32F3N5O3S/c1-15(2)36-11-21-13-38-14-22(12-36)24(21)39-23-6-18(5-19(7-23)26-32-8-16(3)40-26)25(37)35-17(4)20-9-33-27(34-10-20)28(29,30)31/h5-10,15,17,21-22,24H,11-14H2,1-4H3,(H,35,37)/t17-,21?,22?,24?/m1/s1 IQKMSJWJAJKSIQ-CBDSMJNHSA-N 320177 3-[(7-isopropyl-3-oxa-7-azabicyclo[3.3.1]non-9-yl)oxy]-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide, as a mixture of two stereoisomers::US10174016, Example 344::US10202369, Example 344::US10472354, Example 344 P2X purinoceptor 3 Homo sapiens 34.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320177 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320177&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397285 384223450 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843128 COC(C)N1CC2COCC(C1)C2Oc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F InChI=1S/C28H32F3N5O4S/c1-15-8-32-26(41-15)19-5-18(25(37)35-16(2)20-9-33-27(34-10-20)28(29,30)31)6-23(7-19)40-24-21-11-36(17(3)38-4)12-22(24)14-39-13-21/h5-10,16-17,21-22,24H,11-14H2,1-4H3,(H,35,37)/t16-,17?,21?,22?,24?/m1/s1 CFYKAOKHKJAYDP-TYFPZMBFSA-N 420284 US10472354, Example 345::methyl 9-[3-(5-methyl-1,3-thiazol-2-yl)-5-({(1R)-1-[2-(trifluoro-methyl)pyrimidin-5-yl]ethyl}carbamoyl)phenoxy]-3-oxa-7-azabicycle[3.3.1]nonane-7-carboxylate, as a Mixture of Two Stereoisomers P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=420284 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=420284&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843130 C[C@@H](NC(=O)c1cc(OC[C@H]2CN(CCO2)C(=O)OC(C)(C)C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C28H32F3N5O5S/c1-16-11-32-24(42-16)19-8-18(23(37)35-17(2)20-12-33-25(34-13-20)28(29,30)31)9-21(10-19)40-15-22-14-36(6-7-39-22)26(38)41-27(3,4)5/h8-13,17,22H,6-7,14-15H2,1-5H3,(H,35,37)/t17-,22-/m1/s1 OEKUZTDVCYAZBS-VGOFRKELSA-N 320179 Tert-butyl (2R)-2-{[3-(5-methyl-1,3-thiazol-2-yl)-5-({(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}carbamoyl)phenoxy]methyl}morpholine-4-carboxylate::US10174016, Example 346::US10202369, Example 346::US10472354, Example 346 P2X purinoceptor 3 Homo sapiens 13.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320179 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320179&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134338449 384223452 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843132 C[C@@H](NC(=O)c1cc(OC[C@H]2CNCCO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H24F3N5O3S/c1-13-8-28-21(35-13)16-5-15(6-18(7-16)34-12-19-11-27-3-4-33-19)20(32)31-14(2)17-9-29-22(30-10-17)23(24,25)26/h5-10,14,19,27H,3-4,11-12H2,1-2H3,(H,31,32)/t14-,19-/m1/s1 HRVUBTPQOQIHTK-AUUYWEPGSA-N 320180 3-(5-Methyl-1,3-thiazol-2-yl)-5-[(2R)-morpholin-2-ylmethoxy]-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 347::US10202369, Example 347::US10472354, Example 347 P2X purinoceptor 3 Homo sapiens 9.00 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320180 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320180&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397601 384223453 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843134 C[C@@H](NC(=O)c1cc(OC[C@H]2CN(C)CCO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H26F3N5O3S/c1-14-9-28-22(36-14)17-6-16(7-19(8-17)35-13-20-12-32(3)4-5-34-20)21(33)31-15(2)18-10-29-23(30-11-18)24(25,26)27/h6-11,15,20H,4-5,12-13H2,1-3H3,(H,31,33)/t15-,20-/m1/s1 MROBUJILSMBILX-FOIQADDNSA-N 320181 3-{[(2R)-4-methylmorpholin-2-yl]methoxy}-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 348::US10202369, Example 348::US10472354, Example 348 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320181 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320181&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397607 384223454 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843136 C[C@@H](NC(=O)c1cc(OC[C@@H]2CN(CCO2)C(=O)OC(C)(C)C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C28H32F3N5O5S/c1-16-11-32-24(42-16)19-8-18(23(37)35-17(2)20-12-33-25(34-13-20)28(29,30)31)9-21(10-19)40-15-22-14-36(6-7-39-22)26(38)41-27(3,4)5/h8-13,17,22H,6-7,14-15H2,1-5H3,(H,35,37)/t17-,22+/m1/s1 OEKUZTDVCYAZBS-VGSWGCGISA-N 320182 Tert-butyl (2S)-2-{[3-(5-methyl-1,3-thiazol-2-yl)-5-({(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}carbamoyl)phenoxy]methyl}morpholine-4-carboxylate::US10174016, Example 349::US10202369, Example 349::US10472354, Example 349 P2X purinoceptor 3 Homo sapiens 23.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320182 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320182&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134338450 384223455 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843138 C[C@@H](NC(=O)c1cc(OC[C@@H]2CNCCO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H24F3N5O3S/c1-13-8-28-21(35-13)16-5-15(6-18(7-16)34-12-19-11-27-3-4-33-19)20(32)31-14(2)17-9-29-22(30-10-17)23(24,25)26/h5-10,14,19,27H,3-4,11-12H2,1-2H3,(H,31,32)/t14-,19+/m1/s1 HRVUBTPQOQIHTK-KUHUBIRLSA-N 320183 3-(5-Methyl-1,3-thiazol-2-yl)-5-[(2S)-morpholin-2-ylmethoxy]-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 350::US10202369, Example 350::US10472354, Example 350 P2X purinoceptor 3 Homo sapiens 14.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320183 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320183&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397343 384223456 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843140 C[C@@H](NC(=O)c1cc(OC[C@@H]2CN(C)CCO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H26F3N5O3S/c1-14-9-28-22(36-14)17-6-16(7-19(8-17)35-13-20-12-32(3)4-5-34-20)21(33)31-15(2)18-10-29-23(30-11-18)24(25,26)27/h6-11,15,20H,4-5,12-13H2,1-3H3,(H,31,33)/t15-,20+/m1/s1 MROBUJILSMBILX-QRWLVFNGSA-N 320184 3-{[(2S)-4-methylmorpholin-2-yl]methoxy}-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 351::US10202369, Example 351::US10472354, Example 351 P2X purinoceptor 3 Homo sapiens 16.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320184 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320184&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397379 384223457 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843142 C[C@@H](NC(=O)c1cc(OCC2CNCCO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C23H24F3N5O3S/c1-13-8-28-21(35-13)16-5-15(6-18(7-16)34-12-19-11-27-3-4-33-19)20(32)31-14(2)17-9-29-22(30-10-17)23(24,25)26/h5-10,14,19,27H,3-4,11-12H2,1-2H3,(H,31,32)/t14-,19?/m1/s1 HRVUBTPQOQIHTK-MJTSIZKDSA-N 320185 3-(5-Methyl-1,3-thiazol-2-yl)-5-[morpholin-2-ylmethoxy]-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide, Formed as a Mixture of Example 347 (Diastereoisomer 1) and Example 350 (Diastereoisomer 2)::US10174016, Example 352::US10202369, Example 352::US10472354, Example 352 P2X purinoceptor 3 Homo sapiens 18.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320185 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320185&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397625 384223458 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843144 C[C@@H](NC(=O)c1cc(OCC2CN(C)CCO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H26F3N5O3S/c1-14-9-28-22(36-14)17-6-16(7-19(8-17)35-13-20-12-32(3)4-5-34-20)21(33)31-15(2)18-10-29-23(30-11-18)24(25,26)27/h6-11,15,20H,4-5,12-13H2,1-3H3,(H,31,33)/t15-,20?/m1/s1 MROBUJILSMBILX-IWPPFLRJSA-N 320186 3-{[4-methylmorpholin-2-yl]methoxy}-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide, formed as a mixture of Example 348 (Diastereoisomer 2) and Example 351 (Diastereoisomer 1)::US10174016, Example 353::US10202369, Example 353::US10472354, Example 353 P2X purinoceptor 3 Homo sapiens 7.00 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320186 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320186&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397299 384223459 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843146 C[C@@H](NC(=O)c1cc(OC[C@@]2(F)CCCNC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H25F4N5O2S/c1-14-9-30-21(36-14)17-6-16(7-19(8-17)35-13-23(25)4-3-5-29-12-23)20(34)33-15(2)18-10-31-22(32-11-18)24(26,27)28/h6-11,15,29H,3-5,12-13H2,1-2H3,(H,33,34)/t15-,23-/m1/s1 KEYDTZMORFCFGJ-IQMFZBJNSA-N 320187 3-(Fluoropiperidin-3-yl)methoxyl}-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 354::US10472354, Example 354 P2X purinoceptor 3 Homo sapiens 25.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320187 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320187&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 138374918 384223460 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843148 C[C@@H](NC(=O)c1cc(OC[C@]2(F)CCCNC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H25F4N5O2S/c1-14-9-30-21(36-14)17-6-16(7-19(8-17)35-13-23(25)4-3-5-29-12-23)20(34)33-15(2)18-10-31-22(32-11-18)24(26,27)28/h6-11,15,29H,3-5,12-13H2,1-2H3,(H,33,34)/t15-,23+/m1/s1 KEYDTZMORFCFGJ-CMJOXMDJSA-N 320188 US10174016, Example 355::US10472354, Example 355 P2X purinoceptor 3 Homo sapiens 9.00 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320188 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320188&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 138374919 384223461 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843150 C[C@@H](NC(=O)c1cc(OC[C@@]2(F)CCCN(C)C2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C25H27F4N5O2S/c1-15-10-30-22(37-15)18-7-17(8-20(9-18)36-14-24(26)5-4-6-34(3)13-24)21(35)33-16(2)19-11-31-23(32-12-19)25(27,28)29/h7-12,16H,4-6,13-14H2,1-3H3,(H,33,35)/t16-,24-/m1/s1 JEEGJUGZAOELQB-VOIUYBSRSA-N 320189 3-{[3-fluoro-1-methylpiperidin-3-yl]methoxy}-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 356::US10472354, Example 356 P2X purinoceptor 3 Homo sapiens 29.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320189 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320189&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 138374920 384223462 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843152 C[C@@H](NC(=O)c1cc(OC[C@]2(F)CCCN(C)C2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C25H27F4N5O2S/c1-15-10-30-22(37-15)18-7-17(8-20(9-18)36-14-24(26)5-4-6-34(3)13-24)21(35)33-16(2)19-11-31-23(32-12-19)25(27,28)29/h7-12,16H,4-6,13-14H2,1-3H3,(H,33,35)/t16-,24+/m1/s1 JEEGJUGZAOELQB-GYCJOSAFSA-N 320190 US10174016, Example 357::US10472354, Example 357 P2X purinoceptor 3 Homo sapiens 5.00 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320190 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320190&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 138374921 384223463 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843154 C[C@@H](NC(=O)c1cc(OCC2(F)CNC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C22H21F4N5O2S/c1-12-6-28-19(34-12)15-3-14(4-17(5-15)33-11-21(23)9-27-10-21)18(32)31-13(2)16-7-29-20(30-8-16)22(24,25)26/h3-8,13,27H,9-11H2,1-2H3,(H,31,32)/t13-/m1/s1 BCJGFEUMNVQMPR-CYBMUJFWSA-N 320191 3-[(3- fluoroazetidin- 3-yl)methoxy]- 5-(5-methyl- 1,3-thiazol-2- yl)-N-{(1R)-1- [2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 358::US10202369, Example 358::US10472354, Example 358 P2X purinoceptor 3 Homo sapiens 57.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320191 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320191&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397395 384223464 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843156 C[C@@H](NC(=O)c1cc(OCC2CNCCC2(F)F)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H24F5N5O2S/c1-13-8-31-21(37-13)16-5-15(6-19(7-16)36-12-18-11-30-4-3-23(18,25)26)20(35)34-14(2)17-9-32-22(33-10-17)24(27,28)29/h5-10,14,18,30H,3-4,11-12H2,1-2H3,(H,34,35)/t14-,18?/m1/s1 GMFUIUUSPXQCGC-IKJXHCRLSA-N 320192 3-{[4,4- difluoropiperidin- 3- yl]methoxy}-5- (5-methyl-1,3- thiazol-2-yl)- N-{(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide, as a mixture of 2 diastereoisomers::US10174016, Example 359::US10202369, Example 359::US10472354, Example 359 P2X purinoceptor 3 Homo sapiens 6.00 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320192 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320192&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397568 384223465 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843158 C[C@@H](NC(=O)c1cc(OC[C@H]2COCCN2C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H26F3N5O3S/c1-14-9-28-22(36-14)17-6-16(7-20(8-17)35-13-19-12-34-5-4-32(19)3)21(33)31-15(2)18-10-29-23(30-11-18)24(25,26)27/h6-11,15,19H,4-5,12-13H2,1-3H3,(H,31,33)/t15-,19-/m1/s1 QQIYVSYWBHUFSE-DNVCBOLYSA-N 320193 3-{[(3R)-4-methylmorpholin-3-yl]methoxyl}-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 360::US10202369, Example 360::US10472354, Example 360 P2X purinoceptor 3 Homo sapiens 10.00 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320193 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320193&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397664 384223466 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843160 C[C@@H](NC(=O)c1cc(OC[C@@H]2COCCN2C)cc(c1)-c1ncc(C)s1)c1ccc(nc1)C(F)(F)F InChI=1S/C25H27F3N4O3S/c1-15-11-30-24(36-15)19-8-18(9-21(10-19)35-14-20-13-34-7-6-32(20)3)23(33)31-16(2)17-4-5-22(29-12-17)25(26,27)28/h4-5,8-12,16,20H,6-7,13-14H2,1-3H3,(H,31,33)/t16-,20+/m1/s1 VDLXIDIXMUFWTI-UZLBHIALSA-N 320194 3-{[(3S)-4- methylmorpholin- 3- yl]methoxy}-5- (5-methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[6- (trifluoromethyl) pyridin-3- yl]ethyl} benzamide::US10174016, Example 361::US10202369, Example 361::US10472354, Example 361 P2X purinoceptor 3 Homo sapiens 14.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320194 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320194&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397445 384223467 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843162 C[C@@H](NC(=O)c1cc(OC[C@@H]2COCCN2C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H26F3N5O3S/c1-14-9-28-22(36-14)17-6-16(7-20(8-17)35-13-19-12-34-5-4-32(19)3)21(33)31-15(2)18-10-29-23(30-11-18)24(25,26)27/h6-11,15,19H,4-5,12-13H2,1-3H3,(H,31,33)/t15-,19+/m1/s1 QQIYVSYWBHUFSE-BEFAXECRSA-N 320195 3-{[(3S)-4- methylmorpholin- 3- yl]methoxy}-5- (5-methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyridin-5- yl]ethyl} benzamide::US10174016, Example 362::US10202369, Example 362::US10472354, Example 362 P2X purinoceptor 3 Homo sapiens 8.00 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320195 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320195&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397415 384223468 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843164 C[C@@H](NC(=O)c1cc(OC[C@H]2COCCN2C)cc(c1)-c1ncc(C)s1)c1ccc(nc1)C(F)(F)F InChI=1S/C25H27F3N4O3S/c1-15-11-30-24(36-15)19-8-18(9-21(10-19)35-14-20-13-34-7-6-32(20)3)23(33)31-16(2)17-4-5-22(29-12-17)25(26,27)28/h4-5,8-12,16,20H,6-7,13-14H2,1-3H3,(H,31,33)/t16-,20-/m1/s1 VDLXIDIXMUFWTI-OXQOHEQNSA-N 320196 3-{[(3R)-4- methylmorpholin- 3- yl]methoxy}-5- (5-methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[6- (trifluoromethyl) pyridin-3- yl]ethyl} benzamide::US10174016, Example 363::US10472354, Example 363 P2X purinoceptor 3 Homo sapiens 12.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320196 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320196&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397368 384223469 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843166 C[C@@H](NC(=O)c1cc(OCC2CC(F)CN2C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C24H25F4N5O2S/c1-13-8-29-22(36-13)16-4-15(5-20(6-16)35-12-19-7-18(25)11-33(19)3)21(34)32-14(2)17-9-30-23(31-10-17)24(26,27)28/h4-6,8-10,14,18-19H,7,11-12H2,1-3H3,(H,32,34)/t14-,18?,19?/m1/s1 UCQIVXMFKURDDU-FTXHTYHOSA-N 320197 3-{[4-fluoro-1- methylpyrrolidin- 2- yl]methoxy}-5- (5-methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide, as a mixture of stereoisomers::US10174016, Example 364::US10202369, Example 364::US10472354, Example 364 P2X purinoceptor 3 Homo sapiens 16.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320197 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320197&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397240 384223470 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 843168 C[C@@H](NC(=O)c1cc(OCC2CC(F)CN2C)cc(c1)-c1ncc(C)s1)c1ccc(nc1)C(F)(F)F InChI=1S/C25H26F4N4O2S/c1-14-10-31-24(36-14)18-6-17(7-21(8-18)35-13-20-9-19(26)12-33(20)3)23(34)32-15(2)16-4-5-22(30-11-16)25(27,28)29/h4-8,10-11,15,19-20H,9,12-13H2,1-3H3,(H,32,34)/t15-,19?,20?/m1/s1 XNRRWTQJTXNPEU-APMMTJHUSA-N 320198 3-{[4-fluoro-1- methylpyrrolidin- 2- yl]methoxy}-5- (5-methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[6- (trifluoromethyl) pyridin-3- yl]ethyl} benzamide, as a mixture of stereoisomers::US10174016, Example 365::US10202369, Example 365::US10472354, Example 365 P2X purinoceptor 3 Homo sapiens 21.0 US Patent 10.7270/Q2KD2197 aid1803961 US10472354 Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J Bayer Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320198 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320198&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397581 384223471 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51236560 NS(=O)(=O)c1cc(NC(=O)Cc2ccccc2)ccc1Oc1cccc(Cl)c1 InChI=1S/C20H17ClN2O4S/c21-15-7-4-8-17(12-15)27-18-10-9-16(13-19(18)28(22,25)26)23-20(24)11-14-5-2-1-3-6-14/h1-10,12-13H,11H2,(H,23,24)(H2,22,25,26) CSJYMAFXYMYNCK-UHFFFAOYSA-N 50506158 CHEMBL4521594 P2X purinoceptor 3 Homo sapiens 8300 ChEMBL 10.1021/acs.jmedchem.9b01304 10.7270/Q2M048RW 31746599 Werner, S; Mesch, S; Hillig, RC; Ter Laak, A; Klint, J; Neagoe, I; Laux-Biehlmann, A; Dahllöf, H; Bräuer, N; Puetter, V; Nubbemeyer, R; Schulz, S; Bairlein, M; Zollner, TM; Steinmeyer, A Bayer AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50506158 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50506158&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 124125214 440714743 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51275389 CNC(=O)O[C@@H](CC(C)C)c1nc(cs1)[C@H]1OC(=O)C\C=C\C(\C)=C\[C@@H](O)[C@@H](C)\C=C(\C)/C=C(/C)\C=C\[C@@H](O)[C@H](C)[C@H](O)\C(C)=C\C=C\[C@@H]1C InChI=1S/C40H58N2O7S/c1-24(2)19-35(48-40(47)41-10)39-42-32(23-50-39)38-29(7)15-12-14-28(6)37(46)31(9)33(43)18-17-26(4)20-27(5)21-30(8)34(44)22-25(3)13-11-16-36(45)49-38/h11-15,17-18,20-24,29-31,33-35,37-38,43-44,46H,16,19H2,1-10H3,(H,41,47)/b13-11+,15-12+,18-17+,25-22+,26-20-,27-21-,28-14+/t29-,30-,31-,33+,34+,35-,37+,38-/m0/s1 TVOXGUCNTJQSOX-YXKAYWIHSA-N 50520502 CHEMBL4447903 P2X purinoceptor 3 Homo sapiens >10000 ChEMBL 10.1021/acs.jmedchem.9b01887 10.7270/Q2NZ8C2N 31990540 Scheeff, S; Rivière, S; Ruiz, J; Abdelrahman, A; Schulz-Fincke, AC; Köse, M; Tiburcy, F; Wieczorek, H; Gütschow, M; Müller, CE; Menche, D Universit£t Bonn http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50520502 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50520502&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155519617 440729084 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51275399 CNC(=O)O[C@@H](CC(C)C)c1nc(cs1)[C@H]1OC(=O)[C@H](C)\C=C\C(\C)=C\[C@@H](O)[C@@H](C)\C=C(\C)/C=C(/C)\C=C\[C@@H](O)[C@H](C)[C@H](OC)\C(C)=C\C=C\[C@@H]1C InChI=1S/C42H62N2O7S/c1-25(2)20-37(50-42(48)43-11)40-44-34(24-52-40)39-30(7)15-13-14-29(6)38(49-12)33(10)35(45)19-17-26(3)21-28(5)22-32(9)36(46)23-27(4)16-18-31(8)41(47)51-39/h13-19,21-25,30-33,35-39,45-46H,20H2,1-12H3,(H,43,48)/b15-13+,18-16+,19-17+,26-21-,27-23+,28-22-,29-14+/t30-,31+,32-,33-,35+,36+,37-,38+,39-/m0/s1 AKHUMVIUALSLOB-MUKVDSILSA-N 50520504 CHEMBL4460252 P2X purinoceptor 3 Homo sapiens >2000 ChEMBL 10.1021/acs.jmedchem.9b01887 10.7270/Q2NZ8C2N 31990540 Scheeff, S; Rivière, S; Ruiz, J; Abdelrahman, A; Schulz-Fincke, AC; Köse, M; Tiburcy, F; Wieczorek, H; Gütschow, M; Müller, CE; Menche, D Universit£t Bonn http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50520504 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50520504&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155528080 440729086 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51275400 CNC(=O)O[C@@H](CC(C)C)c1nc(cs1)[C@H]1OC(=O)[C@@H](C)\C=C\C(\C)=C\[C@@H](O)[C@@H](C)\C=C(\C)/C=C(/C)\C=C\[C@@H](O)[C@H](C)[C@H](OC)\C(C)=C\C=C\[C@@H]1C InChI=1S/C42H62N2O7S/c1-25(2)20-37(50-42(48)43-11)40-44-34(24-52-40)39-30(7)15-13-14-29(6)38(49-12)33(10)35(45)19-17-26(3)21-28(5)22-32(9)36(46)23-27(4)16-18-31(8)41(47)51-39/h13-19,21-25,30-33,35-39,45-46H,20H2,1-12H3,(H,43,48)/b15-13+,18-16+,19-17+,26-21-,27-23+,28-22-,29-14+/t30-,31-,32-,33-,35+,36+,37-,38+,39-/m0/s1 AKHUMVIUALSLOB-KVBJCGRFSA-N 50520505 CHEMBL4593430 P2X purinoceptor 3 Homo sapiens 648 ChEMBL 10.1021/acs.jmedchem.9b01887 10.7270/Q2NZ8C2N 31990540 Scheeff, S; Rivière, S; Ruiz, J; Abdelrahman, A; Schulz-Fincke, AC; Köse, M; Tiburcy, F; Wieczorek, H; Gütschow, M; Müller, CE; Menche, D Universit£t Bonn http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50520505 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50520505&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155569370 440729087 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51275401 CNC(=O)O[C@@H](CC(C)C)c1nc(cs1)[C@H]1OC(=O)\C=C\C\C(C)=C\[C@@H](O)[C@@H](C)\C=C(\C)/C=C(/C)\C=C\[C@@H](O)[C@H](C)[C@H](OC)\C(C)=C\C=C\[C@@H]1C InChI=1S/C41H60N2O7S/c1-25(2)20-36(49-41(47)42-10)40-43-33(24-51-40)39-30(7)16-13-15-29(6)38(48-11)32(9)34(44)19-18-27(4)21-28(5)22-31(8)35(45)23-26(3)14-12-17-37(46)50-39/h12-13,15-19,21-25,30-32,34-36,38-39,44-45H,14,20H2,1-11H3,(H,42,47)/b16-13+,17-12+,19-18+,26-23+,27-21-,28-22-,29-15+/t30-,31-,32-,34+,35+,36-,38+,39-/m0/s1 BYVUBCIRZIXXCV-OZCJWKDYSA-N 50483928 ARCHAZOLID B P2X purinoceptor 3 Homo sapiens 353 ChEMBL 10.1021/acs.jmedchem.9b01887 10.7270/Q2NZ8C2N 31990540 Scheeff, S; Rivière, S; Ruiz, J; Abdelrahman, A; Schulz-Fincke, AC; Köse, M; Tiburcy, F; Wieczorek, H; Gütschow, M; Müller, CE; Menche, D Universit£t Bonn http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50483928 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50483928&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 16757019 433951193 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51275402 CNC(=O)O[C@@H](CC(C)C)c1nc(cs1)[C@H]1OC(=O)\C(C)=C\C\C(C)=C\[C@@H](O)[C@@H](C)\C=C(\C)/C=C(/C)\C=C\[C@@H](O)[C@H](C)[C@H](OC)\C(C)=C\C=C\[C@@H]1C InChI=1S/C42H62N2O7S/c1-25(2)20-37(50-42(48)43-11)40-44-34(24-52-40)39-30(7)15-13-14-29(6)38(49-12)33(10)35(45)19-17-26(3)21-28(5)22-32(9)36(46)23-27(4)16-18-31(8)41(47)51-39/h13-15,17-19,21-25,30,32-33,35-39,45-46H,16,20H2,1-12H3,(H,43,48)/b15-13+,19-17+,26-21-,27-23+,28-22-,29-14+,31-18+/t30-,32-,33-,35+,36+,37-,38+,39-/m0/s1 CUYVVUGLFUIZAZ-YYRKZZGWSA-N 50178305 ARCHAZOLID A P2X purinoceptor 3 Homo sapiens 86 ChEMBL 10.1021/acs.jmedchem.9b01887 10.7270/Q2NZ8C2N 31990540 Scheeff, S; Rivière, S; Ruiz, J; Abdelrahman, A; Schulz-Fincke, AC; Köse, M; Tiburcy, F; Wieczorek, H; Gütschow, M; Müller, CE; Menche, D Universit£t Bonn http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50178305 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50178305&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search KJL 7TAP 16680454 346549415 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51275404 CO[C@H]1[C@@H](C)[C@H](O)\C=C\C(\C)=C/C(/C)=C\[C@H](C)[C@H](O)\C=C(/C)\C=C\CC(=O)OCC\C=C\C=C1/C InChI=1S/C30H44O5/c1-21-12-11-14-29(33)35-17-10-8-9-13-24(4)30(34-7)26(6)27(31)16-15-22(2)18-23(3)19-25(5)28(32)20-21/h8-9,11-13,15-16,18-20,25-28,30-32H,10,14,17H2,1-7H3/b9-8+,12-11+,16-15+,21-20+,22-18-,23-19-,24-13+/t25-,26-,27+,28+,30+/m0/s1 YEYUXRUNTCBNSI-GNVMUULTSA-N 50520503 CHEMBL4471610 P2X purinoceptor 3 Homo sapiens 1310 ChEMBL 10.1021/acs.jmedchem.9b01887 10.7270/Q2NZ8C2N 31990540 Scheeff, S; Rivière, S; Ruiz, J; Abdelrahman, A; Schulz-Fincke, AC; Köse, M; Tiburcy, F; Wieczorek, H; Gütschow, M; Müller, CE; Menche, D Universit£t Bonn http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50520503 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50520503&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155535066 440729085 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51275408 CNC(=O)O[C@@H](CC(C)C)c1nc(cs1)[C@@H](O)[C@@H](C)\C=C\C=C(/C)[C@@H](OC)[C@@H](C)[C@H](O)\C=C\C(\C)=C/C(/C)=C\[C@H](C)[C@H](O)\C=C(/C)\C=C\CC(=O)OC InChI=1S/C42H64N2O8S/c1-26(2)21-37(52-42(49)43-10)41-44-34(25-53-41)39(48)30(6)16-14-17-31(7)40(51-12)33(9)35(45)20-19-28(4)22-29(5)23-32(8)36(46)24-27(3)15-13-18-38(47)50-11/h13-17,19-20,22-26,30,32-33,35-37,39-40,45-46,48H,18,21H2,1-12H3,(H,43,49)/b15-13+,16-14+,20-19+,27-24+,28-22-,29-23-,31-17+/t30-,32-,33-,35+,36+,37-,39-,40+/m0/s1 CHCVPROLISNQDZ-PJXSTYGASA-N 50520501 CHEMBL4549217 P2X purinoceptor 3 Homo sapiens >10000 ChEMBL 10.1021/acs.jmedchem.9b01887 10.7270/Q2NZ8C2N 31990540 Scheeff, S; Rivière, S; Ruiz, J; Abdelrahman, A; Schulz-Fincke, AC; Köse, M; Tiburcy, F; Wieczorek, H; Gütschow, M; Müller, CE; Menche, D Universit£t Bonn http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50520501 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50520501&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155549377 440729083 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51275409 CNC(=O)O[C@@H](CC(C)C)c1nc(cs1)[C@H]1OC(=O)C\C=C\C(\C)=C\[C@@H](O)[C@@H](C)\C=C(\C)/C=C(/C)\C=C\[C@@H](O)[C@H](C)[C@H](OC)\C(C)=C\C=C\[C@@H]1C InChI=1S/C41H60N2O7S/c1-25(2)20-36(49-41(47)42-10)40-43-33(24-51-40)39-30(7)16-13-15-29(6)38(48-11)32(9)34(44)19-18-27(4)21-28(5)22-31(8)35(45)23-26(3)14-12-17-37(46)50-39/h12-16,18-19,21-25,30-32,34-36,38-39,44-45H,17,20H2,1-11H3,(H,42,47)/b14-12+,16-13+,19-18+,26-23+,27-21-,28-22-,29-15+/t30-,31-,32-,34+,35+,36-,38+,39-/m0/s1 WRJITTKUXGEQBF-KJKBHKFMSA-N 50483929 Archazolid F::CHEBI:67525 P2X purinoceptor 3 Homo sapiens 438 ChEMBL 10.1021/acs.jmedchem.9b01887 10.7270/Q2NZ8C2N 31990540 Scheeff, S; Rivière, S; Ruiz, J; Abdelrahman, A; Schulz-Fincke, AC; Köse, M; Tiburcy, F; Wieczorek, H; Gütschow, M; Müller, CE; Menche, D Universit£t Bonn http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50483929 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50483929&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 53262865 433951194 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51275411 CO[C@H]1\C=C\C=C(C)\C[C@H](C)[C@H](O)[C@H](C)\C=C(/C)\C=C(OC)\C(=O)O[C@@H]1[C@@H](C)[C@@H](O)[C@H](C)[C@@]1(O)C[C@@H](O)[C@H](C)[C@H](O1)C(C)C InChI=1S/C35H58O9/c1-19(2)32-24(7)27(36)18-35(40,44-32)26(9)31(38)25(8)33-28(41-10)14-12-13-20(3)15-22(5)30(37)23(6)16-21(4)17-29(42-11)34(39)43-33/h12-14,16-17,19,22-28,30-33,36-38,40H,15,18H2,1-11H3/b14-12+,20-13+,21-16+,29-17-/t22-,23+,24-,25-,26-,27+,28-,30-,31+,32+,33+,35+/m0/s1 XDHNQDDQEHDUTM-JQWOJBOSSA-N 50064186 (3Z,5E,7R,8S,9S,11E,13E,15S,16R)-16-{(2S,3R,4S)-4-[(2R,4R,5S,6R)-2,4-dihydroxy-6-isopropyl-5-methyltetrahydro-2H-pyran-2-yl]-3-hydroxypentan-2-yl}-8-hydroxy-3,15-dimethoxy-5,7,9,11-tetramethyloxacyclohexadeca-3,5,11,13-tetraen-2-one::CHEMBL290814::bafilomycin A1 P2X purinoceptor 3 Homo sapiens 755 ChEMBL 10.1021/acs.jmedchem.9b01887 10.7270/Q2NZ8C2N 31990540 Scheeff, S; Rivière, S; Ruiz, J; Abdelrahman, A; Schulz-Fincke, AC; Köse, M; Tiburcy, F; Wieczorek, H; Gütschow, M; Müller, CE; Menche, D Universit£t Bonn http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50064186 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50064186&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 6436223 103959252 22689 CHEMBL290814 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51325450 CN(C)c1ccc(cc1)C(=O)N1CCC(CC1)n1cncc1-c1ccc(OS(=O)(=O)c2cccc(c2)C(=O)NC2CC2)cc1 InChI=1S/C33H35N5O5S/c1-36(2)27-12-6-24(7-13-27)33(40)37-18-16-28(17-19-37)38-22-34-21-31(38)23-8-14-29(15-9-23)43-44(41,42)30-5-3-4-25(20-30)32(39)35-26-10-11-26/h3-9,12-15,20-22,26,28H,10-11,16-19H2,1-2H3,(H,35,39) MUCFYQFETABRSU-UHFFFAOYSA-N 50536370 CHEMBL4582650 P2X purinoceptor 3 Homo sapiens 910 ChEMBL 10.1021/acs.jmedchem.5b01690 10.7270/Q2BC431Q 27427902 Park, JH; Williams, DR; Lee, JH; Lee, SD; Lee, JH; Ko, H; Lee, GE; Kim, S; Lee, JM; Abdelrahman, A; Müller, CE; Jung, DW; Kim, YC Gwangju Institute of Science and Technology (GIST) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50536370 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50536370&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 142737932 440827194 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51325493 FC(F)(F)c1cc(ccc1Cl)C(=O)N1CCC(CC1)N1C(Cc2ccc(OS(=O)(=O)c3cccc4cnccc34)cc2)C(=O)NC1=O InChI=1S/C32H26ClF3N4O6S/c33-26-9-6-20(17-25(26)32(34,35)36)30(42)39-14-11-22(12-15-39)40-27(29(41)38-31(40)43)16-19-4-7-23(8-5-19)46-47(44,45)28-3-1-2-21-18-37-13-10-24(21)28/h1-10,13,17-18,22,27H,11-12,14-16H2,(H,38,41,43) NTIPPLUXKZVJHM-UHFFFAOYSA-N 50075467 CHEMBL3415342 P2X purinoceptor 3 Homo sapiens 600 ChEMBL 10.1021/acs.jmedchem.5b01690 10.7270/Q2BC431Q 27427902 Park, JH; Williams, DR; Lee, JH; Lee, SD; Lee, JH; Ko, H; Lee, GE; Kim, S; Lee, JM; Abdelrahman, A; Müller, CE; Jung, DW; Kim, YC Gwangju Institute of Science and Technology (GIST) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50075467 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50075467&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118733194 103968567 CHEMBL3415342 ZINC36080060 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51325494 CN(C)c1ccc(cc1)C(=O)N1CCN(CC1)c1cc(=O)[nH]c(=O)n1Cc1ccc(OS(=O)(=O)c2cccc3cnccc23)cc1 InChI=1S/C33H32N6O6S/c1-36(2)26-10-8-24(9-11-26)32(41)38-18-16-37(17-19-38)31-20-30(40)35-33(42)39(31)22-23-6-12-27(13-7-23)45-46(43,44)29-5-3-4-25-21-34-15-14-28(25)29/h3-15,20-21H,16-19,22H2,1-2H3,(H,35,40,42) YMBFNIIQUUIOKW-UHFFFAOYSA-N 50536393 CHEMBL4561852 P2X purinoceptor 3 Homo sapiens 2660 ChEMBL 10.1021/acs.jmedchem.5b01690 10.7270/Q2BC431Q 27427902 Park, JH; Williams, DR; Lee, JH; Lee, SD; Lee, JH; Ko, H; Lee, GE; Kim, S; Lee, JM; Abdelrahman, A; Müller, CE; Jung, DW; Kim, YC Gwangju Institute of Science and Technology (GIST) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50536393 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50536393&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 142737950 440827217 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51325495 [Na+].[Na+].[Na+].[Na+].[O-]S(=O)(=O)c1ccc(NC(=O)c2cc(NC(=O)Nc3cc(cc(c3)C(=O)Nc3ccc(cc3)S([O-])(=O)=O)C(=O)Nc3ccc(cc3)S([O-])(=O)=O)cc(c2)C(=O)Nc2ccc(cc2)S([O-])(=O)=O)cc1 InChI=1S/C41H32N6O17S4/c48-37(42-27-1-9-33(10-2-27)65(53,54)55)23-17-24(38(49)43-28-3-11-34(12-4-28)66(56,57)58)20-31(19-23)46-41(52)47-32-21-25(39(50)44-29-5-13-35(14-6-29)67(59,60)61)18-26(22-32)40(51)45-30-7-15-36(16-8-30)68(62,63)64/h1-22H,(H,42,48)(H,43,49)(H,44,50)(H,45,51)(H2,46,47,52)(H,53,54,55)(H,56,57,58)(H,59,60,61)(H,62,63,64)/p-4 XLJCHJYKCSKQLL-UHFFFAOYSA-J 50370297 CHEMBL4160315 P2X purinoceptor 3 Homo sapiens 1580 ChEMBL 10.1021/acs.jmedchem.5b01690 10.7270/Q2BC431Q 27427902 Park, JH; Williams, DR; Lee, JH; Lee, SD; Lee, JH; Ko, H; Lee, GE; Kim, S; Lee, JM; Abdelrahman, A; Müller, CE; Jung, DW; Kim, YC Gwangju Institute of Science and Technology (GIST) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50370297 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50370297&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 16066783 160849399 ZINC48998601 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51325528 CN(C)c1ccc(cc1)C(=O)N1CCC(CC1)n1cncc1-c1ccc(OS(=O)(=O)c2cccc3cnccc23)cc1 InChI=1S/C32H31N5O4S/c1-35(2)26-10-6-24(7-11-26)32(38)36-18-15-27(16-19-36)37-22-34-21-30(37)23-8-12-28(13-9-23)41-42(39,40)31-5-3-4-25-20-33-17-14-29(25)31/h3-14,17,20-22,27H,15-16,18-19H2,1-2H3 HZABZKYZDQPWMV-UHFFFAOYSA-N 50370300 CHEMBL4165149 P2X purinoceptor 3 Homo sapiens 800 ChEMBL 10.1021/acs.jmedchem.5b01690 10.7270/Q2BC431Q 27427902 Park, JH; Williams, DR; Lee, JH; Lee, SD; Lee, JH; Ko, H; Lee, GE; Kim, S; Lee, JM; Abdelrahman, A; Müller, CE; Jung, DW; Kim, YC Gwangju Institute of Science and Technology (GIST) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50370300 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50370300&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 142737955 160849402 ZINC48999802 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51311171 Cc1cc(on1)-c1ccc(cc1)N1C(C(C(=O)C(C)(C)C)=C(O)C1=O)c1ccccc1OCCO InChI=1S/C27H28N2O6/c1-16-15-21(35-28-16)17-9-11-18(12-10-17)29-23(19-7-5-6-8-20(19)34-14-13-30)22(24(31)26(29)33)25(32)27(2,3)4/h5-12,15,23,30-31H,13-14H2,1-4H3 UICZHYAYPKFHQS-UHFFFAOYSA-N 50532061 CHEMBL4459785 P2X purinoceptor 3 Homo sapiens 999 ChEMBL 10.1016/j.bmcl.2019.01.039 10.7270/Q23F4T48 30728111 Tobinaga, H; Kameyama, T; Asahi, K; Horiguchi, T; Oohara, M; Tada, Y; Fuchino, K; Jikihara, S; Endoh, T; Kurihara, N; Kanda, Y; Ogawa, M; Tamura, N; Yagi, S; Taniguchi, E; Takahara, Y; Shimada, S; Takeyama, C; Yamamoto, S; Shinohara, S; Kai, H Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50532061 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50532061&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58366064 440740643 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315736 COc1ccc(OC)c(CCn2cnc3sc4C[C@@H](CCc4c3c2=O)C(=O)N(C)C)c1 InChI=1S/C23H27N3O4S/c1-25(2)22(27)15-5-7-17-19(12-15)31-21-20(17)23(28)26(13-24-21)10-9-14-11-16(29-3)6-8-18(14)30-4/h6,8,11,13,15H,5,7,9-10,12H2,1-4H3/t15-/m1/s1 FZCDZTJYZBKDBO-OAHLLOKOSA-N 50532966 CHEMBL4464204 P2X purinoceptor 3 Homo sapiens 668 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50532966 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50532966&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155530320 440741548 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315737 COc1ccccc1CCn1cnc2sc3CN(CCc3c2c1=O)S(=O)(=O)N(C)C InChI=1S/C20H24N4O4S2/c1-22(2)30(26,27)24-11-9-15-17(12-24)29-19-18(15)20(25)23(13-21-19)10-8-14-6-4-5-7-16(14)28-3/h4-7,13H,8-12H2,1-3H3 POPFQBKOBJMISL-UHFFFAOYSA-N 50532967 CHEMBL4454932 P2X purinoceptor 3 Homo sapiens 440 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50532967 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50532967&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155524156 440741549 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315738 COc1ccc(CCn2cnc3sc4CN(CCc4c3c2=O)C(=O)OC(C)(C)C)c(OC)c1 InChI=1S/C24H29N3O5S/c1-24(2,3)32-23(29)26-11-9-17-19(13-26)33-21-20(17)22(28)27(14-25-21)10-8-15-6-7-16(30-4)12-18(15)31-5/h6-7,12,14H,8-11,13H2,1-5H3 ORQIPWOBFYNSNO-UHFFFAOYSA-N 50532968 CHEMBL4465662 P2X purinoceptor 3 Homo sapiens 580 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50532968 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50532968&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155531083 440741550 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315739 COc1nc(CCn2cnc3sc4CN(CCc4c3c2=O)S(=O)(=O)N(C)C)c(C)c(OC)n1 InChI=1S/C20H26N6O5S2/c1-12-14(22-20(31-5)23-17(12)30-4)7-8-25-11-21-18-16(19(25)27)13-6-9-26(10-15(13)32-18)33(28,29)24(2)3/h11H,6-10H2,1-5H3 VXASZNAWUKYDHF-UHFFFAOYSA-N 50532969 CHEMBL4529205 P2X purinoceptor 3 Homo sapiens 7500 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50532969 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50532969&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155545366 440741551 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315740 COc1ccc(OC)c(CCn2cnc3sc4CN(CCc4c3c2=O)C(=O)C2CC2)c1 InChI=1S/C23H25N3O4S/c1-29-16-5-6-18(30-2)15(11-16)7-9-26-13-24-21-20(23(26)28)17-8-10-25(12-19(17)31-21)22(27)14-3-4-14/h5-6,11,13-14H,3-4,7-10,12H2,1-2H3 CBJLMMZJKTZZCR-UHFFFAOYSA-N 50532970 CHEMBL4544380 P2X purinoceptor 3 Homo sapiens 15 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50532970 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50532970&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155552819 440741552 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315741 COc1cc(CCn2cnc3sc4CN(CCc4c3c2=O)C(=O)CN)cc(OC)c1 InChI=1S/C21H24N4O4S/c1-28-14-7-13(8-15(9-14)29-2)3-5-25-12-23-20-19(21(25)27)16-4-6-24(18(26)10-22)11-17(16)30-20/h7-9,12H,3-6,10-11,22H2,1-2H3 COFYQWLFXKOQHH-UHFFFAOYSA-N 50532971 CHEMBL4448180 P2X purinoceptor 3 Homo sapiens 1400 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50532971 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50532971&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155519441 440741553 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315742 COc1ccccc1CCCn1cnc2sc3CN(CCc3c2c1=O)C(=O)OC(C)(C)C InChI=1S/C24H29N3O4S/c1-24(2,3)31-23(29)26-13-11-17-19(14-26)32-21-20(17)22(28)27(15-25-21)12-7-9-16-8-5-6-10-18(16)30-4/h5-6,8,10,15H,7,9,11-14H2,1-4H3 INHCHXDLEAVPGY-UHFFFAOYSA-N 50532972 CHEMBL4458523 P2X purinoceptor 3 Homo sapiens 7500 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50532972 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50532972&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155526369 440741554 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315743 COc1ccc(OC)c(CCn2cnc3sc4CNCCc4c3c2=O)c1 InChI=1S/C19H21N3O3S/c1-24-13-3-4-15(25-2)12(9-13)6-8-22-11-21-18-17(19(22)23)14-5-7-20-10-16(14)26-18/h3-4,9,11,20H,5-8,10H2,1-2H3 CJNTWGXQXBLUGI-UHFFFAOYSA-N 50532973 CHEMBL4524946 P2X purinoceptor 3 Homo sapiens 11200 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50532973 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50532973&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155538734 440741555 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315744 COc1ccc(OC)c(CCn2cnc3sc4CNCCc4c3c2=O)c1 InChI=1S/C19H21N3O3S/c1-24-13-3-4-15(25-2)12(9-13)6-8-22-11-21-18-17(19(22)23)14-5-7-20-10-16(14)26-18/h3-4,9,11,20H,5-8,10H2,1-2H3 CJNTWGXQXBLUGI-UHFFFAOYSA-N 50532973 CHEMBL4524946 P2X purinoceptor 3 Homo sapiens 11200 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50532973 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50532973&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155538734 440741555 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315745 COc1nc(CCn2cnc3sc4CN(CCc4c3c2=O)S(=O)(=O)N(C)C)c(C)c(OC)n1 InChI=1S/C20H26N6O5S2/c1-12-14(22-20(31-5)23-17(12)30-4)7-8-25-11-21-18-16(19(25)27)13-6-9-26(10-15(13)32-18)33(28,29)24(2)3/h11H,6-10H2,1-5H3 VXASZNAWUKYDHF-UHFFFAOYSA-N 50532969 CHEMBL4529205 P2X purinoceptor 3 Homo sapiens 7500 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50532969 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50532969&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155545366 440741551 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315746 COc1ccc(OC)c(CCn2cnc3sc4CN(CCc4c3c2=O)C(=O)C2CC2)c1 InChI=1S/C23H25N3O4S/c1-29-16-5-6-18(30-2)15(11-16)7-9-26-13-24-21-20(23(26)28)17-8-10-25(12-19(17)31-21)22(27)14-3-4-14/h5-6,11,13-14H,3-4,7-10,12H2,1-2H3 CBJLMMZJKTZZCR-UHFFFAOYSA-N 50532970 CHEMBL4544380 P2X purinoceptor 3 Homo sapiens 15 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50532970 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50532970&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155552819 440741552 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315747 COc1cc(CCn2cnc3sc4CN(CCc4c3c2=O)C(=O)CN)cc(OC)c1 InChI=1S/C21H24N4O4S/c1-28-14-7-13(8-15(9-14)29-2)3-5-25-12-23-20-19(21(25)27)16-4-6-24(18(26)10-22)11-17(16)30-20/h7-9,12H,3-6,10-11,22H2,1-2H3 COFYQWLFXKOQHH-UHFFFAOYSA-N 50532971 CHEMBL4448180 P2X purinoceptor 3 Homo sapiens 1400 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50532971 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50532971&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155519441 440741553 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315748 COc1ccc(OC)c(CCn2cnc3sc4C[C@@H](CCc4c3c2=O)C(=O)N(C)C)c1 InChI=1S/C23H27N3O4S/c1-25(2)22(27)15-5-7-17-19(12-15)31-21-20(17)23(28)26(13-24-21)10-9-14-11-16(29-3)6-8-18(14)30-4/h6,8,11,13,15H,5,7,9-10,12H2,1-4H3/t15-/m1/s1 FZCDZTJYZBKDBO-OAHLLOKOSA-N 50532966 CHEMBL4464204 P2X purinoceptor 3 Homo sapiens 668 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50532966 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50532966&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155530320 440741548 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315749 COc1ccccc1CCn1cnc2sc3CN(CCc3c2c1=O)S(=O)(=O)N1CCCC1 InChI=1S/C22H26N4O4S2/c1-30-18-7-3-2-6-16(18)8-12-24-15-23-21-20(22(24)27)17-9-13-26(14-19(17)31-21)32(28,29)25-10-4-5-11-25/h2-3,6-7,15H,4-5,8-14H2,1H3 RRLOGTRSEFIJIN-UHFFFAOYSA-N 50532974 CHEMBL4516592 P2X purinoceptor 3 Homo sapiens 720 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50532974 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50532974&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155540285 440741556 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315750 COc1ccc(CCn2cnc3sc4CN(CCc4c3c2=O)C(=O)OC(C)(C)C)c(OC)c1 InChI=1S/C24H29N3O5S/c1-24(2,3)32-23(29)26-11-9-17-19(13-26)33-21-20(17)22(28)27(14-25-21)10-8-15-6-7-16(30-4)12-18(15)31-5/h6-7,12,14H,8-11,13H2,1-5H3 ORQIPWOBFYNSNO-UHFFFAOYSA-N 50532968 CHEMBL4465662 P2X purinoceptor 3 Homo sapiens 580 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50532968 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50532968&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155531083 440741550 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315751 COc1ccccc1CCn1cnc2sc3CN(CCc3c2c1=O)C(=O)OC(C)(C)C InChI=1S/C23H27N3O4S/c1-23(2,3)30-22(28)25-12-10-16-18(13-25)31-20-19(16)21(27)26(14-24-20)11-9-15-7-5-6-8-17(15)29-4/h5-8,14H,9-13H2,1-4H3 LOIJPBFYQBYKEK-UHFFFAOYSA-N 50532975 CHEMBL4567453 P2X purinoceptor 3 Homo sapiens 1300 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50532975 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50532975&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155550493 440741557 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315752 COc1ccccc1CCn1cnc2sc3CN(CCc3c2c1=O)S(=O)(=O)N1CCCCC1 InChI=1S/C23H28N4O4S2/c1-31-19-8-4-3-7-17(19)9-13-25-16-24-22-21(23(25)28)18-10-14-27(15-20(18)32-22)33(29,30)26-11-5-2-6-12-26/h3-4,7-8,16H,2,5-6,9-15H2,1H3 KBJFLNHUSYJTSU-UHFFFAOYSA-N 50532976 CHEMBL4549675 P2X purinoceptor 3 Homo sapiens 850 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50532976 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50532976&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155543528 440741558 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315753 COc1ccccc1CCn1cnc2sc3CN(CCc3c2c1=O)S(=O)(=O)c1ccccc1 InChI=1S/C24H23N3O4S2/c1-31-20-10-6-5-7-17(20)11-13-26-16-25-23-22(24(26)28)19-12-14-27(15-21(19)32-23)33(29,30)18-8-3-2-4-9-18/h2-10,16H,11-15H2,1H3 BTJZESDMZLYDEY-UHFFFAOYSA-N 50532977 CHEMBL4531994 P2X purinoceptor 3 Homo sapiens 810 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50532977 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50532977&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 42666540 440741559 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315754 COc1ccccc1CCn1cnc2sc3CN(CCc3c2c1=O)C(=O)N1CCOCC1 InChI=1S/C23H26N4O4S/c1-30-18-5-3-2-4-16(18)6-8-27-15-24-21-20(22(27)28)17-7-9-26(14-19(17)32-21)23(29)25-10-12-31-13-11-25/h2-5,15H,6-14H2,1H3 UIXFHCMVAQPTDF-UHFFFAOYSA-N 50532978 CHEMBL4589553 P2X purinoceptor 3 Homo sapiens 3800 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50532978 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50532978&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155567668 440741560 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315755 COc1ccccc1CCn1cnc2sc3CN(CCc3c2c1=O)C(=O)N(C)C InChI=1S/C21H24N4O3S/c1-23(2)21(27)24-11-9-15-17(12-24)29-19-18(15)20(26)25(13-22-19)10-8-14-6-4-5-7-16(14)28-3/h4-7,13H,8-12H2,1-3H3 INGYNNDDJIOBJA-UHFFFAOYSA-N 50532979 CHEMBL4439753 P2X purinoceptor 3 Homo sapiens 1300 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50532979 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50532979&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 42795648 440741561 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315756 COc1ccccc1CCn1cnc2sc3CN(CCc3c2c1=O)C(=O)NC(C)(C)C InChI=1S/C23H28N4O3S/c1-23(2,3)25-22(29)26-12-10-16-18(13-26)31-20-19(16)21(28)27(14-24-20)11-9-15-7-5-6-8-17(15)30-4/h5-8,14H,9-13H2,1-4H3,(H,25,29) HGJQSFLUTRUQJU-UHFFFAOYSA-N 50532980 CHEMBL4515211 P2X purinoceptor 3 Homo sapiens 7500 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50532980 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50532980&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 42795663 440741562 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315757 COc1cc(CCn2cnc3sc4CN(CCc4c3c2=O)C(=O)OC(C)(C)C)cc(OC)c1 InChI=1S/C24H29N3O5S/c1-24(2,3)32-23(29)26-9-7-18-19(13-26)33-21-20(18)22(28)27(14-25-21)8-6-15-10-16(30-4)12-17(11-15)31-5/h10-12,14H,6-9,13H2,1-5H3 KYTBJMIMHRRYRW-UHFFFAOYSA-N 50532981 CHEMBL4471519 P2X purinoceptor 3 Homo sapiens 390 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50532981 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50532981&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155535354 440741563 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315758 COc1ccc(CCn2cnc3sc4CN(CCc4c3c2=O)C(=O)OC(C)(C)C)cc1OC InChI=1S/C24H29N3O5S/c1-24(2,3)32-23(29)26-11-9-16-19(13-26)33-21-20(16)22(28)27(14-25-21)10-8-15-6-7-17(30-4)18(12-15)31-5/h6-7,12,14H,8-11,13H2,1-5H3 OSMFJRFWSDTZKZ-UHFFFAOYSA-N 50532982 CHEMBL4560167 P2X purinoceptor 3 Homo sapiens 3700 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50532982 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50532982&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155558639 440741564 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315759 COc1ccc(CCn2cnc3sc4CN(CCc4c3c2=O)C(=O)OC(C)(C)C)cc1 InChI=1S/C23H27N3O4S/c1-23(2,3)30-22(28)25-12-10-17-18(13-25)31-20-19(17)21(27)26(14-24-20)11-9-15-5-7-16(29-4)8-6-15/h5-8,14H,9-13H2,1-4H3 ZPLPMPLPZHYFAM-UHFFFAOYSA-N 50532983 CHEMBL4440709 P2X purinoceptor 3 Homo sapiens 7500 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50532983 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50532983&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155514869 440741565 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315760 CC(C)(C)OC(=O)N1CCc2c(C1)sc1ncn(CCc3ccccc3F)c(=O)c21 InChI=1S/C22H24FN3O3S/c1-22(2,3)29-21(28)25-11-9-15-17(12-25)30-19-18(15)20(27)26(13-24-19)10-8-14-6-4-5-7-16(14)23/h4-7,13H,8-12H2,1-3H3 VAFSGKMNCAMINP-UHFFFAOYSA-N 50532984 CHEMBL4469946 P2X purinoceptor 3 Homo sapiens 5000 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50532984 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50532984&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155534154 440741566 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51311174 CC(C)(C)C(=O)C1=C(O)C(=O)N(C1c1ccccc1OCC(O)=O)c1ccc(cc1)-c1ccsc1 InChI=1S/C27H25NO6S/c1-27(2,3)25(32)22-23(19-6-4-5-7-20(19)34-14-21(29)30)28(26(33)24(22)31)18-10-8-16(9-11-18)17-12-13-35-15-17/h4-13,15,23,31H,14H2,1-3H3,(H,29,30) LTOPYZFRLCROFQ-UHFFFAOYSA-N 50532064 CHEMBL4445659 P2X purinoceptor 3 Homo sapiens 74 ChEMBL 10.1016/j.bmcl.2019.01.039 10.7270/Q23F4T48 30728111 Tobinaga, H; Kameyama, T; Asahi, K; Horiguchi, T; Oohara, M; Tada, Y; Fuchino, K; Jikihara, S; Endoh, T; Kurihara, N; Kanda, Y; Ogawa, M; Tamura, N; Yagi, S; Taniguchi, E; Takahara, Y; Shimada, S; Takeyama, C; Yamamoto, S; Shinohara, S; Kai, H Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50532064 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50532064&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365704 440740646 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51311175 CCC(CC)C1N(C(=O)C(O)=C1C(=O)c1ccc(OC)cc1)c1ccc(cc1)-c1ccon1 InChI=1S/C26H26N2O5/c1-4-16(5-2)23-22(24(29)18-8-12-20(32-3)13-9-18)25(30)26(31)28(23)19-10-6-17(7-11-19)21-14-15-33-27-21/h6-16,23,30H,4-5H2,1-3H3 OSYJTEVIPYRGNR-UHFFFAOYSA-N 50532065 CHEMBL4439493 P2X purinoceptor 3 Homo sapiens 10.0 ChEMBL 10.1016/j.bmcl.2019.01.039 10.7270/Q23F4T48 30728111 Tobinaga, H; Kameyama, T; Asahi, K; Horiguchi, T; Oohara, M; Tada, Y; Fuchino, K; Jikihara, S; Endoh, T; Kurihara, N; Kanda, Y; Ogawa, M; Tamura, N; Yagi, S; Taniguchi, E; Takahara, Y; Shimada, S; Takeyama, C; Yamamoto, S; Shinohara, S; Kai, H Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50532065 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50532065&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 25097210 440740647 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51311179 COc1ccccc1C1N(C(=O)C(O)=C1C(=O)C(C)(C)C)c1ccc(cc1)-c1ccon1 InChI=1S/C25H24N2O5/c1-25(2,3)23(29)20-21(17-7-5-6-8-19(17)31-4)27(24(30)22(20)28)16-11-9-15(10-12-16)18-13-14-32-26-18/h5-14,21,28H,1-4H3 MLRLUDWLRDYPCT-UHFFFAOYSA-N 50532069 CHEMBL4444359 P2X purinoceptor 3 Homo sapiens 553 ChEMBL 10.1016/j.bmcl.2019.01.039 10.7270/Q23F4T48 30728111 Tobinaga, H; Kameyama, T; Asahi, K; Horiguchi, T; Oohara, M; Tada, Y; Fuchino, K; Jikihara, S; Endoh, T; Kurihara, N; Kanda, Y; Ogawa, M; Tamura, N; Yagi, S; Taniguchi, E; Takahara, Y; Shimada, S; Takeyama, C; Yamamoto, S; Shinohara, S; Kai, H Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50532069 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50532069&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 59447778 440740651 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51311180 CC(C)(C)C(=O)C1=C(O)C(=O)N(C1c1ccccc1OCCO)c1ccc(cc1)-c1ccsc1 InChI=1S/C27H27NO5S/c1-27(2,3)25(31)22-23(20-6-4-5-7-21(20)33-14-13-29)28(26(32)24(22)30)19-10-8-17(9-11-19)18-12-15-34-16-18/h4-12,15-16,23,29-30H,13-14H2,1-3H3 DGMADNJBABYWES-UHFFFAOYSA-N 50532070 CHEMBL4466252 P2X purinoceptor 3 Homo sapiens 13 ChEMBL 10.1016/j.bmcl.2019.01.039 10.7270/Q23F4T48 30728111 Tobinaga, H; Kameyama, T; Asahi, K; Horiguchi, T; Oohara, M; Tada, Y; Fuchino, K; Jikihara, S; Endoh, T; Kurihara, N; Kanda, Y; Ogawa, M; Tamura, N; Yagi, S; Taniguchi, E; Takahara, Y; Shimada, S; Takeyama, C; Yamamoto, S; Shinohara, S; Kai, H Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50532070 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50532070&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365867 440740652 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51311181 OCc1ccc(cc1)C(=O)C1=C(O)C(=O)N(C1C1CCCCC1)c1ccc(cc1)-c1ccon1 InChI=1S/C27H26N2O5/c30-16-17-6-8-20(9-7-17)25(31)23-24(19-4-2-1-3-5-19)29(27(33)26(23)32)21-12-10-18(11-13-21)22-14-15-34-28-22/h6-15,19,24,30,32H,1-5,16H2 SVOUFIADKRHQDI-UHFFFAOYSA-N 50532071 CHEMBL4585133 P2X purinoceptor 3 Homo sapiens 52 ChEMBL 10.1016/j.bmcl.2019.01.039 10.7270/Q23F4T48 30728111 Tobinaga, H; Kameyama, T; Asahi, K; Horiguchi, T; Oohara, M; Tada, Y; Fuchino, K; Jikihara, S; Endoh, T; Kurihara, N; Kanda, Y; Ogawa, M; Tamura, N; Yagi, S; Taniguchi, E; Takahara, Y; Shimada, S; Takeyama, C; Yamamoto, S; Shinohara, S; Kai, H Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50532071 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50532071&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58045231 440740653 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51311197 CC(C)(C)C(=O)C1=C(O)C(=O)N(C1c1ccccc1OCCO)c1ccc(cc1)-c1ccon1 InChI=1S/C26H26N2O6/c1-26(2,3)24(31)21-22(18-6-4-5-7-20(18)33-15-13-29)28(25(32)23(21)30)17-10-8-16(9-11-17)19-12-14-34-27-19/h4-12,14,22,29-30H,13,15H2,1-3H3 IUCLLEZQKXRIJZ-UHFFFAOYSA-N 50532073 CHEMBL4565775 P2X purinoceptor 3 Homo sapiens 82 ChEMBL 10.1016/j.bmcl.2019.01.039 10.7270/Q23F4T48 30728111 Tobinaga, H; Kameyama, T; Asahi, K; Horiguchi, T; Oohara, M; Tada, Y; Fuchino, K; Jikihara, S; Endoh, T; Kurihara, N; Kanda, Y; Ogawa, M; Tamura, N; Yagi, S; Taniguchi, E; Takahara, Y; Shimada, S; Takeyama, C; Yamamoto, S; Shinohara, S; Kai, H Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50532073 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50532073&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365945 440740655 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51311198 Cc1noc(n1)-c1ccc(cc1)N1C(C(C(=O)C(C)(C)C)=C(O)C1=O)c1ccccc1OCCO InChI=1S/C26H27N3O6/c1-15-27-24(35-28-15)16-9-11-17(12-10-16)29-21(18-7-5-6-8-19(18)34-14-13-30)20(22(31)25(29)33)23(32)26(2,3)4/h5-12,21,30-31H,13-14H2,1-4H3 UEVCTGRYUOKZBF-UHFFFAOYSA-N 50532067 CHEMBL4526549 P2X purinoceptor 3 Homo sapiens 1089 ChEMBL 10.1016/j.bmcl.2019.01.039 10.7270/Q23F4T48 30728111 Tobinaga, H; Kameyama, T; Asahi, K; Horiguchi, T; Oohara, M; Tada, Y; Fuchino, K; Jikihara, S; Endoh, T; Kurihara, N; Kanda, Y; Ogawa, M; Tamura, N; Yagi, S; Taniguchi, E; Takahara, Y; Shimada, S; Takeyama, C; Yamamoto, S; Shinohara, S; Kai, H Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50532067 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50532067&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365941 440740649 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51311199 CC(C)(C)C(=O)C1=C(O)C(=O)N(C1c1ccccc1OCCO)c1ccc(cc1)-c1cccs1 InChI=1S/C27H27NO5S/c1-27(2,3)25(31)22-23(19-7-4-5-8-20(19)33-15-14-29)28(26(32)24(22)30)18-12-10-17(11-13-18)21-9-6-16-34-21/h4-13,16,23,29-30H,14-15H2,1-3H3 KXPWMTRPMPVERN-UHFFFAOYSA-N 50532063 CHEMBL4465467 P2X purinoceptor 3 Homo sapiens 16 ChEMBL 10.1016/j.bmcl.2019.01.039 10.7270/Q23F4T48 30728111 Tobinaga, H; Kameyama, T; Asahi, K; Horiguchi, T; Oohara, M; Tada, Y; Fuchino, K; Jikihara, S; Endoh, T; Kurihara, N; Kanda, Y; Ogawa, M; Tamura, N; Yagi, S; Taniguchi, E; Takahara, Y; Shimada, S; Takeyama, C; Yamamoto, S; Shinohara, S; Kai, H Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50532063 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50532063&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365828 440740645 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51311200 COc1ccccc1C1N(C(=O)C(O)=C1C(=O)C(C)(C)C)c1ccc(cc1)-c1ccsc1 InChI=1S/C26H25NO4S/c1-26(2,3)24(29)21-22(19-7-5-6-8-20(19)31-4)27(25(30)23(21)28)18-11-9-16(10-12-18)17-13-14-32-15-17/h5-15,22,28H,1-4H3 WVBPRJPQPGZBKU-UHFFFAOYSA-N 50532076 CHEMBL4457637 P2X purinoceptor 3 Homo sapiens 16 ChEMBL 10.1016/j.bmcl.2019.01.039 10.7270/Q23F4T48 30728111 Tobinaga, H; Kameyama, T; Asahi, K; Horiguchi, T; Oohara, M; Tada, Y; Fuchino, K; Jikihara, S; Endoh, T; Kurihara, N; Kanda, Y; Ogawa, M; Tamura, N; Yagi, S; Taniguchi, E; Takahara, Y; Shimada, S; Takeyama, C; Yamamoto, S; Shinohara, S; Kai, H Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50532076 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50532076&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365345 440740658 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51311201 COCCOc1ccccc1C1N(C(=O)C(O)=C1C(=O)C(C)(C)C)c1ccc(cc1)-c1ccsc1 InChI=1S/C28H29NO5S/c1-28(2,3)26(31)23-24(21-7-5-6-8-22(21)34-15-14-33-4)29(27(32)25(23)30)20-11-9-18(10-12-20)19-13-16-35-17-19/h5-13,16-17,24,30H,14-15H2,1-4H3 XWVXIHGMEYLOBZ-UHFFFAOYSA-N 50532072 CHEMBL4592312 P2X purinoceptor 3 Homo sapiens 11 ChEMBL 10.1016/j.bmcl.2019.01.039 10.7270/Q23F4T48 30728111 Tobinaga, H; Kameyama, T; Asahi, K; Horiguchi, T; Oohara, M; Tada, Y; Fuchino, K; Jikihara, S; Endoh, T; Kurihara, N; Kanda, Y; Ogawa, M; Tamura, N; Yagi, S; Taniguchi, E; Takahara, Y; Shimada, S; Takeyama, C; Yamamoto, S; Shinohara, S; Kai, H Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50532072 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50532072&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365813 440740654 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51311202 C[S+]([O-])CCOc1ccccc1C1N(C(=O)C(O)=C1C(=O)C(C)(C)C)c1ccc(cc1)-c1ccsc1 InChI=1S/C28H29NO5S2/c1-28(2,3)26(31)23-24(21-7-5-6-8-22(21)34-14-16-36(4)33)29(27(32)25(23)30)20-11-9-18(10-12-20)19-13-15-35-17-19/h5-13,15,17,24,30H,14,16H2,1-4H3 OFHDTCSYYVFYKS-UHFFFAOYSA-N 50532068 CHEMBL4459391 P2X purinoceptor 3 Homo sapiens 16 ChEMBL 10.1016/j.bmcl.2019.01.039 10.7270/Q23F4T48 30728111 Tobinaga, H; Kameyama, T; Asahi, K; Horiguchi, T; Oohara, M; Tada, Y; Fuchino, K; Jikihara, S; Endoh, T; Kurihara, N; Kanda, Y; Ogawa, M; Tamura, N; Yagi, S; Taniguchi, E; Takahara, Y; Shimada, S; Takeyama, C; Yamamoto, S; Shinohara, S; Kai, H Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50532068 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50532068&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365250 440740650 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51311203 CN(C)C(=O)COc1ccccc1C1N(C(=O)C(O)=C1C(=O)C(C)(C)C)c1ccc(cc1)-c1ccsc1 InChI=1S/C29H30N2O5S/c1-29(2,3)27(34)24-25(21-8-6-7-9-22(21)36-16-23(32)30(4)5)31(28(35)26(24)33)20-12-10-18(11-13-20)19-14-15-37-17-19/h6-15,17,25,33H,16H2,1-5H3 PCEMVTGQRJJGLZ-UHFFFAOYSA-N 50532077 CHEMBL4459015 P2X purinoceptor 3 Homo sapiens 73 ChEMBL 10.1016/j.bmcl.2019.01.039 10.7270/Q23F4T48 30728111 Tobinaga, H; Kameyama, T; Asahi, K; Horiguchi, T; Oohara, M; Tada, Y; Fuchino, K; Jikihara, S; Endoh, T; Kurihara, N; Kanda, Y; Ogawa, M; Tamura, N; Yagi, S; Taniguchi, E; Takahara, Y; Shimada, S; Takeyama, C; Yamamoto, S; Shinohara, S; Kai, H Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50532077 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50532077&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365744 440740659 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51311204 CC(C)C(=O)C1=C(O)C(=O)N(C1c1ccccc1OCC[S+](C)[O-])c1ccc(cc1)-c1ccsc1 InChI=1S/C27H27NO5S2/c1-17(2)25(29)23-24(21-6-4-5-7-22(21)33-13-15-35(3)32)28(27(31)26(23)30)20-10-8-18(9-11-20)19-12-14-34-16-19/h4-12,14,16-17,24,30H,13,15H2,1-3H3 WLLMHLXFTTYNGV-UHFFFAOYSA-N 50532078 CHEMBL4437131 P2X purinoceptor 3 Homo sapiens 13 ChEMBL 10.1016/j.bmcl.2019.01.039 10.7270/Q23F4T48 30728111 Tobinaga, H; Kameyama, T; Asahi, K; Horiguchi, T; Oohara, M; Tada, Y; Fuchino, K; Jikihara, S; Endoh, T; Kurihara, N; Kanda, Y; Ogawa, M; Tamura, N; Yagi, S; Taniguchi, E; Takahara, Y; Shimada, S; Takeyama, C; Yamamoto, S; Shinohara, S; Kai, H Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50532078 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50532078&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365527 440740660 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51311205 COc1ccc(cn1)C(=O)C1=C(O)C(=O)N(C1C1CCCCC1)c1ccc(cc1)-c1ccon1 InChI=1S/C26H25N3O5/c1-33-21-12-9-18(15-27-21)24(30)22-23(17-5-3-2-4-6-17)29(26(32)25(22)31)19-10-7-16(8-11-19)20-13-14-34-28-20/h7-15,17,23,31H,2-6H2,1H3 VINGOJRLECRAOW-UHFFFAOYSA-N 50532079 CHEMBL4458893 P2X purinoceptor 3 Homo sapiens 44 ChEMBL 10.1016/j.bmcl.2019.01.039 10.7270/Q23F4T48 30728111 Tobinaga, H; Kameyama, T; Asahi, K; Horiguchi, T; Oohara, M; Tada, Y; Fuchino, K; Jikihara, S; Endoh, T; Kurihara, N; Kanda, Y; Ogawa, M; Tamura, N; Yagi, S; Taniguchi, E; Takahara, Y; Shimada, S; Takeyama, C; Yamamoto, S; Shinohara, S; Kai, H Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50532079 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50532079&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58045105 440740661 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51311206 CNC(=O)c1ccc(cc1)C(=O)C1=C(O)C(=O)N(C1C1CCCCC1)c1ccc(cc1)-c1ccon1 InChI=1S/C28H27N3O5/c1-29-27(34)20-9-7-19(8-10-20)25(32)23-24(18-5-3-2-4-6-18)31(28(35)26(23)33)21-13-11-17(12-14-21)22-15-16-36-30-22/h7-16,18,24,33H,2-6H2,1H3,(H,29,34) OEAJFZCAPQQYPH-UHFFFAOYSA-N 50532080 CHEMBL4466162 P2X purinoceptor 3 Homo sapiens 11 ChEMBL 10.1016/j.bmcl.2019.01.039 10.7270/Q23F4T48 30728111 Tobinaga, H; Kameyama, T; Asahi, K; Horiguchi, T; Oohara, M; Tada, Y; Fuchino, K; Jikihara, S; Endoh, T; Kurihara, N; Kanda, Y; Ogawa, M; Tamura, N; Yagi, S; Taniguchi, E; Takahara, Y; Shimada, S; Takeyama, C; Yamamoto, S; Shinohara, S; Kai, H Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50532080 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50532080&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58044900 440740662 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51311207 COc1ccc(cc1)C(=O)C1=C(O)C(=O)N(C1C1CCCCC1)c1ccc(cc1)-c1ccon1 InChI=1S/C27H26N2O5/c1-33-21-13-9-19(10-14-21)25(30)23-24(18-5-3-2-4-6-18)29(27(32)26(23)31)20-11-7-17(8-12-20)22-15-16-34-28-22/h7-16,18,24,31H,2-6H2,1H3 VVVNQMHFXWAMBD-UHFFFAOYSA-N 50274365 CHEMBL4127637 P2X purinoceptor 3 Homo sapiens 25 ChEMBL 10.1016/j.bmcl.2019.01.039 10.7270/Q23F4T48 30728111 Tobinaga, H; Kameyama, T; Asahi, K; Horiguchi, T; Oohara, M; Tada, Y; Fuchino, K; Jikihara, S; Endoh, T; Kurihara, N; Kanda, Y; Ogawa, M; Tamura, N; Yagi, S; Taniguchi, E; Takahara, Y; Shimada, S; Takeyama, C; Yamamoto, S; Shinohara, S; Kai, H Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50274365 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50274365&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 145960885 405256876 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51311226 COc1ccc(cc1)C(=O)C1=C(O)C(=O)N(C1c1ccccc1OCCO)c1ccc(cc1)-c1ccon1 InChI=1S/C29H24N2O7/c1-36-21-12-8-19(9-13-21)27(33)25-26(22-4-2-3-5-24(22)37-17-15-32)31(29(35)28(25)34)20-10-6-18(7-11-20)23-14-16-38-30-23/h2-14,16,26,32,34H,15,17H2,1H3 VUUMTNDPPWQPTP-UHFFFAOYSA-N 50532083 CHEMBL4557885 P2X purinoceptor 3 Homo sapiens 49 ChEMBL 10.1016/j.bmcl.2019.01.039 10.7270/Q23F4T48 30728111 Tobinaga, H; Kameyama, T; Asahi, K; Horiguchi, T; Oohara, M; Tada, Y; Fuchino, K; Jikihara, S; Endoh, T; Kurihara, N; Kanda, Y; Ogawa, M; Tamura, N; Yagi, S; Taniguchi, E; Takahara, Y; Shimada, S; Takeyama, C; Yamamoto, S; Shinohara, S; Kai, H Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50532083 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50532083&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365714 440740665 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51311227 Cc1nc(no1)-c1ccc(cc1)N1C(C(C(=O)C(C)(C)C)=C(O)C1=O)c1ccccc1OCCO InChI=1S/C26H27N3O6/c1-15-27-24(28-35-15)16-9-11-17(12-10-16)29-21(18-7-5-6-8-19(18)34-14-13-30)20(22(31)25(29)33)23(32)26(2,3)4/h5-12,21,30-31H,13-14H2,1-4H3 QJLZVQJRDNURDX-UHFFFAOYSA-N 50532074 CHEMBL4456152 P2X purinoceptor 3 Homo sapiens 700 ChEMBL 10.1016/j.bmcl.2019.01.039 10.7270/Q23F4T48 30728111 Tobinaga, H; Kameyama, T; Asahi, K; Horiguchi, T; Oohara, M; Tada, Y; Fuchino, K; Jikihara, S; Endoh, T; Kurihara, N; Kanda, Y; Ogawa, M; Tamura, N; Yagi, S; Taniguchi, E; Takahara, Y; Shimada, S; Takeyama, C; Yamamoto, S; Shinohara, S; Kai, H Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50532074 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50532074&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58366073 440740656 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51311228 [Na+].COc1ccccc1[C@H]1N(C(=O)C([O-])=C1C(=O)C(C)C)c1ccc(cc1)-c1ccsc1 InChI=1S/C25H23NO4S.Na/c1-15(2)23(27)21-22(19-6-4-5-7-20(19)30-3)26(25(29)24(21)28)18-10-8-16(9-11-18)17-12-13-31-14-17;/h4-15,22,28H,1-3H3;/q;+1/p-1/t22-;/m1./s1 KZWVKUWRMFLIAT-VZYDHVRKSA-M 50532062 CHEMBL4439812 P2X purinoceptor 3 Homo sapiens 8.0 ChEMBL 10.1016/j.bmcl.2019.01.039 10.7270/Q23F4T48 30728111 Tobinaga, H; Kameyama, T; Asahi, K; Horiguchi, T; Oohara, M; Tada, Y; Fuchino, K; Jikihara, S; Endoh, T; Kurihara, N; Kanda, Y; Ogawa, M; Tamura, N; Yagi, S; Taniguchi, E; Takahara, Y; Shimada, S; Takeyama, C; Yamamoto, S; Shinohara, S; Kai, H Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50532062 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50532062&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155514125 440740644 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51311234 COc1ccccc1C1N(C(=O)C(O)=C1C(=O)C(C)C)c1ccc(cc1)-c1ccsc1 InChI=1S/C25H23NO4S/c1-15(2)23(27)21-22(19-6-4-5-7-20(19)30-3)26(25(29)24(21)28)18-10-8-16(9-11-18)17-12-13-31-14-17/h4-15,22,28H,1-3H3 AMVDJWNLJDFPBW-UHFFFAOYSA-N 50532081 CHEMBL4454941 P2X purinoceptor 3 Homo sapiens 16 ChEMBL 10.1016/j.bmcl.2019.01.039 10.7270/Q23F4T48 30728111 Tobinaga, H; Kameyama, T; Asahi, K; Horiguchi, T; Oohara, M; Tada, Y; Fuchino, K; Jikihara, S; Endoh, T; Kurihara, N; Kanda, Y; Ogawa, M; Tamura, N; Yagi, S; Taniguchi, E; Takahara, Y; Shimada, S; Takeyama, C; Yamamoto, S; Shinohara, S; Kai, H Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50532081 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50532081&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365686 440740663 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51311237 COc1ccc(cc1)C(=O)C1=C(O)C(=O)N(C1c1ccccc1OC)c1ccc(cc1)-c1ccon1 InChI=1S/C28H22N2O6/c1-34-20-13-9-18(10-14-20)26(31)24-25(21-5-3-4-6-23(21)35-2)30(28(33)27(24)32)19-11-7-17(8-12-19)22-15-16-36-29-22/h3-16,25,32H,1-2H3 DUOBRJOSFTXCLL-UHFFFAOYSA-N 50532084 CHEMBL4544543 P2X purinoceptor 3 Homo sapiens 140 ChEMBL 10.1016/j.bmcl.2019.01.039 10.7270/Q23F4T48 30728111 Tobinaga, H; Kameyama, T; Asahi, K; Horiguchi, T; Oohara, M; Tada, Y; Fuchino, K; Jikihara, S; Endoh, T; Kurihara, N; Kanda, Y; Ogawa, M; Tamura, N; Yagi, S; Taniguchi, E; Takahara, Y; Shimada, S; Takeyama, C; Yamamoto, S; Shinohara, S; Kai, H Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50532084 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50532084&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 25097457 440740666 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51311238 CC(C)(C)C(=O)C1=C(O)C(=O)N(C1c1ccccc1OCCO)c1ccc(cc1)-c1ccoc1 InChI=1S/C27H27NO6/c1-27(2,3)25(31)22-23(20-6-4-5-7-21(20)34-15-13-29)28(26(32)24(22)30)19-10-8-17(9-11-19)18-12-14-33-16-18/h4-12,14,16,23,29-30H,13,15H2,1-3H3 ZPGZYXSTCTWACC-UHFFFAOYSA-N 50532075 CHEMBL4562022 P2X purinoceptor 3 Homo sapiens 35 ChEMBL 10.1016/j.bmcl.2019.01.039 10.7270/Q23F4T48 30728111 Tobinaga, H; Kameyama, T; Asahi, K; Horiguchi, T; Oohara, M; Tada, Y; Fuchino, K; Jikihara, S; Endoh, T; Kurihara, N; Kanda, Y; Ogawa, M; Tamura, N; Yagi, S; Taniguchi, E; Takahara, Y; Shimada, S; Takeyama, C; Yamamoto, S; Shinohara, S; Kai, H Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50532075 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50532075&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58366053 440740657 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51311239 CN(C)CCOc1ccccc1C1N(C(=O)C(O)=C1C(=O)C(C)(C)C)c1ccc(cc1)-c1ccsc1 InChI=1S/C29H32N2O4S/c1-29(2,3)27(33)24-25(22-8-6-7-9-23(22)35-16-15-30(4)5)31(28(34)26(24)32)21-12-10-19(11-13-21)20-14-17-36-18-20/h6-14,17-18,25,32H,15-16H2,1-5H3 RWZHELGYKXQYMX-UHFFFAOYSA-N 50532082 CHEMBL4572081 P2X purinoceptor 3 Homo sapiens 15 ChEMBL 10.1016/j.bmcl.2019.01.039 10.7270/Q23F4T48 30728111 Tobinaga, H; Kameyama, T; Asahi, K; Horiguchi, T; Oohara, M; Tada, Y; Fuchino, K; Jikihara, S; Endoh, T; Kurihara, N; Kanda, Y; Ogawa, M; Tamura, N; Yagi, S; Taniguchi, E; Takahara, Y; Shimada, S; Takeyama, C; Yamamoto, S; Shinohara, S; Kai, H Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50532082 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50532082&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365501 440740664 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51311240 CC(C)C(=O)C1=C(O)C(=O)N(C1c1ccccc1OCCO)c1ccc(cc1)-c1ccsc1 InChI=1S/C26H25NO5S/c1-16(2)24(29)22-23(20-5-3-4-6-21(20)32-13-12-28)27(26(31)25(22)30)19-9-7-17(8-10-19)18-11-14-33-15-18/h3-11,14-16,23,28,30H,12-13H2,1-2H3 FDLDOOPLMYSDGD-UHFFFAOYSA-N 50532066 CHEMBL4537290 P2X purinoceptor 3 Homo sapiens 13 ChEMBL 10.1016/j.bmcl.2019.01.039 10.7270/Q23F4T48 30728111 Tobinaga, H; Kameyama, T; Asahi, K; Horiguchi, T; Oohara, M; Tada, Y; Fuchino, K; Jikihara, S; Endoh, T; Kurihara, N; Kanda, Y; Ogawa, M; Tamura, N; Yagi, S; Taniguchi, E; Takahara, Y; Shimada, S; Takeyama, C; Yamamoto, S; Shinohara, S; Kai, H Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50532066 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50532066&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365995 440740648 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51311241 OC(=O)c1ccc(cc1)C(=O)C1=C(O)C(=O)N(C1C1CCCCC1)c1ccc(cc1)-c1ccon1 InChI=1S/C27H24N2O6/c30-24(18-6-8-19(9-7-18)27(33)34)22-23(17-4-2-1-3-5-17)29(26(32)25(22)31)20-12-10-16(11-13-20)21-14-15-35-28-21/h6-15,17,23,31H,1-5H2,(H,33,34) QTJAYHDQWCPUTJ-UHFFFAOYSA-N 50532085 CHEMBL4532166 P2X purinoceptor 3 Homo sapiens 203 ChEMBL 10.1016/j.bmcl.2019.01.039 10.7270/Q23F4T48 30728111 Tobinaga, H; Kameyama, T; Asahi, K; Horiguchi, T; Oohara, M; Tada, Y; Fuchino, K; Jikihara, S; Endoh, T; Kurihara, N; Kanda, Y; Ogawa, M; Tamura, N; Yagi, S; Taniguchi, E; Takahara, Y; Shimada, S; Takeyama, C; Yamamoto, S; Shinohara, S; Kai, H Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50532085 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50532085&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58045034 440740667 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315761 CC(C)(C)OC(=O)N1CCc2c(C1)sc1ncn(CCc3ccccc3)c(=O)c21 InChI=1S/C22H25N3O3S/c1-22(2,3)28-21(27)24-12-10-16-17(13-24)29-19-18(16)20(26)25(14-23-19)11-9-15-7-5-4-6-8-15/h4-8,14H,9-13H2,1-3H3 NEHXPYLVSLJGAQ-UHFFFAOYSA-N 50532985 CHEMBL4446408 P2X purinoceptor 3 Homo sapiens 9900 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50532985 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50532985&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155518757 440741567 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315762 COc1ccccc1CCn1cnc2sc3CN(CCc3c2c1=O)C(=O)OC(C)(C)C InChI=1S/C23H27N3O4S/c1-23(2,3)30-22(28)25-12-10-16-18(13-25)31-20-19(16)21(27)26(14-24-20)11-9-15-7-5-6-8-17(15)29-4/h5-8,14H,9-13H2,1-4H3 LOIJPBFYQBYKEK-UHFFFAOYSA-N 50532975 CHEMBL4567453 P2X purinoceptor 3 Homo sapiens 1300 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50532975 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50532975&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155550493 440741557 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315763 CC(C)N1Cc2c(nc(nc2NC(C)(C)Cc2ccc(Cl)cc2)N2CCN(CC2)C(C)=O)C1=O InChI=1S/C25H33ClN6O2/c1-16(2)32-15-20-21(23(32)34)27-24(31-12-10-30(11-13-31)17(3)33)28-22(20)29-25(4,5)14-18-6-8-19(26)9-7-18/h6-9,16H,10-15H2,1-5H3,(H,27,28,29) QPDPLVXCWWSXFN-UHFFFAOYSA-N 50379707 CHEMBL2011112 P2X purinoceptor 3 Homo sapiens 25 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50379707 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50379707&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 25122581 160858790 CHEMBL2011112 ZINC68247086 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315764 C[C@H](CN1CCN(CC1)C(C)=O)NC(=O)c1cc2c(nn(C)c2s1)-c1ccccc1 InChI=1S/C22H27N5O2S/c1-15(14-26-9-11-27(12-10-26)16(2)28)23-21(29)19-13-18-20(17-7-5-4-6-8-17)24-25(3)22(18)30-19/h4-8,13,15H,9-12,14H2,1-3H3,(H,23,29)/t15-/m1/s1 WLMBSKSEPQCRJV-OAHLLOKOSA-N 50415550 CHEMBL599760::Ro-85 P2X purinoceptor 3 Homo sapiens 2400 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50415550 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50415550&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 46175179 163364574 CHEMBL599760 ZINC45357437 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315765 OC(=O)c1cc(C(O)=O)c(cc1C(O)=O)C(=O)N(Cc1cccc(Oc2ccccc2)c1)[C@H]1CCCc2ccccc12 InChI=1S/C33H27NO8/c35-30(25-17-27(32(38)39)28(33(40)41)18-26(25)31(36)37)34(29-15-7-10-21-9-4-5-14-24(21)29)19-20-8-6-13-23(16-20)42-22-11-2-1-3-12-22/h1-6,8-9,11-14,16-18,29H,7,10,15,19H2,(H,36,37)(H,38,39)(H,40,41)/t29-/m0/s1 VQGBOYBIENNKMI-LJAQVGFWSA-N 86478 A-317491 P2X purinoceptor 3 Homo sapiens 220 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86478 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86478&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 71C 5SVR 9829395 136352527 4115 ZINC03990058 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315766 COc1cc(CCn2cnc3sc4CN(CCc4c3c2=O)S(=O)(=O)N(C)C)cc(OC)c1 InChI=1S/C21H26N4O5S2/c1-23(2)32(27,28)25-8-6-17-18(12-25)31-20-19(17)21(26)24(13-22-20)7-5-14-9-15(29-3)11-16(10-14)30-4/h9-11,13H,5-8,12H2,1-4H3 SPRVGEMMLXHYMC-UHFFFAOYSA-N 50532986 CHEMBL4460871 P2X purinoceptor 3 Homo sapiens 50 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50532986 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50532986&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155528131 440741568 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315767 COc1ccc(OC)c(CCn2cnc3sc4CN(CCc4c3c2=O)S(=O)(=O)N(C)C)c1 InChI=1S/C21H26N4O5S2/c1-23(2)32(27,28)25-10-8-16-18(12-25)31-20-19(16)21(26)24(13-22-20)9-7-14-11-15(29-3)5-6-17(14)30-4/h5-6,11,13H,7-10,12H2,1-4H3 VTJCBRSDHQACLF-UHFFFAOYSA-N 50532987 CHEMBL4458821 P2X purinoceptor 3 Homo sapiens 20 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50532987 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50532987&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155526703 440741569 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315768 COc1ccc(OC)c(CC(C)n2cnc3sc4CN(CCc4c3c2=O)S(=O)(=O)N(C)C)c1 InChI=1S/C22H28N4O5S2/c1-14(10-15-11-16(30-4)6-7-18(15)31-5)26-13-23-21-20(22(26)27)17-8-9-25(12-19(17)32-21)33(28,29)24(2)3/h6-7,11,13-14H,8-10,12H2,1-5H3 MQSYMKAYRWSBQB-UHFFFAOYSA-N 50532988 CHEMBL4590779 P2X purinoceptor 3 Homo sapiens 3300 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50532988 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50532988&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155568671 440741570 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315769 COc1ccc(Cl)cc1CCn1cnc2sc3CN(CCc3c2c1=O)S(=O)(=O)N(C)C InChI=1S/C20H23ClN4O4S2/c1-23(2)31(27,28)25-9-7-15-17(11-25)30-19-18(15)20(26)24(12-22-19)8-6-13-10-14(21)4-5-16(13)29-3/h4-5,10,12H,6-9,11H2,1-3H3 ZCCYHYVRGKVMEH-UHFFFAOYSA-N 50532989 CHEMBL4442508 P2X purinoceptor 3 Homo sapiens 35 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50532989 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50532989&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155515950 440741571 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315770 CN(C)S(=O)(=O)N1CCc2c(C1)sc1ncn(CCc3ccccc3OC(F)(F)F)c(=O)c21 InChI=1S/C20H21F3N4O4S2/c1-25(2)33(29,30)27-10-8-14-16(11-27)32-18-17(14)19(28)26(12-24-18)9-7-13-5-3-4-6-15(13)31-20(21,22)23/h3-6,12H,7-11H2,1-2H3 RKGWXYCRRYVGMM-UHFFFAOYSA-N 50532990 CHEMBL4453198 P2X purinoceptor 3 Homo sapiens 180 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50532990 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50532990&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155523291 440741572 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315771 COc1cc(CCn2cnc3sc4CN(CCc4c3c2=O)S(N)(=O)=O)cc(OC)c1 InChI=1S/C19H22N4O5S2/c1-27-13-7-12(8-14(9-13)28-2)3-5-22-11-21-18-17(19(22)24)15-4-6-23(30(20,25)26)10-16(15)29-18/h7-9,11H,3-6,10H2,1-2H3,(H2,20,25,26) YPILIMJLSMUQTA-UHFFFAOYSA-N 50532991 CHEMBL4463088 P2X purinoceptor 3 Homo sapiens 650 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50532991 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50532991&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155529657 440741573 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315772 COc1cc(CCn2cnc3sc4CC(CCc4c3c2=O)N2CCSC2)cc(OC)c1 InChI=1S/C23H27N3O3S2/c1-28-17-9-15(10-18(12-17)29-2)5-6-25-13-24-22-21(23(25)27)19-4-3-16(11-20(19)31-22)26-7-8-30-14-26/h9-10,12-13,16H,3-8,11,14H2,1-2H3 GEOYUYBTJRDKQT-UHFFFAOYSA-N 50532992 CHEMBL4568398 P2X purinoceptor 3 Homo sapiens 140 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50532992 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50532992&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155560573 440741574 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315773 COc1cc(CCn2cnc3sc4CS(=O)(=O)CCc4c3c2=O)cc(OC)c1 InChI=1S/C19H20N2O5S2/c1-25-13-7-12(8-14(9-13)26-2)3-5-21-11-20-18-17(19(21)22)15-4-6-28(23,24)10-16(15)27-18/h7-9,11H,3-6,10H2,1-2H3 SELGQMNEAIRGJD-UHFFFAOYSA-N 50532993 CHEMBL4571607 P2X purinoceptor 3 Homo sapiens 1300 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50532993 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50532993&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155562606 440741575 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315774 COc1ccc(OC)c(CCn2cnc3sc4CN(CCc4c3c2=O)C(C)=O)c1 InChI=1S/C21H23N3O4S/c1-13(25)23-9-7-16-18(11-23)29-20-19(16)21(26)24(12-22-20)8-6-14-10-15(27-2)4-5-17(14)28-3/h4-5,10,12H,6-9,11H2,1-3H3 SMIWFLCSKIEXDF-UHFFFAOYSA-N 50532994 CHEMBL4565455 P2X purinoceptor 3 Homo sapiens 140 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50532994 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50532994&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155544746 440741576 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315775 COc1ccc(OC)c(CCn2cnc3sc4CN(CCc4c3c2=O)C(=O)C(C)(C)C)c1 InChI=1S/C24H29N3O4S/c1-24(2,3)23(29)26-11-9-17-19(13-26)32-21-20(17)22(28)27(14-25-21)10-8-15-12-16(30-4)6-7-18(15)31-5/h6-7,12,14H,8-11,13H2,1-5H3 SGEDKVGYMLOFQQ-UHFFFAOYSA-N 50532995 CHEMBL4476395 P2X purinoceptor 3 Homo sapiens 10.0 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50532995 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50532995&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155538262 440741577 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315776 CCC(C)(C)C(=O)N1CCc2c(C1)sc1ncn(CCc3cc(OC)cc(OC)c3)c(=O)c21 InChI=1S/C25H31N3O4S/c1-6-25(2,3)24(30)27-10-8-19-20(14-27)33-22-21(19)23(29)28(15-26-22)9-7-16-11-17(31-4)13-18(12-16)32-5/h11-13,15H,6-10,14H2,1-5H3 NJVGOSUDSKLXFI-UHFFFAOYSA-N 50532996 CHEMBL4542098 P2X purinoceptor 3 Homo sapiens 15 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50532996 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50532996&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155551563 440741578 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315777 COc1cc(CCn2cnc3sc4CN(CCc4c3c2=O)C(=O)C(C)(F)F)cc(OC)c1 InChI=1S/C22H23F2N3O4S/c1-22(23,24)21(29)26-7-5-16-17(11-26)32-19-18(16)20(28)27(12-25-19)6-4-13-8-14(30-2)10-15(9-13)31-3/h8-10,12H,4-7,11H2,1-3H3 LFGCHJQQRAFMOI-UHFFFAOYSA-N 50532997 CHEMBL4439566 P2X purinoceptor 3 Homo sapiens 15 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50532997 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50532997&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155513864 440741579 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315778 COc1cc(CCn2cnc3sc4CN(CCc4c3c2=O)C(=O)C(F)(F)F)cc(OC)c1 InChI=1S/C21H20F3N3O4S/c1-30-13-7-12(8-14(9-13)31-2)3-5-27-11-25-18-17(19(27)28)15-4-6-26(10-16(15)32-18)20(29)21(22,23)24/h7-9,11H,3-6,10H2,1-2H3 MEFNUCYNHDRJFW-UHFFFAOYSA-N 50532998 CHEMBL4587231 P2X purinoceptor 3 Homo sapiens 15 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50532998 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50532998&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155566512 440741580 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315779 COc1cc(CCn2cnc3sc4CN(CCc4c3c2=O)C(=O)CO)cc(OC)c1 InChI=1S/C21H23N3O5S/c1-28-14-7-13(8-15(9-14)29-2)3-5-24-12-22-20-19(21(24)27)16-4-6-23(18(26)11-25)10-17(16)30-20/h7-9,12,25H,3-6,10-11H2,1-2H3 VKBGJWSZBAWKII-UHFFFAOYSA-N 50532999 CHEMBL4451343 P2X purinoceptor 3 Homo sapiens 180 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50532999 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50532999&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155521633 440741581 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315780 COc1cc(CCn2cnc3sc4CN(CCc4c3c2=O)C(=O)CN(C)C)cc(OC)c1 InChI=1S/C23H28N4O4S/c1-25(2)13-20(28)26-8-6-18-19(12-26)32-22-21(18)23(29)27(14-24-22)7-5-15-9-16(30-3)11-17(10-15)31-4/h9-11,14H,5-8,12-13H2,1-4H3 HQHFILMGEBTBTN-UHFFFAOYSA-N 50533000 CHEMBL4578016 P2X purinoceptor 3 Homo sapiens 1000 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533000 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533000&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155564816 440741582 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315781 COc1cc(CCn2cnc3sc4CN(CCc4c3c2=O)S(C)(=O)=O)cc(OC)c1 InChI=1S/C20H23N3O5S2/c1-27-14-8-13(9-15(10-14)28-2)4-6-22-12-21-19-18(20(22)24)16-5-7-23(30(3,25)26)11-17(16)29-19/h8-10,12H,4-7,11H2,1-3H3 GQQMAFKUBRMNLZ-UHFFFAOYSA-N 50533001 CHEMBL4515308 P2X purinoceptor 3 Homo sapiens 40 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533001 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533001&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155540008 440741583 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315782 COc1cc(CCn2cnc3sc4CN(CCc4c3c2=O)S(=O)(=O)C2CCCC2)cc(OC)c1 InChI=1S/C24H29N3O5S2/c1-31-17-11-16(12-18(13-17)32-2)7-9-26-15-25-23-22(24(26)28)20-8-10-27(14-21(20)33-23)34(29,30)19-5-3-4-6-19/h11-13,15,19H,3-10,14H2,1-2H3 VXBOFAACMMKOEG-UHFFFAOYSA-N 50533002 CHEMBL4440083 P2X purinoceptor 3 Homo sapiens 40 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533002 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533002&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155514547 440741584 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315783 CCOC(=O)C1CCc2c(C1)sc1ncn(CCc3cc(OC)ccc3OC)c(=O)c21 InChI=1S/C23H26N2O5S/c1-4-30-23(27)15-5-7-17-19(12-15)31-21-20(17)22(26)25(13-24-21)10-9-14-11-16(28-2)6-8-18(14)29-3/h6,8,11,13,15H,4-5,7,9-10,12H2,1-3H3 YESOMKWNPIOVSW-UHFFFAOYSA-N 50533003 CHEMBL4547802 P2X purinoceptor 3 Homo sapiens 48 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533003 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533003&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155553704 440741585 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315784 COc1ccc(OC)c(CCn2cnc3sc4CC(CCc4c3c2=O)C(=O)N(C)C)c1 InChI=1S/C23H27N3O4S/c1-25(2)22(27)15-5-7-17-19(12-15)31-21-20(17)23(28)26(13-24-21)10-9-14-11-16(29-3)6-8-18(14)30-4/h6,8,11,13,15H,5,7,9-10,12H2,1-4H3 FZCDZTJYZBKDBO-UHFFFAOYSA-N 50533004 CHEMBL4546396 P2X purinoceptor 3 Homo sapiens 33 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533004 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533004&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155552357 440741586 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315786 COc1ccccc1CCn1cnc2sc3CN(CCc3c2c1=O)S(=O)(=O)N1CCCC1 InChI=1S/C22H26N4O4S2/c1-30-18-7-3-2-6-16(18)8-12-24-15-23-21-20(22(24)27)17-9-13-26(14-19(17)31-21)32(28,29)25-10-4-5-11-25/h2-3,6-7,15H,4-5,8-14H2,1H3 RRLOGTRSEFIJIN-UHFFFAOYSA-N 50532974 CHEMBL4516592 P2X purinoceptor 3 Homo sapiens 720 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50532974 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50532974&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155540285 440741556 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315787 COc1ccccc1CCn1cnc2sc3CN(CCc3c2c1=O)C(=O)NC(C)C InChI=1S/C22H26N4O3S/c1-14(2)24-22(28)25-11-9-16-18(12-25)30-20-19(16)21(27)26(13-23-20)10-8-15-6-4-5-7-17(15)29-3/h4-7,13-14H,8-12H2,1-3H3,(H,24,28) BEORWYMSHLCMOP-UHFFFAOYSA-N 50533005 CHEMBL4467705 P2X purinoceptor 3 Homo sapiens 10700 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533005 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533005&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155532585 440741587 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315788 COc1cc(C(C)C)c(Oc2cnc(N)nc2N)cc1S(N)(=O)=O InChI=1S/C14H19N5O4S/c1-7(2)8-4-10(22-3)12(24(17,20)21)5-9(8)23-11-6-18-14(16)19-13(11)15/h4-7H,1-3H3,(H2,17,20,21)(H4,15,16,18,19) HLWURFKMDLAKOD-UHFFFAOYSA-N 50533006 Af-219::Gefapixant::R-1646::R1646::RG-1646::RG1646::RO-4926219::RO4926219 P2X purinoceptor 3 Homo sapiens 45 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533006 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533006&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search AF9 5YVE 24764487 440741588 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315789 COc1ccc(OC)c(CCOc2ncnc3sc4CN(CCc4c23)S(=O)(=O)N(C)C)c1 InChI=1S/C21H26N4O5S2/c1-24(2)32(26,27)25-9-7-16-18(12-25)31-21-19(16)20(22-13-23-21)30-10-8-14-11-15(28-3)5-6-17(14)29-4/h5-6,11,13H,7-10,12H2,1-4H3 XFQIQNBCLGRSFE-UHFFFAOYSA-N 50533007 CHEMBL4463658 P2X purinoceptor 3 Homo sapiens 7400 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533007 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533007&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155530178 440741589 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315790 CN(C)S(=O)(=O)N1CCc2c(C1)sc1ncn(CCc3c(Cl)ccc(Cl)c3F)c(=O)c21 InChI=1S/C19H19Cl2FN4O3S2/c1-24(2)31(28,29)26-8-6-12-15(9-26)30-18-16(12)19(27)25(10-23-18)7-5-11-13(20)3-4-14(21)17(11)22/h3-4,10H,5-9H2,1-2H3 VFJDKUDBQVGZAS-UHFFFAOYSA-N 50533008 CHEMBL4524275 P2X purinoceptor 3 Homo sapiens 380 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533008 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533008&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155520066 440741590 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315791 COc1cc(CCn2cnc3sc4CN(CCc4c3c2=O)C(=O)CC(C)C)cc(OC)c1 InChI=1S/C24H29N3O4S/c1-15(2)9-21(28)26-8-6-19-20(13-26)32-23-22(19)24(29)27(14-25-23)7-5-16-10-17(30-3)12-18(11-16)31-4/h10-12,14-15H,5-9,13H2,1-4H3 ZLKMWUJTCNZEHD-UHFFFAOYSA-N 50533009 CHEMBL4444041 P2X purinoceptor 3 Homo sapiens 40 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533009 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533009&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155517023 440741591 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315792 COc1cc(CCn2cnc3sc4CN(CCc4c3c2=O)C(=O)C(C)(C)O)cc(OC)c1 InChI=1S/C23H27N3O5S/c1-23(2,29)22(28)25-8-6-17-18(12-25)32-20-19(17)21(27)26(13-24-20)7-5-14-9-15(30-3)11-16(10-14)31-4/h9-11,13,29H,5-8,12H2,1-4H3 HAXTZLKLKPSLQF-UHFFFAOYSA-N 50533010 CHEMBL4563035 P2X purinoceptor 3 Homo sapiens 55 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533010 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533010&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155559341 440741592 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315793 COc1ccc(OC)c(CCn2cnc3sc4CC(CCc4c3c2=O)C(O)=O)c1 InChI=1S/C21H22N2O5S/c1-27-14-4-6-16(28-2)12(9-14)7-8-23-11-22-19-18(20(23)24)15-5-3-13(21(25)26)10-17(15)29-19/h4,6,9,11,13H,3,5,7-8,10H2,1-2H3,(H,25,26) ZSENWGJYPCTXDA-UHFFFAOYSA-N 50533011 CHEMBL4567591 P2X purinoceptor 3 Homo sapiens 1000 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533011 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533011&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155558453 440741593 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315794 COc1ccccc1CCn1cnc2sc3CN(CCc3c2c1=O)S(=O)(=O)N(C)C InChI=1S/C20H24N4O4S2/c1-22(2)30(26,27)24-11-9-15-17(12-24)29-19-18(15)20(25)23(13-21-19)10-8-14-6-4-5-7-16(14)28-3/h4-7,13H,8-12H2,1-3H3 POPFQBKOBJMISL-UHFFFAOYSA-N 50532967 CHEMBL4454932 P2X purinoceptor 3 Homo sapiens 440 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50532967 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50532967&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155524156 440741549 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315795 COc1ccccc1CCn1cnc2sc3CN(CCc3c2c1=O)C(=O)NC(C)C InChI=1S/C22H26N4O3S/c1-14(2)24-22(28)25-11-9-16-18(12-25)30-20-19(16)21(27)26(13-23-20)10-8-15-6-4-5-7-17(15)29-3/h4-7,13-14H,8-12H2,1-3H3,(H,24,28) BEORWYMSHLCMOP-UHFFFAOYSA-N 50533005 CHEMBL4467705 P2X purinoceptor 3 Homo sapiens 10700 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533005 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533005&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155532585 440741587 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315796 CC(C)(C)OC(=O)N1CCc2c(C1)sc1ncn(CCc3ccccc3[N+]([O-])=O)c(=O)c21 InChI=1S/C22H24N4O5S/c1-22(2,3)31-21(28)24-11-9-15-17(12-24)32-19-18(15)20(27)25(13-23-19)10-8-14-6-4-5-7-16(14)26(29)30/h4-7,13H,8-12H2,1-3H3 FLLPYBKYUHJJGN-UHFFFAOYSA-N 50533012 CHEMBL4549156 P2X purinoceptor 3 Homo sapiens 5700 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533012 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533012&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155548909 440741594 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315797 CN(C)S(=O)(=O)N1CCc2c(C1)sc1ncn(CCc3c(Cl)ccc(Cl)c3F)c(=O)c21 InChI=1S/C19H19Cl2FN4O3S2/c1-24(2)31(28,29)26-8-6-12-15(9-26)30-18-16(12)19(27)25(10-23-18)7-5-11-13(20)3-4-14(21)17(11)22/h3-4,10H,5-9H2,1-2H3 VFJDKUDBQVGZAS-UHFFFAOYSA-N 50533008 CHEMBL4524275 P2X purinoceptor 3 Homo sapiens 380 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533008 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533008&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155520066 440741590 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315798 COc1cc(CCn2cnc3sc4CC(=O)CCc4c3c2=O)cc(OC)c1 InChI=1S/C20H20N2O4S/c1-25-14-7-12(8-15(10-14)26-2)5-6-22-11-21-19-18(20(22)24)16-4-3-13(23)9-17(16)27-19/h7-8,10-11H,3-6,9H2,1-2H3 LOPOSNPJGIWCBF-UHFFFAOYSA-N 50533013 CHEMBL4565351 P2X purinoceptor 3 Homo sapiens 6800 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533013 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533013&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155544725 440741595 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315799 COc1cc(CCn2cnc3sc4CN(CCc4c3c2=O)C(=O)CC(C)C)cc(OC)c1 InChI=1S/C24H29N3O4S/c1-15(2)9-21(28)26-8-6-19-20(13-26)32-23-22(19)24(29)27(14-25-23)7-5-16-10-17(30-3)12-18(11-16)31-4/h10-12,14-15H,5-9,13H2,1-4H3 ZLKMWUJTCNZEHD-UHFFFAOYSA-N 50533009 CHEMBL4444041 P2X purinoceptor 3 Homo sapiens 40 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533009 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533009&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155517023 440741591 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315800 COc1ccc(OC)c(CCn2cnc3sc4CC(CCc4c3c2=O)C(O)=O)c1 InChI=1S/C21H22N2O5S/c1-27-14-4-6-16(28-2)12(9-14)7-8-23-11-22-19-18(20(23)24)15-5-3-13(21(25)26)10-17(15)29-19/h4,6,9,11,13H,3,5,7-8,10H2,1-2H3,(H,25,26) ZSENWGJYPCTXDA-UHFFFAOYSA-N 50533011 CHEMBL4567591 P2X purinoceptor 3 Homo sapiens 1000 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533011 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533011&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155558453 440741593 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315802 COc1cc(CCn2cnc3sc4CN(CCc4c3c2=O)S(=O)(=O)N2CCCCC2)cc(OC)c1 InChI=1S/C24H30N4O5S2/c1-32-18-12-17(13-19(14-18)33-2)6-10-26-16-25-23-22(24(26)29)20-7-11-28(15-21(20)34-23)35(30,31)27-8-4-3-5-9-27/h12-14,16H,3-11,15H2,1-2H3 VUXCMRQCCAQUJU-UHFFFAOYSA-N 50533014 CHEMBL4559858 P2X purinoceptor 3 Homo sapiens 150 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533014 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533014&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155557786 440741596 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315803 COc1ccccc1CCn1cnc2sc3CN(CCc3c2c1=O)S(=O)(=O)N1CCCCC1 InChI=1S/C23H28N4O4S2/c1-31-19-8-4-3-7-17(19)9-13-25-16-24-22-21(23(25)28)18-10-14-27(15-20(18)32-22)33(29,30)26-11-5-2-6-12-26/h3-4,7-8,16H,2,5-6,9-15H2,1H3 KBJFLNHUSYJTSU-UHFFFAOYSA-N 50532976 CHEMBL4549675 P2X purinoceptor 3 Homo sapiens 850 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50532976 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50532976&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155543528 440741558 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315804 COc1ccccc1CCn1cnc2sc3CN(CCc3c2c1=O)S(=O)(=O)c1ccccc1 InChI=1S/C24H23N3O4S2/c1-31-20-10-6-5-7-17(20)11-13-26-16-25-23-22(24(26)28)19-12-14-27(15-21(19)32-23)33(29,30)18-8-3-2-4-9-18/h2-10,16H,11-15H2,1H3 BTJZESDMZLYDEY-UHFFFAOYSA-N 50532977 CHEMBL4531994 P2X purinoceptor 3 Homo sapiens 810 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50532977 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50532977&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 42666540 440741559 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315805 COc1ccccc1CCn1cnc2sc3CN(CCc3c2c1=O)C(=O)N1CCCC1 InChI=1S/C23H26N4O3S/c1-30-18-7-3-2-6-16(18)8-12-27-15-24-21-20(22(27)28)17-9-13-26(14-19(17)31-21)23(29)25-10-4-5-11-25/h2-3,6-7,15H,4-5,8-14H2,1H3 REQFVEBVRQSIBC-UHFFFAOYSA-N 50533015 CHEMBL4557380 P2X purinoceptor 3 Homo sapiens 1600 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533015 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533015&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155554392 440741597 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315806 COc1ccccc1CCn1cnc2sc3CN(CCc3c2c1=O)C(=O)N(C)C InChI=1S/C21H24N4O3S/c1-23(2)21(27)24-11-9-15-17(12-24)29-19-18(15)20(26)25(13-22-19)10-8-14-6-4-5-7-16(14)28-3/h4-7,13H,8-12H2,1-3H3 INGYNNDDJIOBJA-UHFFFAOYSA-N 50532979 CHEMBL4439753 P2X purinoceptor 3 Homo sapiens 1300 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50532979 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50532979&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 42795648 440741561 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315807 COc1cc(CCn2cnc3sc4CN(CCc4c3c2=O)C(=O)OC(C)(C)C)cc(OC)c1 InChI=1S/C24H29N3O5S/c1-24(2,3)32-23(29)26-9-7-18-19(13-26)33-21-20(18)22(28)27(14-25-21)8-6-15-10-16(30-4)12-17(11-15)31-5/h10-12,14H,6-9,13H2,1-5H3 KYTBJMIMHRRYRW-UHFFFAOYSA-N 50532981 CHEMBL4471519 P2X purinoceptor 3 Homo sapiens 390 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50532981 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50532981&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155535354 440741563 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315808 COc1cccc(CCn2cnc3sc4CN(CCc4c3c2=O)C(=O)OC(C)(C)C)c1OC InChI=1S/C24H29N3O5S/c1-24(2,3)32-23(29)26-12-10-16-18(13-26)33-21-19(16)22(28)27(14-25-21)11-9-15-7-6-8-17(30-4)20(15)31-5/h6-8,14H,9-13H2,1-5H3 IIMWZHNSMXZLPX-UHFFFAOYSA-N 50533016 CHEMBL4460309 P2X purinoceptor 3 Homo sapiens 2400 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533016 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533016&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155527693 440741598 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315809 COc1ccc(CCn2cnc3sc4CN(CCc4c3c2=O)C(=O)OC(C)(C)C)cc1OC InChI=1S/C24H29N3O5S/c1-24(2,3)32-23(29)26-11-9-16-19(13-26)33-21-20(16)22(28)27(14-25-21)10-8-15-6-7-17(30-4)18(12-15)31-5/h6-7,12,14H,8-11,13H2,1-5H3 OSMFJRFWSDTZKZ-UHFFFAOYSA-N 50532982 CHEMBL4560167 P2X purinoceptor 3 Homo sapiens 3700 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50532982 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50532982&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155558639 440741564 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315810 COc1cccc(CCn2cnc3sc4CN(CCc4c3c2=O)C(=O)OC(C)(C)C)c1 InChI=1S/C23H27N3O4S/c1-23(2,3)30-22(28)25-11-9-17-18(13-25)31-20-19(17)21(27)26(14-24-20)10-8-15-6-5-7-16(12-15)29-4/h5-7,12,14H,8-11,13H2,1-4H3 VGMWBFAAPZXVTP-UHFFFAOYSA-N 50533017 CHEMBL4520865 P2X purinoceptor 3 Homo sapiens 3700 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533017 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533017&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155542440 440741599 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315811 CC(C)(C)OC(=O)N1CCc2c(C1)sc1ncn(CCc3ccccc3)c(=O)c21 InChI=1S/C22H25N3O3S/c1-22(2,3)28-21(27)24-12-10-16-17(13-24)29-19-18(16)20(26)25(14-23-19)11-9-15-7-5-4-6-8-15/h4-8,14H,9-13H2,1-3H3 NEHXPYLVSLJGAQ-UHFFFAOYSA-N 50532985 CHEMBL4446408 P2X purinoceptor 3 Homo sapiens 9900 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50532985 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50532985&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155518757 440741567 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315812 COc1ccccc1Cn1cnc2sc3CN(CCc3c2c1=O)C(=O)OC(C)(C)C InChI=1S/C22H25N3O4S/c1-22(2,3)29-21(27)24-10-9-15-17(12-24)30-19-18(15)20(26)25(13-23-19)11-14-7-5-6-8-16(14)28-4/h5-8,13H,9-12H2,1-4H3 YWRHPUXMSHPQKV-UHFFFAOYSA-N 50533018 CHEMBL4436079 P2X purinoceptor 3 Homo sapiens 6300 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533018 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533018&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155511587 440741600 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315813 COc1ccccc1CCn1cnc2sc3CN(CCc3c2c1=O)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C24H22FN3O4S2/c1-32-20-5-3-2-4-16(20)10-12-27-15-26-23-22(24(27)29)19-11-13-28(14-21(19)33-23)34(30,31)18-8-6-17(25)7-9-18/h2-9,15H,10-14H2,1H3 IFSYYEGWQCBGLX-UHFFFAOYSA-N 50533019 CHEMBL4589123 P2X purinoceptor 3 Homo sapiens 840 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533019 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533019&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134691714 440741601 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315814 CC(C)N1Cc2c(nc(nc2NC(C)(C)Cc2ccc(Cl)cc2)N2CCN(CC2)C(C)=O)C1=O InChI=1S/C25H33ClN6O2/c1-16(2)32-15-20-21(23(32)34)27-24(31-12-10-30(11-13-31)17(3)33)28-22(20)29-25(4,5)14-18-6-8-19(26)9-7-18/h6-9,16H,10-15H2,1-5H3,(H,27,28,29) QPDPLVXCWWSXFN-UHFFFAOYSA-N 50379707 CHEMBL2011112 P2X purinoceptor 3 Homo sapiens 25 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50379707 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50379707&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 25122581 160858790 CHEMBL2011112 ZINC68247086 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315815 COc1cc(C(C)C)c(Oc2cnc(N)nc2N)cc1I InChI=1S/C14H17IN4O2/c1-7(2)8-4-11(20-3)9(15)5-10(8)21-12-6-18-14(17)19-13(12)16/h4-7H,1-3H3,(H4,16,17,18,19) AATPYXMXFBBKFO-UHFFFAOYSA-N 50257636 5-(5-iodo-2-isopropyl-4-methoxyphenoxy)pyrimidine-2,4-diamine::CHEMBL526307 P2X purinoceptor 3 Homo sapiens 20 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50257636 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50257636&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 15953802 104108644 CHEMBL526307 ZINC34809174 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315816 OC(=O)c1cc(C(O)=O)c(cc1C(O)=O)C(=O)N(Cc1cccc(Oc2ccccc2)c1)[C@H]1CCCc2ccccc12 InChI=1S/C33H27NO8/c35-30(25-17-27(32(38)39)28(33(40)41)18-26(25)31(36)37)34(29-15-7-10-21-9-4-5-14-24(21)29)19-20-8-6-13-23(16-20)42-22-11-2-1-3-12-22/h1-6,8-9,11-14,16-18,29H,7,10,15,19H2,(H,36,37)(H,38,39)(H,40,41)/t29-/m0/s1 VQGBOYBIENNKMI-LJAQVGFWSA-N 86478 A-317491 P2X purinoceptor 3 Homo sapiens 220 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86478 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86478&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 71C 5SVR 9829395 136352527 4115 ZINC03990058 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315817 COc1cc(CCn2cnc3sc4CN(CCc4c3c2=O)S(=O)(=O)N(C)C)cc(OC)c1 InChI=1S/C21H26N4O5S2/c1-23(2)32(27,28)25-8-6-17-18(12-25)31-20-19(17)21(26)24(13-22-20)7-5-14-9-15(29-3)11-16(10-14)30-4/h9-11,13H,5-8,12H2,1-4H3 SPRVGEMMLXHYMC-UHFFFAOYSA-N 50532986 CHEMBL4460871 P2X purinoceptor 3 Homo sapiens 50 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50532986 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50532986&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155528131 440741568 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315818 COc1ccc(OC)c(c1)C(C)Cn1cnc2sc3CN(CCc3c2c1=O)S(=O)(=O)N(C)C InChI=1S/C22H28N4O5S2/c1-14(17-10-15(30-4)6-7-18(17)31-5)11-25-13-23-21-20(22(25)27)16-8-9-26(12-19(16)32-21)33(28,29)24(2)3/h6-7,10,13-14H,8-9,11-12H2,1-5H3 BCABBMIXRDTMRE-UHFFFAOYSA-N 50533020 CHEMBL4558507 P2X purinoceptor 3 Homo sapiens 1400 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533020 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533020&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155557542 440741602 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315819 CN(C)S(=O)(=O)N1CCc2c(C1)sc1ncn(CCc3cc(Cl)ccc3Cl)c(=O)c21 InChI=1S/C19H20Cl2N4O3S2/c1-23(2)30(27,28)25-8-6-14-16(10-25)29-18-17(14)19(26)24(11-22-18)7-5-12-9-13(20)3-4-15(12)21/h3-4,9,11H,5-8,10H2,1-2H3 UFBZNKNUYLJWGY-UHFFFAOYSA-N 50533021 CHEMBL4559230 P2X purinoceptor 3 Homo sapiens 280 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533021 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533021&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155558024 440741603 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315820 CN(C)S(=O)(=O)N1CCc2c(C1)sc1ncn(CCc3ccccc3OC(F)(F)F)c(=O)c21 InChI=1S/C20H21F3N4O4S2/c1-25(2)33(29,30)27-10-8-14-16(11-27)32-18-17(14)19(28)26(12-24-18)9-7-13-5-3-4-6-15(13)31-20(21,22)23/h3-6,12H,7-11H2,1-2H3 RKGWXYCRRYVGMM-UHFFFAOYSA-N 50532990 CHEMBL4453198 P2X purinoceptor 3 Homo sapiens 180 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50532990 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50532990&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155523291 440741572 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315821 COc1ccc(N)c(CCn2cnc3sc4CN(CCc4c3c2=O)S(=O)(=O)N(C)C)c1 InChI=1S/C20H25N5O4S2/c1-23(2)31(27,28)25-9-7-15-17(11-25)30-19-18(15)20(26)24(12-22-19)8-6-13-10-14(29-3)4-5-16(13)21/h4-5,10,12H,6-9,11,21H2,1-3H3 IXQIBBWXERJYOL-UHFFFAOYSA-N 50533022 CHEMBL4550891 P2X purinoceptor 3 Homo sapiens 7300 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533022 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533022&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155555213 440741604 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315822 COc1cc(CCn2cnc3sc4CC5(CCc4c3c2=O)OCCO5)cc(OC)c1 InChI=1S/C22H24N2O5S/c1-26-15-9-14(10-16(11-15)27-2)4-6-24-13-23-20-19(21(24)25)17-3-5-22(12-18(17)30-20)28-7-8-29-22/h9-11,13H,3-8,12H2,1-2H3 OXACRCNFDQBFED-UHFFFAOYSA-N 50533023 CHEMBL4572174 P2X purinoceptor 3 Homo sapiens 65 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533023 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533023&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155563568 440741605 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315823 COc1cc(CCn2cnc3sc4CC(CCc4c3c2=O)N2CCSC2)cc(OC)c1 InChI=1S/C23H27N3O3S2/c1-28-17-9-15(10-18(12-17)29-2)5-6-25-13-24-22-21(23(25)27)19-4-3-16(11-20(19)31-22)26-7-8-30-14-26/h9-10,12-13,16H,3-8,11,14H2,1-2H3 GEOYUYBTJRDKQT-UHFFFAOYSA-N 50532992 CHEMBL4568398 P2X purinoceptor 3 Homo sapiens 140 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50532992 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50532992&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155560573 440741574 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315824 CCC(=O)N1CCc2c(C1)sc1ncn(CCc3cc(OC)ccc3OC)c(=O)c21 InChI=1S/C22H25N3O4S/c1-4-19(26)24-10-8-16-18(12-24)30-21-20(16)22(27)25(13-23-21)9-7-14-11-15(28-2)5-6-17(14)29-3/h5-6,11,13H,4,7-10,12H2,1-3H3 QOHHZEULBRJCHF-UHFFFAOYSA-N 50533024 CHEMBL4450775 P2X purinoceptor 3 Homo sapiens 35 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533024 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533024&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155521709 440741606 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315825 COc1ccc(OC)c(CCn2cnc3sc4CN(CCc4c3c2=O)C(=O)C(C)C)c1 InChI=1S/C23H27N3O4S/c1-14(2)22(27)25-10-8-17-19(12-25)31-21-20(17)23(28)26(13-24-21)9-7-15-11-16(29-3)5-6-18(15)30-4/h5-6,11,13-14H,7-10,12H2,1-4H3 LSDMZBDLXHEDCE-UHFFFAOYSA-N 50533025 CHEMBL4449004 P2X purinoceptor 3 Homo sapiens 25 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533025 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533025&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155520244 440741607 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315826 COc1ccc(OC)c(CCn2cnc3sc4CN(CCc4c3c2=O)C(=O)C(C)(C)C)c1 InChI=1S/C24H29N3O4S/c1-24(2,3)23(29)26-11-9-17-19(13-26)32-21-20(17)22(28)27(14-25-21)10-8-15-12-16(30-4)6-7-18(15)31-5/h6-7,12,14H,8-11,13H2,1-5H3 SGEDKVGYMLOFQQ-UHFFFAOYSA-N 50532995 CHEMBL4476395 P2X purinoceptor 3 Homo sapiens 10.0 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50532995 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50532995&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155538262 440741577 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315827 COc1cc(CCn2cnc3sc4CN(CCc4c3c2=O)C(=O)C2CCC2)cc(OC)c1 InChI=1S/C24H27N3O4S/c1-30-17-10-15(11-18(12-17)31-2)6-8-27-14-25-22-21(24(27)29)19-7-9-26(13-20(19)32-22)23(28)16-4-3-5-16/h10-12,14,16H,3-9,13H2,1-2H3 YGRCSQQYYZGXNB-UHFFFAOYSA-N 50533026 CHEMBL4549131 P2X purinoceptor 3 Homo sapiens 40 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533026 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533026&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155549544 440741608 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315828 COc1cc(CCn2cnc3sc4CN(CCc4c3c2=O)C(=O)C(C)(F)F)cc(OC)c1 InChI=1S/C22H23F2N3O4S/c1-22(23,24)21(29)26-7-5-16-17(11-26)32-19-18(16)20(28)27(12-25-19)6-4-13-8-14(30-2)10-15(9-13)31-3/h8-10,12H,4-7,11H2,1-3H3 LFGCHJQQRAFMOI-UHFFFAOYSA-N 50532997 CHEMBL4439566 P2X purinoceptor 3 Homo sapiens 15 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50532997 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50532997&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155513864 440741579 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315829 COc1cc(CCn2cnc3sc4CN(CCc4c3c2=O)C(=O)C(F)(F)F)cc(OC)c1 InChI=1S/C21H20F3N3O4S/c1-30-13-7-12(8-14(9-13)31-2)3-5-27-11-25-18-17(19(27)28)15-4-6-26(10-16(15)32-18)20(29)21(22,23)24/h7-9,11H,3-6,10H2,1-2H3 MEFNUCYNHDRJFW-UHFFFAOYSA-N 50532998 CHEMBL4587231 P2X purinoceptor 3 Homo sapiens 15 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50532998 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50532998&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155566512 440741580 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315830 COc1cc(CCn2cnc3sc4CN(CCc4c3c2=O)C(=O)C2(O)CC2)cc(OC)c1 InChI=1S/C23H25N3O5S/c1-30-15-9-14(10-16(11-15)31-2)3-7-26-13-24-20-19(21(26)27)17-4-8-25(12-18(17)32-20)22(28)23(29)5-6-23/h9-11,13,29H,3-8,12H2,1-2H3 BMCFFSJJFOLAMP-UHFFFAOYSA-N 50533027 CHEMBL4440963 P2X purinoceptor 3 Homo sapiens 85 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533027 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533027&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155514822 440741609 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315831 COc1cc(CCn2cnc3sc4CN(CCc4c3c2=O)C(=O)C(C)(C)N)cc(OC)c1 InChI=1S/C23H28N4O4S/c1-23(2,24)22(29)26-8-6-17-18(12-26)32-20-19(17)21(28)27(13-25-20)7-5-14-9-15(30-3)11-16(10-14)31-4/h9-11,13H,5-8,12,24H2,1-4H3 SMAWYIGIHHPHKP-UHFFFAOYSA-N 50533028 CHEMBL4542643 P2X purinoceptor 3 Homo sapiens 640 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533028 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533028&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155551797 440741610 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315832 COc1cc(CCn2cnc3sc4CN(CCc4c3c2=O)S(=O)(=O)C(C)C)cc(OC)c1 InChI=1S/C22H27N3O5S2/c1-14(2)32(27,28)25-8-6-18-19(12-25)31-21-20(18)22(26)24(13-23-21)7-5-15-9-16(29-3)11-17(10-15)30-4/h9-11,13-14H,5-8,12H2,1-4H3 IQVVCHNHPMBALO-UHFFFAOYSA-N 50533029 CHEMBL4448484 P2X purinoceptor 3 Homo sapiens 20 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533029 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533029&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155519826 440741611 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315833 COc1cc(CCn2cnc3sc4CN(CCc4c3c2=O)S(=O)(=O)C2CCCC2)cc(OC)c1 InChI=1S/C24H29N3O5S2/c1-31-17-11-16(12-18(13-17)32-2)7-9-26-15-25-23-22(24(26)28)20-8-10-27(14-21(20)33-23)34(29,30)19-5-3-4-6-19/h11-13,15,19H,3-10,14H2,1-2H3 VXBOFAACMMKOEG-UHFFFAOYSA-N 50533002 CHEMBL4440083 P2X purinoceptor 3 Homo sapiens 40 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533002 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533002&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155514547 440741584 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315834 CCOC(=O)C1CCc2c(C1)sc1ncn(CCc3cc(OC)ccc3OC)c(=O)c21 InChI=1S/C23H26N2O5S/c1-4-30-23(27)15-5-7-17-19(12-15)31-21-20(17)22(26)25(13-24-21)10-9-14-11-16(28-2)6-8-18(14)29-3/h6,8,11,13,15H,4-5,7,9-10,12H2,1-3H3 YESOMKWNPIOVSW-UHFFFAOYSA-N 50533003 CHEMBL4547802 P2X purinoceptor 3 Homo sapiens 48 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533003 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533003&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155553704 440741585 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315835 COc1ccc(OC)c(CCn2cnc3sc4C[C@H](CCc4c3c2=O)C(=O)N(C)C)c1 InChI=1S/C23H27N3O4S/c1-25(2)22(27)15-5-7-17-19(12-15)31-21-20(17)23(28)26(13-24-21)10-9-14-11-16(29-3)6-8-18(14)30-4/h6,8,11,13,15H,5,7,9-10,12H2,1-4H3/t15-/m0/s1 FZCDZTJYZBKDBO-HNNXBMFYSA-N 50533030 CHEMBL4568965 P2X purinoceptor 3 Homo sapiens 21 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533030 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533030&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155550268 440741612 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315837 COc1ccccc1CCn1cnc2sc3CN(CCc3c2c1=O)C(=O)N1CCCCC1 InChI=1S/C24H28N4O3S/c1-31-19-8-4-3-7-17(19)9-13-28-16-25-22-21(23(28)29)18-10-14-27(15-20(18)32-22)24(30)26-11-5-2-6-12-26/h3-4,7-8,16H,2,5-6,9-15H2,1H3 XWXIOAXTGNZPSR-UHFFFAOYSA-N 50533031 CHEMBL4471019 P2X purinoceptor 3 Homo sapiens 2100 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533031 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533031&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155534904 440741613 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315838 COc1ccccc1CCn1cnc2sc3CN(CCc3c2c1=O)C(=O)NC(C)(C)C InChI=1S/C23H28N4O3S/c1-23(2,3)25-22(29)26-12-10-16-18(13-26)31-20-19(16)21(28)27(14-24-20)11-9-15-7-5-6-8-17(15)30-4/h5-8,14H,9-13H2,1-4H3,(H,25,29) HGJQSFLUTRUQJU-UHFFFAOYSA-N 50532980 CHEMBL4515211 P2X purinoceptor 3 Homo sapiens 7500 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50532980 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50532980&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 42795663 440741562 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315839 COc1ccc(CCn2cnc3sc4CN(CCc4c3c2=O)C(=O)OC(C)(C)C)cc1 InChI=1S/C23H27N3O4S/c1-23(2,3)30-22(28)25-12-10-17-18(13-25)31-20-19(17)21(27)26(14-24-20)11-9-15-5-7-16(29-4)8-6-15/h5-8,14H,9-13H2,1-4H3 ZPLPMPLPZHYFAM-UHFFFAOYSA-N 50532983 CHEMBL4440709 P2X purinoceptor 3 Homo sapiens 7500 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50532983 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50532983&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155514869 440741565 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315840 COc1ccccc1CCCn1cnc2sc3CN(CCc3c2c1=O)C(=O)OC(C)(C)C InChI=1S/C24H29N3O4S/c1-24(2,3)31-23(29)26-13-11-17-19(14-26)32-21-20(17)22(28)27(15-25-21)12-7-9-16-8-5-6-10-18(16)30-4/h5-6,8,10,15H,7,9,11-14H2,1-4H3 INHCHXDLEAVPGY-UHFFFAOYSA-N 50532972 CHEMBL4458523 P2X purinoceptor 3 Homo sapiens 7500 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50532972 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50532972&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155526369 440741554 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315841 C[C@H](CN1CCN(CC1)C(C)=O)NC(=O)c1cc2c(nn(C)c2s1)-c1ccccc1 InChI=1S/C22H27N5O2S/c1-15(14-26-9-11-27(12-10-26)16(2)28)23-21(29)19-13-18-20(17-7-5-4-6-8-17)24-25(3)22(18)30-19/h4-8,13,15H,9-12,14H2,1-3H3,(H,23,29)/t15-/m1/s1 WLMBSKSEPQCRJV-OAHLLOKOSA-N 50415550 CHEMBL599760::Ro-85 P2X purinoceptor 3 Homo sapiens 2400 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50415550 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50415550&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 46175179 163364574 CHEMBL599760 ZINC45357437 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315842 COc1ccc(OC)c(CCn2cnc3sc4CN(CCc4c3c2=O)S(=O)(=O)N(C)C)c1 InChI=1S/C21H26N4O5S2/c1-23(2)32(27,28)25-10-8-16-18(12-25)31-20-19(16)21(26)24(13-22-20)9-7-14-11-15(29-3)5-6-17(14)30-4/h5-6,11,13H,7-10,12H2,1-4H3 VTJCBRSDHQACLF-UHFFFAOYSA-N 50532987 CHEMBL4458821 P2X purinoceptor 3 Homo sapiens 20 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50532987 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50532987&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155526703 440741569 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315843 COc1ccc(Cl)cc1CCn1cnc2sc3CN(CCc3c2c1=O)S(=O)(=O)N(C)C InChI=1S/C20H23ClN4O4S2/c1-23(2)31(27,28)25-9-7-15-17(11-25)30-19-18(15)20(26)24(12-22-19)8-6-13-10-14(21)4-5-16(13)29-3/h4-5,10,12H,6-9,11H2,1-3H3 ZCCYHYVRGKVMEH-UHFFFAOYSA-N 50532989 CHEMBL4442508 P2X purinoceptor 3 Homo sapiens 35 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50532989 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50532989&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155515950 440741571 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315844 COc1cc(CCn2cnc3sc4CN(CCc4c3c2=O)S(N)(=O)=O)cc(OC)c1 InChI=1S/C19H22N4O5S2/c1-27-13-7-12(8-14(9-13)28-2)3-5-22-11-21-18-17(19(22)24)15-4-6-23(30(20,25)26)10-16(15)29-18/h7-9,11H,3-6,10H2,1-2H3,(H2,20,25,26) YPILIMJLSMUQTA-UHFFFAOYSA-N 50532991 CHEMBL4463088 P2X purinoceptor 3 Homo sapiens 650 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50532991 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50532991&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155529657 440741573 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315845 COc1ccc(OC)c(CCn2cnc3sc4CN(CCc4c3c2=O)C(C)=O)c1 InChI=1S/C21H23N3O4S/c1-13(25)23-9-7-16-18(11-23)29-20-19(16)21(26)24(12-22-20)8-6-14-10-15(27-2)4-5-17(14)28-3/h4-5,10,12H,6-9,11H2,1-3H3 SMIWFLCSKIEXDF-UHFFFAOYSA-N 50532994 CHEMBL4565455 P2X purinoceptor 3 Homo sapiens 140 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50532994 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50532994&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155544746 440741576 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315846 COc1cc(CCn2cnc3sc4CN(CCc4c3c2=O)S(=O)(=O)N2CCCCC2)cc(OC)c1 InChI=1S/C24H30N4O5S2/c1-32-18-12-17(13-19(14-18)33-2)6-10-26-16-25-23-22(24(26)29)20-7-11-28(15-21(20)34-23)35(30,31)27-8-4-3-5-9-27/h12-14,16H,3-11,15H2,1-2H3 VUXCMRQCCAQUJU-UHFFFAOYSA-N 50533014 CHEMBL4559858 P2X purinoceptor 3 Homo sapiens 150 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533014 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533014&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155557786 440741596 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315847 COc1ccccc1CCn1cnc2sc3CN(CCc3c2c1=O)C(=O)N1CCCC1 InChI=1S/C23H26N4O3S/c1-30-18-7-3-2-6-16(18)8-12-27-15-24-21-20(22(27)28)17-9-13-26(14-19(17)31-21)23(29)25-10-4-5-11-25/h2-3,6-7,15H,4-5,8-14H2,1H3 REQFVEBVRQSIBC-UHFFFAOYSA-N 50533015 CHEMBL4557380 P2X purinoceptor 3 Homo sapiens 1600 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533015 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533015&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155554392 440741597 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315848 COc1cccc(CCn2cnc3sc4CN(CCc4c3c2=O)C(=O)OC(C)(C)C)c1OC InChI=1S/C24H29N3O5S/c1-24(2,3)32-23(29)26-12-10-16-18(13-26)33-21-19(16)22(28)27(14-25-21)11-9-15-7-6-8-17(30-4)20(15)31-5/h6-8,14H,9-13H2,1-5H3 IIMWZHNSMXZLPX-UHFFFAOYSA-N 50533016 CHEMBL4460309 P2X purinoceptor 3 Homo sapiens 2400 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533016 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533016&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155527693 440741598 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315849 COc1cccc(CCn2cnc3sc4CN(CCc4c3c2=O)C(=O)OC(C)(C)C)c1 InChI=1S/C23H27N3O4S/c1-23(2,3)30-22(28)25-11-9-17-18(13-25)31-20-19(17)21(27)26(14-24-20)10-8-15-6-5-7-16(12-15)29-4/h5-7,12,14H,8-11,13H2,1-4H3 VGMWBFAAPZXVTP-UHFFFAOYSA-N 50533017 CHEMBL4520865 P2X purinoceptor 3 Homo sapiens 3700 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533017 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533017&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155542440 440741599 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315850 COc1ccccc1CCn1cnc2sc3CN(CCc3c2c1=O)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C24H22FN3O4S2/c1-32-20-5-3-2-4-16(20)10-12-27-15-26-23-22(24(27)29)19-11-13-28(14-21(19)33-23)34(30,31)18-8-6-17(25)7-9-18/h2-9,15H,10-14H2,1H3 IFSYYEGWQCBGLX-UHFFFAOYSA-N 50533019 CHEMBL4589123 P2X purinoceptor 3 Homo sapiens 840 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533019 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533019&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 134691714 440741601 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315851 COc1cc(C(C)C)c(Oc2cnc(N)nc2N)cc1I InChI=1S/C14H17IN4O2/c1-7(2)8-4-11(20-3)9(15)5-10(8)21-12-6-18-14(17)19-13(12)16/h4-7H,1-3H3,(H4,16,17,18,19) AATPYXMXFBBKFO-UHFFFAOYSA-N 50257636 5-(5-iodo-2-isopropyl-4-methoxyphenoxy)pyrimidine-2,4-diamine::CHEMBL526307 P2X purinoceptor 3 Homo sapiens 20 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50257636 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50257636&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 15953802 104108644 CHEMBL526307 ZINC34809174 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315852 COc1ccc(OC)c(CCn2c(C)nc3sc4CN(CCc4c3c2=O)S(=O)(=O)N(C)C)c1 InChI=1S/C22H28N4O5S2/c1-14-23-21-20(17-9-10-25(13-19(17)32-21)33(28,29)24(2)3)22(27)26(14)11-8-15-12-16(30-4)6-7-18(15)31-5/h6-7,12H,8-11,13H2,1-5H3 NZIQAORIXMWZQC-UHFFFAOYSA-N 50533032 CHEMBL4459425 P2X purinoceptor 3 Homo sapiens 590 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533032 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533032&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155526972 440741614 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315853 CN(C)S(=O)(=O)N1CCc2c(C1)sc1ncn(CCc3cc(Cl)ccc3Cl)c(=O)c21 InChI=1S/C19H20Cl2N4O3S2/c1-23(2)30(27,28)25-8-6-14-16(10-25)29-18-17(14)19(26)24(11-22-18)7-5-12-9-13(20)3-4-15(12)21/h3-4,9,11H,5-8,10H2,1-2H3 UFBZNKNUYLJWGY-UHFFFAOYSA-N 50533021 CHEMBL4559230 P2X purinoceptor 3 Homo sapiens 280 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533021 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533021&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155558024 440741603 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315854 COc1cc(CCn2cnc3sc4CC5(CCc4c3c2=O)OCCO5)cc(OC)c1 InChI=1S/C22H24N2O5S/c1-26-15-9-14(10-16(11-15)27-2)4-6-24-13-23-20-19(21(24)25)17-3-5-22(12-18(17)30-20)28-7-8-29-22/h9-11,13H,3-8,12H2,1-2H3 OXACRCNFDQBFED-UHFFFAOYSA-N 50533023 CHEMBL4572174 P2X purinoceptor 3 Homo sapiens 65 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533023 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533023&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155563568 440741605 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315855 COc1ccc(OC)c(CCn2cnc3sc4CN(CCc4c3c2=O)C(=O)C(C)C)c1 InChI=1S/C23H27N3O4S/c1-14(2)22(27)25-10-8-17-19(12-25)31-21-20(17)23(28)26(13-24-21)9-7-15-11-16(29-3)5-6-18(15)30-4/h5-6,11,13-14H,7-10,12H2,1-4H3 LSDMZBDLXHEDCE-UHFFFAOYSA-N 50533025 CHEMBL4449004 P2X purinoceptor 3 Homo sapiens 25 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533025 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533025&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155520244 440741607 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315856 COc1cc(CCn2cnc3sc4CN(CCc4c3c2=O)C(=O)C2CCC2)cc(OC)c1 InChI=1S/C24H27N3O4S/c1-30-17-10-15(11-18(12-17)31-2)6-8-27-14-25-22-21(24(27)29)19-7-9-26(13-20(19)32-22)23(28)16-4-3-5-16/h10-12,14,16H,3-9,13H2,1-2H3 YGRCSQQYYZGXNB-UHFFFAOYSA-N 50533026 CHEMBL4549131 P2X purinoceptor 3 Homo sapiens 40 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533026 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533026&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155549544 440741608 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315857 COc1cc(CCn2cnc3sc4CN(CCc4c3c2=O)C(=O)C2(O)CC2)cc(OC)c1 InChI=1S/C23H25N3O5S/c1-30-15-9-14(10-16(11-15)31-2)3-7-26-13-24-20-19(21(26)27)17-4-8-25(12-18(17)32-20)22(28)23(29)5-6-23/h9-11,13,29H,3-8,12H2,1-2H3 BMCFFSJJFOLAMP-UHFFFAOYSA-N 50533027 CHEMBL4440963 P2X purinoceptor 3 Homo sapiens 85 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533027 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533027&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155514822 440741609 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315858 COc1cc(CCn2cnc3sc4CN(CCc4c3c2=O)S(=O)(=O)C(C)C)cc(OC)c1 InChI=1S/C22H27N3O5S2/c1-14(2)32(27,28)25-8-6-18-19(12-25)31-21-20(18)22(26)24(13-23-21)7-5-15-9-16(29-3)11-17(10-15)30-4/h9-11,13-14H,5-8,12H2,1-4H3 IQVVCHNHPMBALO-UHFFFAOYSA-N 50533029 CHEMBL4448484 P2X purinoceptor 3 Homo sapiens 20 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533029 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533029&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155519826 440741611 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315859 COc1ccc(OC)c(CCn2cnc3sc4C[C@H](CCc4c3c2=O)C(=O)N(C)C)c1 InChI=1S/C23H27N3O4S/c1-25(2)22(27)15-5-7-17-19(12-15)31-21-20(17)23(28)26(13-24-21)10-9-14-11-16(29-3)6-8-18(14)30-4/h6,8,11,13,15H,5,7,9-10,12H2,1-4H3/t15-/m0/s1 FZCDZTJYZBKDBO-HNNXBMFYSA-N 50533030 CHEMBL4568965 P2X purinoceptor 3 Homo sapiens 21 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533030 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533030&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155550268 440741612 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315860 CCC(C)(C)C(=O)N1CCc2c(C1)sc1ncn(CCc3cc(OC)cc(OC)c3)c(=O)c21 InChI=1S/C25H31N3O4S/c1-6-25(2,3)24(30)27-10-8-19-20(14-27)33-22-21(19)23(29)28(15-26-22)9-7-16-11-17(31-4)13-18(12-16)32-5/h11-13,15H,6-10,14H2,1-5H3 NJVGOSUDSKLXFI-UHFFFAOYSA-N 50532996 CHEMBL4542098 P2X purinoceptor 3 Homo sapiens 15 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50532996 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50532996&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155551563 440741578 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315861 COc1cc(CCn2cnc3sc4CN(CCc4c3c2=O)C(=O)CO)cc(OC)c1 InChI=1S/C21H23N3O5S/c1-28-14-7-13(8-15(9-14)29-2)3-5-24-12-22-20-19(21(24)27)16-4-6-23(18(26)11-25)10-17(16)30-20/h7-9,12,25H,3-6,10-11H2,1-2H3 VKBGJWSZBAWKII-UHFFFAOYSA-N 50532999 CHEMBL4451343 P2X purinoceptor 3 Homo sapiens 180 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50532999 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50532999&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155521633 440741581 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315862 COc1cc(CCn2cnc3sc4CN(CCc4c3c2=O)S(C)(=O)=O)cc(OC)c1 InChI=1S/C20H23N3O5S2/c1-27-14-8-13(9-15(10-14)28-2)4-6-22-12-21-19-18(20(22)24)16-5-7-23(30(3,25)26)11-17(16)29-19/h8-10,12H,4-7,11H2,1-3H3 GQQMAFKUBRMNLZ-UHFFFAOYSA-N 50533001 CHEMBL4515308 P2X purinoceptor 3 Homo sapiens 40 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533001 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533001&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155540008 440741583 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315863 COc1ccc(OC)c(CCn2cnc3sc4CC(CCc4c3c2=O)C(=O)N(C)C)c1 InChI=1S/C23H27N3O4S/c1-25(2)22(27)15-5-7-17-19(12-15)31-21-20(17)23(28)26(13-24-21)10-9-14-11-16(29-3)6-8-18(14)30-4/h6,8,11,13,15H,5,7,9-10,12H2,1-4H3 FZCDZTJYZBKDBO-UHFFFAOYSA-N 50533004 CHEMBL4546396 P2X purinoceptor 3 Homo sapiens 33 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533004 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533004&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155552357 440741586 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315864 COc1ccccc1CCn1cnc2sc3CN(CCc3c2c1=O)C(=O)N1CCCCC1 InChI=1S/C24H28N4O3S/c1-31-19-8-4-3-7-17(19)9-13-28-16-25-22-21(23(28)29)18-10-14-27(15-20(18)32-22)24(30)26-11-5-2-6-12-26/h3-4,7-8,16H,2,5-6,9-15H2,1H3 XWXIOAXTGNZPSR-UHFFFAOYSA-N 50533031 CHEMBL4471019 P2X purinoceptor 3 Homo sapiens 2100 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533031 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533031&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155534904 440741613 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315865 COc1ccccc1Cn1cnc2sc3CN(CCc3c2c1=O)C(=O)OC(C)(C)C InChI=1S/C22H25N3O4S/c1-22(2,3)29-21(27)24-10-9-15-17(12-24)30-19-18(15)20(26)25(13-23-19)11-14-7-5-6-8-16(14)28-4/h5-8,13H,9-12H2,1-4H3 YWRHPUXMSHPQKV-UHFFFAOYSA-N 50533018 CHEMBL4436079 P2X purinoceptor 3 Homo sapiens 6300 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533018 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533018&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155511587 440741600 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315866 COc1ccc(OC)c(c1)C(C)Cn1cnc2sc3CN(CCc3c2c1=O)S(=O)(=O)N(C)C InChI=1S/C22H28N4O5S2/c1-14(17-10-15(30-4)6-7-18(17)31-5)11-25-13-23-21-20(22(25)27)16-8-9-26(12-19(16)32-21)33(28,29)24(2)3/h6-7,10,13-14H,8-9,11-12H2,1-5H3 BCABBMIXRDTMRE-UHFFFAOYSA-N 50533020 CHEMBL4558507 P2X purinoceptor 3 Homo sapiens 1400 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533020 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533020&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155557542 440741602 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315867 CCC(=O)N1CCc2c(C1)sc1ncn(CCc3cc(OC)ccc3OC)c(=O)c21 InChI=1S/C22H25N3O4S/c1-4-19(26)24-10-8-16-18(12-24)30-21-20(16)22(27)25(13-23-21)9-7-14-11-15(28-2)5-6-17(14)29-3/h5-6,11,13H,4,7-10,12H2,1-3H3 QOHHZEULBRJCHF-UHFFFAOYSA-N 50533024 CHEMBL4450775 P2X purinoceptor 3 Homo sapiens 35 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533024 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533024&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155521709 440741606 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315868 COc1cc(CCn2cnc3sc4CN(CCc4c3c2=O)C(=O)C(C)(C)N)cc(OC)c1 InChI=1S/C23H28N4O4S/c1-23(2,24)22(29)26-8-6-17-18(12-26)32-20-19(17)21(28)27(13-25-20)7-5-14-9-15(30-3)11-16(10-14)31-4/h9-11,13H,5-8,12,24H2,1-4H3 SMAWYIGIHHPHKP-UHFFFAOYSA-N 50533028 CHEMBL4542643 P2X purinoceptor 3 Homo sapiens 640 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533028 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533028&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155551797 440741610 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315869 COc1ccc(N)c(CCn2cnc3sc4CN(CCc4c3c2=O)S(=O)(=O)N(C)C)c1 InChI=1S/C20H25N5O4S2/c1-23(2)31(27,28)25-9-7-15-17(11-25)30-19-18(15)20(26)24(12-22-19)8-6-13-10-14(29-3)4-5-16(13)21/h4-5,10,12H,6-9,11,21H2,1-3H3 IXQIBBWXERJYOL-UHFFFAOYSA-N 50533022 CHEMBL4550891 P2X purinoceptor 3 Homo sapiens 7300 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533022 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533022&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155555213 440741604 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315870 COc1cc(C(C)C)c(Oc2cnc(N)nc2N)cc1S(N)(=O)=O InChI=1S/C14H19N5O4S/c1-7(2)8-4-10(22-3)12(24(17,20)21)5-9(8)23-11-6-18-14(16)19-13(11)15/h4-7H,1-3H3,(H2,17,20,21)(H4,15,16,18,19) HLWURFKMDLAKOD-UHFFFAOYSA-N 50533006 Af-219::Gefapixant::R-1646::R1646::RG-1646::RG1646::RO-4926219::RO4926219 P2X purinoceptor 3 Homo sapiens 45 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533006 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533006&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search AF9 5YVE 24764487 440741588 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315871 COc1ccc(OC)c(CC(C)n2cnc3sc4CN(CCc4c3c2=O)S(=O)(=O)N(C)C)c1 InChI=1S/C22H28N4O5S2/c1-14(10-15-11-16(30-4)6-7-18(15)31-5)26-13-23-21-20(22(26)27)17-8-9-25(12-19(17)32-21)33(28,29)24(2)3/h6-7,11,13-14H,8-10,12H2,1-5H3 MQSYMKAYRWSBQB-UHFFFAOYSA-N 50532988 CHEMBL4590779 P2X purinoceptor 3 Homo sapiens 3300 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50532988 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50532988&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155568671 440741570 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315872 COc1ccccc1CCn1cnc2sc3CN(CCc3c2c1=O)C(=O)N1CCOCC1 InChI=1S/C23H26N4O4S/c1-30-18-5-3-2-4-16(18)6-8-27-15-24-21-20(22(27)28)17-7-9-26(14-19(17)32-21)23(29)25-10-12-31-13-11-25/h2-5,15H,6-14H2,1H3 UIXFHCMVAQPTDF-UHFFFAOYSA-N 50532978 CHEMBL4589553 P2X purinoceptor 3 Homo sapiens 3800 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50532978 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50532978&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155567668 440741560 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315873 CC(C)(C)OC(=O)N1CCc2c(C1)sc1ncn(CCc3ccccc3F)c(=O)c21 InChI=1S/C22H24FN3O3S/c1-22(2,3)29-21(28)25-11-9-15-17(12-25)30-19-18(15)20(27)26(13-24-19)10-8-14-6-4-5-7-16(14)23/h4-7,13H,8-12H2,1-3H3 VAFSGKMNCAMINP-UHFFFAOYSA-N 50532984 CHEMBL4469946 P2X purinoceptor 3 Homo sapiens 5000 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50532984 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50532984&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155534154 440741566 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315874 COc1ccc(OC)c(CCn2c(C)nc3sc4CN(CCc4c3c2=O)S(=O)(=O)N(C)C)c1 InChI=1S/C22H28N4O5S2/c1-14-23-21-20(17-9-10-25(13-19(17)32-21)33(28,29)24(2)3)22(27)26(14)11-8-15-12-16(30-4)6-7-18(15)31-5/h6-7,12H,8-11,13H2,1-5H3 NZIQAORIXMWZQC-UHFFFAOYSA-N 50533032 CHEMBL4459425 P2X purinoceptor 3 Homo sapiens 590 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533032 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533032&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155526972 440741614 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315875 COc1cc(CCn2cnc3sc4CS(=O)(=O)CCc4c3c2=O)cc(OC)c1 InChI=1S/C19H20N2O5S2/c1-25-13-7-12(8-14(9-13)26-2)3-5-21-11-20-18-17(19(21)22)15-4-6-28(23,24)10-16(15)27-18/h7-9,11H,3-6,10H2,1-2H3 SELGQMNEAIRGJD-UHFFFAOYSA-N 50532993 CHEMBL4571607 P2X purinoceptor 3 Homo sapiens 1300 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50532993 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50532993&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155562606 440741575 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315876 COc1cc(CCn2cnc3sc4CN(CCc4c3c2=O)C(=O)CN(C)C)cc(OC)c1 InChI=1S/C23H28N4O4S/c1-25(2)13-20(28)26-8-6-18-19(12-26)32-22-21(18)23(29)27(14-24-22)7-5-15-9-16(30-3)11-17(10-15)31-4/h9-11,14H,5-8,12-13H2,1-4H3 HQHFILMGEBTBTN-UHFFFAOYSA-N 50533000 CHEMBL4578016 P2X purinoceptor 3 Homo sapiens 1000 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533000 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533000&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155564816 440741582 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315878 COc1ccc(OC)c(CCOc2ncnc3sc4CN(CCc4c23)S(=O)(=O)N(C)C)c1 InChI=1S/C21H26N4O5S2/c1-24(2)32(26,27)25-9-7-16-18(12-25)31-21-19(16)20(22-13-23-21)30-10-8-14-11-15(28-3)5-6-17(14)29-4/h5-6,11,13H,7-10,12H2,1-4H3 XFQIQNBCLGRSFE-UHFFFAOYSA-N 50533007 CHEMBL4463658 P2X purinoceptor 3 Homo sapiens 7400 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533007 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533007&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155530178 440741589 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315879 COc1cc(CCn2cnc3sc4CN(CCc4c3c2=O)C(=O)C(C)(C)O)cc(OC)c1 InChI=1S/C23H27N3O5S/c1-23(2,29)22(28)25-8-6-17-18(12-25)32-20-19(17)21(27)26(13-24-20)7-5-14-9-15(30-3)11-16(10-14)31-4/h9-11,13,29H,5-8,12H2,1-4H3 HAXTZLKLKPSLQF-UHFFFAOYSA-N 50533010 CHEMBL4563035 P2X purinoceptor 3 Homo sapiens 55 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533010 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533010&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155559341 440741592 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315880 CC(C)(C)OC(=O)N1CCc2c(C1)sc1ncn(CCc3ccccc3[N+]([O-])=O)c(=O)c21 InChI=1S/C22H24N4O5S/c1-22(2,3)31-21(28)24-11-9-15-17(12-24)32-19-18(15)20(27)25(13-23-19)10-8-14-6-4-5-7-16(14)26(29)30/h4-7,13H,8-12H2,1-3H3 FLLPYBKYUHJJGN-UHFFFAOYSA-N 50533012 CHEMBL4549156 P2X purinoceptor 3 Homo sapiens 5700 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533012 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533012&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155548909 440741594 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315881 COc1cc(CCn2cnc3sc4CC(=O)CCc4c3c2=O)cc(OC)c1 InChI=1S/C20H20N2O4S/c1-25-14-7-12(8-15(10-14)26-2)5-6-22-11-21-19-18(20(22)24)16-4-3-13(23)9-17(16)27-19/h7-8,10-11H,3-6,9H2,1-2H3 LOPOSNPJGIWCBF-UHFFFAOYSA-N 50533013 CHEMBL4565351 P2X purinoceptor 3 Homo sapiens 6800 ChEMBL 10.1016/j.bmcl.2016.07.009 10.7270/Q26W9FJD 27423478 Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533013 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533013&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155544725 440741595 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315882 COc1ccc(OC)c(CCn2cnc3ccc(cc3c2=O)-c2ccccc2C(N)=O)c1 InChI=1S/C25H23N3O4/c1-31-18-8-10-23(32-2)17(13-18)11-12-28-15-27-22-9-7-16(14-21(22)25(28)30)19-5-3-4-6-20(19)24(26)29/h3-10,13-15H,11-12H2,1-2H3,(H2,26,29) UQTCIGRTDYHCQD-UHFFFAOYSA-N 50533033 CHEMBL4577151 P2X purinoceptor 3 Homo sapiens 190 ChEMBL 10.1016/j.bmcl.2016.07.013 10.7270/Q2348PWW 27426300 Szántó, G; Makó, A; Vágó, I; Hergert, T; Bata, I; Farkas, B; Kolok, S; Vastag, M Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533033 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533033&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155553879 440741615 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315883 COc1cc(CCn2cnc3ccc(cc3c2=O)-c2cn[nH]c2C)cc(OC)c1 InChI=1S/C22H22N4O3/c1-14-20(12-24-25-14)16-4-5-21-19(10-16)22(27)26(13-23-21)7-6-15-8-17(28-2)11-18(9-15)29-3/h4-5,8-13H,6-7H2,1-3H3,(H,24,25) DUUJSMLVHYPUNZ-UHFFFAOYSA-N 50533034 CHEMBL4557775 P2X purinoceptor 3 Homo sapiens 80 ChEMBL 10.1016/j.bmcl.2016.07.013 10.7270/Q2348PWW 27426300 Szántó, G; Makó, A; Vágó, I; Hergert, T; Bata, I; Farkas, B; Kolok, S; Vastag, M Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533034 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533034&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155554473 440741616 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315884 CC(C)N1Cc2c(nc(nc2NC(C)(C)Cc2ccc(Cl)cc2)N2CCN(CC2)C(C)=O)C1=O InChI=1S/C25H33ClN6O2/c1-16(2)32-15-20-21(23(32)34)27-24(31-12-10-30(11-13-31)17(3)33)28-22(20)29-25(4,5)14-18-6-8-19(26)9-7-18/h6-9,16H,10-15H2,1-5H3,(H,27,28,29) QPDPLVXCWWSXFN-UHFFFAOYSA-N 50379707 CHEMBL2011112 P2X purinoceptor 3 Homo sapiens 20 ChEMBL 10.1016/j.bmcl.2016.07.013 10.7270/Q2348PWW 27426300 Szántó, G; Makó, A; Vágó, I; Hergert, T; Bata, I; Farkas, B; Kolok, S; Vastag, M Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50379707 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50379707&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 25122581 160858790 CHEMBL2011112 ZINC68247086 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315885 COc1ccc(OC)c(CCn2cnc3ccc(cc3c2=O)-c2ccccc2C(N)=O)c1 InChI=1S/C25H23N3O4/c1-31-18-8-10-23(32-2)17(13-18)11-12-28-15-27-22-9-7-16(14-21(22)25(28)30)19-5-3-4-6-20(19)24(26)29/h3-10,13-15H,11-12H2,1-2H3,(H2,26,29) UQTCIGRTDYHCQD-UHFFFAOYSA-N 50533033 CHEMBL4577151 P2X purinoceptor 3 Homo sapiens 190 ChEMBL 10.1016/j.bmcl.2016.07.013 10.7270/Q2348PWW 27426300 Szántó, G; Makó, A; Vágó, I; Hergert, T; Bata, I; Farkas, B; Kolok, S; Vastag, M Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533033 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533033&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155553879 440741615 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315886 COc1cc(CCn2cnc3ccc(cc3c2=O)-c2cn[nH]c2C)cc(OC)c1 InChI=1S/C22H22N4O3/c1-14-20(12-24-25-14)16-4-5-21-19(10-16)22(27)26(13-23-21)7-6-15-8-17(28-2)11-18(9-15)29-3/h4-5,8-13H,6-7H2,1-3H3,(H,24,25) DUUJSMLVHYPUNZ-UHFFFAOYSA-N 50533034 CHEMBL4557775 P2X purinoceptor 3 Homo sapiens 80 ChEMBL 10.1016/j.bmcl.2016.07.013 10.7270/Q2348PWW 27426300 Szántó, G; Makó, A; Vágó, I; Hergert, T; Bata, I; Farkas, B; Kolok, S; Vastag, M Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533034 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533034&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155554473 440741616 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315887 CC(C)N1Cc2c(nc(nc2NC(C)(C)Cc2ccc(Cl)cc2)N2CCN(CC2)C(C)=O)C1=O InChI=1S/C25H33ClN6O2/c1-16(2)32-15-20-21(23(32)34)27-24(31-12-10-30(11-13-31)17(3)33)28-22(20)29-25(4,5)14-18-6-8-19(26)9-7-18/h6-9,16H,10-15H2,1-5H3,(H,27,28,29) QPDPLVXCWWSXFN-UHFFFAOYSA-N 50379707 CHEMBL2011112 P2X purinoceptor 3 Homo sapiens 20 ChEMBL 10.1016/j.bmcl.2016.07.013 10.7270/Q2348PWW 27426300 Szántó, G; Makó, A; Vágó, I; Hergert, T; Bata, I; Farkas, B; Kolok, S; Vastag, M Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50379707 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50379707&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 25122581 160858790 CHEMBL2011112 ZINC68247086 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315888 COc1ccc(OC)c(CCn2cnc3ccc(cc3c2=O)-c2ccc(N)nc2C)c1 InChI=1S/C24H24N4O3/c1-15-19(6-9-23(25)27-15)16-4-7-21-20(13-16)24(29)28(14-26-21)11-10-17-12-18(30-2)5-8-22(17)31-3/h4-9,12-14H,10-11H2,1-3H3,(H2,25,27) LQRBEFQGUWALRR-UHFFFAOYSA-N 50533035 CHEMBL4521422 P2X purinoceptor 3 Homo sapiens 7.0 ChEMBL 10.1016/j.bmcl.2016.07.013 10.7270/Q2348PWW 27426300 Szántó, G; Makó, A; Vágó, I; Hergert, T; Bata, I; Farkas, B; Kolok, S; Vastag, M Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533035 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533035&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155542766 440741617 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315889 COc1ccc(OC)c(CCn2cnc3ccc(cc3c2=O)-c2ccc(NC(C)=O)cc2OC)c1 InChI=1S/C27H27N3O5/c1-17(31)29-20-6-8-22(26(15-20)35-4)18-5-9-24-23(14-18)27(32)30(16-28-24)12-11-19-13-21(33-2)7-10-25(19)34-3/h5-10,13-16H,11-12H2,1-4H3,(H,29,31) QIUZDABWOLZPEX-UHFFFAOYSA-N 50533036 CHEMBL4456466 P2X purinoceptor 3 Homo sapiens 5.0 ChEMBL 10.1016/j.bmcl.2016.07.013 10.7270/Q2348PWW 27426300 Szántó, G; Makó, A; Vágó, I; Hergert, T; Bata, I; Farkas, B; Kolok, S; Vastag, M Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533036 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533036&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155524530 440741618 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315890 COc1ccc(OC)c(CCn2cnc3ccc(cc3c2=O)-c2ccc(N)cc2OC)c1 InChI=1S/C25H25N3O4/c1-30-19-6-9-23(31-2)17(12-19)10-11-28-15-27-22-8-4-16(13-21(22)25(28)29)20-7-5-18(26)14-24(20)32-3/h4-9,12-15H,10-11,26H2,1-3H3 QBDAAIVUYJFOMZ-UHFFFAOYSA-N 50533037 CHEMBL4474615 P2X purinoceptor 3 Homo sapiens 20 ChEMBL 10.1016/j.bmcl.2016.07.013 10.7270/Q2348PWW 27426300 Szántó, G; Makó, A; Vágó, I; Hergert, T; Bata, I; Farkas, B; Kolok, S; Vastag, M Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533037 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533037&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155537072 440741619 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315891 COc1ccc(OC)c(CCn2cnc3ccc(cc3c2=O)-c2ccccc2OC)c1 InChI=1S/C25H24N2O4/c1-29-19-9-11-23(30-2)18(14-19)12-13-27-16-26-22-10-8-17(15-21(22)25(27)28)20-6-4-5-7-24(20)31-3/h4-11,14-16H,12-13H2,1-3H3 LDZAVHOMQUQGBB-UHFFFAOYSA-N 50533038 CHEMBL4577427 P2X purinoceptor 3 Homo sapiens 45 ChEMBL 10.1016/j.bmcl.2016.07.013 10.7270/Q2348PWW 27426300 Szántó, G; Makó, A; Vágó, I; Hergert, T; Bata, I; Farkas, B; Kolok, S; Vastag, M Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533038 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533038&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155564839 440741620 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315892 COc1ccc(OC)c(CCn2cnc3ccc(cc3c2=O)-c2cn[nH]c2)c1 InChI=1S/C21H20N4O3/c1-27-17-4-6-20(28-2)15(9-17)7-8-25-13-22-19-5-3-14(10-18(19)21(25)26)16-11-23-24-12-16/h3-6,9-13H,7-8H2,1-2H3,(H,23,24) SFBQPOFFSZXYHF-UHFFFAOYSA-N 50533039 CHEMBL4579969 P2X purinoceptor 3 Homo sapiens 660 ChEMBL 10.1016/j.bmcl.2016.07.013 10.7270/Q2348PWW 27426300 Szántó, G; Makó, A; Vágó, I; Hergert, T; Bata, I; Farkas, B; Kolok, S; Vastag, M Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533039 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533039&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155565293 440741621 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315893 COc1cc(CCn2cnc3ccc(cc3c2=O)S(=O)(=O)N2CCCC2)cc(OC)c1 InChI=1S/C22H25N3O5S/c1-29-17-11-16(12-18(13-17)30-2)7-10-24-15-23-21-6-5-19(14-20(21)22(24)26)31(27,28)25-8-3-4-9-25/h5-6,11-15H,3-4,7-10H2,1-2H3 CMYPBEGQXFPIIC-UHFFFAOYSA-N 50533040 CHEMBL4456405 P2X purinoceptor 3 Homo sapiens 900 ChEMBL 10.1016/j.bmcl.2016.07.013 10.7270/Q2348PWW 27426300 Szántó, G; Makó, A; Vágó, I; Hergert, T; Bata, I; Farkas, B; Kolok, S; Vastag, M Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533040 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533040&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155525058 440741622 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315894 COc1ccc(OC)c(CCN2CCc3ccc(cc3C2=O)-c2ccccc2S(N)(=O)=O)c1 InChI=1S/C25H26N2O5S/c1-31-20-9-10-23(32-2)19(15-20)12-14-27-13-11-17-7-8-18(16-22(17)25(27)28)21-5-3-4-6-24(21)33(26,29)30/h3-10,15-16H,11-14H2,1-2H3,(H2,26,29,30) RAYXVMJDBIKHLY-UHFFFAOYSA-N 50533041 CHEMBL4468475 P2X purinoceptor 3 Homo sapiens 19 ChEMBL 10.1016/j.bmcl.2016.07.013 10.7270/Q2348PWW 27426300 Szántó, G; Makó, A; Vágó, I; Hergert, T; Bata, I; Farkas, B; Kolok, S; Vastag, M Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533041 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533041&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155533139 440741623 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315895 COc1ccc(OC)c(CCn2ccc3ccc(cc3c2=O)-c2ccccc2S(N)(=O)=O)c1 InChI=1S/C25H24N2O5S/c1-31-20-9-10-23(32-2)19(15-20)12-14-27-13-11-17-7-8-18(16-22(17)25(27)28)21-5-3-4-6-24(21)33(26,29)30/h3-11,13,15-16H,12,14H2,1-2H3,(H2,26,29,30) MOBLOIPYYFUXDD-UHFFFAOYSA-N 50533042 CHEMBL4471517 P2X purinoceptor 3 Homo sapiens 65 ChEMBL 10.1016/j.bmcl.2016.07.013 10.7270/Q2348PWW 27426300 Szántó, G; Makó, A; Vágó, I; Hergert, T; Bata, I; Farkas, B; Kolok, S; Vastag, M Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533042 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533042&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155535352 440741624 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315896 COc1cc(CCn2cnc3ccc(cc3c2=O)-c2c(C)noc2C)cc(OC)c1 InChI=1S/C23H23N3O4/c1-14-22(15(2)30-25-14)17-5-6-21-20(11-17)23(27)26(13-24-21)8-7-16-9-18(28-3)12-19(10-16)29-4/h5-6,9-13H,7-8H2,1-4H3 QSZLXPUMGIIDPD-UHFFFAOYSA-N 50533043 CHEMBL4437458 P2X purinoceptor 3 Homo sapiens 60 ChEMBL 10.1016/j.bmcl.2016.07.013 10.7270/Q2348PWW 27426300 Szántó, G; Makó, A; Vágó, I; Hergert, T; Bata, I; Farkas, B; Kolok, S; Vastag, M Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533043 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533043&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155512768 440741625 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315897 COc1cc(CCn2cnc3ccc(cc3c2=O)-c2cnc(OC)nc2OC)cc(OC)c1 InChI=1S/C24H24N4O5/c1-30-17-9-15(10-18(12-17)31-2)7-8-28-14-26-21-6-5-16(11-19(21)23(28)29)20-13-25-24(33-4)27-22(20)32-3/h5-6,9-14H,7-8H2,1-4H3 CUNQTBXYMBSXIM-UHFFFAOYSA-N 50533044 CHEMBL4440936 P2X purinoceptor 3 Homo sapiens 140 ChEMBL 10.1016/j.bmcl.2016.07.013 10.7270/Q2348PWW 27426300 Szántó, G; Makó, A; Vágó, I; Hergert, T; Bata, I; Farkas, B; Kolok, S; Vastag, M Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533044 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533044&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155514691 440741626 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315898 COc1cc(CCn2cnc3ccc(cc3c2=O)-c2cncnc2)cc(OC)c1 InChI=1S/C22H20N4O3/c1-28-18-7-15(8-19(10-18)29-2)5-6-26-14-25-21-4-3-16(9-20(21)22(26)27)17-11-23-13-24-12-17/h3-4,7-14H,5-6H2,1-2H3 HBKGCKMWRJAMMF-UHFFFAOYSA-N 50533045 CHEMBL4444083 P2X purinoceptor 3 Homo sapiens 3000 ChEMBL 10.1016/j.bmcl.2016.07.013 10.7270/Q2348PWW 27426300 Szántó, G; Makó, A; Vágó, I; Hergert, T; Bata, I; Farkas, B; Kolok, S; Vastag, M Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533045 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533045&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155517065 440741627 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315899 COc1cc(CCn2cnc3ccc(cc3c2=O)-c2ccccc2S(=O)(=O)N(C)C)cc(OC)c1 InChI=1S/C26H27N3O5S/c1-28(2)35(31,32)25-8-6-5-7-22(25)19-9-10-24-23(15-19)26(30)29(17-27-24)12-11-18-13-20(33-3)16-21(14-18)34-4/h5-10,13-17H,11-12H2,1-4H3 UNOKTSPSRMFMKO-UHFFFAOYSA-N 50533046 CHEMBL4475432 P2X purinoceptor 3 Homo sapiens 95 ChEMBL 10.1016/j.bmcl.2016.07.013 10.7270/Q2348PWW 27426300 Szántó, G; Makó, A; Vágó, I; Hergert, T; Bata, I; Farkas, B; Kolok, S; Vastag, M Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533046 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533046&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155537975 440741628 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315900 COc1cc(CCn2cnc3sc(CN4CCC(F)(F)C4)c(C)c3c2=O)cc(OC)c1 InChI=1S/C22H25F2N3O3S/c1-14-18(11-26-7-5-22(23,24)12-26)31-20-19(14)21(28)27(13-25-20)6-4-15-8-16(29-2)10-17(9-15)30-3/h8-10,13H,4-7,11-12H2,1-3H3 FENILTNNVRDUHN-UHFFFAOYSA-N 50533047 CHEMBL4440970 P2X purinoceptor 3 Homo sapiens 8700 ChEMBL 10.1016/j.bmcl.2016.07.013 10.7270/Q2348PWW 27426300 Szántó, G; Makó, A; Vágó, I; Hergert, T; Bata, I; Farkas, B; Kolok, S; Vastag, M Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533047 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533047&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155514887 440741629 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315901 COc1ncc(cn1)[C@@H](C)Nc1ncnc2CCN(Cc12)c1ccc(C)cc1C#N InChI=1S/C22H23N7O/c1-14-4-5-20(16(8-14)9-23)29-7-6-19-18(12-29)21(27-13-26-19)28-15(2)17-10-24-22(30-3)25-11-17/h4-5,8,10-11,13,15H,6-7,12H2,1-3H3,(H,26,27,28)/t15-/m1/s1 OSQOURHXWJQPNS-OAHLLOKOSA-N 50533048 CHEMBL3732768 P2X purinoceptor 3 Homo sapiens 10.0 ChEMBL 10.1016/j.bmcl.2016.07.013 10.7270/Q2348PWW 27426300 Szántó, G; Makó, A; Vágó, I; Hergert, T; Bata, I; Farkas, B; Kolok, S; Vastag, M Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533048 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533048&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 25060060 440741630 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315902 COc1ccc(OC)c(CCn2c(=O)n(C)c3ccc(cc3c2=O)-c2ccccc2S(N)(=O)=O)c1 InChI=1S/C25H25N3O6S/c1-27-21-10-8-16(19-6-4-5-7-23(19)35(26,31)32)15-20(21)24(29)28(25(27)30)13-12-17-14-18(33-2)9-11-22(17)34-3/h4-11,14-15H,12-13H2,1-3H3,(H2,26,31,32) SLDGUSKESKVMEL-UHFFFAOYSA-N 50533049 CHEMBL4593168 P2X purinoceptor 3 Homo sapiens 750 ChEMBL 10.1016/j.bmcl.2016.07.013 10.7270/Q2348PWW 27426300 Szántó, G; Makó, A; Vágó, I; Hergert, T; Bata, I; Farkas, B; Kolok, S; Vastag, M Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533049 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533049&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155568988 440741631 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315903 COc1cc(CCn2cnc3ccc(cc3c2=O)-c2cnc(OC)nc2)cc(OC)c1 InChI=1S/C23H22N4O4/c1-29-18-8-15(9-19(11-18)30-2)6-7-27-14-26-21-5-4-16(10-20(21)22(27)28)17-12-24-23(31-3)25-13-17/h4-5,8-14H,6-7H2,1-3H3 CJIXRYGDZCZSBF-UHFFFAOYSA-N 50533050 CHEMBL4483534 P2X purinoceptor 3 Homo sapiens 700 ChEMBL 10.1016/j.bmcl.2016.07.013 10.7270/Q2348PWW 27426300 Szántó, G; Makó, A; Vágó, I; Hergert, T; Bata, I; Farkas, B; Kolok, S; Vastag, M Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533050 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533050&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155540772 440741632 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315904 COc1ccc(OC)c(CCn2cnc3ccc(cc3c2=O)-c2cccc(c2)C(N)=O)c1 InChI=1S/C25H23N3O4/c1-31-20-7-9-23(32-2)18(13-20)10-11-28-15-27-22-8-6-17(14-21(22)25(28)30)16-4-3-5-19(12-16)24(26)29/h3-9,12-15H,10-11H2,1-2H3,(H2,26,29) DZEVZXZRKBIXAR-UHFFFAOYSA-N 50533051 CHEMBL4457753 P2X purinoceptor 3 Homo sapiens 45 ChEMBL 10.1016/j.bmcl.2016.07.013 10.7270/Q2348PWW 27426300 Szántó, G; Makó, A; Vágó, I; Hergert, T; Bata, I; Farkas, B; Kolok, S; Vastag, M Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533051 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533051&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155525867 440741633 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315905 COc1ccc(OC)c(CCn2c(=O)n(C)c3ccc(cc3c2=O)-c2ccccc2S(N)(=O)=O)c1 InChI=1S/C25H25N3O6S/c1-27-21-10-8-16(19-6-4-5-7-23(19)35(26,31)32)15-20(21)24(29)28(25(27)30)13-12-17-14-18(33-2)9-11-22(17)34-3/h4-11,14-15H,12-13H2,1-3H3,(H2,26,31,32) SLDGUSKESKVMEL-UHFFFAOYSA-N 50533049 CHEMBL4593168 P2X purinoceptor 3 Homo sapiens 750 ChEMBL 10.1016/j.bmcl.2016.07.013 10.7270/Q2348PWW 27426300 Szántó, G; Makó, A; Vágó, I; Hergert, T; Bata, I; Farkas, B; Kolok, S; Vastag, M Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533049 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533049&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155568988 440741631 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315906 COc1ccc(OC)c(CCn2cnc3ccc(cc3c2=O)-c2ccc(N)nc2C)c1 InChI=1S/C24H24N4O3/c1-15-19(6-9-23(25)27-15)16-4-7-21-20(13-16)24(29)28(14-26-21)11-10-17-12-18(30-2)5-8-22(17)31-3/h4-9,12-14H,10-11H2,1-3H3,(H2,25,27) LQRBEFQGUWALRR-UHFFFAOYSA-N 50533035 CHEMBL4521422 P2X purinoceptor 3 Homo sapiens 7.0 ChEMBL 10.1016/j.bmcl.2016.07.013 10.7270/Q2348PWW 27426300 Szántó, G; Makó, A; Vágó, I; Hergert, T; Bata, I; Farkas, B; Kolok, S; Vastag, M Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533035 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533035&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155542766 440741617 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315907 COc1ccc(OC)c(CCn2cnc3ccc(cc3c2=O)-c2ccc(NC(C)=O)cc2OC)c1 InChI=1S/C27H27N3O5/c1-17(31)29-20-6-8-22(26(15-20)35-4)18-5-9-24-23(14-18)27(32)30(16-28-24)12-11-19-13-21(33-2)7-10-25(19)34-3/h5-10,13-16H,11-12H2,1-4H3,(H,29,31) QIUZDABWOLZPEX-UHFFFAOYSA-N 50533036 CHEMBL4456466 P2X purinoceptor 3 Homo sapiens 5.0 ChEMBL 10.1016/j.bmcl.2016.07.013 10.7270/Q2348PWW 27426300 Szántó, G; Makó, A; Vágó, I; Hergert, T; Bata, I; Farkas, B; Kolok, S; Vastag, M Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533036 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533036&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155524530 440741618 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315908 COc1ccc(OC)c(CCn2cnc3ccc(cc3c2=O)-c2ccc(N)cc2OC)c1 InChI=1S/C25H25N3O4/c1-30-19-6-9-23(31-2)17(12-19)10-11-28-15-27-22-8-4-16(13-21(22)25(28)29)20-7-5-18(26)14-24(20)32-3/h4-9,12-15H,10-11,26H2,1-3H3 QBDAAIVUYJFOMZ-UHFFFAOYSA-N 50533037 CHEMBL4474615 P2X purinoceptor 3 Homo sapiens 20 ChEMBL 10.1016/j.bmcl.2016.07.013 10.7270/Q2348PWW 27426300 Szántó, G; Makó, A; Vágó, I; Hergert, T; Bata, I; Farkas, B; Kolok, S; Vastag, M Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533037 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533037&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155537072 440741619 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315909 COc1ccc(OC)c(CCn2cnc3ccc(cc3c2=O)-c2ccccc2OC)c1 InChI=1S/C25H24N2O4/c1-29-19-9-11-23(30-2)18(14-19)12-13-27-16-26-22-10-8-17(15-21(22)25(27)28)20-6-4-5-7-24(20)31-3/h4-11,14-16H,12-13H2,1-3H3 LDZAVHOMQUQGBB-UHFFFAOYSA-N 50533038 CHEMBL4577427 P2X purinoceptor 3 Homo sapiens 45 ChEMBL 10.1016/j.bmcl.2016.07.013 10.7270/Q2348PWW 27426300 Szántó, G; Makó, A; Vágó, I; Hergert, T; Bata, I; Farkas, B; Kolok, S; Vastag, M Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533038 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533038&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155564839 440741620 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315910 COc1ccc(OC)c(CCn2cnc3ccc(cc3c2=O)-c2cn[nH]c2)c1 InChI=1S/C21H20N4O3/c1-27-17-4-6-20(28-2)15(9-17)7-8-25-13-22-19-5-3-14(10-18(19)21(25)26)16-11-23-24-12-16/h3-6,9-13H,7-8H2,1-2H3,(H,23,24) SFBQPOFFSZXYHF-UHFFFAOYSA-N 50533039 CHEMBL4579969 P2X purinoceptor 3 Homo sapiens 660 ChEMBL 10.1016/j.bmcl.2016.07.013 10.7270/Q2348PWW 27426300 Szántó, G; Makó, A; Vágó, I; Hergert, T; Bata, I; Farkas, B; Kolok, S; Vastag, M Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533039 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533039&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155565293 440741621 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315911 COc1cc(CCn2cnc3ccc(cc3c2=O)S(=O)(=O)N2CCCC2)cc(OC)c1 InChI=1S/C22H25N3O5S/c1-29-17-11-16(12-18(13-17)30-2)7-10-24-15-23-21-6-5-19(14-20(21)22(24)26)31(27,28)25-8-3-4-9-25/h5-6,11-15H,3-4,7-10H2,1-2H3 CMYPBEGQXFPIIC-UHFFFAOYSA-N 50533040 CHEMBL4456405 P2X purinoceptor 3 Homo sapiens 900 ChEMBL 10.1016/j.bmcl.2016.07.013 10.7270/Q2348PWW 27426300 Szántó, G; Makó, A; Vágó, I; Hergert, T; Bata, I; Farkas, B; Kolok, S; Vastag, M Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533040 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533040&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155525058 440741622 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315912 COc1ccc(OC)c(CCN2CCc3ccc(cc3C2=O)-c2ccccc2S(N)(=O)=O)c1 InChI=1S/C25H26N2O5S/c1-31-20-9-10-23(32-2)19(15-20)12-14-27-13-11-17-7-8-18(16-22(17)25(27)28)21-5-3-4-6-24(21)33(26,29)30/h3-10,15-16H,11-14H2,1-2H3,(H2,26,29,30) RAYXVMJDBIKHLY-UHFFFAOYSA-N 50533041 CHEMBL4468475 P2X purinoceptor 3 Homo sapiens 19 ChEMBL 10.1016/j.bmcl.2016.07.013 10.7270/Q2348PWW 27426300 Szántó, G; Makó, A; Vágó, I; Hergert, T; Bata, I; Farkas, B; Kolok, S; Vastag, M Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533041 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533041&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155533139 440741623 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315913 COc1ccc(OC)c(CCn2ccc3ccc(cc3c2=O)-c2ccccc2S(N)(=O)=O)c1 InChI=1S/C25H24N2O5S/c1-31-20-9-10-23(32-2)19(15-20)12-14-27-13-11-17-7-8-18(16-22(17)25(27)28)21-5-3-4-6-24(21)33(26,29)30/h3-11,13,15-16H,12,14H2,1-2H3,(H2,26,29,30) MOBLOIPYYFUXDD-UHFFFAOYSA-N 50533042 CHEMBL4471517 P2X purinoceptor 3 Homo sapiens 65 ChEMBL 10.1016/j.bmcl.2016.07.013 10.7270/Q2348PWW 27426300 Szántó, G; Makó, A; Vágó, I; Hergert, T; Bata, I; Farkas, B; Kolok, S; Vastag, M Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533042 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533042&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155535352 440741624 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315914 COc1cc(CCn2cnc3ccc(cc3c2=O)-c2c(C)noc2C)cc(OC)c1 InChI=1S/C23H23N3O4/c1-14-22(15(2)30-25-14)17-5-6-21-20(11-17)23(27)26(13-24-21)8-7-16-9-18(28-3)12-19(10-16)29-4/h5-6,9-13H,7-8H2,1-4H3 QSZLXPUMGIIDPD-UHFFFAOYSA-N 50533043 CHEMBL4437458 P2X purinoceptor 3 Homo sapiens 60 ChEMBL 10.1016/j.bmcl.2016.07.013 10.7270/Q2348PWW 27426300 Szántó, G; Makó, A; Vágó, I; Hergert, T; Bata, I; Farkas, B; Kolok, S; Vastag, M Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533043 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533043&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155512768 440741625 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315915 COc1cc(CCn2cnc3ccc(cc3c2=O)-c2cnc(OC)nc2OC)cc(OC)c1 InChI=1S/C24H24N4O5/c1-30-17-9-15(10-18(12-17)31-2)7-8-28-14-26-21-6-5-16(11-19(21)23(28)29)20-13-25-24(33-4)27-22(20)32-3/h5-6,9-14H,7-8H2,1-4H3 CUNQTBXYMBSXIM-UHFFFAOYSA-N 50533044 CHEMBL4440936 P2X purinoceptor 3 Homo sapiens 140 ChEMBL 10.1016/j.bmcl.2016.07.013 10.7270/Q2348PWW 27426300 Szántó, G; Makó, A; Vágó, I; Hergert, T; Bata, I; Farkas, B; Kolok, S; Vastag, M Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533044 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533044&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155514691 440741626 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315916 COc1cc(CCn2cnc3ccc(cc3c2=O)-c2cncnc2)cc(OC)c1 InChI=1S/C22H20N4O3/c1-28-18-7-15(8-19(10-18)29-2)5-6-26-14-25-21-4-3-16(9-20(21)22(26)27)17-11-23-13-24-12-17/h3-4,7-14H,5-6H2,1-2H3 HBKGCKMWRJAMMF-UHFFFAOYSA-N 50533045 CHEMBL4444083 P2X purinoceptor 3 Homo sapiens 3000 ChEMBL 10.1016/j.bmcl.2016.07.013 10.7270/Q2348PWW 27426300 Szántó, G; Makó, A; Vágó, I; Hergert, T; Bata, I; Farkas, B; Kolok, S; Vastag, M Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533045 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533045&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155517065 440741627 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315917 COc1cc(CCn2cnc3ccc(cc3c2=O)-c2ccccc2S(=O)(=O)N(C)C)cc(OC)c1 InChI=1S/C26H27N3O5S/c1-28(2)35(31,32)25-8-6-5-7-22(25)19-9-10-24-23(15-19)26(30)29(17-27-24)12-11-18-13-20(33-3)16-21(14-18)34-4/h5-10,13-17H,11-12H2,1-4H3 UNOKTSPSRMFMKO-UHFFFAOYSA-N 50533046 CHEMBL4475432 P2X purinoceptor 3 Homo sapiens 95 ChEMBL 10.1016/j.bmcl.2016.07.013 10.7270/Q2348PWW 27426300 Szántó, G; Makó, A; Vágó, I; Hergert, T; Bata, I; Farkas, B; Kolok, S; Vastag, M Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533046 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533046&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155537975 440741628 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315918 COc1cc(CCn2cnc3sc(CN4CCC(F)(F)C4)c(C)c3c2=O)cc(OC)c1 InChI=1S/C22H25F2N3O3S/c1-14-18(11-26-7-5-22(23,24)12-26)31-20-19(14)21(28)27(13-25-20)6-4-15-8-16(29-2)10-17(9-15)30-3/h8-10,13H,4-7,11-12H2,1-3H3 FENILTNNVRDUHN-UHFFFAOYSA-N 50533047 CHEMBL4440970 P2X purinoceptor 3 Homo sapiens 8700 ChEMBL 10.1016/j.bmcl.2016.07.013 10.7270/Q2348PWW 27426300 Szántó, G; Makó, A; Vágó, I; Hergert, T; Bata, I; Farkas, B; Kolok, S; Vastag, M Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533047 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533047&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155514887 440741629 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315919 COc1ncc(cn1)[C@@H](C)Nc1ncnc2CCN(Cc12)c1ccc(C)cc1C#N InChI=1S/C22H23N7O/c1-14-4-5-20(16(8-14)9-23)29-7-6-19-18(12-29)21(27-13-26-19)28-15(2)17-10-24-22(30-3)25-11-17/h4-5,8,10-11,13,15H,6-7,12H2,1-3H3,(H,26,27,28)/t15-/m1/s1 OSQOURHXWJQPNS-OAHLLOKOSA-N 50533048 CHEMBL3732768 P2X purinoceptor 3 Homo sapiens 10.0 ChEMBL 10.1016/j.bmcl.2016.07.013 10.7270/Q2348PWW 27426300 Szántó, G; Makó, A; Vágó, I; Hergert, T; Bata, I; Farkas, B; Kolok, S; Vastag, M Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533048 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533048&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 25060060 440741630 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315920 COc1ccc(OC)c(CCn2cnc3ccc(cc3c2=O)-c2ccc(NC(C)=O)nc2C)c1 InChI=1S/C26H26N4O4/c1-16-21(7-10-25(28-16)29-17(2)31)18-5-8-23-22(14-18)26(32)30(15-27-23)12-11-19-13-20(33-3)6-9-24(19)34-4/h5-10,13-15H,11-12H2,1-4H3,(H,28,29,31) FPXDQZUOFXALPE-UHFFFAOYSA-N 50533052 CHEMBL4464155 P2X purinoceptor 3 Homo sapiens 6.0 ChEMBL 10.1016/j.bmcl.2016.07.013 10.7270/Q2348PWW 27426300 Szántó, G; Makó, A; Vágó, I; Hergert, T; Bata, I; Farkas, B; Kolok, S; Vastag, M Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533052 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533052&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155530055 440741634 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315921 COc1ccc(OC)c(CCn2cnc3ccc(cc3c2=O)-c2cc(OC)ccc2OC)c1 InChI=1S/C26H26N2O5/c1-30-19-6-9-24(32-3)18(13-19)11-12-28-16-27-23-8-5-17(14-22(23)26(28)29)21-15-20(31-2)7-10-25(21)33-4/h5-10,13-16H,11-12H2,1-4H3 SUQFNLZTIGURLW-UHFFFAOYSA-N 50533053 CHEMBL4514350 P2X purinoceptor 3 Homo sapiens 65 ChEMBL 10.1016/j.bmcl.2016.07.013 10.7270/Q2348PWW 27426300 Szántó, G; Makó, A; Vágó, I; Hergert, T; Bata, I; Farkas, B; Kolok, S; Vastag, M Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533053 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533053&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155539221 440741635 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315922 COc1cc(CCn2cnc3ccc(cc3c2=O)S(=O)(=O)N(C)C)cc(OC)c1 InChI=1S/C20H23N3O5S/c1-22(2)29(25,26)17-5-6-19-18(12-17)20(24)23(13-21-19)8-7-14-9-15(27-3)11-16(10-14)28-4/h5-6,9-13H,7-8H2,1-4H3 HBISQTBGMOSBIA-UHFFFAOYSA-N 50533054 CHEMBL4474878 P2X purinoceptor 3 Homo sapiens 1500 ChEMBL 10.1016/j.bmcl.2016.07.013 10.7270/Q2348PWW 27426300 Szántó, G; Makó, A; Vágó, I; Hergert, T; Bata, I; Farkas, B; Kolok, S; Vastag, M Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533054 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533054&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155537553 440741636 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315923 COc1ccc(OC)c(c1)C(C)n1cnc2ccc(cc2c1=O)-c1ccccc1S(N)(=O)=O InChI=1S/C24H23N3O5S/c1-15(19-13-17(31-2)9-11-22(19)32-3)27-14-26-21-10-8-16(12-20(21)24(27)28)18-6-4-5-7-23(18)33(25,29)30/h4-15H,1-3H3,(H2,25,29,30) PHUPQQXOHADNPR-UHFFFAOYSA-N 50533055 CHEMBL4516703 P2X purinoceptor 3 Homo sapiens 400 ChEMBL 10.1016/j.bmcl.2016.07.013 10.7270/Q2348PWW 27426300 Szántó, G; Makó, A; Vágó, I; Hergert, T; Bata, I; Farkas, B; Kolok, S; Vastag, M Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533055 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533055&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155540414 440741637 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315924 COc1cc(CCn2cnc3ccc(cc3c2=O)-c2ccccc2S(N)(=O)=O)cc(OC)c1 InChI=1S/C24H23N3O5S/c1-31-18-11-16(12-19(14-18)32-2)9-10-27-15-26-22-8-7-17(13-21(22)24(27)28)20-5-3-4-6-23(20)33(25,29)30/h3-8,11-15H,9-10H2,1-2H3,(H2,25,29,30) PDTSNLALWOPJJY-UHFFFAOYSA-N 50533056 CHEMBL4435576 P2X purinoceptor 3 Homo sapiens 130 ChEMBL 10.1016/j.bmcl.2016.07.013 10.7270/Q2348PWW 27426300 Szántó, G; Makó, A; Vágó, I; Hergert, T; Bata, I; Farkas, B; Kolok, S; Vastag, M Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533056 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533056&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155511397 440741638 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315925 COc1cc(CCn2cncc(-c3ccc(cc3)S(=O)(=O)N(C)C)c2=O)cc(OC)c1 InChI=1S/C22H25N3O5S/c1-24(2)31(27,28)20-7-5-17(6-8-20)21-14-23-15-25(22(21)26)10-9-16-11-18(29-3)13-19(12-16)30-4/h5-8,11-15H,9-10H2,1-4H3 ASHKJLPQEGTJOZ-UHFFFAOYSA-N 50533057 CHEMBL4530323 P2X purinoceptor 3 Homo sapiens 10000 ChEMBL 10.1016/j.bmcl.2016.07.013 10.7270/Q2348PWW 27426300 Szántó, G; Makó, A; Vágó, I; Hergert, T; Bata, I; Farkas, B; Kolok, S; Vastag, M Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533057 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533057&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155545879 440741639 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315926 COc1cc(CCn2cnc3ccc(cc3c2=O)S(=O)(=O)N2CCCCC2)cc(OC)c1 InChI=1S/C23H27N3O5S/c1-30-18-12-17(13-19(14-18)31-2)8-11-25-16-24-22-7-6-20(15-21(22)23(25)27)32(28,29)26-9-4-3-5-10-26/h6-7,12-16H,3-5,8-11H2,1-2H3 FKHCMHKLPKGKCR-UHFFFAOYSA-N 50533058 CHEMBL4561258 P2X purinoceptor 3 Homo sapiens 170 ChEMBL 10.1016/j.bmcl.2016.07.013 10.7270/Q2348PWW 27426300 Szántó, G; Makó, A; Vágó, I; Hergert, T; Bata, I; Farkas, B; Kolok, S; Vastag, M Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533058 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533058&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155543378 440741640 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315927 COc1cc(CCn2cnc3ccc(cc3c2=O)S(=O)(=O)N2CCCCC2)cc(OC)c1 InChI=1S/C23H27N3O5S/c1-30-18-12-17(13-19(14-18)31-2)8-11-25-16-24-22-7-6-20(15-21(22)23(25)27)32(28,29)26-9-4-3-5-10-26/h6-7,12-16H,3-5,8-11H2,1-2H3 FKHCMHKLPKGKCR-UHFFFAOYSA-N 50533058 CHEMBL4561258 P2X purinoceptor 3 Homo sapiens 170 ChEMBL 10.1016/j.bmcl.2016.07.013 10.7270/Q2348PWW 27426300 Szántó, G; Makó, A; Vágó, I; Hergert, T; Bata, I; Farkas, B; Kolok, S; Vastag, M Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533058 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533058&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155543378 440741640 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315928 COc1ccc(OC)c(CCn2cnc3ccc(cc3c2=O)-c2ccc(NC(C)=O)nc2C)c1 InChI=1S/C26H26N4O4/c1-16-21(7-10-25(28-16)29-17(2)31)18-5-8-23-22(14-18)26(32)30(15-27-23)12-11-19-13-20(33-3)6-9-24(19)34-4/h5-10,13-15H,11-12H2,1-4H3,(H,28,29,31) FPXDQZUOFXALPE-UHFFFAOYSA-N 50533052 CHEMBL4464155 P2X purinoceptor 3 Homo sapiens 6.0 ChEMBL 10.1016/j.bmcl.2016.07.013 10.7270/Q2348PWW 27426300 Szántó, G; Makó, A; Vágó, I; Hergert, T; Bata, I; Farkas, B; Kolok, S; Vastag, M Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533052 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533052&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155530055 440741634 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315929 COc1ccc(OC)c(CCn2cnc3ccc(cc3c2=O)-c2cc(OC)ccc2OC)c1 InChI=1S/C26H26N2O5/c1-30-19-6-9-24(32-3)18(13-19)11-12-28-16-27-23-8-5-17(14-22(23)26(28)29)21-15-20(31-2)7-10-25(21)33-4/h5-10,13-16H,11-12H2,1-4H3 SUQFNLZTIGURLW-UHFFFAOYSA-N 50533053 CHEMBL4514350 P2X purinoceptor 3 Homo sapiens 65 ChEMBL 10.1016/j.bmcl.2016.07.013 10.7270/Q2348PWW 27426300 Szántó, G; Makó, A; Vágó, I; Hergert, T; Bata, I; Farkas, B; Kolok, S; Vastag, M Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533053 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533053&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155539221 440741635 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315930 COc1cc(CCn2cnc3ccc(cc3c2=O)S(=O)(=O)N(C)C)cc(OC)c1 InChI=1S/C20H23N3O5S/c1-22(2)29(25,26)17-5-6-19-18(12-17)20(24)23(13-21-19)8-7-14-9-15(27-3)11-16(10-14)28-4/h5-6,9-13H,7-8H2,1-4H3 HBISQTBGMOSBIA-UHFFFAOYSA-N 50533054 CHEMBL4474878 P2X purinoceptor 3 Homo sapiens 1500 ChEMBL 10.1016/j.bmcl.2016.07.013 10.7270/Q2348PWW 27426300 Szántó, G; Makó, A; Vágó, I; Hergert, T; Bata, I; Farkas, B; Kolok, S; Vastag, M Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533054 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533054&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155537553 440741636 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315931 COc1ccc(OC)c(c1)C(C)n1cnc2ccc(cc2c1=O)-c1ccccc1S(N)(=O)=O InChI=1S/C24H23N3O5S/c1-15(19-13-17(31-2)9-11-22(19)32-3)27-14-26-21-10-8-16(12-20(21)24(27)28)18-6-4-5-7-23(18)33(25,29)30/h4-15H,1-3H3,(H2,25,29,30) PHUPQQXOHADNPR-UHFFFAOYSA-N 50533055 CHEMBL4516703 P2X purinoceptor 3 Homo sapiens 400 ChEMBL 10.1016/j.bmcl.2016.07.013 10.7270/Q2348PWW 27426300 Szántó, G; Makó, A; Vágó, I; Hergert, T; Bata, I; Farkas, B; Kolok, S; Vastag, M Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533055 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533055&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155540414 440741637 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315932 COc1cc(CCn2cnc3ccc(cc3c2=O)-c2ccccc2S(N)(=O)=O)cc(OC)c1 InChI=1S/C24H23N3O5S/c1-31-18-11-16(12-19(14-18)32-2)9-10-27-15-26-22-8-7-17(13-21(22)24(27)28)20-5-3-4-6-23(20)33(25,29)30/h3-8,11-15H,9-10H2,1-2H3,(H2,25,29,30) PDTSNLALWOPJJY-UHFFFAOYSA-N 50533056 CHEMBL4435576 P2X purinoceptor 3 Homo sapiens 130 ChEMBL 10.1016/j.bmcl.2016.07.013 10.7270/Q2348PWW 27426300 Szántó, G; Makó, A; Vágó, I; Hergert, T; Bata, I; Farkas, B; Kolok, S; Vastag, M Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533056 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533056&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155511397 440741638 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315933 COc1cc(CCn2cncc(-c3ccc(cc3)S(=O)(=O)N(C)C)c2=O)cc(OC)c1 InChI=1S/C22H25N3O5S/c1-24(2)31(27,28)20-7-5-17(6-8-20)21-14-23-15-25(22(21)26)10-9-16-11-18(29-3)13-19(12-16)30-4/h5-8,11-15H,9-10H2,1-4H3 ASHKJLPQEGTJOZ-UHFFFAOYSA-N 50533057 CHEMBL4530323 P2X purinoceptor 3 Homo sapiens 10000 ChEMBL 10.1016/j.bmcl.2016.07.013 10.7270/Q2348PWW 27426300 Szántó, G; Makó, A; Vágó, I; Hergert, T; Bata, I; Farkas, B; Kolok, S; Vastag, M Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533057 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533057&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155545879 440741639 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315934 COc1cc(CCn2cnc3ccc(cc3c2=O)-c2cnc(OC)nc2)cc(OC)c1 InChI=1S/C23H22N4O4/c1-29-18-8-15(9-19(11-18)30-2)6-7-27-14-26-21-5-4-16(10-20(21)22(27)28)17-12-24-23(31-3)25-13-17/h4-5,8-14H,6-7H2,1-3H3 CJIXRYGDZCZSBF-UHFFFAOYSA-N 50533050 CHEMBL4483534 P2X purinoceptor 3 Homo sapiens 700 ChEMBL 10.1016/j.bmcl.2016.07.013 10.7270/Q2348PWW 27426300 Szántó, G; Makó, A; Vágó, I; Hergert, T; Bata, I; Farkas, B; Kolok, S; Vastag, M Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533050 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533050&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155540772 440741632 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51315935 COc1ccc(OC)c(CCn2cnc3ccc(cc3c2=O)-c2cccc(c2)C(N)=O)c1 InChI=1S/C25H23N3O4/c1-31-20-7-9-23(32-2)18(13-20)10-11-28-15-27-22-8-6-17(14-21(22)25(28)30)16-4-3-5-19(12-16)24(26)29/h3-9,12-15H,10-11H2,1-2H3,(H2,26,29) DZEVZXZRKBIXAR-UHFFFAOYSA-N 50533051 CHEMBL4457753 P2X purinoceptor 3 Homo sapiens 45 ChEMBL 10.1016/j.bmcl.2016.07.013 10.7270/Q2348PWW 27426300 Szántó, G; Makó, A; Vágó, I; Hergert, T; Bata, I; Farkas, B; Kolok, S; Vastag, M Gedeon Richter Plc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533051 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533051&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155525867 440741633 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51323239 N.N.N.N.Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@H]2OC3(CCCCC3)O[C@@H]12 InChI=1S/C16H24N5O13P3.4H3N/c17-13-10-14(19-7-18-13)21(8-20-10)15-12-11(31-16(32-12)4-2-1-3-5-16)9(30-15)6-29-36(25,26)34-37(27,28)33-35(22,23)24;;;;/h7-9,11-12,15H,1-6H2,(H,25,26)(H,27,28)(H2,17,18,19)(H2,22,23,24);4*1H3/t9-,11-,12-,15-;;;;/m1..../s1 MYODNHHKQWEUOO-GLBHFFKESA-N 50535410 CHEMBL4525343 P2X purinoceptor 3 Homo sapiens 883 ChEMBL 10.1021/acsmedchemlett.8b00524 10.7270/Q27W6GPS 30996785 Dal Ben, D; Buccioni, M; Lambertucci, C; Marucci, G; Spinaci, A; Marchenkova, A; Abdelrahman, A; Nistri, A; Müller, CE; Volpini, R University of Camerino http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50535410 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50535410&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155543044 440743992 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51323254 N.N.N.N.Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@H]2O[C@H](O[C@@H]12)c1ccccc1 InChI=1S/C17H20N5O13P3.4H3N/c18-14-11-15(20-7-19-14)22(8-21-11)16-13-12(32-17(33-13)9-4-2-1-3-5-9)10(31-16)6-30-37(26,27)35-38(28,29)34-36(23,24)25;;;;/h1-5,7-8,10,12-13,16-17H,6H2,(H,26,27)(H,28,29)(H2,18,19,20)(H2,23,24,25);4*1H3/t10-,12-,13-,16-,17-;;;;/m1..../s1 BCGDNNLMSKVHGV-ZQNBMKNCSA-N 50535414 CHEMBL4463334 P2X purinoceptor 3 Homo sapiens 611 ChEMBL 10.1021/acsmedchemlett.8b00524 10.7270/Q27W6GPS 30996785 Dal Ben, D; Buccioni, M; Lambertucci, C; Marucci, G; Spinaci, A; Marchenkova, A; Abdelrahman, A; Nistri, A; Müller, CE; Volpini, R University of Camerino http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50535414 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50535414&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155529713 440743996 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51323255 N.N.N.N.Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@H]2OCO[C@@H]12 InChI=1S/C11H16N5O13P3.4H3N/c12-9-6-10(14-2-13-9)16(3-15-6)11-8-7(24-4-25-8)5(27-11)1-26-31(20,21)29-32(22,23)28-30(17,18)19;;;;/h2-3,5,7-8,11H,1,4H2,(H,20,21)(H,22,23)(H2,12,13,14)(H2,17,18,19);4*1H3/t5-,7-,8-,11-;;;;/m1..../s1 JUSWNBNJCUGXNH-WHEJUCFXSA-N 50535413 CHEMBL4561510 P2X purinoceptor 3 Homo sapiens >100000 ChEMBL 10.1021/acsmedchemlett.8b00524 10.7270/Q27W6GPS 30996785 Dal Ben, D; Buccioni, M; Lambertucci, C; Marucci, G; Spinaci, A; Marchenkova, A; Abdelrahman, A; Nistri, A; Müller, CE; Volpini, R University of Camerino http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50535413 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50535413&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155559078 440743995 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51323256 N.N.N.N.CC1(C)O[C@@H]2[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]([C@@H]2O1)n1cnc2c(N)ncnc12 InChI=1S/C13H20N5O13P3.4H3N/c1-13(2)28-8-6(3-26-33(22,23)31-34(24,25)30-32(19,20)21)27-12(9(8)29-13)18-5-17-7-10(14)15-4-16-11(7)18;;;;/h4-6,8-9,12H,3H2,1-2H3,(H,22,23)(H,24,25)(H2,14,15,16)(H2,19,20,21);4*1H3/t6-,8-,9-,12-;;;;/m1..../s1 FGJFXUBAGAIUAL-HVYRMSERSA-N 50535408 CHEMBL4462568 P2X purinoceptor 3 Homo sapiens 4110 ChEMBL 10.1021/acsmedchemlett.8b00524 10.7270/Q27W6GPS 30996785 Dal Ben, D; Buccioni, M; Lambertucci, C; Marucci, G; Spinaci, A; Marchenkova, A; Abdelrahman, A; Nistri, A; Müller, CE; Volpini, R University of Camerino http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50535408 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50535408&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155529242 440743990 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51323257 CC1(C)O[C@H]2[C@@H](O1)[C@@H](O[C@@H]2C(=O)N[C@@H](CCC(O)=O)C(O)=O)n1cnc2c(N)ncnc12 InChI=1S/C18H22N6O8/c1-18(2)31-10-11(15(27)23-7(17(28)29)3-4-8(25)26)30-16(12(10)32-18)24-6-22-9-13(19)20-5-21-14(9)24/h5-7,10-12,16H,3-4H2,1-2H3,(H,23,27)(H,25,26)(H,28,29)(H2,19,20,21)/t7-,10+,11-,12+,16+/m0/s1 SZCHMKMPWUDZBK-JISRJMKVSA-N 50535411 CHEMBL4440260 P2X purinoceptor 3 Homo sapiens >100000 ChEMBL 10.1021/acsmedchemlett.8b00524 10.7270/Q27W6GPS 30996785 Dal Ben, D; Buccioni, M; Lambertucci, C; Marucci, G; Spinaci, A; Marchenkova, A; Abdelrahman, A; Nistri, A; Müller, CE; Volpini, R University of Camerino http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50535411 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50535411&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155514310 440743993 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51323267 N.N.N.N.Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@H]2O[C@@H](O[C@@H]12)c1ccccc1 InChI=1S/C17H20N5O13P3.4H3N/c18-14-11-15(20-7-19-14)22(8-21-11)16-13-12(32-17(33-13)9-4-2-1-3-5-9)10(31-16)6-30-37(26,27)35-38(28,29)34-36(23,24)25;;;;/h1-5,7-8,10,12-13,16-17H,6H2,(H,26,27)(H,28,29)(H2,18,19,20)(H2,23,24,25);4*1H3/t10-,12-,13-,16-,17+;;;;/m1..../s1 BCGDNNLMSKVHGV-TVTGSROBSA-N 50535409 CHEMBL4456926 P2X purinoceptor 3 Homo sapiens 5830 ChEMBL 10.1021/acsmedchemlett.8b00524 10.7270/Q27W6GPS 30996785 Dal Ben, D; Buccioni, M; Lambertucci, C; Marucci, G; Spinaci, A; Marchenkova, A; Abdelrahman, A; Nistri, A; Müller, CE; Volpini, R University of Camerino http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50535409 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50535409&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155526224 440743991 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51323268 N.N.N.N.Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)CP(O)(=O)OP(O)(O)=O)[C@H]2OC3(CCCCC3)O[C@@H]12 InChI=1S/C17H26N5O12P3.4H3N/c18-14-11-15(20-7-19-14)22(8-21-11)16-13-12(32-17(33-13)4-2-1-3-5-17)10(31-16)6-30-35(23,24)9-36(25,26)34-37(27,28)29;;;;/h7-8,10,12-13,16H,1-6,9H2,(H,23,24)(H,25,26)(H2,18,19,20)(H2,27,28,29);4*1H3/t10-,12-,13-,16-;;;;/m1..../s1 AKBRTCIGLUNYMV-ORWCUUFYSA-N 50535415 CHEMBL4463578 P2X purinoceptor 3 Homo sapiens 17500 ChEMBL 10.1021/acsmedchemlett.8b00524 10.7270/Q27W6GPS 30996785 Dal Ben, D; Buccioni, M; Lambertucci, C; Marucci, G; Spinaci, A; Marchenkova, A; Abdelrahman, A; Nistri, A; Müller, CE; Volpini, R University of Camerino http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50535415 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50535415&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155529971 440743997 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51335146 Oc1ccc(Cl)cc1C(=O)Nc1cc(cc(c1)C(F)(F)F)C(F)(F)F InChI=1S/C15H8ClF6NO2/c16-9-1-2-12(24)11(6-9)13(25)23-10-4-7(14(17,18)19)3-8(5-10)15(20,21)22/h1-6,24H,(H,23,25) CHILCFMQWMQVAL-UHFFFAOYSA-N 50430160 CHEMBL536151::TCMDC-125465 P2X purinoceptor 3 Homo sapiens >10000 ChEMBL 10.1021/acs.jmedchem.0c00435 10.7270/Q24F1V93 32345019 Tian, M; Abdelrahman, A; Baqi, Y; Fuentes, E; Azazna, D; Spanier, C; Densborn, S; Hinz, S; Schmid, R; Müller, CE University of Bonn http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50430160 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50430160&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 5081913 164159035 CHEMBL536151 ZINC03986227 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51335147 Oc1ccccc1C(=O)Nc1cc(cc(c1)C(F)(F)F)C(F)(F)F InChI=1S/C15H9F6NO2/c16-14(17,18)8-5-9(15(19,20)21)7-10(6-8)22-13(24)11-3-1-2-4-12(11)23/h1-7,23H,(H,22,24) LIPWVXLUWLNIBY-UHFFFAOYSA-N 50430159 CHEMBL461542 P2X purinoceptor 3 Homo sapiens >10000 ChEMBL 10.1021/acs.jmedchem.0c00435 10.7270/Q24F1V93 32345019 Tian, M; Abdelrahman, A; Baqi, Y; Fuentes, E; Azazna, D; Spanier, C; Densborn, S; Hinz, S; Schmid, R; Müller, CE University of Bonn http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50430159 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50430159&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 9975090 164159034 CHEMBL461542 ZINC40865489 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51335148 Oc1c(Cl)cccc1C(=O)Nc1cc(cc(c1)C(F)(F)F)C(F)(F)F InChI=1S/C15H8ClF6NO2/c16-11-3-1-2-10(12(11)24)13(25)23-9-5-7(14(17,18)19)4-8(6-9)15(20,21)22/h1-6,24H,(H,23,25) MIFXBNFNNPOWOG-UHFFFAOYSA-N 50430156 CHEMBL2338695 P2X purinoceptor 3 Homo sapiens >10000 ChEMBL 10.1021/acs.jmedchem.0c00435 10.7270/Q24F1V93 32345019 Tian, M; Abdelrahman, A; Baqi, Y; Fuentes, E; Azazna, D; Spanier, C; Densborn, S; Hinz, S; Schmid, R; Müller, CE University of Bonn http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50430156 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50430156&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 71381242 164159031 CHEMBL2338695 ZINC90624096 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51335149 Oc1cc(Cl)ccc1C(=O)Nc1cc(cc(c1)C(F)(F)F)C(F)(F)F InChI=1S/C15H8ClF6NO2/c16-9-1-2-11(12(24)6-9)13(25)23-10-4-7(14(17,18)19)3-8(5-10)15(20,21)22/h1-6,24H,(H,23,25) OWGDIPHHKWBGJY-UHFFFAOYSA-N 50430195 CHEMBL2338696 P2X purinoceptor 3 Homo sapiens >10000 ChEMBL 10.1021/acs.jmedchem.0c00435 10.7270/Q24F1V93 32345019 Tian, M; Abdelrahman, A; Baqi, Y; Fuentes, E; Azazna, D; Spanier, C; Densborn, S; Hinz, S; Schmid, R; Müller, CE University of Bonn http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50430195 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50430195&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 23070355 164159070 CHEMBL2338696 ZINC95591336 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51335150 Oc1c(F)cccc1C(=O)Nc1cc(cc(c1)C(F)(F)F)C(F)(F)F InChI=1S/C15H8F7NO2/c16-11-3-1-2-10(12(11)24)13(25)23-9-5-7(14(17,18)19)4-8(6-9)15(20,21)22/h1-6,24H,(H,23,25) OGACTSAOCINRLN-UHFFFAOYSA-N 50540422 CHEMBL4644398 P2X purinoceptor 3 Homo sapiens >10000 ChEMBL 10.1021/acs.jmedchem.0c00435 10.7270/Q24F1V93 32345019 Tian, M; Abdelrahman, A; Baqi, Y; Fuentes, E; Azazna, D; Spanier, C; Densborn, S; Hinz, S; Schmid, R; Müller, CE University of Bonn http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50540422 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50540422&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 151318798 442141985 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51335151 Oc1c(ccc2ccccc12)C(=O)Nc1cc(cc(c1)C(F)(F)F)C(F)(F)F InChI=1S/C19H11F6NO2/c20-18(21,22)11-7-12(19(23,24)25)9-13(8-11)26-17(28)15-6-5-10-3-1-2-4-14(10)16(15)27/h1-9,27H,(H,26,28) GTIRCXWYMTWWRW-UHFFFAOYSA-N 50430170 CHEMBL2338686 P2X purinoceptor 3 Homo sapiens 195 ChEMBL 10.1021/acs.jmedchem.0c00435 10.7270/Q24F1V93 32345019 Tian, M; Abdelrahman, A; Baqi, Y; Fuentes, E; Azazna, D; Spanier, C; Densborn, S; Hinz, S; Schmid, R; Müller, CE University of Bonn http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50430170 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50430170&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 11741624 164159045 CHEMBL2338686 ZINC36400849 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51335152 Oc1ccc(Cl)cc1C(=O)Nc1cccc(c1)C(F)(F)F InChI=1S/C14H9ClF3NO2/c15-9-4-5-12(20)11(7-9)13(21)19-10-3-1-2-8(6-10)14(16,17)18/h1-7,20H,(H,19,21) OAMVIBKEICGPKK-UHFFFAOYSA-N 50430176 CHEMBL589733::MMV665807::SJ000010289 P2X purinoceptor 3 Homo sapiens >10000 ChEMBL 10.1021/acs.jmedchem.0c00435 10.7270/Q24F1V93 32345019 Tian, M; Abdelrahman, A; Baqi, Y; Fuentes, E; Azazna, D; Spanier, C; Densborn, S; Hinz, S; Schmid, R; Müller, CE University of Bonn http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50430176 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50430176&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 5065884 164159051 CHEMBL589733 ZINC00263553 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51335153 Oc1ccc(Cl)cc1C(=O)Nc1ccc(cc1)C(F)(F)F InChI=1S/C14H9ClF3NO2/c15-9-3-6-12(20)11(7-9)13(21)19-10-4-1-8(2-5-10)14(16,17)18/h1-7,20H,(H,19,21) QCRAHGZZLAXPCG-UHFFFAOYSA-N 50430177 CHEMBL2088014 P2X purinoceptor 3 Homo sapiens >10000 ChEMBL 10.1021/acs.jmedchem.0c00435 10.7270/Q24F1V93 32345019 Tian, M; Abdelrahman, A; Baqi, Y; Fuentes, E; Azazna, D; Spanier, C; Densborn, S; Hinz, S; Schmid, R; Müller, CE University of Bonn http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50430177 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50430177&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 5274059 164159052 CHEMBL2088014 ZINC20550749 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51335154 Oc1ccc(Cl)cc1C(=O)Nc1cc(cc(c1)C(F)(F)F)[N+]([O-])=O InChI=1S/C14H8ClF3N2O4/c15-8-1-2-12(21)11(5-8)13(22)19-9-3-7(14(16,17)18)4-10(6-9)20(23)24/h1-6,21H,(H,19,22) DDYZDHRELNHRNM-UHFFFAOYSA-N 50540434 CHEMBL4640175 P2X purinoceptor 3 Homo sapiens >10000 ChEMBL 10.1021/acs.jmedchem.0c00435 10.7270/Q24F1V93 32345019 Tian, M; Abdelrahman, A; Baqi, Y; Fuentes, E; Azazna, D; Spanier, C; Densborn, S; Hinz, S; Schmid, R; Müller, CE University of Bonn http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50540434 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50540434&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 156015171 442141997 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51335155 Oc1ccc(Cl)cc1C(=O)Nc1cc(Cl)cc(Cl)c1 InChI=1S/C13H8Cl3NO2/c14-7-1-2-12(18)11(6-7)13(19)17-10-4-8(15)3-9(16)5-10/h1-6,18H,(H,17,19) FJIIZNKTKISOBM-UHFFFAOYSA-N 50430185 CHEMBL2179173 P2X purinoceptor 3 Homo sapiens >10000 ChEMBL 10.1021/acs.jmedchem.0c00435 10.7270/Q24F1V93 32345019 Tian, M; Abdelrahman, A; Baqi, Y; Fuentes, E; Azazna, D; Spanier, C; Densborn, S; Hinz, S; Schmid, R; Müller, CE University of Bonn http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50430185 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50430185&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 2804666 164159060 CHEMBL2179173 ZINC00139704 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51335156 Oc1ccc(Cl)cc1C(=O)Nc1cc(F)cc(F)c1 InChI=1S/C13H8ClF2NO2/c14-7-1-2-12(18)11(3-7)13(19)17-10-5-8(15)4-9(16)6-10/h1-6,18H,(H,17,19) FRVRBHNCPAKNHJ-UHFFFAOYSA-N 50540436 CHEMBL2179174 P2X purinoceptor 3 Homo sapiens >10000 ChEMBL 10.1021/acs.jmedchem.0c00435 10.7270/Q24F1V93 32345019 Tian, M; Abdelrahman, A; Baqi, Y; Fuentes, E; Azazna, D; Spanier, C; Densborn, S; Hinz, S; Schmid, R; Müller, CE University of Bonn http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50540436 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50540436&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 29035588 442141999 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51335157 Oc1ccc(Cl)cc1C(=O)Nc1cccc(Cl)c1 InChI=1S/C13H9Cl2NO2/c14-8-2-1-3-10(6-8)16-13(18)11-7-9(15)4-5-12(11)17/h1-7,17H,(H,16,18) NXDGLRGDIKDWIF-UHFFFAOYSA-N 50540442 CHEMBL2088011 P2X purinoceptor 3 Homo sapiens >10000 ChEMBL 10.1021/acs.jmedchem.0c00435 10.7270/Q24F1V93 32345019 Tian, M; Abdelrahman, A; Baqi, Y; Fuentes, E; Azazna, D; Spanier, C; Densborn, S; Hinz, S; Schmid, R; Müller, CE University of Bonn http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50540442 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50540442&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 20196 442142005 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51393263 CC(C)Oc1ccc(Nc2nc(=O)n(C(C)C)c(=O)n2Cc2ccc(Cl)cc2)cc1 InChI=1S/C22H25ClN4O3/c1-14(2)27-21(28)25-20(24-18-9-11-19(12-10-18)30-15(3)4)26(22(27)29)13-16-5-7-17(23)8-6-16/h5-12,14-15H,13H2,1-4H3,(H,24,25,28) KRYNINNUFDZTED-UHFFFAOYSA-N 183089 US9150546, I-200::US9688643, I-200::US9718790, I-0200 P2X purinoceptor 3 Homo sapiens 128 ChEMBL 10.1016/j.bmcl.2021.127833 10.7270/Q2V40ZXF 33540044 Kai, H; Horiguchi, T; Kameyama, T; Asahi, K; Endoh, T; Jikihara, S; Hasegawa, T; Tanaka, S; Nozu, A; Takeyama, C; Tomari, M; Takahashi, F; Tamura, N; Yagi, S; Itoh, T; Isou, Y Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183089 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183089&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821207 313634489 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51393264 CC(C)Oc1ccc(cc1)C(=O)Nc1nc(=O)n(C(C)C)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C23H25ClN4O4/c1-14(2)28-22(30)26-21(27(23(28)31)13-16-5-9-18(24)10-6-16)25-20(29)17-7-11-19(12-8-17)32-15(3)4/h5-12,14-15H,13H2,1-4H3,(H,25,26,29,30) RVNYISAHUMDISY-UHFFFAOYSA-N 50563035 CHEMBL4778429 P2X purinoceptor 3 Homo sapiens >1000 ChEMBL 10.1016/j.bmcl.2021.127833 10.7270/Q2V40ZXF 33540044 Kai, H; Horiguchi, T; Kameyama, T; Asahi, K; Endoh, T; Jikihara, S; Hasegawa, T; Tanaka, S; Nozu, A; Takeyama, C; Tomari, M; Takahashi, F; Tamura, N; Yagi, S; Itoh, T; Isou, Y Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50563035 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50563035&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 162644140 461683373 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51393265 CCn1c(=O)nc(Nc2ccc(OC(C)C)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C21H23ClN4O3/c1-4-25-20(27)24-19(23-17-9-11-18(12-10-17)29-14(2)3)26(21(25)28)13-15-5-7-16(22)8-6-15/h5-12,14H,4,13H2,1-3H3,(H,23,24,27) OCHZWSSISNVUCZ-UHFFFAOYSA-N 50563036 CHEMBL4787960 P2X purinoceptor 3 Homo sapiens 149 ChEMBL 10.1016/j.bmcl.2021.127833 10.7270/Q2V40ZXF 33540044 Kai, H; Horiguchi, T; Kameyama, T; Asahi, K; Endoh, T; Jikihara, S; Hasegawa, T; Tanaka, S; Nozu, A; Takeyama, C; Tomari, M; Takahashi, F; Tamura, N; Yagi, S; Itoh, T; Isou, Y Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50563036 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50563036&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 162669490 461683374 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51393266 CCn1c(=O)nc(Cc2ccc(OC(C)C)cc2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C22H24ClN3O3/c1-4-25-21(27)24-20(13-16-7-11-19(12-8-16)29-15(2)3)26(22(25)28)14-17-5-9-18(23)10-6-17/h5-12,15H,4,13-14H2,1-3H3 YSQGRHFGMJDVDB-UHFFFAOYSA-N 50563037 CHEMBL4797969 P2X purinoceptor 3 Homo sapiens >1000 ChEMBL 10.1016/j.bmcl.2021.127833 10.7270/Q2V40ZXF 33540044 Kai, H; Horiguchi, T; Kameyama, T; Asahi, K; Endoh, T; Jikihara, S; Hasegawa, T; Tanaka, S; Nozu, A; Takeyama, C; Tomari, M; Takahashi, F; Tamura, N; Yagi, S; Itoh, T; Isou, Y Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50563037 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50563037&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 162674611 461683375 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51393267 CC(C)Oc1ccc(Nc2nc(=O)n(CCO)c(=O)n2Cc2ccc(Cl)cc2)cc1 InChI=1S/C21H23ClN4O4/c1-14(2)30-18-9-7-17(8-10-18)23-19-24-20(28)25(11-12-27)21(29)26(19)13-15-3-5-16(22)6-4-15/h3-10,14,27H,11-13H2,1-2H3,(H,23,24,28) WNEKFDBSKZECEH-UHFFFAOYSA-N 183160 US9150546, I-320::US9688643, I-320::US9718790, I-0320 P2X purinoceptor 3 Homo sapiens 83 ChEMBL 10.1016/j.bmcl.2021.127833 10.7270/Q2V40ZXF 33540044 Kai, H; Horiguchi, T; Kameyama, T; Asahi, K; Endoh, T; Jikihara, S; Hasegawa, T; Tanaka, S; Nozu, A; Takeyama, C; Tomari, M; Takahashi, F; Tamura, N; Yagi, S; Itoh, T; Isou, Y Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183160 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183160&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821401 313634560 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51393268 CC(C)Oc1ccc(Oc2nc(=O)n(CCO)c(=O)n2Cc2ccc(Cl)cc2)cc1 InChI=1S/C21H22ClN3O5/c1-14(2)29-17-7-9-18(10-8-17)30-20-23-19(27)24(11-12-26)21(28)25(20)13-15-3-5-16(22)6-4-15/h3-10,14,26H,11-13H2,1-2H3 NAOFAQKIAWFMDS-UHFFFAOYSA-N 50563038 CHEMBL4753465 P2X purinoceptor 3 Homo sapiens >3000 ChEMBL 10.1016/j.bmcl.2021.127833 10.7270/Q2V40ZXF 33540044 Kai, H; Horiguchi, T; Kameyama, T; Asahi, K; Endoh, T; Jikihara, S; Hasegawa, T; Tanaka, S; Nozu, A; Takeyama, C; Tomari, M; Takahashi, F; Tamura, N; Yagi, S; Itoh, T; Isou, Y Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50563038 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50563038&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 162653942 461683376 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51393269 CC(C)n1c(=O)nc(Nc2cccc(c2)C(F)(F)F)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C20H18ClF3N4O2/c1-12(2)28-18(29)26-17(25-16-5-3-4-14(10-16)20(22,23)24)27(19(28)30)11-13-6-8-15(21)9-7-13/h3-10,12H,11H2,1-2H3,(H,25,26,29) UUGKLNMQRWYVRO-UHFFFAOYSA-N 183070 US9150546, I-020::US9688643, I-020::US9718790, I-0020 P2X purinoceptor 3 Homo sapiens 389 ChEMBL 10.1016/j.bmcl.2021.127833 10.7270/Q2V40ZXF 33540044 Kai, H; Horiguchi, T; Kameyama, T; Asahi, K; Endoh, T; Jikihara, S; Hasegawa, T; Tanaka, S; Nozu, A; Takeyama, C; Tomari, M; Takahashi, F; Tamura, N; Yagi, S; Itoh, T; Isou, Y Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183070 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183070&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821112 313634470 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51393270 COC(=O)c1ccc(Nc2nc(=O)n(C(C)C)c(=O)n2Cc2ccc(Cl)cc2)cc1 InChI=1S/C21H21ClN4O4/c1-13(2)26-20(28)24-19(23-17-10-6-15(7-11-17)18(27)30-3)25(21(26)29)12-14-4-8-16(22)9-5-14/h4-11,13H,12H2,1-3H3,(H,23,24,28) UDKRZHKBWBJIRH-UHFFFAOYSA-N 183110 US9150546, I-248::US9688643, I-248::US9718790, I-0248 P2X purinoceptor 3 Homo sapiens 420 ChEMBL 10.1016/j.bmcl.2021.127833 10.7270/Q2V40ZXF 33540044 Kai, H; Horiguchi, T; Kameyama, T; Asahi, K; Endoh, T; Jikihara, S; Hasegawa, T; Tanaka, S; Nozu, A; Takeyama, C; Tomari, M; Takahashi, F; Tamura, N; Yagi, S; Itoh, T; Isou, Y Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183110 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183110&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821342 313634510 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51393271 CC(C)n1c(=O)nc(Nc2ccc(cc2)C(O)=O)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C20H19ClN4O4/c1-12(2)25-19(28)23-18(22-16-9-5-14(6-10-16)17(26)27)24(20(25)29)11-13-3-7-15(21)8-4-13/h3-10,12H,11H2,1-2H3,(H,26,27)(H,22,23,28) WHKZIDCKYOYTQQ-UHFFFAOYSA-N 50563039 CHEMBL4746738 P2X purinoceptor 3 Homo sapiens >3000 ChEMBL 10.1016/j.bmcl.2021.127833 10.7270/Q2V40ZXF 33540044 Kai, H; Horiguchi, T; Kameyama, T; Asahi, K; Endoh, T; Jikihara, S; Hasegawa, T; Tanaka, S; Nozu, A; Takeyama, C; Tomari, M; Takahashi, F; Tamura, N; Yagi, S; Itoh, T; Isou, Y Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50563039 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50563039&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 56655623 461683377 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51393272 CC(C)NC(=O)c1ccc(Nc2nc(=O)n(C(C)C)c(=O)n2Cc2ccc(Cl)cc2)cc1 InChI=1S/C23H26ClN5O3/c1-14(2)25-20(30)17-7-11-19(12-8-17)26-21-27-22(31)29(15(3)4)23(32)28(21)13-16-5-9-18(24)10-6-16/h5-12,14-15H,13H2,1-4H3,(H,25,30)(H,26,27,31) SIGZERSAIQXHMB-UHFFFAOYSA-N 183112 US9150546, I-255::US9688643, I-255::US9718790, I-0255 P2X purinoceptor 3 Homo sapiens 520 ChEMBL 10.1016/j.bmcl.2021.127833 10.7270/Q2V40ZXF 33540044 Kai, H; Horiguchi, T; Kameyama, T; Asahi, K; Endoh, T; Jikihara, S; Hasegawa, T; Tanaka, S; Nozu, A; Takeyama, C; Tomari, M; Takahashi, F; Tamura, N; Yagi, S; Itoh, T; Isou, Y Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183112 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183112&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821432 313634512 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51393273 CC(C)Oc1ccc(Nc2nc(=O)n(C(C)C)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C22H24ClFN4O3/c1-13(2)28-21(29)26-20(25-17-9-10-19(18(24)11-17)31-14(3)4)27(22(28)30)12-15-5-7-16(23)8-6-15/h5-11,13-14H,12H2,1-4H3,(H,25,26,29) NEEKIVKPSARQCC-UHFFFAOYSA-N 183107 US9150546, I-244::US9688643, I-244::US9718790, I-0244 P2X purinoceptor 3 Homo sapiens 45 ChEMBL 10.1016/j.bmcl.2021.127833 10.7270/Q2V40ZXF 33540044 Kai, H; Horiguchi, T; Kameyama, T; Asahi, K; Endoh, T; Jikihara, S; Hasegawa, T; Tanaka, S; Nozu, A; Takeyama, C; Tomari, M; Takahashi, F; Tamura, N; Yagi, S; Itoh, T; Isou, Y Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183107 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183107&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821359 313634507 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51393274 CC(C)Oc1ccc(Nc2nc(=O)n(C(C)C)c(=O)n2Cc2ccc(Cl)cc2)cc1Cl InChI=1S/C22H24Cl2N4O3/c1-13(2)28-21(29)26-20(25-17-9-10-19(18(24)11-17)31-14(3)4)27(22(28)30)12-15-5-7-16(23)8-6-15/h5-11,13-14H,12H2,1-4H3,(H,25,26,29) VRNDXKXJUGXSQA-UHFFFAOYSA-N 183097 US9150546, I-228::US9688643, I-228::US9718790, I-0228 P2X purinoceptor 3 Homo sapiens 31 ChEMBL 10.1016/j.bmcl.2021.127833 10.7270/Q2V40ZXF 33540044 Kai, H; Horiguchi, T; Kameyama, T; Asahi, K; Endoh, T; Jikihara, S; Hasegawa, T; Tanaka, S; Nozu, A; Takeyama, C; Tomari, M; Takahashi, F; Tamura, N; Yagi, S; Itoh, T; Isou, Y Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183097 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183097&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821066 313634497 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51393275 COc1ccc(Nc2nc(=O)n(C(C)C)c(=O)n2Cc2ccc(Cl)cc2)cc1Cl InChI=1S/C20H20Cl2N4O3/c1-12(2)26-19(27)24-18(23-15-8-9-17(29-3)16(22)10-15)25(20(26)28)11-13-4-6-14(21)7-5-13/h4-10,12H,11H2,1-3H3,(H,23,24,27) MOCLUEIBJVFEID-UHFFFAOYSA-N 183106 US9150546, I-243::US9688643, I-243::US9718790, I-0243 P2X purinoceptor 3 Homo sapiens 450 ChEMBL 10.1016/j.bmcl.2021.127833 10.7270/Q2V40ZXF 33540044 Kai, H; Horiguchi, T; Kameyama, T; Asahi, K; Endoh, T; Jikihara, S; Hasegawa, T; Tanaka, S; Nozu, A; Takeyama, C; Tomari, M; Takahashi, F; Tamura, N; Yagi, S; Itoh, T; Isou, Y Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183106 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183106&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821167 313634506 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51393276 CC(C)n1c(=O)nc(Nc2ccc(Oc3ccccc3)c(Cl)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C25H22Cl2N4O3/c1-16(2)31-24(32)29-23(30(25(31)33)15-17-8-10-18(26)11-9-17)28-19-12-13-22(21(27)14-19)34-20-6-4-3-5-7-20/h3-14,16H,15H2,1-2H3,(H,28,29,32) NFSZOFAKVQXYIY-UHFFFAOYSA-N 183103 US9150546, I-240::US9688643, I-240 P2X purinoceptor 3 Homo sapiens 953 ChEMBL 10.1016/j.bmcl.2021.127833 10.7270/Q2V40ZXF 33540044 Kai, H; Horiguchi, T; Kameyama, T; Asahi, K; Endoh, T; Jikihara, S; Hasegawa, T; Tanaka, S; Nozu, A; Takeyama, C; Tomari, M; Takahashi, F; Tamura, N; Yagi, S; Itoh, T; Isou, Y Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183103 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183103&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821125 313634503 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51393277 CC(C)Oc1ccc(Nc2nc(=O)n(C(C)C)c(=O)[nH]2)cc1F InChI=1S/C15H19FN4O3/c1-8(2)20-14(21)18-13(19-15(20)22)17-10-5-6-12(11(16)7-10)23-9(3)4/h5-9H,1-4H3,(H2,17,18,19,21,22) LVOXVWFFQHSBID-UHFFFAOYSA-N 50563040 CHEMBL4757743 P2X purinoceptor 3 Homo sapiens >3000 ChEMBL 10.1016/j.bmcl.2021.127833 10.7270/Q2V40ZXF 33540044 Kai, H; Horiguchi, T; Kameyama, T; Asahi, K; Endoh, T; Jikihara, S; Hasegawa, T; Tanaka, S; Nozu, A; Takeyama, C; Tomari, M; Takahashi, F; Tamura, N; Yagi, S; Itoh, T; Isou, Y Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50563040 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50563040&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 162656594 461683378 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51393278 CC(C)Oc1ccc(Nc2nc(=O)n(C(C)C)c(=O)n2-c2ccc(Cl)s2)cc1F InChI=1S/C19H20ClFN4O3S/c1-10(2)24-18(26)23-17(25(19(24)27)16-8-7-15(20)29-16)22-12-5-6-14(13(21)9-12)28-11(3)4/h5-11H,1-4H3,(H,22,23,26) LXFXTPGZJWVCPW-UHFFFAOYSA-N 50563041 CHEMBL4746334 P2X purinoceptor 3 Homo sapiens 144 ChEMBL 10.1016/j.bmcl.2021.127833 10.7270/Q2V40ZXF 33540044 Kai, H; Horiguchi, T; Kameyama, T; Asahi, K; Endoh, T; Jikihara, S; Hasegawa, T; Tanaka, S; Nozu, A; Takeyama, C; Tomari, M; Takahashi, F; Tamura, N; Yagi, S; Itoh, T; Isou, Y Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50563041 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50563041&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 162648742 461683379 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51393279 CC#CCn1c(Nc2ccc(OC(C)C)c(F)c2)nc(=O)n(C(C)C)c1=O InChI=1S/C19H23FN4O3/c1-6-7-10-23-17(22-18(25)24(12(2)3)19(23)26)21-14-8-9-16(15(20)11-14)27-13(4)5/h8-9,11-13H,10H2,1-5H3,(H,21,22,25) NOIAAZAPMZPBID-UHFFFAOYSA-N 50563042 CHEMBL4783380 P2X purinoceptor 3 Homo sapiens >3000 ChEMBL 10.1016/j.bmcl.2021.127833 10.7270/Q2V40ZXF 33540044 Kai, H; Horiguchi, T; Kameyama, T; Asahi, K; Endoh, T; Jikihara, S; Hasegawa, T; Tanaka, S; Nozu, A; Takeyama, C; Tomari, M; Takahashi, F; Tamura, N; Yagi, S; Itoh, T; Isou, Y Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50563042 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50563042&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578433 461683380 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51393280 CC(C)Oc1ccc(Nc2nc(=O)n(C(C)C)c(=O)n2CC2CC2)cc1F InChI=1S/C19H25FN4O3/c1-11(2)24-18(25)22-17(23(19(24)26)10-13-5-6-13)21-14-7-8-16(15(20)9-14)27-12(3)4/h7-9,11-13H,5-6,10H2,1-4H3,(H,21,22,25) BVVQRBARBINEHC-UHFFFAOYSA-N 50563043 CHEMBL4759101 P2X purinoceptor 3 Homo sapiens >3000 ChEMBL 10.1016/j.bmcl.2021.127833 10.7270/Q2V40ZXF 33540044 Kai, H; Horiguchi, T; Kameyama, T; Asahi, K; Endoh, T; Jikihara, S; Hasegawa, T; Tanaka, S; Nozu, A; Takeyama, C; Tomari, M; Takahashi, F; Tamura, N; Yagi, S; Itoh, T; Isou, Y Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50563043 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50563043&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578475 461683381 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51393281 COc1ccc(cc1)-n1c(Nc2ccc(OC(C)C)c(F)c2)nc(=O)n(C(C)C)c1=O InChI=1S/C22H25FN4O4/c1-13(2)26-21(28)25-20(24-15-6-11-19(18(23)12-15)31-14(3)4)27(22(26)29)16-7-9-17(30-5)10-8-16/h6-14H,1-5H3,(H,24,25,28) GFUZRYXWDRWCOJ-UHFFFAOYSA-N 50563044 CHEMBL4743578 P2X purinoceptor 3 Homo sapiens >3000 ChEMBL 10.1016/j.bmcl.2021.127833 10.7270/Q2V40ZXF 33540044 Kai, H; Horiguchi, T; Kameyama, T; Asahi, K; Endoh, T; Jikihara, S; Hasegawa, T; Tanaka, S; Nozu, A; Takeyama, C; Tomari, M; Takahashi, F; Tamura, N; Yagi, S; Itoh, T; Isou, Y Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50563044 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50563044&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 162647367 461683382 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51393282 CC(C)Oc1ccc(Nc2nc(=O)n(C(C)C)c(=O)n2-c2ccc(Cl)cc2)cc1F InChI=1S/C21H22ClFN4O3/c1-12(2)26-20(28)25-19(27(21(26)29)16-8-5-14(22)6-9-16)24-15-7-10-18(17(23)11-15)30-13(3)4/h5-13H,1-4H3,(H,24,25,28) POAOFZNYTLQHEJ-UHFFFAOYSA-N 50563045 CHEMBL4797152 P2X purinoceptor 3 Homo sapiens >3000 ChEMBL 10.1016/j.bmcl.2021.127833 10.7270/Q2V40ZXF 33540044 Kai, H; Horiguchi, T; Kameyama, T; Asahi, K; Endoh, T; Jikihara, S; Hasegawa, T; Tanaka, S; Nozu, A; Takeyama, C; Tomari, M; Takahashi, F; Tamura, N; Yagi, S; Itoh, T; Isou, Y Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50563045 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50563045&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 162675380 461683383 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51393283 CC(C)Oc1ccc(Nc2nc(=O)n(C(C)C)c(=O)n2CC(=O)N(C)C)cc1F InChI=1S/C19H26FN5O4/c1-11(2)25-18(27)22-17(24(19(25)28)10-16(26)23(5)6)21-13-7-8-15(14(20)9-13)29-12(3)4/h7-9,11-12H,10H2,1-6H3,(H,21,22,27) TZTOOUJPKQXRIK-UHFFFAOYSA-N 50563046 CHEMBL4750072 P2X purinoceptor 3 Homo sapiens >3000 ChEMBL 10.1016/j.bmcl.2021.127833 10.7270/Q2V40ZXF 33540044 Kai, H; Horiguchi, T; Kameyama, T; Asahi, K; Endoh, T; Jikihara, S; Hasegawa, T; Tanaka, S; Nozu, A; Takeyama, C; Tomari, M; Takahashi, F; Tamura, N; Yagi, S; Itoh, T; Isou, Y Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50563046 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50563046&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 162651448 461683384 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51393284 CC(C)Oc1ccc(Nc2nc(=O)n(C(C)C)c(=O)n2CC(=O)N2CCOCC2)cc1F InChI=1S/C21H28FN5O5/c1-13(2)27-20(29)24-19(23-15-5-6-17(16(22)11-15)32-14(3)4)26(21(27)30)12-18(28)25-7-9-31-10-8-25/h5-6,11,13-14H,7-10,12H2,1-4H3,(H,23,24,29) PSYPFPBBHBDLFF-UHFFFAOYSA-N 50563047 CHEMBL4750833 P2X purinoceptor 3 Homo sapiens >3000 ChEMBL 10.1016/j.bmcl.2021.127833 10.7270/Q2V40ZXF 33540044 Kai, H; Horiguchi, T; Kameyama, T; Asahi, K; Endoh, T; Jikihara, S; Hasegawa, T; Tanaka, S; Nozu, A; Takeyama, C; Tomari, M; Takahashi, F; Tamura, N; Yagi, S; Itoh, T; Isou, Y Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50563047 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50563047&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 162652306 461683385 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51393285 CC(C)Oc1ccc(Nc2nc(=O)[nH]c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C19H18ClFN4O3/c1-11(2)28-16-8-7-14(9-15(16)21)22-17-23-18(26)24-19(27)25(17)10-12-3-5-13(20)6-4-12/h3-9,11H,10H2,1-2H3,(H2,22,23,24,26,27) AJVAAPSNYAVHDF-UHFFFAOYSA-N 183117 US9150546, I-269::US9688643, I-269::US9718790, I-0269 P2X purinoceptor 3 Homo sapiens 415 ChEMBL 10.1016/j.bmcl.2021.127833 10.7270/Q2V40ZXF 33540044 Kai, H; Horiguchi, T; Kameyama, T; Asahi, K; Endoh, T; Jikihara, S; Hasegawa, T; Tanaka, S; Nozu, A; Takeyama, C; Tomari, M; Takahashi, F; Tamura, N; Yagi, S; Itoh, T; Isou, Y Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183117 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183117&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76820948 313634517 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51393286 CCn1c(=O)nc(Nc2ccc(OC(C)C)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C21H22ClFN4O3/c1-4-26-20(28)25-19(24-16-9-10-18(17(23)11-16)30-13(2)3)27(21(26)29)12-14-5-7-15(22)8-6-14/h5-11,13H,4,12H2,1-3H3,(H,24,25,28) ZFOLLFDANAKBTB-UHFFFAOYSA-N 183125 US9150546, I-277::US9688643, I-277::US9718790, I-0277 P2X purinoceptor 3 Homo sapiens 38 ChEMBL 10.1016/j.bmcl.2021.127833 10.7270/Q2V40ZXF 33540044 Kai, H; Horiguchi, T; Kameyama, T; Asahi, K; Endoh, T; Jikihara, S; Hasegawa, T; Tanaka, S; Nozu, A; Takeyama, C; Tomari, M; Takahashi, F; Tamura, N; Yagi, S; Itoh, T; Isou, Y Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183125 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183125&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821275 313634525 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51393287 CCCn1c(=O)nc(Nc2ccc(OC(C)C)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C22H24ClFN4O3/c1-4-11-27-21(29)26-20(25-17-9-10-19(18(24)12-17)31-14(2)3)28(22(27)30)13-15-5-7-16(23)8-6-15/h5-10,12,14H,4,11,13H2,1-3H3,(H,25,26,29) JPYJUMSFDCRFTJ-UHFFFAOYSA-N 183184 US9150546, I-348::US9688643, I-348::US9718790, I-0348 P2X purinoceptor 3 Homo sapiens 13 ChEMBL 10.1016/j.bmcl.2021.127833 10.7270/Q2V40ZXF 33540044 Kai, H; Horiguchi, T; Kameyama, T; Asahi, K; Endoh, T; Jikihara, S; Hasegawa, T; Tanaka, S; Nozu, A; Takeyama, C; Tomari, M; Takahashi, F; Tamura, N; Yagi, S; Itoh, T; Isou, Y Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183184 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183184&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821127 313634584 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51393288 CC(C)Oc1ccc(Nc2nc(=O)n(Cc3ccccc3)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C26H24ClFN4O3/c1-17(2)35-23-13-12-21(14-22(23)28)29-24-30-25(33)32(16-18-6-4-3-5-7-18)26(34)31(24)15-19-8-10-20(27)11-9-19/h3-14,17H,15-16H2,1-2H3,(H,29,30,33) CRXFJQFRHPYGEW-UHFFFAOYSA-N 183148 US9150546, I-301::US9688643, I-301::US9718790, I-0301 P2X purinoceptor 3 Homo sapiens 48 ChEMBL 10.1016/j.bmcl.2021.127833 10.7270/Q2V40ZXF 33540044 Kai, H; Horiguchi, T; Kameyama, T; Asahi, K; Endoh, T; Jikihara, S; Hasegawa, T; Tanaka, S; Nozu, A; Takeyama, C; Tomari, M; Takahashi, F; Tamura, N; Yagi, S; Itoh, T; Isou, Y Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183148 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183148&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821148 313634548 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51393289 CC(C)Oc1ccc(Nc2nc(=O)n(CC#N)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C21H19ClFN5O3/c1-13(2)31-18-8-7-16(11-17(18)23)25-19-26-20(29)27(10-9-24)21(30)28(19)12-14-3-5-15(22)6-4-14/h3-8,11,13H,10,12H2,1-2H3,(H,25,26,29) SHZBDZQJVOICIK-UHFFFAOYSA-N 183135 US9150546, I-288::US9688643, I-288::US9718790, I-0288 P2X purinoceptor 3 Homo sapiens 93 ChEMBL 10.1016/j.bmcl.2021.127833 10.7270/Q2V40ZXF 33540044 Kai, H; Horiguchi, T; Kameyama, T; Asahi, K; Endoh, T; Jikihara, S; Hasegawa, T; Tanaka, S; Nozu, A; Takeyama, C; Tomari, M; Takahashi, F; Tamura, N; Yagi, S; Itoh, T; Isou, Y Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183135 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183135&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821284 313634535 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51393290 CC(C)Oc1ccc(Nc2nc(=O)n(CCC#N)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C22H21ClFN5O3/c1-14(2)32-19-9-8-17(12-18(19)24)26-20-27-21(30)28(11-3-10-25)22(31)29(20)13-15-4-6-16(23)7-5-15/h4-9,12,14H,3,11,13H2,1-2H3,(H,26,27,30) MUAVUCGFIWKKLX-UHFFFAOYSA-N 183138 US9150546, I-291::US9688643, I-291::US9718790, I-0291 P2X purinoceptor 3 Homo sapiens 9.1 ChEMBL 10.1016/j.bmcl.2021.127833 10.7270/Q2V40ZXF 33540044 Kai, H; Horiguchi, T; Kameyama, T; Asahi, K; Endoh, T; Jikihara, S; Hasegawa, T; Tanaka, S; Nozu, A; Takeyama, C; Tomari, M; Takahashi, F; Tamura, N; Yagi, S; Itoh, T; Isou, Y Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183138 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183138&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821316 313634538 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51393291 CC(C)Oc1ccc(Nc2nc(=O)n(C(C)=O)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C21H20ClFN4O4/c1-12(2)31-18-9-8-16(10-17(18)23)24-19-25-20(29)27(13(3)28)21(30)26(19)11-14-4-6-15(22)7-5-14/h4-10,12H,11H2,1-3H3,(H,24,25,29) TZVHQOORWPGESA-UHFFFAOYSA-N 183143 US9150546, I-296::US9688643, I-296::US9718790, I-0296 P2X purinoceptor 3 Homo sapiens 176 ChEMBL 10.1016/j.bmcl.2021.127833 10.7270/Q2V40ZXF 33540044 Kai, H; Horiguchi, T; Kameyama, T; Asahi, K; Endoh, T; Jikihara, S; Hasegawa, T; Tanaka, S; Nozu, A; Takeyama, C; Tomari, M; Takahashi, F; Tamura, N; Yagi, S; Itoh, T; Isou, Y Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183143 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183143&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821385 313634543 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51393292 CC(C)Oc1ccc(Nc2nc(=O)n(CCO)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C21H22ClFN4O4/c1-13(2)31-18-8-7-16(11-17(18)23)24-19-25-20(29)26(9-10-28)21(30)27(19)12-14-3-5-15(22)6-4-14/h3-8,11,13,28H,9-10,12H2,1-2H3,(H,24,25,29) XKUBPFCGXISTNR-UHFFFAOYSA-N 183121 US9150546, I-273::US9688643, I-273::US9718790, I-0273 P2X purinoceptor 3 Homo sapiens 38 ChEMBL 10.1016/j.bmcl.2021.127833 10.7270/Q2V40ZXF 33540044 Kai, H; Horiguchi, T; Kameyama, T; Asahi, K; Endoh, T; Jikihara, S; Hasegawa, T; Tanaka, S; Nozu, A; Takeyama, C; Tomari, M; Takahashi, F; Tamura, N; Yagi, S; Itoh, T; Isou, Y Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183121 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183121&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821279 313634521 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51393293 CC(C)Oc1ccc(Nc2nc(=O)n(CCCO)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C22H24ClFN4O4/c1-14(2)32-19-9-8-17(12-18(19)24)25-20-26-21(30)27(10-3-11-29)22(31)28(20)13-15-4-6-16(23)7-5-15/h4-9,12,14,29H,3,10-11,13H2,1-2H3,(H,25,26,30) NOTRDLDWXSPKCF-UHFFFAOYSA-N 183132 US9150546, I-285::US9688643, I-285::US9718790, I-0285 P2X purinoceptor 3 Homo sapiens 14 ChEMBL 10.1016/j.bmcl.2021.127833 10.7270/Q2V40ZXF 33540044 Kai, H; Horiguchi, T; Kameyama, T; Asahi, K; Endoh, T; Jikihara, S; Hasegawa, T; Tanaka, S; Nozu, A; Takeyama, C; Tomari, M; Takahashi, F; Tamura, N; Yagi, S; Itoh, T; Isou, Y Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183132 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183132&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821080 313634532 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51393294 CC(C)Oc1ccc(Nc2nc(=O)n(CCCCO)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C23H26ClFN4O4/c1-15(2)33-20-10-9-18(13-19(20)25)26-21-27-22(31)28(11-3-4-12-30)23(32)29(21)14-16-5-7-17(24)8-6-16/h5-10,13,15,30H,3-4,11-12,14H2,1-2H3,(H,26,27,31) WIVQLHRBUYZELM-UHFFFAOYSA-N 183201 US9150546, I-365::US9688643, I-365::US9718790, I-0365 P2X purinoceptor 3 Homo sapiens 18 ChEMBL 10.1016/j.bmcl.2021.127833 10.7270/Q2V40ZXF 33540044 Kai, H; Horiguchi, T; Kameyama, T; Asahi, K; Endoh, T; Jikihara, S; Hasegawa, T; Tanaka, S; Nozu, A; Takeyama, C; Tomari, M; Takahashi, F; Tamura, N; Yagi, S; Itoh, T; Isou, Y Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183201 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183201&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821405 313634601 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51393295 CC(C)Oc1ccc(Nc2nc(=O)n(CCNC(C)=O)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C23H25ClFN5O4/c1-14(2)34-20-9-8-18(12-19(20)25)27-21-28-22(32)29(11-10-26-15(3)31)23(33)30(21)13-16-4-6-17(24)7-5-16/h4-9,12,14H,10-11,13H2,1-3H3,(H,26,31)(H,27,28,32) VLKNEIAWFTVSEB-UHFFFAOYSA-N 183139 US9150546, I-292::US9688643, I-292::US9718790, I-0292 P2X purinoceptor 3 Homo sapiens 34 ChEMBL 10.1016/j.bmcl.2021.127833 10.7270/Q2V40ZXF 33540044 Kai, H; Horiguchi, T; Kameyama, T; Asahi, K; Endoh, T; Jikihara, S; Hasegawa, T; Tanaka, S; Nozu, A; Takeyama, C; Tomari, M; Takahashi, F; Tamura, N; Yagi, S; Itoh, T; Isou, Y Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183139 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183139&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 77393823 313634539 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51393296 CC(C)Oc1ccc(Nc2nc(=O)n(CCCNC(C)=O)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C24H27ClFN5O4/c1-15(2)35-21-10-9-19(13-20(21)26)28-22-29-23(33)30(12-4-11-27-16(3)32)24(34)31(22)14-17-5-7-18(25)8-6-17/h5-10,13,15H,4,11-12,14H2,1-3H3,(H,27,32)(H,28,29,33) IFZZAWGUWRJMDO-UHFFFAOYSA-N 183166 US9150546, I-326::US9688643, I-326::US9718790, I-0326 P2X purinoceptor 3 Homo sapiens 11 ChEMBL 10.1016/j.bmcl.2021.127833 10.7270/Q2V40ZXF 33540044 Kai, H; Horiguchi, T; Kameyama, T; Asahi, K; Endoh, T; Jikihara, S; Hasegawa, T; Tanaka, S; Nozu, A; Takeyama, C; Tomari, M; Takahashi, F; Tamura, N; Yagi, S; Itoh, T; Isou, Y Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183166 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183166&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821044 313634566 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51393297 CC(C)Oc1ccc(Nc2nc(=O)n(CC(O)=O)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C21H20ClFN4O5/c1-12(2)32-17-8-7-15(9-16(17)23)24-19-25-20(30)27(11-18(28)29)21(31)26(19)10-13-3-5-14(22)6-4-13/h3-9,12H,10-11H2,1-2H3,(H,28,29)(H,24,25,30) PLIWLWCQSVFBEL-UHFFFAOYSA-N 183131 US9150546, I-284::US9688643, I-284::US9718790, I-0284 P2X purinoceptor 3 Homo sapiens 629 ChEMBL 10.1016/j.bmcl.2021.127833 10.7270/Q2V40ZXF 33540044 Kai, H; Horiguchi, T; Kameyama, T; Asahi, K; Endoh, T; Jikihara, S; Hasegawa, T; Tanaka, S; Nozu, A; Takeyama, C; Tomari, M; Takahashi, F; Tamura, N; Yagi, S; Itoh, T; Isou, Y Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183131 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183131&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76820980 313634531 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51393298 CC(C)Oc1ccc(Nc2nc(=O)n(CCC(O)=O)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C22H22ClFN4O5/c1-13(2)33-18-8-7-16(11-17(18)24)25-20-26-21(31)27(10-9-19(29)30)22(32)28(20)12-14-3-5-15(23)6-4-14/h3-8,11,13H,9-10,12H2,1-2H3,(H,29,30)(H,25,26,31) MCTZNTUJEJXMFG-UHFFFAOYSA-N 183136 US9150546, I-289::US9688643, I-289::US9718790, I-0289 P2X purinoceptor 3 Homo sapiens 66 ChEMBL 10.1016/j.bmcl.2021.127833 10.7270/Q2V40ZXF 33540044 Kai, H; Horiguchi, T; Kameyama, T; Asahi, K; Endoh, T; Jikihara, S; Hasegawa, T; Tanaka, S; Nozu, A; Takeyama, C; Tomari, M; Takahashi, F; Tamura, N; Yagi, S; Itoh, T; Isou, Y Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183136 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183136&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821389 313634536 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51393299 CC(C)Oc1ccc(Nc2nc(=O)n(CCCC(O)=O)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C23H24ClFN4O5/c1-14(2)34-19-10-9-17(12-18(19)25)26-21-27-22(32)28(11-3-4-20(30)31)23(33)29(21)13-15-5-7-16(24)8-6-15/h5-10,12,14H,3-4,11,13H2,1-2H3,(H,30,31)(H,26,27,32) PRGQUPCLZCUZSW-UHFFFAOYSA-N 183199 US9150546, I-363::US9688643, I-363::US9718790, I-0363 P2X purinoceptor 3 Homo sapiens 78 ChEMBL 10.1016/j.bmcl.2021.127833 10.7270/Q2V40ZXF 33540044 Kai, H; Horiguchi, T; Kameyama, T; Asahi, K; Endoh, T; Jikihara, S; Hasegawa, T; Tanaka, S; Nozu, A; Takeyama, C; Tomari, M; Takahashi, F; Tamura, N; Yagi, S; Itoh, T; Isou, Y Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183199 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183199&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821307 313634599 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51393300 CC(C)Oc1ccc(Nc2nc(=O)n(CCC(N)=O)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C22H23ClFN5O4/c1-13(2)33-18-8-7-16(11-17(18)24)26-20-27-21(31)28(10-9-19(25)30)22(32)29(20)12-14-3-5-15(23)6-4-14/h3-8,11,13H,9-10,12H2,1-2H3,(H2,25,30)(H,26,27,31) UFFMZHJMYPBKRN-UHFFFAOYSA-N 183146 US9150546, I-299::US9688643, I-299::US9718790, I-0299 P2X purinoceptor 3 Homo sapiens 46 ChEMBL 10.1016/j.bmcl.2021.127833 10.7270/Q2V40ZXF 33540044 Kai, H; Horiguchi, T; Kameyama, T; Asahi, K; Endoh, T; Jikihara, S; Hasegawa, T; Tanaka, S; Nozu, A; Takeyama, C; Tomari, M; Takahashi, F; Tamura, N; Yagi, S; Itoh, T; Isou, Y Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183146 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183146&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821155 313634546 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51393301 CNC(=O)CCn1c(=O)nc(Nc2ccc(OC(C)C)c(F)c2)n(Cc2ccc(Cl)cc2)c1=O InChI=1S/C23H25ClFN5O4/c1-14(2)34-19-9-8-17(12-18(19)25)27-21-28-22(32)29(11-10-20(31)26-3)23(33)30(21)13-15-4-6-16(24)7-5-15/h4-9,12,14H,10-11,13H2,1-3H3,(H,26,31)(H,27,28,32) XGSOCLWAPUYZQU-UHFFFAOYSA-N 183145 US9150546, I-298::US9688643, I-298::US9718790, I-0298 P2X purinoceptor 3 Homo sapiens 27 ChEMBL 10.1016/j.bmcl.2021.127833 10.7270/Q2V40ZXF 33540044 Kai, H; Horiguchi, T; Kameyama, T; Asahi, K; Endoh, T; Jikihara, S; Hasegawa, T; Tanaka, S; Nozu, A; Takeyama, C; Tomari, M; Takahashi, F; Tamura, N; Yagi, S; Itoh, T; Isou, Y Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183145 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183145&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821333 313634545 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51393302 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(CC(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C21H20Cl2N4O5/c1-12(2)32-17-8-7-15(9-16(17)23)24-19-25-20(30)27(11-18(28)29)21(31)26(19)10-13-3-5-14(22)6-4-13/h3-9,12H,10-11H2,1-2H3,(H,28,29)(H,24,25,30) VEMXKDNCOMOECJ-UHFFFAOYSA-N 183266 US9150546, I-434::US9688643, I-434::US9718790, I-0443 P2X purinoceptor 3 Homo sapiens 20 ChEMBL 10.1016/j.bmcl.2021.127833 10.7270/Q2V40ZXF 33540044 Kai, H; Horiguchi, T; Kameyama, T; Asahi, K; Endoh, T; Jikihara, S; Hasegawa, T; Tanaka, S; Nozu, A; Takeyama, C; Tomari, M; Takahashi, F; Tamura, N; Yagi, S; Itoh, T; Isou, Y Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183266 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183266&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578367 313634666 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51393303 CC(C)Oc1ccc(Nc2nc(=O)n(CCC(O)=O)c(=O)n2Cc2ccc(Cl)cc2)cc1Cl InChI=1S/C22H22Cl2N4O5/c1-13(2)33-18-8-7-16(11-17(18)24)25-20-26-21(31)27(10-9-19(29)30)22(32)28(20)12-14-3-5-15(23)6-4-14/h3-8,11,13H,9-10,12H2,1-2H3,(H,29,30)(H,25,26,31) LTHMPYWKRCESAL-UHFFFAOYSA-N 183191 US9150546, I-355::US9688643, I-355::US9718790, I-0355 P2X purinoceptor 3 Homo sapiens 13 ChEMBL 10.1016/j.bmcl.2021.127833 10.7270/Q2V40ZXF 33540044 Kai, H; Horiguchi, T; Kameyama, T; Asahi, K; Endoh, T; Jikihara, S; Hasegawa, T; Tanaka, S; Nozu, A; Takeyama, C; Tomari, M; Takahashi, F; Tamura, N; Yagi, S; Itoh, T; Isou, Y Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183191 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183191&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821101 313634591 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51393304 CC(C)Oc1ccc(Nc2cc(=O)n(CCC(O)=O)c(=O)n2Cc2ccc(Cl)cc2)cc1Cl InChI=1S/C23H23Cl2N3O5/c1-14(2)33-19-8-7-17(11-18(19)25)26-20-12-21(29)27(10-9-22(30)31)23(32)28(20)13-15-3-5-16(24)6-4-15/h3-8,11-12,14,26H,9-10,13H2,1-2H3,(H,30,31) HPNBQEPLOMTGNM-UHFFFAOYSA-N 50563048 CHEMBL4789094 P2X purinoceptor 3 Homo sapiens 34 ChEMBL 10.1016/j.bmcl.2021.127833 10.7270/Q2V40ZXF 33540044 Kai, H; Horiguchi, T; Kameyama, T; Asahi, K; Endoh, T; Jikihara, S; Hasegawa, T; Tanaka, S; Nozu, A; Takeyama, C; Tomari, M; Takahashi, F; Tamura, N; Yagi, S; Itoh, T; Isou, Y Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50563048 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50563048&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 162668877 461683386 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51393305 CC(C)Oc1ccc(Nc2nc(=O)c(CC(O)=O)cn2Cc2ccc(Cl)cc2)cc1Cl InChI=1S/C22H21Cl2N3O4/c1-13(2)31-19-8-7-17(10-18(19)24)25-22-26-21(30)15(9-20(28)29)12-27(22)11-14-3-5-16(23)6-4-14/h3-8,10,12-13H,9,11H2,1-2H3,(H,28,29)(H,25,26,30) CQXKACXOKYWDCW-UHFFFAOYSA-N 50563049 CHEMBL4752152 P2X purinoceptor 3 Homo sapiens 152 ChEMBL 10.1016/j.bmcl.2021.127833 10.7270/Q2V40ZXF 33540044 Kai, H; Horiguchi, T; Kameyama, T; Asahi, K; Endoh, T; Jikihara, S; Hasegawa, T; Tanaka, S; Nozu, A; Takeyama, C; Tomari, M; Takahashi, F; Tamura, N; Yagi, S; Itoh, T; Isou, Y Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50563049 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50563049&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 162652624 461683387 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51393306 CC(C)Oc1ccc(Nc2ncc(CC(O)=O)c(=O)n2Cc2ccc(Cl)cc2)cc1Cl InChI=1S/C22H21Cl2N3O4/c1-13(2)31-19-8-7-17(10-18(19)24)26-22-25-11-15(9-20(28)29)21(30)27(22)12-14-3-5-16(23)6-4-14/h3-8,10-11,13H,9,12H2,1-2H3,(H,25,26)(H,28,29) JJLUUSYEHIJZTG-UHFFFAOYSA-N 50563050 CHEMBL4796811 P2X purinoceptor 3 Homo sapiens 219 ChEMBL 10.1016/j.bmcl.2021.127833 10.7270/Q2V40ZXF 33540044 Kai, H; Horiguchi, T; Kameyama, T; Asahi, K; Endoh, T; Jikihara, S; Hasegawa, T; Tanaka, S; Nozu, A; Takeyama, C; Tomari, M; Takahashi, F; Tamura, N; Yagi, S; Itoh, T; Isou, Y Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50563050 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50563050&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 162674839 461683388 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51393307 CC(C)Oc1ccc(Nc2nc(CC(O)=O)nc(=O)n2Cc2ccc(Cl)cc2)cc1Cl InChI=1S/C21H20Cl2N4O4/c1-12(2)31-17-8-7-15(9-16(17)23)24-20-25-18(10-19(28)29)26-21(30)27(20)11-13-3-5-14(22)6-4-13/h3-9,12H,10-11H2,1-2H3,(H,28,29)(H,24,25,26,30) FTYJMCHKIWUNQN-UHFFFAOYSA-N 50563051 CHEMBL4788581 P2X purinoceptor 3 Homo sapiens 614 ChEMBL 10.1016/j.bmcl.2021.127833 10.7270/Q2V40ZXF 33540044 Kai, H; Horiguchi, T; Kameyama, T; Asahi, K; Endoh, T; Jikihara, S; Hasegawa, T; Tanaka, S; Nozu, A; Takeyama, C; Tomari, M; Takahashi, F; Tamura, N; Yagi, S; Itoh, T; Isou, Y Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50563051 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50563051&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 162668512 461683389 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51393308 CC(C)Oc1ccc(Nc2nc(=O)n(CC(C)(C)C(O)=O)c(=O)n2Cc2ccc(Cl)cc2)cc1F InChI=1S/C24H26ClFN4O5/c1-14(2)35-19-10-9-17(11-18(19)26)27-21-28-22(33)30(13-24(3,4)20(31)32)23(34)29(21)12-15-5-7-16(25)8-6-15/h5-11,14H,12-13H2,1-4H3,(H,31,32)(H,27,28,33) CAYYASMSWISXDA-UHFFFAOYSA-N 183200 US9150546, I-364::US9688643, I-364::US9718790, I-0364 P2X purinoceptor 3 Homo sapiens 30 ChEMBL 10.1016/j.bmcl.2021.127833 10.7270/Q2V40ZXF 33540044 Kai, H; Horiguchi, T; Kameyama, T; Asahi, K; Endoh, T; Jikihara, S; Hasegawa, T; Tanaka, S; Nozu, A; Takeyama, C; Tomari, M; Takahashi, F; Tamura, N; Yagi, S; Itoh, T; Isou, Y Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183200 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183200&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821363 313634600 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51393309 CC(C)Oc1ccc(Nc2nc(=O)n(CCC(O)=O)c(=O)n2Cc2ccc(C)cc2)cc1Cl InChI=1S/C23H25ClN4O5/c1-14(2)33-19-9-8-17(12-18(19)24)25-21-26-22(31)27(11-10-20(29)30)23(32)28(21)13-16-6-4-15(3)5-7-16/h4-9,12,14H,10-11,13H2,1-3H3,(H,29,30)(H,25,26,31) KRHNDEFYSFIWAD-UHFFFAOYSA-N 50563052 CHEMBL4748113 P2X purinoceptor 3 Homo sapiens 16 ChEMBL 10.1016/j.bmcl.2021.127833 10.7270/Q2V40ZXF 33540044 Kai, H; Horiguchi, T; Kameyama, T; Asahi, K; Endoh, T; Jikihara, S; Hasegawa, T; Tanaka, S; Nozu, A; Takeyama, C; Tomari, M; Takahashi, F; Tamura, N; Yagi, S; Itoh, T; Isou, Y Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50563052 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50563052&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020375 461683390 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51393310 COc1cc(C(C)C)c(Oc2cnc(NC(CO)CO)nc2N)cc1I InChI=1S/C17H23IN4O4/c1-9(2)11-4-14(25-3)12(18)5-13(11)26-15-6-20-17(22-16(15)19)21-10(7-23)8-24/h4-6,9-10,23-24H,7-8H2,1-3H3,(H3,19,20,21,22) PAYROHWFGZADBR-UHFFFAOYSA-N 50257829 2-(4-amino-5-(5-iodo-2-isopropyl-4-methoxyphenoxy)pyrimidin-2-ylamino)propane-1,3-diol::CHEMBL494161::Ro-51 P2X purinoceptor 3 Homo sapiens 6.3 ChEMBL 10.1016/j.bmcl.2021.127833 10.7270/Q2V40ZXF 33540044 Kai, H; Horiguchi, T; Kameyama, T; Asahi, K; Endoh, T; Jikihara, S; Hasegawa, T; Tanaka, S; Nozu, A; Takeyama, C; Tomari, M; Takahashi, F; Tamura, N; Yagi, S; Itoh, T; Isou, Y Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50257829 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50257829&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 24883277 104108764 CHEMBL494161 ZINC40953233 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51393311 COc1cc(Oc2cnc(N)nc2N)c(cc1OC)C(C)C InChI=1S/C15H20N4O3/c1-8(2)9-5-11(20-3)12(21-4)6-10(9)22-13-7-18-15(17)19-14(13)16/h5-8H,1-4H3,(H4,16,17,18,19) QVZLKMLKJOKUHQ-UHFFFAOYSA-N 50413382 CHEMBL494833 P2X purinoceptor 3 Homo sapiens 136 ChEMBL 10.1016/j.bmcl.2021.127833 10.7270/Q2V40ZXF 33540044 Kai, H; Horiguchi, T; Kameyama, T; Asahi, K; Endoh, T; Jikihara, S; Hasegawa, T; Tanaka, S; Nozu, A; Takeyama, C; Tomari, M; Takahashi, F; Tamura, N; Yagi, S; Itoh, T; Isou, Y Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50413382 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50413382&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 44573561 163362406 CHEMBL494833 ZINC40952679 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51393312 COc1ccc(Cn2c(Nc3cccc(c3)C(F)(F)F)nc(=O)n(CC=C)c2=O)cc1 InChI=1S/C21H19F3N4O3/c1-3-11-27-19(29)26-18(25-16-6-4-5-15(12-16)21(22,23)24)28(20(27)30)13-14-7-9-17(31-2)10-8-14/h3-10,12H,1,11,13H2,2H3,(H,25,26,29) YLCXWPPDJFECQI-UHFFFAOYSA-N 50563053 CHEMBL4749540 P2X purinoceptor 3 Homo sapiens 1200 ChEMBL 10.1016/j.bmcl.2021.127833 10.7270/Q2V40ZXF 33540044 Kai, H; Horiguchi, T; Kameyama, T; Asahi, K; Endoh, T; Jikihara, S; Hasegawa, T; Tanaka, S; Nozu, A; Takeyama, C; Tomari, M; Takahashi, F; Tamura, N; Yagi, S; Itoh, T; Isou, Y Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50563053 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50563053&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578701 461683391 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51356998 COc1ccc(cc1)-c1n[nH]c2C(=O)N(C(c12)c1ccccc1OC)c1ccc(cc1)-c1ccon1 50548728 CHEMBL4756345 P2X purinoceptor 3 Homo sapiens 376 ChEMBL 10.1016/j.bmcl.2020.127636 10.7270/Q2CZ3BS8 33132115 Tobinaga, H; Kameyama, T; Asahi, K; Horiguchi, T; Oohara, M; Taoda, Y; Hata, K; Hasegawa, T; Tada, Y; Kurihara, N; Kanda, Y; Yagi, S; Tomari, M; Tanaka, Y; Takahashi, F; Taniguchi, E; Takahara, Y; Shimada, S; Takeyama, C; Yamamoto, S; Shinohara, S; Kai, H Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548728 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548728&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58045202 461679068 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51356999 CC(C)(C)c1n[nH]c2C(=O)N(C(C3CCCCC3)c12)c1ccc(cc1)-c1ccon1 50548729 CHEMBL4757664 P2X purinoceptor 3 Homo sapiens 916 ChEMBL 10.1016/j.bmcl.2020.127636 10.7270/Q2CZ3BS8 33132115 Tobinaga, H; Kameyama, T; Asahi, K; Horiguchi, T; Oohara, M; Taoda, Y; Hata, K; Hasegawa, T; Tada, Y; Kurihara, N; Kanda, Y; Yagi, S; Tomari, M; Tanaka, Y; Takahashi, F; Taniguchi, E; Takahara, Y; Shimada, S; Takeyama, C; Yamamoto, S; Shinohara, S; Kai, H Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548729 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548729&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 24970326 461679069 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51357000 COc1ccc(cc1)-c1c2C(C3CCCCC3)N(C(=O)c2nn1C)c1ccc(cc1)-c1ccon1 InChI=1S/C28H28N4O3/c1-31-26(20-10-14-22(34-2)15-11-20)24-25(29-31)28(33)32(27(24)19-6-4-3-5-7-19)21-12-8-18(9-13-21)23-16-17-35-30-23/h8-17,19,27H,3-7H2,1-2H3 IDXTUXLRJJOLHC-UHFFFAOYSA-N 50548730 CHEMBL4779710 P2X purinoceptor 3 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2020.127636 10.7270/Q2CZ3BS8 33132115 Tobinaga, H; Kameyama, T; Asahi, K; Horiguchi, T; Oohara, M; Taoda, Y; Hata, K; Hasegawa, T; Tada, Y; Kurihara, N; Kanda, Y; Yagi, S; Tomari, M; Tanaka, Y; Takahashi, F; Taniguchi, E; Takahara, Y; Shimada, S; Takeyama, C; Yamamoto, S; Shinohara, S; Kai, H Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548730 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548730&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 162663814 461679070 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51357001 CC(C)(C)c1n[nH]c2C(=O)N(C(c12)c1ccc(Cl)cc1)c1ccc(cc1)-c1ccon1 50548731 CHEMBL4748842 P2X purinoceptor 3 Homo sapiens 633 ChEMBL 10.1016/j.bmcl.2020.127636 10.7270/Q2CZ3BS8 33132115 Tobinaga, H; Kameyama, T; Asahi, K; Horiguchi, T; Oohara, M; Taoda, Y; Hata, K; Hasegawa, T; Tada, Y; Kurihara, N; Kanda, Y; Yagi, S; Tomari, M; Tanaka, Y; Takahashi, F; Taniguchi, E; Takahara, Y; Shimada, S; Takeyama, C; Yamamoto, S; Shinohara, S; Kai, H Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548731 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548731&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58045175 461679071 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51357002 CC(C)(C)c1n[nH]c2C(=O)N(C(c12)c1cccc(Cl)c1)c1ccc(cc1)-c1ccon1 50548732 CHEMBL4776973 P2X purinoceptor 3 Homo sapiens 1680 ChEMBL 10.1016/j.bmcl.2020.127636 10.7270/Q2CZ3BS8 33132115 Tobinaga, H; Kameyama, T; Asahi, K; Horiguchi, T; Oohara, M; Taoda, Y; Hata, K; Hasegawa, T; Tada, Y; Kurihara, N; Kanda, Y; Yagi, S; Tomari, M; Tanaka, Y; Takahashi, F; Taniguchi, E; Takahara, Y; Shimada, S; Takeyama, C; Yamamoto, S; Shinohara, S; Kai, H Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548732 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548732&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58045124 461679072 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51357003 CC(C)(C)c1n[nH]c2C(=O)N(C(c12)c1ccccc1Cl)c1ccc(cc1)-c1ccon1 50548733 CHEMBL4795192 P2X purinoceptor 3 Homo sapiens 466 ChEMBL 10.1016/j.bmcl.2020.127636 10.7270/Q2CZ3BS8 33132115 Tobinaga, H; Kameyama, T; Asahi, K; Horiguchi, T; Oohara, M; Taoda, Y; Hata, K; Hasegawa, T; Tada, Y; Kurihara, N; Kanda, Y; Yagi, S; Tomari, M; Tanaka, Y; Takahashi, F; Taniguchi, E; Takahara, Y; Shimada, S; Takeyama, C; Yamamoto, S; Shinohara, S; Kai, H Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548733 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548733&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58045118 461679073 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51357004 COc1ccc(cc1)C1N(C(=O)c2[nH]nc(c12)C(C)(C)C)c1ccc(cc1)-c1ccon1 50548734 CHEMBL4795906 P2X purinoceptor 3 Homo sapiens 1590 ChEMBL 10.1016/j.bmcl.2020.127636 10.7270/Q2CZ3BS8 33132115 Tobinaga, H; Kameyama, T; Asahi, K; Horiguchi, T; Oohara, M; Taoda, Y; Hata, K; Hasegawa, T; Tada, Y; Kurihara, N; Kanda, Y; Yagi, S; Tomari, M; Tanaka, Y; Takahashi, F; Taniguchi, E; Takahara, Y; Shimada, S; Takeyama, C; Yamamoto, S; Shinohara, S; Kai, H Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548734 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548734&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58044891 461679074 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51357005 COc1cccc(c1)C1N(C(=O)c2[nH]nc(c12)C(C)(C)C)c1ccc(cc1)-c1ccon1 50548735 CHEMBL4744375 P2X purinoceptor 3 Homo sapiens 690 ChEMBL 10.1016/j.bmcl.2020.127636 10.7270/Q2CZ3BS8 33132115 Tobinaga, H; Kameyama, T; Asahi, K; Horiguchi, T; Oohara, M; Taoda, Y; Hata, K; Hasegawa, T; Tada, Y; Kurihara, N; Kanda, Y; Yagi, S; Tomari, M; Tanaka, Y; Takahashi, F; Taniguchi, E; Takahara, Y; Shimada, S; Takeyama, C; Yamamoto, S; Shinohara, S; Kai, H Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548735 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548735&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58045031 461679075 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51357006 CC(C)(C)c1n[nH]c2C(=O)N(C(c12)c1ccccc1)c1ccc(cc1)-c1ccon1 50548736 CHEMBL4764172 P2X purinoceptor 3 Homo sapiens 304 ChEMBL 10.1016/j.bmcl.2020.127636 10.7270/Q2CZ3BS8 33132115 Tobinaga, H; Kameyama, T; Asahi, K; Horiguchi, T; Oohara, M; Taoda, Y; Hata, K; Hasegawa, T; Tada, Y; Kurihara, N; Kanda, Y; Yagi, S; Tomari, M; Tanaka, Y; Takahashi, F; Taniguchi, E; Takahara, Y; Shimada, S; Takeyama, C; Yamamoto, S; Shinohara, S; Kai, H Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548736 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548736&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58044908 461679076 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51357007 COc1ccccc1C1N(C(=O)c2[nH]nc(c12)C(C)(C)C)c1ccc(cc1)-c1ccon1 50548737 CHEMBL4765176 P2X purinoceptor 3 Homo sapiens 25 ChEMBL 10.1016/j.bmcl.2020.127636 10.7270/Q2CZ3BS8 33132115 Tobinaga, H; Kameyama, T; Asahi, K; Horiguchi, T; Oohara, M; Taoda, Y; Hata, K; Hasegawa, T; Tada, Y; Kurihara, N; Kanda, Y; Yagi, S; Tomari, M; Tanaka, Y; Takahashi, F; Taniguchi, E; Takahara, Y; Shimada, S; Takeyama, C; Yamamoto, S; Shinohara, S; Kai, H Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548737 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548737&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58045132 461679077 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51357008 COc1ccc(cc1)-c1nn(C)c2C(=O)N(C(C3CCCCC3)c12)c1ccc(cc1)-c1ccon1 InChI=1S/C28H28N4O3/c1-31-27-24(25(29-31)19-10-14-22(34-2)15-11-19)26(20-6-4-3-5-7-20)32(28(27)33)21-12-8-18(9-13-21)23-16-17-35-30-23/h8-17,20,26H,3-7H2,1-2H3 UGOXMOZNMBXYGP-UHFFFAOYSA-N 50548738 CHEMBL4785472 P2X purinoceptor 3 Homo sapiens 1560 ChEMBL 10.1016/j.bmcl.2020.127636 10.7270/Q2CZ3BS8 33132115 Tobinaga, H; Kameyama, T; Asahi, K; Horiguchi, T; Oohara, M; Taoda, Y; Hata, K; Hasegawa, T; Tada, Y; Kurihara, N; Kanda, Y; Yagi, S; Tomari, M; Tanaka, Y; Takahashi, F; Taniguchi, E; Takahara, Y; Shimada, S; Takeyama, C; Yamamoto, S; Shinohara, S; Kai, H Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548738 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548738&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58045044 461679078 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51357009 COc1ccc(cc1)-c1n[nH]c2C(=O)N(C(C3CCCCC3)c12)c1ccc(cc1)-c1ccon1 50548739 CHEMBL4750102 P2X purinoceptor 3 Homo sapiens 211 ChEMBL 10.1016/j.bmcl.2020.127636 10.7270/Q2CZ3BS8 33132115 Tobinaga, H; Kameyama, T; Asahi, K; Horiguchi, T; Oohara, M; Taoda, Y; Hata, K; Hasegawa, T; Tada, Y; Kurihara, N; Kanda, Y; Yagi, S; Tomari, M; Tanaka, Y; Takahashi, F; Taniguchi, E; Takahara, Y; Shimada, S; Takeyama, C; Yamamoto, S; Shinohara, S; Kai, H Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548739 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548739&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58045224 461679079 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51357010 CCc1ccccc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)C)c1ccc(cc1)-c1ccon1 InChI=1S/C26H26N4O2/c1-5-16-8-6-7-9-19(16)23-21-22(27-28-24(21)26(2,3)4)25(31)30(23)18-12-10-17(11-13-18)20-14-15-32-29-20/h6-15,23H,5H2,1-4H3,(H,27,28) WTWTVBWYWPXEPN-UHFFFAOYSA-N 106193 US8575197, II-106 P2X purinoceptor 3 Homo sapiens 226 ChEMBL 10.1016/j.bmcl.2020.127636 10.7270/Q2CZ3BS8 33132115 Tobinaga, H; Kameyama, T; Asahi, K; Horiguchi, T; Oohara, M; Taoda, Y; Hata, K; Hasegawa, T; Tada, Y; Kurihara, N; Kanda, Y; Yagi, S; Tomari, M; Tanaka, Y; Takahashi, F; Taniguchi, E; Takahara, Y; Shimada, S; Takeyama, C; Yamamoto, S; Shinohara, S; Kai, H Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106193 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106193&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58366031 174008504 ZINC96177114 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51357011 COc1ccccc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)C)c1ccc(cc1)-c1ccsc1 InChI=1S/C26H25N3O2S/c1-26(2,3)24-21-22(27-28-24)25(30)29(23(21)19-7-5-6-8-20(19)31-4)18-11-9-16(10-12-18)17-13-14-32-15-17/h5-15,23H,1-4H3,(H,27,28) IJIRNLYMFCQLQL-UHFFFAOYSA-N 106291 US8575197, II-204 P2X purinoceptor 3 Homo sapiens 17 ChEMBL 10.1016/j.bmcl.2020.127636 10.7270/Q2CZ3BS8 33132115 Tobinaga, H; Kameyama, T; Asahi, K; Horiguchi, T; Oohara, M; Taoda, Y; Hata, K; Hasegawa, T; Tada, Y; Kurihara, N; Kanda, Y; Yagi, S; Tomari, M; Tanaka, Y; Takahashi, F; Taniguchi, E; Takahara, Y; Shimada, S; Takeyama, C; Yamamoto, S; Shinohara, S; Kai, H Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106291 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106291&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365787 174008602 ZINC96177212 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51357012 COc1ccccc1C1N(C(=O)c2[nH]nc(c12)C(C)(C)C)c1ccc(cc1)-c1nccs1 50548740 CHEMBL4799974 P2X purinoceptor 3 Homo sapiens 25 ChEMBL 10.1016/j.bmcl.2020.127636 10.7270/Q2CZ3BS8 33132115 Tobinaga, H; Kameyama, T; Asahi, K; Horiguchi, T; Oohara, M; Taoda, Y; Hata, K; Hasegawa, T; Tada, Y; Kurihara, N; Kanda, Y; Yagi, S; Tomari, M; Tanaka, Y; Takahashi, F; Taniguchi, E; Takahara, Y; Shimada, S; Takeyama, C; Yamamoto, S; Shinohara, S; Kai, H Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548740 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548740&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58045072 461679080 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51357013 COc1ccccc1C1N(C(=O)c2[nH]nc(c12)C(C)(C)C)c1ccc(cc1)-c1nnc(C)o1 50548741 CHEMBL4762641 P2X purinoceptor 3 Homo sapiens 417 ChEMBL 10.1016/j.bmcl.2020.127636 10.7270/Q2CZ3BS8 33132115 Tobinaga, H; Kameyama, T; Asahi, K; Horiguchi, T; Oohara, M; Taoda, Y; Hata, K; Hasegawa, T; Tada, Y; Kurihara, N; Kanda, Y; Yagi, S; Tomari, M; Tanaka, Y; Takahashi, F; Taniguchi, E; Takahara, Y; Shimada, S; Takeyama, C; Yamamoto, S; Shinohara, S; Kai, H Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548741 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548741&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58045045 461679081 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51357014 COc1ccccc1C1N(C(=O)c2[nH]nc(c12)C(C)(C)C)c1ccc(cc1)-c1nc(C)no1 50548742 CHEMBL4745262 P2X purinoceptor 3 Homo sapiens 95 ChEMBL 10.1016/j.bmcl.2020.127636 10.7270/Q2CZ3BS8 33132115 Tobinaga, H; Kameyama, T; Asahi, K; Horiguchi, T; Oohara, M; Taoda, Y; Hata, K; Hasegawa, T; Tada, Y; Kurihara, N; Kanda, Y; Yagi, S; Tomari, M; Tanaka, Y; Takahashi, F; Taniguchi, E; Takahara, Y; Shimada, S; Takeyama, C; Yamamoto, S; Shinohara, S; Kai, H Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548742 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548742&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58044921 461679082 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51357015 COc1ccccc1C1N(C(=O)c2[nH]nc(c12)C(C)(C)C)c1ccc(cc1)-c1noc(C)n1 50548743 CHEMBL4745598 P2X purinoceptor 3 Homo sapiens 26 ChEMBL 10.1016/j.bmcl.2020.127636 10.7270/Q2CZ3BS8 33132115 Tobinaga, H; Kameyama, T; Asahi, K; Horiguchi, T; Oohara, M; Taoda, Y; Hata, K; Hasegawa, T; Tada, Y; Kurihara, N; Kanda, Y; Yagi, S; Tomari, M; Tanaka, Y; Takahashi, F; Taniguchi, E; Takahara, Y; Shimada, S; Takeyama, C; Yamamoto, S; Shinohara, S; Kai, H Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548743 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548743&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58045022 461679083 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51357016 COc1ccccc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)C)c1ccc(cc1)-c1ncco1 InChI=1S/C25H24N4O3/c1-25(2,3)22-19-20(27-28-22)24(30)29(21(19)17-7-5-6-8-18(17)31-4)16-11-9-15(10-12-16)23-26-13-14-32-23/h5-14,21H,1-4H3,(H,27,28) LWHAQVIKMODEMM-UHFFFAOYSA-N 106296 US8575197, II-209 P2X purinoceptor 3 Homo sapiens 87 ChEMBL 10.1016/j.bmcl.2020.127636 10.7270/Q2CZ3BS8 33132115 Tobinaga, H; Kameyama, T; Asahi, K; Horiguchi, T; Oohara, M; Taoda, Y; Hata, K; Hasegawa, T; Tada, Y; Kurihara, N; Kanda, Y; Yagi, S; Tomari, M; Tanaka, Y; Takahashi, F; Taniguchi, E; Takahara, Y; Shimada, S; Takeyama, C; Yamamoto, S; Shinohara, S; Kai, H Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106296 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106296&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58366024 174008607 ZINC96177216 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51357017 COc1ccccc1C1N(C(=O)c2[nH]nc(c12)C(C)(C)C)c1ccc(cc1)-c1cc(C)no1 50548744 CHEMBL4750518 P2X purinoceptor 3 Homo sapiens 72 ChEMBL 10.1016/j.bmcl.2020.127636 10.7270/Q2CZ3BS8 33132115 Tobinaga, H; Kameyama, T; Asahi, K; Horiguchi, T; Oohara, M; Taoda, Y; Hata, K; Hasegawa, T; Tada, Y; Kurihara, N; Kanda, Y; Yagi, S; Tomari, M; Tanaka, Y; Takahashi, F; Taniguchi, E; Takahara, Y; Shimada, S; Takeyama, C; Yamamoto, S; Shinohara, S; Kai, H Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548744 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548744&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58045325 461679084 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51357018 COc1ccccc1C1N(C(=O)c2[nH]nc(c12)C(C)(C)C)c1ccc(cc1)C(=O)N(C)C 50548745 CHEMBL4743161 P2X purinoceptor 3 Homo sapiens 1260 ChEMBL 10.1016/j.bmcl.2020.127636 10.7270/Q2CZ3BS8 33132115 Tobinaga, H; Kameyama, T; Asahi, K; Horiguchi, T; Oohara, M; Taoda, Y; Hata, K; Hasegawa, T; Tada, Y; Kurihara, N; Kanda, Y; Yagi, S; Tomari, M; Tanaka, Y; Takahashi, F; Taniguchi, E; Takahara, Y; Shimada, S; Takeyama, C; Yamamoto, S; Shinohara, S; Kai, H Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548745 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548745&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365234 461679085 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51357019 CNC(=O)c1ccc(cc1)N1C(c2c(n[nH]c2C1=O)C(C)(C)C)c1ccccc1OC 50548746 CHEMBL4793688 P2X purinoceptor 3 Homo sapiens 1336 ChEMBL 10.1016/j.bmcl.2020.127636 10.7270/Q2CZ3BS8 33132115 Tobinaga, H; Kameyama, T; Asahi, K; Horiguchi, T; Oohara, M; Taoda, Y; Hata, K; Hasegawa, T; Tada, Y; Kurihara, N; Kanda, Y; Yagi, S; Tomari, M; Tanaka, Y; Takahashi, F; Taniguchi, E; Takahara, Y; Shimada, S; Takeyama, C; Yamamoto, S; Shinohara, S; Kai, H Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548746 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548746&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365600 461679086 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51357020 CCOC(=O)c1ccc(cc1)N1C(c2c(n[nH]c2C(C)(C)C)C1=O)c1ccccc1OC InChI=1S/C25H27N3O4/c1-6-32-24(30)15-11-13-16(14-12-15)28-21(17-9-7-8-10-18(17)31-5)19-20(23(28)29)26-27-22(19)25(2,3)4/h7-14,21H,6H2,1-5H3,(H,26,27) ZQIRBVQPHGRYRK-UHFFFAOYSA-N 106144 US8575197, II-057 P2X purinoceptor 3 Homo sapiens 17 ChEMBL 10.1016/j.bmcl.2020.127636 10.7270/Q2CZ3BS8 33132115 Tobinaga, H; Kameyama, T; Asahi, K; Horiguchi, T; Oohara, M; Taoda, Y; Hata, K; Hasegawa, T; Tada, Y; Kurihara, N; Kanda, Y; Yagi, S; Tomari, M; Tanaka, Y; Takahashi, F; Taniguchi, E; Takahara, Y; Shimada, S; Takeyama, C; Yamamoto, S; Shinohara, S; Kai, H Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106144 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106144&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365762 174008455 ZINC96177065 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51357021 COc1ccccc1C1N(C(=O)c2[nH]nc(c12)C(C)(C)C)c1ccc(F)cc1 50548747 CHEMBL4745595 P2X purinoceptor 3 Homo sapiens 9300 ChEMBL 10.1016/j.bmcl.2020.127636 10.7270/Q2CZ3BS8 33132115 Tobinaga, H; Kameyama, T; Asahi, K; Horiguchi, T; Oohara, M; Taoda, Y; Hata, K; Hasegawa, T; Tada, Y; Kurihara, N; Kanda, Y; Yagi, S; Tomari, M; Tanaka, Y; Takahashi, F; Taniguchi, E; Takahara, Y; Shimada, S; Takeyama, C; Yamamoto, S; Shinohara, S; Kai, H Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548747 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548747&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58045098 461679087 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51357022 COc1ccccc1C1N(C(=O)c2[nH]nc(c12)-c1cccnc1)c1ccc(cc1)-c1ccon1 50548748 CHEMBL4764689 P2X purinoceptor 3 Homo sapiens 665 ChEMBL 10.1016/j.bmcl.2020.127636 10.7270/Q2CZ3BS8 33132115 Tobinaga, H; Kameyama, T; Asahi, K; Horiguchi, T; Oohara, M; Taoda, Y; Hata, K; Hasegawa, T; Tada, Y; Kurihara, N; Kanda, Y; Yagi, S; Tomari, M; Tanaka, Y; Takahashi, F; Taniguchi, E; Takahara, Y; Shimada, S; Takeyama, C; Yamamoto, S; Shinohara, S; Kai, H Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548748 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548748&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58045088 461679088 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51357023 COc1ccccc1C1N(C(=O)c2[nH]nc(-c3ccco3)c12)c1ccc(cc1)-c1ccon1 50548749 CHEMBL4779339 P2X purinoceptor 3 Homo sapiens 360 ChEMBL 10.1016/j.bmcl.2020.127636 10.7270/Q2CZ3BS8 33132115 Tobinaga, H; Kameyama, T; Asahi, K; Horiguchi, T; Oohara, M; Taoda, Y; Hata, K; Hasegawa, T; Tada, Y; Kurihara, N; Kanda, Y; Yagi, S; Tomari, M; Tanaka, Y; Takahashi, F; Taniguchi, E; Takahara, Y; Shimada, S; Takeyama, C; Yamamoto, S; Shinohara, S; Kai, H Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548749 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548749&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58045247 461679089 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51357024 COc1ccccc1C1N(C(=O)c2[nH]nc(C)c12)c1ccc(cc1)-c1ccon1 50548750 CHEMBL4744952 P2X purinoceptor 3 Homo sapiens 1633 ChEMBL 10.1016/j.bmcl.2020.127636 10.7270/Q2CZ3BS8 33132115 Tobinaga, H; Kameyama, T; Asahi, K; Horiguchi, T; Oohara, M; Taoda, Y; Hata, K; Hasegawa, T; Tada, Y; Kurihara, N; Kanda, Y; Yagi, S; Tomari, M; Tanaka, Y; Takahashi, F; Taniguchi, E; Takahara, Y; Shimada, S; Takeyama, C; Yamamoto, S; Shinohara, S; Kai, H Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548750 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548750&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58045103 461679090 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51357025 COc1ccccc1C1N(C(=O)c2[nH]nc(C(C)C)c12)c1ccc(cc1)-c1ccon1 50548751 CHEMBL4756303 P2X purinoceptor 3 Homo sapiens 112 ChEMBL 10.1016/j.bmcl.2020.127636 10.7270/Q2CZ3BS8 33132115 Tobinaga, H; Kameyama, T; Asahi, K; Horiguchi, T; Oohara, M; Taoda, Y; Hata, K; Hasegawa, T; Tada, Y; Kurihara, N; Kanda, Y; Yagi, S; Tomari, M; Tanaka, Y; Takahashi, F; Taniguchi, E; Takahara, Y; Shimada, S; Takeyama, C; Yamamoto, S; Shinohara, S; Kai, H Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548751 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548751&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 59447789 461679091 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51357026 CCCCc1n[nH]c2C(=O)N(C(c12)c1ccccc1OC)c1ccc(cc1)-c1ccon1 50548752 CHEMBL4744004 P2X purinoceptor 3 Homo sapiens 21 ChEMBL 10.1016/j.bmcl.2020.127636 10.7270/Q2CZ3BS8 33132115 Tobinaga, H; Kameyama, T; Asahi, K; Horiguchi, T; Oohara, M; Taoda, Y; Hata, K; Hasegawa, T; Tada, Y; Kurihara, N; Kanda, Y; Yagi, S; Tomari, M; Tanaka, Y; Takahashi, F; Taniguchi, E; Takahara, Y; Shimada, S; Takeyama, C; Yamamoto, S; Shinohara, S; Kai, H Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548752 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548752&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58044957 461679092 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51357027 COc1ccccc1C1N(C(=O)c2n[nH]c(CC(C)(C)C)c12)c1ccc(cc1)-c1ccon1 InChI=1S/C26H26N4O3/c1-26(2,3)15-20-22-23(28-27-20)25(31)30(24(22)18-7-5-6-8-21(18)32-4)17-11-9-16(10-12-17)19-13-14-33-29-19/h5-14,24H,15H2,1-4H3,(H,27,28) WWDHYUSDBHRABX-UHFFFAOYSA-N 106160 US8575197, II-073 P2X purinoceptor 3 Homo sapiens 105 ChEMBL 10.1016/j.bmcl.2020.127636 10.7270/Q2CZ3BS8 33132115 Tobinaga, H; Kameyama, T; Asahi, K; Horiguchi, T; Oohara, M; Taoda, Y; Hata, K; Hasegawa, T; Tada, Y; Kurihara, N; Kanda, Y; Yagi, S; Tomari, M; Tanaka, Y; Takahashi, F; Taniguchi, E; Takahara, Y; Shimada, S; Takeyama, C; Yamamoto, S; Shinohara, S; Kai, H Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106160 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106160&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58366149 174008471 ZINC96177081 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51357028 COc1cccc(OC)c1C1N(C(=O)c2n[nH]c(c12)C(C)(C)C)c1ccc(cc1)-c1ccon1 InChI=1S/C26H26N4O4/c1-26(2,3)24-21-22(27-28-24)25(31)30(16-11-9-15(10-12-16)17-13-14-34-29-17)23(21)20-18(32-4)7-6-8-19(20)33-5/h6-14,23H,1-5H3,(H,27,28) WCCXFFLJPHNRDB-UHFFFAOYSA-N 106147 US8575197, II-060 P2X purinoceptor 3 Homo sapiens 538 ChEMBL 10.1016/j.bmcl.2020.127636 10.7270/Q2CZ3BS8 33132115 Tobinaga, H; Kameyama, T; Asahi, K; Horiguchi, T; Oohara, M; Taoda, Y; Hata, K; Hasegawa, T; Tada, Y; Kurihara, N; Kanda, Y; Yagi, S; Tomari, M; Tanaka, Y; Takahashi, F; Taniguchi, E; Takahara, Y; Shimada, S; Takeyama, C; Yamamoto, S; Shinohara, S; Kai, H Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106147 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106147&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365443 174008458 ZINC96177068 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51357029 COc1cccc(C2N(C(=O)c3[nH]nc(c23)C(C)(C)C)c2ccc(cc2)-c2ccon2)c1OC 50548753 CHEMBL4795497 P2X purinoceptor 3 Homo sapiens 1690 ChEMBL 10.1016/j.bmcl.2020.127636 10.7270/Q2CZ3BS8 33132115 Tobinaga, H; Kameyama, T; Asahi, K; Horiguchi, T; Oohara, M; Taoda, Y; Hata, K; Hasegawa, T; Tada, Y; Kurihara, N; Kanda, Y; Yagi, S; Tomari, M; Tanaka, Y; Takahashi, F; Taniguchi, E; Takahara, Y; Shimada, S; Takeyama, C; Yamamoto, S; Shinohara, S; Kai, H Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548753 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548753&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365299 461679093 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51357030 CN(C)c1ccccc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)C)c1ccc(cc1)-c1ccon1 InChI=1S/C26H27N5O2/c1-26(2,3)24-21-22(27-28-24)25(32)31(23(21)18-8-6-7-9-20(18)30(4)5)17-12-10-16(11-13-17)19-14-15-33-29-19/h6-15,23H,1-5H3,(H,27,28) IUILRNVCPMSUEG-UHFFFAOYSA-N 106206 US8575197, II-119 P2X purinoceptor 3 Homo sapiens 137 ChEMBL 10.1016/j.bmcl.2020.127636 10.7270/Q2CZ3BS8 33132115 Tobinaga, H; Kameyama, T; Asahi, K; Horiguchi, T; Oohara, M; Taoda, Y; Hata, K; Hasegawa, T; Tada, Y; Kurihara, N; Kanda, Y; Yagi, S; Tomari, M; Tanaka, Y; Takahashi, F; Taniguchi, E; Takahara, Y; Shimada, S; Takeyama, C; Yamamoto, S; Shinohara, S; Kai, H Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106206 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106206&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365494 174008517 ZINC96177127 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51357031 CCOc1ccccc1C1N(C(=O)c2n[nH]c(c12)C(C)(C)C)c1ccc(cc1)-c1ccon1 InChI=1S/C26H26N4O3/c1-5-32-20-9-7-6-8-18(20)23-21-22(27-28-24(21)26(2,3)4)25(31)30(23)17-12-10-16(11-13-17)19-14-15-33-29-19/h6-15,23H,5H2,1-4H3,(H,27,28) UFOSBJIKHIBKKU-UHFFFAOYSA-N 106188 US8575197, II-101 P2X purinoceptor 3 Homo sapiens 270 ChEMBL 10.1016/j.bmcl.2020.127636 10.7270/Q2CZ3BS8 33132115 Tobinaga, H; Kameyama, T; Asahi, K; Horiguchi, T; Oohara, M; Taoda, Y; Hata, K; Hasegawa, T; Tada, Y; Kurihara, N; Kanda, Y; Yagi, S; Tomari, M; Tanaka, Y; Takahashi, F; Taniguchi, E; Takahara, Y; Shimada, S; Takeyama, C; Yamamoto, S; Shinohara, S; Kai, H Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106188 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106188&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365290 174008499 ZINC96177109 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51357032 CC(C)(C)c1[nH]nc2C(=O)N(C(c12)c1ccccc1OCCO)c1ccc(cc1)-c1ccon1 InChI=1S/C26H26N4O4/c1-26(2,3)24-21-22(27-28-24)25(32)30(17-10-8-16(9-11-17)19-12-14-34-29-19)23(21)18-6-4-5-7-20(18)33-15-13-31/h4-12,14,23,31H,13,15H2,1-3H3,(H,27,28) KULIBONXHNHSRK-UHFFFAOYSA-N 106187 US8575197, II-100 P2X purinoceptor 3 Homo sapiens 31 ChEMBL 10.1016/j.bmcl.2020.127636 10.7270/Q2CZ3BS8 33132115 Tobinaga, H; Kameyama, T; Asahi, K; Horiguchi, T; Oohara, M; Taoda, Y; Hata, K; Hasegawa, T; Tada, Y; Kurihara, N; Kanda, Y; Yagi, S; Tomari, M; Tanaka, Y; Takahashi, F; Taniguchi, E; Takahara, Y; Shimada, S; Takeyama, C; Yamamoto, S; Shinohara, S; Kai, H Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106187 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106187&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365447 174008498 ZINC96177108 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51357033 CC(C)(C)c1n[nH]c2C(=O)N(C(c12)c1ccccc1OCCS(C)(=O)=O)c1ccc(cc1)-c1ccon1 50548754 CHEMBL4758458 P2X purinoceptor 3 Homo sapiens 101 ChEMBL 10.1016/j.bmcl.2020.127636 10.7270/Q2CZ3BS8 33132115 Tobinaga, H; Kameyama, T; Asahi, K; Horiguchi, T; Oohara, M; Taoda, Y; Hata, K; Hasegawa, T; Tada, Y; Kurihara, N; Kanda, Y; Yagi, S; Tomari, M; Tanaka, Y; Takahashi, F; Taniguchi, E; Takahara, Y; Shimada, S; Takeyama, C; Yamamoto, S; Shinohara, S; Kai, H Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548754 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548754&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 162657264 461679094 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51357034 CC(C)(C)c1[nH]nc2C(=O)N(C(c12)c1ccccc1OCC(O)=O)c1ccc(cc1)-c1ccon1 InChI=1S/C26H24N4O5/c1-26(2,3)24-21-22(27-28-24)25(33)30(16-10-8-15(9-11-16)18-12-13-35-29-18)23(21)17-6-4-5-7-19(17)34-14-20(31)32/h4-13,23H,14H2,1-3H3,(H,27,28)(H,31,32) RPPBNXPYURTLBF-UHFFFAOYSA-N 106116 US8575197, II-029 P2X purinoceptor 3 Homo sapiens 90 ChEMBL 10.1016/j.bmcl.2020.127636 10.7270/Q2CZ3BS8 33132115 Tobinaga, H; Kameyama, T; Asahi, K; Horiguchi, T; Oohara, M; Taoda, Y; Hata, K; Hasegawa, T; Tada, Y; Kurihara, N; Kanda, Y; Yagi, S; Tomari, M; Tanaka, Y; Takahashi, F; Taniguchi, E; Takahara, Y; Shimada, S; Takeyama, C; Yamamoto, S; Shinohara, S; Kai, H Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106116 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106116&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365453 174008427 ZINC96176977 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51357035 COc1ccccc1C1N(C(=O)c2[nH]nc(CCO)c12)c1ccc(cc1)-c1ccon1 50548755 CHEMBL4741951 P2X purinoceptor 3 Homo sapiens 660 ChEMBL 10.1016/j.bmcl.2020.127636 10.7270/Q2CZ3BS8 33132115 Tobinaga, H; Kameyama, T; Asahi, K; Horiguchi, T; Oohara, M; Taoda, Y; Hata, K; Hasegawa, T; Tada, Y; Kurihara, N; Kanda, Y; Yagi, S; Tomari, M; Tanaka, Y; Takahashi, F; Taniguchi, E; Takahara, Y; Shimada, S; Takeyama, C; Yamamoto, S; Shinohara, S; Kai, H Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548755 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548755&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58044953 461679095 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51357036 COc1ccccc1C1N(C(=O)c2[nH]nc(c12)C(C)(C)CO)c1ccc(cc1)-c1ccon1 50548756 CHEMBL4797432 P2X purinoceptor 3 Homo sapiens 63 ChEMBL 10.1016/j.bmcl.2020.127636 10.7270/Q2CZ3BS8 33132115 Tobinaga, H; Kameyama, T; Asahi, K; Horiguchi, T; Oohara, M; Taoda, Y; Hata, K; Hasegawa, T; Tada, Y; Kurihara, N; Kanda, Y; Yagi, S; Tomari, M; Tanaka, Y; Takahashi, F; Taniguchi, E; Takahara, Y; Shimada, S; Takeyama, C; Yamamoto, S; Shinohara, S; Kai, H Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548756 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548756&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 59447788 461679096 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51357037 COc1ccccc1C1N(C(=O)c2n[nH]c(c12)C(C)(CO)CO)c1ccc(cc1)-c1ccon1 InChI=1S/C25H24N4O5/c1-25(13-30,14-31)23-20-21(26-27-23)24(32)29(22(20)17-5-3-4-6-19(17)33-2)16-9-7-15(8-10-16)18-11-12-34-28-18/h3-12,22,30-31H,13-14H2,1-2H3,(H,26,27) JUOGKKFFOPMFTH-UHFFFAOYSA-N 106345 US8575197, II-258 P2X purinoceptor 3 Homo sapiens 304 ChEMBL 10.1016/j.bmcl.2020.127636 10.7270/Q2CZ3BS8 33132115 Tobinaga, H; Kameyama, T; Asahi, K; Horiguchi, T; Oohara, M; Taoda, Y; Hata, K; Hasegawa, T; Tada, Y; Kurihara, N; Kanda, Y; Yagi, S; Tomari, M; Tanaka, Y; Takahashi, F; Taniguchi, E; Takahara, Y; Shimada, S; Takeyama, C; Yamamoto, S; Shinohara, S; Kai, H Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106345 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106345&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58365765 174008656 ZINC96177265 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51436286 COc1ccc(Cn2c(Nc3cccc(c3)C(F)(F)F)nc(=O)n(CC=C)c2=O)cc1 InChI=1S/C21H19F3N4O3/c1-3-11-27-19(29)26-18(25-16-6-4-5-15(12-16)21(22,23)24)28(20(27)30)13-14-7-9-17(31-2)10-8-14/h3-10,12H,1,11,13H2,2H3,(H,25,26,29) YLCXWPPDJFECQI-UHFFFAOYSA-N 50563053 CHEMBL4749540 P2X purinoceptor 3 Homo sapiens 1200 ChEMBL 10.1016/j.bmcl.2021.128384 10.7270/Q2S46WTX 34587541 Kai, H; Horiguchi, T; Kameyma, T; Onodera, N; Itoh, N; Fujii, Y; Ichihashi, Y; Hirai, K; Shintani, T; Nakamura, K; Minami, K; Kasai, E; Yoneda, S; Murakami, Y; Ogawa, H; Sekimoto, R; Shinohara, S; Yoshida, O; Kurose, N Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50563053 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50563053&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578701 461683391 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51436287 CC(C)Oc1ccc(Nc2nc(=O)n(C(C)C)c(=O)n2Cc2ccc(Cl)cc2)cc1 InChI=1S/C22H25ClN4O3/c1-14(2)27-21(28)25-20(24-18-9-11-19(12-10-18)30-15(3)4)26(22(27)29)13-16-5-7-17(23)8-6-16/h5-12,14-15H,13H2,1-4H3,(H,24,25,28) KRYNINNUFDZTED-UHFFFAOYSA-N 183089 US9150546, I-200::US9688643, I-200::US9718790, I-0200 P2X purinoceptor 3 Homo sapiens 128 ChEMBL 10.1016/j.bmcl.2021.128384 10.7270/Q2S46WTX 34587541 Kai, H; Horiguchi, T; Kameyma, T; Onodera, N; Itoh, N; Fujii, Y; Ichihashi, Y; Hirai, K; Shintani, T; Nakamura, K; Minami, K; Kasai, E; Yoneda, S; Murakami, Y; Ogawa, H; Sekimoto, R; Shinohara, S; Yoshida, O; Kurose, N Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183089 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183089&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821207 313634489 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51436288 CC(C)Oc1ccc(Nc2nc(=O)n(CCC(O)=O)c(=O)n2Cc2ccc(C)cc2)cc1Cl InChI=1S/C23H25ClN4O5/c1-14(2)33-19-9-8-17(12-18(19)24)25-21-26-22(31)27(11-10-20(29)30)23(32)28(21)13-16-6-4-15(3)5-7-16/h4-9,12,14H,10-11,13H2,1-3H3,(H,29,30)(H,25,26,31) KRHNDEFYSFIWAD-UHFFFAOYSA-N 50563052 CHEMBL4748113 P2X purinoceptor 3 Homo sapiens 16 ChEMBL 10.1016/j.bmcl.2021.128384 10.7270/Q2S46WTX 34587541 Kai, H; Horiguchi, T; Kameyma, T; Onodera, N; Itoh, N; Fujii, Y; Ichihashi, Y; Hirai, K; Shintani, T; Nakamura, K; Minami, K; Kasai, E; Yoneda, S; Murakami, Y; Ogawa, H; Sekimoto, R; Shinohara, S; Yoshida, O; Kurose, N Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50563052 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50563052&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68020375 461683390 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51436289 CC(C)Oc1ccc(Nc2nc(=O)n(CCC(O)=O)c(=O)n2Cc2ccc(Cl)cc2)cc1Cl InChI=1S/C22H22Cl2N4O5/c1-13(2)33-18-8-7-16(11-17(18)24)25-20-26-21(31)27(10-9-19(29)30)22(32)28(20)12-14-3-5-15(23)6-4-14/h3-8,11,13H,9-10,12H2,1-2H3,(H,29,30)(H,25,26,31) LTHMPYWKRCESAL-UHFFFAOYSA-N 183191 US9150546, I-355::US9688643, I-355::US9718790, I-0355 P2X purinoceptor 3 Homo sapiens 20 ChEMBL 10.1016/j.bmcl.2021.128384 10.7270/Q2S46WTX 34587541 Kai, H; Horiguchi, T; Kameyma, T; Onodera, N; Itoh, N; Fujii, Y; Ichihashi, Y; Hirai, K; Shintani, T; Nakamura, K; Minami, K; Kasai, E; Yoneda, S; Murakami, Y; Ogawa, H; Sekimoto, R; Shinohara, S; Yoshida, O; Kurose, N Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183191 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183191&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821101 313634591 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51436290 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n1Cc1ccc(C)cc1 InChI=1S/C25H29ClN4O5/c1-15(2)35-20-11-10-18(12-19(20)26)27-22-28-23(33)30(14-25(4,5)21(31)32)24(34)29(22)13-17-8-6-16(3)7-9-17/h6-12,15H,13-14H2,1-5H3,(H,31,32)(H,27,28,33) IEFCYNPWRFXORF-UHFFFAOYSA-N 183238 US9150546, I-408::US9688643, I-408::US9718790, I-0407 P2X purinoceptor 3 Homo sapiens 9.8 ChEMBL 10.1016/j.bmcl.2021.128384 10.7270/Q2S46WTX 34587541 Kai, H; Horiguchi, T; Kameyma, T; Onodera, N; Itoh, N; Fujii, Y; Ichihashi, Y; Hirai, K; Shintani, T; Nakamura, K; Minami, K; Kasai, E; Yoneda, S; Murakami, Y; Ogawa, H; Sekimoto, R; Shinohara, S; Yoshida, O; Kurose, N Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183238 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183238&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578596 313634638 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51436291 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(CC(C)(C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C24H26Cl2N4O5/c1-14(2)35-19-10-9-17(11-18(19)26)27-21-28-22(33)30(13-24(3,4)20(31)32)23(34)29(21)12-15-5-7-16(25)8-6-15/h5-11,14H,12-13H2,1-4H3,(H,31,32)(H,27,28,33) JBUWYWPQCDLCBD-UHFFFAOYSA-N 183231 US9150546, I-401::US9688643, I-401::US9718790, I-0400 P2X purinoceptor 3 Homo sapiens 6.7 ChEMBL 10.1016/j.bmcl.2021.128384 10.7270/Q2S46WTX 34587541 Kai, H; Horiguchi, T; Kameyma, T; Onodera, N; Itoh, N; Fujii, Y; Ichihashi, Y; Hirai, K; Shintani, T; Nakamura, K; Minami, K; Kasai, E; Yoneda, S; Murakami, Y; Ogawa, H; Sekimoto, R; Shinohara, S; Yoshida, O; Kurose, N Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183231 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183231&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578683 313634631 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51436292 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(C[C@@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 183291 US9150546, I-460::US9688643, I-460::US9718790, I-0469 P2X purinoceptor 3 Homo sapiens 16 ChEMBL 10.1016/j.bmcl.2021.128384 10.7270/Q2S46WTX 34587541 Kai, H; Horiguchi, T; Kameyma, T; Onodera, N; Itoh, N; Fujii, Y; Ichihashi, Y; Hirai, K; Shintani, T; Nakamura, K; Minami, K; Kasai, E; Yoneda, S; Murakami, Y; Ogawa, H; Sekimoto, R; Shinohara, S; Yoshida, O; Kurose, N Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183291 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183291&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578529 313634691 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51436293 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 183292 US9150546, I-461::US9688643, I-461::US9718790, I-0470 P2X purinoceptor 3 Homo sapiens 9.0 ChEMBL 10.1016/j.bmcl.2021.128384 10.7270/Q2S46WTX 34587541 Kai, H; Horiguchi, T; Kameyma, T; Onodera, N; Itoh, N; Fujii, Y; Ichihashi, Y; Hirai, K; Shintani, T; Nakamura, K; Minami, K; Kasai, E; Yoneda, S; Murakami, Y; Ogawa, H; Sekimoto, R; Shinohara, S; Yoshida, O; Kurose, N Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183292 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183292&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578746 313634692 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51436294 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(C)cc1 183344 US9150546, I-518::US9688643, I-518::US9718790, I-0527 P2X purinoceptor 3 Homo sapiens 7.0 ChEMBL 10.1016/j.bmcl.2021.128384 10.7270/Q2S46WTX 34587541 Kai, H; Horiguchi, T; Kameyma, T; Onodera, N; Itoh, N; Fujii, Y; Ichihashi, Y; Hirai, K; Shintani, T; Nakamura, K; Minami, K; Kasai, E; Yoneda, S; Murakami, Y; Ogawa, H; Sekimoto, R; Shinohara, S; Yoshida, O; Kurose, N Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183344 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183344&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578621 313634744 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51436295 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(CCCC(O)=O)c(=O)n1Cc1ccc(C)cc1 InChI=1S/C24H27ClN4O5/c1-15(2)34-20-11-10-18(13-19(20)25)26-22-27-23(32)28(12-4-5-21(30)31)24(33)29(22)14-17-8-6-16(3)7-9-17/h6-11,13,15H,4-5,12,14H2,1-3H3,(H,30,31)(H,26,27,32) NXLSNMXBBXKVGK-UHFFFAOYSA-N 183345 US9150546, I-519::US9688643, I-519::US9718790, I-0528 P2X purinoceptor 3 Homo sapiens 12 ChEMBL 10.1016/j.bmcl.2021.128384 10.7270/Q2S46WTX 34587541 Kai, H; Horiguchi, T; Kameyma, T; Onodera, N; Itoh, N; Fujii, Y; Ichihashi, Y; Hirai, K; Shintani, T; Nakamura, K; Minami, K; Kasai, E; Yoneda, S; Murakami, Y; Ogawa, H; Sekimoto, R; Shinohara, S; Yoshida, O; Kurose, N Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183345 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183345&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578649 313634745 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51436296 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(CCCC(O)=O)c(=O)n1Cc1ccc(Cl)cc1 InChI=1S/C23H24Cl2N4O5/c1-14(2)34-19-10-9-17(12-18(19)25)26-21-27-22(32)28(11-3-4-20(30)31)23(33)29(21)13-15-5-7-16(24)8-6-15/h5-10,12,14H,3-4,11,13H2,1-2H3,(H,30,31)(H,26,27,32) WCZMIXQUMLQDCK-UHFFFAOYSA-N 183330 US9150546, I-500::US9688643, I-500::US9718790, I-0509 P2X purinoceptor 3 Homo sapiens 13 ChEMBL 10.1016/j.bmcl.2021.128384 10.7270/Q2S46WTX 34587541 Kai, H; Horiguchi, T; Kameyma, T; Onodera, N; Itoh, N; Fujii, Y; Ichihashi, Y; Hirai, K; Shintani, T; Nakamura, K; Minami, K; Kasai, E; Yoneda, S; Murakami, Y; Ogawa, H; Sekimoto, R; Shinohara, S; Yoshida, O; Kurose, N Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183330 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183330&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578791 313634730 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51436297 CC(C)Oc1ccc(Nc2nc(=O)n(CCO)c(=O)n2Cc2ccc(Cl)cc2)cc1Cl InChI=1S/C21H22Cl2N4O4/c1-13(2)31-18-8-7-16(11-17(18)23)24-19-25-20(29)26(9-10-28)21(30)27(19)12-14-3-5-15(22)6-4-14/h3-8,11,13,28H,9-10,12H2,1-2H3,(H,24,25,29) LVLPRWHJRHKWQM-UHFFFAOYSA-N 183187 US9150546, I-351::US9688643, I-351::US9718790, I-0351 P2X purinoceptor 3 Homo sapiens 15 ChEMBL 10.1016/j.bmcl.2021.128384 10.7270/Q2S46WTX 34587541 Kai, H; Horiguchi, T; Kameyma, T; Onodera, N; Itoh, N; Fujii, Y; Ichihashi, Y; Hirai, K; Shintani, T; Nakamura, K; Minami, K; Kasai, E; Yoneda, S; Murakami, Y; Ogawa, H; Sekimoto, R; Shinohara, S; Yoshida, O; Kurose, N Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183187 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183187&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821305 313634587 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51436298 CC(C)Oc1ccc(Nc2nc(=O)n(CCCO)c(=O)n2Cc2ccc(Cl)cc2)cc1Cl InChI=1S/C22H24Cl2N4O4/c1-14(2)32-19-9-8-17(12-18(19)24)25-20-26-21(30)27(10-3-11-29)22(31)28(20)13-15-4-6-16(23)7-5-15/h4-9,12,14,29H,3,10-11,13H2,1-2H3,(H,25,26,30) CGVREEYRNJNDLQ-UHFFFAOYSA-N 183198 US9150546, I-362::US9688643, I-362::US9718790, I-0362 P2X purinoceptor 3 Homo sapiens 6.9 ChEMBL 10.1016/j.bmcl.2021.128384 10.7270/Q2S46WTX 34587541 Kai, H; Horiguchi, T; Kameyma, T; Onodera, N; Itoh, N; Fujii, Y; Ichihashi, Y; Hirai, K; Shintani, T; Nakamura, K; Minami, K; Kasai, E; Yoneda, S; Murakami, Y; Ogawa, H; Sekimoto, R; Shinohara, S; Yoshida, O; Kurose, N Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183198 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183198&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821189 313634598 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51436299 CC(C)Oc1ccc(Nc2nc(=O)n(CC(CO)CO)c(=O)n2Cc2ccc(Cl)cc2)cc1Cl InChI=1S/C23H26Cl2N4O5/c1-14(2)34-20-8-7-18(9-19(20)25)26-21-27-22(32)29(11-16(12-30)13-31)23(33)28(21)10-15-3-5-17(24)6-4-15/h3-9,14,16,30-31H,10-13H2,1-2H3,(H,26,27,32) PLKBMAZPUXNVOD-UHFFFAOYSA-N 183205 US9150546, I-369::US9688643, I-369::US9718790, I-0369 P2X purinoceptor 3 Homo sapiens 6.7 ChEMBL 10.1016/j.bmcl.2021.128384 10.7270/Q2S46WTX 34587541 Kai, H; Horiguchi, T; Kameyma, T; Onodera, N; Itoh, N; Fujii, Y; Ichihashi, Y; Hirai, K; Shintani, T; Nakamura, K; Minami, K; Kasai, E; Yoneda, S; Murakami, Y; Ogawa, H; Sekimoto, R; Shinohara, S; Yoshida, O; Kurose, N Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183205 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183205&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76821090 313634605 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51436300 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(C[C@H](O)CO)c(=O)n1Cc1ccc(Cl)cc1 265838 US9718790, I-0638 P2X purinoceptor 3 Homo sapiens 10 ChEMBL 10.1016/j.bmcl.2021.128384 10.7270/Q2S46WTX 34587541 Kai, H; Horiguchi, T; Kameyma, T; Onodera, N; Itoh, N; Fujii, Y; Ichihashi, Y; Hirai, K; Shintani, T; Nakamura, K; Minami, K; Kasai, E; Yoneda, S; Murakami, Y; Ogawa, H; Sekimoto, R; Shinohara, S; Yoshida, O; Kurose, N Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265838 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265838&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019522 377004710 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51436301 CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(C[C@@H](O)CO)c(=O)n1Cc1ccc(Cl)cc1 265772 US9718790, I-0616 P2X purinoceptor 3 Homo sapiens 5.7 ChEMBL 10.1016/j.bmcl.2021.128384 10.7270/Q2S46WTX 34587541 Kai, H; Horiguchi, T; Kameyma, T; Onodera, N; Itoh, N; Fujii, Y; Ichihashi, Y; Hirai, K; Shintani, T; Nakamura, K; Minami, K; Kasai, E; Yoneda, S; Murakami, Y; Ogawa, H; Sekimoto, R; Shinohara, S; Yoshida, O; Kurose, N Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265772 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265772&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 86689090 377004644 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51436302 CC(C)Oc1ccc(cc1F)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 183287 US9150546, I-456::US9688643, I-456::US9718790, I-0465 P2X purinoceptor 3 Homo sapiens 7.8 ChEMBL 10.1016/j.bmcl.2021.128384 10.7270/Q2S46WTX 34587541 Kai, H; Horiguchi, T; Kameyma, T; Onodera, N; Itoh, N; Fujii, Y; Ichihashi, Y; Hirai, K; Shintani, T; Nakamura, K; Minami, K; Kasai, E; Yoneda, S; Murakami, Y; Ogawa, H; Sekimoto, R; Shinohara, S; Yoshida, O; Kurose, N Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183287 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183287&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578933 313634687 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51436303 CC(C)Oc1ccc(cc1C)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 183364 US9150546, I-538::US9688643, I-538::US9718790, I-0547 P2X purinoceptor 3 Homo sapiens 16 ChEMBL 10.1016/j.bmcl.2021.128384 10.7270/Q2S46WTX 34587541 Kai, H; Horiguchi, T; Kameyma, T; Onodera, N; Itoh, N; Fujii, Y; Ichihashi, Y; Hirai, K; Shintani, T; Nakamura, K; Minami, K; Kasai, E; Yoneda, S; Murakami, Y; Ogawa, H; Sekimoto, R; Shinohara, S; Yoshida, O; Kurose, N Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183364 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183364&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578644 313634764 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51436304 CC(C)Oc1ccc(cc1)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 183363 US9150546, I-537::US9688643, I-537::US9718790, I-0546 P2X purinoceptor 3 Homo sapiens 19 ChEMBL 10.1016/j.bmcl.2021.128384 10.7270/Q2S46WTX 34587541 Kai, H; Horiguchi, T; Kameyma, T; Onodera, N; Itoh, N; Fujii, Y; Ichihashi, Y; Hirai, K; Shintani, T; Nakamura, K; Minami, K; Kasai, E; Yoneda, S; Murakami, Y; Ogawa, H; Sekimoto, R; Shinohara, S; Yoshida, O; Kurose, N Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183363 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183363&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 58578598 313634763 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51436305 CC(C)COc1ccc(cc1)\N=c1/[nH]c(=O)n(C[C@H](C)C(O)=O)c(=O)n1Cc1ccc(Cl)cc1 266159 US9718790, I-0750 P2X purinoceptor 3 Homo sapiens 22 ChEMBL 10.1016/j.bmcl.2021.128384 10.7270/Q2S46WTX 34587541 Kai, H; Horiguchi, T; Kameyma, T; Onodera, N; Itoh, N; Fujii, Y; Ichihashi, Y; Hirai, K; Shintani, T; Nakamura, K; Minami, K; Kasai, E; Yoneda, S; Murakami, Y; Ogawa, H; Sekimoto, R; Shinohara, S; Yoshida, O; Kurose, N Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266159 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266159&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019985 377005031 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51436306 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(OC3CCC3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 265821 US9718790, I-1284 P2X purinoceptor 3 Homo sapiens 15 ChEMBL 10.1016/j.bmcl.2021.128384 10.7270/Q2S46WTX 34587541 Kai, H; Horiguchi, T; Kameyma, T; Onodera, N; Itoh, N; Fujii, Y; Ichihashi, Y; Hirai, K; Shintani, T; Nakamura, K; Minami, K; Kasai, E; Yoneda, S; Murakami, Y; Ogawa, H; Sekimoto, R; Shinohara, S; Yoshida, O; Kurose, N Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265821 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265821&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 118945151 377004693 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51436307 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(OCC3CC3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 266400 US9718790, I-0837 P2X purinoceptor 3 Homo sapiens 17 ChEMBL 10.1016/j.bmcl.2021.128384 10.7270/Q2S46WTX 34587541 Kai, H; Horiguchi, T; Kameyma, T; Onodera, N; Itoh, N; Fujii, Y; Ichihashi, Y; Hirai, K; Shintani, T; Nakamura, K; Minami, K; Kasai, E; Yoneda, S; Murakami, Y; Ogawa, H; Sekimoto, R; Shinohara, S; Yoshida, O; Kurose, N Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=266400 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=266400&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019790 377005271 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51436308 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccc3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 265000 US9718790, I-0991 P2X purinoceptor 3 Homo sapiens 22 ChEMBL 10.1016/j.bmcl.2021.128384 10.7270/Q2S46WTX 34587541 Kai, H; Horiguchi, T; Kameyma, T; Onodera, N; Itoh, N; Fujii, Y; Ichihashi, Y; Hirai, K; Shintani, T; Nakamura, K; Minami, K; Kasai, E; Yoneda, S; Murakami, Y; Ogawa, H; Sekimoto, R; Shinohara, S; Yoshida, O; Kurose, N Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=265000 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=265000&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 68019804 377003876 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51436309 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ncco3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 50580218 CHEMBL5088459 P2X purinoceptor 3 Homo sapiens 31 ChEMBL 10.1016/j.bmcl.2021.128384 10.7270/Q2S46WTX 34587541 Kai, H; Horiguchi, T; Kameyma, T; Onodera, N; Itoh, N; Fujii, Y; Ichihashi, Y; Hirai, K; Shintani, T; Nakamura, K; Minami, K; Kasai, E; Yoneda, S; Murakami, Y; Ogawa, H; Sekimoto, R; Shinohara, S; Yoshida, O; Kurose, N Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50580218 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50580218&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 166634308 476025223 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51436310 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccon3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 50580219 CHEMBL5074869 P2X purinoceptor 3 Homo sapiens 17 ChEMBL 10.1016/j.bmcl.2021.128384 10.7270/Q2S46WTX 34587541 Kai, H; Horiguchi, T; Kameyma, T; Onodera, N; Itoh, N; Fujii, Y; Ichihashi, Y; Hirai, K; Shintani, T; Nakamura, K; Minami, K; Kasai, E; Yoneda, S; Murakami, Y; Ogawa, H; Sekimoto, R; Shinohara, S; Yoshida, O; Kurose, N Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50580219 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50580219&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 89640092 476025224 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51436311 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3nccs3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 50580220 CHEMBL5086991 P2X purinoceptor 3 Homo sapiens 6.3 ChEMBL 10.1016/j.bmcl.2021.128384 10.7270/Q2S46WTX 34587541 Kai, H; Horiguchi, T; Kameyma, T; Onodera, N; Itoh, N; Fujii, Y; Ichihashi, Y; Hirai, K; Shintani, T; Nakamura, K; Minami, K; Kasai, E; Yoneda, S; Murakami, Y; Ogawa, H; Sekimoto, R; Shinohara, S; Yoshida, O; Kurose, N Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50580220 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50580220&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 89640001 476025225 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51436312 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccsn3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 50580221 CHEMBL5073093 P2X purinoceptor 3 Homo sapiens 5.6 ChEMBL 10.1016/j.bmcl.2021.128384 10.7270/Q2S46WTX 34587541 Kai, H; Horiguchi, T; Kameyma, T; Onodera, N; Itoh, N; Fujii, Y; Ichihashi, Y; Hirai, K; Shintani, T; Nakamura, K; Minami, K; Kasai, E; Yoneda, S; Murakami, Y; Ogawa, H; Sekimoto, R; Shinohara, S; Yoshida, O; Kurose, N Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50580221 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50580221&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 166630603 476025226 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51436313 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271626 US10065941, Compound I-127::US9732060, Compound I-127 P2X purinoceptor 3 Homo sapiens 4.2 ChEMBL 10.1016/j.bmcl.2021.128384 10.7270/Q2S46WTX 34587541 Kai, H; Horiguchi, T; Kameyma, T; Onodera, N; Itoh, N; Fujii, Y; Ichihashi, Y; Hirai, K; Shintani, T; Nakamura, K; Minami, K; Kasai, E; Yoneda, S; Murakami, Y; Ogawa, H; Sekimoto, R; Shinohara, S; Yoshida, O; Kurose, N Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271626 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271626&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752163 378153454 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51436314 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cccnc3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271892 US10065941, Compound R-207::US9732060, Compound R-207 P2X purinoceptor 3 Homo sapiens 8.6 ChEMBL 10.1016/j.bmcl.2021.128384 10.7270/Q2S46WTX 34587541 Kai, H; Horiguchi, T; Kameyma, T; Onodera, N; Itoh, N; Fujii, Y; Ichihashi, Y; Hirai, K; Shintani, T; Nakamura, K; Minami, K; Kasai, E; Yoneda, S; Murakami, Y; Ogawa, H; Sekimoto, R; Shinohara, S; Yoshida, O; Kurose, N Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271892 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271892&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295640 378153718 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51436315 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccncc3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271893 US10065941, Compound R-208::US9732060, Compound R-208 P2X purinoceptor 3 Homo sapiens 5.2 ChEMBL 10.1016/j.bmcl.2021.128384 10.7270/Q2S46WTX 34587541 Kai, H; Horiguchi, T; Kameyma, T; Onodera, N; Itoh, N; Fujii, Y; Ichihashi, Y; Hirai, K; Shintani, T; Nakamura, K; Minami, K; Kasai, E; Yoneda, S; Murakami, Y; Ogawa, H; Sekimoto, R; Shinohara, S; Yoshida, O; Kurose, N Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271893 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271893&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295641 378153719 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51436316 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ncccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271767 US10065941, Compound R-078::US9732060, Compound R-078 P2X purinoceptor 3 Homo sapiens 9.9 ChEMBL 10.1016/j.bmcl.2021.128384 10.7270/Q2S46WTX 34587541 Kai, H; Horiguchi, T; Kameyma, T; Onodera, N; Itoh, N; Fujii, Y; Ichihashi, Y; Hirai, K; Shintani, T; Nakamura, K; Minami, K; Kasai, E; Yoneda, S; Murakami, Y; Ogawa, H; Sekimoto, R; Shinohara, S; Yoshida, O; Kurose, N Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271767 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271767&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295528 378153593 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51436317 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cnccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271685 US10065941, Compound R-019::US9732060, Compound R-019 P2X purinoceptor 3 Homo sapiens 5.8 ChEMBL 10.1016/j.bmcl.2021.128384 10.7270/Q2S46WTX 34587541 Kai, H; Horiguchi, T; Kameyma, T; Onodera, N; Itoh, N; Fujii, Y; Ichihashi, Y; Hirai, K; Shintani, T; Nakamura, K; Minami, K; Kasai, E; Yoneda, S; Murakami, Y; Ogawa, H; Sekimoto, R; Shinohara, S; Yoshida, O; Kurose, N Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271685 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271685&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295477 378153511 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51436318 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cccnn3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271805 US10065941, Compound R-120::US9732060, Compound R-120 P2X purinoceptor 3 Homo sapiens 7.7 ChEMBL 10.1016/j.bmcl.2021.128384 10.7270/Q2S46WTX 34587541 Kai, H; Horiguchi, T; Kameyma, T; Onodera, N; Itoh, N; Fujii, Y; Ichihashi, Y; Hirai, K; Shintani, T; Nakamura, K; Minami, K; Kasai, E; Yoneda, S; Murakami, Y; Ogawa, H; Sekimoto, R; Shinohara, S; Yoshida, O; Kurose, N Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271805 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271805&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121295556 378153631 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51436319 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cc(F)ccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271569 US10065941, Compound I-070::US9732060, Compound I-070 P2X purinoceptor 3 Homo sapiens 4.9 ChEMBL 10.1016/j.bmcl.2021.128384 10.7270/Q2S46WTX 34587541 Kai, H; Horiguchi, T; Kameyma, T; Onodera, N; Itoh, N; Fujii, Y; Ichihashi, Y; Hirai, K; Shintani, T; Nakamura, K; Minami, K; Kasai, E; Yoneda, S; Murakami, Y; Ogawa, H; Sekimoto, R; Shinohara, S; Yoshida, O; Kurose, N Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271569 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271569&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752201 378153397 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51436320 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(F)cn3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 50580222 CHEMBL5076078 P2X purinoceptor 3 Homo sapiens 3.1 ChEMBL 10.1016/j.bmcl.2021.128384 10.7270/Q2S46WTX 34587541 Kai, H; Horiguchi, T; Kameyma, T; Onodera, N; Itoh, N; Fujii, Y; Ichihashi, Y; Hirai, K; Shintani, T; Nakamura, K; Minami, K; Kasai, E; Yoneda, S; Murakami, Y; Ogawa, H; Sekimoto, R; Shinohara, S; Yoshida, O; Kurose, N Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50580222 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50580222&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 145593644 476025227 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51436321 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cccc(F)n3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 50580223 CHEMBL5079957 P2X purinoceptor 3 Homo sapiens 3.0 ChEMBL 10.1016/j.bmcl.2021.128384 10.7270/Q2S46WTX 34587541 Kai, H; Horiguchi, T; Kameyma, T; Onodera, N; Itoh, N; Fujii, Y; Ichihashi, Y; Hirai, K; Shintani, T; Nakamura, K; Minami, K; Kasai, E; Yoneda, S; Murakami, Y; Ogawa, H; Sekimoto, R; Shinohara, S; Yoshida, O; Kurose, N Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50580223 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50580223&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 89640134 476025228 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51436322 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cncc(F)c3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 50580224 CHEMBL5090841 P2X purinoceptor 3 Homo sapiens 5.6 ChEMBL 10.1016/j.bmcl.2021.128384 10.7270/Q2S46WTX 34587541 Kai, H; Horiguchi, T; Kameyma, T; Onodera, N; Itoh, N; Fujii, Y; Ichihashi, Y; Hirai, K; Shintani, T; Nakamura, K; Minami, K; Kasai, E; Yoneda, S; Murakami, Y; Ogawa, H; Sekimoto, R; Shinohara, S; Yoshida, O; Kurose, N Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50580224 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50580224&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 148259519 476025229 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51436323 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccnc(F)c3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 50580225 CHEMBL5084053 P2X purinoceptor 3 Homo sapiens 5.4 ChEMBL 10.1016/j.bmcl.2021.128384 10.7270/Q2S46WTX 34587541 Kai, H; Horiguchi, T; Kameyma, T; Onodera, N; Itoh, N; Fujii, Y; Ichihashi, Y; Hirai, K; Shintani, T; Nakamura, K; Minami, K; Kasai, E; Yoneda, S; Murakami, Y; Ogawa, H; Sekimoto, R; Shinohara, S; Yoshida, O; Kurose, N Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50580225 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50580225&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 89640043 476025230 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51467778 CNC(=O)c1cc(F)c(-c2nc3cc(C)ccc3n2CC2CCCNC2)c(F)c1 InChI=1S/C22H24F2N4O/c1-13-5-6-19-18(8-13)27-21(28(19)12-14-4-3-7-26-11-14)20-16(23)9-15(10-17(20)24)22(29)25-2/h5-6,8-10,14,26H,3-4,7,11-12H2,1-2H3,(H,25,29) LCDRECFEYCRYIZ-UHFFFAOYSA-N 50592267 CHEMBL5187981 P2X purinoceptor 3 Homo sapiens 331 ChEMBL 10.7270/Q2SX6J56 35644300 Bae, J; Kang, KM; Kim, YC Gwangju Institute of Science and Technology (GIST) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592267 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592267&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 168278686 482603119 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51467779 CNC(=O)c1cc(F)c(-c2nc3cc(C)ccc3n2CC2CCCN(C2)C(=O)OC)c(F)c1 InChI=1S/C24H26F2N4O3/c1-14-6-7-20-19(9-14)28-22(21-17(25)10-16(11-18(21)26)23(31)27-2)30(20)13-15-5-4-8-29(12-15)24(32)33-3/h6-7,9-11,15H,4-5,8,12-13H2,1-3H3,(H,27,31) NKHHRLBCVCBDBN-UHFFFAOYSA-N 50592268 CHEMBL5207941 P2X purinoceptor 3 Homo sapiens 244 ChEMBL 10.7270/Q2SX6J56 35644300 Bae, J; Kang, KM; Kim, YC Gwangju Institute of Science and Technology (GIST) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592268 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592268&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 168295731 482603120 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51467780 CCC(=O)N1CCCC(Cn2c(nc3cc(C)ccc23)-c2c(F)cc(cc2F)C(=O)NC)C1 InChI=1S/C25H28F2N4O2/c1-4-22(32)30-9-5-6-16(13-30)14-31-21-8-7-15(2)10-20(21)29-24(31)23-18(26)11-17(12-19(23)27)25(33)28-3/h7-8,10-12,16H,4-6,9,13-14H2,1-3H3,(H,28,33) VIDZKOPDDHQZDL-UHFFFAOYSA-N 50592269 CHEMBL5172174 P2X purinoceptor 3 Homo sapiens 227 ChEMBL 10.7270/Q2SX6J56 35644300 Bae, J; Kang, KM; Kim, YC Gwangju Institute of Science and Technology (GIST) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592269 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592269&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 168269639 482603121 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51467781 COC(=O)N1CCC(Cn2c(Cc3ccc(Cl)cc3)nc3cc(C)ccc23)CC1 InChI=1S/C23H26ClN3O2/c1-16-3-8-21-20(13-16)25-22(14-17-4-6-19(24)7-5-17)27(21)15-18-9-11-26(12-10-18)23(28)29-2/h3-8,13,18H,9-12,14-15H2,1-2H3 UWIVCUPYGZJQHQ-UHFFFAOYSA-N 50592270 CHEMBL5204294 P2X purinoceptor 3 Homo sapiens 145 ChEMBL 10.7270/Q2SX6J56 35644300 Bae, J; Kang, KM; Kim, YC Gwangju Institute of Science and Technology (GIST) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592270 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592270&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 168294120 482603122 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51467782 CCC(=O)N1CCC(Cn2c(Cc3ccc(Cl)cc3)nc3cc(C)ccc23)CC1 InChI=1S/C24H28ClN3O/c1-3-24(29)27-12-10-19(11-13-27)16-28-22-9-4-17(2)14-21(22)26-23(28)15-18-5-7-20(25)8-6-18/h4-9,14,19H,3,10-13,15-16H2,1-2H3 KNFOCBIYILAWQH-UHFFFAOYSA-N 50592271 CHEMBL5205988 P2X purinoceptor 3 Homo sapiens 206 ChEMBL 10.7270/Q2SX6J56 35644300 Bae, J; Kang, KM; Kim, YC Gwangju Institute of Science and Technology (GIST) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592271 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592271&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 168296227 482603123 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51467783 COC(=O)N1CCC(Cn2c(Cc3ccc(cc3)C(F)(F)F)nc3cc(C)ccc23)CC1 InChI=1S/C24H26F3N3O2/c1-16-3-8-21-20(13-16)28-22(14-17-4-6-19(7-5-17)24(25,26)27)30(21)15-18-9-11-29(12-10-18)23(31)32-2/h3-8,13,18H,9-12,14-15H2,1-2H3 BTVQKXCUNPPJQB-UHFFFAOYSA-N 50592272 CHEMBL5176300 P2X purinoceptor 3 Homo sapiens 272 ChEMBL 10.7270/Q2SX6J56 35644300 Bae, J; Kang, KM; Kim, YC Gwangju Institute of Science and Technology (GIST) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592272 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592272&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 168276143 482603124 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51467784 CCC(=O)N1CCC(Cn2c(Cc3ccc(cc3)C(F)(F)F)nc3cc(C)ccc23)CC1 InChI=1S/C25H28F3N3O/c1-3-24(32)30-12-10-19(11-13-30)16-31-22-9-4-17(2)14-21(22)29-23(31)15-18-5-7-20(8-6-18)25(26,27)28/h4-9,14,19H,3,10-13,15-16H2,1-2H3 ATQUAIJVNLHVFG-UHFFFAOYSA-N 50592273 CHEMBL5174938 P2X purinoceptor 3 Homo sapiens 306 ChEMBL 10.7270/Q2SX6J56 35644300 Bae, J; Kang, KM; Kim, YC Gwangju Institute of Science and Technology (GIST) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592273 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592273&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 168277721 482603125 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51467785 COC(=O)N1CCC(Cn2c(Cc3ccccc3)nc3cc(C)ccc23)CC1 InChI=1S/C23H27N3O2/c1-17-8-9-21-20(14-17)24-22(15-18-6-4-3-5-7-18)26(21)16-19-10-12-25(13-11-19)23(27)28-2/h3-9,14,19H,10-13,15-16H2,1-2H3 GYOFZMDAUCITIP-UHFFFAOYSA-N 50592274 CHEMBL5183843 P2X purinoceptor 3 Homo sapiens 364 ChEMBL 10.7270/Q2SX6J56 35644300 Bae, J; Kang, KM; Kim, YC Gwangju Institute of Science and Technology (GIST) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592274 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592274&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 168282141 482603126 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51467786 CCC(=O)N1CCC(Cn2c(Cc3ccccc3)nc3cc(C)ccc23)CC1 InChI=1S/C24H29N3O/c1-3-24(28)26-13-11-20(12-14-26)17-27-22-10-9-18(2)15-21(22)25-23(27)16-19-7-5-4-6-8-19/h4-10,15,20H,3,11-14,16-17H2,1-2H3 BKEABCFSCRFRJE-UHFFFAOYSA-N 50592275 CHEMBL5173780 P2X purinoceptor 3 Homo sapiens 4680 ChEMBL 10.7270/Q2SX6J56 35644300 Bae, J; Kang, KM; Kim, YC Gwangju Institute of Science and Technology (GIST) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592275 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592275&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 168275265 482603127 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51467787 COC(=O)N1CCC(Cn2c(Cc3ccc(OC)cc3)nc3cc(C)ccc23)CC1 InChI=1S/C24H29N3O3/c1-17-4-9-22-21(14-17)25-23(15-18-5-7-20(29-2)8-6-18)27(22)16-19-10-12-26(13-11-19)24(28)30-3/h4-9,14,19H,10-13,15-16H2,1-3H3 JAIMMABYHGQRRG-UHFFFAOYSA-N 50592276 CHEMBL5183644 P2X purinoceptor 3 Homo sapiens 4150 ChEMBL 10.7270/Q2SX6J56 35644300 Bae, J; Kang, KM; Kim, YC Gwangju Institute of Science and Technology (GIST) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592276 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592276&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 168281280 482603128 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51467788 CCC(=O)N1CCC(Cn2c(Cc3ccc(OC)cc3)nc3cc(C)ccc23)CC1 InChI=1S/C25H31N3O2/c1-4-25(29)27-13-11-20(12-14-27)17-28-23-10-5-18(2)15-22(23)26-24(28)16-19-6-8-21(30-3)9-7-19/h5-10,15,20H,4,11-14,16-17H2,1-3H3 IKEWMYOELJUHNN-UHFFFAOYSA-N 50592277 CHEMBL5188031 P2X purinoceptor 3 Homo sapiens 1070 ChEMBL 10.7270/Q2SX6J56 35644300 Bae, J; Kang, KM; Kim, YC Gwangju Institute of Science and Technology (GIST) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592277 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592277&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 168279353 482603129 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51468940 Clc1ccc(Cn2c3c(nc(Cl)nc3n(CC(=O)Nc3ccc(Cl)cc3)c2=O)N2CCOCC2)cc1 InChI=1S/C24H21Cl3N6O3/c25-16-3-1-15(2-4-16)13-32-20-21(31-9-11-36-12-10-31)29-23(27)30-22(20)33(24(32)35)14-19(34)28-18-7-5-17(26)6-8-18/h1-8H,9-14H2,(H,28,34) ZKPPECAMJDRQNC-UHFFFAOYSA-N 50592832 CHEMBL5178333 P2X purinoceptor 3 Homo sapiens 3070 ChEMBL 10.1016/j.bmcl.2005.03.007 10.7270/Q2N301X2 15837310 Kang, KM; Lee, I; Nam, H; Kim, YC Gwangju Institute of Science and Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592832 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592832&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 168273716 482603684 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51468941 Fc1ccc(NC(=O)Cn2c3nc(Cl)nc(N4CCOCC4)c3n(Cc3ccc(Cl)cc3)c2=O)cc1F InChI=1S/C24H20Cl2F2N6O3/c25-15-3-1-14(2-4-15)12-33-20-21(32-7-9-37-10-8-32)30-23(26)31-22(20)34(24(33)36)13-19(35)29-16-5-6-17(27)18(28)11-16/h1-6,11H,7-10,12-13H2,(H,29,35) QXPAJJLRYLWOSZ-UHFFFAOYSA-N 50592833 CHEMBL5178054 P2X purinoceptor 3 Homo sapiens 3430 ChEMBL 10.1016/j.bmcl.2005.03.007 10.7270/Q2N301X2 15837310 Kang, KM; Lee, I; Nam, H; Kim, YC Gwangju Institute of Science and Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592833 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592833&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 168275055 482603685 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51468942 Cc1cc(\C=N\NC(=O)c2cc3c(ccc4ccccc34)o2)c(C)n1-c1ccc(cc1)C(O)=O InChI=1S/C27H21N3O4/c1-16-13-20(17(2)30(16)21-10-7-19(8-11-21)27(32)33)15-28-29-26(31)25-14-23-22-6-4-3-5-18(22)9-12-24(23)34-25/h3-15H,1-2H3,(H,29,31)(H,32,33)/b28-15+ VEHCJXXXQGBSHB-RWPZCVJISA-N 50592834 CHEMBL5186736 P2X purinoceptor 3 Homo sapiens 5610 ChEMBL 10.1016/j.bmcl.2005.03.007 10.7270/Q2N301X2 15837310 Kang, KM; Lee, I; Nam, H; Kim, YC Gwangju Institute of Science and Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592834 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592834&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 9641155 482603686 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51468943 Clc1ccc(Cn2c3c(nc(Cl)nc3n(CC(=O)Nc3ccccc3)c2=O)N2CCOCC2)cc1 InChI=1S/C24H22Cl2N6O3/c25-17-8-6-16(7-9-17)14-31-20-21(30-10-12-35-13-11-30)28-23(26)29-22(20)32(24(31)34)15-19(33)27-18-4-2-1-3-5-18/h1-9H,10-15H2,(H,27,33) ULOOZIZLBNRNAM-UHFFFAOYSA-N 50592835 CHEMBL5199426 P2X purinoceptor 3 Homo sapiens 8720 ChEMBL 10.1016/j.bmcl.2005.03.007 10.7270/Q2N301X2 15837310 Kang, KM; Lee, I; Nam, H; Kim, YC Gwangju Institute of Science and Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592835 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592835&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 168291934 482603687 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51468944 [O-][n+]1ccc(CC(c2ccc(OC(F)F)c(OCC3CC3)c2)n2ccc(n2)-c2cccc(NC(=O)c3ccccc3)c2)cc1 InChI=1S/C34H30F2N4O4/c35-34(36)44-31-12-11-27(21-32(31)43-22-24-9-10-24)30(19-23-13-16-39(42)17-14-23)40-18-15-29(38-40)26-7-4-8-28(20-26)37-33(41)25-5-2-1-3-6-25/h1-8,11-18,20-21,24,30,34H,9-10,19,22H2,(H,37,41) HEGXYQLDVWSIOY-UHFFFAOYSA-N 50592836 CHEMBL5201961 P2X purinoceptor 3 Homo sapiens 9760 ChEMBL 10.1016/j.bmcl.2005.03.007 10.7270/Q2N301X2 15837310 Kang, KM; Lee, I; Nam, H; Kim, YC Gwangju Institute of Science and Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592836 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592836&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 168292321 482603688 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51468945 COc1ccc(cc1OC1CCCC1)-c1csc(NC(=O)c2ccc(cc2)S(F)(=O)=O)n1 InChI=1S/C22H21FN2O5S2/c1-29-19-11-8-15(12-20(19)30-16-4-2-3-5-16)18-13-31-22(24-18)25-21(26)14-6-9-17(10-7-14)32(23,27)28/h6-13,16H,2-5H2,1H3,(H,24,25,26) KYAWKKGMWPGMOB-UHFFFAOYSA-N 50592837 CHEMBL5175267 P2X purinoceptor 3 Homo sapiens 10400 ChEMBL 10.1016/j.bmcl.2005.03.007 10.7270/Q2N301X2 15837310 Kang, KM; Lee, I; Nam, H; Kim, YC Gwangju Institute of Science and Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592837 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592837&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 168275365 482603689 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51468946 O=C(NOC1CCCCO1)c1ccc(\C=C(/CNC2CCCCC2)COc2cccc3ccccc23)cc1 InChI=1S/C32H38N2O4/c35-32(34-38-31-15-6-7-20-36-31)27-18-16-24(17-19-27)21-25(22-33-28-11-2-1-3-12-28)23-37-30-14-8-10-26-9-4-5-13-29(26)30/h4-5,8-10,13-14,16-19,21,28,31,33H,1-3,6-7,11-12,15,20,22-23H2,(H,34,35)/b25-21+ YHRRVGZBEGCGDS-NJNXFGOHSA-N 50592838 CHEMBL5194075 P2X purinoceptor 3 Homo sapiens 11500 ChEMBL 10.1016/j.bmcl.2005.03.007 10.7270/Q2N301X2 15837310 Kang, KM; Lee, I; Nam, H; Kim, YC Gwangju Institute of Science and Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592838 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592838&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 168287471 482603690 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51468947 CCOc1ccc(cc1Cl)C(=O)Nc1ccc(Cl)c(c1)-c1nc2ncccc2o1 InChI=1S/C21H15Cl2N3O3/c1-2-28-17-8-5-12(10-16(17)23)20(27)25-13-6-7-15(22)14(11-13)21-26-19-18(29-21)4-3-9-24-19/h3-11H,2H2,1H3,(H,25,27) OMNWSABIUCCXNY-UHFFFAOYSA-N 50592839 CHEMBL5194597 P2X purinoceptor 3 Homo sapiens 13800 ChEMBL 10.1016/j.bmcl.2005.03.007 10.7270/Q2N301X2 15837310 Kang, KM; Lee, I; Nam, H; Kim, YC Gwangju Institute of Science and Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592839 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592839&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 2880559 482603691 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51468948 CCCCc1nc2cc(-c3ccccc3)c(C=O)nc2n1CCCN1CCC(CC1)c1cccc(NC(=O)C(C)C)c1 InChI=1S/C35H43N5O2/c1-4-5-15-33-37-31-23-30(27-11-7-6-8-12-27)32(24-41)38-34(31)40(33)19-10-18-39-20-16-26(17-21-39)28-13-9-14-29(22-28)36-35(42)25(2)3/h6-9,11-14,22-26H,4-5,10,15-21H2,1-3H3,(H,36,42) GMCGVFZGCFVHRD-UHFFFAOYSA-N 50592840 CHEMBL5193198 P2X purinoceptor 3 Homo sapiens 18400 ChEMBL 10.1016/j.bmcl.2005.03.007 10.7270/Q2N301X2 15837310 Kang, KM; Lee, I; Nam, H; Kim, YC Gwangju Institute of Science and Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592840 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592840&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 59365342 482603692 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51468949 ONC(=O)c1ccc(\C=C(\CNC2CCN(Cc3ccccc3)C2)COc2cccc3ccccc23)cc1 InChI=1S/C32H33N3O3/c36-32(34-37)28-15-13-24(14-16-28)19-26(23-38-31-12-6-10-27-9-4-5-11-30(27)31)20-33-29-17-18-35(22-29)21-25-7-2-1-3-8-25/h1-16,19,29,33,37H,17-18,20-23H2,(H,34,36)/b26-19- WCSCAJOENTXFBE-XHPQRKPJSA-N 50592841 CHEMBL5185378 P2X purinoceptor 3 Homo sapiens 21900 ChEMBL 10.1016/j.bmcl.2005.03.007 10.7270/Q2N301X2 15837310 Kang, KM; Lee, I; Nam, H; Kim, YC Gwangju Institute of Science and Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592841 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592841&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 24900038 482603693 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51468950 CCOC(=O)C1=C(C)N=c2s\c(=C/c3ccc(cc3OC)N(CC)CC)c(=O)n2C1c1ccc2OCOc2c1 InChI=1S/C29H31N3O6S/c1-6-31(7-2)20-11-9-18(22(15-20)35-5)14-24-27(33)32-26(19-10-12-21-23(13-19)38-16-37-21)25(28(34)36-8-3)17(4)30-29(32)39-24/h9-15,26H,6-8,16H2,1-5H3/b24-14- GFZAGALBJGOBJN-OYKKKHCWSA-N 50592842 CHEMBL5170554 P2X purinoceptor 3 Homo sapiens 1930 ChEMBL 10.1016/j.bmcl.2005.03.007 10.7270/Q2N301X2 15837310 Kang, KM; Lee, I; Nam, H; Kim, YC Gwangju Institute of Science and Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592842 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592842&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 5724855 482603694 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51468951 CCOc1ccc(cc1C)-c1nn(cc1\C=C1\SC(=S)N(CCC(O)=O)C1=O)-c1ccccc1 InChI=1S/C25H23N3O4S2/c1-3-32-20-10-9-17(13-16(20)2)23-18(15-28(26-23)19-7-5-4-6-8-19)14-21-24(31)27(25(33)34-21)12-11-22(29)30/h4-10,13-15H,3,11-12H2,1-2H3,(H,29,30)/b21-14+ PUYYKYHFODSMQI-KGENOOAVSA-N 50592843 CHEMBL5182519 P2X purinoceptor 3 Homo sapiens 8560 ChEMBL 10.1016/j.bmcl.2005.03.007 10.7270/Q2N301X2 15837310 Kang, KM; Lee, I; Nam, H; Kim, YC Gwangju Institute of Science and Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592843 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592843&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 1315238 482603695 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51468952 Clc1cccc(OCc2ccc(o2)C(=O)Nc2nc3ccccc3n2CCN2CCOCC2)c1 InChI=1S/C25H25ClN4O4/c26-18-4-3-5-19(16-18)33-17-20-8-9-23(34-20)24(31)28-25-27-21-6-1-2-7-22(21)30(25)11-10-29-12-14-32-15-13-29/h1-9,16H,10-15,17H2,(H,27,28,31) MUIZPZRGJFFIQB-UHFFFAOYSA-N 50592844 CHEMBL5191901 P2X purinoceptor 3 Homo sapiens 10900 ChEMBL 10.1016/j.bmcl.2005.03.007 10.7270/Q2N301X2 15837310 Kang, KM; Lee, I; Nam, H; Kim, YC Gwangju Institute of Science and Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592844 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592844&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 168284555 482603696 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51468953 OCCN(CCO)C[C@@H](O)Cn1c2ccc(Br)cc2c2cc(Br)ccc12 InChI=1S/C19H22Br2N2O3/c20-13-1-3-18-16(9-13)17-10-14(21)2-4-19(17)23(18)12-15(26)11-22(5-7-24)6-8-25/h1-4,9-10,15,24-26H,5-8,11-12H2/t15-/m1/s1 QCHVBMYVHVSEJH-OAHLLOKOSA-N 50592845 CHEMBL5182831 P2X purinoceptor 3 Homo sapiens 13400 ChEMBL 10.1016/j.bmcl.2005.03.007 10.7270/Q2N301X2 15837310 Kang, KM; Lee, I; Nam, H; Kim, YC Gwangju Institute of Science and Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592845 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592845&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 981332 482603697 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51468954 CCCCCCCCOC(=O)[C@H](NS(=O)(=O)c1ccc2ccccc2c1)[C@@H](C)c1ccccc1 InChI=1S/C28H35NO4S/c1-3-4-5-6-7-13-20-33-28(30)27(22(2)23-14-9-8-10-15-23)29-34(31,32)26-19-18-24-16-11-12-17-25(24)21-26/h8-12,14-19,21-22,27,29H,3-7,13,20H2,1-2H3/t22-,27+/m0/s1 CFMKDCIGAAMXLK-WXVAWEFUSA-N 50592846 CHEMBL5196092 P2X purinoceptor 3 Homo sapiens 15500 ChEMBL 10.1016/j.bmcl.2005.03.007 10.7270/Q2N301X2 15837310 Kang, KM; Lee, I; Nam, H; Kim, YC Gwangju Institute of Science and Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592846 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592846&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 168287180 482603698 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51468955 CCCCC(=O)Oc1ccc2N(CCc3ccc(C)cc3)C(=O)C(NCc2c1)C(C)C InChI=1S/C26H34N2O3/c1-5-6-7-24(29)31-22-12-13-23-21(16-22)17-27-25(18(2)3)26(30)28(23)15-14-20-10-8-19(4)9-11-20/h8-13,16,18,25,27H,5-7,14-15,17H2,1-4H3 RVLUARZXTCHTGG-UHFFFAOYSA-N 50592847 CHEMBL5192824 P2X purinoceptor 3 Homo sapiens 19000 ChEMBL 10.1016/j.bmcl.2005.03.007 10.7270/Q2N301X2 15837310 Kang, KM; Lee, I; Nam, H; Kim, YC Gwangju Institute of Science and Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592847 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592847&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 168289479 482603699 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51468956 CCC(=O)N1CCOC(Cc2c(nc3cc(C)ccn23)-c2c(C)cc(cc2C)C(=O)NC)C1 InChI=1S/C26H32N4O3/c1-6-23(31)29-9-10-33-20(15-29)14-21-25(28-22-11-16(2)7-8-30(21)22)24-17(3)12-19(13-18(24)4)26(32)27-5/h7-8,11-13,20H,6,9-10,14-15H2,1-5H3,(H,27,32) IPSGCXWQMHMOKK-UHFFFAOYSA-N 50592848 CHEMBL5186232 P2X purinoceptor 3 Homo sapiens 3.0 ChEMBL 10.1016/j.bmcl.2005.03.007 10.7270/Q2N301X2 15837310 Kang, KM; Lee, I; Nam, H; Kim, YC Gwangju Institute of Science and Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592848 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592848&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 168282658 482603700 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51468957 COc1cc(C(C)C)c(Oc2cnc(N)nc2N)cc1S(N)(=O)=O InChI=1S/C14H19N5O4S/c1-7(2)8-4-10(22-3)12(24(17,20)21)5-9(8)23-11-6-18-14(16)19-13(11)15/h4-7H,1-3H3,(H2,17,20,21)(H4,15,16,18,19) HLWURFKMDLAKOD-UHFFFAOYSA-N 50533006 Af-219::Gefapixant::R-1646::R1646::RG-1646::RG1646::RO-4926219::RO4926219 P2X purinoceptor 3 Homo sapiens 45 ChEMBL 10.1016/j.bmcl.2005.03.007 10.7270/Q2N301X2 15837310 Kang, KM; Lee, I; Nam, H; Kim, YC Gwangju Institute of Science and Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533006 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533006&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search AF9 5YVE 24764487 440741588 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51468958 CNC(=O)c1cc(F)c(-c2nc3cc(C)ccn3c2C[C@@H]2CCCN(C2)C(=O)OC)c(F)c1 InChI=1S/C24H26F2N4O3/c1-14-6-8-30-19(10-15-5-4-7-29(13-15)24(32)33-3)22(28-20(30)9-14)21-17(25)11-16(12-18(21)26)23(31)27-2/h6,8-9,11-12,15H,4-5,7,10,13H2,1-3H3,(H,27,31)/t15-/m0/s1 HHJIZLMOCIYWJF-HNNXBMFYSA-N 50592849 CHEMBL5207245 P2X purinoceptor 3 Homo sapiens 25 ChEMBL 10.1016/j.bmcl.2005.03.007 10.7270/Q2N301X2 15837310 Kang, KM; Lee, I; Nam, H; Kim, YC Gwangju Institute of Science and Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592849 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592849&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 132129813 482603701 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51468959 C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F InChI=1S/C22H21F3N4O3S/c1-12-8-26-20(33-12)15-5-14(6-18(7-15)32-17-3-4-31-11-17)19(30)29-13(2)16-9-27-21(28-10-16)22(23,24)25/h5-10,13,17H,3-4,11H2,1-2H3,(H,29,30)/t13-,17-/m1/s1 GTQPEQGDLVSFJO-CXAGYDPISA-N 319844 3-(5-Methyl-1,3-thiazol-2-yl)-5-[(3R)-tetrahydrofuran-3-yloxy]-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 11::US10202369, Example 11::US10472354, Example 291 P2X purinoceptor 3 Homo sapiens 8.0 ChEMBL 10.1016/j.bmcl.2005.03.007 10.7270/Q2N301X2 15837310 Kang, KM; Lee, I; Nam, H; Kim, YC Gwangju Institute of Science and Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319844 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319844&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 121397587 384223124 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51468960 C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O 271626 US10065941, Compound I-127::US9732060, Compound I-127 P2X purinoceptor 3 Homo sapiens 4.2 ChEMBL 10.1016/j.bmcl.2005.03.007 10.7270/Q2N301X2 15837310 Kang, KM; Lee, I; Nam, H; Kim, YC Gwangju Institute of Science and Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=271626 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=271626&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 117752163 378153454 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51461816 Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@H]2OC3(O[C@@H]12)C(=CC(C=C3[N+]([O-])=O)[N+]([O-])=O)[N+]([O-])=O InChI=1S/C16H17N8O19P3/c17-13-10-14(19-4-18-13)21(5-20-10)15-12-11(7(39-15)3-38-45(34,35)43-46(36,37)42-44(31,32)33)40-16(41-12)8(23(27)28)1-6(22(25)26)2-9(16)24(29)30/h1-2,4-7,11-12,15H,3H2,(H,34,35)(H,36,37)(H2,17,18,19)(H2,31,32,33)/t6?,7-,11-,12-,15-,16?/m1/s1 TXMXHIVKIUHZFM-YKWNPASPSA-N 50540410 CHEMBL337395 P2X purinoceptor 3 Homo sapiens 18 ChEMBL 10.7270/Q2RX9H1T 36150180 Toti, KS; Verma, R; McGonnigle, MJ; Gamiotea Turro, D; Wen, Z; Lewicki, SA; Liang, BT; Jacobson, KA National Institute of Diabetes and Digestive and Kidney Diseases http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50540410 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50540410&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 11542191 442141973 C03517 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51473539 COc1ccc(cc1)C(=O)O[C@@H]1[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]([C@@H]1OC(=O)c1ccc(OC)cc1)n1cnc2c(N)ncnc12 InChI=1S/C26H28N5O17P3/c1-41-16-7-3-14(4-8-16)25(32)45-20-18(11-43-50(37,38)48-51(39,40)47-49(34,35)36)44-24(31-13-30-19-22(27)28-12-29-23(19)31)21(20)46-26(33)15-5-9-17(42-2)10-6-15/h3-10,12-13,18,20-21,24H,11H2,1-2H3,(H,37,38)(H,39,40)(H2,27,28,29)(H2,34,35,36)/t18-,20-,21-,24-/m1/s1 RKFOOQRRMNOARS-UMCMBGNQSA-N 50594494 CHEMBL5197509 P2X purinoceptor 3 Homo sapiens <100000 ChEMBL 10.7270/Q2XS60DK 35930402 Isaak, A; Dobelmann, C; Füsser, FT; Erlitz, KS; Koch, O; Junker, A European Institute for Molecular Imaging (EIMI) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50594494 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50594494&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 168284464 482605346 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51473540 Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1F InChI=1S/C10H15FN5O12P3/c11-5-7(17)4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(5)16-3-15-6-8(12)13-2-14-9(6)16/h2-5,7,10,17H,1H2,(H,21,22)(H,23,24)(H2,12,13,14)(H2,18,19,20)/t4-,5-,7-,10-/m1/s1 CCXCDDWASROAJA-QYYRPYCUSA-N 50594495 CHEMBL4576110 P2X purinoceptor 3 Homo sapiens 10471 ChEMBL 10.7270/Q2XS60DK 35930402 Isaak, A; Dobelmann, C; Füsser, FT; Erlitz, KS; Koch, O; Junker, A European Institute for Molecular Imaging (EIMI) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50594495 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50594495&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 126365 482605347 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51473541 N[C@@H]1[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]1n1cnc2c(N)ncnc12 InChI=1S/C10H17N6O12P3/c11-5-7(17)4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(5)16-3-15-6-8(12)13-2-14-9(6)16/h2-5,7,10,17H,1,11H2,(H,21,22)(H,23,24)(H2,12,13,14)(H2,18,19,20)/t4-,5-,7-,10-/m1/s1 BPRNAIIYYOQQKN-QYYRPYCUSA-N 50594496 CHEMBL4582937 P2X purinoceptor 3 Homo sapiens 4266 ChEMBL 10.7270/Q2XS60DK 35930402 Isaak, A; Dobelmann, C; Füsser, FT; Erlitz, KS; Koch, O; Junker, A European Institute for Molecular Imaging (EIMI) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50594496 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50594496&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 50997601 482605348 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51473542 CO[C@@H]1[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]1n1cnc2c(N)ncnc12 InChI=1S/C11H18N5O13P3/c1-25-8-7(17)5(2-26-31(21,22)29-32(23,24)28-30(18,19)20)27-11(8)16-4-15-6-9(12)13-3-14-10(6)16/h3-5,7-8,11,17H,2H2,1H3,(H,21,22)(H,23,24)(H2,12,13,14)(H2,18,19,20) OARVGPYQJRLYFE-UHFFFAOYSA-N 50026197 Adenosine 5'-triphosphate derivative::CHEMBL3142844 P2X purinoceptor 3 Homo sapiens <100000 ChEMBL 10.7270/Q2XS60DK 35930402 Isaak, A; Dobelmann, C; Füsser, FT; Erlitz, KS; Koch, O; Junker, A European Institute for Molecular Imaging (EIMI) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50026197 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50026197&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 3012940 103935931 CHEMBL3142844CHEMBL109409 C03517 ZINC43335443 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51473543 Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@@H]1O InChI=1S/C10H16N5O13P3/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7+,10-/m1/s1 ZKHQWZAMYRWXGA-UHTZMRCNSA-N 50594497 CHEMBL4441501 P2X purinoceptor 3 Homo sapiens <100000 ChEMBL 10.7270/Q2XS60DK 35930402 Isaak, A; Dobelmann, C; Füsser, FT; Erlitz, KS; Koch, O; Junker, A European Institute for Molecular Imaging (EIMI) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50594497 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50594497&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search HEJ 65128 482605349 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51473544 O[C@@H]1[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]([C@@H]1O)n1cnc2c(Cl)ncnc12 InChI=1S/C10H14ClN4O13P3/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1 WNBYTJKDDLUPCV-KQYNXXCUSA-N 526264 US11185100, TABLE 14.4 P2X purinoceptor 3 Homo sapiens 741 ChEMBL 10.7270/Q2XS60DK 35930402 Isaak, A; Dobelmann, C; Füsser, FT; Erlitz, KS; Koch, O; Junker, A European Institute for Molecular Imaging (EIMI) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=526264 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=526264&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 6453225 463789904 C03517 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51473545 O[C@@H]1[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]([C@@H]1O)n1cnc2c(S)ncnc12 InChI=1S/C10H15N4O13P3S/c15-6-4(1-24-29(20,21)27-30(22,23)26-28(17,18)19)25-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)31/h2-4,6-7,10,15-16H,1H2,(H,20,21)(H,22,23)(H,11,12,31)(H2,17,18,19)/t4-,6-,7-,10-/m1/s1 GQNRDWAOABGWGP-KQYNXXCUSA-N 50594498 CHEMBL4583478 P2X purinoceptor 3 Homo sapiens 1514 ChEMBL 10.7270/Q2XS60DK 35930402 Isaak, A; Dobelmann, C; Füsser, FT; Erlitz, KS; Koch, O; Junker, A European Institute for Molecular Imaging (EIMI) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50594498 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50594498&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 3036942 482605350 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51473546 CNc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O InChI=1S/C11H18N5O13P3/c1-12-9-6-10(14-3-13-9)16(4-15-6)11-8(18)7(17)5(27-11)2-26-31(22,23)29-32(24,25)28-30(19,20)21/h3-5,7-8,11,17-18H,2H2,1H3,(H,22,23)(H,24,25)(H,12,13,14)(H2,19,20,21)/t5-,7-,8-,11-/m1/s1 LCQWKKZWHQFOAH-IOSLPCCCSA-N 50318030 ((2R,3S,4R,5R)-3,4-dihydroxy-5-(6-(methylamino)-9H-purin-9-yl)tetrahydrofuran-2-yl)methyltriphosphate tetraammonium salt::CHEMBL1094109 P2X purinoceptor 3 Homo sapiens 1288 ChEMBL 10.7270/Q2XS60DK 35930402 Isaak, A; Dobelmann, C; Füsser, FT; Erlitz, KS; Koch, O; Junker, A European Institute for Molecular Imaging (EIMI) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50318030 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50318030&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search N6E 6TFE 49797718 104152391 CHEMBL1094109 C03517 ZINC49774268 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51473547 CCCCNc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O InChI=1S/C14H24N5O13P3/c1-2-3-4-15-12-9-13(17-6-16-12)19(7-18-9)14-11(21)10(20)8(30-14)5-29-34(25,26)32-35(27,28)31-33(22,23)24/h6-8,10-11,14,20-21H,2-5H2,1H3,(H,25,26)(H,27,28)(H,15,16,17)(H2,22,23,24)/t8-,10-,11-,14-/m1/s1 LDLJTALPLRVDBD-IDTAVKCVSA-N 50594499 CHEMBL5171786 P2X purinoceptor 3 Homo sapiens 30200 ChEMBL 10.7270/Q2XS60DK 35930402 Isaak, A; Dobelmann, C; Füsser, FT; Erlitz, KS; Koch, O; Junker, A European Institute for Molecular Imaging (EIMI) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50594499 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50594499&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 168270465 482605351 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51473548 O[C@@H]1[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]([C@@H]1O)n1cnc2c(Nc3ccccc3)ncnc12 InChI=1S/C16H20N5O13P3/c22-12-10(6-31-36(27,28)34-37(29,30)33-35(24,25)26)32-16(13(12)23)21-8-19-11-14(17-7-18-15(11)21)20-9-4-2-1-3-5-9/h1-5,7-8,10,12-13,16,22-23H,6H2,(H,27,28)(H,29,30)(H,17,18,20)(H2,24,25,26)/t10-,12-,13-,16-/m1/s1 MXSCITZYHDRLLP-XNIJJKJLSA-N 50594500 CHEMBL5202979 P2X purinoceptor 3 Homo sapiens 209 ChEMBL 10.7270/Q2XS60DK 35930402 Isaak, A; Dobelmann, C; Füsser, FT; Erlitz, KS; Koch, O; Junker, A European Institute for Molecular Imaging (EIMI) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50594500 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50594500&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 44755145 482605352 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51473549 O[C@@H]1[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]([C@@H]1O)n1cnc2c(NCc3ccccc3)ncnc12 InChI=1S/C17H22N5O13P3/c23-13-11(7-32-37(28,29)35-38(30,31)34-36(25,26)27)33-17(14(13)24)22-9-21-12-15(19-8-20-16(12)22)18-6-10-4-2-1-3-5-10/h1-5,8-9,11,13-14,17,23-24H,6-7H2,(H,28,29)(H,30,31)(H,18,19,20)(H2,25,26,27)/t11-,13-,14-,17-/m1/s1 NUUDCFZWGUJXPV-LSCFUAHRSA-N 50594501 CHEMBL5170304 P2X purinoceptor 3 Homo sapiens <100000 ChEMBL 10.7270/Q2XS60DK 35930402 Isaak, A; Dobelmann, C; Füsser, FT; Erlitz, KS; Koch, O; Junker, A European Institute for Molecular Imaging (EIMI) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50594501 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50594501&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 44755036 482605353 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51473550 O[C@@H]1[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]([C@@H]1O)n1cnc2c3nccn3cnc12 InChI=1S/C12H16N5O13P3/c18-8-6(3-27-32(23,24)30-33(25,26)29-31(20,21)22)28-12(9(8)19)17-5-14-7-10-13-1-2-16(10)4-15-11(7)17/h1-2,4-6,8-9,12,18-19H,3H2,(H,23,24)(H,25,26)(H2,20,21,22)/t6-,8-,9-,12-/m1/s1 BKQZGVPRPNNNDW-WOUKDFQISA-N 50594502 CHEMBL5200154 P2X purinoceptor 3 Homo sapiens 1000 ChEMBL 10.7270/Q2XS60DK 35930402 Isaak, A; Dobelmann, C; Füsser, FT; Erlitz, KS; Koch, O; Junker, A European Institute for Molecular Imaging (EIMI) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50594502 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50594502&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 14130517 482605354 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51473551 Nc1ncnc2n([C@@H]3O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]3O)c(N=[N+]=[N-])nc12 InChI=1S/C10H15N8O13P3/c11-7-4-8(14-2-13-7)18(10(15-4)16-17-12)9-6(20)5(19)3(29-9)1-28-33(24,25)31-34(26,27)30-32(21,22)23/h2-3,5-6,9,19-20H,1H2,(H,24,25)(H,26,27)(H2,11,13,14)(H2,21,22,23)/t3-,5-,6-,9-/m1/s1 PQISXOFEOCLOCT-UUOKFMHZSA-N 50594503 CHEMBL4567276 P2X purinoceptor 3 Homo sapiens <100000 ChEMBL 10.7270/Q2XS60DK 35930402 Isaak, A; Dobelmann, C; Füsser, FT; Erlitz, KS; Koch, O; Junker, A European Institute for Molecular Imaging (EIMI) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50594503 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50594503&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 2735431 482605355 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51473552 O[C@@H]1[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]([C@@H]1O)n1c2ncncc2[nH]c1=O 50594504 CHEMBL5170556 P2X purinoceptor 3 Homo sapiens 10965 ChEMBL 10.7270/Q2XS60DK 35930402 Isaak, A; Dobelmann, C; Füsser, FT; Erlitz, KS; Koch, O; Junker, A European Institute for Molecular Imaging (EIMI) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50594504 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50594504&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 168270309 482605356 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51473553 Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](OC(=O)c2ccccc2)[C@H]1OC(=O)c1ccccc1 InChI=1S/C24H24N5O15P3/c25-20-17-21(27-12-26-20)29(13-28-17)22-19(42-24(31)15-9-5-2-6-10-15)18(41-23(30)14-7-3-1-4-8-14)16(40-22)11-39-46(35,36)44-47(37,38)43-45(32,33)34/h1-10,12-13,16,18-19,22H,11H2,(H,35,36)(H,37,38)(H2,25,26,27)(H2,32,33,34)/t16-,18-,19-,22-/m1/s1 IKEQMDLYPNVQGH-WGQQHEPDSA-N 50594505 CHEMBL5177316 P2X purinoceptor 3 Homo sapiens <100000 ChEMBL 10.7270/Q2XS60DK 35930402 Isaak, A; Dobelmann, C; Füsser, FT; Erlitz, KS; Koch, O; Junker, A European Institute for Molecular Imaging (EIMI) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50594505 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50594505&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 5311061 482605357 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51473554 Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](OC(=O)c2cccc3ccccc23)[C@H]1OC(=O)c1cccc2ccccc12 InChI=1S/C32H28N5O15P3/c33-28-25-29(35-16-34-28)37(17-36-25)30-27(50-32(39)23-14-6-10-19-8-2-4-12-21(19)23)26(49-31(38)22-13-5-9-18-7-1-3-11-20(18)22)24(48-30)15-47-54(43,44)52-55(45,46)51-53(40,41)42/h1-14,16-17,24,26-27,30H,15H2,(H,43,44)(H,45,46)(H2,33,34,35)(H2,40,41,42)/t24-,26-,27-,30-/m1/s1 PSBROSWEMLTASJ-BQOYKFDPSA-N 50594506 CHEMBL5183218 P2X purinoceptor 3 Homo sapiens <100000 ChEMBL 10.7270/Q2XS60DK 35930402 Isaak, A; Dobelmann, C; Füsser, FT; Erlitz, KS; Koch, O; Junker, A European Institute for Molecular Imaging (EIMI) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50594506 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50594506&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 168278797 482605358 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51473625 Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](OC(=O)c2ccccc2)[C@H]1OC(=O)c1ccccc1 InChI=1S/C24H24N5O15P3/c25-20-17-21(27-12-26-20)29(13-28-17)22-19(42-24(31)15-9-5-2-6-10-15)18(41-23(30)14-7-3-1-4-8-14)16(40-22)11-39-46(35,36)44-47(37,38)43-45(32,33)34/h1-10,12-13,16,18-19,22H,11H2,(H,35,36)(H,37,38)(H2,25,26,27)(H2,32,33,34)/t16-,18-,19-,22-/m1/s1 IKEQMDLYPNVQGH-WGQQHEPDSA-N 50594505 CHEMBL5177316 P2X purinoceptor 3 Homo sapiens <100000 ChEMBL 10.7270/Q2XS60DK 35930402 Isaak, A; Dobelmann, C; Füsser, FT; Erlitz, KS; Koch, O; Junker, A European Institute for Molecular Imaging (EIMI) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50594505 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50594505&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 5311061 482605357 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51473626 COc1ccc(cc1)C(=O)O[C@@H]1[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]([C@@H]1OC(=O)c1ccc(OC)cc1)n1cnc2c(N)ncnc12 InChI=1S/C26H28N5O17P3/c1-41-16-7-3-14(4-8-16)25(32)45-20-18(11-43-50(37,38)48-51(39,40)47-49(34,35)36)44-24(31-13-30-19-22(27)28-12-29-23(19)31)21(20)46-26(33)15-5-9-17(42-2)10-6-15/h3-10,12-13,18,20-21,24H,11H2,1-2H3,(H,37,38)(H,39,40)(H2,27,28,29)(H2,34,35,36)/t18-,20-,21-,24-/m1/s1 RKFOOQRRMNOARS-UMCMBGNQSA-N 50594494 CHEMBL5197509 P2X purinoceptor 3 Homo sapiens <100000 ChEMBL 10.7270/Q2XS60DK 35930402 Isaak, A; Dobelmann, C; Füsser, FT; Erlitz, KS; Koch, O; Junker, A European Institute for Molecular Imaging (EIMI) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50594494 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50594494&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 168284464 482605346 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51473627 Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](OC(=O)c2cccc3ccccc23)[C@H]1OC(=O)c1cccc2ccccc12 InChI=1S/C32H28N5O15P3/c33-28-25-29(35-16-34-28)37(17-36-25)30-27(50-32(39)23-14-6-10-19-8-2-4-12-21(19)23)26(49-31(38)22-13-5-9-18-7-1-3-11-20(18)22)24(48-30)15-47-54(43,44)52-55(45,46)51-53(40,41)42/h1-14,16-17,24,26-27,30H,15H2,(H,43,44)(H,45,46)(H2,33,34,35)(H2,40,41,42)/t24-,26-,27-,30-/m1/s1 PSBROSWEMLTASJ-BQOYKFDPSA-N 50594506 CHEMBL5183218 P2X purinoceptor 3 Homo sapiens 18621 ChEMBL 10.7270/Q2XS60DK 35930402 Isaak, A; Dobelmann, C; Füsser, FT; Erlitz, KS; Koch, O; Junker, A European Institute for Molecular Imaging (EIMI) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50594506 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50594506&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 168278797 482605358 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51474487 CNc1ncnc2n(cnc12)[C@H]1C[C@H](OP(O)(O)=O)[C@@H](COP(O)(O)=O)O1 InChI=1S/C11H17N5O9P2/c1-12-10-9-11(14-4-13-10)16(5-15-9)8-2-6(25-27(20,21)22)7(24-8)3-23-26(17,18)19/h4-8H,2-3H2,1H3,(H,12,13,14)(H2,17,18,19)(H2,20,21,22)/t6-,7+,8+/m0/s1 CCPLITQNIFLYQB-XLPZGREQSA-N 50118229 CHEMBL129841::MRS 2179 P2X purinoceptor 3 Homo sapiens 12900 ChEMBL 10.7270/Q2Q52TMM 34902735 Li, X; Guo, T; Feng, Q; Bai, T; Wu, L; Liu, Y; Zheng, X; Jia, J; Pei, J; Wu, S; Song, Y; Zhang, Y Northwest University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118229 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118229&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 5311303 104011566 CHEMBL129841 ZINC03985980 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370599 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2cnc(NC(C)=O)[nH]2)C1 648608 US20240034729, Compound 1 P2X purinoceptor 3 Homo sapiens >1000 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648608 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648608&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 154965014 494493470 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370600 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(NC(C)=O)cc2F)C1 InChI=1S/C23H24F2N4O4/c1-13-4-5-29-19(11-16-12-28(6-7-33-16)23(31)32-3)22(27-20(29)8-13)21-17(24)9-15(10-18(21)25)26-14(2)30/h4-5,8-10,16H,6-7,11-12H2,1-3H3,(H,26,30)/t16-/m0/s1 ZOCCYLUMAQVNRP-INIZCTEOSA-N 648609 US20240034729, Compound 2 P2X purinoceptor 3 Homo sapiens <10 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648609 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648609&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 153626229 494493471 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370601 COC(=O)Nc1cc(F)c(-c2nc3cc(C)ccn3c2C[C@H]2CN(CCO2)C(=O)OC)c(F)c1 InChI=1S/C23H24F2N4O5/c1-13-4-5-29-18(11-15-12-28(6-7-34-15)23(31)33-3)21(27-19(29)8-13)20-16(24)9-14(10-17(20)25)26-22(30)32-2/h4-5,8-10,15H,6-7,11-12H2,1-3H3,(H,26,30)/t15-/m0/s1 GQNGGGJDDZIQFX-HNNXBMFYSA-N 648610 US20240034729, Compound 3 P2X purinoceptor 3 Homo sapiens <100 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648610 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648610&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 153626306 494493472 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370602 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(cc2F)-c2ccc[nH]2)C1 648611 US20240034729, Compound 4 P2X purinoceptor 3 Homo sapiens <10 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648611 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648611&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 153626443 494493473 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370603 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(cc2F)-n2ccnc2)C1 InChI=1S/C24H23F2N5O3/c1-15-3-5-31-20(12-17-13-29(7-8-34-17)24(32)33-2)23(28-21(31)9-15)22-18(25)10-16(11-19(22)26)30-6-4-27-14-30/h3-6,9-11,14,17H,7-8,12-13H2,1-2H3/t17-/m0/s1 KZIZHQRDEGEWBI-KRWDZBQOSA-N 648612 US20240034729, Compound 5 P2X purinoceptor 3 Homo sapiens <10 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648612 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648612&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 153626492 494493474 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370604 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(cc2F)C#N)C1 InChI=1S/C22H20F2N4O3/c1-13-3-4-28-18(10-15-12-27(5-6-31-15)22(29)30-2)21(26-19(28)7-13)20-16(23)8-14(11-25)9-17(20)24/h3-4,7-9,15H,5-6,10,12H2,1-2H3/t15-/m0/s1 LXVUGJLQCNMXBS-HNNXBMFYSA-N 648613 US20240034729, Compound 6 P2X purinoceptor 3 Homo sapiens <1000 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648613 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648613&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 153626379 494493475 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370605 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(cc2F)-c2ncc[nH]2)C1 648614 US20240034729, Compound 7 P2X purinoceptor 3 Homo sapiens <10 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648614 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648614&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 153626227 494493476 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370606 CNC(=N)c1cc(F)c(-c2nc3cc(C)ccn3c2C[C@H]2CN(CCO2)C(=O)OC)c(F)c1 InChI=1S/C23H25F2N5O3/c1-13-4-5-30-18(11-15-12-29(6-7-33-15)23(31)32-3)21(28-19(30)8-13)20-16(24)9-14(10-17(20)25)22(26)27-2/h4-5,8-10,15H,6-7,11-12H2,1-3H3,(H2,26,27)/t15-/m0/s1 OKSXNDKAHVPANY-HNNXBMFYSA-N 648615 US20240034729, Compound 8 P2X purinoceptor 3 Homo sapiens >1000 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648615 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648615&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 154964993 494493477 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370607 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(cc2F)-c2nccn2C)C1 InChI=1S/C25H25F2N5O3/c1-15-4-6-32-20(13-17-14-31(8-9-35-17)25(33)34-3)23(29-21(32)10-15)22-18(26)11-16(12-19(22)27)24-28-5-7-30(24)2/h4-7,10-12,17H,8-9,13-14H2,1-3H3/t17-/m0/s1 WUUBPIXOTOHBFA-KRWDZBQOSA-N 648616 US20240034729, Compound 9 P2X purinoceptor 3 Homo sapiens >1000 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648616 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648616&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 153626374 494493478 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370608 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(cc2F)-c2ncco2)C1 InChI=1S/C24H22F2N4O4/c1-14-3-5-30-19(12-16-13-29(6-8-33-16)24(31)32-2)22(28-20(30)9-14)21-17(25)10-15(11-18(21)26)23-27-4-7-34-23/h3-5,7,9-11,16H,6,8,12-13H2,1-2H3/t16-/m0/s1 WHMGTJMAQRUFOJ-INIZCTEOSA-N 648617 US20240034729, Compound 10 P2X purinoceptor 3 Homo sapiens <10 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648617 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648617&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 153626278 494493479 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370609 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(cc2F)-c2ccco2)C1 InChI=1S/C25H23F2N3O4/c1-15-5-6-30-20(13-17-14-29(7-9-33-17)25(31)32-2)24(28-22(30)10-15)23-18(26)11-16(12-19(23)27)21-4-3-8-34-21/h3-6,8,10-12,17H,7,9,13-14H2,1-2H3/t17-/m0/s1 OLLFXUXHFAJSSS-KRWDZBQOSA-N 648618 US20240034729, Compound 11 P2X purinoceptor 3 Homo sapiens <100 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648618 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648618&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 153626268 494493480 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370610 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(cc2F)-c2cccs2)C1 InChI=1S/C25H23F2N3O3S/c1-15-5-6-30-20(13-17-14-29(7-8-33-17)25(31)32-2)24(28-22(30)10-15)23-18(26)11-16(12-19(23)27)21-4-3-9-34-21/h3-6,9-12,17H,7-8,13-14H2,1-2H3/t17-/m0/s1 RBWFRFIUXLFXTN-KRWDZBQOSA-N 648619 US20240034729, Compound 12 P2X purinoceptor 3 Homo sapiens <10 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648619 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648619&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 153626259 494493481 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370611 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(cc2F)-c2cccn2C)C1 InChI=1S/C26H26F2N4O3/c1-16-6-8-32-22(14-18-15-31(9-10-35-18)26(33)34-3)25(29-23(32)11-16)24-19(27)12-17(13-20(24)28)21-5-4-7-30(21)2/h4-8,11-13,18H,9-10,14-15H2,1-3H3/t18-/m0/s1 WYEUJCOHCNBYAU-SFHVURJKSA-N 648620 US20240034729, Compound 13 P2X purinoceptor 3 Homo sapiens <100 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648620 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648620&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 153626367 494493482 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370612 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(cc2F)C(C)=O)C1 InChI=1S/C23H23F2N3O4/c1-13-4-5-28-19(11-16-12-27(6-7-32-16)23(30)31-3)22(26-20(28)8-13)21-17(24)9-15(14(2)29)10-18(21)25/h4-5,8-10,16H,6-7,11-12H2,1-3H3/t16-/m0/s1 TVKWZSIQDXTGDG-INIZCTEOSA-N 648621 US20240034729, Compound 14 P2X purinoceptor 3 Homo sapiens >1000 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648621 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648621&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 153626308 494493483 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370613 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(cc2F)-c2cc[nH]n2)C1 648622 US20240034729, Compound 15 P2X purinoceptor 3 Homo sapiens <10 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648622 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648622&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 153626470 494493484 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370614 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(cc2F)-c2ccon2)C1 InChI=1S/C24H22F2N4O4/c1-14-3-5-30-20(12-16-13-29(6-8-33-16)24(31)32-2)23(27-21(30)9-14)22-17(25)10-15(11-18(22)26)19-4-7-34-28-19/h3-5,7,9-11,16H,6,8,12-13H2,1-2H3/t16-/m0/s1 RESJADGMRCTTPH-INIZCTEOSA-N 648623 US20240034729, Compound 16 P2X purinoceptor 3 Homo sapiens <100 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648623 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648623&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 153626375 494493485 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370615 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(cc2F)-c2ccccn2)C1 InChI=1S/C26H24F2N4O3/c1-16-6-8-32-22(14-18-15-31(9-10-35-18)26(33)34-2)25(30-23(32)11-16)24-19(27)12-17(13-20(24)28)21-5-3-4-7-29-21/h3-8,11-13,18H,9-10,14-15H2,1-2H3/t18-/m0/s1 GUHYBOUQRXHRKK-SFHVURJKSA-N 648624 US20240034729, Compound 17 P2X purinoceptor 3 Homo sapiens <100 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648624 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648624&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 153626447 494493486 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370616 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(cc2F)-c2ncccn2)C1 InChI=1S/C25H23F2N5O3/c1-15-4-7-32-20(13-17-14-31(8-9-35-17)25(33)34-2)23(30-21(32)10-15)22-18(26)11-16(12-19(22)27)24-28-5-3-6-29-24/h3-7,10-12,17H,8-9,13-14H2,1-2H3/t17-/m0/s1 GFDVGVRALFHLCS-KRWDZBQOSA-N 648625 US20240034729, Compound 18 P2X purinoceptor 3 Homo sapiens <1000 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648625 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648625&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 166774958 494493487 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370617 CNC(=O)c1cc(F)c(-c2nc3cc(C)ccn3c2CC(N)=O)c(F)c1 InChI=1S/C18H16F2N4O2/c1-9-3-4-24-13(8-14(21)25)17(23-15(24)5-9)16-11(19)6-10(7-12(16)20)18(26)22-2/h3-7H,8H2,1-2H3,(H2,21,25)(H,22,26) JEVNCGWTOXVFKN-UHFFFAOYSA-N 648626 US20240034729, Compound 19 P2X purinoceptor 3 Homo sapiens >1000 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648626 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648626&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 154965000 494493488 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370618 CCOC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)C(=O)Nc2cc(F)cc(F)c2)C1 InChI=1S/C23H24F2N4O4/c1-3-32-23(31)28-6-7-33-18(13-28)12-19-21(27-20-8-14(2)4-5-29(19)20)22(30)26-17-10-15(24)9-16(25)11-17/h4-5,8-11,18H,3,6-7,12-13H2,1-2H3,(H,26,30)/t18-/m0/s1 AFBJKCROWCJWRA-SFHVURJKSA-N 648627 US20240034729, Compound 20 P2X purinoceptor 3 Homo sapiens >1000 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648627 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648627&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 154964997 494493489 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370619 CNC(=O)c1ccc(s1)-c1nc2cc(C)ccn2c1C[C@H]1CN(CCO1)C(=O)OC InChI=1S/C21H24N4O4S/c1-13-6-7-25-15(11-14-12-24(8-9-29-14)21(27)28-3)19(23-18(25)10-13)16-4-5-17(30-16)20(26)22-2/h4-7,10,14H,8-9,11-12H2,1-3H3,(H,22,26)/t14-/m0/s1 NGIBGKCESBVZJA-AWEZNQCLSA-N 648628 US20240034729, Compound 21 P2X purinoceptor 3 Homo sapiens >1000 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648628 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648628&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 153626297 494493490 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370620 CNC(=O)c1coc(c1F)-c1nc2cc(C)ccn2c1C[C@H]1CN(CCO1)C(=O)OC InChI=1S/C21H23FN4O5/c1-12-4-5-26-15(9-13-10-25(6-7-30-13)21(28)29-3)18(24-16(26)8-12)19-17(22)14(11-31-19)20(27)23-2/h4-5,8,11,13H,6-7,9-10H2,1-3H3,(H,23,27)/t13-/m0/s1 QAMJHBGPDDIUCX-ZDUSSCGKSA-N 648629 US20240034729, Compound 22 P2X purinoceptor 3 Homo sapiens >1000 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648629 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648629&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 171362254 494493491 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370621 CNC(=O)c1csc(c1F)-c1nc2cc(C)ccn2c1C[C@H]1CN(CCO1)C(=O)OC InChI=1S/C21H23FN4O4S/c1-12-4-5-26-15(9-13-10-25(6-7-30-13)21(28)29-3)18(24-16(26)8-12)19-17(22)14(11-31-19)20(27)23-2/h4-5,8,11,13H,6-7,9-10H2,1-3H3,(H,23,27)/t13-/m0/s1 QVMKFDULZHLNOT-ZDUSSCGKSA-N 648630 US20240034729, Compound 23 P2X purinoceptor 3 Homo sapiens >1000 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648630 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648630&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 171362255 494493492 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370622 CNC(=O)c1c[nH]c(c1F)-c1nc2cc(C)ccn2c1C[C@H]1CN(CCO1)C(=O)OC 648631 US20240034729, Compound 24 P2X purinoceptor 3 Homo sapiens >1000 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648631 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648631&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 153626385 494493493 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370623 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(NC(=O)CCC(O)=O)cc2F)C1 InChI=1S/C25H26F2N4O6/c1-14-5-6-31-19(12-16-13-30(7-8-37-16)25(35)36-2)24(29-20(31)9-14)23-17(26)10-15(11-18(23)27)28-21(32)3-4-22(33)34/h5-6,9-11,16H,3-4,7-8,12-13H2,1-2H3,(H,28,32)(H,33,34)/t16-/m0/s1 IGXSAWUYSOWKEY-INIZCTEOSA-N 648632 US20240034729, Compound 25 P2X purinoceptor 3 Homo sapiens <10 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648632 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648632&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 153626366 494493494 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370624 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(cc2F)N2C(=O)C=CC2=O)C1 InChI=1S/C25H22F2N4O5/c1-14-5-6-30-19(12-16-13-29(7-8-36-16)25(34)35-2)24(28-20(30)9-14)23-17(26)10-15(11-18(23)27)31-21(32)3-4-22(31)33/h3-6,9-11,16H,7-8,12-13H2,1-2H3/t16-/m0/s1 FNUMVDMQAAPMOA-INIZCTEOSA-N 648633 US20240034729, Compound 26::US20240034729, Compound 28 P2X purinoceptor 3 Homo sapiens <1000 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648633 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648633&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 153626238 494493495 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370625 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(NC(=O)\C=C\C(O)=O)cc2F)C1 InChI=1S/C25H24F2N4O6/c1-14-5-6-31-19(12-16-13-30(7-8-37-16)25(35)36-2)24(29-20(31)9-14)23-17(26)10-15(11-18(23)27)28-21(32)3-4-22(33)34/h3-6,9-11,16H,7-8,12-13H2,1-2H3,(H,28,32)(H,33,34)/b4-3+/t16-/m0/s1 KDKWFHQQAHXGCM-CWDCEQMOSA-N 648634 US20240034729, Compound 27 P2X purinoceptor 3 Homo sapiens <10 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648634 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648634&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 154963302 494493496 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370626 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(cc2F)N2C(=O)C=CC2=O)C1 InChI=1S/C25H22F2N4O5/c1-14-5-6-30-19(12-16-13-29(7-8-36-16)25(34)35-2)24(28-20(30)9-14)23-17(26)10-15(11-18(23)27)31-21(32)3-4-22(31)33/h3-6,9-11,16H,7-8,12-13H2,1-2H3/t16-/m0/s1 FNUMVDMQAAPMOA-INIZCTEOSA-N 648633 US20240034729, Compound 26::US20240034729, Compound 28 P2X purinoceptor 3 Homo sapiens <100 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648633 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648633&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 153626238 494493495 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370627 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(NC(=O)\C=C\C(N)=O)cc2F)C1 InChI=1S/C25H25F2N5O5/c1-14-5-6-32-19(12-16-13-31(7-8-37-16)25(35)36-2)24(30-21(32)9-14)23-17(26)10-15(11-18(23)27)29-22(34)4-3-20(28)33/h3-6,9-11,16H,7-8,12-13H2,1-2H3,(H2,28,33)(H,29,34)/b4-3+/t16-/m0/s1 CBZYLPYGXFUOJC-CWDCEQMOSA-N 648636 US20240034729, Compound 29 P2X purinoceptor 3 Homo sapiens <10 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648636 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648636&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 154965081 494493497 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370628 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)C2CCN(CC2)C(C)=O)C1 InChI=1S/C22H30N4O4/c1-15-4-9-26-19(13-18-14-25(10-11-30-18)22(28)29-3)21(23-20(26)12-15)17-5-7-24(8-6-17)16(2)27/h4,9,12,17-18H,5-8,10-11,13-14H2,1-3H3/t18-/m0/s1 QYPDREQMEHZUIL-SFHVURJKSA-N 648637 US20240034729, Compound 30 P2X purinoceptor 3 Homo sapiens <100 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648637 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648637&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 153626279 494493498 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370629 CNC(=O)c1cc(F)c(-c2nc3cc(C)ccn3c2CN2CCNC(=O)C2)c(F)c1 InChI=1S/C21H21F2N5O2/c1-12-3-5-28-16(10-27-6-4-25-18(29)11-27)20(26-17(28)7-12)19-14(22)8-13(9-15(19)23)21(30)24-2/h3,5,7-9H,4,6,10-11H2,1-2H3,(H,24,30)(H,25,29) NDQXJEWAYVVNTM-UHFFFAOYSA-N 648638 US20240034729, Compound 31 P2X purinoceptor 3 Homo sapiens >1000 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648638 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648638&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 154964998 494493499 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370630 CNC(=O)c1cc(F)c(-c2nc3cc(C)ccn3c2CN2CCN(CC2)C(=O)OC)c(F)c1 InChI=1S/C23H25F2N5O3/c1-14-4-5-30-18(13-28-6-8-29(9-7-28)23(32)33-3)21(27-19(30)10-14)20-16(24)11-15(12-17(20)25)22(31)26-2/h4-5,10-12H,6-9,13H2,1-3H3,(H,26,31) CYVHQUCJLYCNCM-UHFFFAOYSA-N 648639 US20240034729, Compound 32 P2X purinoceptor 3 Homo sapiens >1000 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648639 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648639&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 154965326 494493500 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370631 CNC(=O)c1cc(F)c(-c2nc3cc(C)ccn3c2CN2CCOCC2)c(F)c1 InChI=1S/C21H22F2N4O2/c1-13-3-4-27-17(12-26-5-7-29-8-6-26)20(25-18(27)9-13)19-15(22)10-14(11-16(19)23)21(28)24-2/h3-4,9-11H,5-8,12H2,1-2H3,(H,24,28) XUYLUESUKLCXOH-UHFFFAOYSA-N 648640 US20240034729, Compound 33 P2X purinoceptor 3 Homo sapiens >1000 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648640 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648640&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 154965001 494493501 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370632 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(cc2F)-c2nc(Cl)c[nH]2)C1 648641 US20240034729, Compound 34 P2X purinoceptor 3 Homo sapiens <10 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648641 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648641&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 153626400 494493502 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370633 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(O)cc2F)C1 InChI=1S/C21H21F2N3O4/c1-12-3-4-26-17(10-14-11-25(5-6-30-14)21(28)29-2)20(24-18(26)7-12)19-15(22)8-13(27)9-16(19)23/h3-4,7-9,14,27H,5-6,10-11H2,1-2H3/t14-/m0/s1 MVHMPKLPQTZARP-AWEZNQCLSA-N 648642 US20240034729, Compound 35 P2X purinoceptor 3 Homo sapiens >1000 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648642 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648642&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 153626247 494493503 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370634 CNC(=O)Oc1cc(F)c(-c2nc3cc(C)ccn3c2C[C@H]2CN(CCO2)C(=O)OC)c(F)c1 InChI=1S/C23H24F2N4O5/c1-13-4-5-29-18(11-15-12-28(6-7-33-15)23(31)32-3)21(27-19(29)8-13)20-16(24)9-14(10-17(20)25)34-22(30)26-2/h4-5,8-10,15H,6-7,11-12H2,1-3H3,(H,26,30)/t15-/m0/s1 VVNKCYWPQPAEDD-HNNXBMFYSA-N 648643 US20240034729, Compound 36 P2X purinoceptor 3 Homo sapiens <100 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648643 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648643&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 153626479 494493504 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370635 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(cc2F)-c2nc(c[nH]2)C(F)(F)F)C1 648644 US20240034729, Compound 37 P2X purinoceptor 3 Homo sapiens <10 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648644 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648644&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 153626295 494493505 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370636 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(cc2F)-c2nc(c[nH]2)C#N)C1 648645 US20240034729, Compound 38 P2X purinoceptor 3 Homo sapiens <10 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648645 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648645&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 153626452 494493506 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370637 CNC(=O)c1cc(F)c(-c2[nH]c3cc(C)ccc3c2C[C@H]2CN(CCO2)C(=O)OC)c(F)c1 648646 US20240034729, Compound 39 P2X purinoceptor 3 Homo sapiens >1000 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648646 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648646&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 154964972 494493507 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370638 CNC(=O)c1cc(F)c(-c2cc3cc(C)ccc3n2C[C@H]2CN(CCO2)C(=O)OC)c(F)c1 InChI=1S/C24H25F2N3O4/c1-14-4-5-20-15(8-14)11-21(22-18(25)9-16(10-19(22)26)23(30)27-2)29(20)13-17-12-28(6-7-33-17)24(31)32-3/h4-5,8-11,17H,6-7,12-13H2,1-3H3,(H,27,30)/t17-/m1/s1 ZINIRHXGYOJNML-QGZVFWFLSA-N 648647 US20240034729, Compound 40 P2X purinoceptor 3 Homo sapiens >1000 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648647 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648647&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 153626421 494493508 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370639 CNC(=O)c1cc(F)c(C2=CC3C=C(C)C=CN3N2C[C@H]2CN(CCO2)C(=O)OC)c(F)c1 InChI=1S/C23H26F2N4O4/c1-14-4-5-28-16(8-14)11-20(21-18(24)9-15(10-19(21)25)22(30)26-2)29(28)13-17-12-27(6-7-33-17)23(31)32-3/h4-5,8-11,16-17H,6-7,12-13H2,1-3H3,(H,26,30)/t16?,17-/m1/s1 NTFISYSUDDHVGP-ZYMOGRSISA-N 648648 US20240034729, Compound 41 P2X purinoceptor 3 Homo sapiens >1000 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648648 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648648&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 167370646 494493509 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370640 CNC(=O)c1cc(F)c(-c2nc3cc(C)ncn3c2C[C@H]2CN(CCO2)C(=O)OC)c(F)c1 InChI=1S/C22H23F2N5O4/c1-12-6-18-27-20(19-15(23)7-13(8-16(19)24)21(30)25-2)17(29(18)11-26-12)9-14-10-28(4-5-33-14)22(31)32-3/h6-8,11,14H,4-5,9-10H2,1-3H3,(H,25,30)/t14-/m0/s1 KVJLJFKPFHGJIT-AWEZNQCLSA-N 648649 US20240034729, Compound 42 P2X purinoceptor 3 Homo sapiens <10 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648649 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648649&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 153626396 494493510 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370641 CNS(=O)(=O)c1cc(F)c(-c2nc3cc(C)ccn3c2C[C@H]2CN(CCO2)C(=O)OC)c(F)c1 InChI=1S/C22H24F2N4O5S/c1-13-4-5-28-18(9-14-12-27(6-7-33-14)22(29)32-3)21(26-19(28)8-13)20-16(23)10-15(11-17(20)24)34(30,31)25-2/h4-5,8,10-11,14,25H,6-7,9,12H2,1-3H3/t14-/m0/s1 ZPFZDNIGCDBENI-AWEZNQCLSA-N 648650 US20240034729, Compound 43 P2X purinoceptor 3 Homo sapiens <10 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648650 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648650&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 153626456 494493511 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370642 CNC(=O)c1cc(F)c(-c2nc3CC(C)CCn3c2C[C@H]2CN(CCO2)C(=O)OC)c(F)c1 InChI=1S/C23H28F2N4O4/c1-13-4-5-29-18(11-15-12-28(6-7-33-15)23(31)32-3)21(27-19(29)8-13)20-16(24)9-14(10-17(20)25)22(30)26-2/h9-10,13,15H,4-8,11-12H2,1-3H3,(H,26,30)/t13?,15-/m0/s1 SDEVIXYKWAQQKQ-WUJWULDRSA-N 648651 US20240034729, Compound 44 P2X purinoceptor 3 Homo sapiens <10 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648651 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648651&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 153626246 494493512 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370643 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(cc2F)N2CCN(C)CC2=O)C1 InChI=1S/C26H29F2N5O4/c1-16-4-5-33-21(13-18-14-31(8-9-37-18)26(35)36-3)25(29-22(33)10-16)24-19(27)11-17(12-20(24)28)32-7-6-30(2)15-23(32)34/h4-5,10-12,18H,6-9,13-15H2,1-3H3/t18-/m0/s1 WQLPLRBPJKRFIR-SFHVURJKSA-N 648652 US20240034729, Compound 45 P2X purinoceptor 3 Homo sapiens >1000 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648652 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648652&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 153626276 494493513 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370644 CNC(=O)c1cc(F)c(-c2nc3cc(C)ccn3c2C[C@H]2CN(CCN2)C(=O)OC)c(F)c1 InChI=1S/C23H25F2N5O3/c1-13-4-6-30-18(11-15-12-29(7-5-27-15)23(32)33-3)21(28-19(30)8-13)20-16(24)9-14(10-17(20)25)22(31)26-2/h4,6,8-10,15,27H,5,7,11-12H2,1-3H3,(H,26,31)/t15-/m0/s1 QWULRINIELDPMA-HNNXBMFYSA-N 648653 US20240034729, Compound 46 P2X purinoceptor 3 Homo sapiens >1000 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648653 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648653&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 153626277 494493514 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370645 CNC(=O)c1cc(F)c(-c2nc3cc(C)ccn3c2CN2CCOCC2=O)c(F)c1 InChI=1S/C21H20F2N4O3/c1-12-3-4-27-16(10-26-5-6-30-11-18(26)28)20(25-17(27)7-12)19-14(22)8-13(9-15(19)23)21(29)24-2/h3-4,7-9H,5-6,10-11H2,1-2H3,(H,24,29) FSIHXUQFLKLSDB-UHFFFAOYSA-N 648654 US20240034729, Compound 47 P2X purinoceptor 3 Homo sapiens >1000 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648654 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648654&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 153626363 494493515 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370646 CNC(=O)c1cc(F)c(-c2nc3cc(C)ccn3c2CN2CCNCC2=O)c(F)c1 InChI=1S/C21H21F2N5O2/c1-12-3-5-28-16(11-27-6-4-25-10-18(27)29)20(26-17(28)7-12)19-14(22)8-13(9-15(19)23)21(30)24-2/h3,5,7-9,25H,4,6,10-11H2,1-2H3,(H,24,30) RRDRWCPDUILYPE-UHFFFAOYSA-N 648655 US20240034729, Compound 48 P2X purinoceptor 3 Homo sapiens <1000 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648655 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648655&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 154964973 494493516 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370647 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(cc2F)C(=O)OC)C1 InChI=1S/C23H23F2N3O5/c1-13-4-5-28-18(11-15-12-27(6-7-33-15)23(30)32-3)21(26-19(28)8-13)20-16(24)9-14(10-17(20)25)22(29)31-2/h4-5,8-10,15H,6-7,11-12H2,1-3H3/t15-/m0/s1 SKLWZPMIHYBSHC-HNNXBMFYSA-N 648656 US20240034729, Compound 49 P2X purinoceptor 3 Homo sapiens <10 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648656 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648656&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 154965025 494493517 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370648 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(cc2F)-n2cccn2)C1 InChI=1S/C24H23F2N5O3/c1-15-4-7-30-20(13-17-14-29(8-9-34-17)24(32)33-2)23(28-21(30)10-15)22-18(25)11-16(12-19(22)26)31-6-3-5-27-31/h3-7,10-12,17H,8-9,13-14H2,1-2H3/t17-/m0/s1 AGUZWYXHAMTYQS-KRWDZBQOSA-N 648657 US20240034729, Compound 50 P2X purinoceptor 3 Homo sapiens <10 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648657 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648657&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 154965084 494493518 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370649 CCOC(=O)c1cn(cn1)-c1cc(F)c(-c2nc3cc(C)ccn3c2C[C@H]2CN(CCO2)C(=O)OC)c(F)c1 InChI=1S/C27H27F2N5O5/c1-4-38-26(35)21-14-33(15-30-21)17-10-19(28)24(20(29)11-17)25-22(34-6-5-16(2)9-23(34)31-25)12-18-13-32(7-8-39-18)27(36)37-3/h5-6,9-11,14-15,18H,4,7-8,12-13H2,1-3H3/t18-/m0/s1 MXIMIFGDDKEXFY-SFHVURJKSA-N 648658 US20240034729, Compound 51 P2X purinoceptor 3 Homo sapiens <1000 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648658 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648658&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 154965110 494493519 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370650 CCC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(cc2F)-c2ncc[nH]2)C1 648659 US20240034729, Compound 52 P2X purinoceptor 3 Homo sapiens <10 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648659 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648659&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 154965029 494493520 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370651 CNC(=O)c1cc(F)c(-c2oc3cc(C)ccc3c2C[C@H]2CN(CCO2)C(=O)OC)c(F)c1 InChI=1S/C24H24F2N2O5/c1-13-4-5-16-17(11-15-12-28(6-7-32-15)24(30)31-3)22(33-20(16)8-13)21-18(25)9-14(10-19(21)26)23(29)27-2/h4-5,8-10,15H,6-7,11-12H2,1-3H3,(H,27,29)/t15-/m0/s1 CMGRYWJXSRSASL-HNNXBMFYSA-N 648660 US20240034729, Compound 53 P2X purinoceptor 3 Homo sapiens <10 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648660 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648660&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 153626333 494493521 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370652 CNC(=O)c1cc(F)c(-c2oc3cc(C)cnc3c2C[C@H]2CN(CCO2)C(=O)OC)c(F)c1 InChI=1S/C23H23F2N3O5/c1-12-6-18-20(27-10-12)15(9-14-11-28(4-5-32-14)23(30)31-3)21(33-18)19-16(24)7-13(8-17(19)25)22(29)26-2/h6-8,10,14H,4-5,9,11H2,1-3H3,(H,26,29)/t14-/m0/s1 RKPLJPWAKOSLTD-AWEZNQCLSA-N 648661 US20240034729, Compound 54 P2X purinoceptor 3 Homo sapiens <10 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648661 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648661&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 153626240 494493522 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370653 CNC(=O)c1cc(F)c(-c2oc3cc(C)ncc3c2C[C@H]2CN(CCO2)C(=O)OC)c(F)c1 InChI=1S/C23H23F2N3O5/c1-12-6-19-16(10-27-12)15(9-14-11-28(4-5-32-14)23(30)31-3)21(33-19)20-17(24)7-13(8-18(20)25)22(29)26-2/h6-8,10,14H,4-5,9,11H2,1-3H3,(H,26,29)/t14-/m0/s1 ZUMLWRNEEVMBGN-AWEZNQCLSA-N 648662 US20240034729, Compound 55 P2X purinoceptor 3 Homo sapiens <10 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648662 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648662&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 153626230 494493523 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370654 CNC(=O)c1cc(F)c(-c2oc3nc(C)ccc3c2C[C@H]2CN(CCO2)C(=O)OC)c(F)c1 InChI=1S/C23H23F2N3O5/c1-12-4-5-15-16(10-14-11-28(6-7-32-14)23(30)31-3)20(33-22(15)27-12)19-17(24)8-13(9-18(19)25)21(29)26-2/h4-5,8-9,14H,6-7,10-11H2,1-3H3,(H,26,29)/t14-/m0/s1 ZKGGQZGDMTVMTA-AWEZNQCLSA-N 648663 US20240034729, Compound 56 P2X purinoceptor 3 Homo sapiens <10 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648663 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648663&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 153626395 494493524 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370655 CNC(=O)c1cc(F)c(-c2nn3cc(C)ccc3c2C[C@H]2CN(CCO2)C(=O)OC)c(F)c1 InChI=1S/C23H24F2N4O4/c1-13-4-5-19-16(10-15-12-28(6-7-33-15)23(31)32-3)21(27-29(19)11-13)20-17(24)8-14(9-18(20)25)22(30)26-2/h4-5,8-9,11,15H,6-7,10,12H2,1-3H3,(H,26,30)/t15-/m0/s1 SLMKFBOXUYFACX-HNNXBMFYSA-N 648664 US20240034729, Compound 57 P2X purinoceptor 3 Homo sapiens <10 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648664 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648664&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 167370687 494493525 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370656 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(cc2F)-n2cnnn2)C1 InChI=1S/C22H21F2N7O3/c1-13-3-4-30-18(10-15-11-29(5-6-34-15)22(32)33-2)21(26-19(30)7-13)20-16(23)8-14(9-17(20)24)31-12-25-27-28-31/h3-4,7-9,12,15H,5-6,10-11H2,1-2H3/t15-/m0/s1 KYNGHRJFKXXFMM-HNNXBMFYSA-N 648665 US20240034729, Compound 58 P2X purinoceptor 3 Homo sapiens <10 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648665 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648665&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 154965030 494493526 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370657 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(cc2F)-c2nc(c[nH]2)C2(CC2)C(O)=O)C1 648666 US20240034729, Compound 59 P2X purinoceptor 3 Homo sapiens <10 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648666 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648666&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 153626250 494493527 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370658 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(NC(=O)C3(CC3)C(O)=O)cc2F)C1 InChI=1S/C26H26F2N4O6/c1-14-3-6-32-19(12-16-13-31(7-8-38-16)25(36)37-2)22(30-20(32)9-14)21-17(27)10-15(11-18(21)28)29-23(33)26(4-5-26)24(34)35/h3,6,9-11,16H,4-5,7-8,12-13H2,1-2H3,(H,29,33)(H,34,35)/t16-/m0/s1 XMIDZVLJVFPQBM-INIZCTEOSA-N 648667 US20240034729, Compound 60 P2X purinoceptor 3 Homo sapiens <10 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648667 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648667&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 154965031 494493528 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370659 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(NC(=O)CC3(CC3)C(O)=O)cc2F)C1 InChI=1S/C27H28F2N4O6/c1-15-3-6-33-20(12-17-14-32(7-8-39-17)26(37)38-2)24(31-21(33)9-15)23-18(28)10-16(11-19(23)29)30-22(34)13-27(4-5-27)25(35)36/h3,6,9-11,17H,4-5,7-8,12-14H2,1-2H3,(H,30,34)(H,35,36)/t17-/m0/s1 ZVTRDKXXIBGNKX-KRWDZBQOSA-N 648668 US20240034729, Compound 61 P2X purinoceptor 3 Homo sapiens <10 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648668 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648668&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 154965028 494493529 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370660 CNC(=O)c1cc(F)c(-c2nc3CN(C)CCn3c2C[C@H]2CN(CCO2)C(=O)OC)c(F)c1 InChI=1S/C22H27F2N5O4/c1-25-21(30)13-8-15(23)19(16(24)9-13)20-17(29-5-4-27(2)12-18(29)26-20)10-14-11-28(6-7-33-14)22(31)32-3/h8-9,14H,4-7,10-12H2,1-3H3,(H,25,30)/t14-/m0/s1 BHHWAMHRTZJUAF-AWEZNQCLSA-N 648669 US20240034729, Compound 62 P2X purinoceptor 3 Homo sapiens >1000 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648669 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648669&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 167370656 494493530 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370661 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(CC(N)=O)cc2F)C1 InChI=1S/C23H24F2N4O4/c1-13-3-4-29-18(11-15-12-28(5-6-33-15)23(31)32-2)22(27-20(29)7-13)21-16(24)8-14(9-17(21)25)10-19(26)30/h3-4,7-9,15H,5-6,10-12H2,1-2H3,(H2,26,30)/t15-/m0/s1 BUTKGCPIORQPJL-HNNXBMFYSA-N 648670 US20240034729, Compound 63 P2X purinoceptor 3 Homo sapiens <1000 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648670 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648670&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 154965027 494493531 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370662 CNC(=O)Cc1cc(F)c(-c2nc3cc(C)ccn3c2C[C@H]2CN(CCO2)C(=O)OC)c(F)c1 InChI=1S/C24H26F2N4O4/c1-14-4-5-30-19(12-16-13-29(6-7-34-16)24(32)33-3)23(28-20(30)8-14)22-17(25)9-15(10-18(22)26)11-21(31)27-2/h4-5,8-10,16H,6-7,11-13H2,1-3H3,(H,27,31)/t16-/m0/s1 AHLQWAHOPDFBBQ-INIZCTEOSA-N 648671 US20240034729, Compound 64 P2X purinoceptor 3 Homo sapiens <1000 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648671 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648671&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 153626251 494493532 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370663 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(cc2F)C2(CC2)C(N)=O)C1 InChI=1S/C25H26F2N4O4/c1-14-3-6-31-19(12-16-13-30(7-8-35-16)24(33)34-2)22(29-20(31)9-14)21-17(26)10-15(11-18(21)27)25(4-5-25)23(28)32/h3,6,9-11,16H,4-5,7-8,12-13H2,1-2H3,(H2,28,32)/t16-/m0/s1 DZLGTZYOCSFHPE-INIZCTEOSA-N 648672 US20240034729, Compound 65 P2X purinoceptor 3 Homo sapiens <1000 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648672 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648672&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 154965123 494493533 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370664 CNC(=O)C1(CC1)c1cc(F)c(-c2nc3cc(C)ccn3c2C[C@H]2CN(CCO2)C(=O)OC)c(F)c1 InChI=1S/C26H28F2N4O4/c1-15-4-7-32-20(13-17-14-31(8-9-36-17)25(34)35-3)23(30-21(32)10-15)22-18(27)11-16(12-19(22)28)26(5-6-26)24(33)29-2/h4,7,10-12,17H,5-6,8-9,13-14H2,1-3H3,(H,29,33)/t17-/m0/s1 PXVHXILXGIMMKT-KRWDZBQOSA-N 648673 US20240034729, Compound 66 P2X purinoceptor 3 Homo sapiens <1000 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648673&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 166774826 494493534 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370665 CNC1(CC1)c1cc(F)c(-c2nc3cc(C)ccn3c2C[C@H]2CN(CCO2)C(=O)OC)c(F)c1 InChI=1S/C25H28F2N4O3/c1-15-4-7-31-20(13-17-14-30(8-9-34-17)24(32)33-3)23(29-21(31)10-15)22-18(26)11-16(12-19(22)27)25(28-2)5-6-25/h4,7,10-12,17,28H,5-6,8-9,13-14H2,1-3H3/t17-/m0/s1 POZALEDQRFECAB-KRWDZBQOSA-N 648674 US20240034729, Compound 67 P2X purinoceptor 3 Homo sapiens <100 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648674 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648674&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 153626402 494493535 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370666 CNC(c1cc(F)c(-c2nc3cc(C)ccn3c2C[C@H]2CN(CCO2)C(=O)OC)c(F)c1)C(F)(F)F InChI=1S/C24H25F5N4O3/c1-13-4-5-33-18(11-15-12-32(6-7-36-15)23(34)35-3)21(31-19(33)8-13)20-16(25)9-14(10-17(20)26)22(30-2)24(27,28)29/h4-5,8-10,15,22,30H,6-7,11-12H2,1-3H3/t15-,22?/m0/s1 MNGRBCVFEMHDHX-UEDXYCIISA-N 648675 US20240034729, Compound 68 P2X purinoceptor 3 Homo sapiens <100 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648675 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648675&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 153626453 494493536 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370667 CNC1(COC1)c1cc(F)c(-c2nc3cc(C)ccn3c2C[C@H]2CN(CCO2)C(=O)OC)c(F)c1 InChI=1S/C25H28F2N4O4/c1-15-4-5-31-20(11-17-12-30(6-7-35-17)24(32)33-3)23(29-21(31)8-15)22-18(26)9-16(10-19(22)27)25(28-2)13-34-14-25/h4-5,8-10,17,28H,6-7,11-14H2,1-3H3/t17-/m0/s1 UDKNEDCQRLBIKH-KRWDZBQOSA-N 648676 US20240034729, Compound 69 P2X purinoceptor 3 Homo sapiens <100 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648676 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648676&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 153626464 494493537 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370668 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(cc2F)C2(N)COC2)C1 InChI=1S/C24H26F2N4O4/c1-14-3-4-30-19(10-16-11-29(5-6-34-16)23(31)32-2)22(28-20(30)7-14)21-17(25)8-15(9-18(21)26)24(27)12-33-13-24/h3-4,7-9,16H,5-6,10-13,27H2,1-2H3/t16-/m0/s1 VTHFVMOGKUQYNR-INIZCTEOSA-N 648677 US20240034729, Compound 70 P2X purinoceptor 3 Homo sapiens <100 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648677 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648677&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 167370655 494493538 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370669 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(NC3COC3)cc2F)C1 InChI=1S/C24H26F2N4O4/c1-14-3-4-30-20(10-17-11-29(5-6-34-17)24(31)32-2)23(28-21(30)7-14)22-18(25)8-15(9-19(22)26)27-16-12-33-13-16/h3-4,7-9,16-17,27H,5-6,10-13H2,1-2H3/t17-/m0/s1 DCUYRYHPHZGQFN-KRWDZBQOSA-N 648678 US20240034729, Compound 71 P2X purinoceptor 3 Homo sapiens <10 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648678 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648678&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 153626233 494493539 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370670 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(Nc3ccc(Cl)o3)cc2F)C1 InChI=1S/C25H23ClF2N4O4/c1-14-5-6-32-19(12-16-13-31(7-8-35-16)25(33)34-2)24(30-21(32)9-14)23-17(27)10-15(11-18(23)28)29-22-4-3-20(26)36-22/h3-6,9-11,16,29H,7-8,12-13H2,1-2H3/t16-/m0/s1 DIUUTMORUWVAMW-INIZCTEOSA-N 648679 US20240034729, Compound 72 P2X purinoceptor 3 Homo sapiens <1000 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648679 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648679&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 154965371 494493540 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370671 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(Nc3ccc(F)o3)cc2F)C1 InChI=1S/C25H23F3N4O4/c1-14-5-6-32-19(12-16-13-31(7-8-35-16)25(33)34-2)24(30-21(32)9-14)23-17(26)10-15(11-18(23)27)29-22-4-3-20(28)36-22/h3-6,9-11,16,29H,7-8,12-13H2,1-2H3/t16-/m0/s1 ZCWBYRCRTMHZDB-INIZCTEOSA-N 648680 US20240034729, Compound 73 P2X purinoceptor 3 Homo sapiens <1000 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648680 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648680&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 154965121 494493541 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370672 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(Nc3ccco3)cc2F)C1 InChI=1S/C25H24F2N4O4/c1-15-5-6-31-20(13-17-14-30(7-9-34-17)25(32)33-2)24(29-21(31)10-15)23-18(26)11-16(12-19(23)27)28-22-4-3-8-35-22/h3-6,8,10-12,17,28H,7,9,13-14H2,1-2H3/t17-/m0/s1 YAWFZOHWZAGTSE-KRWDZBQOSA-N 648681 US20240034729, Compound 74 P2X purinoceptor 3 Homo sapiens <1000 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648681 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648681&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 154965122 494493542 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370673 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(NC3CCOC3)cc2F)C1 InChI=1S/C25H28F2N4O4/c1-15-3-5-31-21(12-18-13-30(6-8-35-18)25(32)33-2)24(29-22(31)9-15)23-19(26)10-17(11-20(23)27)28-16-4-7-34-14-16/h3,5,9-11,16,18,28H,4,6-8,12-14H2,1-2H3/t16?,18-/m0/s1 SOVHJEJNAQWIKE-DAFXYXGESA-N 648682 US20240034729, Compound 75 P2X purinoceptor 3 Homo sapiens <100 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648682 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648682&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 154965124 494493543 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370674 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(NC3CCOCC3)cc2F)C1 InChI=1S/C26H30F2N4O4/c1-16-3-6-32-22(14-19-15-31(7-10-36-19)26(33)34-2)25(30-23(32)11-16)24-20(27)12-18(13-21(24)28)29-17-4-8-35-9-5-17/h3,6,11-13,17,19,29H,4-5,7-10,14-15H2,1-2H3/t19-/m0/s1 YACIZQAVTVZSDR-IBGZPJMESA-N 648683 US20240034729, Compound 76 P2X purinoceptor 3 Homo sapiens <1000 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648683 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648683&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 153626329 494493544 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370675 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(NCCCC(N)=O)cc2F)C1 InChI=1S/C25H29F2N5O4/c1-15-5-7-32-20(13-17-14-31(8-9-36-17)25(34)35-2)24(30-22(32)10-15)23-18(26)11-16(12-19(23)27)29-6-3-4-21(28)33/h5,7,10-12,17,29H,3-4,6,8-9,13-14H2,1-2H3,(H2,28,33)/t17-/m0/s1 UMPIMVOVJNZHHQ-KRWDZBQOSA-N 648684 US20240034729, Compound 77 P2X purinoceptor 3 Homo sapiens <10 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648684 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648684&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 154965280 494493545 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370676 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(NC3CC(=O)C3)cc2F)C1 InChI=1S/C25H26F2N4O4/c1-14-3-4-31-21(12-18-13-30(5-6-35-18)25(33)34-2)24(29-22(31)7-14)23-19(26)10-16(11-20(23)27)28-15-8-17(32)9-15/h3-4,7,10-11,15,18,28H,5-6,8-9,12-13H2,1-2H3/t18-/m0/s1 MPMWFWFSACAGEC-SFHVURJKSA-N 648685 US20240034729, Compound 78 P2X purinoceptor 3 Homo sapiens <100 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648685 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648685&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 154965208 494493546 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370677 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(NC3CCC(=O)C3)cc2F)C1 InChI=1S/C26H28F2N4O4/c1-15-5-6-32-22(13-19-14-31(7-8-36-19)26(34)35-2)25(30-23(32)9-15)24-20(27)11-17(12-21(24)28)29-16-3-4-18(33)10-16/h5-6,9,11-12,16,19,29H,3-4,7-8,10,13-14H2,1-2H3/t16?,19-/m0/s1 AYLUBVZDPHQQQF-CVMIBEPCSA-N 648686 US20240034729, Compound 79 P2X purinoceptor 3 Homo sapiens <100 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648686 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648686&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 154965144 494493547 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370678 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(NC3CCC(=O)CC3)cc2F)C1 InChI=1S/C27H30F2N4O4/c1-16-7-8-33-23(14-20-15-32(9-10-37-20)27(35)36-2)26(31-24(33)11-16)25-21(28)12-18(13-22(25)29)30-17-3-5-19(34)6-4-17/h7-8,11-13,17,20,30H,3-6,9-10,14-15H2,1-2H3/t20-/m0/s1 HRXZKQOSOUSOPW-FQEVSTJZSA-N 648687 US20240034729, Compound 80 P2X purinoceptor 3 Homo sapiens <100 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648687 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648687&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 154963277 494493548 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370679 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(NC3CCS(=O)(=O)C3)cc2F)C1 InChI=1S/C25H28F2N4O5S/c1-15-3-5-31-21(12-18-13-30(6-7-36-18)25(32)35-2)24(29-22(31)9-15)23-19(26)10-17(11-20(23)27)28-16-4-8-37(33,34)14-16/h3,5,9-11,16,18,28H,4,6-8,12-14H2,1-2H3/t16?,18-/m0/s1 SWGWJCRKYXMJKT-DAFXYXGESA-N 648688 US20240034729, Compound 81 P2X purinoceptor 3 Homo sapiens <10 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648688 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648688&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 166774898 494493549 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370680 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(NC(=O)C3CCC(CC3)C(O)=O)cc2F)C1 InChI=1S/C29H32F2N4O6/c1-16-7-8-35-23(14-20-15-34(9-10-41-20)29(39)40-2)26(33-24(35)11-16)25-21(30)12-19(13-22(25)31)32-27(36)17-3-5-18(6-4-17)28(37)38/h7-8,11-13,17-18,20H,3-6,9-10,14-15H2,1-2H3,(H,32,36)(H,37,38)/t17?,18?,20-/m0/s1 CKRQRYZZETUXLE-QLOJAFMTSA-N 648689 US20240034729, Compound 82 P2X purinoceptor 3 Homo sapiens <100 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648689 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648689&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 154965079 494493550 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370681 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(NC(=O)C3CCC(=O)CC3)cc2F)C1 InChI=1S/C28H30F2N4O5/c1-16-7-8-34-23(14-20-15-33(9-10-39-20)28(37)38-2)26(32-24(34)11-16)25-21(29)12-18(13-22(25)30)31-27(36)17-3-5-19(35)6-4-17/h7-8,11-13,17,20H,3-6,9-10,14-15H2,1-2H3,(H,31,36)/t20-/m0/s1 AEVODKLIGLYVCJ-FQEVSTJZSA-N 648690 US20240034729, Compound 83 P2X purinoceptor 3 Homo sapiens <1000 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648690 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648690&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 154965275 494493551 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370682 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(NC(=O)c3ccccc3)cc2F)C1 InChI=1S/C28H26F2N4O4/c1-17-8-9-34-23(15-20-16-33(10-11-38-20)28(36)37-2)26(32-24(34)12-17)25-21(29)13-19(14-22(25)30)31-27(35)18-6-4-3-5-7-18/h3-9,12-14,20H,10-11,15-16H2,1-2H3,(H,31,35)/t20-/m0/s1 SIZGZZWDYRLQOX-FQEVSTJZSA-N 648691 US20240034729, Compound 84 P2X purinoceptor 3 Homo sapiens <1000 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648691 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648691&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 154965154 494493552 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370683 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(NC(=O)c3ccc(cc3)C(O)=O)cc2F)C1 InChI=1S/C29H26F2N4O6/c1-16-7-8-35-23(14-20-15-34(9-10-41-20)29(39)40-2)26(33-24(35)11-16)25-21(30)12-19(13-22(25)31)32-27(36)17-3-5-18(6-4-17)28(37)38/h3-8,11-13,20H,9-10,14-15H2,1-2H3,(H,32,36)(H,37,38)/t20-/m0/s1 DCYJGAPCRMDGOP-FQEVSTJZSA-N 648692 US20240034729, Compound 85 P2X purinoceptor 3 Homo sapiens <1000 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648692 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648692&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 154965278 494493553 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370684 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(NC(=O)c3ccncc3)cc2F)C1 InChI=1S/C27H25F2N5O4/c1-16-5-8-34-22(14-19-15-33(9-10-38-19)27(36)37-2)25(32-23(34)11-16)24-20(28)12-18(13-21(24)29)31-26(35)17-3-6-30-7-4-17/h3-8,11-13,19H,9-10,14-15H2,1-2H3,(H,31,35)/t19-/m0/s1 QWBOFJHHTLXUCC-IBGZPJMESA-N 648693 US20240034729, Compound 86 P2X purinoceptor 3 Homo sapiens <100 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648693 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648693&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 154965130 494493554 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370685 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(NC(=O)C=C)cc2F)C1 InChI=1S/C24H24F2N4O4/c1-4-21(31)27-15-10-17(25)22(18(26)11-15)23-19(30-6-5-14(2)9-20(30)28-23)12-16-13-29(7-8-34-16)24(32)33-3/h4-6,9-11,16H,1,7-8,12-13H2,2-3H3,(H,27,31)/t16-/m0/s1 MGHBUHUUXHOMNV-INIZCTEOSA-N 648694 US20240034729, Compound 87 P2X purinoceptor 3 Homo sapiens <1000 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648694 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648694&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 154965279 494493555 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370686 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(NC(=O)C#CC(O)=O)cc2F)C1 InChI=1S/C25H22F2N4O6/c1-14-5-6-31-19(12-16-13-30(7-8-37-16)25(35)36-2)24(29-20(31)9-14)23-17(26)10-15(11-18(23)27)28-21(32)3-4-22(33)34/h5-6,9-11,16H,7-8,12-13H2,1-2H3,(H,28,32)(H,33,34)/t16-/m0/s1 VJLGESKVQHEKFO-INIZCTEOSA-N 648695 US20240034729, Compound 88 P2X purinoceptor 3 Homo sapiens <100 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648695 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648695&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 154965276 494493556 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370687 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(NC(=O)C3(CC3)C#N)cc2F)C1 InChI=1S/C26H25F2N5O4/c1-15-3-6-33-20(12-17-13-32(7-8-37-17)25(35)36-2)23(31-21(33)9-15)22-18(27)10-16(11-19(22)28)30-24(34)26(14-29)4-5-26/h3,6,9-11,17H,4-5,7-8,12-13H2,1-2H3,(H,30,34)/t17-/m0/s1 UNTANTFZHIOHSK-KRWDZBQOSA-N 648696 US20240034729, Compound 89 P2X purinoceptor 3 Homo sapiens <100 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648696 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648696&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 154965281 494493557 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370688 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(NC(=O)CC(C)(C)O)cc2F)C1 InChI=1S/C26H30F2N4O5/c1-15-5-6-32-20(12-17-14-31(7-8-37-17)25(34)36-4)24(30-21(32)9-15)23-18(27)10-16(11-19(23)28)29-22(33)13-26(2,3)35/h5-6,9-11,17,35H,7-8,12-14H2,1-4H3,(H,29,33)/t17-/m0/s1 SJLCNTYUXUJUQV-KRWDZBQOSA-N 648697 US20240034729, Compound 90 P2X purinoceptor 3 Homo sapiens <100 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648697 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648697&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 154965277 494493558 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370689 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(NC(=O)CC(C)(C)C(O)=O)cc2F)C1 InChI=1S/C27H30F2N4O6/c1-15-5-6-33-20(12-17-14-32(7-8-39-17)26(37)38-4)24(31-21(33)9-15)23-18(28)10-16(11-19(23)29)30-22(34)13-27(2,3)25(35)36/h5-6,9-11,17H,7-8,12-14H2,1-4H3,(H,30,34)(H,35,36)/t17-/m0/s1 WLUINIQCJAQCCO-KRWDZBQOSA-N 648698 US20240034729, Compound 91 P2X purinoceptor 3 Homo sapiens <10 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648698 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648698&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 154965097 494493559 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370690 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(NC(=O)CC(C)C(O)=O)cc2F)C1 InChI=1S/C26H28F2N4O6/c1-14-4-5-32-20(12-17-13-31(6-7-38-17)26(36)37-3)24(30-21(32)8-14)23-18(27)10-16(11-19(23)28)29-22(33)9-15(2)25(34)35/h4-5,8,10-11,15,17H,6-7,9,12-13H2,1-3H3,(H,29,33)(H,34,35)/t15?,17-/m0/s1 MUKYBUSEPPGTKW-LWKPJOBUSA-N 648699 US20240034729, Compound 92 P2X purinoceptor 3 Homo sapiens <100 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648699 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648699&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 154965093 494493560 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370691 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(NC(=O)CCC(C)(C)O)cc2F)C1 InChI=1S/C27H32F2N4O5/c1-16-6-8-33-21(14-18-15-32(9-10-38-18)26(35)37-4)25(31-22(33)11-16)24-19(28)12-17(13-20(24)29)30-23(34)5-7-27(2,3)36/h6,8,11-13,18,36H,5,7,9-10,14-15H2,1-4H3,(H,30,34)/t18-/m0/s1 UJUBWMVUUYUSQQ-SFHVURJKSA-N 648700 US20240034729, Compound 93 P2X purinoceptor 3 Homo sapiens <100 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648700 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648700&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 154965461 494493561 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370692 CNC(=O)c1cc(F)c(-c2nc3cc(C)cnc3n2C[C@H]2CN(CCO2)C(=O)OC)c(F)c1 InChI=1S/C22H23F2N5O4/c1-12-6-17-19(26-9-12)29(11-14-10-28(4-5-33-14)22(31)32-3)20(27-17)18-15(23)7-13(8-16(18)24)21(30)25-2/h6-9,14H,4-5,10-11H2,1-3H3,(H,25,30)/t14-/m1/s1 OSSJRMGLNAOEQO-CQSZACIVSA-N 648701 US20240034729, Compound 94 P2X purinoceptor 3 Homo sapiens <1000 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648701 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648701&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 153626336 494493562 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370693 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(NC(=O)CC3(CC3)C(O)=O)cc2F)C1 InChI=1S/C27H28F2N4O6/c1-15-3-6-33-20(12-17-14-32(7-8-39-17)26(37)38-2)24(31-21(33)9-15)23-18(28)10-16(11-19(23)29)30-22(34)13-27(4-5-27)25(35)36/h3,6,9-11,17H,4-5,7-8,12-14H2,1-2H3,(H,30,34)(H,35,36)/t17-/m0/s1 ZVTRDKXXIBGNKX-KRWDZBQOSA-N 648702 US20240034729, Compound 95 P2X purinoceptor 3 Homo sapiens <100 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648702 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648702&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 154965028 494493563 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370694 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(NC(=O)CC3(CC3)C#N)cc2F)C1 InChI=1S/C27H27F2N5O4/c1-16-3-6-34-21(12-18-14-33(7-8-38-18)26(36)37-2)25(32-22(34)9-16)24-19(28)10-17(11-20(24)29)31-23(35)13-27(15-30)4-5-27/h3,6,9-11,18H,4-5,7-8,12-14H2,1-2H3,(H,31,35)/t18-/m0/s1 IGRMSRDFCVJUGD-SFHVURJKSA-N 648703 US20240034729, Compound 96 P2X purinoceptor 3 Homo sapiens <100 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648703 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648703&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 171362256 494493564 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370695 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(NC(=O)C3(CC3)C(=O)OC)cc2F)C1 InChI=1S/C27H28F2N4O6/c1-15-4-7-33-20(13-17-14-32(8-9-39-17)26(36)38-3)23(31-21(33)10-15)22-18(28)11-16(12-19(22)29)30-24(34)27(5-6-27)25(35)37-2/h4,7,10-12,17H,5-6,8-9,13-14H2,1-3H3,(H,30,34)/t17-/m0/s1 KXHLTBFXFNDLCI-KRWDZBQOSA-N 648704 US20240034729, Compound 97 P2X purinoceptor 3 Homo sapiens <1000 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648704 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648704&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 154965048 494493565 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370696 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(cc2F)-n2cc[nH]c2=O)C1 648705 US20240034729, Compound 98 P2X purinoceptor 3 Homo sapiens <100 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648705 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648705&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 154965094 494493566 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370697 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(NC(=O)C3(CC3)C(=O)OC)cc2F)C1 InChI=1S/C27H28F2N4O6/c1-15-4-7-33-20(13-17-14-32(8-9-39-17)26(36)38-3)23(31-21(33)10-15)22-18(28)11-16(12-19(22)29)30-24(34)27(5-6-27)25(35)37-2/h4,7,10-12,17H,5-6,8-9,13-14H2,1-3H3,(H,30,34)/t17-/m0/s1 KXHLTBFXFNDLCI-KRWDZBQOSA-N 648704 US20240034729, Compound 97 P2X purinoceptor 3 Homo sapiens <1000 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648704 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648704&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 154965048 494493565 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370698 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(cc2F)-n2cc[nH]c2=O)C1 648705 US20240034729, Compound 98 P2X purinoceptor 3 Homo sapiens <100 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648705 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648705&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 154965094 494493566 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370699 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(cc2F)-n2ccoc2=O)C1 InChI=1S/C24H22F2N4O5/c1-14-3-4-30-19(12-16-13-28(5-7-34-16)23(31)33-2)22(27-20(30)9-14)21-17(25)10-15(11-18(21)26)29-6-8-35-24(29)32/h3-4,6,8-11,16H,5,7,12-13H2,1-2H3/t16-/m0/s1 IYSWFSPPXVDRBV-INIZCTEOSA-N 648706 US20240034729, Compound 99 P2X purinoceptor 3 Homo sapiens <100 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648706 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648706&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 154965098 494493567 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370700 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(cc2F)N2C=CCC2=O)C1 InChI=1S/C25H24F2N4O4/c1-15-5-7-31-20(13-17-14-29(8-9-35-17)25(33)34-2)24(28-21(31)10-15)23-18(26)11-16(12-19(23)27)30-6-3-4-22(30)32/h3,5-7,10-12,17H,4,8-9,13-14H2,1-2H3/t17-/m0/s1 VCINWMOOLSNDOA-KRWDZBQOSA-N 648707 US20240034729, Compound 100 P2X purinoceptor 3 Homo sapiens <100 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648707 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648707&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 154965095 494493568 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370701 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(cc2F)N2CCCC2=O)C1 InChI=1S/C25H26F2N4O4/c1-15-5-7-31-20(13-17-14-29(8-9-35-17)25(33)34-2)24(28-21(31)10-15)23-18(26)11-16(12-19(23)27)30-6-3-4-22(30)32/h5,7,10-12,17H,3-4,6,8-9,13-14H2,1-2H3/t17-/m0/s1 RPXIVVLAYZXEBH-KRWDZBQOSA-N 648708 US20240034729, Compound 101 P2X purinoceptor 3 Homo sapiens <100 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648708 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648708&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 154965096 494493569 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370702 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(cc2F)-c2ccn(n2)C(F)F)C1 InChI=1S/C25H23F4N5O3/c1-14-3-5-33-20(12-16-13-32(7-8-37-16)25(35)36-2)23(30-21(33)9-14)22-17(26)10-15(11-18(22)27)19-4-6-34(31-19)24(28)29/h3-6,9-11,16,24H,7-8,12-13H2,1-2H3/t16-/m0/s1 JXFJHMSYFZHYBB-INIZCTEOSA-N 648709 US20240034729, Compound 102 P2X purinoceptor 3 Homo sapiens <10 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648709 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648709&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 154965099 494493570 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370703 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(F)ccn23)-c2c(F)cc(cc2F)-c2cc[nH]n2)C1 648710 US20240034729, Compound 103 P2X purinoceptor 3 Homo sapiens <1000 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648710 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648710&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 167370672 494493571 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370704 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(cc2F)-c2nn[nH]n2)C1 648711 US20240034729, Compound 104 P2X purinoceptor 3 Homo sapiens <1000 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648711 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648711&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 154965007 494493572 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370705 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(cc2F)-c2nc(c[nH]2)S(N)(=O)=O)C1 648712 US20240034729, Compound 105 P2X purinoceptor 3 Homo sapiens <10 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648712 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648712&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 154965006 494493573 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370706 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(F)ccn23)-c2c(F)cc(cc2F)-c2nc(c[nH]2)C#N)C1 648713 US20240034729, Compound 106 P2X purinoceptor 3 Homo sapiens <100 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648713 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648713&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 167370654 494493574 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370707 CCOC(=O)c1cn(cn1)-c1cc(F)c(-c2nc3cc(C)ccn3c2C[C@H]2CN(CCO2)C(=O)OC)c(F)c1 InChI=1S/C27H27F2N5O5/c1-4-38-26(35)21-14-33(15-30-21)17-10-19(28)24(20(29)11-17)25-22(34-6-5-16(2)9-23(34)31-25)12-18-13-32(7-8-39-18)27(36)37-3/h5-6,9-11,14-15,18H,4,7-8,12-13H2,1-3H3/t18-/m0/s1 MXIMIFGDDKEXFY-SFHVURJKSA-N 648714 US20240034729, Compound 107 P2X purinoceptor 3 Homo sapiens <100 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648714 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648714&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 154965110 494493575 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370708 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(cc2F)-n2cnc(c2)C(=O)OC)C1 InChI=1S/C26H25F2N5O5/c1-15-4-5-33-21(11-17-12-31(6-7-38-17)26(35)37-3)24(30-22(33)8-15)23-18(27)9-16(10-19(23)28)32-13-20(29-14-32)25(34)36-2/h4-5,8-10,13-14,17H,6-7,11-12H2,1-3H3/t17-/m0/s1 QKZRNYRQDAWJAL-KRWDZBQOSA-N 648715 US20240034729, Compound 108 P2X purinoceptor 3 Homo sapiens >1000 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648715 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648715&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 154965009 494493576 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370709 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(cc2F)-n2cnc(c2)C(F)(F)F)C1 InChI=1S/C25H22F5N5O3/c1-14-3-4-35-19(10-16-11-33(5-6-38-16)24(36)37-2)23(32-21(35)7-14)22-17(26)8-15(9-18(22)27)34-12-20(31-13-34)25(28,29)30/h3-4,7-9,12-13,16H,5-6,10-11H2,1-2H3/t16-/m0/s1 UKOGLYYJRRCSRK-INIZCTEOSA-N 648716 US20240034729, Compound 109 P2X purinoceptor 3 Homo sapiens <1000 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648716 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648716&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 153626224 494493577 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370710 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(cc2F)-n2cnc(c2)C(N)=O)C1 InChI=1S/C25H24F2N6O4/c1-14-3-4-33-20(10-16-11-31(5-6-37-16)25(35)36-2)23(30-21(33)7-14)22-17(26)8-15(9-18(22)27)32-12-19(24(28)34)29-13-32/h3-4,7-9,12-13,16H,5-6,10-11H2,1-2H3,(H2,28,34)/t16-/m0/s1 DUBQBBQNIINGFR-INIZCTEOSA-N 648717 US20240034729, Compound 110 P2X purinoceptor 3 Homo sapiens <100 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648717 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648717&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 153626442 494493578 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370711 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(cc2F)-n2cnc(N)c2)C1 InChI=1S/C24H24F2N6O3/c1-14-3-4-32-19(10-16-11-30(5-6-35-16)24(33)34-2)23(29-21(32)7-14)22-17(25)8-15(9-18(22)26)31-12-20(27)28-13-31/h3-4,7-9,12-13,16H,5-6,10-11,27H2,1-2H3/t16-/m0/s1 KJGDQKROGPCJFL-INIZCTEOSA-N 648718 US20240034729, Compound 111 P2X purinoceptor 3 Homo sapiens <100 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648718 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648718&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 154965008 494493579 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370712 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(cc2F)-n2cnc(OC)c2)C1 InChI=1S/C25H25F2N5O4/c1-15-4-5-32-20(11-17-12-30(6-7-36-17)25(33)35-3)24(29-21(32)8-15)23-18(26)9-16(10-19(23)27)31-13-22(34-2)28-14-31/h4-5,8-10,13-14,17H,6-7,11-12H2,1-3H3/t17-/m0/s1 QYNBZVJSFFQDKM-KRWDZBQOSA-N 648719 US20240034729, Compound 112 P2X purinoceptor 3 Homo sapiens >1000 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648719 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648719&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 154965015 494493580 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370713 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(cc2F)-n2cnc(c2)C2(CC2)C(O)=O)C1 InChI=1S/C28H27F2N5O5/c1-16-3-6-35-21(12-18-13-33(7-8-40-18)27(38)39-2)25(32-23(35)9-16)24-19(29)10-17(11-20(24)30)34-14-22(31-15-34)28(4-5-28)26(36)37/h3,6,9-11,14-15,18H,4-5,7-8,12-13H2,1-2H3,(H,36,37)/t18-/m0/s1 BAZTYLNIKJKEKE-SFHVURJKSA-N 648720 US20240034729, Compound 113 P2X purinoceptor 3 Homo sapiens >1000 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648720 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648720&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 163444064 494493581 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370714 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(cc2F)-c2nc(co2)C(O)=O)C1 InChI=1S/C25H22F2N4O6/c1-13-3-4-31-19(10-15-11-30(5-6-36-15)25(34)35-2)22(29-20(31)7-13)21-16(26)8-14(9-17(21)27)23-28-18(12-37-23)24(32)33/h3-4,7-9,12,15H,5-6,10-11H2,1-2H3,(H,32,33)/t15-/m0/s1 SRMMPMWFSANYGN-HNNXBMFYSA-N 648721 US20240034729, Compound 114 P2X purinoceptor 3 Homo sapiens <100 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648721 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648721&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 153626357 494493582 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370715 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(cc2F)-c2nc(c[nH]2)C(C)(C)O)C1 648722 US20240034729, Compound 115 P2X purinoceptor 3 Homo sapiens >1000 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648722 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648722&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 171362257 494493583 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370716 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(cc2F)-c2nc(c[nH]2)C2(O)CC2)C1 648723 US20240034729, Compound 116 P2X purinoceptor 3 Homo sapiens <100 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648723 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648723&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 171362258 494493584 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370717 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(cc2F)-n2cnc(c2)C(C)(C)O)C1 InChI=1S/C27H29F2N5O4/c1-16-5-6-34-21(12-18-13-32(7-8-38-18)26(35)37-4)25(31-23(34)9-16)24-19(28)10-17(11-20(24)29)33-14-22(30-15-33)27(2,3)36/h5-6,9-11,14-15,18,36H,7-8,12-13H2,1-4H3/t18-/m0/s1 CXGFTFCYHBKFMS-SFHVURJKSA-N 648724 US20240034729, Compound 117 P2X purinoceptor 3 Homo sapiens <100 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648724 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648724&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 153626347 494493585 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370718 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(cc2F)-c2nc(co2)C2(O)CC2)C1 InChI=1S/C27H26F2N4O5/c1-15-3-6-33-20(12-17-13-32(7-8-37-17)26(34)36-2)24(31-22(33)9-15)23-18(28)10-16(11-19(23)29)25-30-21(14-38-25)27(35)4-5-27/h3,6,9-11,14,17,35H,4-5,7-8,12-13H2,1-2H3/t17-/m0/s1 LUHIGPCIMXNNPY-KRWDZBQOSA-N 648725 US20240034729, Compound 118 P2X purinoceptor 3 Homo sapiens >1000 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648725 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648725&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 154965104 494493586 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370719 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(cc2F)-c2nc(co2)C(C)(C)O)C1 InChI=1S/C27H28F2N4O5/c1-15-5-6-33-20(12-17-13-32(7-8-37-17)26(34)36-4)24(31-22(33)9-15)23-18(28)10-16(11-19(23)29)25-30-21(14-38-25)27(2,3)35/h5-6,9-11,14,17,35H,7-8,12-13H2,1-4H3/t17-/m0/s1 OFIPZKBQMMMFOP-KRWDZBQOSA-N 648726 US20240034729, Compound 119 P2X purinoceptor 3 Homo sapiens <100 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648726 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648726&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 154965105 494493587 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370720 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(cc2F)-c2ncc(o2)C#N)C1 InChI=1S/C25H21F2N5O4/c1-14-3-4-32-20(10-16-13-31(5-6-35-16)25(33)34-2)23(30-21(32)7-14)22-18(26)8-15(9-19(22)27)24-29-12-17(11-28)36-24/h3-4,7-9,12,16H,5-6,10,13H2,1-2H3/t16-/m0/s1 RHHWLVKOBFUPDX-INIZCTEOSA-N 648727 US20240034729, Compound 120 P2X purinoceptor 3 Homo sapiens <10 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648727 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648727&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 154965107 494493588 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370721 CCC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(cc2F)-c2nc(co2)C#N)C1 InChI=1S/C26H23F2N5O3/c1-3-23(34)32-6-7-35-18(13-32)11-21-25(31-22-8-15(2)4-5-33(21)22)24-19(27)9-16(10-20(24)28)26-30-17(12-29)14-36-26/h4-5,8-10,14,18H,3,6-7,11,13H2,1-2H3/t18-/m0/s1 FJXWJLZDMJRDNA-SFHVURJKSA-N 648728 US20240034729, Compound 121 P2X purinoceptor 3 Homo sapiens >1000 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648728 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648728&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 167370609 494493589 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370722 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(F)ccn23)-c2c(F)cc(cc2F)-c2ncco2)C1 InChI=1S/C23H19F3N4O4/c1-32-23(31)29-5-7-33-15(12-29)11-18-21(28-19-10-14(24)2-4-30(18)19)20-16(25)8-13(9-17(20)26)22-27-3-6-34-22/h2-4,6,8-10,15H,5,7,11-12H2,1H3/t15-/m0/s1 VOOBBKPHVWRFOU-HNNXBMFYSA-N 648729 US20240034729, Compound 122 P2X purinoceptor 3 Homo sapiens >1000 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648729 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648729&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 167370643 494493590 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370723 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(CF)ccn23)-c2c(F)cc(cc2F)-c2ncco2)C1 InChI=1S/C24H21F3N4O4/c1-33-24(32)30-5-7-34-16(13-30)11-19-22(29-20-8-14(12-25)2-4-31(19)20)21-17(26)9-15(10-18(21)27)23-28-3-6-35-23/h2-4,6,8-10,16H,5,7,11-13H2,1H3/t16-/m0/s1 XPYOXIVNHJLPEC-INIZCTEOSA-N 648730 US20240034729, Compound 123 P2X purinoceptor 3 Homo sapiens <1000 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648730 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648730&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 171362259 494493591 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370724 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(cc2F)-n2ccc(n2)C#N)C1 InChI=1S/C25H22F2N6O3/c1-15-3-5-32-21(12-18-14-31(7-8-36-18)25(34)35-2)24(29-22(32)9-15)23-19(26)10-17(11-20(23)27)33-6-4-16(13-28)30-33/h3-6,9-11,18H,7-8,12,14H2,1-2H3/t18-/m0/s1 AUTBULIBMAVZGF-SFHVURJKSA-N 648731 US20240034729, Compound 124 P2X purinoceptor 3 Homo sapiens <10 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648731 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648731&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 167370613 494493592 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370725 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(cc2F)-n2nccc2C#N)C1 InChI=1S/C25H22F2N6O3/c1-15-4-6-32-21(12-18-14-31(7-8-36-18)25(34)35-2)24(30-22(32)9-15)23-19(26)10-17(11-20(23)27)33-16(13-28)3-5-29-33/h3-6,9-11,18H,7-8,12,14H2,1-2H3/t18-/m0/s1 UVHUFCCRQSVXIS-SFHVURJKSA-N 648732 US20240034729, Compound 124-2 P2X purinoceptor 3 Homo sapiens <10 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648732 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648732&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 171362260 494493593 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370726 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(cc2F)-n2ccc(n2)C(O)=O)C1 InChI=1S/C25H23F2N5O5/c1-14-3-5-31-20(12-16-13-30(7-8-37-16)25(35)36-2)23(28-21(31)9-14)22-17(26)10-15(11-18(22)27)32-6-4-19(29-32)24(33)34/h3-6,9-11,16H,7-8,12-13H2,1-2H3,(H,33,34)/t16-/m0/s1 MECSAZUXEWBMCQ-INIZCTEOSA-N 648733 US20240034729, Compound 125 P2X purinoceptor 3 Homo sapiens <10 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648733 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648733&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 153626302 494493594 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370727 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(cc2F)-n2ccc(n2)C(C)(C)O)C1 InChI=1S/C27H29F2N5O4/c1-16-5-7-33-21(14-18-15-32(9-10-38-18)26(35)37-4)25(30-23(33)11-16)24-19(28)12-17(13-20(24)29)34-8-6-22(31-34)27(2,3)36/h5-8,11-13,18,36H,9-10,14-15H2,1-4H3/t18-/m0/s1 YAEJFPNTIZVYPX-SFHVURJKSA-N 648734 US20240034729, Compound 126 P2X purinoceptor 3 Homo sapiens <100 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648734 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648734&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 153626409 494493595 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370728 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(cc2F)-n2cc(N)cn2)C1 InChI=1S/C24H24F2N6O3/c1-14-3-4-31-20(10-17-13-30(5-6-35-17)24(33)34-2)23(29-21(31)7-14)22-18(25)8-16(9-19(22)26)32-12-15(27)11-28-32/h3-4,7-9,11-12,17H,5-6,10,13,27H2,1-2H3/t17-/m0/s1 XCYOXZQHMOYNGN-KRWDZBQOSA-N 648735 US20240034729, Compound 127 P2X purinoceptor 3 Homo sapiens <10 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648735 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648735&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 153626438 494493596 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370729 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(cc2F)-n2cc(O)cn2)C1 InChI=1S/C24H23F2N5O4/c1-14-3-4-30-20(10-17-13-29(5-6-35-17)24(33)34-2)23(28-21(30)7-14)22-18(25)8-15(9-19(22)26)31-12-16(32)11-27-31/h3-4,7-9,11-12,17,32H,5-6,10,13H2,1-2H3/t17-/m0/s1 DZMNNFUCZBLEQC-KRWDZBQOSA-N 648736 US20240034729, Compound 128 P2X purinoceptor 3 Homo sapiens >1000 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648736 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648736&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 153626490 494493597 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370730 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(cc2F)-n2cc(OC)cn2)C1 InChI=1S/C25H25F2N5O4/c1-15-4-5-31-21(11-17-13-30(6-7-36-17)25(33)35-3)24(29-22(31)8-15)23-19(26)9-16(10-20(23)27)32-14-18(34-2)12-28-32/h4-5,8-10,12,14,17H,6-7,11,13H2,1-3H3/t17-/m0/s1 YXERDMIXKKUTBA-KRWDZBQOSA-N 648737 US20240034729, Compound 129 P2X purinoceptor 3 Homo sapiens <100 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648737 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648737&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 153626335 494493598 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370731 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(cc2F)-n2ccc(n2)C2(CC2)C(O)=O)C1 InChI=1S/C28H27F2N5O5/c1-16-3-7-34-21(14-18-15-33(9-10-40-18)27(38)39-2)25(31-23(34)11-16)24-19(29)12-17(13-20(24)30)35-8-4-22(32-35)28(5-6-28)26(36)37/h3-4,7-8,11-13,18H,5-6,9-10,14-15H2,1-2H3,(H,36,37)/t18-/m0/s1 IGPYHWAZSZBEEK-SFHVURJKSA-N 648738 US20240034729, Compound 130 P2X purinoceptor 3 Homo sapiens >1000 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648738 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648738&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 154965109 494493599 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370732 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(cc2F)-n2ccc(n2)C2(O)CC2)C1 InChI=1S/C27H27F2N5O4/c1-16-3-7-33-21(14-18-15-32(9-10-38-18)26(35)37-2)25(30-23(33)11-16)24-19(28)12-17(13-20(24)29)34-8-4-22(31-34)27(36)5-6-27/h3-4,7-8,11-13,18,36H,5-6,9-10,14-15H2,1-2H3/t18-/m0/s1 KPIJFSYPQGZGST-SFHVURJKSA-N 648739 US20240034729, Compound 131 P2X purinoceptor 3 Homo sapiens <100 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648739 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648739&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 167370630 494493600 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370733 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(F)ccn23)-c2c(F)cc(cc2F)-n2ccnc2)C1 InChI=1S/C23H20F3N5O3/c1-33-23(32)29-6-7-34-16(12-29)11-19-22(28-20-8-14(24)2-4-31(19)20)21-17(25)9-15(10-18(21)26)30-5-3-27-13-30/h2-5,8-10,13,16H,6-7,11-12H2,1H3/t16-/m0/s1 MZLZAESZASPLRQ-INIZCTEOSA-N 648740 US20240034729, Compound 132 P2X purinoceptor 3 Homo sapiens <10 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648740 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648740&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 167370661 494493601 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370734 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(cc2F)-c2nc(c[nH]2)C2(CC2)C(N)=O)C1 648741 US20240034729, Compound 133 P2X purinoceptor 3 Homo sapiens <100 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648741 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648741&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 153626457 494493602 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370735 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(cc2F)-n2ccc(c2)S(N)(=O)=O)C1 InChI=1S/C25H25F2N5O5S/c1-15-3-6-32-21(12-17-13-31(7-8-37-17)25(33)36-2)24(29-22(32)9-15)23-19(26)10-16(11-20(23)27)30-5-4-18(14-30)38(28,34)35/h3-6,9-11,14,17H,7-8,12-13H2,1-2H3,(H2,28,34,35)/t17-/m0/s1 UUDNESCTZRXBLD-KRWDZBQOSA-N 648742 US20240034729, Compound 134 P2X purinoceptor 3 Homo sapiens <100 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648742 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648742&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 153626355 494493603 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370736 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(cc2F)-n2ccc(c2)C(C)(C)O)C1 InChI=1S/C28H30F2N4O4/c1-17-5-8-34-23(14-20-16-33(9-10-38-20)27(35)37-4)26(31-24(34)11-17)25-21(29)12-19(13-22(25)30)32-7-6-18(15-32)28(2,3)36/h5-8,11-13,15,20,36H,9-10,14,16H2,1-4H3/t20-/m0/s1 JGPMUNMMIXHBES-FQEVSTJZSA-N 648743 US20240034729, Compound 135 P2X purinoceptor 3 Homo sapiens <10 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648743 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648743&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 154965201 494493604 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370737 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(cc2F)-n2ccc(c2)C2(CC2)C(O)=O)C1 InChI=1S/C29H28F2N4O5/c1-17-3-8-35-23(14-20-16-34(9-10-40-20)28(38)39-2)26(32-24(35)11-17)25-21(30)12-19(13-22(25)31)33-7-4-18(15-33)29(5-6-29)27(36)37/h3-4,7-8,11-13,15,20H,5-6,9-10,14,16H2,1-2H3,(H,36,37)/t20-/m0/s1 PSWCNEDYODMWHE-FQEVSTJZSA-N 648744 US20240034729, Compound 136 P2X purinoceptor 3 Homo sapiens <1000 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648744 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648744&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 154965273 494493605 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370738 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(cc2F)-n2ccc(c2)C#N)C1 InChI=1S/C26H23F2N5O3/c1-16-3-6-33-22(12-19-15-32(7-8-36-19)26(34)35-2)25(30-23(33)9-16)24-20(27)10-18(11-21(24)28)31-5-4-17(13-29)14-31/h3-6,9-11,14,19H,7-8,12,15H2,1-2H3/t19-/m0/s1 IZKIHYMMCRIIPC-IBGZPJMESA-N 648745 US20240034729, Compound 137 P2X purinoceptor 3 Homo sapiens <100 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648745 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648745&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 154965274 494493606 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370739 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(cc2F)-c2ccc([nH]2)C#N)C1 648746 US20240034729, Compound 138 P2X purinoceptor 3 Homo sapiens <10 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648746 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648746&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 153626255 494493607 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370740 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(cc2F)-c2ccc(s2)C#N)C1 InChI=1S/C26H22F2N4O3S/c1-15-5-6-32-21(12-17-14-31(7-8-35-17)26(33)34-2)25(30-23(32)9-15)24-19(27)10-16(11-20(24)28)22-4-3-18(13-29)36-22/h3-6,9-11,17H,7-8,12,14H2,1-2H3/t17-/m0/s1 DYILCHPLITZKTH-KRWDZBQOSA-N 648747 US20240034729, Compound 139 P2X purinoceptor 3 Homo sapiens <10 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648747 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648747&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 153626292 494493608 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370741 CCC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(cc2F)-c2ccc(s2)C#N)C1 InChI=1S/C27H24F2N4O2S/c1-3-25(34)32-8-9-35-18(15-32)13-22-27(31-24-10-16(2)6-7-33(22)24)26-20(28)11-17(12-21(26)29)23-5-4-19(14-30)36-23/h4-7,10-12,18H,3,8-9,13,15H2,1-2H3/t18-/m0/s1 MTHVMCRVAPBBHT-SFHVURJKSA-N 648748 US20240034729, Compound 140 P2X purinoceptor 3 Homo sapiens <1000 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648748 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648748&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 153626253 494493609 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370742 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(cc2F)-n2ccnn2)C1 InChI=1S/C23H22F2N6O3/c1-14-3-5-30-19(12-16-13-29(7-8-34-16)23(32)33-2)22(27-20(30)9-14)21-17(24)10-15(11-18(21)25)31-6-4-26-28-31/h3-6,9-11,16H,7-8,12-13H2,1-2H3/t16-/m0/s1 JBKGIKJEOYOVJT-INIZCTEOSA-N 648749 US20240034729, Compound 141 P2X purinoceptor 3 Homo sapiens <100 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648749 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648749&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 153626221 494493610 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370743 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(cc2F)-n2cncn2)C1 InChI=1S/C23H22F2N6O3/c1-14-3-4-30-19(10-16-11-29(5-6-34-16)23(32)33-2)22(28-20(30)7-14)21-17(24)8-15(9-18(21)25)31-13-26-12-27-31/h3-4,7-9,12-13,16H,5-6,10-11H2,1-2H3/t16-/m0/s1 XNBQCANVPGBZJK-INIZCTEOSA-N 648750 US20240034729, Compound 142 P2X purinoceptor 3 Homo sapiens <10 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648750 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648750&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 153626344 494493611 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370744 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(cc2F)-n2cnnc2)C1 InChI=1S/C23H22F2N6O3/c1-14-3-4-31-19(10-16-11-29(5-6-34-16)23(32)33-2)22(28-20(31)7-14)21-17(24)8-15(9-18(21)25)30-12-26-27-13-30/h3-4,7-9,12-13,16H,5-6,10-11H2,1-2H3/t16-/m0/s1 SUAVPRVLAFJZDG-INIZCTEOSA-N 648751 US20240034729, Compound 143 P2X purinoceptor 3 Homo sapiens <10 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648751 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648751&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 153626317 494493612 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370745 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(cc2F)-c2nc(c[nH]2)C2(CC2)C#N)C1 648752 US20240034729, Compound 144 P2X purinoceptor 3 Homo sapiens <100 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648752 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648752&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 154965254 494493613 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370746 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(cc2F)-c2ccc(cn2)C(O)=O)C1 InChI=1S/C27H24F2N4O5/c1-15-5-6-33-22(12-18-14-32(7-8-38-18)27(36)37-2)25(31-23(33)9-15)24-19(28)10-17(11-20(24)29)21-4-3-16(13-30-21)26(34)35/h3-6,9-11,13,18H,7-8,12,14H2,1-2H3,(H,34,35)/t18-/m0/s1 AUQQRSKFELDPDA-SFHVURJKSA-N 648753 US20240034729, Compound 145 P2X purinoceptor 3 Homo sapiens <1000 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648753 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648753&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 154965271 494493614 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370747 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(cc2F)-c2ccc(cn2)C(N)=O)C1 InChI=1S/C27H25F2N5O4/c1-15-5-6-34-22(12-18-14-33(7-8-38-18)27(36)37-2)25(32-23(34)9-15)24-19(28)10-17(11-20(24)29)21-4-3-16(13-31-21)26(30)35/h3-6,9-11,13,18H,7-8,12,14H2,1-2H3,(H2,30,35)/t18-/m0/s1 YYWHCKZYOIPLQV-SFHVURJKSA-N 648754 US20240034729, Compound 146 P2X purinoceptor 3 Homo sapiens <1000 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648754 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648754&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 166775107 494493615 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370748 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(cc2F)-c2ccc(O)cn2)C1 InChI=1S/C26H24F2N4O4/c1-15-5-6-32-22(12-18-14-31(7-8-36-18)26(34)35-2)25(30-23(32)9-15)24-19(27)10-16(11-20(24)28)21-4-3-17(33)13-29-21/h3-6,9-11,13,18,33H,7-8,12,14H2,1-2H3/t18-/m0/s1 CFAZLMNWVPDPMK-SFHVURJKSA-N 648755 US20240034729, Compound 147 P2X purinoceptor 3 Homo sapiens <100 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648755 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648755&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 154965266 494493616 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370749 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(F)ccn23)-c2c(F)cc(NC(C)=O)cc2F)C1 InChI=1S/C22H21F3N4O4/c1-12(30)26-14-8-16(24)20(17(25)9-14)21-18(29-4-3-13(23)7-19(29)27-21)10-15-11-28(5-6-33-15)22(31)32-2/h3-4,7-9,15H,5-6,10-11H2,1-2H3,(H,26,30)/t15-/m0/s1 NIWZUSGHRKTKOP-HNNXBMFYSA-N 648756 US20240034729, Compound 148 P2X purinoceptor 3 Homo sapiens <10 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648756 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648756&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 166774831 494493617 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370750 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(Cl)ccn23)-c2c(F)cc(NC(C)=O)cc2F)C1 InChI=1S/C22H21ClF2N4O4/c1-12(30)26-14-8-16(24)20(17(25)9-14)21-18(29-4-3-13(23)7-19(29)27-21)10-15-11-28(5-6-33-15)22(31)32-2/h3-4,7-9,15H,5-6,10-11H2,1-2H3,(H,26,30)/t15-/m0/s1 XHFWVYFTKCABIN-HNNXBMFYSA-N 648757 US20240034729, Compound 149 P2X purinoceptor 3 Homo sapiens <10 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648757 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648757&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 154965433 494493618 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370751 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(CF)ccn23)-c2c(F)cc(NC(C)=O)cc2F)C1 InChI=1S/C23H23F3N4O4/c1-13(31)27-15-8-17(25)21(18(26)9-15)22-19(30-4-3-14(11-24)7-20(30)28-22)10-16-12-29(5-6-34-16)23(32)33-2/h3-4,7-9,16H,5-6,10-12H2,1-2H3,(H,27,31)/t16-/m0/s1 RXDILMNGTKCZNA-INIZCTEOSA-N 648758 US20240034729, Compound 150 P2X purinoceptor 3 Homo sapiens <10 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648758 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648758&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 157022150 494493619 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370752 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(ccn23)C(F)F)-c2c(F)cc(NC(C)=O)cc2F)C1 InChI=1S/C23H22F4N4O4/c1-12(32)28-14-8-16(24)20(17(25)9-14)21-18(10-15-11-30(5-6-35-15)23(33)34-2)31-4-3-13(22(26)27)7-19(31)29-21/h3-4,7-9,15,22H,5-6,10-11H2,1-2H3,(H,28,32)/t15-/m0/s1 SRMLAUKLMPAJSX-HNNXBMFYSA-N 648759 US20240034729, Compound 151 P2X purinoceptor 3 Homo sapiens <10 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648759 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648759&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 171362261 494493620 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370753 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(NS(C)(=O)=O)cc2F)C1 InChI=1S/C22H24F2N4O5S/c1-13-4-5-28-18(11-15-12-27(6-7-33-15)22(29)32-2)21(25-19(28)8-13)20-16(23)9-14(10-17(20)24)26-34(3,30)31/h4-5,8-10,15,26H,6-7,11-12H2,1-3H3/t15-/m0/s1 OVXYLKKNMLXPKV-HNNXBMFYSA-N 648760 US20240034729, Compound 152 P2X purinoceptor 3 Homo sapiens <10 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648760 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648760&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 162354672 494493621 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370754 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(ccn23)C(F)(F)F)-c2c(F)cc(NC(C)=O)cc2F)C1 InChI=1S/C23H21F5N4O4/c1-12(33)29-14-8-16(24)20(17(25)9-14)21-18(10-15-11-31(5-6-36-15)22(34)35-2)32-4-3-13(23(26,27)28)7-19(32)30-21/h3-4,7-9,15H,5-6,10-11H2,1-2H3,(H,29,33)/t15-/m0/s1 KNCFIKPDOVAFJO-HNNXBMFYSA-N 648761 US20240034729, Compound 153 P2X purinoceptor 3 Homo sapiens <1000 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648761 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648761&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 157022151 494493622 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370755 CCC(=O)N1CCO[C@@H](Cc2c(nc3cc(Cl)ccn23)-c2c(F)cc(NC(C)=O)cc2F)C1 InChI=1S/C23H23ClF2N4O3/c1-3-21(32)29-6-7-33-16(12-29)11-19-23(28-20-8-14(24)4-5-30(19)20)22-17(25)9-15(10-18(22)26)27-13(2)31/h4-5,8-10,16H,3,6-7,11-12H2,1-2H3,(H,27,31)/t16-/m0/s1 ATVQONMUHGBRAN-INIZCTEOSA-N 648762 US20240034729, Compound 154 P2X purinoceptor 3 Homo sapiens <10 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648762 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648762&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 163435144 494493623 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370756 CCC(=O)N1CCO[C@@H](Cc2c(nc3cc(CF)ccn23)-c2c(F)cc(NC(C)=O)cc2F)C1 InChI=1S/C24H25F3N4O3/c1-3-22(33)30-6-7-34-17(13-30)11-20-24(29-21-8-15(12-25)4-5-31(20)21)23-18(26)9-16(10-19(23)27)28-14(2)32/h4-5,8-10,17H,3,6-7,11-13H2,1-2H3,(H,28,32)/t17-/m0/s1 TWTZPXJRQNXHFB-KRWDZBQOSA-N 648763 US20240034729, Compound 155 P2X purinoceptor 3 Homo sapiens <10 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648763 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648763&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 171362262 494493624 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370757 CCC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(NC(C)=O)cc2F)C1 InChI=1S/C24H26F2N4O3/c1-4-22(32)29-7-8-33-17(13-29)12-20-24(28-21-9-14(2)5-6-30(20)21)23-18(25)10-16(11-19(23)26)27-15(3)31/h5-6,9-11,17H,4,7-8,12-13H2,1-3H3,(H,27,31)/t17-/m0/s1 OMJZLAVUZAKCBQ-KRWDZBQOSA-N 648764 US20240034729, Compound 156 P2X purinoceptor 3 Homo sapiens <10 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648764 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648764&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 160035490 494493625 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370758 CCC(=O)N1CCO[C@@H](Cc2c(nc3cc(ccn23)C(F)F)-c2c(F)cc(NC(C)=O)cc2F)C1 InChI=1S/C24H24F4N4O3/c1-3-21(34)31-6-7-35-16(12-31)11-19-23(30-20-8-14(24(27)28)4-5-32(19)20)22-17(25)9-15(10-18(22)26)29-13(2)33/h4-5,8-10,16,24H,3,6-7,11-12H2,1-2H3,(H,29,33)/t16-/m0/s1 URTGACJLHWWJDU-INIZCTEOSA-N 648765 US20240034729, Compound 157 P2X purinoceptor 3 Homo sapiens <10 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648765 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648765&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 171362263 494493626 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370759 CC(=O)N1CCO[C@@H](Cc2c(nc3cc(Cl)ccn23)-c2c(F)cc(cc2F)-n2ccnc2)C1 InChI=1S/C23H20ClF2N5O2/c1-14(32)29-6-7-33-17(12-29)11-20-23(28-21-8-15(24)2-4-31(20)21)22-18(25)9-16(10-19(22)26)30-5-3-27-13-30/h2-5,8-10,13,17H,6-7,11-12H2,1H3/t17-/m0/s1 KKQOTHKVIRVGMS-KRWDZBQOSA-N 648766 US20240034729, Compound 158 P2X purinoceptor 3 Homo sapiens <10 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648766 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648766&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 154965190 494493627 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370760 CC(=O)N1CCO[C@@H](Cc2c(nc3cc(Cl)ccn23)-c2c(F)cc(cc2F)-c2ncco2)C1 InChI=1S/C23H19ClF2N4O3/c1-13(31)29-5-7-32-16(12-29)11-19-22(28-20-10-15(24)2-4-30(19)20)21-17(25)8-14(9-18(21)26)23-27-3-6-33-23/h2-4,6,8-10,16H,5,7,11-12H2,1H3/t16-/m0/s1 QRHFGBQMVZWYRJ-INIZCTEOSA-N 648767 US20240034729, Compound 159 P2X purinoceptor 3 Homo sapiens <10 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648767 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648767&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 153626468 494493628 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370761 CC(=O)N1CCO[C@@H](Cc2c(nc3cc(Cl)ccn23)-c2c(F)cc(cc2F)-n2cccn2)C1 InChI=1S/C23H20ClF2N5O2/c1-14(32)29-7-8-33-17(13-29)12-20-23(28-21-9-15(24)3-6-30(20)21)22-18(25)10-16(11-19(22)26)31-5-2-4-27-31/h2-6,9-11,17H,7-8,12-13H2,1H3/t17-/m0/s1 BSKLUKDPDPGSIF-KRWDZBQOSA-N 648768 US20240034729, Compound 160 P2X purinoceptor 3 Homo sapiens <10 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648768 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648768&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 156904786 494493629 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370762 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(Cl)ccn23)-c2c(F)cc(N)cc2F)C1 InChI=1S/C20H19ClF2N4O3/c1-29-20(28)26-4-5-30-13(10-26)9-16-19(18-14(22)7-12(24)8-15(18)23)25-17-6-11(21)2-3-27(16)17/h2-3,6-8,13H,4-5,9-10,24H2,1H3/t13-/m0/s1 ANNZWTVJMUUISY-ZDUSSCGKSA-N 648769 US20240034729, Compound 161 P2X purinoceptor 3 Homo sapiens <100 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648769 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648769&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 153626414 494493630 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370763 CC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(cc2F)-n2ccnc2)C1 InChI=1S/C24H23F2N5O2/c1-15-3-5-31-21(12-18-13-29(16(2)32)7-8-33-18)24(28-22(31)9-15)23-19(25)10-17(11-20(23)26)30-6-4-27-14-30/h3-6,9-11,14,18H,7-8,12-13H2,1-2H3/t18-/m0/s1 YVUWJDGVBLYUMP-SFHVURJKSA-N 648770 US20240034729, Compound 162 P2X purinoceptor 3 Homo sapiens <10 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648770 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648770&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 154965207 494493631 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370764 CC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(cc2F)-c2ncco2)C1 InChI=1S/C24H22F2N4O3/c1-14-3-5-30-20(12-17-13-29(15(2)31)6-8-32-17)23(28-21(30)9-14)22-18(25)10-16(11-19(22)26)24-27-4-7-33-24/h3-5,7,9-11,17H,6,8,12-13H2,1-2H3/t17-/m0/s1 ZWHMQLJHDKTSMO-KRWDZBQOSA-N 648771 US20240034729, Compound 163 P2X purinoceptor 3 Homo sapiens <10 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648771 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648771&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 154965259 494493632 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370765 CCC(=O)c1ccn(n1)-c1cc(F)c(-c2nc3cc(C)ccn3c2C[C@H]2CN(CCO2)C(=O)OC)c(F)c1 InChI=1S/C27H27F2N5O4/c1-4-23(35)21-6-8-34(31-21)17-12-19(28)25(20(29)13-17)26-22(33-7-5-16(2)11-24(33)30-26)14-18-15-32(9-10-38-18)27(36)37-3/h5-8,11-13,18H,4,9-10,14-15H2,1-3H3/t18-/m0/s1 VMAFGJCAGFDXBA-SFHVURJKSA-N 648772 US20240034729, Compound 164 P2X purinoceptor 3 Homo sapiens <100 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648772 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648772&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 153626359 494493633 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370766 CC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(cc2F)-c2nnc[nH]2)C1 648773 US20240034729, Compound 165 P2X purinoceptor 3 Homo sapiens <10 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648773 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648773&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 167370634 494493634 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370767 CC(=O)N1CCO[C@@H](Cc2c(nc3cc(Cl)ccn23)-c2c(F)cc(cc2F)-c2nnc[nH]2)C1 648774 US20240034729, Compound 166 P2X purinoceptor 3 Homo sapiens <10 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648774 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648774&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 167370674 494493635 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370768 CC(=O)Nc1cc(F)c(-c2nc3cc(C)ccn3c2C[C@H]2CN(CCO2)C(C)=O)c(F)c1 InChI=1S/C23H24F2N4O3/c1-13-4-5-29-20(11-17-12-28(15(3)31)6-7-32-17)23(27-21(29)8-13)22-18(24)9-16(10-19(22)25)26-14(2)30/h4-5,8-10,17H,6-7,11-12H2,1-3H3,(H,26,30)/t17-/m0/s1 GFHDOAHRGZFWEC-KRWDZBQOSA-N 648775 US20240034729, Compound 167 P2X purinoceptor 3 Homo sapiens <10 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648775 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648775&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 153626239 494493636 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370769 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2cnc(cc2C)-n2cccn2)C1 InChI=1S/C24H26N6O3/c1-16-5-8-29-20(13-18-15-28(9-10-33-18)24(31)32-3)23(27-22(29)11-16)19-14-25-21(12-17(19)2)30-7-4-6-26-30/h4-8,11-12,14,18H,9-10,13,15H2,1-3H3/t18-/m0/s1 YJMWPVPACYNVBN-SFHVURJKSA-N 648776 US20240034729, Compound 168 P2X purinoceptor 3 Homo sapiens <100 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648776 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648776&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 153626353 494493637 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370770 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(cc2F)N2CC=CC2=O)C1 InChI=1S/C25H24F2N4O4/c1-15-5-7-31-20(13-17-14-29(8-9-35-17)25(33)34-2)24(28-21(31)10-15)23-18(26)11-16(12-19(23)27)30-6-3-4-22(30)32/h3-5,7,10-12,17H,6,8-9,13-14H2,1-2H3/t17-/m0/s1 MJZMEZMJDUIZQK-KRWDZBQOSA-N 648777 US20240034729, Compound 169 P2X purinoceptor 3 Homo sapiens <10 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648777 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648777&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 154965282 494493638 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370771 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(NC(=O)CC(C)C(N)=O)cc2F)C1 InChI=1S/C26H29F2N5O5/c1-14-4-5-33-20(12-17-13-32(6-7-38-17)26(36)37-3)24(31-21(33)8-14)23-18(27)10-16(11-19(23)28)30-22(34)9-15(2)25(29)35/h4-5,8,10-11,15,17H,6-7,9,12-13H2,1-3H3,(H2,29,35)(H,30,34)/t15?,17-/m0/s1 WNRQRQAQIWULIO-LWKPJOBUSA-N 648778 US20240034729, Compound 170 P2X purinoceptor 3 Homo sapiens <1000 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648778 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648778&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 166774825 494493639 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370772 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(cc2F)S(N)(=O)=O)C1 InChI=1S/C21H22F2N4O5S/c1-12-3-4-27-17(8-13-11-26(5-6-32-13)21(28)31-2)20(25-18(27)7-12)19-15(22)9-14(10-16(19)23)33(24,29)30/h3-4,7,9-10,13H,5-6,8,11H2,1-2H3,(H2,24,29,30)/t13-/m0/s1 JFCGMCRZKHFCAX-ZDUSSCGKSA-N 648779 US20240034729, Compound 171 P2X purinoceptor 3 Homo sapiens 2.10 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648779 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648779&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 153626477 494493640 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370773 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(Cl)ccn23)-c2c(F)cc(cc2F)S(N)(=O)=O)C1 InChI=1S/C20H19ClF2N4O5S/c1-31-20(28)26-4-5-32-12(10-26)7-16-19(25-17-6-11(21)2-3-27(16)17)18-14(22)8-13(9-15(18)23)33(24,29)30/h2-3,6,8-9,12H,4-5,7,10H2,1H3,(H2,24,29,30)/t12-/m0/s1 LCFJBSQSNPDSIX-LBPRGKRZSA-N 648780 US20240034729, Compound 172 P2X purinoceptor 3 Homo sapiens 0.700 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648780 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648780&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 153626314 494493641 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370774 CC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(cc2F)S(N)(=O)=O)C1 InChI=1S/C21H22F2N4O4S/c1-12-3-4-27-18(8-14-11-26(13(2)28)5-6-31-14)21(25-19(27)7-12)20-16(22)9-15(10-17(20)23)32(24,29)30/h3-4,7,9-10,14H,5-6,8,11H2,1-2H3,(H2,24,29,30)/t14-/m0/s1 GMJOLPUFMHYQKZ-AWEZNQCLSA-N 648781 US20240034729, Compound 173 P2X purinoceptor 3 Homo sapiens 1.80 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648781 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648781&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 153626225 494493642 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370775 CC(=O)N1CCO[C@@H](Cc2c(nc3cc(Cl)ccn23)-c2c(F)cc(cc2F)S(N)(=O)=O)C1 InChI=1S/C20H19ClF2N4O4S/c1-11(28)26-4-5-31-13(10-26)7-17-20(25-18-6-12(21)2-3-27(17)18)19-15(22)8-14(9-16(19)23)32(24,29)30/h2-3,6,8-9,13H,4-5,7,10H2,1H3,(H2,24,29,30)/t13-/m0/s1 SGZBVTSABWENRO-ZDUSSCGKSA-N 648782 US20240034729, Compound 174 P2X purinoceptor 3 Homo sapiens 1.60 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648782 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648782&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 153626354 494493643 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370776 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(cc2F)S(C)(=O)=O)C1 InChI=1S/C22H23F2N3O5S/c1-13-4-5-27-18(9-14-12-26(6-7-32-14)22(28)31-2)21(25-19(27)8-13)20-16(23)10-15(11-17(20)24)33(3,29)30/h4-5,8,10-11,14H,6-7,9,12H2,1-3H3/t14-/m0/s1 AARGMYZSJSAWJZ-AWEZNQCLSA-N 648783 US20240034729, Compound 175 P2X purinoceptor 3 Homo sapiens >10000 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648783 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648783&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 153626373 494493644 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370777 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2ccc(cc2Cl)S(N)(=O)=O)C1 InChI=1S/C21H23ClN4O5S/c1-13-5-6-26-18(10-14-12-25(7-8-31-14)21(27)30-2)20(24-19(26)9-13)16-4-3-15(11-17(16)22)32(23,28)29/h3-6,9,11,14H,7-8,10,12H2,1-2H3,(H2,23,28,29)/t14-/m0/s1 SIOCHZFWHSFOAO-AWEZNQCLSA-N 648784 US20240034729, Compound 176 P2X purinoceptor 3 Homo sapiens 7.50 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648784 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648784&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 153626283 494493645 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370778 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(cc2Cl)S(N)(=O)=O)C1 InChI=1S/C21H22ClFN4O5S/c1-12-3-4-27-17(8-13-11-26(5-6-32-13)21(28)31-2)20(25-18(27)7-12)19-15(22)9-14(10-16(19)23)33(24,29)30/h3-4,7,9-10,13H,5-6,8,11H2,1-2H3,(H2,24,29,30)/t13-/m0/s1 DEFYWSYWYJLDRG-ZDUSSCGKSA-N 648785 US20240034729, Compound 177 P2X purinoceptor 3 Homo sapiens 1.10 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648785 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648785&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 153626248 494493646 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370779 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(Cl)ccn23)-c2ccc(cc2Cl)S(N)(=O)=O)C1 InChI=1S/C20H20Cl2N4O5S/c1-30-20(27)25-6-7-31-13(11-25)9-17-19(24-18-8-12(21)4-5-26(17)18)15-3-2-14(10-16(15)22)32(23,28)29/h2-5,8,10,13H,6-7,9,11H2,1H3,(H2,23,28,29)/t13-/m0/s1 WISRCAKMWVTABD-ZDUSSCGKSA-N 648786 US20240034729, Compound 178 P2X purinoceptor 3 Homo sapiens 0.100 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648786 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648786&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 153626310 494493647 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370780 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(Cl)ccn23)-c2c(F)cc(cc2Cl)S(N)(=O)=O)C1 InChI=1S/C20H19Cl2FN4O5S/c1-31-20(28)26-4-5-32-12(10-26)7-16-19(25-17-6-11(21)2-3-27(16)17)18-14(22)8-13(9-15(18)23)33(24,29)30/h2-3,6,8-9,12H,4-5,7,10H2,1H3,(H2,24,29,30)/t12-/m0/s1 JLEIKHGGNBVZTH-LBPRGKRZSA-N 648787 US20240034729, Compound 179 P2X purinoceptor 3 Homo sapiens 0.400 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648787 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648787&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 153626422 494493648 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370781 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2cc(F)c(cc2Cl)S(N)(=O)=O)C1 InChI=1S/C21H22ClFN4O5S/c1-12-3-4-27-17(8-13-11-26(5-6-32-13)21(28)31-2)20(25-19(27)7-12)14-9-16(23)18(10-15(14)22)33(24,29)30/h3-4,7,9-10,13H,5-6,8,11H2,1-2H3,(H2,24,29,30)/t13-/m0/s1 ZZMQZORTFFWZNB-ZDUSSCGKSA-N 648788 US20240034729, Compound 180 P2X purinoceptor 3 Homo sapiens 0.200 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648788 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648788&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 153626304 494493649 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370782 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(Cl)ccn23)-c2cc(F)c(cc2Cl)S(N)(=O)=O)C1 InChI=1S/C20H19Cl2FN4O5S/c1-31-20(28)26-4-5-32-12(10-26)7-16-19(25-18-6-11(21)2-3-27(16)18)13-8-15(23)17(9-14(13)22)33(24,29)30/h2-3,6,8-9,12H,4-5,7,10H2,1H3,(H2,24,29,30)/t12-/m0/s1 LOWQBHKMLRFCPW-LBPRGKRZSA-N 648789 US20240034729, Compound 181 P2X purinoceptor 3 Homo sapiens 1.80 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648789 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648789&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 153626441 494493650 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370783 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)c(F)cn23)-c2c(F)cc(cc2F)S(N)(=O)=O)C1 InChI=1S/C21H21F3N4O5S/c1-11-5-18-26-20(19-14(22)7-13(8-15(19)23)34(25,30)31)17(28(18)10-16(11)24)6-12-9-27(3-4-33-12)21(29)32-2/h5,7-8,10,12H,3-4,6,9H2,1-2H3,(H2,25,30,31)/t12-/m0/s1 MEPQUVGRRSZIPQ-LBPRGKRZSA-N 648790 US20240034729, Compound 182 P2X purinoceptor 3 Homo sapiens 3.50 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648790 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648790&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 153626282 494493651 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370784 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(Cl)c(F)cn23)-c2c(F)cc(cc2F)S(N)(=O)=O)C1 InChI=1S/C20H18ClF3N4O5S/c1-32-20(29)27-2-3-33-10(8-27)4-16-19(26-17-7-12(21)15(24)9-28(16)17)18-13(22)5-11(6-14(18)23)34(25,30)31/h5-7,9-10H,2-4,8H2,1H3,(H2,25,30,31)/t10-/m0/s1 XDDBDVRJGBHERW-JTQLQIEISA-N 648791 US20240034729, Compound 183 P2X purinoceptor 3 Homo sapiens 5.50 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648791 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648791&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 153626320 494493652 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370785 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2ccc(cc2C)S(N)(=O)=O)C1 InChI=1S/C22H26N4O5S/c1-14-6-7-26-19(12-16-13-25(8-9-31-16)22(27)30-3)21(24-20(26)10-14)18-5-4-17(11-15(18)2)32(23,28)29/h4-7,10-11,16H,8-9,12-13H2,1-3H3,(H2,23,28,29)/t16-/m0/s1 MYYQUMQUXPFCGP-INIZCTEOSA-N 648792 US20240034729, Compound 184 P2X purinoceptor 3 Homo sapiens 5.60 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648792 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648792&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 153626328 494493653 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370786 CNC(=O)c1ccnc(Cc2c(nc3cc(C)ccn23)-c2c(F)cc(cc2F)S(N)(=O)=O)c1 InChI=1S/C22H19F2N5O3S/c1-12-4-6-29-18(9-14-8-13(3-5-27-14)22(30)26-2)21(28-19(29)7-12)20-16(23)10-15(11-17(20)24)33(25,31)32/h3-8,10-11H,9H2,1-2H3,(H,26,30)(H2,25,31,32) VTKPIYAOSRSCFH-UHFFFAOYSA-N 648793 US20240034729, Compound 185 P2X purinoceptor 3 Homo sapiens 13.0 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648793 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648793&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 154965034 494493654 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370787 Cc1ccn2c(Cc3cc(ccn3)C#N)c(nc2c1)-c1c(F)cc(cc1F)S(N)(=O)=O InChI=1S/C21H15F2N5O2S/c1-12-3-5-28-18(8-14-7-13(11-24)2-4-26-14)21(27-19(28)6-12)20-16(22)9-15(10-17(20)23)31(25,29)30/h2-7,9-10H,8H2,1H3,(H2,25,29,30) XKOHZZNPUWLLKH-UHFFFAOYSA-N 648794 US20240034729, Compound 186 P2X purinoceptor 3 Homo sapiens 65.0 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648794 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648794&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 154965037 494493655 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370788 COC(=O)N1CCC[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(cc2F)S(N)(=O)=O)C1 InChI=1S/C22H24F2N4O4S/c1-13-5-7-28-18(9-14-4-3-6-27(12-14)22(29)32-2)21(26-19(28)8-13)20-16(23)10-15(11-17(20)24)33(25,30)31/h5,7-8,10-11,14H,3-4,6,9,12H2,1-2H3,(H2,25,30,31)/t14-/m0/s1 LPRYKLXBVXUPIJ-AWEZNQCLSA-N 648795 US20240034729, Compound 187 P2X purinoceptor 3 Homo sapiens 50.0 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648795 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648795&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 154965035 494493656 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370789 COC(=O)N1CCC[C@@H](Cc2c(nc3cc(Cl)ccn23)-c2c(F)cc(cc2F)S(N)(=O)=O)C1 InChI=1S/C21H21ClF2N4O4S/c1-32-21(29)27-5-2-3-12(11-27)7-17-20(26-18-8-13(22)4-6-28(17)18)19-15(23)9-14(10-16(19)24)33(25,30)31/h4,6,8-10,12H,2-3,5,7,11H2,1H3,(H2,25,30,31)/t12-/m0/s1 MNBJKHXRVWZQPA-LBPRGKRZSA-N 648796 US20240034729, Compound 188 P2X purinoceptor 3 Homo sapiens 9.00 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648796 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648796&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 154965036 494493657 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370790 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2ccc(cc2C(F)(F)F)S(N)(=O)=O)C1 InChI=1S/C22H23F3N4O5S/c1-13-5-6-29-18(10-14-12-28(7-8-34-14)21(30)33-2)20(27-19(29)9-13)16-4-3-15(35(26,31)32)11-17(16)22(23,24)25/h3-6,9,11,14H,7-8,10,12H2,1-2H3,(H2,26,31,32)/t14-/m0/s1 QZCXRPLXIPJKGN-AWEZNQCLSA-N 648797 US20240034729, Compound 189 P2X purinoceptor 3 Homo sapiens 10.00 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648797 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648797&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 153626351 494493658 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370791 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2ccc(nc2Cl)S(N)(=O)=O)C1 InChI=1S/C20H22ClN5O5S/c1-12-5-6-26-15(10-13-11-25(7-8-31-13)20(27)30-2)18(23-16(26)9-12)14-3-4-17(24-19(14)21)32(22,28)29/h3-6,9,13H,7-8,10-11H2,1-2H3,(H2,22,28,29)/t13-/m0/s1 IGFHMMOCRAIETD-ZDUSSCGKSA-N 648798 US20240034729, Compound 190 P2X purinoceptor 3 Homo sapiens <10 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648798 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648798&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 166774838 494493659 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370792 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2ncc(nc2Cl)S(N)(=O)=O)C1 InChI=1S/C19H21ClN6O5S/c1-11-3-4-26-13(8-12-10-25(5-6-31-12)19(27)30-2)16(23-14(26)7-11)17-18(20)24-15(9-22-17)32(21,28)29/h3-4,7,9,12H,5-6,8,10H2,1-2H3,(H2,21,28,29)/t12-/m0/s1 KUFVOGCMYNTJFQ-LBPRGKRZSA-N 648799 US20240034729, Compound 191 P2X purinoceptor 3 Homo sapiens <10 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648799 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648799&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 154965033 494493660 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370793 COC(=O)N1CCO[C@@H](Cc2c(nc3cc(C)ccn23)-c2c(F)cc(cc2F)-n2cnc(c2)C#N)C1 InChI=1S/C25H22F2N6O3/c1-15-3-4-33-21(10-18-13-31(5-6-36-18)25(34)35-2)24(30-22(33)7-15)23-19(26)8-17(9-20(23)27)32-12-16(11-28)29-14-32/h3-4,7-9,12,14,18H,5-6,10,13H2,1-2H3/t18-/m0/s1 GFCMAOKIBUTDJS-SFHVURJKSA-N 648800 US20240034729, Compound 192 P2X purinoceptor 3 Homo sapiens <100 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648800 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648800&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 153626281 494493661 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370794 CNC(=O)c1cc(F)c(-c2nc3cc(C)ccn3c2C[C@H]2CN(CCO2)C(=O)OC)c(F)c1 InChI=1S/C23H24F2N4O4/c1-13-4-5-29-18(11-15-12-28(6-7-33-15)23(31)32-3)21(27-19(29)8-13)20-16(24)9-14(10-17(20)25)22(30)26-2/h4-5,8-10,15H,6-7,11-12H2,1-3H3,(H,26,30)/t15-/m0/s1 SEHLMRJSQFAPCJ-HNNXBMFYSA-N 648801 US20240034729, Positive compound 1 P2X purinoceptor 3 Homo sapiens 11.5 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=648801 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=648801&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 76955630 494493662 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1370795 COc1cc(C(C)C)c(Oc2cnc(N)nc2N)cc1S(N)(=O)=O InChI=1S/C14H19N5O4S/c1-7(2)8-4-10(22-3)12(24(17,20)21)5-9(8)23-11-6-18-14(16)19-13(11)15/h4-7H,1-3H3,(H2,17,20,21)(H4,15,16,18,19) HLWURFKMDLAKOD-UHFFFAOYSA-N 50533006 Af-219::Gefapixant::R-1646::R1646::RG-1646::RG1646::RO-4926219::RO4926219::US20240034729, Positive compound 2 P2X purinoceptor 3 Homo sapiens 52.2 US Patent 10.7270/Q27M0D39 US20240034729 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C Wuhan Ll Science and Technology Development Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533006 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533006&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search AF9 5YVE 24764487 440741588 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1384958 CC(C)c1c[n+]([O-])c(Br)cc1Oc1cnc(N)nc1N InChI=1S/C12H14BrN5O2/c1-6(2)7-5-18(19)10(13)3-8(7)20-9-4-16-12(15)17-11(9)14/h3-6H,1-2H3,(H4,14,15,16,17) RYWBHQSNRVBILZ-UHFFFAOYSA-N 656868 2-bromo-4- ((2,4- diaminopyrimidin- 5-yl)oxy)-5- isopropylpyridine 1-oxide::US11919918, Compound C1 P2X purinoceptor 3 Homo sapiens 746 US Patent 10.7270/Q24F1W1X US11919918 Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F BEIJING TIDE PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656868 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656868&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155124122 496175934 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1384959 CC(C)c1cnc(Br)cc1Oc1cnc(N)nc1N InChI=1S/C12H14BrN5O/c1-6(2)7-4-16-10(13)3-8(7)19-9-5-17-12(15)18-11(9)14/h3-6H,1-2H3,(H4,14,15,17,18) KVMKNPHEMHTMED-UHFFFAOYSA-N 656869 US11919918, Compound C2 P2X purinoceptor 3 Homo sapiens 88.1 US Patent 10.7270/Q24F1W1X US11919918 Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F BEIJING TIDE PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656869 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656869&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 142576033 496175935 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1384960 CC(C)c1cnc(Cl)cc1Oc1cnc(N)nc1N InChI=1S/C12H14ClN5O/c1-6(2)7-4-16-10(13)3-8(7)19-9-5-17-12(15)18-11(9)14/h3-6H,1-2H3,(H4,14,15,17,18) AGSPLJZFKPBSFH-UHFFFAOYSA-N 656870 US11919918, Compound C3 P2X purinoceptor 3 Homo sapiens 205 US Patent 10.7270/Q24F1W1X US11919918 Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F BEIJING TIDE PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656870 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656870&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 146940256 496175936 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1384961 COc1cc(Oc2cnc(N)nc2N)c(cn1)C(C)C InChI=1S/C13H17N5O2/c1-7(2)8-5-16-11(19-3)4-9(8)20-10-6-17-13(15)18-12(10)14/h4-7H,1-3H3,(H4,14,15,17,18) YIFDMDASOQQQCR-UHFFFAOYSA-N 656871 US11919918, Compound C4 P2X purinoceptor 3 Homo sapiens 102 US Patent 10.7270/Q24F1W1X US11919918 Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F BEIJING TIDE PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656871 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656871&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 142576048 496175937 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1384962 CC(C)c1cnc(cc1Oc1cnc(N)nc1N)S(N)(=O)=O InChI=1S/C12H16N6O3S/c1-6(2)7-4-16-10(22(15,19)20)3-8(7)21-9-5-17-12(14)18-11(9)13/h3-6H,1-2H3,(H2,15,19,20)(H4,13,14,17,18) JQNLBDUSVQEXRZ-UHFFFAOYSA-N 656877 US11919918, Compound C6 P2X purinoceptor 3 Homo sapiens 348 US Patent 10.7270/Q24F1W1X US11919918 Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F BEIJING TIDE PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656877 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656877&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 142576056 496175943 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1384963 CC(C)c1cnc(C)cc1Oc1cnc(N)nc1N InChI=1S/C13H17N5O/c1-7(2)9-5-16-8(3)4-10(9)19-11-6-17-13(15)18-12(11)14/h4-7H,1-3H3,(H4,14,15,17,18) WHXGJYHUGMGUEJ-UHFFFAOYSA-N 656878 US11919918, Compound C9 P2X purinoceptor 3 Homo sapiens 254 US Patent 10.7270/Q24F1W1X US11919918 Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F BEIJING TIDE PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656878 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656878&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 142576027 496175944 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1384964 CC(C)c1ncc(Cl)cc1Oc1cnc(N)nc1N InChI=1S/C12H14ClN5O/c1-6(2)10-8(3-7(13)4-16-10)19-9-5-17-12(15)18-11(9)14/h3-6H,1-2H3,(H4,14,15,17,18) GWRKJESGDZRWLP-UHFFFAOYSA-N 656879 US11919918, Compound C10 P2X purinoceptor 3 Homo sapiens 2507 US Patent 10.7270/Q24F1W1X US11919918 Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F BEIJING TIDE PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656879 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656879&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 142576067 496175945 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1384965 CC(C)c1cnc(I)cc1Oc1cnc(N)nc1N InChI=1S/C12H14IN5O/c1-6(2)7-4-16-10(13)3-8(7)19-9-5-17-12(15)18-11(9)14/h3-6H,1-2H3,(H4,14,15,17,18) LLLJBGAVSRMERV-UHFFFAOYSA-N 656880 US11919918, Compound C12 P2X purinoceptor 3 Homo sapiens 73.6 US Patent 10.7270/Q24F1W1X US11919918 Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F BEIJING TIDE PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656880&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 148366362 496175946 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1384966 CC(C)c1cnc(cc1Oc1cnc(N)nc1N)-c1ccccc1 InChI=1S/C18H19N5O/c1-11(2)13-9-21-14(12-6-4-3-5-7-12)8-15(13)24-16-10-22-18(20)23-17(16)19/h3-11H,1-2H3,(H4,19,20,22,23) OBGPSFYWTMIERK-UHFFFAOYSA-N 656881 5-(5- isopropyl-2- phenylpyridin-4- yl)oxy)pyrimidine- 2,4-diamine::US11919918, Compound C13 P2X purinoceptor 3 Homo sapiens 355 US Patent 10.7270/Q24F1W1X US11919918 Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F BEIJING TIDE PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656881 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656881&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 148732594 496175947 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1384967 CCc1cc(Oc2cnc(N)nc2N)c(cn1)C(C)C InChI=1S/C14H19N5O/c1-4-9-5-11(10(6-17-9)8(2)3)20-12-7-18-14(16)19-13(12)15/h5-8H,4H2,1-3H3,(H4,15,16,18,19) ZQDHWIRHCQDPAE-UHFFFAOYSA-N 656882 US11919918, Compound C15 P2X purinoceptor 3 Homo sapiens 307 US Patent 10.7270/Q24F1W1X US11919918 Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F BEIJING TIDE PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656882 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656882&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 142576028 496175948 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1384968 CC(C)c1cc(Oc2cnc(N)nc2N)c(cn1)C(C)C InChI=1S/C15H21N5O/c1-8(2)10-6-18-11(9(3)4)5-12(10)21-13-7-19-15(17)20-14(13)16/h5-9H,1-4H3,(H4,16,17,19,20) TVJYSXAHLMUWKQ-UHFFFAOYSA-N 656883 US11919918, Compound C16 P2X purinoceptor 3 Homo sapiens 802 US Patent 10.7270/Q24F1W1X US11919918 Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F BEIJING TIDE PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656883 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656883&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 142576042 496175949 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1384969 CSc1cc(Oc2cnc(N)nc2N)c(cn1)C(C)C InChI=1S/C13H17N5OS/c1-7(2)8-5-16-11(20-3)4-9(8)19-10-6-17-13(15)18-12(10)14/h4-7H,1-3H3,(H4,14,15,17,18) BXXIYYYYYVIZGF-UHFFFAOYSA-N 656884 US11919918, Compound C20 P2X purinoceptor 3 Homo sapiens 44.4 US Patent 10.7270/Q24F1W1X US11919918 Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F BEIJING TIDE PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656884 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656884&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 142576038 496175950 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1384970 CC(C)c1cnc(N)cc1Oc1cnc(N)nc1N InChI=1S/C12H16N6O/c1-6(2)7-4-16-10(13)3-8(7)19-9-5-17-12(15)18-11(9)14/h3-6H,1-2H3,(H2,13,16)(H4,14,15,17,18) ODNZBUXEQRISGA-UHFFFAOYSA-N 656885 US11919918, Compound C21 P2X purinoceptor 3 Homo sapiens 131 US Patent 10.7270/Q24F1W1X US11919918 Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F BEIJING TIDE PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656885 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656885&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 142576065 496175951 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1384971 CNc1cc(Oc2cnc(N)nc2N)c(cn1)C(C)C InChI=1S/C13H18N6O/c1-7(2)8-5-17-11(16-3)4-9(8)20-10-6-18-13(15)19-12(10)14/h4-7H,1-3H3,(H,16,17)(H4,14,15,18,19) PEHVVBHHSDSXRU-UHFFFAOYSA-N 656886 US11919918, Compound C22 P2X purinoceptor 3 Homo sapiens 37.0 US Patent 10.7270/Q24F1W1X US11919918 Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F BEIJING TIDE PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656886 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656886&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 142576050 496175952 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1384972 CC(C)c1cnc(cc1Oc1cnc(N)nc1N)N(C)C InChI=1S/C14H20N6O/c1-8(2)9-6-17-12(20(3)4)5-10(9)21-11-7-18-14(16)19-13(11)15/h5-8H,1-4H3,(H4,15,16,18,19) OAHSCRYMJYQLQT-UHFFFAOYSA-N 656887 US11919918, Compound C23 P2X purinoceptor 3 Homo sapiens 365 US Patent 10.7270/Q24F1W1X US11919918 Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F BEIJING TIDE PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656887 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656887&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 142576041 496175953 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1384973 COc1cc(Oc2cnc(N)nc2N)c(cn1)C1CC1 InChI=1S/C13H15N5O2/c1-19-11-4-9(8(5-16-11)7-2-3-7)20-10-6-17-13(15)18-12(10)14/h4-7H,2-3H2,1H3,(H4,14,15,17,18) SUVDLCJLJDKSND-UHFFFAOYSA-N 656888 5-((5- cyclopropyl-2- methoxypyridin- 4-yl)oxy) pyrimidine- 2,4-diamine::US11919918, Compound C33 P2X purinoceptor 3 Homo sapiens 238 US Patent 10.7270/Q24F1W1X US11919918 Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F BEIJING TIDE PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656888 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656888&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155124170 496175954 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1384974 CC(C)c1cnc(cc1Oc1cnc(N)nc1N)-c1cn[nH]c1 InChI=1S/C15H17N7O/c1-8(2)10-6-18-11(9-4-20-21-5-9)3-12(10)23-13-7-19-15(17)22-14(13)16/h3-8H,1-2H3,(H,20,21)(H4,16,17,19,22) FMHUWFCQINDZEE-UHFFFAOYSA-N 656889 5-((5- isopropyl-2- (1H-pyrazol-4- yl)pyridin-4- yl)oxy) pyrimidine- 2,4-diamine::US11919918, Compound C35 P2X purinoceptor 3 Homo sapiens 1167 US Patent 10.7270/Q24F1W1X US11919918 Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F BEIJING TIDE PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656889 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656889&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 147527117 496175955 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1384975 CC(C)c1cnc(cc1Oc1cnc(N)nc1N)-n1cccc1 InChI=1S/C16H18N6O/c1-10(2)11-8-19-14(22-5-3-4-6-22)7-12(11)23-13-9-20-16(18)21-15(13)17/h3-10H,1-2H3,(H4,17,18,20,21) NEPWUPRDKXUFHD-UHFFFAOYSA-N 656890 5-((5- isopropyl-2- (1H-pyrrol-1- yl)pyridin-4- yl)oxy) pyrimidine- 2,4-diamine::US11919918, Compound C38 P2X purinoceptor 3 Homo sapiens 787 US Patent 10.7270/Q24F1W1X US11919918 Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F BEIJING TIDE PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656890 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656890&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 148612327 496175956 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1384976 CC(C)c1cnc(cc1Oc1cnc(N)nc1N)-c1ccco1 InChI=1S/C16H17N5O2/c1-9(2)10-7-19-11(12-4-3-5-22-12)6-13(10)23-14-8-20-16(18)21-15(14)17/h3-9H,1-2H3,(H4,17,18,20,21) MFKZQPIHSOOHCF-UHFFFAOYSA-N 656891 5-((2-(furan-2- yl)-5- isopropylpyridin- 4-yl)oxy) pyrimidine- 2,4-diamine::US11919918, Compound C39 P2X purinoceptor 3 Homo sapiens 166 US Patent 10.7270/Q24F1W1X US11919918 Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F BEIJING TIDE PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656891 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656891&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 148473507 496175957 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1384977 CC(C)c1cnc(SCc2ccccc2)cc1Oc1cnc(N)nc1N InChI=1S/C19H21N5OS/c1-12(2)14-9-22-17(26-11-13-6-4-3-5-7-13)8-15(14)25-16-10-23-19(21)24-18(16)20/h3-10,12H,11H2,1-2H3,(H4,20,21,23,24) GZILKSCCDYMJFU-UHFFFAOYSA-N 656892 US11919918, Compound C41 P2X purinoceptor 3 Homo sapiens 1854 US Patent 10.7270/Q24F1W1X US11919918 Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F BEIJING TIDE PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656892 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656892&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 147735778 496175958 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1384978 CC(C)c1cnc(C=C)cc1Oc1cnc(N)nc1N InChI=1S/C14H17N5O/c1-4-9-5-11(10(6-17-9)8(2)3)20-12-7-18-14(16)19-13(12)15/h4-8H,1H2,2-3H3,(H4,15,16,18,19) KKRLDNGHTZSISE-UHFFFAOYSA-N 656893 5-(5- isopropyl-2- vinylpyridin-4- yl)oxy)pyrimidine- 2,4-diamine::US11919918, Compound C43 P2X purinoceptor 3 Homo sapiens 55.0 US Patent 10.7270/Q24F1W1X US11919918 Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F BEIJING TIDE PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656893 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656893&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 148214766 496175959 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1384979 CC(C)c1cnc(cc1Oc1cnc(N)nc1N)C(C)=C InChI=1S/C15H19N5O/c1-8(2)10-6-18-11(9(3)4)5-12(10)21-13-7-19-15(17)20-14(13)16/h5-8H,3H2,1-2,4H3,(H4,16,17,19,20) WIROOCGHVUYFNW-UHFFFAOYSA-N 656894 5-(5- isopropyl-2- (prop-1-en-2- yl)pyridin-4- yl)oxy)pyrimidine- 2,4-diamine::US11919918, Compound C44 P2X purinoceptor 3 Homo sapiens 116 US Patent 10.7270/Q24F1W1X US11919918 Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F BEIJING TIDE PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656894 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656894&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 153194404 496175960 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1384980 CCOC(=C)c1cc(Oc2cnc(N)nc2N)c(cn1)C(C)C InChI=1S/C16H21N5O2/c1-5-22-10(4)12-6-13(11(7-19-12)9(2)3)23-14-8-20-16(18)21-15(14)17/h6-9H,4-5H2,1-3H3,(H4,17,18,20,21) XYKDTSPZNVVSEB-UHFFFAOYSA-N 656895 5-((2-(1- ethoxyvinyl)-5- isopropylpyridin- 4-yl)oxy) pyrimidine- 2,4-diamine::US11919918, Compound C45 P2X purinoceptor 3 Homo sapiens 435 US Patent 10.7270/Q24F1W1X US11919918 Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F BEIJING TIDE PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656895 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656895&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 149309877 496175961 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1384981 CC(C)c1cnc(cc1Oc1cnc(N)nc1N)C1CC1 InChI=1S/C15H19N5O/c1-8(2)10-6-18-11(9-3-4-9)5-12(10)21-13-7-19-15(17)20-14(13)16/h5-9H,3-4H2,1-2H3,(H4,16,17,19,20) WVZOUPADCCZQPF-UHFFFAOYSA-N 656896 5-((2- cyclopropyl-5- isopropylpyridin- 4-yl)oxy) pyrimidine- 2,4-diamine::US11919918, Compound C52 P2X purinoceptor 3 Homo sapiens 147 US Patent 10.7270/Q24F1W1X US11919918 Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F BEIJING TIDE PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656896 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656896&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 153265026 496175962 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1384982 CCN(C)c1cc(Oc2cnc(N)nc2N)c(cn1)C(C)C InChI=1S/C15H22N6O/c1-5-21(4)13-6-11(10(7-18-13)9(2)3)22-12-8-19-15(17)20-14(12)16/h6-9H,5H2,1-4H3,(H4,16,17,19,20) PUOXAMUKBKHYHP-UHFFFAOYSA-N 656897 5-((2- (ethyl(methyl) amino)-5- isopropylpyridin- 4-yl)oxy)pyrimidine- 2,4-diamine::US11919918, Compound C61 P2X purinoceptor 3 Homo sapiens 274 US Patent 10.7270/Q24F1W1X US11919918 Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F BEIJING TIDE PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656897 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656897&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 148974782 496175963 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1384983 CC(C)c1cnc(cc1Oc1cnc(N)nc1N)N(C)C1CC1 InChI=1S/C16H22N6O/c1-9(2)11-7-19-14(22(3)10-4-5-10)6-12(11)23-13-8-20-16(18)21-15(13)17/h6-10H,4-5H2,1-3H3,(H4,17,18,20,21) OXAANSGVXLISAN-UHFFFAOYSA-N 656898 5-((2- (cyclopropyl (methyl)amino)- 5-isopropylpyridin- 4-yl)oxy) pyrimidine- 2,4-diamine::US11919918, Compound C65 P2X purinoceptor 3 Homo sapiens 334 US Patent 10.7270/Q24F1W1X US11919918 Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F BEIJING TIDE PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656898 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656898&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 148848829 496175964 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1384984 CC(C)c1cnc(cc1Oc1cnc(N)nc1N)C#C InChI=1S/C14H15N5O/c1-4-9-5-11(10(6-17-9)8(2)3)20-12-7-18-14(16)19-13(12)15/h1,5-8H,2-3H3,(H4,15,16,18,19) TZHOVNUCGUXMCS-UHFFFAOYSA-N 656899 US11919918, Compound C66 P2X purinoceptor 3 Homo sapiens 85.0 US Patent 10.7270/Q24F1W1X US11919918 Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F BEIJING TIDE PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656899 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656899&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 142576053 496175965 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1384985 CC(C)c1cnc(cc1Oc1cnc(N)nc1N)C(F)(F)F InChI=1S/C13H14F3N5O/c1-6(2)7-4-19-10(13(14,15)16)3-8(7)22-9-5-20-12(18)21-11(9)17/h3-6H,1-2H3,(H4,17,18,20,21) JWASUEMWYSDXET-UHFFFAOYSA-N 656900 US11919918, Compound C67 P2X purinoceptor 3 Homo sapiens 490 US Patent 10.7270/Q24F1W1X US11919918 Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F BEIJING TIDE PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656900 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656900&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 148136296 496175966 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1384986 CC(C)c1cnc(Br)cc1Oc1cnc(N)nc1NCCN(C)C InChI=1S/C16H23BrN6O/c1-10(2)11-8-20-14(17)7-12(11)24-13-9-21-16(18)22-15(13)19-5-6-23(3)4/h7-10H,5-6H2,1-4H3,(H3,18,19,21,22) NTYGXVZTWUAHKY-UHFFFAOYSA-N 656901 5-((2-bromo-5- isopropylpyridin- 4-yl)oxy)-N4-(2- (dimethylamino) ethyl)pyrimidine- 2,4-diamine::US11919918, Compound C71 P2X purinoceptor 3 Homo sapiens 72.0 US Patent 10.7270/Q24F1W1X US11919918 Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F BEIJING TIDE PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656901 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656901&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 151258931 496175967 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1384987 CSc1cc(Oc2cnc(N)nc2NCCN(C)C)c(cn1)C(C)C InChI=1S/C17H26N6OS/c1-11(2)12-9-20-15(25-5)8-13(12)24-14-10-21-17(18)22-16(14)19-6-7-23(3)4/h8-11H,6-7H2,1-5H3,(H3,18,19,21,22) FECARLDMQZFILK-UHFFFAOYSA-N 656902 US11919918, Compound C72 P2X purinoceptor 3 Homo sapiens 127 US Patent 10.7270/Q24F1W1X US11919918 Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F BEIJING TIDE PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656902 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656902&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 150145142 496175968 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1384988 CC(C)c1cnc(Cl)cc1Sc1cnc(N)nc1N InChI=1S/C12H14ClN5S/c1-6(2)7-4-16-10(13)3-8(7)19-9-5-17-12(15)18-11(9)14/h3-6H,1-2H3,(H4,14,15,17,18) MKNMLTBPGWDXSU-UHFFFAOYSA-N 656903 5-((2-chloro-5- isopropylpyridin- 4- yl)thio)pyrimidine- 2,4-diamine::US11919918, Compound C84 P2X purinoceptor 3 Homo sapiens 536 US Patent 10.7270/Q24F1W1X US11919918 Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F BEIJING TIDE PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656903 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656903&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 148500388 496175969 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1384989 CC(C)c1cnc(Br)cc1Sc1cnc(N)nc1N InChI=1S/C12H14BrN5S/c1-6(2)7-4-16-10(13)3-8(7)19-9-5-17-12(15)18-11(9)14/h3-6H,1-2H3,(H4,14,15,17,18) JQUPJHIEDALLMO-UHFFFAOYSA-N 656904 US11919918, Compound C85 P2X purinoceptor 3 Homo sapiens 78.0 US Patent 10.7270/Q24F1W1X US11919918 Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F BEIJING TIDE PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656904 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656904&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 142576051 496175970 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1384990 CC(C)c1cnc(cc1Sc1cnc(N)nc1N)C#C InChI=1S/C14H15N5S/c1-4-9-5-11(10(6-17-9)8(2)3)20-12-7-18-14(16)19-13(12)15/h1,5-8H,2-3H3,(H4,15,16,18,19) PVOUUQULJNSJOF-UHFFFAOYSA-N 656905 5-((2-ethynyl- 5-isopropyl- pyrdin-4- yl)thio) pyrimidine- 2,4-diamine::US11919918, Compound C88 P2X purinoceptor 3 Homo sapiens 133 US Patent 10.7270/Q24F1W1X US11919918 Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F BEIJING TIDE PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656905 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656905&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 148980196 496175971 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1384991 CSc1cc(Sc2cnc(N)nc2N)c(cn1)C(C)C InChI=1S/C13H17N5S2/c1-7(2)8-5-16-11(19-3)4-9(8)20-10-6-17-13(15)18-12(10)14/h4-7H,1-3H3,(H4,14,15,17,18) BWFZYZCFPMPZSF-UHFFFAOYSA-N 656906 5-((5- isopropyl2- (methylthio) pyridin-4- yl)thio) pyrimidine- 2,4-diamine::US11919918, Compound C91 P2X purinoceptor 3 Homo sapiens 227 US Patent 10.7270/Q24F1W1X US11919918 Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F BEIJING TIDE PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656906 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656906&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 147163199 496175972 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1384992 CC(C)c1cnc(C)cc1Sc1cnc(N)nc1N InChI=1S/C13H17N5S/c1-7(2)9-5-16-8(3)4-10(9)19-11-6-17-13(15)18-12(11)14/h4-7H,1-3H3,(H4,14,15,17,18) JOHQHBOLGWWBLV-UHFFFAOYSA-N 656907 5-((5- isopropyl-2- methylpyridin- 4-yl)thio) pyrimidine-2,4- diamine::US11919918, Compound C92 P2X purinoceptor 3 Homo sapiens 109 US Patent 10.7270/Q24F1W1X US11919918 Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F BEIJING TIDE PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656907 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656907&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155124180 496175973 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1384993 CC(C)c1cnc(C=C)cc1Sc1cnc(N)nc1N InChI=1S/C14H17N5S/c1-4-9-5-11(10(6-17-9)8(2)3)20-12-7-18-14(16)19-13(12)15/h4-8H,1H2,2-3H3,(H4,15,16,18,19) CDEYQQUBKOBYOR-UHFFFAOYSA-N 656908 US11919918, Compound C95 P2X purinoceptor 3 Homo sapiens 138 US Patent 10.7270/Q24F1W1X US11919918 Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F BEIJING TIDE PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656908 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656908&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 142576068 496175974 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1384994 CC(C)c1cnc(Br)cc1Oc1cnc(NC(CO)CO)nc1N InChI=1S/C15H20BrN5O3/c1-8(2)10-4-18-13(16)3-11(10)24-12-5-19-15(21-14(12)17)20-9(6-22)7-23/h3-5,8-9,22-23H,6-7H2,1-2H3,(H3,17,19,20,21) OSHJDJRUKMFRDG-UHFFFAOYSA-N 656909 2-((4-amino-5- ((2-bromo-5- isopropyl- pyridin-4- yl)oxy) pyrimidin-2- yl)amino) propane-1,3-diol::US11919918, Compound C111 P2X purinoceptor 3 Homo sapiens 104 US Patent 10.7270/Q24F1W1X US11919918 Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F BEIJING TIDE PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656909 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656909&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 148823744 496175975 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1384995 CCSc1cc(Oc2cnc(N)nc2N)c(cn1)C(C)C InChI=1S/C14H19N5OS/c1-4-21-12-5-10(9(6-17-12)8(2)3)20-11-7-18-14(16)19-13(11)15/h5-8H,4H2,1-3H3,(H4,15,16,18,19) AKEDQYHLXJPQLZ-UHFFFAOYSA-N 656910 5-((2- (ethylthio)-5- isopropylpyridin- 4-yl)oxy) pyrimidine- 2,4-diamine::US11919918, Compound C117 P2X purinoceptor 3 Homo sapiens 151 US Patent 10.7270/Q24F1W1X US11919918 Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F BEIJING TIDE PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656910 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656910&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155124176 496175976 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1384996 CCNc1cc(Oc2cnc(N)nc2N)c(cn1)C(C)C InChI=1S/C14H20N6O/c1-4-17-12-5-10(9(6-18-12)8(2)3)21-11-7-19-14(16)20-13(11)15/h5-8H,4H2,1-3H3,(H,17,18)(H4,15,16,19,20) CRJCWJFKFRPLTC-UHFFFAOYSA-N 656911 5-((2- (ethylamino)- 5-isopropylpyridin- 4-yl)oxy) pyrimidine- 2,4-diamine::US11919918, Compound C118 P2X purinoceptor 3 Homo sapiens 142 US Patent 10.7270/Q24F1W1X US11919918 Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F BEIJING TIDE PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656911 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656911&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155124110 496175977 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1384997 CC(C)c1cnc(NC2CC2)cc1Oc1cnc(N)nc1N InChI=1S/C15H20N6O/c1-8(2)10-6-18-13(20-9-3-4-9)5-11(10)22-12-7-19-15(17)21-14(12)16/h5-9H,3-4H2,1-2H3,(H,18,20)(H4,16,17,19,21) BOKPYXYHQNMPNH-UHFFFAOYSA-N 656912 5-((2- (cyclopropylamino)- 5-isopropylpyridin- 4-yl)oxy)pyrimidine- 2,4-diamine::US11919918, Compound C119 P2X purinoceptor 3 Homo sapiens 540 US Patent 10.7270/Q24F1W1X US11919918 Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F BEIJING TIDE PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656912 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656912&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 149807136 496175978 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1384998 CC(C)Nc1cc(Oc2cnc(N)nc2N)c(cn1)C(C)C InChI=1S/C15H22N6O/c1-8(2)10-6-18-13(20-9(3)4)5-11(10)22-12-7-19-15(17)21-14(12)16/h5-9H,1-4H3,(H,18,20)(H4,16,17,19,21) WTPMMYJWOWZVGX-UHFFFAOYSA-N 656913 5-((5- isopropyl-2- (isopropylamino) pyridin-4- yl)oxy)pyrimidine- 2,4-diamine::US11919918, Compound C120 P2X purinoceptor 3 Homo sapiens 492 US Patent 10.7270/Q24F1W1X US11919918 Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F BEIJING TIDE PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656913 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656913&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 152322015 496175979 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1384999 COc1cc(Oc2cnc(N)nc2N)c(Br)cn1 InChI=1S/C10H10BrN5O2/c1-17-8-2-6(5(11)3-14-8)18-7-4-15-10(13)16-9(7)12/h2-4H,1H3,(H4,12,13,15,16) BRBPLBPEOHAFDU-UHFFFAOYSA-N 656914 US11919918, Compound C124 P2X purinoceptor 3 Homo sapiens 1243 US Patent 10.7270/Q24F1W1X US11919918 Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F BEIJING TIDE PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656914 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656914&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 142576036 496175980 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1385000 CCSc1cc(Sc2cnc(N)nc2N)c(cn1)C(C)C InChI=1S/C14H19N5S2/c1-4-20-12-5-10(9(6-17-12)8(2)3)21-11-7-18-14(16)19-13(11)15/h5-8H,4H2,1-3H3,(H4,15,16,18,19) BLCCPYCKCLQQOP-UHFFFAOYSA-N 656915 5-((2- (ethylthio)-5- isopropyl- pyridin-4- yl)thio) pyrimidine- 2,4-diamine::US11919918, Compound C125 P2X purinoceptor 3 Homo sapiens 731 US Patent 10.7270/Q24F1W1X US11919918 Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F BEIJING TIDE PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656915 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656915&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155124147 496175981 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1385001 CCc1cc(Sc2cnc(N)nc2N)c(cn1)C(C)C InChI=1S/C14H19N5S/c1-4-9-5-11(10(6-17-9)8(2)3)20-12-7-18-14(16)19-13(12)15/h5-8H,4H2,1-3H3,(H4,15,16,18,19) NOONYIJXAZILAG-UHFFFAOYSA-N 656916 US11919918, Compound C127 P2X purinoceptor 3 Homo sapiens 147 US Patent 10.7270/Q24F1W1X US11919918 Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F BEIJING TIDE PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656916 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656916&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 142576039 496175982 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1385002 CC(C)c1cnc(cc1Oc1cnc(N)nc1N)C(N)=O InChI=1S/C13H16N6O2/c1-6(2)7-4-17-8(12(15)20)3-9(7)21-10-5-18-13(16)19-11(10)14/h3-6H,1-2H3,(H2,15,20)(H4,14,16,18,19) TVTUMNPSLBNZGX-UHFFFAOYSA-N 656917 4-((2,4- diamino- pyrimidin- 5-yl)oxy)-5- isopropyl- picolinamide::US11919918, Compound C129 P2X purinoceptor 3 Homo sapiens 377 US Patent 10.7270/Q24F1W1X US11919918 Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F BEIJING TIDE PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656917 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656917&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155124118 496175983 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1385003 CC(C)c1cnc(cc1Sc1cnc(N)nc1N)[Si](C)(C)C InChI=1S/C15H23N5SSi/c1-9(2)10-7-18-13(22(3,4)5)6-11(10)21-12-8-19-15(17)20-14(12)16/h6-9H,1-5H3,(H4,16,17,19,20) FFASROZGQOVOOX-UHFFFAOYSA-N 656918 US11919918, Compound C133 P2X purinoceptor 3 Homo sapiens 1441 US Patent 10.7270/Q24F1W1X US11919918 Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F BEIJING TIDE PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656918 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656918&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 171392712 496175984 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1385004 CC#Cc1cc(Oc2cnc(N)nc2N)c(cn1)C(C)C InChI=1S/C15H17N5O/c1-4-5-10-6-12(11(7-18-10)9(2)3)21-13-8-19-15(17)20-14(13)16/h6-9H,1-3H3,(H4,16,17,19,20) FICXDGOQGVTZHX-UHFFFAOYSA-N 656919 5-((5- isopropyl-2- (prop-1-yn-1- yl)pyridin-4- yl)oxy) pyrimidine-2,4- diamine::US11919918, Compound C134 P2X purinoceptor 3 Homo sapiens 391 US Patent 10.7270/Q24F1W1X US11919918 Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F BEIJING TIDE PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656919 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656919&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 147504835 496175985 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1385005 CC(C)c1cnc(cc1Oc1cnc(N)nc1N)C#Cc1ccccc1 InChI=1S/C20H19N5O/c1-13(2)16-11-23-15(9-8-14-6-4-3-5-7-14)10-17(16)26-18-12-24-20(22)25-19(18)21/h3-7,10-13H,1-2H3,(H4,21,22,24,25) FYANIFPIHNQHSL-UHFFFAOYSA-N 656920 5-((5- isopropyl-2- (phenyl- ethynyl)pyridin- 4-yl)oxy) pyrimidine-2,4- diamine::US11919918, Compound C135 P2X purinoceptor 3 Homo sapiens 303 US Patent 10.7270/Q24F1W1X US11919918 Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F BEIJING TIDE PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656920 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656920&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 147589652 496175986 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1385006 COc1ccc(cc1)C#Cc1cc(Oc2cnc(N)nc2N)c(cn1)C(C)C InChI=1S/C21H21N5O2/c1-13(2)17-11-24-15(7-4-14-5-8-16(27-3)9-6-14)10-18(17)28-19-12-25-21(23)26-20(19)22/h5-6,8-13H,1-3H3,(H4,22,23,25,26) LFTNEZMAGHDYFJ-UHFFFAOYSA-N 656921 5-((5- isopropyl-2- ((4- methoxyphenyl) ethynyl)pyridin- 4-yl)oxy) pyrimidine- 2,4-diamine::US11919918, Compound C136 P2X purinoceptor 3 Homo sapiens 270 US Patent 10.7270/Q24F1W1X US11919918 Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F BEIJING TIDE PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656921 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656921&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 150929702 496175987 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1385007 CC(C)c1cnc(cc1Oc1cnc(N)nc1N)C#Cc1ccc(cc1)C#N InChI=1S/C21H18N6O/c1-13(2)17-11-25-16(8-7-14-3-5-15(10-22)6-4-14)9-18(17)28-19-12-26-21(24)27-20(19)23/h3-6,9,11-13H,1-2H3,(H4,23,24,26,27) HKUNGVHAVIJXRM-UHFFFAOYSA-N 656922 4-((4-(2,4- diaminopyrimidin- 5-yl)oxy)-5- isopropylpyridin- 2-yl)ethynyl) benzonitrile::US11919918, Compound C137 P2X purinoceptor 3 Homo sapiens 503 US Patent 10.7270/Q24F1W1X US11919918 Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F BEIJING TIDE PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656922 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656922&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155124107 496175988 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1385008 CC(C)c1cnc(\C=C\c2ccccc2)cc1Oc1cnc(N)nc1N InChI=1S/C20H21N5O/c1-13(2)16-11-23-15(9-8-14-6-4-3-5-7-14)10-17(16)26-18-12-24-20(22)25-19(18)21/h3-13H,1-2H3,(H4,21,22,24,25)/b9-8+ RLUHVAVFSKWBNW-CMDGGOBGSA-N 656923 (E)-5-((5- isopropyl-2- styrylpyridin-4- yl)oxy) pyrimidine- 2,4-diamine::US11919918, Compound C138 P2X purinoceptor 3 Homo sapiens 635 US Patent 10.7270/Q24F1W1X US11919918 Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F BEIJING TIDE PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656923 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656923&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155130605 496175989 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1385009 CC(C)c1cnc(cc1Oc1cnc(N)nc1N)C#CC1CC1 InChI=1S/C17H19N5O/c1-10(2)13-8-20-12(6-5-11-3-4-11)7-14(13)23-15-9-21-17(19)22-16(15)18/h7-11H,3-4H2,1-2H3,(H4,18,19,21,22) PVHVQMXMWCXFNA-UHFFFAOYSA-N 656924 5-((2- (cyclo- propylethynyl)-5- isopropylpyrdin- 4-yl)oxy) pyrimidine-2,4- diamine::US11919918, Compound C142 P2X purinoceptor 3 Homo sapiens 302 US Patent 10.7270/Q24F1W1X US11919918 Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F BEIJING TIDE PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656924 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656924&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 148978754 496175990 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1385010 COc1cc(OC)c(C#Cc2cc(Oc3cnc(N)nc3N)c(cn2)C(C)C)c(OC)c1 InChI=1S/C23H25N5O4/c1-13(2)17-11-26-14(8-20(17)32-21-12-27-23(25)28-22(21)24)6-7-16-18(30-4)9-15(29-3)10-19(16)31-5/h8-13H,1-5H3,(H4,24,25,27,28) VJMUDXGGLHQMCM-UHFFFAOYSA-N 656925 5-((5-isopropyl-2- ((2,4,6- trimethoxyphenyl) ethynyl)pyridin-4- yl)oxy)pyrimidine- 2,4-diamine::US11919918, Compound C145 P2X purinoceptor 3 Homo sapiens 809 US Patent 10.7270/Q24F1W1X US11919918 Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F BEIJING TIDE PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656925 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656925&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 152142460 496175991 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1385011 CC(C)c1cnc(cc1Oc1cnc(N)nc1N)C#Cc1ccc(cc1)N(C)C InChI=1S/C22H24N6O/c1-14(2)18-12-25-16(8-5-15-6-9-17(10-7-15)28(3)4)11-19(18)29-20-13-26-22(24)27-21(20)23/h6-7,9-14H,1-4H3,(H4,23,24,26,27) DKTDGMNQZZWPGF-UHFFFAOYSA-N 656926 5-((2-((4- (dimethylamino) phenyl) ethynyl)-5- isopropylpyridin- 4-yl)oxy) pyrimidine-2,4- diamine::US11919918, Compound C148 P2X purinoceptor 3 Homo sapiens 215 US Patent 10.7270/Q24F1W1X US11919918 Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F BEIJING TIDE PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656926 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656926&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 150048271 496175992 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1385012 CC(C)c1cnc(cc1Oc1cnc(N)nc1N)C#Cc1cccc2cccnc12 InChI=1S/C23H20N6O/c1-14(2)18-12-27-17(11-19(18)30-20-13-28-23(25)29-22(20)24)9-8-16-6-3-5-15-7-4-10-26-21(15)16/h3-7,10-14H,1-2H3,(H4,24,25,28,29) GHVNDPJDWUQRFN-UHFFFAOYSA-N 656927 5-((5-isopropyl-2- (quinolin-8- ylethynyl)pyridin- 4- yl)oxy)pyrimidine- 2,4-diamine::US11919918, Compound C149 P2X purinoceptor 3 Homo sapiens 130 US Patent 10.7270/Q24F1W1X US11919918 Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F BEIJING TIDE PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656927 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656927&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155124114 496175993 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1385013 CC(C)c1cnc(cc1Oc1cnc(N)nc1N)C#Cc1ccccn1 InChI=1S/C19H18N6O/c1-12(2)15-10-23-14(7-6-13-5-3-4-8-22-13)9-16(15)26-17-11-24-19(21)25-18(17)20/h3-5,8-12H,1-2H3,(H4,20,21,24,25) QBWVEPYAYJVLEC-UHFFFAOYSA-N 656928 5-((5-isopropyl-2- (pyridin-2- ylethynyl)pyridin- 4- yl)oxy)pyrimidine- 2,4-diamine::US11919918, Compound C150 P2X purinoceptor 3 Homo sapiens 211 US Patent 10.7270/Q24F1W1X US11919918 Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F BEIJING TIDE PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656928 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656928&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 151558019 496175994 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1385014 CC(C)c1cnc(cc1Oc1cnc(N)nc1N)C#Cc1ccncc1 InChI=1S/C19H18N6O/c1-12(2)15-10-23-14(4-3-13-5-7-22-8-6-13)9-16(15)26-17-11-24-19(21)25-18(17)20/h5-12H,1-2H3,(H4,20,21,24,25) VLXHZXIGOVJXCC-UHFFFAOYSA-N 656929 5-((5-isopropyl-2- (pyridin-4- ylethynyl)pyridin- 4- yl)oxy)pyrimidine- 2,4-diamine::US11919918, Compound C151 P2X purinoceptor 3 Homo sapiens 590 US Patent 10.7270/Q24F1W1X US11919918 Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F BEIJING TIDE PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656929 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656929&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155124168 496175995 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1385015 CC(C)c1cnc(NCC(F)(F)F)cc1Oc1cnc(N)nc1N InChI=1S/C14H17F3N6O/c1-7(2)8-4-20-11(22-6-14(15,16)17)3-9(8)24-10-5-21-13(19)23-12(10)18/h3-5,7H,6H2,1-2H3,(H,20,22)(H4,18,19,21,23) BYBDRISYVLDBFK-UHFFFAOYSA-N 656930 5-((5- isopropyl-2- (2,2,2- trifluoroethyl) amino) pyridin-4- yl)oxy) pyrimidine- 2,4-diamine::US11919918, Compound C152 P2X purinoceptor 3 Homo sapiens 211 US Patent 10.7270/Q24F1W1X US11919918 Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F BEIJING TIDE PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656930 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656930&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 147172849 496175996 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1385016 CC(C)c1cnc(Br)cc1Oc1cnc(N)nc1NC(CO)CO InChI=1S/C15H20BrN5O3/c1-8(2)10-4-18-13(16)3-11(10)24-12-5-19-15(17)21-14(12)20-9(6-22)7-23/h3-5,8-9,22-23H,6-7H2,1-2H3,(H3,17,19,20,21) JQZGMYVGSHHBDG-UHFFFAOYSA-N 656931 2-((2-amino-5- ((2-bromo-5- isopropylpyridin- 4-yl)oxy) pyrimidin-4- yl)amino) propane-1,3-diol::US11919918, Compound C153 P2X purinoceptor 3 Homo sapiens 83.0 US Patent 10.7270/Q24F1W1X US11919918 Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F BEIJING TIDE PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656931 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656931&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 148109302 496175997 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1385017 CCN(C)CCNc1nc(N)ncc1Oc1cc(Br)ncc1C(C)C InChI=1S/C17H25BrN6O/c1-5-24(4)7-6-20-16-14(10-22-17(19)23-16)25-13-8-15(18)21-9-12(13)11(2)3/h8-11H,5-7H2,1-4H3,(H3,19,20,22,23) UFAGZDFWUPYOKN-UHFFFAOYSA-N 656932 US11919918, Compound C154 P2X purinoceptor 3 Homo sapiens 72.0 US Patent 10.7270/Q24F1W1X US11919918 Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F BEIJING TIDE PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656932 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656932&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 151992747 496175998 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1385018 CC(C)c1cnc(CC(=O)c2ccc(cc2)N(C)C)cc1Oc1cnc(N)nc1N InChI=1S/C22H26N6O2/c1-13(2)17-11-25-15(9-18(29)14-5-7-16(8-6-14)28(3)4)10-19(17)30-20-12-26-22(24)27-21(20)23/h5-8,10-13H,9H2,1-4H3,(H4,23,24,26,27) HVVAPUVQUBUOMY-UHFFFAOYSA-N 656933 2-(4-(2,4- diamino- pyrimidin- 5-yl)oxy)-5- isopropylpyridin- 2-yl)-1-(4- (dimethylamino) phenyl)ethanone::US11919918, Compound C155 P2X purinoceptor 3 Homo sapiens 926 US Patent 10.7270/Q24F1W1X US11919918 Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F BEIJING TIDE PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656933 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656933&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 147856398 496175999 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1385019 CC(C)c1cnc(CN)cc1Oc1cnc(N)nc1N InChI=1S/C13H18N6O/c1-7(2)9-5-17-8(4-14)3-10(9)20-11-6-18-13(16)19-12(11)15/h3,5-7H,4,14H2,1-2H3,(H4,15,16,18,19) KHKXFAJFCUEAGK-UHFFFAOYSA-N 656934 US11919918, Compound C157 P2X purinoceptor 3 Homo sapiens 736 US Patent 10.7270/Q24F1W1X US11919918 Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F BEIJING TIDE PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656934 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656934&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 142576029 496176000 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1385020 COc1cc(Oc2cnc(N)nc2N)c(C=C)cn1 InChI=1S/C12H13N5O2/c1-3-7-5-15-10(18-2)4-8(7)19-9-6-16-12(14)17-11(9)13/h3-6H,1H2,2H3,(H4,13,14,16,17) KQZCOEOLDXOUFC-UHFFFAOYSA-N 656935 5-((2-methoxy- 5-vinylpyridin- 4-yl)oxy) pyrimidine- 2,4-diamine::US11919918, Compound C162 P2X purinoceptor 3 Homo sapiens 296 US Patent 10.7270/Q24F1W1X US11919918 Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F BEIJING TIDE PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656935 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656935&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 148257471 496176001 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1385021 COc1cc(Oc2cnc(N)nc2N)c(cn1)C(C)=C InChI=1S/C13H15N5O2/c1-7(2)8-5-16-11(19-3)4-9(8)20-10-6-17-13(15)18-12(10)14/h4-6H,1H2,2-3H3,(H4,14,15,17,18) TYZMBZZLUNQFAR-UHFFFAOYSA-N 656936 5-((2-methoxy- 5-(prop-1-en-2- yl)pyridin-4- yl)oxy) pyrimidine- 2,4-diamine::US11919918, Compound C164::US11919918, Compound C196 P2X purinoceptor 3 Homo sapiens 46.0 US Patent 10.7270/Q24F1W1X US11919918 Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F BEIJING TIDE PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656936 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656936&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 152868778 496176002 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1385022 CCc1cnc(OC)cc1Oc1cnc(N)nc1N InChI=1S/C12H15N5O2/c1-3-7-5-15-10(18-2)4-8(7)19-9-6-16-12(14)17-11(9)13/h4-6H,3H2,1-2H3,(H4,13,14,16,17) PFELYIBYHFKCBW-UHFFFAOYSA-N 656937 5-((5-ethyl-2- methoxy- pyridin-4- yl)oxy) pyrimidine- 2,4-diamine::US11919918, Compound C165 P2X purinoceptor 3 Homo sapiens 163 US Patent 10.7270/Q24F1W1X US11919918 Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F BEIJING TIDE PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656937 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656937&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 148892353 496176003 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1385023 CNc1nc(N)ncc1Oc1cc(Br)ncc1C(C)C InChI=1S/C13H16BrN5O/c1-7(2)8-5-17-11(14)4-9(8)20-10-6-18-13(15)19-12(10)16-3/h4-7H,1-3H3,(H3,15,16,18,19) NSUKKTYUFVSNHM-UHFFFAOYSA-N 656938 5-((2-bromo-5- isopropylpyridin- 4-yl)oxy)-N4- methyl- pyrimidine- 2,4-diamine::US11919918, Compound C172 P2X purinoceptor 3 Homo sapiens 116 US Patent 10.7270/Q24F1W1X US11919918 Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F BEIJING TIDE PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656938 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656938&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 148687494 496176004 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1385024 CCNc1nc(N)ncc1Oc1cc(Br)ncc1C(C)C InChI=1S/C14H18BrN5O/c1-4-17-13-11(7-19-14(16)20-13)21-10-5-12(15)18-6-9(10)8(2)3/h5-8H,4H2,1-3H3,(H3,16,17,19,20) NPEHEUZJNYCFCU-UHFFFAOYSA-N 656939 5-((2-bromo-5- isopropylpyridin- 4-yl)oxy)-N4- ethylpyrimidine- 2,4-diamine::US11919918, Compound C173 P2X purinoceptor 3 Homo sapiens 188 US Patent 10.7270/Q24F1W1X US11919918 Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F BEIJING TIDE PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656939 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656939&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 148668224 496176005 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1385025 CC(C)Nc1nc(N)ncc1Oc1cc(Br)ncc1C(C)C InChI=1S/C15H20BrN5O/c1-8(2)10-6-18-13(16)5-11(10)22-12-7-19-15(17)21-14(12)20-9(3)4/h5-9H,1-4H3,(H3,17,19,20,21) SKQJDJRXLHWOEY-UHFFFAOYSA-N 656940 5-((2-bromo-5- isopropylpyridin- 4-yl)oxy)-N4- isopropyl- pyrimidine- 2,4-diamine::US11919918, Compound C174 P2X purinoceptor 3 Homo sapiens 100.0 US Patent 10.7270/Q24F1W1X US11919918 Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F BEIJING TIDE PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656940 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656940&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 146860970 496176006 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1385026 CC(C)c1cnc(Br)cc1Oc1cnc(N)nc1NCCO InChI=1S/C14H18BrN5O2/c1-8(2)9-6-18-12(15)5-10(9)22-11-7-19-14(16)20-13(11)17-3-4-21/h5-8,21H,3-4H2,1-2H3,(H3,16,17,19,20) JZVHWPXVFWORNA-UHFFFAOYSA-N 656941 2-((2-amino-5- ((2-bromo-5- isopropylpyridin- 4-yl)oxy) pyrimidin-4- yl)amino)ethanol.::US11919918, Compound C175 P2X purinoceptor 3 Homo sapiens 108 US Patent 10.7270/Q24F1W1X US11919918 Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F BEIJING TIDE PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656941 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656941&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 148156534 496176007 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1385027 COc1cc(Oc2cnc(N)nc2N)c(C)cn1 InChI=1S/C11H13N5O2/c1-6-4-14-9(17-2)3-7(6)18-8-5-15-11(13)16-10(8)12/h3-5H,1-2H3,(H4,12,13,15,16) ZJGLBNQRURZPSI-UHFFFAOYSA-N 656942 5-((2-methoxy- 5-methylpyridin- 4-yl)oxy) pyrimidine- 2,4-diamine::US11919918, Compound C176 P2X purinoceptor 3 Homo sapiens 611 US Patent 10.7270/Q24F1W1X US11919918 Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F BEIJING TIDE PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656942 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656942&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 149513268 496176008 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1385028 CC(C)c1cnc(Br)cc1Oc1cnc(N)nc1NC1CC1 InChI=1S/C15H18BrN5O/c1-8(2)10-6-18-13(16)5-11(10)22-12-7-19-15(17)21-14(12)20-9-3-4-9/h5-9H,3-4H2,1-2H3,(H3,17,19,20,21) GZPLJULLZGHQLS-UHFFFAOYSA-N 656943 5-((2-bromo-5- isopropylpyridin- 4-yl)oxy)-N4- cyclopropyl- pyrimidine-2,4- diamine::US11919918, Compound C179 P2X purinoceptor 3 Homo sapiens 51.0 US Patent 10.7270/Q24F1W1X US11919918 Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F BEIJING TIDE PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656943 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656943&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 147737213 496176009 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1385029 CC(C)c1cnc(Br)cc1Oc1cnc(N)nc1NC1CCCCC1 InChI=1S/C18H24BrN5O/c1-11(2)13-9-21-16(19)8-14(13)25-15-10-22-18(20)24-17(15)23-12-6-4-3-5-7-12/h8-12H,3-7H2,1-2H3,(H3,20,22,23,24) GZUOIWVCCGUPHS-UHFFFAOYSA-N 656944 5-((2-bromo-5- isopropylpyridin- 4-yl)oxy)-N4- cyclohexyl- pyrimidine-2,4- diamine::US11919918, Compound C180 P2X purinoceptor 3 Homo sapiens 207 US Patent 10.7270/Q24F1W1X US11919918 Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F BEIJING TIDE PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656944 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656944&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 150381337 496176010 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1385030 CC(C)CNc1nc(N)ncc1Oc1cc(Br)ncc1C(C)C InChI=1S/C16H22BrN5O/c1-9(2)6-20-15-13(8-21-16(18)22-15)23-12-5-14(17)19-7-11(12)10(3)4/h5,7-10H,6H2,1-4H3,(H3,18,20,21,22) NFGRNNZHAVSBEF-UHFFFAOYSA-N 656945 5-((2-bromo-5- isopropylpyridin- 4-yl)oxy)-N4- isobutyl- pyrimidine- 2,4-diamine::US11919918, Compound C181 P2X purinoceptor 3 Homo sapiens 84.0 US Patent 10.7270/Q24F1W1X US11919918 Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F BEIJING TIDE PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656945 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656945&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155130483 496176011 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1385031 CC(C)c1cnc(Br)cc1Oc1cnc(N)nc1N[C@H](C)C1CC1 InChI=1S/C17H22BrN5O/c1-9(2)12-7-20-15(18)6-13(12)24-14-8-21-17(19)23-16(14)22-10(3)11-4-5-11/h6-11H,4-5H2,1-3H3,(H3,19,21,22,23)/t10-/m1/s1 CLWJJEYUHOBYLF-SNVBAGLBSA-N 656946 (R)-5-((2-bromo- 5-isopropyl pyridin-4-yl)oxy)- N4-(1-cyclopro- pylethyl) pyrimidine-2,4- diamine::US11919918, Compound C182 P2X purinoceptor 3 Homo sapiens 670 US Patent 10.7270/Q24F1W1X US11919918 Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F BEIJING TIDE PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656946 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656946&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155124164 496176012 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1385032 CNc1cc(Oc2cnc(N)nc2N)c(cn1)C(C)=C InChI=1S/C13H16N6O/c1-7(2)8-5-17-11(16-3)4-9(8)20-10-6-18-13(15)19-12(10)14/h4-6H,1H2,2-3H3,(H,16,17)(H4,14,15,18,19) BMXZCGUHPQBDFN-UHFFFAOYSA-N 656947 5-((2- (methylamino)-5- (prop-1-en-2- yl)pyridin-4- yl)oxy)pyrimidine- 2,4-diamine::US11919918, Compound C192 P2X purinoceptor 3 Homo sapiens 53.0 US Patent 10.7270/Q24F1W1X US11919918 Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F BEIJING TIDE PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656947 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656947&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155124093 496176013 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1385033 CC(C)CNc1nc(N)ncc1Oc1cc(ncc1C(C)C)C1CC1 InChI=1S/C19H27N5O/c1-11(2)8-22-18-17(10-23-19(20)24-18)25-16-7-15(13-5-6-13)21-9-14(16)12(3)4/h7,9-13H,5-6,8H2,1-4H3,(H3,20,22,23,24) UCVCWQOREWFCBG-UHFFFAOYSA-N 656948 5-((2- cyclopropyl-5- isopropyl- pyridin-4- yl)oxy)-N4- isobutyl- pyrimidine- 2,4-diamine::US11919918, Compound C194 P2X purinoceptor 3 Homo sapiens 322 US Patent 10.7270/Q24F1W1X US11919918 Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F BEIJING TIDE PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656948 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656948&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155124095 496176014 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1385034 CC(C)c1cnc(cc1Oc1cnc(N)nc1N)C#Cc1cnc2cccnn12 InChI=1S/C20H18N8O/c1-12(2)15-10-23-13(5-6-14-9-24-18-4-3-7-26-28(14)18)8-16(15)29-17-11-25-20(22)27-19(17)21/h3-4,7-12H,1-2H3,(H4,21,22,25,27) PXLKTBSMDOSNOG-UHFFFAOYSA-N 656949 5-((2- (imidazo[1,2- b]pyridazin-3- ylethynyl)-5- isopropylpyridin- 4- yl)oxy)pyrimidine- 2,4-diamine::US11919918, Compound C195 P2X purinoceptor 3 Homo sapiens 316 US Patent 10.7270/Q24F1W1X US11919918 Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F BEIJING TIDE PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656949 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656949&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155124111 496176015 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1385035 COc1cc(Oc2cnc(N)nc2N)c(cn1)C(C)=C InChI=1S/C13H15N5O2/c1-7(2)8-5-16-11(19-3)4-9(8)20-10-6-17-13(15)18-12(10)14/h4-6H,1H2,2-3H3,(H4,14,15,17,18) TYZMBZZLUNQFAR-UHFFFAOYSA-N 656936 5-((2-methoxy- 5-(prop-1-en-2- yl)pyridin-4- yl)oxy) pyrimidine- 2,4-diamine::US11919918, Compound C164::US11919918, Compound C196 P2X purinoceptor 3 Homo sapiens 208 US Patent 10.7270/Q24F1W1X US11919918 Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F BEIJING TIDE PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656936 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656936&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 152868778 496176002 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1385036 CC(C)c1cnc(Br)cc1Oc1cnc(N)nc1NCCN InChI=1S/C14H19BrN6O/c1-8(2)9-6-19-12(15)5-10(9)22-11-7-20-14(17)21-13(11)18-4-3-16/h5-8H,3-4,16H2,1-2H3,(H3,17,18,20,21) PYSAICXNVDVULB-UHFFFAOYSA-N 656951 US11919918, Compound C199 P2X purinoceptor 3 Homo sapiens 186 US Patent 10.7270/Q24F1W1X US11919918 Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F BEIJING TIDE PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656951 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656951&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 154697535 496176016 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1385037 CC(C)c1cnc(Br)cc1Oc1cnc(N)nc1NCCOCCO InChI=1S/C16H22BrN5O3/c1-10(2)11-8-20-14(17)7-12(11)25-13-9-21-16(18)22-15(13)19-3-5-24-6-4-23/h7-10,23H,3-6H2,1-2H3,(H3,18,19,21,22) FAZQNWYADVZXAG-UHFFFAOYSA-N 656952 2-(2-((2-amino- 5-((2-bromo-5- isopropylpyridin- 4-yl)oxy) pyrimidin-4- yl)amino)ethoxy) ethanol::US11919918, Compound C201 P2X purinoceptor 3 Homo sapiens 316 US Patent 10.7270/Q24F1W1X US11919918 Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F BEIJING TIDE PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656952 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656952&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155130574 496176017 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1385038 CNCCNc1nc(N)ncc1Oc1cc(Br)ncc1C(C)C InChI=1S/C15H21BrN6O/c1-9(2)10-7-20-13(16)6-11(10)23-12-8-21-15(17)22-14(12)19-5-4-18-3/h6-9,18H,4-5H2,1-3H3,(H3,17,19,21,22) IAWWKXZDWKSOBR-UHFFFAOYSA-N 656953 5-((2-bromo-5- isopropylpyridin- 4-yl)oxy)-N4-(2- (methylamino) ethyl)pyrimidine- 2,4-diamine::US11919918, Compound C202 P2X purinoceptor 3 Homo sapiens 103 US Patent 10.7270/Q24F1W1X US11919918 Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F BEIJING TIDE PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656953 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656953&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 147883534 496176018 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1385039 CC(C)c1cnc(Br)cc1Oc1cnc(N)nc1NCCN1CCOCC1 InChI=1S/C18H25BrN6O2/c1-12(2)13-10-22-16(19)9-14(13)27-15-11-23-18(20)24-17(15)21-3-4-25-5-7-26-8-6-25/h9-12H,3-8H2,1-2H3,(H3,20,21,23,24) FGTBVSNRMXRNGF-UHFFFAOYSA-N 656954 5-((2-bromo-5- isopropylpyridin- 4-yl)oxy)-N4-(2- morpholinoethyl) pyrimidine-2,4- diamine::US11919918, Compound C203 P2X purinoceptor 3 Homo sapiens 157 US Patent 10.7270/Q24F1W1X US11919918 Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F BEIJING TIDE PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656954 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656954&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 150158499 496176019 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1385040 CC(C)c1cnc(Br)cc1Oc1cnc(N)nc1NCC(O)CO InChI=1S/C15H20BrN5O3/c1-8(2)10-5-18-13(16)3-11(10)24-12-6-20-15(17)21-14(12)19-4-9(23)7-22/h3,5-6,8-9,22-23H,4,7H2,1-2H3,(H3,17,19,20,21) SEOCWZOADCEZCL-UHFFFAOYSA-N 656955 3-((2-amino-5- ((2-bromo-5- isopropylpyridin- 4-yl)oxy) pyrimidin-4- yl)amino)propane- 1,2-diol::US11919918, Compound C204 P2X purinoceptor 3 Homo sapiens 44.0 US Patent 10.7270/Q24F1W1X US11919918 Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F BEIJING TIDE PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656955 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656955&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155124166 496176020 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1385041 COCCNc1nc(N)ncc1Oc1cc(Br)ncc1C(C)C InChI=1S/C15H20BrN5O2/c1-9(2)10-7-19-13(16)6-11(10)23-12-8-20-15(17)21-14(12)18-4-5-22-3/h6-9H,4-5H2,1-3H3,(H3,17,18,20,21) QIRCKPWWYRZIGW-UHFFFAOYSA-N 656956 5-((2-bromo-5- isopropylpyridin- 4-yl)oxy)-N4-(2- methoxyethyl) pyrimidine-2,4- diamine::US11919918, Compound C207 P2X purinoceptor 3 Homo sapiens 113 US Patent 10.7270/Q24F1W1X US11919918 Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F BEIJING TIDE PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656956 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656956&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155124154 496176021 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1385042 CSc1cc(Oc2cnc(N)nc2N)c(cn1)C(C)=C InChI=1S/C13H15N5OS/c1-7(2)8-5-16-11(20-3)4-9(8)19-10-6-17-13(15)18-12(10)14/h4-6H,1H2,2-3H3,(H4,14,15,17,18) KCCROHRVXBGCSG-UHFFFAOYSA-N 656957 5-((2- (methylthio)-5- (prop-1-en-2- yl)pyridin-4- yl)oxy) pyrimidine- 2,4-diamine::US11919918, Compound C208 P2X purinoceptor 3 Homo sapiens 75.3 US Patent 10.7270/Q24F1W1X US11919918 Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F BEIJING TIDE PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656957 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656957&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155124153 496176022 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1385043 CC[C@@H](CO)Nc1nc(N)ncc1Oc1cc(Br)ncc1C(C)C InChI=1S/C16H22BrN5O2/c1-4-10(8-23)21-15-13(7-20-16(18)22-15)24-12-5-14(17)19-6-11(12)9(2)3/h5-7,9-10,23H,4,8H2,1-3H3,(H3,18,20,21,22)/t10-/m0/s1 LFYGPDQOVAJAJS-JTQLQIEISA-N 656958 (S)-2-((2-amino- 5-((2-bromo-5- isopropylpyridin- 4-yl)oxy) pyrimidin-4-yl) amino)but-1-ol::US11919918, Compound C209 P2X purinoceptor 3 Homo sapiens 144 US Patent 10.7270/Q24F1W1X US11919918 Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F BEIJING TIDE PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656958 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656958&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155124159 496176023 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1385044 CC(C)c1cnc(Br)cc1Oc1cnc(N)nc1NCCN1CCCC1 InChI=1S/C18H25BrN6O/c1-12(2)13-10-22-16(19)9-14(13)26-15-11-23-18(20)24-17(15)21-5-8-25-6-3-4-7-25/h9-12H,3-8H2,1-2H3,(H3,20,21,23,24) YTMXRNWUCVEAOA-UHFFFAOYSA-N 656959 5-((2-bromo-5- isopropylpyridin- 4-yl)oxy)-N4-(2- (pyrrolidin-1- yl)ethyl) pyrimidine-2,4- diamine::US11919918, Compound C210 P2X purinoceptor 3 Homo sapiens 269 US Patent 10.7270/Q24F1W1X US11919918 Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F BEIJING TIDE PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656959 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656959&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155124148 496176024 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1385045 CC(C)c1cnc(cc1Oc1cnc(N)nc1NCCO)C#C InChI=1S/C16H19N5O2/c1-4-11-7-13(12(8-19-11)10(2)3)23-14-9-20-16(17)21-15(14)18-5-6-22/h1,7-10,22H,5-6H2,2-3H3,(H3,17,18,20,21) YHDIEVLGUSQXQC-UHFFFAOYSA-N 656960 2-((2-amino-5-((2- ethynyl-5- isopropylpyridin- 4- yl)oxy)pyrimidin- 4-yl)amino)ethanol::US11919918, Compound C211 P2X purinoceptor 3 Homo sapiens 64.0 US Patent 10.7270/Q24F1W1X US11919918 Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F BEIJING TIDE PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656960 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656960&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155124163 496176025 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1385046 CC(C)Nc1nc(N)ncc1Oc1cc(ncc1C(C)C)C#C InChI=1S/C17H21N5O/c1-6-12-7-14(13(8-19-12)10(2)3)23-15-9-20-17(18)22-16(15)21-11(4)5/h1,7-11H,2-5H3,(H3,18,20,21,22) UJADEXKGQLLXLW-UHFFFAOYSA-N 656961 US11919918, Compound C212 P2X purinoceptor 3 Homo sapiens 81.0 US Patent 10.7270/Q24F1W1X US11919918 Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F BEIJING TIDE PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656961 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656961&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 154697532 496176026 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1385047 CNc1nc(N)ncc1Oc1cc(ncc1C(C)C)C#C InChI=1S/C15H17N5O/c1-5-10-6-12(11(7-18-10)9(2)3)21-13-8-19-15(16)20-14(13)17-4/h1,6-9H,2-4H3,(H3,16,17,19,20) SGFWCSOFJRTTSA-UHFFFAOYSA-N 656962 5-((2-ethynyl-5- isopropylpyridin- 4-yl)oxy)-N4- methylpyrimidine- 2,4-diamine::US11919918, Compound C213 P2X purinoceptor 3 Homo sapiens 112 US Patent 10.7270/Q24F1W1X US11919918 Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F BEIJING TIDE PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656962 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656962&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 151838871 496176027 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1385048 CCNc1cc(Oc2cnc(N)nc2NC)c(cn1)C(C)=C InChI=1S/C15H20N6O/c1-5-18-13-6-11(10(7-19-13)9(2)3)22-12-8-20-15(16)21-14(12)17-4/h6-8H,2,5H2,1,3-4H3,(H,18,19)(H3,16,17,20,21) NQHQIQIXEGBYJO-UHFFFAOYSA-N 656963 US11919918, Compound C214 P2X purinoceptor 3 Homo sapiens 44.0 US Patent 10.7270/Q24F1W1X US11919918 Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F BEIJING TIDE PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656963 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656963&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 171392713 496176028 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1385049 CC(=C)c1cnc(cc1Oc1cnc(N)nc1N)C#C InChI=1S/C14H13N5O/c1-4-9-5-11(10(6-17-9)8(2)3)20-12-7-18-14(16)19-13(12)15/h1,5-7H,2H2,3H3,(H4,15,16,18,19) OTAPLTATGFXASH-UHFFFAOYSA-N 656964 5-((2-ethynyl- 5-(prop-1-en- 2-yl)pyridin- 4-yl)oxy) pyrimidine-2,4- diamine::US11919918, Compound C215 P2X purinoceptor 3 Homo sapiens 88.2 US Patent 10.7270/Q24F1W1X US11919918 Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F BEIJING TIDE PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656964 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656964&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 148827576 496176029 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1385050 CC(C)c1cnc(cc1Oc1cnc(N)nc1NCC(O)CO)C#C InChI=1S/C17H21N5O3/c1-4-11-5-14(13(7-19-11)10(2)3)25-15-8-21-17(18)22-16(15)20-6-12(24)9-23/h1,5,7-8,10,12,23-24H,6,9H2,2-3H3,(H3,18,20,21,22) AGYFXRNEMIJQTN-UHFFFAOYSA-N 656965 3-((2-amino-5-((2- ethynyl-5- isopropylpyridin- 4- yl)oxy)pyrimidin- 4- yl)amino)propane- 1,2-diol::US11919918, Compound C216 P2X purinoceptor 3 Homo sapiens 62.0 US Patent 10.7270/Q24F1W1X US11919918 Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F BEIJING TIDE PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656965 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656965&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155124091 496176030 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1385051 CC(C)c1cnc(Cl)cc1Oc1cnc(NC(CO)CO)nc1N InChI=1S/C15H20ClN5O3/c1-8(2)10-4-18-13(16)3-11(10)24-12-5-19-15(21-14(12)17)20-9(6-22)7-23/h3-5,8-9,22-23H,6-7H2,1-2H3,(H3,17,19,20,21) XKNOJCAJUXXJRE-UHFFFAOYSA-N 656966 2-((4-amino-5- ((2-chloro-5- isopropyl- pyridin-4- yl)oxy) pyrimidin-2- yl)amino) propane-1,3-diol::US11919918, Compound C218 P2X purinoceptor 3 Homo sapiens 186 US Patent 10.7270/Q24F1W1X US11919918 Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F BEIJING TIDE PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656966 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656966&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155124158 496176031 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1385052 CC(C)c1cnc(Br)cc1Oc1cnc(N)nc1NNC(=O)OC(C)(C)C InChI=1S/C17H23BrN6O3/c1-9(2)10-7-20-13(18)6-11(10)26-12-8-21-15(19)22-14(12)23-24-16(25)27-17(3,4)5/h6-9H,1-5H3,(H,24,25)(H3,19,21,22,23) QGQVMHZDHBSHPF-UHFFFAOYSA-N 656967 US11919918, Compound C222::tert-butyl 2-(2- amino-5-((2- bromo-5- isopropylpyridin- 4-yl)oxy) pyrimidin- 4-yl)hydrazine- 1-carboxylate P2X purinoceptor 3 Homo sapiens 48.0 US Patent 10.7270/Q24F1W1X US11919918 Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F BEIJING TIDE PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656967 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656967&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155124157 496176032 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1385053 CC(C)c1cnc(Br)cc1Oc1cnc(NCCO)nc1NCCO InChI=1S/C16H22BrN5O3/c1-10(2)11-8-20-14(17)7-12(11)25-13-9-21-16(19-4-6-24)22-15(13)18-3-5-23/h7-10,23-24H,3-6H2,1-2H3,(H2,18,19,21,22) YHIOLCMCLRXKRZ-UHFFFAOYSA-N 656968 US11919918, Compound C226 P2X purinoceptor 3 Homo sapiens 115 US Patent 10.7270/Q24F1W1X US11919918 Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F BEIJING TIDE PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656968 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656968&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 152520098 496176033 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1385054 CNc1ncc(Oc2cc(Br)ncc2C(C)C)c(NC)n1 InChI=1S/C14H18BrN5O/c1-8(2)9-6-18-12(15)5-10(9)21-11-7-19-14(17-4)20-13(11)16-3/h5-8H,1-4H3,(H2,16,17,19,20) LFQMOUWGNZJGFU-UHFFFAOYSA-N 656969 5-((2-bromo-5- isopropylpyridin- 4-yl)oxy)- N2,N4- dimethylpyrimidine- 2,4-diamine::US11919918, Compound C227 P2X purinoceptor 3 Homo sapiens 948 US Patent 10.7270/Q24F1W1X US11919918 Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F BEIJING TIDE PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656969 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656969&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155124144 496176034 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1385055 CC(C)c1cnc(cc1Oc1cnc(NC(CO)CO)nc1N)C#C InChI=1S/C17H21N5O3/c1-4-11-5-14(13(6-19-11)10(2)3)25-15-7-20-17(22-16(15)18)21-12(8-23)9-24/h1,5-7,10,12,23-24H,8-9H2,2-3H3,(H3,18,20,21,22) MQZWDJDIDPZYBO-UHFFFAOYSA-N 656970 2-((4-amino- 5-((2-ethynyl- 5-isopropyl- pyrdin-4- yl)oxy) pyrimidin-2- yl)amino) propane-1,3-diol::US11919918, Compound C228 P2X purinoceptor 3 Homo sapiens 119 US Patent 10.7270/Q24F1W1X US11919918 Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F BEIJING TIDE PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656970 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656970&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 148534921 496176035 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1385056 CC(C)c1cnc(cc1Oc1cnc(NCC(O)CO)nc1N)C#C InChI=1S/C17H21N5O3/c1-4-11-5-14(13(7-19-11)10(2)3)25-15-8-21-17(22-16(15)18)20-6-12(24)9-23/h1,5,7-8,10,12,23-24H,6,9H2,2-3H3,(H3,18,20,21,22) PZTYGEXXYPKZJJ-UHFFFAOYSA-N 656971 3-((4-amino- 5-((2-ethynyl- 5-isopropyl- pyridin-4- yl)oxy) pyrimidin-2- yl)amino) propane-l,2-diol::US11919918, Compound C229 P2X purinoceptor 3 Homo sapiens 65.0 US Patent 10.7270/Q24F1W1X US11919918 Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F BEIJING TIDE PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656971 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656971&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155124160 496176036 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1385057 CC(C)c1cnc(cc1Oc1cnc(NCCO)nc1N)C#C InChI=1S/C16H19N5O2/c1-4-11-7-13(12(8-19-11)10(2)3)23-14-9-20-16(18-5-6-22)21-15(14)17/h1,7-10,22H,5-6H2,2-3H3,(H3,17,18,20,21) ZXIDAHPYCRJDPU-UHFFFAOYSA-N 656972 2-((4-amino- 5-((2-ethynyl- 5-isopropyl- pyridin-4- yl)oxy) pyrimidin-2- yl)amino) ethanol::US11919918, Compound C230 P2X purinoceptor 3 Homo sapiens 60.0 US Patent 10.7270/Q24F1W1X US11919918 Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F BEIJING TIDE PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656972 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656972&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155124149 496176037 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1385058 CC(C)Nc1ncc(Oc2cc(ncc2C(C)C)C#C)c(N)n1 InChI=1S/C17H21N5O/c1-6-12-7-14(13(8-19-12)10(2)3)23-15-9-20-17(21-11(4)5)22-16(15)18/h1,7-11H,2-5H3,(H3,18,20,21,22) QTVZTOWEFAZUSO-UHFFFAOYSA-N 656973 5-((2-ethynyl- 5-isopropyl- pyrdin-4-yl)oxy)- N2-isopropyl- pyrmidine-2,4- diamine::US11919918, Compound C233 P2X purinoceptor 3 Homo sapiens 72.0 US Patent 10.7270/Q24F1W1X US11919918 Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F BEIJING TIDE PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656973 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656973&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 149097298 496176038 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1385059 CC(C)c1cnc(Br)cc1Oc1cnc(NCC(O)CO)nc1N InChI=1S/C15H20BrN5O3/c1-8(2)10-5-18-13(16)3-11(10)24-12-6-20-15(21-14(12)17)19-4-9(23)7-22/h3,5-6,8-9,22-23H,4,7H2,1-2H3,(H3,17,19,20,21) VCUSKAIJOFOHAB-UHFFFAOYSA-N 656974 3-((4-amino-5- ((2-bromo-5- isopropyl- pyridin-4- yl)oxy) pyrimidin-2- yl)amino) propane- 1,2-diol::US11919918, Compound C235 P2X purinoceptor 3 Homo sapiens 90.0 US Patent 10.7270/Q24F1W1X US11919918 Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F BEIJING TIDE PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656974 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656974&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155124181 496176039 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1385060 CC(C)c1cnc(Br)cc1Oc1cnc(NCCO)nc1N InChI=1S/C14H18BrN5O2/c1-8(2)9-6-18-12(15)5-10(9)22-11-7-19-14(17-3-4-21)20-13(11)16/h5-8,21H,3-4H2,1-2H3,(H3,16,17,19,20) MNMSVFJDRFNAHP-UHFFFAOYSA-N 656975 2-((4-amino-5- ((2-bromo-5- isopropyl- pyridin-4- yl)oxy) pyrimidin-2- yl)amino)ethanol::US11919918, Compound C236 P2X purinoceptor 3 Homo sapiens 88.0 US Patent 10.7270/Q24F1W1X US11919918 Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F BEIJING TIDE PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656975 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656975&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155124161 496176040 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1385061 CNc1ncc(Oc2cc(Br)ncc2C(C)C)c(N)n1 InChI=1S/C13H16BrN5O/c1-7(2)8-5-17-11(14)4-9(8)20-10-6-18-13(16-3)19-12(10)15/h4-7H,1-3H3,(H3,15,16,18,19) BCYBLDAMYYNWEX-UHFFFAOYSA-N 656976 US11919918, Compound C237 P2X purinoceptor 3 Homo sapiens 363 US Patent 10.7270/Q24F1W1X US11919918 Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F BEIJING TIDE PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656976 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656976&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 149749701 496176041 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1385062 CC(C)c1cnc(Br)cc1Oc1cnc(NC2CC2)nc1N InChI=1S/C15H18BrN5O/c1-8(2)10-6-18-13(16)5-11(10)22-12-7-19-15(21-14(12)17)20-9-3-4-9/h5-9H,3-4H2,1-2H3,(H3,17,19,20,21) PZEMWICRKUFKQT-UHFFFAOYSA-N 656977 5-((2-bromo-5- isopropylpyridin- 4-yl)oxy)-N2- cyclopropyl- pyrimidine-2,4- diamine::US11919918, Compound C238 P2X purinoceptor 3 Homo sapiens 104 US Patent 10.7270/Q24F1W1X US11919918 Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F BEIJING TIDE PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656977 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656977&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155124092 496176042 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1385063 CC(C)Nc1ncc(Oc2cc(Br)ncc2C(C)C)c(N)n1 InChI=1S/C15H20BrN5O/c1-8(2)10-6-18-13(16)5-11(10)22-12-7-19-15(20-9(3)4)21-14(12)17/h5-9H,1-4H3,(H3,17,19,20,21) OUIMGNLURISCRW-UHFFFAOYSA-N 656978 5-((2-bromo-5- isopropylpyridin- 4-yl)oxy)-N2- isopropyl- pyrimidine- 2,4-diamine::US11919918, Compound C239 P2X purinoceptor 3 Homo sapiens 107 US Patent 10.7270/Q24F1W1X US11919918 Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F BEIJING TIDE PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656978 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656978&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 155124094 496176043 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 1385064 CC(C)c1cnc(NCCO)cc1Oc1cnc(NCCO)nc1N InChI=1S/C16H24N6O3/c1-10(2)11-8-20-14(18-3-5-23)7-12(11)25-13-9-21-16(19-4-6-24)22-15(13)17/h7-10,23-24H,3-6H2,1-2H3,(H,18,20)(H3,17,19,21,22) NXWYDMKWPSKBAO-UHFFFAOYSA-N 656979 2-((4-((4-amino- 2-((2- hydroxyethyl) amino) pyrimidin-5- yl)oxy)-5- isopropyl- pyridin-2- yl)amino)ethanol::US11919918, Compound C242 P2X purinoceptor 3 Homo sapiens 744 US Patent 10.7270/Q24F1W1X US11919918 Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F BEIJING TIDE PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656979 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656979&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 148714728 496176044 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51575506 Fc1ccc(NC(=O)Cn2c3c(cnn3c3nc(ccc3c2=O)C(F)(F)F)C2CC2)nc1 InChI=1S/C20H14F4N6O2/c21-11-3-6-15(25-7-11)28-16(31)9-29-18-13(10-1-2-10)8-26-30(18)17-12(19(29)32)4-5-14(27-17)20(22,23)24/h3-8,10H,1-2,9H2,(H,25,28,31) NYXFNSRGLVKZRV-UHFFFAOYSA-N 50633809 CHEMBL5413520 P2X purinoceptor 3 Homo sapiens 7.0 ChEMBL 10.1021/acsmedchemlett.3c00312 10.7270/Q21R6W0J 37736194 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633809 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633809&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51575507 FC(F)c1ccc2c(n1)n1ncc(C3CC3)c1n(CC(=O)Nc1ccc(F)cn1)c2=O InChI=1S/C20H15F3N6O2/c21-11-3-6-15(24-7-11)27-16(30)9-28-19-13(10-1-2-10)8-25-29(19)18-12(20(28)31)4-5-14(26-18)17(22)23/h3-8,10,17H,1-2,9H2,(H,24,27,30) VEDYMWGCSRKJQB-UHFFFAOYSA-N 50633810 CHEMBL5410018 P2X purinoceptor 3 Homo sapiens 4.0 ChEMBL 10.1021/acsmedchemlett.3c00312 10.7270/Q21R6W0J 37736194 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633810 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633810&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51575508 CC(C)c1ccc2c(n1)n1ncc(C3CC3)c1n(CC(=O)Nc1ccc(F)cn1)c2=O InChI=1S/C22H21FN6O2/c1-12(2)17-7-6-15-20(26-17)29-21(16(10-25-29)13-3-4-13)28(22(15)31)11-19(30)27-18-8-5-14(23)9-24-18/h5-10,12-13H,3-4,11H2,1-2H3,(H,24,27,30) HNJFPTYOHFDLOH-UHFFFAOYSA-N 50633811 CHEMBL5422168 P2X purinoceptor 3 Homo sapiens 6.0 ChEMBL 10.1021/acsmedchemlett.3c00312 10.7270/Q21R6W0J 37736194 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633811 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633811&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51575509 Fc1ccc(NC(=O)Cn2c3c(cnn3c3nc(ccc3c2=O)C2CC2)C2CC2)nc1 InChI=1S/C22H19FN6O2/c23-14-5-8-18(24-9-14)27-19(30)11-28-21-16(12-1-2-12)10-25-29(21)20-15(22(28)31)6-7-17(26-20)13-3-4-13/h5-10,12-13H,1-4,11H2,(H,24,27,30) JBXNYPOEZQWTJX-UHFFFAOYSA-N 50633812 CHEMBL5425676 P2X purinoceptor 3 Homo sapiens 7.0 ChEMBL 10.1021/acsmedchemlett.3c00312 10.7270/Q21R6W0J 37736194 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633812 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633812&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51575510 FC(F)c1cnn2c1n(CC(=O)Nc1ccc(F)cn1)c(=O)c1ccc(nc21)C(F)(F)F InChI=1S/C18H10F6N6O2/c19-8-1-4-12(25-5-8)28-13(31)7-29-16-10(14(20)21)6-26-30(16)15-9(17(29)32)2-3-11(27-15)18(22,23)24/h1-6,14H,7H2,(H,25,28,31) MTGISWZIPPEVQE-UHFFFAOYSA-N 50633813 CHEMBL5406794 P2X purinoceptor 3 Homo sapiens 7.0 ChEMBL 10.1021/acsmedchemlett.3c00312 10.7270/Q21R6W0J 37736194 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633813 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633813&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6 51575511 Fc1ccc(NC(=O)Cn2c3c(cnn3c3nc(sc3c2=O)C2CC2)C2CC2)nc1 InChI=1S/C20H17FN6O2S/c21-12-5-6-14(22-7-12)24-15(28)9-26-19-13(10-1-2-10)8-23-27(19)17-16(20(26)29)30-18(25-17)11-3-4-11/h5-8,10-11H,1-4,9H2,(H,22,24,28) OZDHDOBJQRWKAI-UHFFFAOYSA-N 50633814 CHEMBL5409070 P2X purinoceptor 3 Homo sapiens 7.0 ChEMBL 10.1021/acsmedchemlett.3c00312 10.7270/Q21R6W0J 37736194 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633814 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5767&target=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633814&enzyme=P2X+purinoceptor+3&column=ki&startPg=0&Increment=50&submit=Search 1 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH P2X purinoceptor 3 P2RX3_HUMAN P56373 Q6DK37 Q9UQB6